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OTAR3088
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BioData-CellLine_annotated

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PMC9250505
A positive correlation between pBADS99 in EOC with higher disease stage and poorer survival is observed.
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PMC11391695
ns, non-significant, *p < 0.05 Synthesis and identification of pcDNA/PEI/NPs@M nanocomposites.
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PMC10938336
These properties collectively offer valuable insights into the druglikeness potential of these monocarbonyl curcuminoids-related analogues, laying the foundation for further investigations into their therapeutic properties and potential as drug candidates.
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PMC11419566
As ER stress status worsens and UPR are unable to treat it, the accumulation of ATF6, IRE1, and PERK would cause eIF2α phosphorylated.
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PMC11684297
In the case of PC12 cells, which can be taken as a model cell for any neurological studies, we could observe no morphology change after treatment with ZnO-NFs up to a dose of 200 µg/ml (Fig. 3a).
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PMC11064533
As a result of this comparison, 325 proteins were expressed at a higher level in bacteria in the supernatant as compared to 422 proteins having higher expression in the adhering state of bacteria, as shown in the volcano plot (Fig. S6).
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PMC2193049
The purified material was then subjected to matrix assisted laser desorption ionization-time of flight (MALDI-TOF) and analytical HPLC analysis.
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PMC11659734
This project significantly contributed to advancing genotoxicity assessment methods for chemicals used as BPA alternatives in combination with NAMs, laying the groundwork for potential OECD Test Guideline development and regulatory readiness.
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PMC11759543
CI < 0.90 indicates synergism, CI = 0.90–1.10 indicates addition, and CI > 1.10 indicates antagonism.
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PMC9429973
Test compound and vehicle control were administered subcutaneously every two days.
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PMC10813895
ELF5 functions as a tumor suppressor in bladder , kidney , ovary , and prostate cancers.
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PMC11713609
Magnification, 20×; scale bar, 100 µm. (
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PMC9429973
Regarding the treatment, 9 patients (45% of cases) received the Cybor-D protocol, 6 patients were treated with the BorTD protocol, 4 patients received the M-Dex regimen, and 1 patient died before starting treatment.
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PMC6684588
ACE-083 utilizes properties of FST291, an engineered, truncated variant of FST315 in which the intrinsic HBS is fully functional.
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PMC9000591
Callerya speciosa is widely distributed in tropical and subtropical countries and is traditionally used for preventing numerous disorders.
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PMC10547921
The first synthetic and evaluated cryptophycin analog, cryptophycin-1 (35), had an IC50 of 4.58 pmol/L for KB cells and 7.63 pmol/L for LoVo cells(Fig.
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PMC11759543
After 24 h treatment, cells were applied MTT assay for cell viability analysis.
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PMC11806818
The structure of aptamers is relatively flexible and can be easily modified chemically.
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PMC10605143
The sequence recognized by the EcoRI restriction enzyme was introduced into the primers.
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PMC11055323
To test it, we mutated all the acidic amino acids which has been reported to recognize H2AK119ub , by alanine in the C terminus of SSX1.
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PMC10723784
Cells were then left in the incubator for a further 24 or 48 h. Then the media was replaced with fresh media containing no drug and the cells were left in the incubator.
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PMC11799620
This can lead to economic and environmental problems.
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PMC9429973
One pt experienced Grade 4 clinical tumor lysis syndrome with resultant acute kidney injury during venetoclax dose escalation, which resolved with supportive measures.
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PMC11026382
To initiate the reaction, the protein-NADPH solution was mixed with DHF in a quartz cuvette (sampling DHF over a range of concentrations, tuned to the Km of the mutant).
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PMC11365983
In immortalised E16.5 chondrocytes, that express high levels of Foxc1, Foxc1 shRNA inhibition decreased basal level of Gli1 mRNA (n = 3). (
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PMC11741577
Briefly, RNA was denatured at 70°C for 5 minutes, mixed with 4 μl of the Reverse Transcription Master Premix, and incubated at 42°C for 1 h. It was further incubated at 94°C for 5 minutes.
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PMC9964635
White, amorphous solid.
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PMC9429973
All patients provided written informed consent to participate the study.
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PMC11805741
The molecular docking results for the interaction between the BCL-2 protein and the ligand obatoclax reveal a moderately strong binding affinity.
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PMC4277423
Thus, taken together we concluded that CCR5 gene-disrupted cells are resistant to R5 viruses and exhibit a selective survival advantage during R5 HIV-1 infection.
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PMC11543853
c, d Surface representations of single-particle cryo-EM reconstructions of rhinovirus 2 virion (c) and empty particle (d) calculated from projection images of infected cos-7 cells.
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PMC11757230
These data suggest that cADSCs inhibit, rather than promote, the growth of canine lymphoma cells in immunocompromised mice.
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PMC11638255
To stimulate immune activation in Th-MYCN model, we primed the tumor microenvironment by administering the copper chelating agent TEPA daily for 1 week, followed by the addition of twice weekly doses of anti-GD2 antibody (Fig. 1a).
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PMC10933092
Ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) assays quantify mA levels in total RNA from sh-NC and sh-TRMT61A 5637 cells (n = 4).
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PMC11746948
MBOAT1/2 inhibit ferroptosis by increasing the cellular content of monounsaturated fatty acids (PE-MUFA) and correspondingly decreasing the cellular content of polyunsaturated fatty acids (PE-PUFA), which are the preferred substrates for phospholipid peroxidation, thereby remodeling the cellular phospholipid profile an...
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PMC10654497
Ferroptosis-related medications are gradually being used in clinics; therefore, determining the function of ferroptosis regulators in tumor therapy is becoming increasingly crucial.
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PMC11265931
Next, 100 μL of TMB One-Step Substrate Reagent was transferred to each well and incubated for 30 min at room temperature with gentle shaking in the dark.
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PMC9429973
At 6 months post allo-HSCT, 5% and 36% of the disease-free patients in the PT-Cy group were living with GVHD and IST, respectively.
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PMC11422150
The mice were sacrificed on Day 6 after the SCI inductions.
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PMC11532793
Throughout the years, differential expression analysis of RNA-seq data has often been conducted with a gene-centric view (3).
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PMC8633974
Treatments notably depend on host FcR-mediated cellular killing or antigen presentation in MHC-I and, as such, rely on host immunity for viral clearance.
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PMC9681981
The culture medium was replaced every day, and the cells were examined under an inverted microscope (Olympus, Japan) until reaching 100% confluency.
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PMC11332076
Fig. 2 Immunocytochemical analysis of ERK and AKT activation by F-iIR and F-iIGF1R in the absence of insulin.
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PMC11541241
Potential homologues of AMPK are conserved throughout the species examined.
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PMC11345828
B. Heat map of cell growth inhibition and C. synergy between the two treatments based on BLISS Gap score.
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PMC11337594
A representative density plot of Annexin V-FITC/PI staining is shown in Fig. 2G.
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PMC9503541
After the analysis, the top 50 metabolites with the lowest p and p[corr] values were obtained.
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PMC11621493
Overexpression of the enzyme in COS7 cells increases the abundance of TAG, particularly favoring the accumulation of PUFA-containing species.
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PMC9429973
As a result, a leucine-rich motif (L-xxx-V-xx-V-x-L) is formed, which is a signal sequence for protein export from the nucleus to the cytoplasm.
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PMC10758402
01-2222-42), which are single-stained beads were used for compensation.
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PMC8922418
However, once the targeting RNA was detected by the CRISPR/Cas13a gRNA, the reporter RNA could be broken to release fluorescence that a detector can measure (Kellner et al., 2019).
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PMC9429973
M. Federico, Y. Stepanishyna, T. Skrypets, C. S. Chiattone, M. H. Prince, A. Pavlovsky, A. Lymboussakis, M. Manni, M. Civallero, C. A. de Souza, E. A. Hawkes, L. Fiad, R. Nair, I. Kriachok, F. Hitz, O. Kostina, C. Tomuleasa, A. Guarini, S. Luminari Surgical, Medical and Dental Department of Morphological Sciences relat...
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PMC11300639
d 786-O cells were transfected with indicated plasmids for 48 h. Cells were harvested for immunofluorescence staining by using the RNF26 or TSC1 antibodies.
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PMC9429973
Efficacy has also been shown in the relapsed/refractory (R/R) setting in more limited data sets (Báez-Gutiérrez et al., 2021; Pollyea et al., 2020, Stahl et al., 2020; DiNardo et al., 2019).
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PMC11706491
However, there was a caveat using a constitutively Sty1-deficient strain, given the pleiotropic phenotypes of this strain, ranging from heightened sensitivity to various extracellular and intracellular stresses to a shortened lifespan .
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PMC7351993
Fast wavelength switching of the Stokes pulses is realized by the four-color band-pass filter (Supplementary Figs. 3b, 1b).
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PMC11772585
Moreover, heightened ATF4 expression is crucial for tumor cell growth and acts as a defense mechanism against tumor cell death .
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PMC11696659
B, interquartile of the telomere lengths of a sample (p < 0.0001).
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PMC9429973
The most common B-NHL associated with localised amyloidosis was ENMZL MALT-type (10 cases, 1 case with hybrid amyloidosis AL kappa/AH IgG1), in 4 specimens LPL was detected.
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PMC11519567
two-sided, unpaired t test, **P < 0.01.
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PMC5386478
Parallel induction of TGM2-v1 at 72 h in spheroids was assessed by real-time PCR (Figure 3e).
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PMC11486946
Scale bar, 3 μm.
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PMC10926885
Procell Life Science and Technology sold the T24 and 5637 cell lines for human bladder urothelial cancer.
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PMC11700247
To validate the relevance of the STING pathway in the additive effects of RT with CART-19 cells in vivo, we blocked STING using H-151, a well characterized STING antagonist.
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PMC9429973
instead of s.c.
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PMC8735881
First, a panel of newly generated HIV-1 neutralizing antibodies was comprehensively characterized as membrane-bound scFv inhibitors and found that GPI-anchored 10E8 was the most effective in the inhibitions of cell-free HIV-1 infection, cell-associated HIV-1 transmission, and viral Env-mediated cell–cell fusion.
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PMC9545474
Complexes were dissolved in either DMSO or PBS to provide stock solutions which were further diluted with media to provide a range of final concentrations.
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PMC11750712
Clinical data are captured in the clinical database via the Encapsia electronic data capture system v1.0.
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PMC11144382
NFIX is reported to suppress BBX transcription but activate GFAP expression, in neural progenitor cells and astrocytes, respectively.
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PMC11574271
G The tumor growth was assessed periodically and represented in a line chart.
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PMC11406030
Western blot membranes were hybridized with LMTK3 biotin-labeled peptide #1 and LMTK3 antibody, followed by detection with the avidin-biotin complex.
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PMC9429973
A broad search string was set up with four search blocks: the first included a validated search filter for finding prognostic and diagnostic predictions studies.
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PMC11706776
In B, C, bars indicate means ± SD of relative and normalized EWS::FLI1 or KCNN1 mRNA expression determined by RT-qPCR.
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PMC9429973
Efficacy endpoints (SC/SC and IV/SC) remained stable over time through 1 year of SC ravulizumab treatment.
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PMC11705547
IFN-γ: interferon-γ, TNF-α: tumor necrosis factor-α, TAM: tumor-associated macrophage, APC: antigen-presenting cell, CTL: cytotoxic T-lymphocyte, MDSC: myeloid-derived suppressor cell, DC: dendritic cell, CAF: cancer-associated fibroblasts, ROS: reactive oxygen species.
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PMC11306019
Polyphenols, a large family of natural compounds with multiple phenol groups, are abundant in fruits, vegetables, herbs, spices, tea, dark chocolate, and wine.
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PMC11583690
Briefly, 1 mg of the nanomaterial was added to 1 mL of DTX (1 mg/mL) in the respective solvents.
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PMC11306019
Therefore, it is conceivable that dietary polyphenols at their physiological concentration might counteract BTZ at its average blood concentration.
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PMC11126803
D, Human Cancer Database results show that the expression of LncRNA-SERB in primary RCC tumors is higher than that in normal tissues.
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PMC11746948
To confirm APT2’s regulatory impact on GPX4, we reintroduced a shRNA-resistant form of APT2 into APT2-knockdown cells.
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PMC11637276
In addition, the IC50 of the compounds for MAPK11 is higher than MAPK14 ; therefore, a higher concentration might be required to fully inhibit MAPK11, which appears to be the major regulator of ECM uptake.
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PMC10747160
From our observations, although the Raji cells did not appear to adhere to wells, they did not move from the bottom of the wells when we removed media.
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PMC9878562
The physiological importance of the CXCL12/ACKR3/CXCR4 axis is underlined by the fact that absence of either component causes perinatal death in mice severely disrupting central nervous system and heart development (8–11).
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PMC3681794
A, 791T, HOS and U2OS osteosarcoma cells were incubated in normoxia (N) or hypoxia (H) for 48 hours before lysates were analysed for PTEN, Akt and Akt phosphorylated at serine 473 by western blotting.
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PMC9220170
which is a transmembrane domain .
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PMC9429973
Their feedback confirmed the pedagogic relevance of these podcasts for undergraduate students across years 1 to 5 as part of curricular learning.
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PMC10747160
Since there are 22 putative glycan sites on each monomer of the SARS-CoV-2 spike protein, it is highly likely that even if Griffithsin blocks DC-SIGN from binding a particular glycan, DC-SIGN can easily shift from binding one glycan to binding to another .
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PMC9429973
No QTcF prolongations >480 msec were noted.
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PMC9429973
However, resistance to TKIs has emerged due to different factors.
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PMC11659921
Through multivariate Cox regression analysis and Friends analysis, TNFSF11 emerged as the most promising prognostic gene.
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PMC11768281
A systematic search strategy was developed, combining specific keywords with Boolean operators, and applied across four online databases: PubMed, Scopus, Cochrane Library, and Google Scholar.
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PMC9429973
The most frequent AE during cycle 1 was thrombocytopenia (all grade 30%, Gr 3/4 20%) and blurred vision (all grade 20%, Gr 3/4 0%) One patient experienced Gr 4 neutropenia.
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PMC11742431
The primary antibodies used in western blot were anti‐EGPF (mouse/IgG1; 1:2000; Leading Biology), anti‐GAPDH (mouse/IgG2b (Immunoglobulin G2b); 1:50,000; Proteintech), anti‐PD‐L1 (Rabbit/IgG; 1:200; ABclonal), anti‐Furin (rabbit/IgG; 1:1,000; ABclonal), anti‐Survivin (mouse/IgG1; 1:3,000; Proteintech), and the secondar...
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PMC9429973
Pts in cohort 2 must have R/R AML after initial IC.
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PMC11746942
A Representative macroscopic images and histological staining (H&E, Masson’s trichrome, and PAS) of mouse dorsal skin treated with TY (3 mg/kg/day) or the solvent control prior to daily topical application of IMQ (62.5 mg/day).
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PMC6835428
In xenograft mouse models, cells of different genetic backgrounds can be injected into immunocompromised animals via three different routes: subcutaneous (SC), intraperitoneally (IP), or intrabursally (IB, i.e., into the bursa that surrounds the mouse ovary) .
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PMC11794588
This action in HeLa cells is linked to β-amyrin’s anti-inflammatory and apoptosis-inducing properties.
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PMC11656657
The antitumor activity was confirmed by robust cytokine production and real-time tumor cell lysis.
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PMC9429973
The median duration of treatment was 15.5 months.
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PMC11617590
In Mia PaCa‐2 cells with abnormal KRas, the inhibition of GSK‐3β was found to induce the activation of caspase‐3 and PARP fragmentation .
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