PMCID string | Sentences string | ner list |
|---|---|---|
PMC11350568 | Comparison of the binding ability of aptamers against MV-4–11 cells. | [
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PMC11040965 | P < .05, Wilcoxon signed-rank test We used the same assay to assess whether CD28 engagement influences levels of miR29b and its target DNMT3B in U266 and RPMI 8226 myeloma cells (Fig. 1C-E). | [
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PMC8708099 | The symptoms of the disease can be reduced by using appropriate pharmacological agents, but IBD is not fully curable . | [
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PMC9847912 | Titers produced by transfecting the M3 clone into 293T/17 cells (as measured by plating 293T/17 supernatants onto MAGIC-5A cells) were 25% of those produced by the parental HIV-2ROD9 plasmid, indicating a substantial fitness cost. | [
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PMC11577421 | in handling more heterogeneous size distributions. | [
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PMC11574271 | In summary, the current research has revealed that decreased expression of has-mir-659-3p plays a significant role in the upregulation of RON in bladder cancer. | [
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PMC11536589 | Then, we utilized the R package “monocle” to compute and visualize the pseudo-time trajectories of all KPC cells. | [
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PMC5916734 | The copy numbers of the auxiliary genes in all the generated clonal cell lines were significantly lower than that of the FIX gene, because cell clones were not selected in accordance with the maximum activity of the vkorc1 gene. | [
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PMC11607638 | The animal protocol used in this work to isolate pancreatic acini from male rats was approved by The Animal Use and Ethics Committee, College for Life Sciences, Beijing Normal University (No. CLS‐EAW‐2017‐015). | [
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PMC11607638 | All experimental data were processed and analyzed with GraphPad Prism (RRID:SCR‐002798) 8.4.0. | [
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PMC9268620 | The same observations were also found in the treatments with 1 and 3 μg/mL of nordamnacanthal, showing that the compound at low concentrations did not affect the cells. | [
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PMC11747949 | Gathered supernatant was centrifuged again 1000 × g for 5 min, and prepared for ELISA analysis. | [
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PMC9429973 | N. Jain, P. Thompson, J. Burger, A. Ferrajoli, K. Takahashi, Z. Estrov, G. Borthakur, P. Bose, T. Kadia, N. Pemmaraju, K. Sasaki, M. Konopleva, E. Jabbour, N. Garg, X. Wang, R. Kanagal-Shamanna, K. Patel, W. Wang, S. Wang, J. Jorgensen, W. Lopez, A. Ayala, W. Plunkett, V. Gandhi, H. Kantarjian, S. O’Brien, M. Keating, ... | [
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PMC11629143 | ChIP‐qPCR and RT‐qPCR primer sequences. | [
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PMC11487720 | In contrast, when WWOX-deficient or -dysfunctional (WWOXd) cells are exposed to UV and/or cold shock, the cells undergo nuclear pop-out explosion death (POD). | [
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PMC8068766 | Therefore, it is essential to determine the stress response gene expression profiles of these cells due to their involvement in hepatocarcinogenesis (Di Maso et al., 2015). | [
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PMC10094712 | hSELENOM penetrates into cells, most likely via actin-dependent endocytosis as shown in this work (Figure 8), and interacts with reduced glutathione due to the presence of the CXCS active center (where C is cysteine and X is any amino acid). | [
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PMC11684269 | PD-1 facilitates the metabolic rewiring of activated T cells from glycolysis to FAO by upregulating CPT1A, thus exerting the immunosuppressive capacity (54). | [
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PMC11116779 | Particles sized less than 10 μm enter the lungs and can reach the alveolar cells, which accumulate these air pollutants over a lifetime (19). | [
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PMC9813422 | The HPV E2 protein binds viral episomes to mitotic host chromosomes during cell division for partitioning and maintenance. | [
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PMC9429973 | Our nomogram may help clinicians in clinical decision making. | [
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PMC11740399 | Lipids are transported from the liver to peripheral tissues or back to the liver through lipoproteins . | [
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PMC9926039 | P < 0.05 (P < 0.05) was considered statistically significant. | [
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PMC9119314 | However, when compared with its cytotoxicity to Hep G2 cells, 6 exhibits better selective toxicity against gametocytes than 2 (SI = 13 and 2.5, respectively, Table 1). | [
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PMC6379402 | Note that none of our data networks are well fitted by any of the tested random models (all MWU p-values were lower than 5%, as the two distributions do not overlap, e.g., Fig. 2d in the main document). | [
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PMC9429973 | Six (7%) pts, 3 MPLS505N, 2 JAK2V617F, and one wild type, without thrombophilic abnormalities, experienced a thrombotic event. | [
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PMC11640555 | Western blot analysis was performed to investigate CK2 levels in hCMEC/D3 cell lysates after treatment with CX-4945 at concentrations of 5 μM, 10 μM, and 15 μM. The results demonstrated that CX-4945 significantly reduced the p-CK2 levels at higher concentrations of 10 μM and 15 μM compared to untreated hCMEC/D3 cells (... | [
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PMC11395280 | The cells were induced to migrate for 3 h at 37 °C in a 5% CO2 humidified incubator. | [
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PMC10237474 | Therefore, our study strongly suggests that the growth advantages of Expi293F GnTI coupled with the robustness and simplicity of the PB transposon system makes Expi293F GnTI stable pools superior for producing high-quality soluble glycosylated proteins. | [
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PMC11774112 | The iScript cDNA synthesis kit and SYBR master mix were purchased from Bio-Rad (Hercules, CA, USA). | [
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PMC9386809 | However, further experimentation work is needed to establish the precise mechanism responsible for the anticancer activity of the synthesized complex. | [
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PMC11422497 | RT-qPCR, reverse transcription- quantitative PCR. | [
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PMC9429973 | All pts provided informed consent. | [
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PMC11593713 | In the presented study OSI values were significantly increased in A549 cells after viral infections in all studied groups when compared to the control but not in MCR-5 cell lines. | [
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PMC11411004 | ns, the difference was not significant. ** | [
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PMC5941560 | This fundamental TCR signaling defect in Jurkat led many researchers to question its validity as a model system for T-cell studies . | [
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PMC11394227 | After that, the cells were analyzed by flow cytometry (Beckman Coulter, Brea, CA, USA). | [
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PMC11733919 | Samples were prepared at a concentration of 0.02 mg of Fe/mL in Milli-Q water and sonicated 10 s before measurement. | [
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PMC11200978 | In the case of LC, while numerous studies have demonstrated that CA can be used to effectively target NSCLC and support lethality in the −20 °C to −35 °C range , the definition of the MLT for LC remains unclear. | [
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PMC5035325 | A p value, 0.05 was considered statistically significant. | [
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PMC10495912 | Also, the Kollman bar was used to attribute the bar to the protein. | [
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PMC4270159 | Each cohort will consist of cells treated with media alone, with vehicle alone, with the primary kinase inhibitor, with primary kinase inhibitor and the rescuing ligand and with the primary kinase inhibitor, the rescuing ligand and the secondary kinase inhibitor. | [
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PMC11021472 | Mean ± SD of two independent experiments is shown. ( | [
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PMC11746948 | To elucidate whether 2-BP regulates ferroptosis at the transcriptional level, we performed RNA sequencing analysis on A375 cells with 2-BP treatment or not. | [
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PMC11700340 | The study has found that linagliptin successfully reduces the growth of cervical cancer cells with a time-dependent cytotoxic pattern. | [
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PMC10882807 | In this study, hsa_circ_0005397 was found to be significantly upregulated in HCC, and the good diagnostic sensitivity and specificity shown a potential diagnostic capability. | [
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PMC11762280 | Similar results were observed in histological features; with increasing irradiation dose, the epidermal gradually thickened, the degree of epidermal necrosis and inflammatory cell infiltration gradually intensified, and the TUNEL positive staining in epidermis gradually increased (Fig. 1D). | [
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PMC11604768 | Each TRE unit was examined for compatibility with our restriction enzyme strategy and modified as necessary to remove unwanted recognition sites. | [
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PMC9429973 | The estimated median OS by treatment group (Figure 1C) was 8.4 mo with intensive CIT + ven, 10.6 mo with BTKi + ven +/- CD20 antibody and not reached with R-CHOP + ven. | [
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PMC10291556 | Extensive studies on unconventional platinum(II) complexes of general formula [Pt(PL)(AL)], where PL is a polyaromatic ligand, and AL is an ancillary ligand, have yielded some promising results. | [
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PMC11534377 | Pathogen-free eight-week-old female immunodeficient athymic nude mice (n=10) purchased from (Charles River, Hungary) were included in the study. | [
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PMC11806106 | The opioid receptor family represents important drug targets, particularly in the management of severe pain which is mainly treated through the stimulation of µ opioid receptors. | [
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PMC11525028 | Scale bars: 50 μm (left), 25 μm (right) (n = 5 per group). | [
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PMC11683240 | Effect of the serpin proteins α1AT and antithrombin on intoxication of CHO-K1 cells with PT.A–C, PT (10 ng/ml) and α1AT (100 μM), antithrombin (AT) (100 μM), and fondaparinux (Fon) (1 g/l) or the respective amount of solvent (H2O) were added directly to CHO-K1 cells in FCS-free medium and incubated for 4 h at 37 °C. | [
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PMC9621239 | In fact, patients with genotype C had a relatively poorer response to IFN than those with genotype B. Moreover, previous studies show that patients with genotype C harboured more rtA181T/V mutations than those with genotype B after antiviral treatment, and rtA181T/V was reported to reduce HBV susceptibility to LMV. | [
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PMC9429973 | We found an increased risk of CHF for AML-LTS who have had AML relapse (OR, 3.16; 95% CI: 1.46 – 6.83; P=0.004) and, in trend, for patients with sAML or tAML (OR 2.19; 95%CI: 0.92 – 5.22, P=0.076). | [
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PMC9429973 | The median OS and PFS time were not reached for the total population. | [
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PMC9878278 | Therefore, we next assessed the gene expression of two key BMPs (BMP2 and BMP6) at different time points after infection. | [
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PMC11711063 | The upregulation of laminins, fibrillins, and collagen IV indicated a change toward matrix deposition and increased density. | [
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PMC10820104 | Consequently, there is an immense need to find new drugs or drug leads for curing this disease . | [
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PMC11593713 | Based on the available literature, it was determined that each of the tested viruses replicated efficiently in the chosen cell lines . | [
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PMC11770199 | The sizes of isolated tumor mass in the mMSCs-p14 group were significantly smaller compared to the saline group and the mMSCs-GFP group (Fig. 4G and H). | [
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PMC7553912 | The apparent molecular weights are indicated on the right. ( | [
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PMC5925824 | Human complement was added into the assay plates and incubated for 1 h at 37 °C. | [
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PMC11541409 | 42(3_suppl): p. 748-748.This reference is of outstanding importance because it reports that ripretinib has the similar effcicay with sunitinib as a second line therapy drug for GIST patients after imatinib failure. | [
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PMC10538569 | To obtain confocal images of GPI-GFP transfer to iDCs, 5×10 iDCs were resuspended in 300 µl of complete DMEM and seeded in 8 well chamber slides (IBIDI) 24 hours before imaging. | [
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PMC10142392 | Click" reactions such as alkyne-azide and esterification have been particularly popular in this approach. | [
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PMC11730000 | Specifically, it was noted that a concentration of 200 µM EGCG increased oxidative DNA damage in human lymphocyte DNA induced by H2O2. | [
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PMC11285179 | Our work might provide a prospective molecular marker for guiding the clinical arrangement of combination therapy between anti-angiogenesis treatment and other therapies. | [
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PMC11772585 | The reagents were added sequentially according to the manufacturer’s instructions, and a microplate reader was used to measure the glucose content in the culture supernatant. | [
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PMC9429973 | Heterochromatin protein-1 alpha (HP1-α) IF (Immunofluorescence) staining was used to show the distribution of heterochromatin. | [
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PMC11155445 | Sashankh et al. synthesized thirteen novel acyl thiourea derivatives via reaction of aliphatic/aromatic isothiocyanates and 4-(4-phenylpiperazin-1-yl)aniline in dry acetone. | [
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PMC10387886 | Our results indicating the induction of EMT in SKOV3 cells upon TGFβ1 addition are consistent with the study carried out by Hou et al. . | [
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PMC11464982 | This was done for all individuals across all surveys, resulting in distributions of individual average exposure. | [
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PMC10965680 | Many of the genes found through signal analysis, such as CHRM2, SDC1, ITCH, and FGF12, are related to hair follicle growth. | [
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PMC9444294 | After washing off the unbound primary antibody the next day, cells were incubated with PLA probes at 37°C for 1 h. Subsequently, they were incubated with ligation reagent for 1 h, followed by the amplification reagent for 100 min. | [
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PMC7685376 | Then, liquid chromatography and tandem mass spectrometry (LC-MS/MS) analysis was performed according to the manufacturer’s protocol. | [
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PMC9503541 | Molecular networking works by either matching experimental spectra against reference spectra (targeted metabolomics) or by aligning experimental spectra against one another and connecting related molecules based on spectral similarity (untargeted metabolomics) to find candidate metabolites directly from fractionated bi... | [
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PMC11489351 | Gene names and GO terms were identified using the Ensembl version of BioMart (100). | [
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PMC6835428 | Only a reduced amount of siRNA can be internalized via endocytosis. | [
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PMC9429973 | Aims: 1. | [
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PMC11768927 | Conversely, silencing HIF-1α expression using RNA interference significantly improved tumor susceptibility to VSV-mediated oncolysis. | [
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PMC11225860 | During G1, red fluorescent cdt1-mKO is expressed which transitions to green as Geminin-clover is expressed during S-G2. | [
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PMC9874064 | The green fluorescence comes from the cytoskeleton stained with Alexa-488. | [
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PMC11248911 | Prior to production simulation, energy minimization of the system was carried out by using steepest descent algorithm (5000 steps). | [
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PMC11155445 | The docking study also supported the above results and it was found that the compounds (151c and 151g) showed strong binding of −32.18 and −30.09 kJ mol, respectively (Fig. 78). | [
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PMC11767817 | The most potent effect was observed for compound 2a at concentrations of 8 µM and 10 µM after 20 h of incubation. | [
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PMC9429973 | The role of common functional innate immunology genes in the incidence in patients with AML remains unclear as previous studies provide conflict results. | [
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PMC11001582 | Medium was exchanged daily for a total of 7 d to facilitate the removal of iPSNs that failed to recover postnucleofection. | [
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PMC6684588 | Stop solution was used to halt the colorimetric reaction, which was read at a wavelength of 450 nm using a VersaMax microplate reader (Molecular Devices, San Jose, CA). | [
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PMC9065483 | This previously unappreciated mechanistic insight adds to our understanding of key signaling pathways that contribute to successful OV therapy regimens and will facilitate pre-clinical and clinical development of vanadium compounds as enhancers of OV therapy. | [
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PMC11476837 | Additionally, the expression of NRF2-regulated antioxidant and detoxification genes including SOD2, HMOX2, and GSS was maintained upon ML-385 treatment. | [
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"tokens": [
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... |
PMC11092418 | In addition, whereas treatment with all agents resulted in upregulation of the cells in the S phase of cell cycle in A172, the same treatments reduced the percentage of cells in the S phase in U118MG cells, highlighting the heterogenous nature of brain cancer cells. | [
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"O",
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... |
PMC11359735 | We performed metabolic labeling experiments to assess the incorporation of radiolabeled GPI precursors into CSP. | [
{
"tags": [
"O",
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"O",
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PMC11706776 | RNA-seq was performed for ES and osteosarcoma cells and gene-level quantification was realized as previously described . | [
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PMC11711935 | Furthermore, it can suppress Peroxisome Activator Receptor (PAR)‐2 expression in keratinocytes thus reducing melanin transfer. | [
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PMC11310713 | At 12 weeks after HRT, uterine tissues were harvested from rats, and gross images were obtained. | [
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PMC11655498 | XBP-1 can activate Rp independently, whereas the activation of Zp by XBP-1 requires cooperation with PKD (Bhende et al., 2007). | [
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"tokens": [
... |
PMC8557138 | Emerging evidences have surfaced the role of the nervous system in regulating tumor angiogenesis (Jiang et al. 2020). | [
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PMC11564322 | In the group co-treated with the VGVAPG peptide and the c-SRC inhibitor I, a 43.86% increase in the PPARγ protein expression was observed, compared to the control (Fig. 8E). | [
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... |
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