OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11185260	The IC50 values, the drug concentration resulting in 50% cell death, were interpolated from the graph of DNA concentration versus the fraction of surviving cells using SigmaPlot 11.2 (Systat Software, San Jose, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	Genome-wide, 33% of all H1 TAD boundaries have a matching boundary in GM12878 in the same or an adjacent 40-kb bin (K562: 31%, null model: 18%; Kolmogorov–Smirnov test: D=0.26, p≈0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5363531	Indeed, in all five clones we observed a significant reduction (> 75–80%) of luciferase levels compared to untreated condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed"...
PMC11623887	These findings underscore the inhibitory role of FAM122A in regulating erythroid differentiation and suggest its potential as a therapeutic target for conditions associated with GATA1 dysfunction, or as a crucial regulator for expanding red blood cells in laboratory settings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11760643	p < 0.05; p < 0.01; no significant difference (ns).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ";", "p", "<", "0.01", ";", "no", "...
PMC11765879	An Aliquot of 10 mg of the extract powder was dissolved in 250 µL DMSO, providing a solution with a stock concentration of 40 mg/mL that was stored at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	H Concentration–response curve for dynorphine A at the KOR BRET (blue) and KOR FRET (magenta) receptor conformation sensor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11659734	Advanced 3D mini‐tissue and mini‐organ models provide a more accurate simulation of cellular organisation and function than traditional two‐dimensional cell cultures grown in monolayers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11720107	The analysis revealed that the Harnaś cultivar is rich in apigenin, catechin, ferulic acid, isoharmentin, sinapic acid, and vanillic acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9917080	Incubation of selenium nanoparticles with A-172 cells for 24 h, such as sorafenib, led to the suppression of the kinase expression, and this effect increased after 48 h. The SeSo nanocomplex had effects similar to the use of sorafenib, i.e., after 24 h of treatment, the expression of kinase genes increased; however, af...	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	Ovarian cancer (OV) is a highly lethal disease that impacts the female reproductive system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ovarian", "cancer", "(", "OV", ")", "is", "a", ...
PMC11680562	Some of the symptoms are aberrant vaginal bleeding, pelvic discomfort, and weight loss.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "of", "the", "symptoms", "are", "aberrant", "vaginal...
PMC11790599	Despite recent advances in prevention and treatment, breast cancer remains a formidable adversary, causing 670,000 deaths and 2.3 million new cases globally in 2022 (Bray et al., 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10955424	Exposure to malignant ascites resulted in the elevation of cell counts in A2780cisR cells treated with RJY13 compound, while ascites derived from cirrhosis patients did not result in an increase in cell count (Fig. 1G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267036	Here, dihydromyricetin (DHM) dose-dependently restrained viability, apoptosis, migration, and invasion, and facilitated apoptosis of U266 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ ...
PMC6461034	ALK is a high‐ranking kinase with roughly equal evidence from both analysis arms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ALK", "is", "a", "high‐ranking", "kinase", "with", "roughly", "equal", ...
PMC9429973	Summary/Conclusion: In our experience, single agent AZA alone was effective and well tolerated in heavily pretreated patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "In", "...
PMC9429973	Early results demonstrate promising efficacy with combination therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Early", "results", "demonstrate", "promising", "efficacy", "with", "combination", "therapy", "." ] } ]
PMC11055323	h Tumor growth curve of SW982 cell overexpressing mCherry, SS18-SSX and N12 fused SS18-SSX xenografts established in NCG mice for 21 days.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], ...
PMC9429973	Chromothriptic events involve multiple loci in CLL patients; 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chromothriptic", "events", "involve", "multiple", "loci", "in", "CLL", "patients", ";", "2", ...
PMC10213199	The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis, whereas shorter gene products (isoforms 2 and 3) may promote apoptosis and cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	A Flip-out cassette expressing Dachs:GFP with an intervening transcriptional stop cassette flanked by FRT sites was introduced into Ds-ICD motif deletion alleles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7090062	Given that miR-30a depends on autophagy to regulate IM sensitivity, we further reveal that miR-30a affects autophagy via beclin-1, a key protein required for autophagosome formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600592	H NMR CDCl3) δ 7.69 (d, J = 3.3 Hz, 2H, H-2, 6), 7.46 (d, J = 7.1 Hz, 2H, H-3, 5), 7.43–7.38 (m, 5H, H-23,24,25,26,27), 7.35 (t, J = 7.3 Hz, 1H, H-4), 5.29 (s, 2H, H-21), 4.78 (dt, J = 8.9, 4.6 Hz, 1H, H-14), 3.16–3.12 (m, 2H, H-8), 2.62–2.58 (m, 2H, H-9), 1.84 (dd, J = 9.7, 3.6 Hz, 2H, H-15), 1.75–1.72 (m, 2H, H-19), ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Moreover, the PIK3IP1 mRNA level was significantly decreased in the aforementioned AML cohort compared to the control(P<0.005)(Fig.1F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "PIK3IP1",...
PMC11078693	Such preservation of morphology should be beneficial for automated analysis with imaging tools such as Imaris and FIJI/ImageJ, which was not part of this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11506670	After 24 h, cells were fixed with ice-cold 4% paraformaldehyde for 20 min, with shaking at 40 rpm on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After",...
PMC9792775	It is still unknown if LFU has the ability to change the tumor immune microenvironment, thereby enhancing the likelihood of success in treating sarcoma with immune checkpoint inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, in some cases, a synchronic or metachronic onset of two different lymphomas in the same patient is possible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "i...
PMC10387886	The recommended protocol of antibody manufacturer (Cell Signaling) was followed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "recommended", "protocol", "of", "antibody", "manufacturer", "(", "Cell", ...
PMC11730311	Results are presented as mean of n = 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "presented", "as", "mean", "of", "n", "=", "2", "." ] } ]
PMC11742864	According to the current clinical results and meta-analysis, we consider that for patients with lung cancer, the supplementation of ω-3 LCPUFAs should be at a dose of 2–5 g/day, with EPA content higher than that of DHA; and depending on the average duration of the current clinical studies, we suggest that it is prefera...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	Cells were mixed by vortexing, and subsequently incubated at 37°C for 25 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "mixed", "by", "vortexing", ",", ...
PMC10933092	Knockdown efficiency was verified using RT-qPCR and Western blot (Figures 1A, B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Knockdown", "efficiency", "was", "verified", "using", "RT-qPCR", ...
PMC11352666	These results suggest that MRX-2843 could be useful to treat Ewing sarcoma in patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "MRX-2843", "could", "be", ...
PMC6182045	TZ97008 and LANL clade C amino acid sequences were aligned in Geneious 10.2.3 (1) to compare TZ97008 to the most common features in clade C (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	Tankyrases are telomerase-specific PARPs that can interact with target proteins and regulate a variety of cellular processes, including telomere maintenance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tankyrases", "are", ...
PMC10253973	The complexes showed luminescence in the dark and were stable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "complexes", "showed", "luminescence", "in", "the", "dark", "and", "were", "stable", ...
PMC11564405	The perfect combination of these advanced technologies is critical to revealing the subtle complexities embedded in visual data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "perfect", "combination", "of", ...
PMC10253973	This results in the disruption of DNA replication, penetrating deep into the endoplasmic reticulum and accumulating in the mitochondria, which leads to oxidative stress and apoptosis of pathological cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9275501	More importantly, the antitumor drug delivery system based on nanocarriers clearly shows the potential to overcome the problems related to traditional chemotherapy (Sohail et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9352806	And transcription factor EB (TFEB) is also a major inducer of lysosomal biogenesis and autophagosome-lysosome fusion, negatively regulated by upstream mTORC1 (Kounakis et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9874064	In conclusion, USP1 is likely to play an important role in the DNA damage response pathway, thereby becoming a promising therapeutic target for liver cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11618052	The outer mitochondrial membrane becomes permeable when the concentration of proapoptotic proteins surpasses that of antiapoptotic proteins, initiating a cascade of events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11787355	After 4 days of incubation, TCR-T cells were ready for expression analysis or coculture assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "4", "days", "of", "incubation", ",", "T...
PMC11753949	Cells were then washed 3x with PBS and incubated sequentially in i) permeabilization buffer (0.1% saponin in PBS) for 10 mins, ii) blocking buffer (2% BSA in PBS) for 1 hour at room temperature or overnight at 4 °C and iii) with primary antibodies in blocking buffer overnight at 4 °C or phalloidin in blocking buffer fo...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Optical genome mapping (OGM) is a new method based on the imaging of long DNA molecules (>250kb) labelled at specific motifs, generating a unique pattern.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9727330	Furthermore, the Raf/MEK/ERK pathway can also modulate the activity of many proteins involved in the apoptotic signal, such as Bim, Bax, Casp-9, Casp-3, and P53, which, in turn, regulate cellular autophagy and result in PCD (McCubrey et al., 2007; Khalil et al., 2020b; El-Fadl et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9599726	A small volume from the supernatant was taken for protein quantification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "small", "volume", "from", "the", "supernatant", "was", "taken", "for", "protein"...
PMC11470999	Therefore, these data indicate that CIP2A expression is closely related to melanoma progression, suggesting its oncogenic role in melanoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", ...
PMC8345486	The calibration of parameters such as autofluorescence, nonspecific isotype control binding, and equal PMT voltage allowed p53 expression level comparison between different cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9599726	Deferoxamine (DFO), another ferroptosis inhibitor, acting through the chelation of iron, also prevented lipid peroxidation in both GIST882 and GIST48 cells (Figure 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "...
PMC11621493	Activity assays revealed that PLA2G4D shows activity in the absence and presence of calcium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activity", "assays", "revealed", "that", "PLA2G4D", "shows", "activity...
PMC11269933	Oysters, as representative species in marine mollusks, are distributed worldwide and possess significant economic and ecological values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oysters", ",", "as", "representat...
PMC10882807	Moreover, circRNAs participate in cancer pathogenesis, invasion and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "circRNAs", "participate", "in", "cancer", "pathogenesis", ",", "invasion",...
PMC10454535	Although BTZ is often used to target MM cells, the treatment has been demonstrated to have adverse effects including gastrointestinal issues, fatigue, thrombocytopenia, and peripheral neuropathy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	H3K4me3: control vs. USP43 sgRNA **P < 0.0001, control vs. 14-3-3 siRNA P < 0.0001, control vs. USP43 sgRNA + 14-3-3 siRNA **P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10969097	This result is in synergy with the results presented by Doğan et al. , who described that the extracts of F. fomentarius and T. anatolicum were able to reverse MDR, increasing sensitivity to chemotherapy by inhibiting the activity of the P-gp protein in drug-resistant breast cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11733919	Lipid peroxidation, triggering ferroptotic cell death, might be initiated by acyl-coenzyme A (acyl-CoA) synthetase long-chain family member 4 (ACSL4)/ lysophosphatidylcholine acyltransferase 3 (LPCAT3)/ arachidonate 15-lipoxygenase (ALOX15)-dependent enzymatic reaction as well as Fe-dependent nonenzymatic Fenton reacti...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	Because of the stronger evolutionary pressure and weak linkage disequilibrium (LD) with common SNPs used in GWAS, finding these rare variants through population-based studies can be challenging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	H. sapiens DDX4 (residues 1–236), LAF-1 RGG (residues 1–200), and FUS Y27S mutant (residues 1–214) fragments were obtained as gBlocks (Integrated DNA Technologies).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144382	Quantified expression, using densitometry analysis, of (C-D) CRABP2, (E-F) VCAM1, (G-H) KCTD12 and (I-J) IDI1 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3888431	Additionally the transcripts were screened for possible transposable elements with RepeatMasker (version 4.0.3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", "the", "transcripts", "were", "screened", "for", ...
PMC11194678	Reaction was quenched by 200 mM Tris (pH 8.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reaction", "was", "quenched", "by", "200", "mM", "Tris", "(", "pH", "8.0", ")",...
PMC5025404	Thus, despite the lower specific productivity of the clones generated according to the second strategy, they were able to reach much higher cell density that caused better overall productivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7504302	CD26 is a type II transmembrane glycoprotein and is related with high proliferative activity as well as invasiveness in MPM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD26", "is", "a",...
PMC10443665	Overexpression of MDR1/P-gp and its function is associated with failure of chemotherapy in ALL patients (4041).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "MDR1/P-gp", "and", ...
PMC11724582	The genes in the acute and DTP groups of H1975 cells were subsequently analyzed for differential expression, and 875 upregulated genes and 538 downregulated genes were screened (Fig. 4A-B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11319300	We have shown that the MYEOV-3′-putative enhancer is located between the corresponding homologs of CCND1 and TPCN2 in 16 out of the 17 species analysed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11779605	Patient electronic medical records were searched under IRB protocol #73208 to determine the progression-free survival (PFS: months of time between date of diagnosis and date of recurrence or last follow-up) or overall survival (OS: months of time between date of diagnosis and date of death).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11388384	Transfected cells were sorted by FACS 24 h after transfection for mCherry(+) cells, recovered for two days then sorted again to generate single-cell clones of Myo10 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4685407	Homologous sequences located on both sides of the exogenous gene are used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Homologous", "sequences", "located", "on", "both", "sides", "of", "the", "exogen...
PMC11138140	Cardiac cultures from neonatal rat hearts are often contaminated with other cell types in addition to cardiomyocytes, despite methods used to increase purity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9960565	Cisplatin was also studied for comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cisplatin", "was", "also", "studied", "for", "comparison", "." ] } ]
PMC11381192	Patients were divided into high and low risk groups according to the median score calculated by the nomogram, and Kaplan–Meier curves were plotted based on this nomogram‐based stratification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591794	Cells were grown and incubated in a 75 cm cell culture flask (Thermo Fisher Scientific, Waltham, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells",...
PMC10669966	For emerging oncogenic genes that have been characterized in other cancers, we identified PAPPA , FBN2 , and METTL1 in DDLPS, POTEE and LBX1 in MLPS, and CDCA2 and TROAP in PLPS as differentially expressed genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9386809	The H NMR spectra of complex 2 showed a singlet at δ 1.00 and 1.33 ppm corresponding to the 18 hydrogens of t-butyl groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10854447	The optimal derivative was compound I (Figure 1), demonstrating equipotent antiproliferative action against a panel of five NSCLC cell lines (IC50 = 0.2–0.6 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394386	Similarly, we induced over-activation of the Wnt/β-catenin pathway by treating HeLa cells with 25 mM LiCl to stimulate transcription (Figure 4D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11543885	Remove the final wash and incubate the cells with 100 μL AF555-conjugated goat anti-rabbit IgG (H + L) secondary antibody (1: 1000 dilution) in 1% (wt/vol) BSA for 1 h at 25°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	Interestingly, IRF6 mRNA levels were lower in cells heterozygous or homozygous for the risk allele compared with the cells homozygous for the non-risk allele (Fig. 4d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8998437	Autofluorescent and apoptotic cells were excluded from the analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Autofluorescent", "and", "apoptotic", "cells", "were", "excluded", "from", "the", "analyses", "." ] }...
PMC9219615	Protein kinases regulate many cellular functions, including proliferation, mitosis, apoptosis, and metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "kinases", "regulate", "many", "cellular", "...
PMC11672617	It is thought that mitochondrial uncoupling has a natural antioxidant effect that increases the respiration rate and thus likely attenuates the production of ROS ions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11116779	Similar to SOD1, SOD2, CAT, and GPX1, PS-NPs were able to significantly induce the HMOX1 expression at all tested concentrations (Figures 3I,J).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6114978	Approximately 49% of sarcomas (73/148) demonstrate loss of MST1, 31% of sarcomas (46/148) demonstrate loss of MST2, 23% of sarcomas (34/148) demonstrate loss of LATS1 expression, and 29% of sarcomas (45/153) demonstrate loss of LATS2 (Supplementary Figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10605143	Importantly, we observed that inhibition of HSF1 using its specific inhibitor, DTHIB , reduced the proliferation of highly invasive BT-549 cells and their ability to invade Matrigel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11402217	After cell adhesion, we introduced 200 μL of fresh medium with various XD23 concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "cell", "adhesion", ",", "we", "introduced", "200",...
PMC11306331	Using Galaxy version 24.1, reads were mapped using the Spliced Transcripts Alignment to a Reference (STAR) algorithm version 2.7 and then counted using the featureCounts algorithm version 2.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	Overexpression of EZH2 is a common feature of many solid tumors, where it appears to be important for maintaining cancer stem cell populations and regulating lipid metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11209164	Absorbance readings were taken using the BioTek Microplate Reader (Agilent, Santa Clara, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Absorbance", "readings", "were", ...
PMC9429973	This is a population-based study in British Columbia, Canada.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "a", "population-based", "study", "in", "British", "Columbia", ",", "Canada", ...
PMC11627133	Minimal and maximal fluorescence intensities were normalized to 0 and 1, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Minimal", "and", "maximal", "fluorescence", "intensities", "were", "normalized", ...
PMC11701801	Furthermore, we used published ChIP-seq data (GSE108028; ref.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "used", "published", "ChIP-seq", "data", "(", "GSE108028", "...
PMC11802855	We chose the GSE24080 cohort and designated the TT2 patient group as the training set, while assigning the TT3 patient group as the validation set.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Patients who had received prior Ven were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "had", "received", "prior", "Ven", "were", "excluded", "." ] } ]
PMC11394730	This causes cell cycle arrest at the G1 phase .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "causes", "cell", "cycle", "arrest", "at", "the", "G1", "phase", "." ] } ]
PMC9429973	Ptn are consented for enrolment at their respective centres.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ptn", "are", "consented", "for", "enrolment", "at", "their", "respective", "centres", "." ] } ]
PMC11790971	And phasor mean lifetime (τ) was calculated using formula:4[12pt] $$_=_}_}$$τi,j=si,jω⋅gi,j To increase the dynamic range of phasor g and s values, we increased the frequency from 10 MHz (laser repetition rate) to 74 MHz by treating the duration of the fitting range (i.e., the analysis window of the decay curve) as one...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11185260

The IC50 values, the drug concentration resulting in 50% cell death, were interpolated from the graph of DNA concentration versus the fraction of surviving cells using SigmaPlot 11.2 (Systat Software, San Jose, CA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4443654

Genome-wide, 33% of all H1 TAD boundaries have a matching boundary in GM12878 in the same or an adjacent 40-kb bin (K562: 31%, null model: 18%; Kolmogorov–Smirnov test: D=0.26, p≈0).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5363531

Indeed, in all five clones we observed a significant reduction (> 75–80%) of luciferase levels compared to untreated condition.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed"...

PMC11623887

These findings underscore the inhibitory role of FAM122A in regulating erythroid differentiation and suggest its potential as a therapeutic target for conditions associated with GATA1 dysfunction, or as a crucial regulator for expanding red blood cells in laboratory settings.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11760643

p < 0.05; p < 0.01; no significant difference (ns).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ";", "p", "<", "0.01", ";", "no", "...

PMC11765879

An Aliquot of 10 mg of the extract powder was dissolved in 250 µL DMSO, providing a solution with a stock concentration of 40 mg/mL that was stored at 4 °C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11806106

H Concentration–response curve for dynorphine A at the KOR BRET (blue) and KOR FRET (magenta) receptor conformation sensor.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11659734

Advanced 3D mini‐tissue and mini‐organ models provide a more accurate simulation of cellular organisation and function than traditional two‐dimensional cell cultures grown in monolayers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11720107

The analysis revealed that the Harnaś cultivar is rich in apigenin, catechin, ferulic acid, isoharmentin, sinapic acid, and vanillic acid.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9917080

Incubation of selenium nanoparticles with A-172 cells for 24 h, such as sorafenib, led to the suppression of the kinase expression, and this effect increased after 48 h. The SeSo nanocomplex had effects similar to the use of sorafenib, i.e., after 24 h of treatment, the expression of kinase genes increased; however, af...

[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11409031

Ovarian cancer (OV) is a highly lethal disease that impacts the female reproductive system.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ovarian", "cancer", "(", "OV", ")", "is", "a", ...

PMC11680562

Some of the symptoms are aberrant vaginal bleeding, pelvic discomfort, and weight loss.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "of", "the", "symptoms", "are", "aberrant", "vaginal...

PMC11790599

Despite recent advances in prevention and treatment, breast cancer remains a formidable adversary, causing 670,000 deaths and 2.3 million new cases globally in 2022 (Bray et al., 2024).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10955424

Exposure to malignant ascites resulted in the elevation of cell counts in A2780cisR cells treated with RJY13 compound, while ascites derived from cirrhosis patients did not result in an increase in cell count (Fig. 1G).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11267036

Here, dihydromyricetin (DHM) dose-dependently restrained viability, apoptosis, migration, and invasion, and facilitated apoptosis of U266 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ ...

PMC6461034

ALK is a high‐ranking kinase with roughly equal evidence from both analysis arms.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ALK", "is", "a", "high‐ranking", "kinase", "with", "roughly", "equal", ...

PMC9429973

Summary/Conclusion: In our experience, single agent AZA alone was effective and well tolerated in heavily pretreated patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "In", "...

PMC9429973

Early results demonstrate promising efficacy with combination therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Early", "results", "demonstrate", "promising", "efficacy", "with", "combination", "therapy", "." ] } ]

PMC11055323

h Tumor growth curve of SW982 cell overexpressing mCherry, SS18-SSX and N12 fused SS18-SSX xenografts established in NCG mice for 21 days.

[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], ...

PMC9429973

Chromothriptic events involve multiple loci in CLL patients; 2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chromothriptic", "events", "involve", "multiple", "loci", "in", "CLL", "patients", ";", "2", ...

PMC10213199

The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis, whereas shorter gene products (isoforms 2 and 3) may promote apoptosis and cell death .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11634027

A Flip-out cassette expressing Dachs:GFP with an intervening transcriptional stop cassette flanked by FRT sites was introduced into Ds-ICD motif deletion alleles.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC7090062

Given that miR-30a depends on autophagy to regulate IM sensitivity, we further reveal that miR-30a affects autophagy via beclin-1, a key protein required for autophagosome formation.

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PMC6600592

H NMR CDCl3) δ 7.69 (d, J = 3.3 Hz, 2H, H-2, 6), 7.46 (d, J = 7.1 Hz, 2H, H-3, 5), 7.43–7.38 (m, 5H, H-23,24,25,26,27), 7.35 (t, J = 7.3 Hz, 1H, H-4), 5.29 (s, 2H, H-21), 4.78 (dt, J = 8.9, 4.6 Hz, 1H, H-14), 3.16–3.12 (m, 2H, H-8), 2.62–2.58 (m, 2H, H-9), 1.84 (dd, J = 9.7, 3.6 Hz, 2H, H-15), 1.75–1.72 (m, 2H, H-19), ...

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PMC9429973

Moreover, the PIK3IP1 mRNA level was significantly decreased in the aforementioned AML cohort compared to the control(P<0.005)(Fig.1F).

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PMC11078693

Such preservation of morphology should be beneficial for automated analysis with imaging tools such as Imaris and FIJI/ImageJ, which was not part of this study.

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PMC11506670

After 24 h, cells were fixed with ice-cold 4% paraformaldehyde for 20 min, with shaking at 40 rpm on ice.

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PMC9792775

It is still unknown if LFU has the ability to change the tumor immune microenvironment, thereby enhancing the likelihood of success in treating sarcoma with immune checkpoint inhibitors.

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PMC9429973

However, in some cases, a synchronic or metachronic onset of two different lymphomas in the same patient is possible.

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PMC10387886

The recommended protocol of antibody manufacturer (Cell Signaling) was followed.

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PMC11730311

Results are presented as mean of n = 2.

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PMC11742864

According to the current clinical results and meta-analysis, we consider that for patients with lung cancer, the supplementation of ω-3 LCPUFAs should be at a dose of 2–5 g/day, with EPA content higher than that of DHA; and depending on the average duration of the current clinical studies, we suggest that it is prefera...

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PMC11697065

Cells were mixed by vortexing, and subsequently incubated at 37°C for 25 min.

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PMC10933092

Knockdown efficiency was verified using RT-qPCR and Western blot (Figures 1A, B).

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PMC11352666

These results suggest that MRX-2843 could be useful to treat Ewing sarcoma in patients.

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PMC6182045

TZ97008 and LANL clade C amino acid sequences were aligned in Geneious 10.2.3 (1) to compare TZ97008 to the most common features in clade C (Figure 2).

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PMC6600253

Tankyrases are telomerase-specific PARPs that can interact with target proteins and regulate a variety of cellular processes, including telomere maintenance.

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PMC10253973

The complexes showed luminescence in the dark and were stable.

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PMC11564405

The perfect combination of these advanced technologies is critical to revealing the subtle complexities embedded in visual data.

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PMC10253973

This results in the disruption of DNA replication, penetrating deep into the endoplasmic reticulum and accumulating in the mitochondria, which leads to oxidative stress and apoptosis of pathological cells.

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PMC9275501

More importantly, the antitumor drug delivery system based on nanocarriers clearly shows the potential to overcome the problems related to traditional chemotherapy (Sohail et al., 2021).

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PMC9352806

And transcription factor EB (TFEB) is also a major inducer of lysosomal biogenesis and autophagosome-lysosome fusion, negatively regulated by upstream mTORC1 (Kounakis et al., 2019).

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PMC9874064

In conclusion, USP1 is likely to play an important role in the DNA damage response pathway, thereby becoming a promising therapeutic target for liver cancer.

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PMC11618052

The outer mitochondrial membrane becomes permeable when the concentration of proapoptotic proteins surpasses that of antiapoptotic proteins, initiating a cascade of events.

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PMC11787355

After 4 days of incubation, TCR-T cells were ready for expression analysis or coculture assays.

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PMC11753949

Cells were then washed 3x with PBS and incubated sequentially in i) permeabilization buffer (0.1% saponin in PBS) for 10 mins, ii) blocking buffer (2% BSA in PBS) for 1 hour at room temperature or overnight at 4 °C and iii) with primary antibodies in blocking buffer overnight at 4 °C or phalloidin in blocking buffer fo...

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PMC9429973

Optical genome mapping (OGM) is a new method based on the imaging of long DNA molecules (>250kb) labelled at specific motifs, generating a unique pattern.

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PMC9727330

Furthermore, the Raf/MEK/ERK pathway can also modulate the activity of many proteins involved in the apoptotic signal, such as Bim, Bax, Casp-9, Casp-3, and P53, which, in turn, regulate cellular autophagy and result in PCD (McCubrey et al., 2007; Khalil et al., 2020b; El-Fadl et al., 2021).

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PMC9599726

A small volume from the supernatant was taken for protein quantification.

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PMC11470999

Therefore, these data indicate that CIP2A expression is closely related to melanoma progression, suggesting its oncogenic role in melanoma.

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PMC8345486

The calibration of parameters such as autofluorescence, nonspecific isotype control binding, and equal PMT voltage allowed p53 expression level comparison between different cell lines.

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PMC9599726

Deferoxamine (DFO), another ferroptosis inhibitor, acting through the chelation of iron, also prevented lipid peroxidation in both GIST882 and GIST48 cells (Figure 2C).

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PMC11621493

Activity assays revealed that PLA2G4D shows activity in the absence and presence of calcium.

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PMC11269933

Oysters, as representative species in marine mollusks, are distributed worldwide and possess significant economic and ecological values.

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PMC10882807

Moreover, circRNAs participate in cancer pathogenesis, invasion and metastasis.

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PMC10454535

Although BTZ is often used to target MM cells, the treatment has been demonstrated to have adverse effects including gastrointestinal issues, fatigue, thrombocytopenia, and peripheral neuropathy .

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PMC11377827

H3K4me3: control vs. USP43 sgRNA ****P < 0.0001, control vs. 14-3-3 siRNA ****P < 0.0001, control vs. USP43 sgRNA + 14-3-3 siRNA ****P < 0.0001.

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PMC10969097

This result is in synergy with the results presented by Doğan et al. , who described that the extracts of F. fomentarius and T. anatolicum were able to reverse MDR, increasing sensitivity to chemotherapy by inhibiting the activity of the P-gp protein in drug-resistant breast cancer cells .

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PMC11733919

Lipid peroxidation, triggering ferroptotic cell death, might be initiated by acyl-coenzyme A (acyl-CoA) synthetase long-chain family member 4 (ACSL4)/ lysophosphatidylcholine acyltransferase 3 (LPCAT3)/ arachidonate 15-lipoxygenase (ALOX15)-dependent enzymatic reaction as well as Fe-dependent nonenzymatic Fenton reacti...

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PMC7887261

Because of the stronger evolutionary pressure and weak linkage disequilibrium (LD) with common SNPs used in GWAS, finding these rare variants through population-based studies can be challenging.

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PMC11342785

H. sapiens DDX4 (residues 1–236), LAF-1 RGG (residues 1–200), and FUS Y27S mutant (residues 1–214) fragments were obtained as gBlocks (Integrated DNA Technologies).

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PMC11144382

Quantified expression, using densitometry analysis, of (C-D) CRABP2, (E-F) VCAM1, (G-H) KCTD12 and (I-J) IDI1 expression.

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PMC3888431

Additionally the transcripts were screened for possible transposable elements with RepeatMasker (version 4.0.3).

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PMC11194678

Reaction was quenched by 200 mM Tris (pH 8.0).

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PMC5025404

Thus, despite the lower specific productivity of the clones generated according to the second strategy, they were able to reach much higher cell density that caused better overall productivity.

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PMC7504302

CD26 is a type II transmembrane glycoprotein and is related with high proliferative activity as well as invasiveness in MPM cells.

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PMC10443665

Overexpression of MDR1/P-gp and its function is associated with failure of chemotherapy in ALL patients (4041).

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PMC11724582

The genes in the acute and DTP groups of H1975 cells were subsequently analyzed for differential expression, and 875 upregulated genes and 538 downregulated genes were screened (Fig. 4A-B).

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PMC11319300

We have shown that the MYEOV-3′-putative enhancer is located between the corresponding homologs of CCND1 and TPCN2 in 16 out of the 17 species analysed.

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PMC11779605

Patient electronic medical records were searched under IRB protocol #73208 to determine the progression-free survival (PFS: months of time between date of diagnosis and date of recurrence or last follow-up) or overall survival (OS: months of time between date of diagnosis and date of death).

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PMC11388384

Transfected cells were sorted by FACS 24 h after transfection for mCherry(+) cells, recovered for two days then sorted again to generate single-cell clones of Myo10 cells.

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PMC4685407

Homologous sequences located on both sides of the exogenous gene are used.

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PMC11138140

Cardiac cultures from neonatal rat hearts are often contaminated with other cell types in addition to cardiomyocytes, despite methods used to increase purity .

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PMC9960565

Cisplatin was also studied for comparison.

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PMC11381192

Patients were divided into high and low risk groups according to the median score calculated by the nomogram, and Kaplan–Meier curves were plotted based on this nomogram‐based stratification.

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PMC11591794

Cells were grown and incubated in a 75 cm cell culture flask (Thermo Fisher Scientific, Waltham, MA, USA).

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PMC10669966

For emerging oncogenic genes that have been characterized in other cancers, we identified PAPPA , FBN2 , and METTL1 in DDLPS, POTEE and LBX1 in MLPS, and CDCA2 and TROAP in PLPS as differentially expressed genes.

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PMC9386809

The H NMR spectra of complex 2 showed a singlet at δ 1.00 and 1.33 ppm corresponding to the 18 hydrogens of t-butyl groups.

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PMC10854447

The optimal derivative was compound I (Figure 1), demonstrating equipotent antiproliferative action against a panel of five NSCLC cell lines (IC50 = 0.2–0.6 µM).

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PMC11394386

Similarly, we induced over-activation of the Wnt/β-catenin pathway by treating HeLa cells with 25 mM LiCl to stimulate transcription (Figure 4D).

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PMC11543885

Remove the final wash and incubate the cells with 100 μL AF555-conjugated goat anti-rabbit IgG (H + L) secondary antibody (1: 1000 dilution) in 1% (wt/vol) BSA for 1 h at 25°C.

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PMC11538390

Interestingly, IRF6 mRNA levels were lower in cells heterozygous or homozygous for the risk allele compared with the cells homozygous for the non-risk allele (Fig. 4d).

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PMC8998437

Autofluorescent and apoptotic cells were excluded from the analyses.

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PMC9219615

Protein kinases regulate many cellular functions, including proliferation, mitosis, apoptosis, and metabolism.

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PMC11672617

It is thought that mitochondrial uncoupling has a natural antioxidant effect that increases the respiration rate and thus likely attenuates the production of ROS ions .

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PMC11116779

Similar to SOD1, SOD2, CAT, and GPX1, PS-NPs were able to significantly induce the HMOX1 expression at all tested concentrations (Figures 3I,J).

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PMC6114978

Approximately 49% of sarcomas (73/148) demonstrate loss of MST1, 31% of sarcomas (46/148) demonstrate loss of MST2, 23% of sarcomas (34/148) demonstrate loss of LATS1 expression, and 29% of sarcomas (45/153) demonstrate loss of LATS2 (Supplementary Figure 1C).

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PMC10605143

Importantly, we observed that inhibition of HSF1 using its specific inhibitor, DTHIB , reduced the proliferation of highly invasive BT-549 cells and their ability to invade Matrigel.

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PMC11402217

After cell adhesion, we introduced 200 μL of fresh medium with various XD23 concentrations.

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PMC11306331

Using Galaxy version 24.1, reads were mapped using the Spliced Transcripts Alignment to a Reference (STAR) algorithm version 2.7 and then counted using the featureCounts algorithm version 2.0.

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PMC11696576

Overexpression of EZH2 is a common feature of many solid tumors, where it appears to be important for maintaining cancer stem cell populations and regulating lipid metabolism.

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PMC11209164

Absorbance readings were taken using the BioTek Microplate Reader (Agilent, Santa Clara, CA, USA).

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PMC9429973

This is a population-based study in British Columbia, Canada.

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PMC11627133

Minimal and maximal fluorescence intensities were normalized to 0 and 1, respectively.

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PMC11701801

Furthermore, we used published ChIP-seq data (GSE108028; ref.

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PMC11802855

We chose the GSE24080 cohort and designated the TT2 patient group as the training set, while assigning the TT3 patient group as the validation set.

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PMC9429973

Patients who had received prior Ven were excluded.

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PMC11394730

This causes cell cycle arrest at the G1 phase .

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PMC9429973

Ptn are consented for enrolment at their respective centres.

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PMC11790971

And phasor mean lifetime (τ) was calculated using formula:4[12pt] $$_=_}_}$$τi,j=si,jω⋅gi,j To increase the dynamic range of phasor g and s values, we increased the frequency from 10 MHz (laser repetition rate) to 74 MHz by treating the duration of the fitting range (i.e., the analysis window of the decay curve) as one...

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