OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11397654	On the other hand, functionalisation with 3-(trifluoromethyl)aniline did not yield particularly active derivatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "functionalisation", "with", "...
PMC9429973	Methods: Patients (pts) with diagnosis of any type of lymphoma in the need of starting therapy in our hospital were included in our study between 1st Jan 2019 and 31st Dec 2020.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	Since the activation of these signalling pathways is based on an altered localisation within the cell compartments, the translocation of the proteins was quantified based on high-resolution microscopy (for exemplary images, see Figure S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	P < 0.05 was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", "was", "considered", "statistically", "significant", "." ] } ]
PMC9429973	Dose-dependent CRC01 expansion was observed; median Tmax was 15.4, 15.8, 11.0 days at DL1, DL2 & DL3 each; median Cmax was 18,003, 30,103, 53,688 copies/ug gDNA at DL1, DL2 & DL3 each; median AUC0-28day was 679,125, 1,110,108, 2,852,235 copies/ug gDNA at DL1, DL2 & DL3 respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600592	A series of cyclohexyl (E)-4-(alkyl imino)-4-(4-substituted-phenyl) butanoates possessed obvious and significant anti-HBV activities with SIHBsAg values from 0.89 to 13.41 and SIHBeAg values from 1.06 to 17.34 compared to control lamivudine in SIHBsAg values 2.20 and SIHBeAg values 2.07.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Navitoclax dose reductions and interruptions were experienced by 15 patients (50%) and 16 patients (53%), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Navitoc...
PMC10907726	This enables the targeting of EGFR for the treatment of proliferative diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "enables", "the", "targeting", "of", "EGFR", "for", "the", "treatment", ...
PMC11269792	The experiments were approved by the Institutional Animal Care and Use Committee of the Affiliated Hospital of Inner Mongolia Minzu University (n° 201306YT2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	ATAD2 knockdown significantly inhibited cell proliferation and induced a G1-phase cell cycle arrest in T-ALL cells (P<0.01) (Fig 1I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ATAD2",...
PMC7351993	First, the RIACS is applicable to quality control of cells for cell therapies such as hematopoietic stem cell transplantation, mesenchymal stem cell therapy, CAR-T therapy, and hiPSC therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10810426	We also looked at virus spread in serum-starved and the reverse transcription inhibitor zidovudine/azidothymidine (AZT)-treated cells, by measuring the level of MLV envelope sequences in genomic DNA at different times post-infection (Fig 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329074	The proteins were then separated by SDS-PAGE and transferred to a polyvinylidene fluoride membrane, and the membrane was blocked in 5% bovine serum albumin for 1 h. The primary anti-YBX3 antibody (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	The results are presented as the mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "are", "presented", "as", "the", "mean", "±", "SD", "." ] } ]
PMC11047729	This substance lowers the activity of telomerase and down-regulates the expression of hTERT in a dose-dependent manner .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "substance", "lowers", "the", "activity", ...
PMC7917457	Systemic tumor-specific T cell responses were analyzed with the ELISpot assay from the spleens of treated mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Systemic", "tumor-specific", "T", "cell", "respon...
PMC11594806	Experimental knockdown of CD73 by this group led to reduced pathogenic growth of FN-RMS both in vitro and in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experimental", "knockdown", ...
PMC11798926	Many studies highlight the importance of dynamic AMPAR trafficking to and from synapses in the rapid modulation of synaptic strength during plasticity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "stud...
PMC11400680	Accurate segmentation is helpful for extracting precise features from the cellular structures and leads to more accurate analysis results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accurate", "segmentation", "is", ...
PMC9429973	M. I. Pinto, B. Marques, D. Coelho, P. Martinho, T. Fidalgo, J. P. Carda, A. B. Sarmento Ribeiro Faculty of Medicine, University of Coimbra; Clinical Hematology Department, Centro Hospitalar e Universitário de Coimbra; Coimbra Institute for Clinical and Biomedical Research (iCBR); University Clinic of Hematology and La...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	One of the effective approaches to develop personalized treatment is to replicate the disease in laboratory using 3D cell models based on patient-derived tumors following debulking surgery, and test various treatment options for the specific cancer phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9275501	Carrier-free nano-systems coupled by ester or disulfide bonds can release drugs in a fixed proportion, which have better antitumor effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Carrier-free", "nano-sy...
PMC11594074	The complexes DNMT1–compound 3 and DNMT1–compound 4 showed similar ranges of hydrogen bonds, fluctuating between 0 to 3, and for the complex DNMT1–compound 2, the range is between 0 and 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	In contrast, compound 3 interacts with only 10 amino acids (48%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "compound", "3", "interacts", "with",...
PMC9429973	The identification of its risk factors allows us to improve the therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "identification", "of", "its", "risk", "factors", "allows", "us", ...
PMC11721587	WB analysis of SUMOylation of exogenously expressed WT and mutant Ulk3-HA in NIH3T3 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "WB", "analysis", "of", "SUMOylation", "of", "exogenously...
PMC7053076	NF-κB1 and NF-κB2 are the precursor forms of p50 and p52, respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NF-κB1", "and", "NF-κB2", "are", "the", "precursor", "forms", "of", "...
PMC11467964	Malignancy can change their integrin signaling patterns to adapt to foreign extracellular matrix or overexpress extracellular matrix‐related protein to live.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Malignancy", "can", "change"...
PMC9429973	In general, most infections had respiratory origin (37%) followed by urinary tract (16%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "general", ",", "...
PMC9119314	50 nL of the test and control compound diluted in DMSO was added and incubated for 24 h. Thereafter, P. berghei sporozoites (P. berghei ANKA GFP-Luc-SMcon) freshly obtained by dissecting salivary glands of infected A. stephensi mosquitoes were added to each well at a density of 1 × 10 per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	For tetramer dilution experiments, CD3 Jurkat cells (BV421 anti-human CD3, 300434) were isolated, and then stained for tetramer positive-control (APC QuickSwitch, MBL International) and tetramer negative-control (PE QuickSwitch, MBL International).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10366908	After washing with phosphate-buffered saline (PBS), the antibodies were eluted with an IgG elution buffer (Thermo Fisher Scientific Inc.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4005030	Protocatechuic aldehyde (PA), isolated from the aqueous extract of the root of Salvia miltiorrhiza, an herb used in traditional Chinese medicine which has been used to treat a variety of vascular diseases, was tested on the migration and proliferation of VSMCs and platelets due to platelet-derived growth factor (PDGF).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	Cumulative data of three independent experiments performed in duplicates or quadruplicates (mean ± SD, ONE WAY ANOVA, Turkey’s multiple comparison test, ****p ≤ 0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	OGs oncogenes, TSGs tumor suppressor genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OGs", "oncogenes", ",", "TSGs", "tumor", "suppressor", "genes", "." ] } ]
PMC10988555	complexes were able to internalize A2780 cancer cells by passive diffusion and also via an active mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "complexes", "were", "able", "to", "internalize", ...
PMC10734950	Cells in the process of apoptosis demonstrate a distinct morphological trait, DNA fragmentation, thus confirming our outcomes. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "in", "the", "...
PMC11407042	Replace the water in the water bath and heat the water to 100°C for 4–5 h. Wipe the incubator and other devices in the cell culture room with 70% EtOH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11643491	However, many methods are not sufficiently robust and may not be suitable for drug-loaded carriers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "many", "methods", "are", "not", ...
PMC11698348	Cells were counterstained with DAPI (blue).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "counterstained", "with", "DAPI", "(", "blue", ")", "." ] } ]
PMC9503669	2C inhibited Nef-dependent activation of the myeloid Src-family member Hck in vitro and prevent interaction of Nef with Lyn and Src, two other Src-family members susceptible to activation by Nef .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11752767	The prior identification of tumor-associated antigens underlies the foundation of this process.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prior", "identification", "of", "tumor-associated", "antigens", "underlies", "t...
PMC8567602	HSSYII-HA–tagged was provided by A. Banito (30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HSSYII-HA", "–", "tagged", "was", "provided", "by", "A.", "Banito", "(", "30", ...
PMC11394112	Given the low response rates to current therapy, alternative treatment strategies are necessary to improve patient outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "the", "low", "response", "rat...
PMC10654497	The gene mutations in 451 individuals with lung cancer were examined using the “maftools” function in R software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gene", "mutations", ...
PMC9454178	Moreover, OSR1 overexpression reversed the inhibition of c-KIT expression induced by CDK7 knockdown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "OSR1", "overexpression", "reversed", "the", "inhibiti...
PMC11411004	CHO cell lines display epigenetic features or chromatin marks associated with recombinant mRNA expression during long-term culture, and the cell lines with the highest recombinant protein mRNA expression are significantly characterized by the enrichment of histone-modified H3K9ac (Veith et al. 2016).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721295	We identified statistically significant changes for the expression of Cxcl5; a similar trend, albeit not statistically significant, was identified for Cxcl1 and Cxcl2, indicating that fibroblast phenotype and paracrine signals can change upon incubation with TCM (Figure 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We previously reported initial safety and efficacy results of this phase 1b study investigating ibr + obin in R/R CLL (Davids et al., EHA 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267036	After DHM treatment, the E-cadherin level was increased and the N-cadherin level was decreased in U266 and RPMI-8226 cells, suggesting the inhibitory effects of DHM on epithelial-mesenchymal transition (EMT) in MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC6364197	3D scaffold needs some properties to better mimic the bone marrow environment, such as adequate pore size, interconnected pores and high surface area, which will facilitate cells penetration and the formation of cellular associations (5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11626627	Proposed model for a feedback loop formation of the ERβ/circATP2B1/miR-204–3p/TWIST1 axis is involved in the regulation of EMT in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proposed", "model", "for", ...
PMC11783017	All the mice were anesthetized with isoflurane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "mice", "were", "anesthetized", "with", "isoflurane", "." ] } ]
PMC11507371	Overall, these findings indicate that CAP treatment selectively and dose-dependently activates NF-κB signalling in A431 cells via the canonical pathway, resulting in apoptosis induction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11337594	To identify differentially expressed genes (DEGs), criteria were established for genes with a log2 (fold change) > 1 and Q < 0.001 to be considered DEGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910	The slides were washed with double-distilled water and PBS and mounted with coverslips by using Histomount (National Diagnostics, GA, USA) upon complete drying.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: A total of 186 patients with hematological malignancies who underwent a first allo-SCT from an HLA-matched (10/10) or mismatched (9/10 or 8/10) unrelated donor from Chinese bone marrow bank and Taiwan Tzu Chi bone marrow bank following ATG-containing condition was retrospectively analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190538	As previously mentioned, C-PC's interaction with the polar head of lecithin was confirmed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "previously", "mentioned", ",", "C-PC", "'s", "interac...
PMC6163708	BCL-2, another important antiapoptotic protein, was abundantly present in the majority of cell lines, however, in some tumors its expression was completely lacking, independently of the tumor type.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11389534	The immune system is pivotal in maintaining physiological homeostasis by selectively eliminating invaded microorganisms and clearing aberrant or damaged cellular components.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "immune", "...
PMC7022782	However, as reported in the literature , during fluorescence-guided surgery, ICG fluorescence is detected with a near-infrared camera system, the Photodynamic Eye; as only emissions over 820 nm are detected, the peak at 785 nm does not interfere during the intraoperative visualization of ICG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	n = 6.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "n", "=", "6", "." ] } ]
PMC11577421	Cells were incubated with NPs (0.16 nM for bare and 3 nM for NP_BSA−) for 4 h in culture medium, washed to remove excess particles, then analyzed by flow cytometry. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	On d+28 after HSCT, 43 pts (52%) had reached morphologic leukemia free state (MLFS), CR with incomplete count recovery (CRi) or CR, which was not associated with better OS or EFS (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This observation is consistent with the dominant inheritance pattern of WHIM syndrome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "observation", "is", "consistent", "with", "the", "dominant", "inheritance", ...
PMC6450504	0.5%PEIPOS/PTX (?)	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "0.5%PEIPOS/PTX", "(", "?", ")" ] } ]
PMC11696576	mTOR is the central kinase component of two important signaling hubs (mTORC1 and mTORC2) that maintain metabolic homeostasis and regulation of cPLA2α by mTOR and vice versa have been described before.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10743717	17β-HSD10 also serves as a component of RNase P necessary for mitochondrial tRNA maturation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "17β-HSD10", "also", "serves", "as", "a", "component", "of", "RNa...
PMC11738017	As expected, the higher E:T ratio of 3:1 led to improved killing of the target cells irrespective of their membrane BCMA density or sBCMA levels (Figure 3H, right vs left panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	Left: Representative images showing the distribution of TFEB in COS7 cells expressing PEGFP-C3, GFP-STAU1 WT, 5KE, or HKΔRBD4, as detected by immunoflurescence using TFEB antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	The mutagenesis plasmid (MP6 – Addgene #69669) provides increased mutagenesis rates by expressing proteins involved in mismatch repair (ugi and SeqA), DNA base excision (dam and cda1), DNA base selection (emrR), and proofreading (dnaQ926) under the control of the arabinose inducible pBAD system (40).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267036	Therefore, this study explored the effects of DHM on MM and related mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "this", "study", "explored", "the", "effects", ...
PMC11257988	Nevertheless, KS-58 is an attractive lead molecule for developing new cancer drugs that target KRASG12D .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "KS-58", "is", "an", "attractive",...
PMC9014716	Moreover, there was a mild down-regulation in the relationship between miR-224-5 and ABCB1 mRNA, even though miR-224-5p can directly target ABCB1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7723249	In the present study, we have established a more relevant in vitro model system based on human Caco-2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "the", "presen...
PMC11758416	For example, if the lowest count of T cells recovered per condition is 9E4 T cells, then the number of T cells per well should be 4.5E4 T cells each in duplicate (to allow for a technical replicate).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656657	p < 0.05, p < 0.01, *p < 0.001 In summary, our findings demonstrate that tumor-derived G-CSF is primarily responsible for the robust expansion of both monocytic and PMN-MDSCs in the xenograft OS NSG mouse model, highlighting the significant indirect immunomodulatory role of G-CSF in the sarcoma microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9504875	V proteins of paramyxoviruses, including human parainfluenza virus type 2 (hPIV-2), PIV-5, and mumps virus, bind to MDA5 and LGP2 to suppress the production of type I IFN .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Encapsulation of stroma cells within 3D constructs mimic accurately tumor microenvironment as these cells secrete growth factors and ECM components needed for the tumor growth and migration potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8409415	The A2780 mock cells expressed progressively higher CD70 mRNA expression at 1 h (1.63, P = .04) and 2 h (2.99, P < .01) of treatment compared to the corresponding untreated cells.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10719213	Each biological replicate was maintained in either duplicate or triplicate for the duration of each experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "biological", "replicate", "was", "maintained", ...
PMC11661040	Compared to decades ago, the 5-year survival rate for patients with osteosarcoma after standard treatment (including extensive surgical resection, neoadjuvant chemotherapy, and adjuvant chemotherapy) has increased from less than 20% to about 65%(Berner et al. 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	We brought candidate solubilizing proteins to 3xFUS droplets using the blue-light sensitive dimerization pair, iLID/SspB. Solubilizing domain schematic shows MBP (PDB structure 1FQC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7053076	The determination of anti-proliferative activity of U-332 and BGD was performed by the MTT assay, according to the Mosmann method, as described elsewhere .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9927933	We next examined whether UBE2C is under Kras regulation, and found that indeed ectopic overexpression of Kras significantly increased UBE2C at both the mRNA and protein levels without affecting UBE2S levels (Figure 2A and Supplemental Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687663	It offers statistics on the molecule’s accessible surface area based on the quantity and variety of atoms it contains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "offers", "statistics",...
PMC11760643	CDC of RPMI 8226 and J774 cells or freshly isolated PBMCs was performed using a variation of the method above.	[ { "tags": [ "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CDC", "...
PMC11806182	C Leave-one-out sensitivity analysis for PCOS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Leave-one-out", "sensitivity", "analysis", "for", "PCOS", "." ] } ]
PMC11392912	Further, we conducted in vivo studies using collagen-induced arthritic (CIA) rat models, and validated its therapeutic potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "w...
PMC11380454	Finally, we performed preclinical experiments with either SAS or AS101 to explore their effects on B16/F10 melanoma-bearing mice either alone or in combination with anti-PD-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11244823	Serum No. 62 with no apparent antibodies against EHV-1 and EHV-4 was important to determine the negative cut-off in our newly developed LIPS assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11674891	Notably, genes promoting metastasis in various cancer types were significantly enriched in the GRPR-overexpressing cells (FDR < 0.25, Figure 4a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11612794	As these two Mis12C-binding regions of CENP-T seem important for the CENP-T-Mis12C interaction, we further analyzed the molecular details of the CENP-T-Mis12C interaction and its significance in CENP-C DT40 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8526701	C GIST-T1 cells were treated with GSK602 combined with imatinib at indicated concentration for 48 h. Cell viability was analyzed by MTT.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11496491	Fig. 6GO directed acyclic graph analysis results in terms of cell components.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "6GO", "directed", "acyclic", "graph", "analysis", "results", "in", "term...
PMC11615101	Densitometric analysis of WB after normalization to GAPDH showed increased levels of STX3 (Figure 5B), STX4 (Figure 5C), TLR-4 (Figure 5D), and TLR-2 (Figure 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	Prior to delving deeper into the intracellular mechanism of ACYP2 in HCC, we established that ACYP2 exhibits a dual localization pattern, occurring simultaneously in the nucleus and cytoplasm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10900886	Prevention of virus spread to and amplification in lymphoid tissues can therefore prevent the development of a subsequent viremia and severe extra-respiratory complications caused by EV-D68.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8557138	For example, during the process of fabrication, micro-molds, sacrificial materials, liquid templates provide support to geometries inside hydrogel materials (McNulty et al. 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	Finally, by time-lapse holography, we have demonstrated for the first time that there is an increased thickness or height in dividing or apoptotic cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11397654

On the other hand, functionalisation with 3-(trifluoromethyl)aniline did not yield particularly active derivatives.

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PMC9429973

Methods: Patients (pts) with diagnosis of any type of lymphoma in the need of starting therapy in our hospital were included in our study between 1st Jan 2019 and 31st Dec 2020.

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PMC11507371

Since the activation of these signalling pathways is based on an altered localisation within the cell compartments, the translocation of the proteins was quantified based on high-resolution microscopy (for exemplary images, see Figure S1).

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PMC11762280

P < 0.05 was considered statistically significant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", "was", "considered", "statistically", "significant", "." ] } ]

PMC9429973

Dose-dependent CRC01 expansion was observed; median Tmax was 15.4, 15.8, 11.0 days at DL1, DL2 & DL3 each; median Cmax was 18,003, 30,103, 53,688 copies/ug gDNA at DL1, DL2 & DL3 each; median AUC0-28day was 679,125, 1,110,108, 2,852,235 copies/ug gDNA at DL1, DL2 & DL3 respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6600592

A series of cyclohexyl (E)-4-(alkyl imino)-4-(4-substituted-phenyl) butanoates possessed obvious and significant anti-HBV activities with SIHBsAg values from 0.89 to 13.41 and SIHBeAg values from 1.06 to 17.34 compared to control lamivudine in SIHBsAg values 2.20 and SIHBeAg values 2.07.

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PMC9429973

Navitoclax dose reductions and interruptions were experienced by 15 patients (50%) and 16 patients (53%), respectively.

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PMC10907726

This enables the targeting of EGFR for the treatment of proliferative diseases .

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PMC11269792

The experiments were approved by the Institutional Animal Care and Use Committee of the Affiliated Hospital of Inner Mongolia Minzu University (n° 201306YT2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

ATAD2 knockdown significantly inhibited cell proliferation and induced a G1-phase cell cycle arrest in T-ALL cells (P<0.01) (Fig 1I).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ATAD2",...

PMC7351993

First, the RIACS is applicable to quality control of cells for cell therapies such as hematopoietic stem cell transplantation, mesenchymal stem cell therapy, CAR-T therapy, and hiPSC therapy.

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PMC10810426

We also looked at virus spread in serum-starved and the reverse transcription inhibitor zidovudine/azidothymidine (AZT)-treated cells, by measuring the level of MLV envelope sequences in genomic DNA at different times post-infection (Fig 1B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10329074

The proteins were then separated by SDS-PAGE and transferred to a polyvinylidene fluoride membrane, and the membrane was blocked in 5% bovine serum albumin for 1 h. The primary anti-YBX3 antibody (cat.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10994876

The results are presented as the mean ± SD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "are", "presented", "as", "the", "mean", "±", "SD", "." ] } ]

PMC11047729

This substance lowers the activity of telomerase and down-regulates the expression of hTERT in a dose-dependent manner .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "substance", "lowers", "the", "activity", ...

PMC7917457

Systemic tumor-specific T cell responses were analyzed with the ELISpot assay from the spleens of treated mice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Systemic", "tumor-specific", "T", "cell", "respon...

PMC11594806

Experimental knockdown of CD73 by this group led to reduced pathogenic growth of FN-RMS both in vitro and in vivo.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experimental", "knockdown", ...

PMC11798926

Many studies highlight the importance of dynamic AMPAR trafficking to and from synapses in the rapid modulation of synaptic strength during plasticity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "stud...

PMC11400680

Accurate segmentation is helpful for extracting precise features from the cellular structures and leads to more accurate analysis results.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accurate", "segmentation", "is", ...

PMC9429973

M. I. Pinto, B. Marques, D. Coelho, P. Martinho, T. Fidalgo, J. P. Carda, A. B. Sarmento Ribeiro Faculty of Medicine, University of Coimbra; Clinical Hematology Department, Centro Hospitalar e Universitário de Coimbra; Coimbra Institute for Clinical and Biomedical Research (iCBR); University Clinic of Hematology and La...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7823217

One of the effective approaches to develop personalized treatment is to replicate the disease in laboratory using 3D cell models based on patient-derived tumors following debulking surgery, and test various treatment options for the specific cancer phenotype.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9275501

Carrier-free nano-systems coupled by ester or disulfide bonds can release drugs in a fixed proportion, which have better antitumor effect.

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PMC11594074

The complexes DNMT1–compound 3 and DNMT1–compound 4 showed similar ranges of hydrogen bonds, fluctuating between 0 to 3, and for the complex DNMT1–compound 2, the range is between 0 and 2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11594074

In contrast, compound 3 interacts with only 10 amino acids (48%).

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PMC9429973

The identification of its risk factors allows us to improve the therapeutic strategies.

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PMC11721587

WB analysis of SUMOylation of exogenously expressed WT and mutant Ulk3-HA in NIH3T3 cells. (

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PMC7053076

NF-κB1 and NF-κB2 are the precursor forms of p50 and p52, respectively .

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PMC11467964

Malignancy can change their integrin signaling patterns to adapt to foreign extracellular matrix or overexpress extracellular matrix‐related protein to live.

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PMC9429973

In general, most infections had respiratory origin (37%) followed by urinary tract (16%).

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PMC9119314

50 nL of the test and control compound diluted in DMSO was added and incubated for 24 h. Thereafter, P. berghei sporozoites (P. berghei ANKA GFP-Luc-SMcon) freshly obtained by dissecting salivary glands of infected A. stephensi mosquitoes were added to each well at a density of 1 × 10 per well.

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PMC11785489

For tetramer dilution experiments, CD3 Jurkat cells (BV421 anti-human CD3, 300434) were isolated, and then stained for tetramer positive-control (APC QuickSwitch, MBL International) and tetramer negative-control (PE QuickSwitch, MBL International).

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PMC10366908

After washing with phosphate-buffered saline (PBS), the antibodies were eluted with an IgG elution buffer (Thermo Fisher Scientific Inc.).

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PMC4005030

Protocatechuic aldehyde (PA), isolated from the aqueous extract of the root of Salvia miltiorrhiza, an herb used in traditional Chinese medicine which has been used to treat a variety of vascular diseases, was tested on the migration and proliferation of VSMCs and platelets due to platelet-derived growth factor (PDGF).

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PMC9878562

Cumulative data of three independent experiments performed in duplicates or quadruplicates (mean ± SD, ONE WAY ANOVA, Turkey’s multiple comparison test, ****p ≤ 0.0001).

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PMC11748335

OGs oncogenes, TSGs tumor suppressor genes.

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PMC10988555

complexes were able to internalize A2780 cancer cells by passive diffusion and also via an active mechanism.

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PMC10734950

Cells in the process of apoptosis demonstrate a distinct morphological trait, DNA fragmentation, thus confirming our outcomes. .

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PMC11407042

Replace the water in the water bath and heat the water to 100°C for 4–5 h. Wipe the incubator and other devices in the cell culture room with 70% EtOH.

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PMC11643491

However, many methods are not sufficiently robust and may not be suitable for drug-loaded carriers.

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PMC11698348

Cells were counterstained with DAPI (blue).

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PMC9503669

2C inhibited Nef-dependent activation of the myeloid Src-family member Hck in vitro and prevent interaction of Nef with Lyn and Src, two other Src-family members susceptible to activation by Nef .

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PMC11752767

The prior identification of tumor-associated antigens underlies the foundation of this process.

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PMC8567602

HSSYII-HA–tagged was provided by A. Banito (30).

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PMC11394112

Given the low response rates to current therapy, alternative treatment strategies are necessary to improve patient outcomes.

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PMC10654497

The gene mutations in 451 individuals with lung cancer were examined using the “maftools” function in R software.

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PMC9454178

Moreover, OSR1 overexpression reversed the inhibition of c-KIT expression induced by CDK7 knockdown.

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PMC11411004

CHO cell lines display epigenetic features or chromatin marks associated with recombinant mRNA expression during long-term culture, and the cell lines with the highest recombinant protein mRNA expression are significantly characterized by the enrichment of histone-modified H3K9ac (Veith et al. 2016).

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PMC11721295

We identified statistically significant changes for the expression of Cxcl5; a similar trend, albeit not statistically significant, was identified for Cxcl1 and Cxcl2, indicating that fibroblast phenotype and paracrine signals can change upon incubation with TCM (Figure 6C).

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PMC9429973

We previously reported initial safety and efficacy results of this phase 1b study investigating ibr + obin in R/R CLL (Davids et al., EHA 2020).

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PMC11267036

After DHM treatment, the E-cadherin level was increased and the N-cadherin level was decreased in U266 and RPMI-8226 cells, suggesting the inhibitory effects of DHM on epithelial-mesenchymal transition (EMT) in MM.

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PMC6364197

3D scaffold needs some properties to better mimic the bone marrow environment, such as adequate pore size, interconnected pores and high surface area, which will facilitate cells penetration and the formation of cellular associations (5).

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PMC11626627

Proposed model for a feedback loop formation of the ERβ/circATP2B1/miR-204–3p/TWIST1 axis is involved in the regulation of EMT in ccRCC.

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PMC11783017

All the mice were anesthetized with isoflurane.

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PMC11507371

Overall, these findings indicate that CAP treatment selectively and dose-dependently activates NF-κB signalling in A431 cells via the canonical pathway, resulting in apoptosis induction.

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PMC11337594

To identify differentially expressed genes (DEGs), criteria were established for genes with a log2 (fold change) > 1 and Q < 0.001 to be considered DEGs.

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PMC11129910

The slides were washed with double-distilled water and PBS and mounted with coverslips by using Histomount (National Diagnostics, GA, USA) upon complete drying.

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PMC9429973

Methods: A total of 186 patients with hematological malignancies who underwent a first allo-SCT from an HLA-matched (10/10) or mismatched (9/10 or 8/10) unrelated donor from Chinese bone marrow bank and Taiwan Tzu Chi bone marrow bank following ATG-containing condition was retrospectively analyzed.

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PMC11190538

As previously mentioned, C-PC's interaction with the polar head of lecithin was confirmed.

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PMC6163708

BCL-2, another important antiapoptotic protein, was abundantly present in the majority of cell lines, however, in some tumors its expression was completely lacking, independently of the tumor type.

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PMC11389534

The immune system is pivotal in maintaining physiological homeostasis by selectively eliminating invaded microorganisms and clearing aberrant or damaged cellular components.

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PMC7022782

However, as reported in the literature , during fluorescence-guided surgery, ICG fluorescence is detected with a near-infrared camera system, the Photodynamic Eye; as only emissions over 820 nm are detected, the peak at 785 nm does not interfere during the intraoperative visualization of ICG.

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PMC11746948

n = 6.

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PMC11577421

Cells were incubated with NPs (0.16 nM for bare and 3 nM for NP_BSA−) for 4 h in culture medium, washed to remove excess particles, then analyzed by flow cytometry. (

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PMC9429973

On d+28 after HSCT, 43 pts (52%) had reached morphologic leukemia free state (MLFS), CR with incomplete count recovery (CRi) or CR, which was not associated with better OS or EFS (Figure 1B).

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PMC9429973

This observation is consistent with the dominant inheritance pattern of WHIM syndrome.

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PMC6450504

0.5%PEIPOS/PTX (?)

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PMC11696576

mTOR is the central kinase component of two important signaling hubs (mTORC1 and mTORC2) that maintain metabolic homeostasis and regulation of cPLA2α by mTOR and vice versa have been described before.

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PMC10743717

17β-HSD10 also serves as a component of RNase P necessary for mitochondrial tRNA maturation.

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PMC11738017

As expected, the higher E:T ratio of 3:1 led to improved killing of the target cells irrespective of their membrane BCMA density or sBCMA levels (Figure 3H, right vs left panel).

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PMC11194678

Left: Representative images showing the distribution of TFEB in COS7 cells expressing PEGFP-C3, GFP-STAU1 WT, 5KE, or HKΔRBD4, as detected by immunoflurescence using TFEB antibody.

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PMC11317131

The mutagenesis plasmid (MP6 – Addgene #69669) provides increased mutagenesis rates by expressing proteins involved in mismatch repair (ugi and SeqA), DNA base excision (dam and cda1), DNA base selection (emrR), and proofreading (dnaQ926) under the control of the arabinose inducible pBAD system (40).

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PMC11267036

Therefore, this study explored the effects of DHM on MM and related mechanisms.

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PMC11257988

Nevertheless, KS-58 is an attractive lead molecule for developing new cancer drugs that target KRASG12D .

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PMC9014716

Moreover, there was a mild down-regulation in the relationship between miR-224-5 and ABCB1 mRNA, even though miR-224-5p can directly target ABCB1.

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PMC7723249

In the present study, we have established a more relevant in vitro model system based on human Caco-2 cells.

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PMC11758416

For example, if the lowest count of T cells recovered per condition is 9E4 T cells, then the number of T cells per well should be 4.5E4 T cells each in duplicate (to allow for a technical replicate).

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PMC11656657

p < 0.05, **p < 0.01, ***p < 0.001 In summary, our findings demonstrate that tumor-derived G-CSF is primarily responsible for the robust expansion of both monocytic and PMN-MDSCs in the xenograft OS NSG mouse model, highlighting the significant indirect immunomodulatory role of G-CSF in the sarcoma microenvironment.

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PMC9504875

V proteins of paramyxoviruses, including human parainfluenza virus type 2 (hPIV-2), PIV-5, and mumps virus, bind to MDA5 and LGP2 to suppress the production of type I IFN .

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PMC7823217

Encapsulation of stroma cells within 3D constructs mimic accurately tumor microenvironment as these cells secrete growth factors and ECM components needed for the tumor growth and migration potential.

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PMC8409415

The A2780 mock cells expressed progressively higher CD70 mRNA expression at 1 h (1.63, P = .04) and 2 h (2.99, P < .01) of treatment compared to the corresponding untreated cells.

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PMC10719213

Each biological replicate was maintained in either duplicate or triplicate for the duration of each experiment.

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PMC11661040

Compared to decades ago, the 5-year survival rate for patients with osteosarcoma after standard treatment (including extensive surgical resection, neoadjuvant chemotherapy, and adjuvant chemotherapy) has increased from less than 20% to about 65%(Berner et al. 2015).

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PMC11306331

We brought candidate solubilizing proteins to 3xFUS droplets using the blue-light sensitive dimerization pair, iLID/SspB. Solubilizing domain schematic shows MBP (PDB structure 1FQC).

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PMC7053076

The determination of anti-proliferative activity of U-332 and BGD was performed by the MTT assay, according to the Mosmann method, as described elsewhere .

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PMC9927933

We next examined whether UBE2C is under Kras regulation, and found that indeed ectopic overexpression of Kras significantly increased UBE2C at both the mRNA and protein levels without affecting UBE2S levels (Figure 2A and Supplemental Figure 2A).

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PMC11687663

It offers statistics on the molecule’s accessible surface area based on the quantity and variety of atoms it contains.

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PMC11760643

CDC of RPMI 8226 and J774 cells or freshly isolated PBMCs was performed using a variation of the method above.

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PMC11806182

C Leave-one-out sensitivity analysis for PCOS.

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PMC11392912

Further, we conducted in vivo studies using collagen-induced arthritic (CIA) rat models, and validated its therapeutic potential.

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PMC11380454

Finally, we performed preclinical experiments with either SAS or AS101 to explore their effects on B16/F10 melanoma-bearing mice either alone or in combination with anti-PD-1.

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PMC11244823

Serum No. 62 with no apparent antibodies against EHV-1 and EHV-4 was important to determine the negative cut-off in our newly developed LIPS assays.

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PMC11674891

Notably, genes promoting metastasis in various cancer types were significantly enriched in the GRPR-overexpressing cells (FDR < 0.25, Figure 4a).

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PMC11612794

As these two Mis12C-binding regions of CENP-T seem important for the CENP-T-Mis12C interaction, we further analyzed the molecular details of the CENP-T-Mis12C interaction and its significance in CENP-C DT40 cells.

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PMC8526701

C GIST-T1 cells were treated with GSK602 combined with imatinib at indicated concentration for 48 h. Cell viability was analyzed by MTT.

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PMC11496491

Fig. 6GO directed acyclic graph analysis results in terms of cell components.

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PMC11615101

Densitometric analysis of WB after normalization to GAPDH showed increased levels of STX3 (Figure 5B), STX4 (Figure 5C), TLR-4 (Figure 5D), and TLR-2 (Figure 5E).

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PMC11391695

Prior to delving deeper into the intracellular mechanism of ACYP2 in HCC, we established that ACYP2 exhibits a dual localization pattern, occurring simultaneously in the nucleus and cytoplasm.

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PMC10900886

Prevention of virus spread to and amplification in lymphoid tissues can therefore prevent the development of a subsequent viremia and severe extra-respiratory complications caused by EV-D68.

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PMC8557138

For example, during the process of fabrication, micro-molds, sacrificial materials, liquid templates provide support to geometries inside hydrogel materials (McNulty et al. 2019).

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PMC11487720

Finally, by time-lapse holography, we have demonstrated for the first time that there is an increased thickness or height in dividing or apoptotic cells.

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