OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11506827	The combination treatment significantly increased the apoptotic cell population compared to that in the controls in both cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "treatment", ...
PMC11591052	Importantly, the 20E-mediated augmentation of the studied enzymes and their transcriptional regulators was also confirmed at the protein level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "the", ...
PMC11470999	First, melanoma is characterized by numerous mutations, such as BRAF mutations, but the relationship between PF's activity and these mutations was not explored in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267830	c Comparison of fluorescence values between the two groups of mice, which served as an indicator of the extent of leukemia burden in the mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC2614415	VE-465 and paclitaxel are both drugs that function by targeting mitotic cells, but induce apoptosis by different mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "VE-465", "and", "paclitaxel", "ar...
PMC9429973	Eight patients had λ AL-type and three κ AL-type.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "patients", "had", "λ", "AL-type", "and", "three", "κ", "AL-type", "." ] } ]
PMC9429973	Responses in EMD were common.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Responses", "in", "EMD", "were", "common", "." ] } ]
PMC11792740	These findings highlight the potential of modulating cytokine signaling pathways to overcome T-cell exhaustion and improve cancer immunotherapy outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "highlight", ...
PMC11683130	Many members of this family can inhibit the activity of serine proteases such as chymotrypsin, so they are named serine protease inhibitors (Serpins) (3, 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11695623	In oral and lung squamous cell carcinomas, the mRNA level of DCUN1D5 corresponds to the protein level, and its overexpression is associated with reduced disease-specific survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704135	Compound 11 did not show any antimicrobial activity against any of the tested microorganisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "11", "did", "not", "show", "any", "antimicrobial", "...
PMC6114978	Western blot demonstrating a loss of expression of Hippo kinases relative to GCT (giant cell tumor) cell line. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", ...
PMC8633974	Co-transduction of TatD/TatE at MOIs of 10 and 1 significantly reduced the release of HIV-1 into culture supernatants by 80% and 94%, respectively (Figures 3b-c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519583	These findings prompted us to explore the role of Ror2 in regulating MP function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "prompted", "us", "to", "explore", "the", "r...
PMC11122631	For the predicted oral bioavailability, the colored zone in Figure S2 could be the suitable physicochemical space of the ideal compound, and six red spots showed the predicted values for the six properties of the test compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	Sagittal cryostat sections (8 μm) were processed for immunofluorescence using β-galactosidase and adrenocorticotropin hormone (ACTH) antibodies followed by Alexa Fluor-488 and Alexa Fluor-546.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11357960	It had been shown that up-regulation of certain SUMO machinery components correlated with the resistance in lung cancer (36).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "had", "been...
PMC9429973	By integrating BLUEPRINT epigenomic data with DNA breakpoint detection, we observed a broad H3K4me3 domain (BD) within the IGH locus of healthy B-cells that was absent in samples with IGH-CCND1 translocations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7154001	Moreover, the metabolites can be both active and toxic metabolites, and some metabolites are inactive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "metabolites", "can", ...
PMC11706776	Clones size is also significantly smaller for all three shRNA samples, compared to control cells (shRNA CT, Fig. 4B, left and right panels).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519567	Washed four times with 500 µl wash buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Washed", "four", "times", "with", "500", "µl", "wash", "buffer", "." ] } ]
PMC11354225	Meanwhile, there was a decrease in expression of the ferrochelatase enzyme transcript (FECH), which is responsible for heme group formation, due to the addition of an iron molecule to the PpIX ring (Figure 8B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11047729	Clinical trials and treatment focus on fatty acid properties, which are not connected to telomerase activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "trials", "and", "treatment", "focus",...
PMC10197932	OCI-AML-3 cell line was more sensitive to all treatments and showed a necrotic effect to a very high extent compared to the untreated (UT) controls and any intact cells were visible.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10482220	Thus, domain A could be recruited to SGs by dimerizing with the endogenous G3BP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "domain", "A", "could", "be", "recruited", ...
PMC9429973	Blood donations are collected in 6 units, n=8136 by fixed teams and n=2839 by mobile fixed units.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blood", "donations", "are", "collected", ...
PMC10040136	This result suggested that TGF-β2 could promote GIST growth by activating the PI3K-AKT signaling pathway, a signal downstream of KIT/PDGFRA, thereby circumventing the direct inhibition of KIT/PDGFRA activity by targeted therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222635	The morphology of the HeLa cells was observed using a fluorescence microscope (BX51, Olympus Optical Co. Ltd.).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "morphology", ...
PMC9429973	On average, 5.36 CNAs were observed per patient with a mean of 2.45 subchromosomal alterations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "average", ",", "5.36", "CNAs", "were", "ob...
PMC7185206	Stomach adenocarcinoma is one of the only two malignancies for which our analysis found an association between lower PD-L1 protein-to-mRNA ratios and improved outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11590870	Samples were read at an absorbance of 490 nm by a microplate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "were", "read", "at", "an", "absorbance", "of", "490", "nm"...
PMC11438317	The following day cells were stimulated with antibodies targeting CD3 and CD28 receptors for 6 h. The cells were then lysed, and the lysates were clarified by centrifugation at 16,000 g for 10 min before being used to measure luciferase activity with the Dual Luciferase system (Promega), according to the manufacturer's...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To study the rate and features of NK cell reconstitution after haplo-HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "study", "the", "rate", "and", "features", ...
PMC11747949	7‐AAD stain (#00‐6993‐50 eBioscience) was used to discern live cells from dead.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7‐AAD", "stain", "(", "#", "00‐6993‐50", "eBioscience", ")"...
PMC7840816	As shown in Figure 5A and B, TPC-1 and BCPAP cells transfected with siRNA-SOX9 displayed more cobblestone-like cell morphology and cluster formation when compared with siRNA-scramble-transfected cells, which exhibited a more mesenchymal phenotype with elongated shape.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11441402	Electrostatically bound SRB is then solubilized by a weak base such as Tris and absorbance is measured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electrostatically", "bound", "SRB", "is", "then",...
PMC11798926	In a separate study using hippocampal slice preparations, it was demonstrated that while SynDIG1 did not influence AMPAR biophysical properties, it nonetheless increases both AMPAR and NMDA receptor (NMDAR) content and functional excitatory synapse number when overexpressed (Lovero et al., 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6442998	Confocal microscopy.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Confocal", "microscopy", "." ] } ]
PMC11742670	4 presents the discussion of obtained results, and Sect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4", "presents", "the", "discussion", "of", "obtained", "results", ",", "and", "Sect", "." ...
PMC11684269	The hypoxic state of AKI enhances T cell glycolysis, leading to increased proliferation, which can be reversed by glutamine inhibitors (126).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11720808	P < 0.01 compared with the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.01", "compared", "with", "the", "control", "group", "." ] } ]
PMC10545062	We observed in this model that animals will continue to augment these metrics even when they are clearly euvolemic or hypervolemic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", ...
PMC11532793	We first explored the differences between the RTA-dispersion estimates obtained with either Gibbs or bootstrap sampling from Salmon for the lung adenocarcinoma cell line data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", ...
PMC9429973	After a median follow-up of 3 y (IR 1,6-6,2) from diagnosis, pts had relapsed at least one time (60,6%) and more than 3 times (11,5%), and 25 had died (40,9%), 16 of them due to infections (14 bacteremia, 2 COVID), 5 cardiorespiratory arrest and 3 due to progression. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	The GTEx (https://gtexportal.org/home/) and the Cancer Cell Line Encyclopedia (CCLE, https://sites.broadinstitute.org/ccle/) were used to compare KCNN1 expression levels in healthy tissues (GTEx version 8) and tumorous cell lines (CCLE - DepMap 22Q4), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9599726	These data suggest that VP largely, albeit not exclusively, induces cell death, whereas CA3 seems to exert its cytotoxicity entirely through ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11763111	This elevated IL-10 level likely contributes to the superior antitumor activity observed in 4KO-LLT1 CAR-T cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "elevated", "IL-10", "level", "likely", "contri...
PMC11790971	The feature values of the top 6 features are overlaid onto the t-SNE plots in (d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "feature", "values", "of", "the"...
PMC10523483	Consistent with in vivo results, GCLC levels were significantly down-regulated in H1.2 knockout A549 and A427 cells, accompanied with downregulation of GSH (Fig. 3 D–F and SI Appendix, Fig. S6 A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC4695073	b. CCRT, including concurrent chemoradiotherapy only and induction chemotherapy plus concurrent chemoradiotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b.", "CCRT", ",", "including", "concurrent", "chemoradiotherapy", "only", "...
PMC9960565	Cisplatin (cis-diamminedichloroplatinum(II)) is a potent chemotherapeutic agent commonly used to treat cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cisplatin", "(", "cis-diamminedichloroplatinum(II", ")", ")", "is...
PMC10092581	These complexes intrinsically possess an intriguing anticancer potential as they are holding biologically active ligands, i. e. selenoureas, which have been reported to exhibit a prominent anticancer effect.[ , , ]	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705547	Furthermore, FASN inhibitors can reverse the immunosuppression in the tumor microenvironment by upregulating cytotoxicity markers in NK cells and CD8+ T lymphocytes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11758416	Make a staining master-mix solution of 5 μL Annexin V, 5 μL 7-AAD and 90 μL Annexin V Binding buffer for each well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6684588	Weights of ACE-083-injected, vehicle-injected, and uninjected (contralateral) TA muscles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Weights", "of", "ACE-083-injected", ",", "vehicle-injected", ",", "and", "u...
PMC9429973	Methods: In this study patient were enrolled with confirmed diagnosis of Severe aplastic anemia who are not having full matched donor [10/10 HLA] or not fit for transplant but eligible for immunosuppressive therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704135	Subsequently, the clinical strains were expeditiously transported to the Microbiology Unit, Faculty of Science, Tanta University, for conducting in vitro assessments of the antimicrobial activity of synthesized pyrimidine derivatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11314247	Based on the above, our work group designed the compound N-(2-hydroxyphenyl)-2-propipylpentanamide (HO-AAVPA) in silico, derived from valproic acid (VPA), and subjected it to chemical synthesis and biological evaluation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674146	For colony formation assay, following the transfection, BJAB and RA 1 cells were grown in a 6-well plate at 1 × 10 cells/well and cultured at 37 °C for 14 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9429973	The Benjamini and Hochberg method was used to control the false discovery rate in multiple comparisons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Benjamini", "and", "Hochberg", "method", "was",...
PMC11049548	In the future it will certainly be interesting to explore the possibility of establishing primary ovarian cancer cells in human-like media; the use of these media both for primary and established ovarian cancer cells could open up scenarios partly masked in current culture media.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9822769	Since the cellular accumulation of 2 was energy-dependent, endocytosis (i.e., engulfment of the plasma membrane to trap extracellular substances in the vesicles) was first considered, although 2 is a low Mr molecule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To access the early mortality rate in older AML patients in two teaching hospitals in Brazil and describe the risk factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ...
PMC9429973	Therapies including hematopoietic stem cell transplant and immunosuppression are effective but entail costs and risks, and are not effective or possible in all patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11394227	Conversely, intracellular retention of TNFR/Fc protein was observed in other recombinant CHO cells, and PDI overexpression did not impact the productivity of thrombopoietin-secreting CHO cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLin...
PMC11759543	∗∗∗ and ###p < 0.001, ∗∗p < 0.01.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗∗∗", "and", "#", "#", "#", "p", "<", "0.001", ",", "∗∗p", "<", ...
PMC11489351	These results demonstrate that 24-h treatment with pH manipulation cell culture conditions does not significantly alter viability or colony formation of human epithelial MCF10A cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ],...
PMC9429973	Its clinical activity has been tested in r/r paediatric and adult B-ALL (Ghorashian S et al., Nat Med 2019; Roddie C et al., JCO 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Bioluminescence imaging (BLI) was performed using an IVIS Lumina Series III Imaging System.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bioluminescence", "imaging", "(", "BLI", ")", "was", "perfo...
PMC11488203	Accordingly, these miRs in taxol-loaded EVs/exosomes can enhance therapeutic effects by ameliorating entry into cancer cells and targeting functionalities in the primary tumor and in their metastatic progenies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727062	It also decreases the activities of MMP-2 and MMP-9 enzymes, thereby reducing the invasion and migration of melanoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also", "decreases", ...
PMC10958426	A SNV with significantly different alternative cell ratio between tumor subclones (Wilcoxon test) will be regarded as tumor subclone specific SNV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC11637276	To corroborate these results, highly invasive MDA-MB-231 and A2780-Rab25 cells were seeded on labelled CDM and treated with 10 μM and 50 μM of p38α/β inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11799620	The standard of this test is butylated hydroxytoluene BHT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "standard", "of", "this", "test", "is", "butylated", "hydroxytoluene", "BHT", "." ] } ]
PMC10798140	First, HepG2 cells were seeded into a six-well tissue culture plate (SPL, Gyeonggi-do, Korea) at a density of 2 × 10 cells per well.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Monoclonal gammopathy of undetermined significance is the most common plasma cell disorder, occurring in 3% of the population older than 50 years and is typically detected as an incidental finding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721295	Stop reagent was then added directly to the TSA solution and left for 5 minutes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stop", "reagent", "was", "then", "added", "directly", "to",...
PMC11078693	CRITICAL: Assure that the coated and labeled side of the cover glass is facing up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CRITICAL", ":", "Assure", "that", "the", "coated", ...
PMC9429973	Maximum reduction in serum tryptase on treatment was defined during each LOT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Maximum", "reduction", "in", "serum", "tryptase", "on", "treatment", "was", "def...
PMC11401350	G Three days post-transduction T cells were surface stained for CD8 and hCD34 followed by staining for CD69.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "Three", "days", "post-transduction", ...
PMC11684821	We also compared our TCRs (MC.7.G5, MC.27.759S, K8T-1, and K8T-2) to non-MAIT MR1-restricted TCRs from other studies (DGB129, TC5A87, and ACA14) that had been reported to only recognize cells overexpressing MR1 and exhibit no dependency on the K43 residue of MR1 for activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730305	Therefore, there is an urgent need to develop new drugs to combat this disease more effectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "there", "is", "an", "urge...
PMC11806182	Additionally, CD4.T.cells.1, annotated as another exhausted T cell subtype, was up-regulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "CD4.T.cells.1", ",", "annotated", "as", "another"...
PMC11727145	Keratinocyte proliferation medium, pioneered by Rheinwald and Green in the 1970s , allows the in vitro culture and expansion of keratinocytes on a 3T3 fetal mouse fibroblast feeder layer, which is also employed in the context of DED to nourish the seeded keratinocytes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC8633974	LNPs loaded with CleanCap FLuc mRNA, and Dasher GFP mRNA showed high encapsulation efficiency of 94.4% and 83.8% quantified by the RiboGreen RNA assay kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10578720	The statistical graph is presented in Figure 7B (right).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statistical", "graph", "is", "presented", "in", "Figure", "7B", "(", "right", ...
PMC10669128	This was further supported by Perez’s team, who demonstrated the potential therapeutic strategies of doxorubicin and olaparib against sarcomas in UPS PDXs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8336407	The percentage of arbutin recovered was determined by spiking a sample containing 7573 mg/L arbutin with an arbutin standard solution (2500 mg/L) to yield solutions with final concentrations of 7065, 6304, and 5036 mg/L. HPLC for standard arbutin (2500 mg/L) was performed using a Eurospher C-18 column (4.6 × 250 mm), m...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700165	Importins also have a crucial role in nuclear translocation of proteins that do not contain a bona fide nuclear localization signal (NLS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9844987	prQTLs, dprQTLs, and frQTLs were mapped using the MatrixEQTL R package (version 2.3) (Shabalin, 2012).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "prQTLs", ","...
PMC9027909	It was documented that Blastocystis sp., is not only able to dysregulate immune responses during colonization in the intestine , but also affects the permeability of the gut , both using its proteases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	H2O was measured with liquid scintillation counting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H2O", "was", "measured", "with", "liquid", "scintillation", "counting", "." ] } ]
PMC4005030	Protocatechuic acid PCA is considered as an active component of some traditional Chinese herbal medicines such as Cibotium barometz (L.) J.Sm, Stenoloma chusanum (L.) Ching, Ilex chinensis Sims (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540611	The prospect of creating drugs based on RNA interference implies the use of delivery systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prospect", "of", "creating", "drugs", "based", "on",...
PMC7039683	All candidate enhancer elements described were cloned using zebrafish or human genomic DNA, and were harvested from either zebrafish embryos or a human immortalized oral keratinocyte cell line (GMSM-K; Gilchrist et al., 2000).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750161	Oligonucleotides were synthesized, and mutated DNAs was sequenced by Genotech (Daejeon, Korea).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oligonucleotides", "were", "synthesized", ",", "and", ...
PMC9429973	Image: Summary/Conclusion: With the PET/TC adapted treatment after 3 cycles of ABVD in 59 patients > 60 years old, 81% of patients achieved negative PET and therefore received no further treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794588	Its ability to induce oxidative stress makes it effective in liver cancer cells, corroborating its anticancer action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "ability", "to", "induce", "oxid...
PMC9429973	Though not statistically significant, analyses suggest that among patients with CLL and T2D, BCR treatment might be superior to FCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Though", "no...
PMC11761919	Based on the amount of sodium alginate used for encapsulation and encapsulation efficiency, it was calculated that 0.1 g of microspheres was equivalent to 1.0 × 10 colony-forming unit (CFU).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11506827

The combination treatment significantly increased the apoptotic cell population compared to that in the controls in both cell lines.

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PMC11591052

Importantly, the 20E-mediated augmentation of the studied enzymes and their transcriptional regulators was also confirmed at the protein level.

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PMC11470999

First, melanoma is characterized by numerous mutations, such as BRAF mutations, but the relationship between PF's activity and these mutations was not explored in this study.

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PMC11267830

c Comparison of fluorescence values between the two groups of mice, which served as an indicator of the extent of leukemia burden in the mice.

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PMC2614415

VE-465 and paclitaxel are both drugs that function by targeting mitotic cells, but induce apoptosis by different mechanisms.

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PMC9429973

Eight patients had λ AL-type and three κ AL-type.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "patients", "had", "λ", "AL-type", "and", "three", "κ", "AL-type", "." ] } ]

PMC9429973

Responses in EMD were common.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Responses", "in", "EMD", "were", "common", "." ] } ]

PMC11792740

These findings highlight the potential of modulating cytokine signaling pathways to overcome T-cell exhaustion and improve cancer immunotherapy outcomes.

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PMC11683130

Many members of this family can inhibit the activity of serine proteases such as chymotrypsin, so they are named serine protease inhibitors (Serpins) (3, 4).

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PMC11695623

In oral and lung squamous cell carcinomas, the mRNA level of DCUN1D5 corresponds to the protein level, and its overexpression is associated with reduced disease-specific survival.

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PMC11704135

Compound 11 did not show any antimicrobial activity against any of the tested microorganisms.

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PMC6114978

Western blot demonstrating a loss of expression of Hippo kinases relative to GCT (giant cell tumor) cell line. (

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PMC8633974

Co-transduction of TatD/TatE at MOIs of 10 and 1 significantly reduced the release of HIV-1 into culture supernatants by 80% and 94%, respectively (Figures 3b-c).

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PMC11519583

These findings prompted us to explore the role of Ror2 in regulating MP function.

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PMC11122631

For the predicted oral bioavailability, the colored zone in Figure S2 could be the suitable physicochemical space of the ideal compound, and six red spots showed the predicted values for the six properties of the test compound.

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PMC11335267

Sagittal cryostat sections (8 μm) were processed for immunofluorescence using β-galactosidase and adrenocorticotropin hormone (ACTH) antibodies followed by Alexa Fluor-488 and Alexa Fluor-546.

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PMC11357960

It had been shown that up-regulation of certain SUMO machinery components correlated with the resistance in lung cancer (36).

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PMC9429973

By integrating BLUEPRINT epigenomic data with DNA breakpoint detection, we observed a broad H3K4me3 domain (BD) within the IGH locus of healthy B-cells that was absent in samples with IGH-CCND1 translocations.

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PMC7154001

Moreover, the metabolites can be both active and toxic metabolites, and some metabolites are inactive.

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PMC11706776

Clones size is also significantly smaller for all three shRNA samples, compared to control cells (shRNA CT, Fig. 4B, left and right panels).

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PMC11519567

Washed four times with 500 µl wash buffer.

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PMC11354225

Meanwhile, there was a decrease in expression of the ferrochelatase enzyme transcript (FECH), which is responsible for heme group formation, due to the addition of an iron molecule to the PpIX ring (Figure 8B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11047729

Clinical trials and treatment focus on fatty acid properties, which are not connected to telomerase activity.

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PMC10197932

OCI-AML-3 cell line was more sensitive to all treatments and showed a necrotic effect to a very high extent compared to the untreated (UT) controls and any intact cells were visible.

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PMC10482220

Thus, domain A could be recruited to SGs by dimerizing with the endogenous G3BP.

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PMC9429973

Blood donations are collected in 6 units, n=8136 by fixed teams and n=2839 by mobile fixed units.

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PMC10040136

This result suggested that TGF-β2 could promote GIST growth by activating the PI3K-AKT signaling pathway, a signal downstream of KIT/PDGFRA, thereby circumventing the direct inhibition of KIT/PDGFRA activity by targeted therapy.

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PMC6222635

The morphology of the HeLa cells was observed using a fluorescence microscope (BX51, Olympus Optical Co. Ltd.).

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PMC9429973

On average, 5.36 CNAs were observed per patient with a mean of 2.45 subchromosomal alterations.

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PMC7185206

Stomach adenocarcinoma is one of the only two malignancies for which our analysis found an association between lower PD-L1 protein-to-mRNA ratios and improved outcomes.

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PMC11590870

Samples were read at an absorbance of 490 nm by a microplate reader.

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PMC11438317

The following day cells were stimulated with antibodies targeting CD3 and CD28 receptors for 6 h. The cells were then lysed, and the lysates were clarified by centrifugation at 16,000 g for 10 min before being used to measure luciferase activity with the Dual Luciferase system (Promega), according to the manufacturer's...

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PMC9429973

Aims: To study the rate and features of NK cell reconstitution after haplo-HSCT.

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PMC11747949

7‐AAD stain (#00‐6993‐50 eBioscience) was used to discern live cells from dead.

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PMC7840816

As shown in Figure 5A and B, TPC-1 and BCPAP cells transfected with siRNA-SOX9 displayed more cobblestone-like cell morphology and cluster formation when compared with siRNA-scramble-transfected cells, which exhibited a more mesenchymal phenotype with elongated shape.

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PMC11441402

Electrostatically bound SRB is then solubilized by a weak base such as Tris and absorbance is measured.

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PMC11798926

In a separate study using hippocampal slice preparations, it was demonstrated that while SynDIG1 did not influence AMPAR biophysical properties, it nonetheless increases both AMPAR and NMDA receptor (NMDAR) content and functional excitatory synapse number when overexpressed (Lovero et al., 2013).

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PMC6442998

Confocal microscopy.

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PMC11742670

4 presents the discussion of obtained results, and Sect.

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PMC11684269

The hypoxic state of AKI enhances T cell glycolysis, leading to increased proliferation, which can be reversed by glutamine inhibitors (126).

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PMC11720808

P < 0.01 compared with the control group.

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PMC10545062

We observed in this model that animals will continue to augment these metrics even when they are clearly euvolemic or hypervolemic.

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PMC11532793

We first explored the differences between the RTA-dispersion estimates obtained with either Gibbs or bootstrap sampling from Salmon for the lung adenocarcinoma cell line data.

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PMC9429973

After a median follow-up of 3 y (IR 1,6-6,2) from diagnosis, pts had relapsed at least one time (60,6%) and more than 3 times (11,5%), and 25 had died (40,9%), 16 of them due to infections (14 bacteremia, 2 COVID), 5 cardiorespiratory arrest and 3 due to progression. (

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PMC11706776

The GTEx (https://gtexportal.org/home/) and the Cancer Cell Line Encyclopedia (CCLE, https://sites.broadinstitute.org/ccle/) were used to compare KCNN1 expression levels in healthy tissues (GTEx version 8) and tumorous cell lines (CCLE - DepMap 22Q4), respectively.

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PMC9599726

These data suggest that VP largely, albeit not exclusively, induces cell death, whereas CA3 seems to exert its cytotoxicity entirely through ferroptosis.

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PMC11763111

This elevated IL-10 level likely contributes to the superior antitumor activity observed in 4KO-LLT1 CAR-T cells .

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PMC11790971

The feature values of the top 6 features are overlaid onto the t-SNE plots in (d).

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PMC10523483

Consistent with in vivo results, GCLC levels were significantly down-regulated in H1.2 knockout A549 and A427 cells, accompanied with downregulation of GSH (Fig. 3 D–F and SI Appendix, Fig. S6 A and B).

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PMC4695073

b. CCRT, including concurrent chemoradiotherapy only and induction chemotherapy plus concurrent chemoradiotherapy.

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PMC9960565

Cisplatin (cis-diamminedichloroplatinum(II)) is a potent chemotherapeutic agent commonly used to treat cancer.

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PMC10092581

These complexes intrinsically possess an intriguing anticancer potential as they are holding biologically active ligands, i. e. selenoureas, which have been reported to exhibit a prominent anticancer effect.[ , , ]

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PMC11705547

Furthermore, FASN inhibitors can reverse the immunosuppression in the tumor microenvironment by upregulating cytotoxicity markers in NK cells and CD8+ T lymphocytes .

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PMC11758416

Make a staining master-mix solution of 5 μL Annexin V, 5 μL 7-AAD and 90 μL Annexin V Binding buffer for each well.

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PMC6684588

Weights of ACE-083-injected, vehicle-injected, and uninjected (contralateral) TA muscles.

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PMC9429973

Methods: In this study patient were enrolled with confirmed diagnosis of Severe aplastic anemia who are not having full matched donor [10/10 HLA] or not fit for transplant but eligible for immunosuppressive therapy.

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PMC11704135

Subsequently, the clinical strains were expeditiously transported to the Microbiology Unit, Faculty of Science, Tanta University, for conducting in vitro assessments of the antimicrobial activity of synthesized pyrimidine derivatives.

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PMC11314247

Based on the above, our work group designed the compound N-(2-hydroxyphenyl)-2-propipylpentanamide (HO-AAVPA) in silico, derived from valproic acid (VPA), and subjected it to chemical synthesis and biological evaluation .

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PMC11674146

For colony formation assay, following the transfection, BJAB and RA 1 cells were grown in a 6-well plate at 1 × 10 cells/well and cultured at 37 °C for 14 days.

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PMC9429973

The Benjamini and Hochberg method was used to control the false discovery rate in multiple comparisons.

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PMC11049548

In the future it will certainly be interesting to explore the possibility of establishing primary ovarian cancer cells in human-like media; the use of these media both for primary and established ovarian cancer cells could open up scenarios partly masked in current culture media.

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PMC9822769

Since the cellular accumulation of 2 was energy-dependent, endocytosis (i.e., engulfment of the plasma membrane to trap extracellular substances in the vesicles) was first considered, although 2 is a low Mr molecule.

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PMC9429973

Aims: To access the early mortality rate in older AML patients in two teaching hospitals in Brazil and describe the risk factors.

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PMC9429973

Therapies including hematopoietic stem cell transplant and immunosuppression are effective but entail costs and risks, and are not effective or possible in all patients.

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PMC11394227

Conversely, intracellular retention of TNFR/Fc protein was observed in other recombinant CHO cells, and PDI overexpression did not impact the productivity of thrombopoietin-secreting CHO cells .

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PMC11759543

∗∗∗ and ###p < 0.001, ∗∗p < 0.01.

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PMC11489351

These results demonstrate that 24-h treatment with pH manipulation cell culture conditions does not significantly alter viability or colony formation of human epithelial MCF10A cells.

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PMC9429973

Its clinical activity has been tested in r/r paediatric and adult B-ALL (Ghorashian S et al., Nat Med 2019; Roddie C et al., JCO 2021).

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PMC11365427

Bioluminescence imaging (BLI) was performed using an IVIS Lumina Series III Imaging System.

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PMC11488203

Accordingly, these miRs in taxol-loaded EVs/exosomes can enhance therapeutic effects by ameliorating entry into cancer cells and targeting functionalities in the primary tumor and in their metastatic progenies.

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PMC11727062

It also decreases the activities of MMP-2 and MMP-9 enzymes, thereby reducing the invasion and migration of melanoma cells.

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PMC10958426

A SNV with significantly different alternative cell ratio between tumor subclones (Wilcoxon test) will be regarded as tumor subclone specific SNV.

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PMC11637276

To corroborate these results, highly invasive MDA-MB-231 and A2780-Rab25 cells were seeded on labelled CDM and treated with 10 μM and 50 μM of p38α/β inhibitors.

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PMC11799620

The standard of this test is butylated hydroxytoluene BHT.

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PMC10798140

First, HepG2 cells were seeded into a six-well tissue culture plate (SPL, Gyeonggi-do, Korea) at a density of 2 × 10 cells per well.

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PMC9429973

Monoclonal gammopathy of undetermined significance is the most common plasma cell disorder, occurring in 3% of the population older than 50 years and is typically detected as an incidental finding.

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PMC11721295

Stop reagent was then added directly to the TSA solution and left for 5 minutes.

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PMC11078693

CRITICAL: Assure that the coated and labeled side of the cover glass is facing up.

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PMC9429973

Maximum reduction in serum tryptase on treatment was defined during each LOT.

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PMC11401350

G Three days post-transduction T cells were surface stained for CD8 and hCD34 followed by staining for CD69.

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PMC11684821

We also compared our TCRs (MC.7.G5, MC.27.759S, K8T-1, and K8T-2) to non-MAIT MR1-restricted TCRs from other studies (DGB129, TC5A87, and ACA14) that had been reported to only recognize cells overexpressing MR1 and exhibit no dependency on the K43 residue of MR1 for activation.

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PMC11730305

Therefore, there is an urgent need to develop new drugs to combat this disease more effectively.

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PMC11806182

Additionally, CD4.T.cells.1, annotated as another exhausted T cell subtype, was up-regulated.

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PMC11727145

Keratinocyte proliferation medium, pioneered by Rheinwald and Green in the 1970s , allows the in vitro culture and expansion of keratinocytes on a 3T3 fetal mouse fibroblast feeder layer, which is also employed in the context of DED to nourish the seeded keratinocytes .

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PMC8633974

LNPs loaded with CleanCap FLuc mRNA, and Dasher GFP mRNA showed high encapsulation efficiency of 94.4% and 83.8% quantified by the RiboGreen RNA assay kit.

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PMC10578720

The statistical graph is presented in Figure 7B (right).

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PMC10669128

This was further supported by Perez’s team, who demonstrated the potential therapeutic strategies of doxorubicin and olaparib against sarcomas in UPS PDXs.

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PMC8336407

The percentage of arbutin recovered was determined by spiking a sample containing 7573 mg/L arbutin with an arbutin standard solution (2500 mg/L) to yield solutions with final concentrations of 7065, 6304, and 5036 mg/L. HPLC for standard arbutin (2500 mg/L) was performed using a Eurospher C-18 column (4.6 × 250 mm), m...

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PMC11700165

Importins also have a crucial role in nuclear translocation of proteins that do not contain a bona fide nuclear localization signal (NLS).

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PMC9844987

prQTLs, dprQTLs, and frQTLs were mapped using the MatrixEQTL R package (version 2.3) (Shabalin, 2012).

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PMC9027909

It was documented that Blastocystis sp., is not only able to dysregulate immune responses during colonization in the intestine , but also affects the permeability of the gut , both using its proteases.

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PMC11371747

H2O was measured with liquid scintillation counting.

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PMC4005030

Protocatechuic acid PCA is considered as an active component of some traditional Chinese herbal medicines such as Cibotium barometz (L.) J.Sm, Stenoloma chusanum (L.) Ching, Ilex chinensis Sims (Table 1).

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PMC8540611

The prospect of creating drugs based on RNA interference implies the use of delivery systems.

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PMC7039683

All candidate enhancer elements described were cloned using zebrafish or human genomic DNA, and were harvested from either zebrafish embryos or a human immortalized oral keratinocyte cell line (GMSM-K; Gilchrist et al., 2000).

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PMC11750161

Oligonucleotides were synthesized, and mutated DNAs was sequenced by Genotech (Daejeon, Korea).

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PMC9429973

Image: Summary/Conclusion: With the PET/TC adapted treatment after 3 cycles of ABVD in 59 patients > 60 years old, 81% of patients achieved negative PET and therefore received no further treatment.

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PMC11794588

Its ability to induce oxidative stress makes it effective in liver cancer cells, corroborating its anticancer action.

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PMC9429973

Though not statistically significant, analyses suggest that among patients with CLL and T2D, BCR treatment might be superior to FCR.

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PMC11761919

Based on the amount of sodium alginate used for encapsulation and encapsulation efficiency, it was calculated that 0.1 g of microspheres was equivalent to 1.0 × 10 colony-forming unit (CFU).

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