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PMC11648299
This risk was consistent even when known risk modifiers for keratinocyte carcinoma were excluded in sensitivity analyses.
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PMC8097906
The most frequent cause of treatment failure is local failure.
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PMC11531735
We found statistically significant p values of 0.048 employing log-rank test with Bonferroni Correction for comparing ER121 high, ER121 Low, Herceptin and PBS groups.
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PMC11381192
One‐way analysis of variance (ANOVA) or Kruskal‐Wallis test was adopted for multiple group comparisons.
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PMC9429973
The mean age was 37.6 years in the good mobilizer group, while the mean age was 48.3 years in the poor mobilizer group.
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PMC5363531
Additionally, in REN cell line, sequential administration of the two agents was also investigated, as follows: cells were incubated with dasatinib for 72 hours, then dasatinib was washed out (rD) and PEM added for additional 72 hours at the increasing concentrations reported above (C); in another set of experiments, da...
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PMC11719944
It is important to note that correlation does not imply causality, but we believe that this approach could help identify prognostic or monitoring markers in these patients.
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PMC9429973
Overall, ZnO NPs may provide a new basis and idea in treating human acute myeloid leukemia in clinical practice.
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PMC11591052
Importantly, we observed a significant number of 20E-upregulated genes involved in protein translation, oxidative phosphorylation, different cellular biosynthetic processes, and stress response.
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PMC11656380
The peptides were cleaved from Wang PEG resin with a cleavage reagent consisting of trifluoroacetic acid (TFA)/triisopropylsilane/phenol/water (95/2/2/1).
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PMC11095939
Data are presented as means ± SEM.
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PMC9429973
Using age- and sex-adjusted multivariate models (Figure A), we found that AML survivors had a 2-fold higher risk of type 1/2 diabetes (DM 1/2), and a 3.5-fold increased risk of congestive heart failure (CHF) compared to the general population.
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PMC11078693
If blocking is required, the cell pellet can be re-suspended into the blocking buffer instead of PBS at step 5j.
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PMC10887351
Further studies need to be conducted in the future, as few in vivo or in vitro studies have correlated β3-ARs with ES.
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PMC11036064
We accessed the CCLE dataset to select a cell line with a high expression of RAF1 and a low expression of miR-34a for our in-vitro study.
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PMC9429973
The molecular basis of MPN was clarified with the discovery of driver mutations in JAK2, MPL and CALR genes, but the biological landscape is more complex than initially assumed.
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PMC11271800
Macrophages are one of the most abundant normal cells in the TME and are a “double-edged sword”, as they mediate cytotoxicity and phagocytosis, causing vascular damage and tumor cell necrosis.
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PMC11763764
The OVCAR8 cell line was identified as a high-grade serous ovarian cancer cell line with resistance to carboplatin .
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PMC11562028
In conclusion, a new high-efficiency and low-toxicity Re-CDs has been prepared via hydrothermal method.
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PMC7305184
The MTS Assay is a colorimetric method for determining the number of viable cells.
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PMC9429973
Our finding that the subjective feeling of fatigue is associated with a multidimensional lower performance in the ASCQ-Me, in addition to disease modifying therapy, psychological support will remain very important and should not be attributed to anaemia alone.
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PMC11291490
Data were presented as means ± s.d. (
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PMC11351758
To determine the toxicity of high glucose and mitochondrial calcium [Ca]m overload on 143B cells and NARP cybrids, both the 143B cells and NARP cybrids were prepared and incubated overnight with Dulbecco’s modified Eagle’s medium supplemented with either low glucose (25 mM) or high glucose (75 mM).
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PMC8557138
Semba et al., used dorsal air sac model to validate the anti-angiogenic activity of E7820 against subcutaneously grown human pancreatic cancer cell line KP-1 and AsPC-1, colorectal cancer cell lines WiDr, Colo320DM and LoVo, breast cancer cell line BT20, and Kidney cancer cell line RCC-1 (Semba et al. 2004).
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PMC11525028
Quantification of colony formation (right) (n = 3).(E) Migration and invasion of NAT10-KO 143B cells (left).
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PMC11412721
Survival curves of patients from dataset #GSE136337, for the 30% patients with the highest ACKR4 mRNA levels and the 30% patients with the lowest ACKR4 mRNA levels in malignant plasma cells, classified according to sex (n = cohort sizes).
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PMC9429973
We hypothesize that different oncogenes lead to the expression of different CDK6-dependent transcriptional programs and to different CDK6-containing protein complexes on DNA level.
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PMC9429973
Results: Complete response to cobimetinib was not achieved in any patient.
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PMC8701144
SIM images were acquired using 5 grid rotations for 22 Z planes with a Z spacing of 0.184 nm between planes.
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PMC11696576
H-L-Cys-OMe or HCl.
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PMC9681981
Lanes 1-3: Bacteria in contact with Caco-2 cells, and Lanes 4-6: Bacteria not in contact with Caco-2 cells Melting curves of RT-qPCR reactions are shown in Fig. 5.
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PMC9429973
Population pharmacokinetics provide a powerful tool to predict the time to clear HDMTX and adjust doses for subsequent courses.
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PMC11635087
Before the co-cultivation, 4.8 × 10 isolated chloroplasts were centrifuged at 2500 rpm for 5 minutes, and the supernatant was removed.
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PMC4277423
C. CCR5 gene disruption analysis in mock-transduced CEMss-CCR5 cells or CEMss-CCR5 cells transduced with a single lentiviral vector pRRL-CR2 sgRNA-Cas9/EGFP by T7EI assay.
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PMC11483468
One day after cell implantation, the mice were randomized into three groups (five mice per group) and then injected with PBS, 20 mg/kg T-GFP or TAT-LPTS39 via the tail vein.
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PMC9672323
However, TGF-β production was lower in the U-87 MG cell line treated with both concentrations of piroxicam, although not significant (Fig. 9b, p = 0.084).Figure 8The effect of drugs on the IFN-γ levels of T cells in PBMCs alone or in co-culture condition.
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PMC11464982
U: units (see Section 3.3.1).
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PMC11718109
Interestingly, appearance of these large vesicles has been observed in DA axonal boutons of the mouse nucleus accumbens, whose identity has yet to be characterized.
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PMC7053076
The aim of this study was to determine the level of NF-κB subunits in the resistant HL-60/5-FU cells and to evaluate the potential of U-332 to inhibit activation of NF-κB family members in this cell line.
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PMC11354225
Conversely, chelation of iron has been utilized to promote apoptosis in colon cancer cases, using desferrioxamine .
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PMC6889484
Interestingly, the higher frequency of hypermutation observed for the A33G(DK) proviral DNAs compared to the A3x3G(DK) vector suggested that the A33G-D128K fusion protein was expressed, incorporated into virions, and retained cytidine deaminase activity.
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PMC11483468
As an effective therapeutic method, peptide drugs are characterized by high activity, strong specificity, low toxicity, clear biological function and benefit for clinical application (27).
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PMC10852540
While protecting normal cells by eliminating ROS at low doses, at high doses it induces apoptosis and cytotoxicity in cancer cells30.
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PMC11365983
Embryos were harvested at E15.5 in ice-cold HBSS with calcium and magnesium.
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PMC9964654
On the other hand, their stability can be attained by the careful choice of appropriate inert ligands, such as polydentate ligands with sulphur, oxygen, or nitrogen as electron-donor atoms .
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PMC9429973
Globally, in the unsupervised hierarchical cluster analysis (HCA), patients were separated by lineage.
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PMC9429973
No acute severe bacterial infections were reported during the study.
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PMC11119602
Hence, TG2-S could directly or indirectly contribute to cisplatin detoxification, by facilitating the intracellular trafficking of autophagosomes and their fusion with endolysosomal vesicles by modulating the actin cytoskeleton dynamics (Figure 8, right panel).
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PMC11283030
As shown in Fig. 2b (Table S1), ACLY expression level was significantly higher in metastatic subgroup than the subgroup without metastasis (P < 0.001).
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PMC7348793
Due to historical remoteness, DNA samples from the donor animal used to derive the CV1 cell line were not available for our studies.
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PMC8806312
Figure 7.Evaluation of the proportions of TIICs based on CIBERSORT. (
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PMC11701801
Data are presented as the mean ± SEM.
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PMC11703896
However, the mechanism by which rapamycin maintains the haemostasis in cancer and neurodegenerative disease is unclear.
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PMC10178190
This, in turn, promoted MSC survival and IL-6 and IL-8 secretion, which affected cancer cells’ chemoresistance .
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PMC11026382
The entire DHFR coding region containing restriction sites (NotI and EcoNI) was amplified by PCR.
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PMC9596868
However, both quercetin and MST-312 exhibit pleiotropic effects on cell signalling and synergy in modulating those activities cannot be overruled.
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PMC11777207
The molecular interactions between PD-L1 and PD-1 visualized using the available crystal structures from Protein Data Bank (PDB) demonstrates partially overlapping binding sites between PD-L1 with PD-1 and its other binding partner CD80 (32, 33).
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PMC9812014
SIP-1 had no negative effects and did not interrupt cell cycle progression or induce apoptosis in Molt-4 and HeLa cell lines, according to MTT, flow cytometry, and a caspase-3 assay.
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PMC11655498
P, phosphorylation.
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PMC10998613
Scale bars, 10 μm.) (
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PMC10380508
Approximately 95% of RCC patients exhibit high expression levels of the PAX2 and PAX8 genes, and the expression of PAX genes has been associated with metastasis .
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PMC11650848
For the SNP pyroassay, a separate assay was designed using the same software.
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PMC10589262
To verify the significance of ATF6 as a therapeutic target in GISTs, the antitumor effects of PF, Ceapin-A7, and melatonin, which are reported ATF6 inhibitors, were investigated.
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PMC9895440
j CD25 geometric mean intensity of stimulated T cells with or without SNX9 KO.
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PMC8009078
The grid coordinate was assigned as 48.554, 60.627 and 44.601 along the x-, y- and z-axis, respectively.
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PMC11012012
The prognostic impact of SLAMF3/CD229 in CLL was evaluated in a proteomic study by Saberi Hosnijeh et al. (2020) .
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PMC9429973
W. Barcellini, R. F. Grace, H. Al-Samkari, A. Glenthøj, J. A. Rothman, M. Morado Arias, D. M. Layton, O. Andres, M. DiBacco, P. Hawkins, M. P. Judge, F. Tai, J. Morales-Arias, V. Beynon, E. J. van Beers Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Dana-Farber/Boston Children’s Cancer and Blo...
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PMC7351993
The primary difference between this real-time Raman image processor and our earlier image processor lies in their image construction architecture; the present processor is designed such that it constructs images simply by gathering 24-parallel four-color SRS image signals sent from many data acquisition nodes whereas t...
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PMC10079526
J MCODE was used to extract the most interconnected clusters from the STRING network analysis in I. Cluster 1 represents proteins involved in methylation.
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PMC10530622
Additional evidence came from whole exome sequencing research performed in a hyperoxaluric pedigree, in which the detected heterozygous p.R507W SLC26A6 missense mutation co-segregated with the calcium oxalate nephrolithiasis .
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PMC11564322
To date, it has been well evidenced that mTOR activates the PPARγ signaling pathway .
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PMC11723210
The blue curve represents the results from the BPR method, which accurately tracks the changes in dry mass.
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PMC10728200
The results are displayed as a ratio of oxidized/reduced C11-BODIPY.
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PMC7987994
We compared the toxic effect of the extracts on L929 murine fibroblast-derived cell line, which is recommended by ISO standard and on “osteoblast-like cells” U-2 OS.
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PMC5600151
The high level of control possible over their architecture makes them attractive as systems for drug and gene delivery applications.
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PMC11761919
In the present study, Fiber2 fusion protein was expressed on the surface of cell wall, which was detected by western blot and indirect immunofluorescence.
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PMC11803918
Meanwhile, our recent studies further revealed that exosomes derived from human γδ-T cells (γδ-T exosomes) can control EBV-associated tumors.
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PMC11224020
A good candidate for driving such a response was ARP2/3, as this complex has been shown to nucleate distinct types of actin structures in the perinuclear area of DCs undergoing nucleus deformation.
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PMC11763111
Statistical significance was determined by two-tailed unpaired Student's t-test. *
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PMC8998437
Consequently, in immunocompromised patients or during transient immunodeficiency, chemotactic migration of the CCR1-expressing BL cells into secondary organs could impact disease pathogenesis.
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PMC10170482
F-actin (green) was stained using the ActinGreen 488 ReadyProbes reagent.
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PMC11243198
For some C3H10T1/2 cell experiments, a 384-well colorimetric readout assay (pNPP substrate, 405 nm absorbance, clear plates) was used.
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PMC9429973
Treatment tolerability was reported by patients in FACT-Lym item GP5 (“I am bothered by side effects of treatment”).
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PMC10158546
We applied the spearman-karber transformation to the RT-QuIC data to obtain a single quantitative measurement of prion-seeding activity within each sample, expressed as log10(SD50) per gram of total protein.
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PMC11391695
Furthermore, it was observed that si-ACYP2 + si-KCNN4-treated SMMC-7721 and BEL-7404 cells exhibited increased expression levels of both ERK and p-ERK, whereas pcDNA-ACYP2-treated SK-Hep-1 cells displayed decreased expression levels (Fig. 3J and Fig. S4H).
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PMC11789597
However, its biological and clinical implications in MM are still not fully elucidated.
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PMC7759933
A decrease in cell proliferation in different 3D cell models overtime was reported in several studies with HepG2, using extra-cellular matrix-based hydrogel and spheroids prepared by the hanging drop method , and HepG2/C3A, culturing in rotating bioreactors .
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PMC7987994
Three replicates 1–3 were used.
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PMC9429973
Although we observed an expected reduction in the CD3+ cells after IST both in the HABMF and nonHABMF group, there was no significant difference in the TRB repertoire diversity in the HABMF patients between D0 and D120.
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PMC3888431
Functional annotations were assigned for 51,045 of the transcripts (77%), which correspond to 10,643 of the 17,598 clusters (60%).
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PMC5916734
Evaluation of the integrity of the open reading frame sequence in the target gene We demonstrated by PCR using genomic DNA and primers specific to the promoter and terminator regions of the employed expression vectors that the predominant PCR products have the correct size (Fig. 4A).
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PMC10329237
Thus, it possesses great potential as a new treatment for non-small cell lung cancer (NSCLC) cell lines (29).
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PMC11240448
To recapitulate better the existing experimental data on the activation of the MAPK/ERK pathway, a connection from EGFR to ERK was modelled in greater mechanistic detail.
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PMC11257988
Their experiments demonstrated that SOS1 deficiency specifically inhibits the rates of lung tumor cell proliferation (Ki67) and ERK activation (pERK), while also significantly affecting the pro-tumor activities of various cell subpopulations within the LUAD microenvironment .
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PMC11588008
Cell viability was detected by the CCK8 test.
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PMC11730320
The absence of pre-TCRα prompted in depth analyses of T cell subsets in our patient.
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PMC11599565
By the same token, glioblastoma multiforme cells can transdifferentiate into functional vascular endothelial cells in hypoxic conditions, which implies that cells derived from the ectoderm convert into cells derived from the mesoderm.
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PMC11794847
Regulatory T cells (Tregs), which function to suppress immune responses and maintain immune homeostasis, also exhibit unique metabolic characteristics .
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PMC9220170
Since SELENOM and SELENOT are residents of the ER, it was important to follow how the mRNA expression of other ER selenoproteins would change under the same conditions.
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PMC11361748
On the second day, samples were washed and incubated with fluorophore-conjugated secondary antibodies for 1 h at room temperature in dark.
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