OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11748335	Moreover, the proportions of OGs or TSGs in long LOCKs in each methylation domain were mostly similar to the background.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC11247842	We applied two meta-analysis methods to the clean summary statistics data, a fixed effect model for a meta-analysis using the software METAL and a trans-ethnic meta-regression approach implemented in the software MR-MEGA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	Fn/c for p65 was determined as above using a BioTek Cytation 5 Cell Imagining Mult-Mode reader and Gen5 Image Prime software, selecting for cells expressing MERS ORF4b or mutants in transfected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489175	The armamentarium of drugs available for ovarian carcinoma treatment is quite poor, although it has been recently enriched by the approval of inhibitors of Poly-ADP ribose polymerase (PARP) both for BRCA1 and BCRA2 mutant cancers as well as for the maintenance therapy of non-mutant platinum-sensitive recurrent ovarian ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8481254	Scale bars: 500 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "500", "μm", "." ] } ]
PMC9429973	Summary/Conclusion: We present a robust pre-clinical proof of concept of a potent allogeneic dual CAR T-cell product candidate, UCART20x22, with the potential to 1) overcome common mechanisms of resistance in B-NHL, 2) enable the development of allogeneic CART option for B-NHL patients, 3) reduce the time from treatmen...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	8/23 (35%) had complex cytogenetics, 6/23 (26%) had TP53 mutations, and 5/23 (22%) had therapy-related MDS/CMML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793	Moreover, evidence has accumulated that MNMs behave differently with these assays due to their unique physicochemical properties, leading to unexpected biological effects, interferences with assay readouts, and reactivity with assay components .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Statistical calculations were performed in the R. Results: The results indicate a high heterogeneity of indicators, while the levels of individual mRNAs did not correlate with each other, as well as with the level of leukocytosis or the proportion of blast cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640555	At the end of incubation with the primary antibodies, the sections were washed with PBS and incubated with a secondary antibody (Santa Cruz Biotechnology, Dallas, TX, USA) for 1 h at room temperature (RT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502443	Transfected cells underwent a serum-starve at 37°C for 30 min in 50 μL of serum-free media (DMEM +0.1% BSA) before stimulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540692	Briefly, the cells were treated with the analyzed compounds/mixes, in the concentrations allowing >70% of cell survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "t...
PMC11144382	In contrast, in experimental neurodegenerative disease and age-related cognitive dysfunction models, treatment with dietary supplements of alpha lipoic acid resulted in downregulation of VCAM1, reduced inflammatory cell infiltration into the CNS and improved memory.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765879	The observation of the cells throughout the incubation period revealed that at both concentrations, the extract had significantly decreased the number of colonies in both cell lines when compared with the control; in addition, upon visual observation, the sizes of the colonies formed in the treated groups were smaller ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10522430	This study delves into the influence of G. applanatum crude polysaccharide (GACP) extract on proinflammatory cytokines and its induction of apoptosis in HeLa cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC9250505	Information of primary/secondary antibodies were tabulated in Supplementary Table 9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Information", "of", "primary/secondary", "antibodies", "were", "tabulated", "in", "Supplementary", "Ta...
PMC11779605	Cell type is labeled above each plot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "type", "is", "labeled", "above", "each", "plot", "." ] } ]
PMC11594641	Rab27 was found to regulate the proliferation, migration, invasion, or clone formation of various types of cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rab27", "was", "f...
PMC7338939	It has also been determined that treatment of melanoma cells with Notch inhibitors with GSIs can result in tumor regression (18, 26, 27).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10873328	Furthermore, the protein level of TGFBI was strongly expressed in OC tissues using standard IHC labeling collected from HPA (Figs. 2j–m).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11774747	They observed cooperation between CD40L, OX40L and pp65 antigen presentation, significantly enhancing the activation and antitumor responses of the CAR-VSTs in vivo (n=8) in a murine model of xenogenic tumor, thanks to the induction of APC maturation upon antigen processing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545737	with S. flexneri being the first microorganism discovered to induce pyroptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "with", "S.", "flexneri", "being", "the", "first", "microorganism", "discovered", "to", ...
PMC11320084	a, b) Cell migration of LC cells with TNNT1 knockdown. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", ",", "b", ")", "Cell", "migration", "of", "LC", "cells", "w...
PMC6468656	We previously identified a peptide hormone, ghrelin, and investigated the function and mechanism of ghrelin in RCC metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "previously", "identifi...
PMC11684821	These differences may reflect divergences in TCR specificity or variation in accessory molecules on the T cell clones and/or target cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "differences", ...
PMC11590870	At the tested concentrations, MOP did not affect Caco-2 proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "At", "the", "tested", "concentrations", ",", "MOP", "did", "not", "affect", ...
PMC11655498	To successfully replicate and propagate within the infected cells, EBV has evolved various strategies to evade the host’s innate immune surveillance (Figure 2B and Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	day 1, prednisone 100 mg orally day 1-5) followed by additional 2 cycles of rituximab every 21 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "day", "1", ...
PMC11267036	Also, DHM inhibited MM tumor growth and EMT, and activated STAT1/RIG-I pathway in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "DHM", "inhibited", "MM", "tumor", "...
PMC11464982	Submitted by Shin Nihon Chemical Co. Ltd. Additional information.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Submitted", "by", "Shin", "Nihon", "Chemical", "Co.", "Ltd.", "Additional", "information", "." ] } ]
PMC9429973	Aims: To develop an approach for improved ex vivo HSC expansion using novel bone-lining reinvigorating Mesenchymal Stromal Cells (rMSC)-based culture system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...
PMC11377827	Protein G magnetic beads (25 μl) were added and incubated for a further 2 h at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "G", "m...
PMC11768281	In contrast, a modest humoral response but a strong cellular response can be induced by the majority of viral vector subunit malaria vaccines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10748106	Human papillomavirus (HPV) infection is the principal cause of cervical cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "papillomavirus", "(", "HPV", ")", "infection", "is", "the", ...
PMC9429973	Aims: Provide updated safety and efficacy data for pts with CML-CP with T315I treated with asciminib monotherapy 200 mg twice daily (BID) after added exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11695546	The use of coconut oil to avoid or manage Alzheimer's disease is not well-supported by scientific research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "coconut", "oil", ...
PMC11711663	This study addresses the limited noninvasive tools for Head and Neck Squamous Cell Carcinoma (HNSCC) progression-free survival (PFS) prediction by identifying Computed Tomography (CT)-based biomarkers for predicting prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531744	First, the heat-map of the 25 genes involved in the construction of the prognostic model in the different risk group was shown in Fig. 5A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8140214	Our results also showed that 72hr treatment of HepG2 cells with 50 mM D-glucose significantly increased the level of MDA to about 41%, and quercetin significantly decreased the MDA level in 50 mM D-glucose-treated cells (p<0.05) (Figure 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9739791	FMN was loaded into the Au nanoparticles modified by a C11 thiol linker with terminal triazacyclononane (TACN) moieties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FMN", "was", "loaded", ...
PMC11180402	K & L) Colonies of 5637 (SOX2) and 5637 (Vector) cells in soft agar with 20 µM ISO or 0.1% DMSO (K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC5600151	The formulation developed by Starpharma (Melbourne, Australia), named DEP docetaxel, presented improved tumor targeting and effectiveness against different solid tumors—including breast, ovarian, prostate, and lung—compared to Taxotere, the docetaxel formulation used in the conventional chemotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678130	This finding confirms the results of a previous study that illustrated the efficacy of QUE (130 µM) in improving the antiangiogenic properties of 5-FU (5 µM) in vitro on the HUVEC cell line, and in ovo on the CAM .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682172	The quantity and quality of the isolated RNA were assessed (2100 Bioanalyser, Agilent Technologies, Santa Clara, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quant...
PMC10926885	Numerous studies have shown that the degree of immune cell infiltration may be able to predict the prognosis of a tumour. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numerous", "...
PMC11741906	Remarkably, higher expression levels of hsa-miR-133b, hsa-miR-512, hsa-miR-200b, and hsa-miR451a were associated with poor overall survival of ovarian cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11381192	p < 0.01, ***p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.01", ",", "", "", "*", "p", "<", "0.001", "." ] } ]
PMC10577955	The angiogenic process is regulated at various levels, starting with factors within the tumor microenvironment, followed by the modifications in signaling pathways containing key regulatory molecules as vascular endothelial growth factor (VEGF) expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	Vehicle control.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Vehicle", "control", "." ] } ]
PMC11615828	COS7 cells co‐transfected with EMTB‐CFP‐FRB (blue) and indicated mNeon‐FKBP tagged vesicular markers (green) were treated with rapamycin (Rapa, 100 nM) for the inducible vesicle immobilization.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	LC-MS/MS-based circadian proteome analysis was performed as previous described with some modifications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LC-MS/MS-based", "circadian", "proteome", "analysis", "was", "performed", "as", "previ...
PMC11787355	Notably, depletion of PTPRZ1 results in significant impairment of glioma cell sphere formation in vitro and delays tumor growth in vivo, indicating a strong association of PTPRZ1 with glioma cell stemness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	By impeding the activation of KCNN4 and subsequent release of K, ACYP2 in HCC cells inhibits the ERK pathway and impedes the malignant progression of HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11269933	The Figure 3C demonstrated that the SASA values of the S11 phosphorylated system are lower than that of the wild-type system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Figure", "...
PMC11612794	Immunoprecipitation using anti-FLAG antibody in AID-based CENP-T conditional knockdown GFP-Dsn1/CENP-C cells expressing 3xFLAG-CENP-T, 3xFLAG-CENP-T, or 3xFLAG-CENP-T. Cells were cultured with IAA for 12 h and nocodazole was added for last 10 h before immunoprecipitation experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	3PTPRZ1 TCR-T product was persistent, TSCM-abundant, and efficient in target cell killing.a TCR expression on primary human T cells over 3-week period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11371747	The moderate protection by 5 µM l-LV (Table 5) indicates that at this concentration, passive diffusion may contribute to l-LV uptake.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	M. Nowicki, A. Wierzbowska, E. Stec-Martyna, D. Kulczycka-Wojdala, G. Nowicki, A. Szmigielska-Kapłon Department of Hematology, Copernicus Memorial Hospital in Lodz Comprehensive Cancer Center and Traumatology, Poland; Department of Hematology; Central Scientific Laboratory, Medical University of Lodz, Łódź, Poland; Geo...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Their median BCR-ABL gene expression before treatment was 79% (range = 0.63-380) that decreased to 3.65% (range = 0.05-20) and 0.750 % (range = 0.002-46) on 3 and 6 months post-treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	n = 7 donors of n = 2 experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "7", "donors", "of", "n", "=", "2", "experiments", "." ] } ]
PMC10529414	The trimmed reads were then aligned to the hg38 reference genome using BWA Aligner with the MEM algorithm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "trimmed", "reads", "were", "the...
PMC10047551	In NSCLC, EGFR and KRAS mutations regulate PD-L1 expression through different cell signal transduction pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "NSCLC", ",", "EGFR", "and", "KRAS", "mutat...
PMC11511922	All data represent one set of triplicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "represent", "one", "set", "of", "triplicates", "." ] } ]
PMC9429973	The patients with MPNs were diagnosed according to the latest WHO criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patients", "with", "MPNs", "were", "diagnosed", "according", "to", "the",...
PMC11766350	One such transgene is TNF-related apoptosis-inducing ligand (TRAIL), which induces cell death by binding to the DR4 (TRAIL-R1) or DR5 (TRAIL-R2) death receptors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055443	Anti-inflammatory cytokines like IL-10 suppress cAMP production and reduce chloride secretion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-inflammatory", "cytokines", "like", "IL-10", "suppress", "cAMP", "production", "and", ...
PMC11583690	MSN@DTX, BPMO@DTX, and free DTX particles were used to evaluate DTX release into PBS (pH 7.4) and CPB (pH 5.5), both containing 0.1 % (v/v) Tween 80 to enhance DTX's solubility .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11047729	A study on human leukemia cells THP-1 and H937 showed that cordycepin-induced apoptosis influences telomerase, causing its deactivation and the down-regulation of both hTERT and its transcription factors—c-Myc and Sp1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Thus, patients with both risk factors had 5-year FFP rates 73-75% and 5-year OS 81-83%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", ...
PMC11451940	4 μM (48 h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4", "μM", "(", "48", "h", ")", "." ] } ]
PMC11190238	But what has been of contention is whether these transcriptional repertoires are context specific that there might not be universal master transcription regulators particularly in scenarios with known diverse heterogeneity such as tissue fibrosis and cancer metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614415	Following VE-465 treatment, phoshpo-p53 levels are reduced at doses of 1 nM and higher, indicating an inhibition of Aurora-A activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", ...
PMC11653168	Total STAT3 and β-actin were used as loading controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "STAT3", "and", "β-actin", "were", "used", "as", "loading", "controls", "." ] } ]
PMC11621565	These changes indicated successful differentiation into dopaminergic-like neurons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "changes", "indicated", "successful", "differentiation", "into", "dopaminergic-like", "neurons", "." ] } ]
PMC11180402	K-L) The invasion abilities of 5637 (vector) and 5637 (miR-129 Inhibitor) cells, with or without ISO treatment, were assessed using the Transwell assay (K), and the relative invasion ability was plotted in (L). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11543885	The following day, pellet the beads on the magnetic rack and collect the supernatant (flow-through) for further analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "following", ...
PMC9118379	This yielded 1123 single amino acid variants for this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "yielded", "1123", "single", "amino", "acid", "variants", "for", "this", "study", "...
PMC11772449	Studies (Luo et al., 2016) have confirmed that in patients with high expression of ATG7, due to the activation of autophagy and the increase of intracellular autophagy level, these patients have a poor prognosis and resistance to Sora treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740573	Wells A3, D3 and G3 show positive controls and confirm no contamination occurred while preparing the plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wells", "A3", ",", "D3", "and", ...
PMC11549062	The plaques were categorized into stable and vulnerable types based on ultrasound and histopathological assessments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plaques", "were", "categorized", "into", "stable", "...
PMC11462929	We generated a genome‐wide copy number alteration map using a previously reported microarray dataset covering 710 K single‐nucleotide polymorphisms in 72 BCP‐ALL cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11486946	Ba/F3 cells (RIKEN BRC) and Ba/F3 cells expressing EGFR (a kind gift from Dr. Ryo Iwamoto and Dr. Eisuke Mekata, Osaka University) were cultured at 37 °C in RPMI medium supplemented with 10% FBS and 4 ng/mL mouse IL3 (091-03971, Fuji-Wako, Japan).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8567602	First, an assay of tumorigenesis initiated by TATCre limb injections at age 4 weeks compared three genotypes of mice that were all heterozygous for hSS2, and wild-type, heterozygous, or homozygous for Smarcb1 floxed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	Insertion of the sYFP after position M264 led to a construct which was expressed mainly at the membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Insertion", "of", "the", "sYFP", "afte...
PMC11767725	Specific ML approaches, such as supervised learning algorithms (e.g., random forests, support vector machines) or unsupervised clustering methods, were highlighted for their contributions to advancing precision dermatology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10135767	When compared to the control group, the knockdown of Kindlin-3 significantly lengthened the delay and peak times while weakening the peak intensity of calcium signaling in RPMI 8226 cells (Figure 6E–G), suggesting that the blockage of Kindlin-3 could disturb calcium bursting triggered by the interaction of integrin α4β...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655536	in (A).	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "in", "(", "A", ")", "." ] } ]
PMC10197932	As shown in Figure 3A and Figure 3B, 2T Jurkat cells are not able to proliferate as UT controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", ...
PMC11564322	3mRNA expression of NFKB2 and PPARγ genes in the leukemia cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3mRNA", "expression", "of", "NFKB2", "and", "PPARγ", "genes", "in", "the", ...
PMC11476264	The sonicated cell lysates were incubated with purified sFBXO11 or ZEB1-truncated proteins and Ni-NTA beads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sonicated", "cell", "lysates", "were", "incubated", ...
PMC11703992	PMA induced Jurkat activation, and a significant increase in DDIT4 expression.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PMA", "induced", "Jurkat", "activation", ",", "and", "a", "significant", ...
PMC10808409	The optimized values of the variables with the predicted and observed responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "optimized", "values", "of", "the", "variables", "with", "the", "predicted...
PMC10975211	This targeted delivery minimizes off-target effects and improves the therapeutic index of buforin-containing bioconjugates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "targeted", "delivery", "minimizes", "off-target", "effects", "...
PMC11638288	The research conducted by Chen et al. also demonstrates that in activated NK cells, overexpression of miR-544 suppresses the cytotoxicity against hepatocellular carcinoma cells by directly targeting and downregulating RUNX3, thereby inhibiting NCR1/NKp46 signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680049	The formation of primary callus tissue occurred over the entire surface of the shoot segment and also from the mesophyll of the leaf blade located near the central vein (Figure 3a,b and Figure 4a–c).When cultivating primary explants (shoot segments) horizontally in light, callus formation was inhibited, and only in rar...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6642070	Currently, the definition, epidemiology, diagnosis and management of SAMS are conflicting, which could be improved by further understanding of the pathophysiology of the symptoms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910	The sections were washed two times for five minutes each with PBST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sections", "were", "washed", "two", "times", "for", "five", "minutes", ...
PMC9250505	B Mice were treated daily with vehicle (V), 20 mg/kg NPB (N), 50 mg/kg Olaparib (O), or a combined NPB-Olaparib by i.p.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9559528	Additionally, a third-generation VIKIA HIV-1/2 rapid test and a fourth-generation ADVIA Centaur HIV antigen/antibody combo assay were both positive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "a", ...
PMC11739484	Results showed significantly lower promoter methylation levels (p-value < 0.05) for MMP1, MMP7, MMP9, MMP10, MMP11, MMP12, MMP13, MMP14, and MMP25 in SKCM cell lines compared to controls, suggesting hypomethylation as a potential mechanism for their upregulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11748335

Moreover, the proportions of OGs or TSGs in long LOCKs in each methylation domain were mostly similar to the background.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...

PMC11247842

We applied two meta-analysis methods to the clean summary statistics data, a fixed effect model for a meta-analysis using the software METAL and a trans-ethnic meta-regression approach implemented in the software MR-MEGA .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8956657

Fn/c for p65 was determined as above using a BioTek Cytation 5 Cell Imagining Mult-Mode reader and Gen5 Image Prime software, selecting for cells expressing MERS ORF4b or mutants in transfected cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11489175

The armamentarium of drugs available for ovarian carcinoma treatment is quite poor, although it has been recently enriched by the approval of inhibitors of Poly-ADP ribose polymerase (PARP) both for BRCA1 and BCRA2 mutant cancers as well as for the maintenance therapy of non-mutant platinum-sensitive recurrent ovarian ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8481254

Scale bars: 500 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "500", "μm", "." ] } ]

PMC9429973

Summary/Conclusion: We present a robust pre-clinical proof of concept of a potent allogeneic dual CAR T-cell product candidate, UCART20x22, with the potential to 1) overcome common mechanisms of resistance in B-NHL, 2) enable the development of allogeneic CART option for B-NHL patients, 3) reduce the time from treatmen...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

8/23 (35%) had complex cytogenetics, 6/23 (26%) had TP53 mutations, and 5/23 (22%) had therapy-related MDS/CMML.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11767793

Moreover, evidence has accumulated that MNMs behave differently with these assays due to their unique physicochemical properties, leading to unexpected biological effects, interferences with assay readouts, and reactivity with assay components .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Statistical calculations were performed in the R. Results: The results indicate a high heterogeneity of indicators, while the levels of individual mRNAs did not correlate with each other, as well as with the level of leukocytosis or the proportion of blast cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11640555

At the end of incubation with the primary antibodies, the sections were washed with PBS and incubated with a secondary antibody (Santa Cruz Biotechnology, Dallas, TX, USA) for 1 h at room temperature (RT).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11502443

Transfected cells underwent a serum-starve at 37°C for 30 min in 50 μL of serum-free media (DMEM +0.1% BSA) before stimulation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8540692

Briefly, the cells were treated with the analyzed compounds/mixes, in the concentrations allowing >70% of cell survival.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "t...

PMC11144382

In contrast, in experimental neurodegenerative disease and age-related cognitive dysfunction models, treatment with dietary supplements of alpha lipoic acid resulted in downregulation of VCAM1, reduced inflammatory cell infiltration into the CNS and improved memory.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11765879

The observation of the cells throughout the incubation period revealed that at both concentrations, the extract had significantly decreased the number of colonies in both cell lines when compared with the control; in addition, upon visual observation, the sizes of the colonies formed in the treated groups were smaller ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10522430

This study delves into the influence of G. applanatum crude polysaccharide (GACP) extract on proinflammatory cytokines and its induction of apoptosis in HeLa cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...

PMC9250505

Information of primary/secondary antibodies were tabulated in Supplementary Table 9.

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PMC11779605

Cell type is labeled above each plot.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "type", "is", "labeled", "above", "each", "plot", "." ] } ]

PMC11594641

Rab27 was found to regulate the proliferation, migration, invasion, or clone formation of various types of cancer cells .

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PMC7338939

It has also been determined that treatment of melanoma cells with Notch inhibitors with GSIs can result in tumor regression (18, 26, 27).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10873328

Furthermore, the protein level of TGFBI was strongly expressed in OC tissues using standard IHC labeling collected from HPA (Figs. 2j–m).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11774747

They observed cooperation between CD40L, OX40L and pp65 antigen presentation, significantly enhancing the activation and antitumor responses of the CAR-VSTs in vivo (n=8) in a murine model of xenogenic tumor, thanks to the induction of APC maturation upon antigen processing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11545737

with S. flexneri being the first microorganism discovered to induce pyroptosis .

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PMC11320084

a, b) Cell migration of LC cells with TNNT1 knockdown. (

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PMC6468656

We previously identified a peptide hormone, ghrelin, and investigated the function and mechanism of ghrelin in RCC metastasis .

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PMC11684821

These differences may reflect divergences in TCR specificity or variation in accessory molecules on the T cell clones and/or target cells.

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PMC11590870

At the tested concentrations, MOP did not affect Caco-2 proliferation.

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PMC11655498

To successfully replicate and propagate within the infected cells, EBV has evolved various strategies to evade the host’s innate immune surveillance (Figure 2B and Table 2).

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PMC9429973

day 1, prednisone 100 mg orally day 1-5) followed by additional 2 cycles of rituximab every 21 days.

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PMC11267036

Also, DHM inhibited MM tumor growth and EMT, and activated STAT1/RIG-I pathway in vivo.

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PMC11464982

Submitted by Shin Nihon Chemical Co. Ltd. Additional information.

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PMC9429973

Aims: To develop an approach for improved ex vivo HSC expansion using novel bone-lining reinvigorating Mesenchymal Stromal Cells (rMSC)-based culture system.

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PMC11377827

Protein G magnetic beads (25 μl) were added and incubated for a further 2 h at 4 °C.

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PMC11768281

In contrast, a modest humoral response but a strong cellular response can be induced by the majority of viral vector subunit malaria vaccines.

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PMC10748106

Human papillomavirus (HPV) infection is the principal cause of cervical cancer.

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PMC9429973

Aims: Provide updated safety and efficacy data for pts with CML-CP with T315I treated with asciminib monotherapy 200 mg twice daily (BID) after added exposure.

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PMC11695546

The use of coconut oil to avoid or manage Alzheimer's disease is not well-supported by scientific research.

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PMC11711663

This study addresses the limited noninvasive tools for Head and Neck Squamous Cell Carcinoma (HNSCC) progression-free survival (PFS) prediction by identifying Computed Tomography (CT)-based biomarkers for predicting prognosis.

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PMC11531744

First, the heat-map of the 25 genes involved in the construction of the prognostic model in the different risk group was shown in Fig. 5A.

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PMC8140214

Our results also showed that 72hr treatment of HepG2 cells with 50 mM D-glucose significantly increased the level of MDA to about 41%, and quercetin significantly decreased the MDA level in 50 mM D-glucose-treated cells (p<0.05) (Figure 7).

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PMC9739791

FMN was loaded into the Au nanoparticles modified by a C11 thiol linker with terminal triazacyclononane (TACN) moieties.

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PMC11180402

K & L) Colonies of 5637 (SOX2) and 5637 (Vector) cells in soft agar with 20 µM ISO or 0.1% DMSO (K).

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PMC5600151

The formulation developed by Starpharma (Melbourne, Australia), named DEP docetaxel, presented improved tumor targeting and effectiveness against different solid tumors—including breast, ovarian, prostate, and lung—compared to Taxotere, the docetaxel formulation used in the conventional chemotherapy .

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PMC11678130

This finding confirms the results of a previous study that illustrated the efficacy of QUE (130 µM) in improving the antiangiogenic properties of 5-FU (5 µM) in vitro on the HUVEC cell line, and in ovo on the CAM .

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PMC11682172

The quantity and quality of the isolated RNA were assessed (2100 Bioanalyser, Agilent Technologies, Santa Clara, USA).

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PMC10926885

Numerous studies have shown that the degree of immune cell infiltration may be able to predict the prognosis of a tumour. ,

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PMC11741906

Remarkably, higher expression levels of hsa-miR-133b, hsa-miR-512, hsa-miR-200b, and hsa-miR451a were associated with poor overall survival of ovarian cancer patients.

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PMC11381192

p < 0.01, ***p < 0.001.

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PMC10577955

The angiogenic process is regulated at various levels, starting with factors within the tumor microenvironment, followed by the modifications in signaling pathways containing key regulatory molecules as vascular endothelial growth factor (VEGF) expression .

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PMC4270159

Vehicle control.

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PMC11615828

COS7 cells co‐transfected with EMTB‐CFP‐FRB (blue) and indicated mNeon‐FKBP tagged vesicular markers (green) were treated with rapamycin (Rapa, 100 nM) for the inducible vesicle immobilization.

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PMC11461874

LC-MS/MS-based circadian proteome analysis was performed as previous described with some modifications.

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PMC11787355

Notably, depletion of PTPRZ1 results in significant impairment of glioma cell sphere formation in vitro and delays tumor growth in vivo, indicating a strong association of PTPRZ1 with glioma cell stemness.

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PMC11391695

By impeding the activation of KCNN4 and subsequent release of K, ACYP2 in HCC cells inhibits the ERK pathway and impedes the malignant progression of HCC.

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PMC11269933

The Figure 3C demonstrated that the SASA values of the S11 phosphorylated system are lower than that of the wild-type system.

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PMC11612794

Immunoprecipitation using anti-FLAG antibody in AID-based CENP-T conditional knockdown GFP-Dsn1/CENP-C cells expressing 3xFLAG-CENP-T, 3xFLAG-CENP-T, or 3xFLAG-CENP-T. Cells were cultured with IAA for 12 h and nocodazole was added for last 10 h before immunoprecipitation experiments.

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PMC11787355

3PTPRZ1 TCR-T product was persistent, TSCM-abundant, and efficient in target cell killing.a TCR expression on primary human T cells over 3-week period.

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PMC11371747

The moderate protection by 5 µM l-LV (Table 5) indicates that at this concentration, passive diffusion may contribute to l-LV uptake.

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PMC9429973

M. Nowicki, A. Wierzbowska, E. Stec-Martyna, D. Kulczycka-Wojdala, G. Nowicki, A. Szmigielska-Kapłon Department of Hematology, Copernicus Memorial Hospital in Lodz Comprehensive Cancer Center and Traumatology, Poland; Department of Hematology; Central Scientific Laboratory, Medical University of Lodz, Łódź, Poland; Geo...

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PMC9429973

Their median BCR-ABL gene expression before treatment was 79% (range = 0.63-380) that decreased to 3.65% (range = 0.05-20) and 0.750 % (range = 0.002-46) on 3 and 6 months post-treatment.

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PMC9895440

n = 7 donors of n = 2 experiments.

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PMC10529414

The trimmed reads were then aligned to the hg38 reference genome using BWA Aligner with the MEM algorithm.

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PMC10047551

In NSCLC, EGFR and KRAS mutations regulate PD-L1 expression through different cell signal transduction pathways .

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PMC11511922

All data represent one set of triplicates.

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PMC9429973

The patients with MPNs were diagnosed according to the latest WHO criteria.

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PMC11766350

One such transgene is TNF-related apoptosis-inducing ligand (TRAIL), which induces cell death by binding to the DR4 (TRAIL-R1) or DR5 (TRAIL-R2) death receptors .

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PMC11055443

Anti-inflammatory cytokines like IL-10 suppress cAMP production and reduce chloride secretion.

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PMC11583690

MSN@DTX, BPMO@DTX, and free DTX particles were used to evaluate DTX release into PBS (pH 7.4) and CPB (pH 5.5), both containing 0.1 % (v/v) Tween 80 to enhance DTX's solubility .

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PMC11047729

A study on human leukemia cells THP-1 and H937 showed that cordycepin-induced apoptosis influences telomerase, causing its deactivation and the down-regulation of both hTERT and its transcription factors—c-Myc and Sp1.

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PMC9429973

Thus, patients with both risk factors had 5-year FFP rates 73-75% and 5-year OS 81-83%.

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PMC11451940

4 μM (48 h).

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PMC11190238

But what has been of contention is whether these transcriptional repertoires are context specific that there might not be universal master transcription regulators particularly in scenarios with known diverse heterogeneity such as tissue fibrosis and cancer metastasis.

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PMC2614415

Following VE-465 treatment, phoshpo-p53 levels are reduced at doses of 1 nM and higher, indicating an inhibition of Aurora-A activity.

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PMC11653168

Total STAT3 and β-actin were used as loading controls.

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PMC11621565

These changes indicated successful differentiation into dopaminergic-like neurons.

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PMC11180402

K-L) The invasion abilities of 5637 (vector) and 5637 (miR-129 Inhibitor) cells, with or without ISO treatment, were assessed using the Transwell assay (K), and the relative invasion ability was plotted in (L). (

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PMC11543885

The following day, pellet the beads on the magnetic rack and collect the supernatant (flow-through) for further analysis.

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PMC9118379

This yielded 1123 single amino acid variants for this study.

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PMC11772449

Studies (Luo et al., 2016) have confirmed that in patients with high expression of ATG7, due to the activation of autophagy and the increase of intracellular autophagy level, these patients have a poor prognosis and resistance to Sora treatment.

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PMC11740573

Wells A3, D3 and G3 show positive controls and confirm no contamination occurred while preparing the plate.

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PMC11549062

The plaques were categorized into stable and vulnerable types based on ultrasound and histopathological assessments.

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PMC11462929

We generated a genome‐wide copy number alteration map using a previously reported microarray dataset covering 710 K single‐nucleotide polymorphisms in 72 BCP‐ALL cell lines.

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PMC11486946

Ba/F3 cells (RIKEN BRC) and Ba/F3 cells expressing EGFR (a kind gift from Dr. Ryo Iwamoto and Dr. Eisuke Mekata, Osaka University) were cultured at 37 °C in RPMI medium supplemented with 10% FBS and 4 ng/mL mouse IL3 (091-03971, Fuji-Wako, Japan).

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PMC8567602

First, an assay of tumorigenesis initiated by TATCre limb injections at age 4 weeks compared three genotypes of mice that were all heterozygous for hSS2, and wild-type, heterozygous, or homozygous for Smarcb1 floxed.

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PMC11806106

Insertion of the sYFP after position M264 led to a construct which was expressed mainly at the membrane.

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PMC11767725

Specific ML approaches, such as supervised learning algorithms (e.g., random forests, support vector machines) or unsupervised clustering methods, were highlighted for their contributions to advancing precision dermatology.

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PMC10135767

When compared to the control group, the knockdown of Kindlin-3 significantly lengthened the delay and peak times while weakening the peak intensity of calcium signaling in RPMI 8226 cells (Figure 6E–G), suggesting that the blockage of Kindlin-3 could disturb calcium bursting triggered by the interaction of integrin α4β...

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PMC11655536

in (A).

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PMC10197932

As shown in Figure 3A and Figure 3B, 2T Jurkat cells are not able to proliferate as UT controls.

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PMC11564322

3mRNA expression of NFKB2 and PPARγ genes in the leukemia cell lines.

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PMC11476264

The sonicated cell lysates were incubated with purified sFBXO11 or ZEB1-truncated proteins and Ni-NTA beads.

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PMC11703992

PMA induced Jurkat activation, and a significant increase in DDIT4 expression.

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PMC10808409

The optimized values of the variables with the predicted and observed responses.

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PMC10975211

This targeted delivery minimizes off-target effects and improves the therapeutic index of buforin-containing bioconjugates.

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PMC11638288

The research conducted by Chen et al. also demonstrates that in activated NK cells, overexpression of miR-544 suppresses the cytotoxicity against hepatocellular carcinoma cells by directly targeting and downregulating RUNX3, thereby inhibiting NCR1/NKp46 signaling.

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PMC11680049

The formation of primary callus tissue occurred over the entire surface of the shoot segment and also from the mesophyll of the leaf blade located near the central vein (Figure 3a,b and Figure 4a–c).When cultivating primary explants (shoot segments) horizontally in light, callus formation was inhibited, and only in rar...

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PMC6642070

Currently, the definition, epidemiology, diagnosis and management of SAMS are conflicting, which could be improved by further understanding of the pathophysiology of the symptoms.

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PMC11129910

The sections were washed two times for five minutes each with PBST.

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PMC9250505

B Mice were treated daily with vehicle (V), 20 mg/kg NPB (N), 50 mg/kg Olaparib (O), or a combined NPB-Olaparib by i.p.

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PMC9559528

Additionally, a third-generation VIKIA HIV-1/2 rapid test and a fourth-generation ADVIA Centaur HIV antigen/antibody combo assay were both positive.

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PMC11739484

Results showed significantly lower promoter methylation levels (p-value < 0.05) for MMP1, MMP7, MMP9, MMP10, MMP11, MMP12, MMP13, MMP14, and MMP25 in SKCM cell lines compared to controls, suggesting hypomethylation as a potential mechanism for their upregulation.

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