OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC8358006	Interaction loops are contoured in black, and representative genes within the TADs are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interaction", "loops", "are", "contoured", "in", "black", "...
PMC10996034	However, the development of resistance to Taxol severely limits the clinical chemotherapeutic efficacy in patients with EOC (13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...
PMC11655536	A The cell viability of carfilzomib-resistant cell line ARH-77 R and parental cell line ARH-77 treated with carfilzomib for 48 h at the indicated concentration of carfilzomib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10452486	Similarly, the activation of resting T cells with anti-CD3 mAb and PHA resulted in the expression of Face-2 on average from 30 to 65% of T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730	In addition to reducing bioenergetics and inducing intrinsic apoptosis, quercetin also targets mitochondria in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "reducing", "bioenergetics", "a...
PMC9587298	3ESI-MS spectra of anthocyanin standards identified by ESI-MS as [M]: before the trapping experiment: (a) cyanidin-3-glucoside; (b) cyanidin-3-sambubioside; (c) cyanidin-3,5-diglucoside and (d) cyanidin-3-sambubioside-5-glucoside; as well as the formation of mono-methylglyoxal (MGO) adduct of (e) cyanidin-3-glucoside a...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621565	The role of microbiota gained interest when metagenomics studies reported a different pattern of gut microbiota profile in PD patients compared to controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC8984067	The reaction temperature (150°C) for this method was significantly lower than that used in the high-temperature thermal decomposition method .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11301927	We did not observe any differences in alpha and beta diversity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "did", "not", "observe", "any", "differences", "in", "alpha", "and", "beta", ...
PMC5810978	We could not check cell viability, so we only maintained them for a short time (~ 1 day) for BoNoV propagation trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11509309	As a part of our ongoing program on chemical exploration of natural products for anti-prion purposes, several libraries of marine invertebrates and macro-algal extracts from French overseas territories (French Polynesia, Wallis and Futuna) have been screened, as have cyclolipopeptides from Pseudoaltromonas rhizosphaera...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	However, no changes were observed for total, and clonal plasma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "no", "changes", "were", "observed", "for", "total", "...
PMC9429973	Aims: We aim to investigate whether STAT5B also acts as an oncogenic driver in NK cells and establish an NK-cell leukemia model, which would enable the development of treatment options for highly aggressive NK-cell malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9027909	Blastocystis sp., is a eukaryote of the large intestine, which is reported from almost all countries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blastocystis", "sp.", ",", "is", "a", ...
PMC9429973	Male/female ratio was 47% vs 52% vs 28% in no LO/LL vs LO vs LL, respectively (P=0.27), median age 1 vs 11.1 vs 3.1 years (P<10-4), median neutrophil count 0.5 vs 1.2 vs 0.6 G/L (P<10-4), and with concomitant leukopenia in 27% vs 53% vs 36% (P=0.009) or lymphopenia in 3% vs 10% vs 7% of cases (P=0.27).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11451940	Anal.	[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]
PMC9429973	High SPINK2 (SPINK2) patients accounted for 77/172 (44.8%) cases, and low SPINK2 (SPINK2) patients for 95/172(55.2%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7136814	RD (ATCC® CCL-136™) and A-204 (ATCC® HTB-82™) were purchased from American Type Culture Collection (Manassas, VA) and cultured under standard conditions (37°C, 5% CO2) in DMEM High Glucose supplemented with 10% fetal bovine serum.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10944868	C NMR (CDCl3, 100 MHz): δ = 10.4, 22.0, 66.0, 70.2, 101.6, 115.3, 127.5 (2C), 129.4 (2C), 130.8, 131.2, 157.9, 166.4 ppm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574029	I, J Evaluation of cell migration and invasion capabilities using the Transwell assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "I", ",", "J", "Evaluation", "of", "cell", "migration", "and", ...
PMC11577421	For the calculation of the theoretical binding stoichiometry, we divided the total NP surface area by the albumin cross-sectional area, yielding ∼200 albumin molecules per NP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11768927	This disruption of the type-I IFN response enhanced VSVΔ51replication in multiple types of VSV-resistant cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "disruption", "of", "the", "type-I", "IFN", ...
PMC11740207	They can also shed light on differences in cell division behaviors (e.g., the HE) between healthy VSELSCs and transformed VSLSLCs and VSCSLCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11106977	In addition, amyloid beta (Aβ) is known to increase O-GlcNAcylation of c-Fos, a vital component of activator protein-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC11525028	Statistical details of experiments can be found in figure legends and text.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "details", "of", "experiments", "can", "be", "found", "in", "figur...
PMC10976516	This would be ideal for the systemic delivery of large amounts of viruses to metastatic tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "would", "be", "ideal", "for", "the", "sy...
PMC10551595	p < 0.05, p < 0.01, *p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ",", "", "", "p", "<", ...
PMC11509278	In the univariate analysis, the statistical significance (p-value) of each metabolite between the two groups was calculated via a t-test, and the fold change (FC value) of the metabolite between the two groups was calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	The supernatant protein quantity was determined using a BCA assay Equal amounts of protein (30 μg) were resolved by electrophoresis in a 10% or 12% gel and transferred to nitrocellulose membranes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	We defined a small insertion and a small deletion event as shorter than 100 bp and a large-deletion event as larger than 100 bp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11803918	In vivo antimelanoma growth effect of photosensitive hybrid γδ-T exosomes in A375 tumor-bearing nude mice. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "antimelanoma", "growth", "effect", ...
PMC11721295	Next, we interrogated differential expression changes in neutrophils and found that neutrophils in the OFF group increased both in cytokines such as Ccl3 and polarization markers such as Cd274 and Icam1 (Figure 4, F–H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Badalona; H.Universitario de Canarias, Tenerife; H.Universitario Fundación Alcorcón; H.Universitario de Fuenlabrada.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Badalona", ";", "H.Universitario", "de", "Canarias", "...
PMC11591052	Notably, none of these reports investigated the effects of 20E on energy metabolism in muscle cells with respect to the analysis of glycolysis and respiration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10988555	Through the melting profile analysis (Figure S18), it is possible to verify that the addition of Evagreen dye to CT-DNA that has been incubated (with or with 0.1% DMSO) but in the absence of complexes 2-4, allows to obtain a typical melting profile for CT-DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087301	MicroRNA-34a and miR-137 target and repress the expression of Snail in ovarian cancer cells leading to reduced EMT and sphere-forming capacity bringing more favorable clinical outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	There were no MACE for pacritinib, whereas there were for BAT, including in patients treated with ruxolitinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "no", "MACE", ...
PMC10877303	Conversely, all the hit compounds in our study, including Kihadanin B, Robustaflavone, and 3-beta-O-(trans-p-Coumaroyl) maslinic acid, exhibited the structural stability and firmness of the docked complexes over 100 ns of molecular dynamics simulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	Whilst the migratory potential of plasma cells has been well described for some time (Kunkel and Butcher, 2003), and whilst it has been hypothesised that plasma cells might be mobilised by stress or exercise (Dhabhar et al., 2012), this has been difficult to investigate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	Therefore, we asked if COL11A1 also increases the uptake of extracellular fatty acids to promote FAO in ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", ...
PMC11748335	Conversely, H3K9me3 long LOCKs were significantly enriched in L-PMDs in both tumor and normal cell lines (Fig. S5A), consistent with the Roadmap samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739504	Counted cell numbers were as follows: DMSO-treated cells n = 287, garcinol-treated cells n = 248. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Counted", "cell", "numbers", "wer...
PMC11806106	In conclusion, we here introduce a novel tool that could facilitate further, potentially unbiased, analysis of the opioid receptor family from single-cell analysis to multiwell format, providing information not only on affinity of drugs to the receptor, but also on their efficacy in receptor activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574271	D The relative mRNA expression level of RON in bladder cancer cell lines was assessed using quantitative real-time polymerase chain reaction (qRT-PCR, with 5637 cells serving as the control).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC10387886	In ovarian cancer progress and metastasis, TGFβ1 is known to induce EMT, which is accompanied by increased MAPK activity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "ovarian", "...
PMC9878562	It was previously assumed that cancers metastasize through single tumor cells escaping from the primary site arriving at distant tissues and propagating there.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC7452526	The cells were plated in 96-well plates at a density 2×10 cells/well and allowed to adhere overnight at 37 °C (95 % humidity, 5% CO2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10443665	APS decreased MDR1 mRNA expression only in CCRF-CEM/MTX and CCRF-CEM/R cells which were insignificant compared to the positive control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "APS", "decreased", "MDR1", ...
PMC11290772	This phenomenon, as depicted in Supplementary Figure 3, is consistent with findings from previous studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "phenomenon", ",", "as", "depicted", ...
PMC7868205	This can lead to the identification of a safety window intended for the treatment of neoplasms.52 Consequently, assessment of toxicity on various types of cells is a critical point to warrant the safety of such nano-carriers.53,54 Toxicity associated with kidneys is usually tested to identify a drug as they determine t...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	Data are shown as SD ± mean.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "SD", "±", "mean", "." ] } ]
PMC9429973	No treatment-related deaths occurred.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "No", "treatment-related", "deaths", "occurred", "." ] } ]
PMC11588085	Side population was gated by performing the experiment with an ABC transporter inhibitor Reserpine. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Side", "population", "was", "gated", "by", "performing", "t...
PMC11344246	A higher value (yellow) is related to a greater distance from control wells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "higher", "value", "(", "yellow", ")", "is",...
PMC10944868	Antiproliferative activities of tested compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antiproliferative", "activities", "of", "tested", "compounds", "." ] } ]
PMC6364197	CCK-8 reagent was used to test cell cytotoxicity of Jurkat cells cultured on TCPS, UPS and 80 µg/ml CTCPS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCK-8", "reagent", "was", ...
PMC5173112	For each ChIP reaction, 2 × 10 cells were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "ChIP", "reaction", ",", "2", "×", "10", "cells", "were", "used",...
PMC11001582	C9orf72 FTLD/MND n = 34, non-C9orf72 FTLD/MND n = 44, controls n = 24.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C9orf72", "FTLD/MND", "n", "=", "34", ",", "non-...
PMC11541409	This reference supports the longer time of imatinib treatment is effective and safe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "reference", "supports", "the", "longer", "time", "of", "imatinib", ...
PMC10747160	The 96-well plate was returned to the 37 °C humidified incubator for an additional 36 to 48 h. After 36–48 h, the 96-well plate was retrieved from the humidified incubator, and Bright-Glo Luciferase Reagent luminescence assays were performed as described in Section 2.7 above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10761218	In light of the comprehensive assessments documenting the anticancer attributes of W. somnifera , this article presents in vitro comparative investigations into the anticancer potentials of distinct constituents of W. somnifera, specifically the leaf, stem, and root, in the selected cell lines HepG2 and L929.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	C Human albumin secretion was estimated from 24-h cell media using an ELISA kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Human", "albumin", "secretion", "was", "estimated", "from", ...
PMC11477621	Four tested compounds (20, 19a, 14, and 5c) could promote RPMI-8226 cell apoptosis in a dose-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "test...
PMC9429973	Aims: Assess the impact of SARS-CoV-2 vaccination on SAA disease status and to determine the humoral and cellular response to vaccination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...
PMC11541241	As indicated in recent systems, chemical, genetic, and genomic studies on the TOR signalling pathway, phytopathogens with TOR dysfunctions show severe growth defects and nonpathogenicity, which makes the TOR signalling pathway to be developed into an ideal candidate target for controlling plant disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	Harvest cell lysates as noted in Step 5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Harvest", "cell", "lysates", "as", "noted", "in", "Step", "5", "." ] } ]
PMC9429973	Importantly, NK cell function of AML patients is largely diminished due to different mechanisms of tumor-mediated immune suppression and escape.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", ...
PMC11750712	Thus, physiological T cells are a mixture of TRBC1/TRBC2 T cells, at a TRBC1:TRBC2 ratio of approximately 2:3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "physiological",...
PMC9532503	These reports suggest that manganese has a dose-dependent effect on afucosylation, which in turn increases the affinity of the antibody to the FcγRIIIa receptors on effector cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	We observed microtubule filaments extending from the center to the periphery of the chromosome cluster in control COS-7 cells (Fig. 6A, upper).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11783017	The results demonstrate that the Cis/Mn/NH@PGP hydrogels deliver several drugs in physiological response, providing localized, dynamic immunotherapy and chemotherapy effects for OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11637284	The central and most complex TAC subdomain is the OM module.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "central", "and", "most", "complex", "TAC", "subdomain", "is", "the", "OM", ...
PMC11711871	Although the mechanism by which these EETs prevent metabolic diseases is not completely understood, inflammation and chronic diseases, such as cardiovascular diseases, have been associated with increased sEH expression and accelerated conversion of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11626627	The miR-204–3p mimics and inhibitor were obtained from GenePharma, and a non-specific NC (negative control) was also obtained from GenePharma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9784246	The MeOH fraction was found to contain several flavonoids and flavan-3-ol derivatives with known cytotoxic properties, whereas the EtOAc fractions contained triterpene, hydroxycinnamoyl, sterol, and flavanol derivatives with known antileishmanial activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11314247	The aberrant overexpression of HDAC can lead to an epigenetic imbalance associated with cell proliferation in BC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "aberrant", "overexpression", "of", "HDAC",...
PMC9429973	The adverse events reported with DFP+DFX were consistent with what has previously been reported for DFP or DFX monotherapy; no new adverse events were observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Aims: We set out to phenotypically and functionally characterise the ‘stem-like’ sub-population in the KG1a cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Aims", ":", "We", ...
PMC10218459	The relative TUNEL signal was increased in the RD-ES cells with different intensities after the different treatments after 24 h and after 48 h (Figure 6D,H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7090062	Moreover, miR-30a expression decreased both in GIST-882 and GIST-T1 cells after treatment with IM compared to the levels detected in the control (Fig. 1c, d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10587429	1-cc tuberculin syringes (14-826-87, Fisher Scientific, Waltham, MA). -	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1-cc", "tuberculin", "syringes", "(", ...
PMC11317131	Therefore, we continually increased the stringency of our system to challenge the evolving integrases by decreasing gIII promoter strength and increasing the flow rate (Figure 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11173119	Differentiation of iPSCs into macrophages was achieved by adding the cytokines interleukin-3 (IL-3) and macrophage colony-stimulating factor (M-CSF) to the differentiating embryoid bodies (Figure 2A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10443665	CCRF-CEM cells were treated with tragacanthin alone, CCRF-CEM/MTX cells received tragacanthin in combination with MTX at 0.1, and CCRF-CEM/R cells were treated with tragacanthin in combination with MTX at 0.6 μM. Results are shown as mean ± SEM, n = 3. *	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O"...
PMC11788920	The schematic of a model representing different modes of collision between RNAP and dCas9. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "schematic", "of", "a", "model", "representing", "dif...
PMC11023271	LPA has been shown to promote re-epithelialization in excisional skin wound healing models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LPA", "has", "been", "shown", "to", "promote", "re-epithelialization", "in"...
PMC11089031	C WB tested the effects of KD and OE of ZNF692 in 786–0 and Caki-1 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "C", "WB", "tested", "the", "eff...
PMC11790971	For each feature, the associated imaging modality, feature category, and median profiles of the four cell lines are illustrated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each"...
PMC10656496	The impact of immunotherapy in osteosarcoma to date has also been modest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "impact", "of", "immunotherapy", "in", "osteosarcoma", "to", "date", "has"...
PMC6461034	P‐values in red are above a significance threshold of P < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P‐values", "in", "red", "are", "above", "a", "significance", "threshold", "of", ...
PMC11528603	The apoptotic process is initiated by different molecules in intrinsic or extrinsic pathway which then regulate downstream caspase through the cleave process, especially caspase 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4005030	It may exhibit antioxidant activity by both chelating metal transition ions as well as by scavenging free radicals via donating hydrogen atom (H) or electron (e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9684669	Synergistic effects of 666-15 and doxorubicin (Dox) on MDR ovarian cancer cell killing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Synergistic", "effects", "of", "666", "-", ...
PMC11585994	F and G) H&E staining and BCL11B IHC staining of spleens (F) and BM (G) from T-ALL PDX mice treated with G5, G5-sgc8, G5-siBCL11B, G5-sgc8-siBCL11B, or CTR; p < 0.05; p < 0.01; ***p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352311	Esculin targets were obtained from SwissTargetPrediction (http://www.swisstargetprediction.ch/index.php) (accessed on 11 August 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Esculin", "targets", "were", "obtained", "from", "Swis...
PMC11546117	MCF 10A (ATCC CRL10317™) and MCF-7 cells (ATCC) cells were a kind gift from prof.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MCF", "...
PMC7342409	Secondly, the small number of animal models may have affected our results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondly", ",", "the", "small", "number", "of", "animal", "models", "...
PMC11228511	Live-cell imaging studies revealed that lamin B1 and LAP2β reduced the percentage of progerin-expressing cells with NM ruptures from 20 to <6% (Fig. 8C) and reduced the frequency of nuclear blebs from ~16 to <4% (Fig. 8C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592837	Additionally, little is known about pharmacodynamics of antineoplastic drugs in actively replicating tumor cells versus terminally differentiated cells, which might be a prerequisite to assess drug efficacy on the one hand, and unwanted side effects on the other.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784	RPMI-CEM (Human acute lymphoblastic leukemia T lymphocytes), Ramos (Human B lymphocytoma cells), K562 (Human chronic myelogenous leukemia cells), RPMI-8226 (Human multiple myeloma peripheral blood B lymphocytes) and Jurkat (Human T-lymphocyte leukemia cells) were cultured in RPMI 1640 media (Thermo Fisher Scientific, U...	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O"...

PMC8358006

Interaction loops are contoured in black, and representative genes within the TADs are shown.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interaction", "loops", "are", "contoured", "in", "black", "...

PMC10996034

However, the development of resistance to Taxol severely limits the clinical chemotherapeutic efficacy in patients with EOC (13).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...

PMC11655536

A The cell viability of carfilzomib-resistant cell line ARH-77 R and parental cell line ARH-77 treated with carfilzomib for 48 h at the indicated concentration of carfilzomib.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC10452486

Similarly, the activation of resting T cells with anti-CD3 mAb and PHA resulted in the expression of Face-2 on average from 30 to 65% of T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11394730

In addition to reducing bioenergetics and inducing intrinsic apoptosis, quercetin also targets mitochondria in cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "reducing", "bioenergetics", "a...

PMC9587298

3ESI-MS spectra of anthocyanin standards identified by ESI-MS as [M]: before the trapping experiment: (a) cyanidin-3-glucoside; (b) cyanidin-3-sambubioside; (c) cyanidin-3,5-diglucoside and (d) cyanidin-3-sambubioside-5-glucoside; as well as the formation of mono-methylglyoxal (MGO) adduct of (e) cyanidin-3-glucoside a...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11621565

The role of microbiota gained interest when metagenomics studies reported a different pattern of gut microbiota profile in PD patients compared to controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC8984067

The reaction temperature (150°C) for this method was significantly lower than that used in the high-temperature thermal decomposition method .

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PMC11301927

We did not observe any differences in alpha and beta diversity.

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PMC5810978

We could not check cell viability, so we only maintained them for a short time (~ 1 day) for BoNoV propagation trials.

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PMC11509309

As a part of our ongoing program on chemical exploration of natural products for anti-prion purposes, several libraries of marine invertebrates and macro-algal extracts from French overseas territories (French Polynesia, Wallis and Futuna) have been screened, as have cyclolipopeptides from Pseudoaltromonas rhizosphaera...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11472639

However, no changes were observed for total, and clonal plasma cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "no", "changes", "were", "observed", "for", "total", "...

PMC9429973

Aims: We aim to investigate whether STAT5B also acts as an oncogenic driver in NK cells and establish an NK-cell leukemia model, which would enable the development of treatment options for highly aggressive NK-cell malignancies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9027909

Blastocystis sp., is a eukaryote of the large intestine, which is reported from almost all countries.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blastocystis", "sp.", ",", "is", "a", ...

PMC9429973

Male/female ratio was 47% vs 52% vs 28% in no LO/LL vs LO vs LL, respectively (P=0.27), median age 1 vs 11.1 vs 3.1 years (P<10-4), median neutrophil count 0.5 vs 1.2 vs 0.6 G/L (P<10-4), and with concomitant leukopenia in 27% vs 53% vs 36% (P=0.009) or lymphopenia in 3% vs 10% vs 7% of cases (P=0.27).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11451940

Anal.

[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]

PMC9429973

High SPINK2 (SPINK2) patients accounted for 77/172 (44.8%) cases, and low SPINK2 (SPINK2) patients for 95/172(55.2%).

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PMC7136814

RD (ATCC® CCL-136™) and A-204 (ATCC® HTB-82™) were purchased from American Type Culture Collection (Manassas, VA) and cultured under standard conditions (37°C, 5% CO2) in DMEM High Glucose supplemented with 10% fetal bovine serum.

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PMC10944868

C NMR (CDCl3, 100 MHz): δ = 10.4, 22.0, 66.0, 70.2, 101.6, 115.3, 127.5 (2C), 129.4 (2C), 130.8, 131.2, 157.9, 166.4 ppm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11574029

I, J Evaluation of cell migration and invasion capabilities using the Transwell assay.

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PMC11577421

For the calculation of the theoretical binding stoichiometry, we divided the total NP surface area by the albumin cross-sectional area, yielding ∼200 albumin molecules per NP.

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PMC11768927

This disruption of the type-I IFN response enhanced VSVΔ51replication in multiple types of VSV-resistant cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "disruption", "of", "the", "type-I", "IFN", ...

PMC11740207

They can also shed light on differences in cell division behaviors (e.g., the HE) between healthy VSELSCs and transformed VSLSLCs and VSCSLCs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11106977

In addition, amyloid beta (Aβ) is known to increase O-GlcNAcylation of c-Fos, a vital component of activator protein-1.

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PMC11525028

Statistical details of experiments can be found in figure legends and text.

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PMC10976516

This would be ideal for the systemic delivery of large amounts of viruses to metastatic tumors.

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PMC10551595

p < 0.05, **p < 0.01, ***p < 0.001.

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PMC11509278

In the univariate analysis, the statistical significance (p-value) of each metabolite between the two groups was calculated via a t-test, and the fold change (FC value) of the metabolite between the two groups was calculated.

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PMC11095939

The supernatant protein quantity was determined using a BCA assay Equal amounts of protein (30 μg) were resolved by electrophoresis in a 10% or 12% gel and transferred to nitrocellulose membranes.

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PMC11754094

We defined a small insertion and a small deletion event as shorter than 100 bp and a large-deletion event as larger than 100 bp.

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PMC11803918

In vivo antimelanoma growth effect of photosensitive hybrid γδ-T exosomes in A375 tumor-bearing nude mice. (

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PMC11721295

Next, we interrogated differential expression changes in neutrophils and found that neutrophils in the OFF group increased both in cytokines such as Ccl3 and polarization markers such as Cd274 and Icam1 (Figure 4, F–H).

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PMC9429973

Badalona; H.Universitario de Canarias, Tenerife; H.Universitario Fundación Alcorcón; H.Universitario de Fuenlabrada.,

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PMC11591052

Notably, none of these reports investigated the effects of 20E on energy metabolism in muscle cells with respect to the analysis of glycolysis and respiration.

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PMC10988555

Through the melting profile analysis (Figure S18), it is possible to verify that the addition of Evagreen dye to CT-DNA that has been incubated (with or with 0.1% DMSO) but in the absence of complexes 2-4, allows to obtain a typical melting profile for CT-DNA.

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PMC11087301

MicroRNA-34a and miR-137 target and repress the expression of Snail in ovarian cancer cells leading to reduced EMT and sphere-forming capacity bringing more favorable clinical outcome.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

There were no MACE for pacritinib, whereas there were for BAT, including in patients treated with ruxolitinib.

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PMC10877303

Conversely, all the hit compounds in our study, including Kihadanin B, Robustaflavone, and 3-beta-O-(trans-p-Coumaroyl) maslinic acid, exhibited the structural stability and firmness of the docked complexes over 100 ns of molecular dynamics simulation.

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PMC11472639

Whilst the migratory potential of plasma cells has been well described for some time (Kunkel and Butcher, 2003), and whilst it has been hypothesised that plasma cells might be mobilised by stress or exercise (Dhabhar et al., 2012), this has been difficult to investigate.

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PMC7171147

Therefore, we asked if COL11A1 also increases the uptake of extracellular fatty acids to promote FAO in ovarian cancer cells.

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PMC11748335

Conversely, H3K9me3 long LOCKs were significantly enriched in L-PMDs in both tumor and normal cell lines (Fig. S5A), consistent with the Roadmap samples.

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PMC11739504

Counted cell numbers were as follows: DMSO-treated cells n = 287, garcinol-treated cells n = 248. (

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PMC11806106

In conclusion, we here introduce a novel tool that could facilitate further, potentially unbiased, analysis of the opioid receptor family from single-cell analysis to multiwell format, providing information not only on affinity of drugs to the receptor, but also on their efficacy in receptor activation.

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PMC11574271

D The relative mRNA expression level of RON in bladder cancer cell lines was assessed using quantitative real-time polymerase chain reaction (qRT-PCR, with 5637 cells serving as the control).

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PMC10387886

In ovarian cancer progress and metastasis, TGFβ1 is known to induce EMT, which is accompanied by increased MAPK activity .

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PMC9878562

It was previously assumed that cancers metastasize through single tumor cells escaping from the primary site arriving at distant tissues and propagating there.

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PMC7452526

The cells were plated in 96-well plates at a density 2×10 cells/well and allowed to adhere overnight at 37 °C (95 % humidity, 5% CO2).

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PMC10443665

APS decreased MDR1 mRNA expression only in CCRF-CEM/MTX and CCRF-CEM/R cells which were insignificant compared to the positive control group.

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PMC11290772

This phenomenon, as depicted in Supplementary Figure 3, is consistent with findings from previous studies .

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PMC7868205

This can lead to the identification of a safety window intended for the treatment of neoplasms.52 Consequently, assessment of toxicity on various types of cells is a critical point to warrant the safety of such nano-carriers.53,54 Toxicity associated with kidneys is usually tested to identify a drug as they determine t...

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PMC11794568

Data are shown as SD ± mean.

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PMC9429973

No treatment-related deaths occurred.

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PMC11588085

Side population was gated by performing the experiment with an ABC transporter inhibitor Reserpine. (

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PMC11344246

A higher value (yellow) is related to a greater distance from control wells. (

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PMC10944868

Antiproliferative activities of tested compounds.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antiproliferative", "activities", "of", "tested", "compounds", "." ] } ]

PMC6364197

CCK-8 reagent was used to test cell cytotoxicity of Jurkat cells cultured on TCPS, UPS and 80 µg/ml CTCPS.

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PMC5173112

For each ChIP reaction, 2 × 10 cells were used.

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PMC11001582

C9orf72 FTLD/MND n = 34, non-C9orf72 FTLD/MND n = 44, controls n = 24.

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PMC11541409

This reference supports the longer time of imatinib treatment is effective and safe.

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PMC10747160

The 96-well plate was returned to the 37 °C humidified incubator for an additional 36 to 48 h. After 36–48 h, the 96-well plate was retrieved from the humidified incubator, and Bright-Glo Luciferase Reagent luminescence assays were performed as described in Section 2.7 above.

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PMC10761218

In light of the comprehensive assessments documenting the anticancer attributes of W. somnifera , this article presents in vitro comparative investigations into the anticancer potentials of distinct constituents of W. somnifera, specifically the leaf, stem, and root, in the selected cell lines HepG2 and L929.

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PMC10114490

C Human albumin secretion was estimated from 24-h cell media using an ELISA kit.

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PMC11477621

Four tested compounds (20, 19a, 14, and 5c) could promote RPMI-8226 cell apoptosis in a dose-dependent manner.

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PMC9429973

Aims: Assess the impact of SARS-CoV-2 vaccination on SAA disease status and to determine the humoral and cellular response to vaccination.

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PMC11541241

As indicated in recent systems, chemical, genetic, and genomic studies on the TOR signalling pathway, phytopathogens with TOR dysfunctions show severe growth defects and nonpathogenicity, which makes the TOR signalling pathway to be developed into an ideal candidate target for controlling plant disease.

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PMC4270159

Harvest cell lysates as noted in Step 5.

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PMC9429973

Importantly, NK cell function of AML patients is largely diminished due to different mechanisms of tumor-mediated immune suppression and escape.

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PMC11750712

Thus, physiological T cells are a mixture of TRBC1/TRBC2 T cells, at a TRBC1:TRBC2 ratio of approximately 2:3.

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PMC9532503

These reports suggest that manganese has a dose-dependent effect on afucosylation, which in turn increases the affinity of the antibody to the FcγRIIIa receptors on effector cells.

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PMC11786767

We observed microtubule filaments extending from the center to the periphery of the chromosome cluster in control COS-7 cells (Fig. 6A, upper).

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PMC11783017

The results demonstrate that the Cis/Mn/NH@PGP hydrogels deliver several drugs in physiological response, providing localized, dynamic immunotherapy and chemotherapy effects for OS.

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PMC11637284

The central and most complex TAC subdomain is the OM module.

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PMC11711871

Although the mechanism by which these EETs prevent metabolic diseases is not completely understood, inflammation and chronic diseases, such as cardiovascular diseases, have been associated with increased sEH expression and accelerated conversion of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) .

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PMC11626627

The miR-204–3p mimics and inhibitor were obtained from GenePharma, and a non-specific NC (negative control) was also obtained from GenePharma.

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PMC9784246

The MeOH fraction was found to contain several flavonoids and flavan-3-ol derivatives with known cytotoxic properties, whereas the EtOAc fractions contained triterpene, hydroxycinnamoyl, sterol, and flavanol derivatives with known antileishmanial activity.

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PMC11314247

The aberrant overexpression of HDAC can lead to an epigenetic imbalance associated with cell proliferation in BC .

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PMC9429973

The adverse events reported with DFP+DFX were consistent with what has previously been reported for DFP or DFX monotherapy; no new adverse events were observed.

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PMC9429973

Aims: We set out to phenotypically and functionally characterise the ‘stem-like’ sub-population in the KG1a cell line.

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PMC10218459

The relative TUNEL signal was increased in the RD-ES cells with different intensities after the different treatments after 24 h and after 48 h (Figure 6D,H).

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PMC7090062

Moreover, miR-30a expression decreased both in GIST-882 and GIST-T1 cells after treatment with IM compared to the levels detected in the control (Fig. 1c, d).

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PMC10587429

1-cc tuberculin syringes (14-826-87, Fisher Scientific, Waltham, MA). -

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PMC11317131

Therefore, we continually increased the stringency of our system to challenge the evolving integrases by decreasing gIII promoter strength and increasing the flow rate (Figure 3A).

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PMC11173119

Differentiation of iPSCs into macrophages was achieved by adding the cytokines interleukin-3 (IL-3) and macrophage colony-stimulating factor (M-CSF) to the differentiating embryoid bodies (Figure 2A,B).

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PMC10443665

CCRF-CEM cells were treated with tragacanthin alone, CCRF-CEM/MTX cells received tragacanthin in combination with MTX at 0.1, and CCRF-CEM/R cells were treated with tragacanthin in combination with MTX at 0.6 μM. Results are shown as mean ± SEM, n = 3. *

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PMC11788920

The schematic of a model representing different modes of collision between RNAP and dCas9. (

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PMC11023271

LPA has been shown to promote re-epithelialization in excisional skin wound healing models .

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PMC11089031

C WB tested the effects of KD and OE of ZNF692 in 786–0 and Caki-1 cell lines.

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PMC11790971

For each feature, the associated imaging modality, feature category, and median profiles of the four cell lines are illustrated.

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PMC10656496

The impact of immunotherapy in osteosarcoma to date has also been modest.

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PMC6461034

P‐values in red are above a significance threshold of P < 0.05.

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PMC11528603

The apoptotic process is initiated by different molecules in intrinsic or extrinsic pathway which then regulate downstream caspase through the cleave process, especially caspase 3.

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PMC4005030

It may exhibit antioxidant activity by both chelating metal transition ions as well as by scavenging free radicals via donating hydrogen atom (H) or electron (e).

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PMC9684669

Synergistic effects of 666-15 and doxorubicin (Dox) on MDR ovarian cancer cell killing.

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PMC11585994

F and G) H&E staining and BCL11B IHC staining of spleens (F) and BM (G) from T-ALL PDX mice treated with G5, G5-sgc8, G5-siBCL11B, G5-sgc8-siBCL11B, or CTR; *p < 0.05; **p < 0.01; ****p < 0.0001.

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PMC11352311

Esculin targets were obtained from SwissTargetPrediction (http://www.swisstargetprediction.ch/index.php) (accessed on 11 August 2024).

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PMC11546117

MCF 10A (ATCC CRL10317™) and MCF-7 cells (ATCC) cells were a kind gift from prof.

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PMC7342409

Secondly, the small number of animal models may have affected our results.

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PMC11228511

Live-cell imaging studies revealed that lamin B1 and LAP2β reduced the percentage of progerin-expressing cells with NM ruptures from 20 to <6% (Fig. 8C) and reduced the frequency of nuclear blebs from ~16 to <4% (Fig. 8C).

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PMC11592837

Additionally, little is known about pharmacodynamics of antineoplastic drugs in actively replicating tumor cells versus terminally differentiated cells, which might be a prerequisite to assess drug efficacy on the one hand, and unwanted side effects on the other.

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PMC11754784

RPMI-CEM (Human acute lymphoblastic leukemia T lymphocytes), Ramos (Human B lymphocytoma cells), K562 (Human chronic myelogenous leukemia cells), RPMI-8226 (Human multiple myeloma peripheral blood B lymphocytes) and Jurkat (Human T-lymphocyte leukemia cells) were cultured in RPMI 1640 media (Thermo Fisher Scientific, U...

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