OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10759659	b ARID1A knockdown by siRNA in HepG2/2.2.15 cell line was confirmed by Western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "ARID1A", "knockdown", "by", "siRNA", "in", "HepG2/2.2.15...
PMC11095939	Subsequent analyses for IF and cell cycle analysis were also performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequent", "analyses", "for", "IF", "and", "cell", "cycle", "analysis", "were", "al...
PMC9429973	We used this approach to confirm functional defects in primary cells isolated from patients harboring a novel variant, suggesting that the in vitro profiling approach can potentially drive identification of pathogenic variants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11437637	All P-values were two-sided, and P-value < 0.05 indicated a statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "P-values", "were", "two-sided", ",", "and", "P-value", "<...
PMC11740207	The EpibCs also generate primordial germ cells (PGCs), which in humans appear around the second to third week of embryonic development, originating from the epiblast.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10196713	It was revealed that the extent of lipid peroxidation was significantly increased by treatment with cisplatin in OVK18 cells but not in OVK18cis cells (Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "...
PMC11708541	After every treatment, the intracellular K content increased in both cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "every", "treatment", ",", "the", "intracellular", "K", "content", ...
PMC9512971	The dose of camostat mesilate was chosen based on (1) preclinical half maximal effective concentration (EC50) values, which determined the clinical target exposures; (2) modeling and simulation to predict high dose exposure in the clinic; and (3) results of a phase 1 study of the safety and pharmacokinetics of camostat...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	n = 5 mice/group; n.s.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", "mice/group", ";", "n.s", ".", "," ] } ]
PMC6799808	Similar results were observed in at least three independent experiments GLPT inhibits mTORC1/2 signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "results", "were", "observed", "in", "at", "least...
PMC11474209	Algal toxins may be released by degrading cyanobacteria, which can be dangerous to aquatic and terrestrial life .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Algal", "toxins", "may", "be", "releas...
PMC10587429	Monitor tumor growth by IVIS imaging once a week.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Monitor", "tumor", "growth", "by", "IVIS", "imaging", "once", "a", "week", "." ] } ]
PMC10203589	In the progression of malignant pleural mesothelioma (MPM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "progression", "of", "malignant", "pleural", "mesothelioma", "(", "MPM", ")", ...
PMC11676169	We found a dose-dependent increase in the acetylation status of KU70 (K532) following ERG245 treatment, often associated with pronounced DNA damage (γH2AX) (Figure 4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The expression of α-globin was reduced in the BM and spleen of Tfr2-deficient mice: this partially rescued the unbalance with β-globin, contributing to the more effective erythropoiesis and leading to an improved RBCs morphology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Scrambled/nontargeting (NT) sgRNAs (Synthego) were used a negative control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scrambled/nontargeting", "(", "NT", ")", "sgRNAs", "(", "Synthego", ")", ...
PMC9429973	Results: A 4-year old boy manifested symptoms of anemia and the analysis of hematological parameters revealed low levels of hemoglobin, MCV and MCH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9412887	However, how to overcome drug resistance of cancer is still an unsolved medical problem in clinical treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "how", "to", "overcome"...
PMC9429973	R. Yeolyan.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "R.", "Yeolyan", "." ] } ]
PMC8662250	NLRP3 protein, as part of pattern recognition receptors (PRR), is a NOD‐like receptor containing the pyrin effector domain able to trigger and participate in inflammasome formation (Kelley et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median age was 57 (19-82) years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "was", "57", "(", "19", "-", "82", ")", "years", "...
PMC7612475	Significant differences between quantified data were assessed using multiple two-tailed t tests, with post hoc Holm–Šidák multiple comparisons tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", ...
PMC9429973	Median age at index was 71.0 for the FEDR group and 70.0 years for the non-FEDR group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "age", "at", "index", "was", "71.0...
PMC11549062	Therefore, we tested the impact of PTP1B/Rab5 signaling pathway on apoptosis using propidium iodide (PI) staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "tested", ...
PMC11761919	As shown in Fig. 5F, the viral load in the liver of chickens immunized with E. faecalis/Fiber2, Micro-E/Fiber2, Micro-E/Fiber2-inulin and Micro-E/Fiber2-PINs was 3.4 × 10, 2.0 × 10, 1.8 × 10 and 2.2 × 10 copies/mg, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6102174	Yin-Chen is a famous TCM that has been used to treat jaundice in China for thousands of years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yin-Chen", "is", "a", "famous", "TCM",...
PMC11240052	This phenomenon was the same as the effect of circ-0008285 in ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "phenomenon", "was", "the", "same", "as", "the", "effect"...
PMC11441402	indicates statistically significantly different value compared to other methods, determined by one-way ANOVA with Tukey’s multiple comparisons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "indicates", "statistically", "significa...
PMC11696576	The involvement of PLA2s in various inflammatory conditions renders them attractive targets for the development of medicinal agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "involvement", "of", "PLA2s", "i...
PMC11697703	We found that N2A cells significantly upregulated expression of miR-193b and miR-365 after transfection with Fezf2 compared to control transfections (Figure 1C; miR-193b 4.81-fold upregulation; miR-365 2.53-fold upregulation).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	Data are means ± SEM (n = 8–9 per group). ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "means", "±", "SEM", "(", "n", "=", ...
PMC11578343	Thus, we fabricated multiple devices with different zone arrangements and measured MCF‐7 cells to determine the effect of perturbation order and measurement duration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11489351	The amount of NADH generated is used to backcalculate the milliunits/ml of lactate dehydrogenase activity in the biological sample using a linear regression of known standards.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11742864	Due to their potential nutritional support and anti-inflammatory and anti-tumor roles, ω-3 LCPUFAs are potentially useful therapeutic agents either by themselves or in combination with other therapeutical strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10998613	The respective green and red emitted photons were detected using a home-built confocal detection unit with a 50 µm confocal pinhole and dichroic beam splitter (LM01-503-25, Semrock).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11626627	Not applicable.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Not", "applicable", "." ] } ]
PMC11413393	Trypsin (1 μg/sample; diluted in 50 mM NH4HCO3) was added to the beads and samples were incubated for 16 h at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583010	Ten nmol/L of horseradish peroxidase (HRP)-conjugated antibodies were incubated for 2 hours at 25°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ten", "nmol/L", "of", "horseradish", "peroxidase", "(H...
PMC11365983	Quantification above each gel: fold change in signal, normalized to actin, relative to wild-type.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "above", "each", "gel", ":", ...
PMC11509309	PK digestion was stopped after 30 min by the addition of 4 mM of the anti-protease Pefabloc (Sigma Aldrich, #30827-99-7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	Disturbances inside mitochondria may result in sudden alterations of genetic and epigenetic mechanisms, resulting in disease development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Disturbances", "inside", "mitochondria", "ma...
PMC9672323	In addition, investigations on the effect of piroxicam on A-172 cell line showed a reduction in the fraction of cells in the G2/M phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC7642379	Log transformed normalized data by DESeq2 was used for cell line clustering and calculation of Euclidean distances of samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Log", "transformed", "normalized", ...
PMC11534035	Adjuvant radiochemotherapy or chemoradiotherapy is indicated in cases where clear margins cannot be achieved with surgery alone, or in tumors that have metastasized to regional or distant lymph nodes (4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9954564	The second SNP rs2114511 involved in the epistatic interaction corresponds to a synonymous variant from the LILRB1 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "second", "SNP", "rs2114511", "i...
PMC9424261	Briefly, CA sensitizes ferroptosis by upregulating HERPUD1 in liver cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "CA", "sensitizes", "ferroptosis", "by", "upregulating", "HERPUD1", ...
PMC7081114	Functional experiments showed that KIF21B knockdown remarkably suppressed cell proliferation and induced apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "experiments", "showed", "that", "KIF21B", "knockdown", "remarkably"...
PMC11286266	For the ATF6α activator screen, conducted under ER stress conditions, less than 2% of cells that showed a XBP1s::mCherry; BiP::sfGFP phenotype were selected for analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791478	Mortality, clinical observations, body weights, food consumption, ophthalmology, electrocardiology, clinical pathology parameters (hematology, coagulation, clinical chemistry, and urinalysis), antidrug antibody analysis, TK parameters (intact XB002 and total antibody), organ weights, and macroscopic and microscopic exa...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634794	Deacetylation process targeting LAMP1 promotes AGG-induced lipolysis-dependent generation FFAs thereby promoting senescence specifically in prostate cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Deacetylation", "process", "targeting", "LAMP1", "promotes",...
PMC11627060	TQ-BSA NPs reduce colony formation in the A549 lung cancer cell line in a dose-dependent manner relative to the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TQ-BSA", "NPs"...
PMC10335954	A GSEA results showing differential enrichment of genes related to the cell cycle, p53-dependent pathways, cytokine and receptor binding, and JAK/STAT signaling cascade in GC cases with high TRIP13 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687167	In turn, PCSK9 upregulated the TLR4/NF-κB signaling pathway and promoted inflammatory responses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "turn", ",", "PCSK9", "upregulated", "the", "TLR4/NF-κB", "signaling",...
PMC11772449	Here we choose SynergyFinder (https://synergyfinder.fimm.fi), a computer online analysis platform first released in 2017 and updated in 2020, for calculation and analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7823217	For instance, CAFs that affect tumor microenvironment are the most common component of cancer stroma mainly in breast and pancreatic cancer, MRC-5 fibroblasts and OVCAR-5 in human ovarian cancer cell models, a set of cancer and stromal cells including U87MG glioblastoma cells, MM6 monocyte/macrophages, glioblastoma ste...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC10969097	Identification: The study selection process began with an examination of the title and abstract information from the Web of Science and PubMed databases, as well as clinical trials from ClinicalTrials.gov and ICTRP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087301	Eventually, in a combined in vitro and mouse orthotopic model investigation by Yang et al., P2X purinoceptor 7 (P2 × 7R) was found to promote CRC cell migration and proliferation by recruiting TAMs and activating cytokine upregulation via NF-κB pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11186948	Slides were washed with PBT, incubated for 1 h and 30 min with Alexa-488 anti-Rabbit secondary antibody (1:250, #6441-30 SouthernBiotech), washed again in PBT and mounted with Everbrite Mounting Medium with DAPI (#23,002, Biotium).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11733919	Bars indicate SD, n = 3, *p < 0.05 compared to senescence control (ANOVA and Dunnett’s a posteriori test). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8358176	In addition, we assessed the mRNA levels of TNF superfamily members in Jurkat cells before and after treatment in rats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition...
PMC6642070	Alt-text: Unlabelled Box Statins are among the most widely prescribed drugs worldwide and are generally well tolerated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alt-text", ":", "Unlabelled", "Box", "...
PMC11607638	Also note that cholecystokinin stimulation was readily washed out in perifused SKR‐CHO‐K1 cells (Figure 6), but SK‐elicited cytosolic calcium oscillations showed a significant lag time already at lower concentrations (Figures 4 and 5) and the stimulation was long‐lasting even after wash‐out (Figures 4, 5, 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	Among the potential GA-interacting proteins (Supporting Information Table S1), HSP90 and USP2, two proteins related to protein degradation, attract our attention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11742431	Subsequently, MCF‐7 (as control), MBA‐MD‐231, SV‐HUC‐1, UMUC‐3, T24, 5637, A375, and HeLa cells were selected to validate the protein expression levels of PD‐L1, where SV‐HUC‐1, UMUC‐3, T24 and 5637 were bladder cell lines.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", ...
PMC9429973	Other causes of death included cardiac disorders (n = 1), neoplasms (n = 4; acute myeloid leukemia, metastatic urothelial carcinoma of the kidney, metastatic malignant neoplasm of the lung and non-small cell lung carcinoma) and respiratory disorders (n = 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2944824	When apoptosis was induced with the mitochondrial stressor staurosporine and endoplasmic reticulum stressor (ER) tunicamycin , forced expression of Hr resulted in higher cell viability in COS cells (supplementary data figure S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6267596	a & b) Cell cycle analyses of U2932 & VAL cells respectively after treatment with 50nM alisertib for 4 days followed by recovery in the absence of drug up to 30-days shows that DLBCL cells establish a diploid 2n-near aneuploid population. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC5025404	The transfection efficiency was evaluated visually using a CKX41 microscope (Olympus, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transfection", "efficiency", "was", "evaluated", "visually...
PMC11283030	What's more, we also found that provision of acetyl-CoA, the product of ACLY, could activate AKT/mTORC1 pathway in ACLY knockdown ccRCC cells, which suggests the potential mechanism that ACLY controls acetyl-CoA level to regulate AKT/mTORC1 pathway in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: This study involved 197 Chinese ITP pediatric patients (discovery cohort) and 220 healthy controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "This", "study", "invol...
PMC11442172	They found that 3D spheroids cultured in Plasmax had a metabolic profile closest to that of the tumors, suggesting that 3D culture in a physiological medium better approximates the tumor’s metabolic phenotype (27).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Thirty-one (97%) patients experienced ≥1 AE, 25 (78%) had Grade ≥3 AEs, and 6 (19%) had serious AEs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705630	When the confluence reached 80-90%, the wound was created by scratching with 10 µl pipette tip.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "confluence", ...
PMC7504302	Consistent with previous reports, the EMT gene signature was able to define distinct molecular subgroups of MPMs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistent", "with", "previous", "reports", ...
PMC9847912	GSK232 or water for the no-drug controls was added (22 μl per well, 4 wells per drug concentration), and the plates were incubated at 37°C in 5% CO2 for 60 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	Nevertheless, a minor amount of non-zero, non-diagonal elements in the confusion matrix was present for DPDLB, indicating slight inaccuracy in the classification of BC subtype cell states, brought about by the low data dimensionality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10073922	The formation of Sur-P-NDRG2 was validated using colony PCR and sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "formation", "of", "Sur-P-NDRG2", "was", "validated", "using", "colony", "PCR", ...
PMC11407042	Gently moving the dishes or wrapping the plate and then observing the cell distribution under the inverted microscope before incubation would help to avoid cell clusters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11413393	RBP: RNA-binding protein; aDMA: asymmetric dimethylation; Me: methyl group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RBP", ":", "RNA-binding", "protein", ";", "aDMA", ":", "asymmetr...
PMC11489175	This feature renders AMSH an interesting target for therapeutic intervention 65.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "feature", "renders", "AMSH", "an", "interesting", "target", "for", "therapeutic", ...
PMC10114490	Values correspond to the average of at least two experiments with three replicates each. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "correspond", "to", "the", "average", "of", "at", ...
PMC9786247	Thereafter, the GE numbers of all the assessed strains significantly increased by two to four orders of magnitude until 14 d p.i.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11453018	Among all the parameters, only glucose showed a slight upregulation in the iP300w-treated group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "all", "the", "parameters", ",", "only", "glucose",...
PMC11578343	Once a resist template of the electrodes and contact pads were patterned onto a glass substrate, electron‐gun evaporation was used to deposit a thin film of 75/250/250 Å Ti (titanium)/Pt/Au and a lift‐off was performed to remove the excess metal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720808	To further verify the effect of SCU on OS cell proliferation, we conducted an EdU assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "verify", "the", "effect", ...
PMC11804588	However, the resolution of this approach is constrained by the uneven distribution of GpC sites within the TF binding sites as well as the endogenous cytosine methylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	Cells were treated with vehicle or CXCL12 (50 nM) for 30 min at 37 °C and FLAG-CXCR4 endocytosis was measured by ELISA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8270637	Its role is to be dephosphorylated by calcineurin (CaN) and then translocate to the nucleus to regulate gene transcription.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "role", "is...
PMC11190538	Some chemotherapeutic medicines cause apoptosis in target cells by generating free radicals; antioxidants, on the other hand, can scavenge these radical molecules and limit the side effects of therapeutic agents .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697703	In particular, the molecular mechanisms of dendritic development in specific cortical projection neuron subtypes represent the least understood aspect of cortical projection neuron development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11534035	However, when the concentration of G1 was increased to 2.5 μM, the reduction in colonies was drastic, and on statistical analysis, became significant (M=3.222±1.392 colonies vs. control; p<0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656048	MG63 and 143B cells were treated with shikonin (1.5 uM) in the presence or absence of Fer-1 (10 uM) for 24 h, and CCK-8 results showed that Fer-1 could partially reverse shikonin induced reduction in OS cell viability (Figures 2A, B).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	We obtained primary CLL cells from patients before and during treatment with ofatumumab on a clinical study conducted at the NIH (NCT01145209) and used lymphoma cell lines HBL2 (Mantle Cell Lymphoma) and SUDHL6 (Diffuse Large B cell Lymphoma) to test in vitro and in vivo efficacy of anti-C3d antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9351137	The observed relocation of CRS to the mitotic apparatus during cell cycle progression may be interpreted as result of passive accumulation of proteins to be disposed of.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, TET2 LOF is not limited to leukemias.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "TET2", "LOF", "is", "not", "limited", "to", "leukemias", "." ] } ]
PMC10669966	Interestingly, a highly homologous pathway, the insulin signaling pathway, was observed as the second-most-upregulated pathway in our analysis, after the phospholipase C-mediated cascade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	In brief, two-day-old neonatal mice (WT or Pla2g4d-deficient) were sacrificed via decapitation and the skin was peeled off using forceps and scissors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	The median number of bleeding episodes in the past 5 years was 0 (0-1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "number", "of", "bleed...
PMC11098378	N-terminal GFP-IpaH4 was constructed through Gateway cloning into pEGFP-C2 (for mammalian expression), then PCR amplified using primers introducing SacII/PacI sites and cloned into pDGOpIE2 (for insect cell expression).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At C2D1 EOI, most responders had a reduction in sBCMA relative to baseline, with the pts who achieved sCR having the greatest decrease (median: –92.10%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10759659

b ARID1A knockdown by siRNA in HepG2/2.2.15 cell line was confirmed by Western blotting.

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PMC11095939

Subsequent analyses for IF and cell cycle analysis were also performed.

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PMC9429973

We used this approach to confirm functional defects in primary cells isolated from patients harboring a novel variant, suggesting that the in vitro profiling approach can potentially drive identification of pathogenic variants.

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PMC11437637

All P-values were two-sided, and P-value < 0.05 indicated a statistically significant difference.

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PMC11740207

The EpibCs also generate primordial germ cells (PGCs), which in humans appear around the second to third week of embryonic development, originating from the epiblast.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10196713

It was revealed that the extent of lipid peroxidation was significantly increased by treatment with cisplatin in OVK18 cells but not in OVK18cis cells (Fig. 3B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "...

PMC11708541

After every treatment, the intracellular K content increased in both cell lines.

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PMC9512971

The dose of camostat mesilate was chosen based on (1) preclinical half maximal effective concentration (EC50) values, which determined the clinical target exposures; (2) modeling and simulation to predict high dose exposure in the clinic; and (3) results of a phase 1 study of the safety and pharmacokinetics of camostat...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11095939

n = 5 mice/group; n.s.,

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PMC6799808

Similar results were observed in at least three independent experiments GLPT inhibits mTORC1/2 signaling pathways.

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PMC11474209

Algal toxins may be released by degrading cyanobacteria, which can be dangerous to aquatic and terrestrial life .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Algal", "toxins", "may", "be", "releas...

PMC10587429

Monitor tumor growth by IVIS imaging once a week.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Monitor", "tumor", "growth", "by", "IVIS", "imaging", "once", "a", "week", "." ] } ]

PMC10203589

In the progression of malignant pleural mesothelioma (MPM).

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PMC11676169

We found a dose-dependent increase in the acetylation status of KU70 (K532) following ERG245 treatment, often associated with pronounced DNA damage (γH2AX) (Figure 4E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The expression of α-globin was reduced in the BM and spleen of Tfr2-deficient mice: this partially rescued the unbalance with β-globin, contributing to the more effective erythropoiesis and leading to an improved RBCs morphology.

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PMC11188874

Scrambled/nontargeting (NT) sgRNAs (Synthego) were used a negative control.

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PMC9429973

Results: A 4-year old boy manifested symptoms of anemia and the analysis of hematological parameters revealed low levels of hemoglobin, MCV and MCH.

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PMC9412887

However, how to overcome drug resistance of cancer is still an unsolved medical problem in clinical treatment.

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PMC9429973

R. Yeolyan.

[ { "tags": [ "O", "O", "O" ], "tokens": [ "R.", "Yeolyan", "." ] } ]

PMC8662250

NLRP3 protein, as part of pattern recognition receptors (PRR), is a NOD‐like receptor containing the pyrin effector domain able to trigger and participate in inflammasome formation (Kelley et al., 2019).

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PMC9429973

The median age was 57 (19-82) years.

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PMC7612475

Significant differences between quantified data were assessed using multiple two-tailed t tests, with post hoc Holm–Šidák multiple comparisons tests.

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PMC9429973

Median age at index was 71.0 for the FEDR group and 70.0 years for the non-FEDR group.

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PMC11549062

Therefore, we tested the impact of PTP1B/Rab5 signaling pathway on apoptosis using propidium iodide (PI) staining.

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PMC11761919

As shown in Fig. 5F, the viral load in the liver of chickens immunized with E. faecalis/Fiber2, Micro-E/Fiber2, Micro-E/Fiber2-inulin and Micro-E/Fiber2-PINs was 3.4 × 10, 2.0 × 10, 1.8 × 10 and 2.2 × 10 copies/mg, respectively.

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PMC6102174

Yin-Chen is a famous TCM that has been used to treat jaundice in China for thousands of years.

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PMC11240052

This phenomenon was the same as the effect of circ-0008285 in ovarian cancer cells.

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PMC11441402

indicates statistically significantly different value compared to other methods, determined by one-way ANOVA with Tukey’s multiple comparisons.

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PMC11696576

The involvement of PLA2s in various inflammatory conditions renders them attractive targets for the development of medicinal agents.

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PMC11697703

We found that N2A cells significantly upregulated expression of miR-193b and miR-365 after transfection with Fezf2 compared to control transfections (Figure 1C; miR-193b 4.81-fold upregulation; miR-365 2.53-fold upregulation).

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PMC6684588

Data are means ± SEM (n = 8–9 per group). ***

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PMC11578343

Thus, we fabricated multiple devices with different zone arrangements and measured MCF‐7 cells to determine the effect of perturbation order and measurement duration.

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PMC11489351

The amount of NADH generated is used to backcalculate the milliunits/ml of lactate dehydrogenase activity in the biological sample using a linear regression of known standards.

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PMC11742864

Due to their potential nutritional support and anti-inflammatory and anti-tumor roles, ω-3 LCPUFAs are potentially useful therapeutic agents either by themselves or in combination with other therapeutical strategies.

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PMC10998613

The respective green and red emitted photons were detected using a home-built confocal detection unit with a 50 µm confocal pinhole and dichroic beam splitter (LM01-503-25, Semrock).

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PMC11626627

Not applicable.

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PMC11413393

Trypsin (1 μg/sample; diluted in 50 mM NH4HCO3) was added to the beads and samples were incubated for 16 h at 37 °C.

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PMC11583010

Ten nmol/L of horseradish peroxidase (HRP)-conjugated antibodies were incubated for 2 hours at 25°C.

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PMC11365983

Quantification above each gel: fold change in signal, normalized to actin, relative to wild-type.

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PMC11509309

PK digestion was stopped after 30 min by the addition of 4 mM of the anti-protease Pefabloc (Sigma Aldrich, #30827-99-7).

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PMC11474209

Disturbances inside mitochondria may result in sudden alterations of genetic and epigenetic mechanisms, resulting in disease development.

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PMC9672323

In addition, investigations on the effect of piroxicam on A-172 cell line showed a reduction in the fraction of cells in the G2/M phase.

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PMC7642379

Log transformed normalized data by DESeq2 was used for cell line clustering and calculation of Euclidean distances of samples.

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PMC11534035

Adjuvant radiochemotherapy or chemoradiotherapy is indicated in cases where clear margins cannot be achieved with surgery alone, or in tumors that have metastasized to regional or distant lymph nodes (4).

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PMC9954564

The second SNP rs2114511 involved in the epistatic interaction corresponds to a synonymous variant from the LILRB1 gene.

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PMC9424261

Briefly, CA sensitizes ferroptosis by upregulating HERPUD1 in liver cancer cells.

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PMC7081114

Functional experiments showed that KIF21B knockdown remarkably suppressed cell proliferation and induced apoptosis.

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PMC11286266

For the ATF6α activator screen, conducted under ER stress conditions, less than 2% of cells that showed a XBP1s::mCherry; BiP::sfGFP phenotype were selected for analysis.

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PMC11791478

Mortality, clinical observations, body weights, food consumption, ophthalmology, electrocardiology, clinical pathology parameters (hematology, coagulation, clinical chemistry, and urinalysis), antidrug antibody analysis, TK parameters (intact XB002 and total antibody), organ weights, and macroscopic and microscopic exa...

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PMC11634794

Deacetylation process targeting LAMP1 promotes AGG-induced lipolysis-dependent generation FFAs thereby promoting senescence specifically in prostate cancer.

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PMC11627060

TQ-BSA NPs reduce colony formation in the A549 lung cancer cell line in a dose-dependent manner relative to the control group.

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PMC10335954

A GSEA results showing differential enrichment of genes related to the cell cycle, p53-dependent pathways, cytokine and receptor binding, and JAK/STAT signaling cascade in GC cases with high TRIP13 expression.

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PMC11687167

In turn, PCSK9 upregulated the TLR4/NF-κB signaling pathway and promoted inflammatory responses .

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PMC11772449

Here we choose SynergyFinder (https://synergyfinder.fimm.fi), a computer online analysis platform first released in 2017 and updated in 2020, for calculation and analysis.

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PMC7823217

For instance, CAFs that affect tumor microenvironment are the most common component of cancer stroma mainly in breast and pancreatic cancer, MRC-5 fibroblasts and OVCAR-5 in human ovarian cancer cell models, a set of cancer and stromal cells including U87MG glioblastoma cells, MM6 monocyte/macrophages, glioblastoma ste...

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PMC10969097

Identification: The study selection process began with an examination of the title and abstract information from the Web of Science and PubMed databases, as well as clinical trials from ClinicalTrials.gov and ICTRP.

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PMC11087301

Eventually, in a combined in vitro and mouse orthotopic model investigation by Yang et al., P2X purinoceptor 7 (P2 × 7R) was found to promote CRC cell migration and proliferation by recruiting TAMs and activating cytokine upregulation via NF-κB pathway.

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PMC11186948

Slides were washed with PBT, incubated for 1 h and 30 min with Alexa-488 anti-Rabbit secondary antibody (1:250, #6441-30 SouthernBiotech), washed again in PBT and mounted with Everbrite Mounting Medium with DAPI (#23,002, Biotium).

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PMC11733919

Bars indicate SD, n = 3, *p < 0.05 compared to senescence control (ANOVA and Dunnett’s a posteriori test). (

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PMC8358176

In addition, we assessed the mRNA levels of TNF superfamily members in Jurkat cells before and after treatment in rats.

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PMC6642070

Alt-text: Unlabelled Box Statins are among the most widely prescribed drugs worldwide and are generally well tolerated.

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PMC11607638

Also note that cholecystokinin stimulation was readily washed out in perifused SKR‐CHO‐K1 cells (Figure 6), but SK‐elicited cytosolic calcium oscillations showed a significant lag time already at lower concentrations (Figures 4 and 5) and the stimulation was long‐lasting even after wash‐out (Figures 4, 5, 6).

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PMC11725127

Among the potential GA-interacting proteins (Supporting Information Table S1), HSP90 and USP2, two proteins related to protein degradation, attract our attention.

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PMC11742431

Subsequently, MCF‐7 (as control), MBA‐MD‐231, SV‐HUC‐1, UMUC‐3, T24, 5637, A375, and HeLa cells were selected to validate the protein expression levels of PD‐L1, where SV‐HUC‐1, UMUC‐3, T24 and 5637 were bladder cell lines.

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PMC9429973

Other causes of death included cardiac disorders (n = 1), neoplasms (n = 4; acute myeloid leukemia, metastatic urothelial carcinoma of the kidney, metastatic malignant neoplasm of the lung and non-small cell lung carcinoma) and respiratory disorders (n = 1).

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PMC2944824

When apoptosis was induced with the mitochondrial stressor staurosporine and endoplasmic reticulum stressor (ER) tunicamycin , forced expression of Hr resulted in higher cell viability in COS cells (supplementary data figure S1).

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PMC6267596

a & b) Cell cycle analyses of U2932 & VAL cells respectively after treatment with 50nM alisertib for 4 days followed by recovery in the absence of drug up to 30-days shows that DLBCL cells establish a diploid 2n-near aneuploid population. (

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PMC5025404

The transfection efficiency was evaluated visually using a CKX41 microscope (Olympus, Japan).

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PMC11283030

What's more, we also found that provision of acetyl-CoA, the product of ACLY, could activate AKT/mTORC1 pathway in ACLY knockdown ccRCC cells, which suggests the potential mechanism that ACLY controls acetyl-CoA level to regulate AKT/mTORC1 pathway in ccRCC.

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PMC9429973

Methods: This study involved 197 Chinese ITP pediatric patients (discovery cohort) and 220 healthy controls.

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PMC11442172

They found that 3D spheroids cultured in Plasmax had a metabolic profile closest to that of the tumors, suggesting that 3D culture in a physiological medium better approximates the tumor’s metabolic phenotype (27).

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PMC9429973

Thirty-one (97%) patients experienced ≥1 AE, 25 (78%) had Grade ≥3 AEs, and 6 (19%) had serious AEs.

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PMC11705630

When the confluence reached 80-90%, the wound was created by scratching with 10 µl pipette tip.

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PMC7504302

Consistent with previous reports, the EMT gene signature was able to define distinct molecular subgroups of MPMs.

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PMC9847912

GSK232 or water for the no-drug controls was added (22 μl per well, 4 wells per drug concentration), and the plates were incubated at 37°C in 5% CO2 for 60 min.

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PMC11240448

Nevertheless, a minor amount of non-zero, non-diagonal elements in the confusion matrix was present for DPDLB, indicating slight inaccuracy in the classification of BC subtype cell states, brought about by the low data dimensionality.

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PMC10073922

The formation of Sur-P-NDRG2 was validated using colony PCR and sequencing.

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PMC11407042

Gently moving the dishes or wrapping the plate and then observing the cell distribution under the inverted microscope before incubation would help to avoid cell clusters.

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PMC11413393

RBP: RNA-binding protein; aDMA: asymmetric dimethylation; Me: methyl group.

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PMC11489175

This feature renders AMSH an interesting target for therapeutic intervention 65.

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PMC10114490

Values correspond to the average of at least two experiments with three replicates each. *

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PMC9786247

Thereafter, the GE numbers of all the assessed strains significantly increased by two to four orders of magnitude until 14 d p.i.,

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PMC11453018

Among all the parameters, only glucose showed a slight upregulation in the iP300w-treated group.

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PMC11578343

Once a resist template of the electrodes and contact pads were patterned onto a glass substrate, electron‐gun evaporation was used to deposit a thin film of 75/250/250 Å Ti (titanium)/Pt/Au and a lift‐off was performed to remove the excess metal.

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PMC11720808

To further verify the effect of SCU on OS cell proliferation, we conducted an EdU assay.

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PMC11804588

However, the resolution of this approach is constrained by the uneven distribution of GpC sites within the TF binding sites as well as the endogenous cytosine methylation.

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PMC11544122

Cells were treated with vehicle or CXCL12 (50 nM) for 30 min at 37 °C and FLAG-CXCR4 endocytosis was measured by ELISA.

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PMC8270637

Its role is to be dephosphorylated by calcineurin (CaN) and then translocate to the nucleus to regulate gene transcription.

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PMC11190538

Some chemotherapeutic medicines cause apoptosis in target cells by generating free radicals; antioxidants, on the other hand, can scavenge these radical molecules and limit the side effects of therapeutic agents .

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PMC11697703

In particular, the molecular mechanisms of dendritic development in specific cortical projection neuron subtypes represent the least understood aspect of cortical projection neuron development.

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PMC11534035

However, when the concentration of G1 was increased to 2.5 μM, the reduction in colonies was drastic, and on statistical analysis, became significant (M=3.222±1.392 colonies vs. control; p<0.0001).

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PMC11656048

MG63 and 143B cells were treated with shikonin (1.5 uM) in the presence or absence of Fer-1 (10 uM) for 24 h, and CCK-8 results showed that Fer-1 could partially reverse shikonin induced reduction in OS cell viability (Figures 2A, B).

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PMC9429973

We obtained primary CLL cells from patients before and during treatment with ofatumumab on a clinical study conducted at the NIH (NCT01145209) and used lymphoma cell lines HBL2 (Mantle Cell Lymphoma) and SUDHL6 (Diffuse Large B cell Lymphoma) to test in vitro and in vivo efficacy of anti-C3d antibodies.

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PMC9351137

The observed relocation of CRS to the mitotic apparatus during cell cycle progression may be interpreted as result of passive accumulation of proteins to be disposed of.

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PMC9429973

However, TET2 LOF is not limited to leukemias.

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PMC10669966

Interestingly, a highly homologous pathway, the insulin signaling pathway, was observed as the second-most-upregulated pathway in our analysis, after the phospholipase C-mediated cascade.

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PMC11621493

In brief, two-day-old neonatal mice (WT or Pla2g4d-deficient) were sacrificed via decapitation and the skin was peeled off using forceps and scissors.

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PMC9429973

The median number of bleeding episodes in the past 5 years was 0 (0-1).

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PMC11098378

N-terminal GFP-IpaH4 was constructed through Gateway cloning into pEGFP-C2 (for mammalian expression), then PCR amplified using primers introducing SacII/PacI sites and cloned into pDGOpIE2 (for insect cell expression).

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PMC9429973

At C2D1 EOI, most responders had a reduction in sBCMA relative to baseline, with the pts who achieved sCR having the greatest decrease (median: –92.10%).

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