OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11026382	The marginal distribution of epistatic effects is shown along each axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "marginal", "distribution", "of", "epistatic", "effects", "is", "shown", "along", ...
PMC11805741	While the pigment bore low toxicity with IC50 of 52.24 µg /ml towards the non- cancerous human fibroblast cell line (Barretto and Vootla 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10734950	All utilized cell lines used in this study were acquired from the American Type Culture Collection (ATCC, Manassas, VA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9250505	After cooling, sections were immersed in a solution of 3% hydrogen peroxide for 10 min in order to reduce endogenous peroxidase activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	E. Marín Sánchez, E. Fernandes, J. López Marín, F. Tarín, L. Hernandez Mateo Hospital General Universitario Alicante, Alicante, Spain; Hematology, Hospital General Universitario Alicante, Alicante, Spain Background: aTTP is a life threatening disease mediated by auto-antibodies directed against ADAMTS13, with reduced a...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	Selection was then treated with 2 µg/ml puromycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Selection", "was", "then", "treated", "with", "2", "µg/ml", "puromycin", "." ] } ]
PMC11519583	Among the Wnt family genes examined, Wnt11 expression decreased following Ctx injection but was sustained at a basal level in glycerol-injected TA muscles (Supplementary Fig. 9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	Trypsin (Promega) was then added at the same enzyme:protein ratio and digestion was performed overnight at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Trypsin...
PMC11679033	These findings underscore the complexity of CBD-CIT interactions at physiological concentrations, highlighting the potential for selective cytotoxic effects based on cellular context and compound combinations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11737091	The constructed pLKO.1-DBF4-shRNA lentivirus was subsequently used to transfect A498 and 786-O ccRCC cells via Lipofectamine™ 2000 (Invitrogen) with polybrene (8 mg/mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC10870498	Overexpression of SIRT7 enhanced the protein stability of KIF23 in HEK-293T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "Overexpression", "of", "SIRT7", "enhanced", "the", "protein", "...
PMC11754291	All three wavelengths were able to increase pigmentation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "three", "wavelengths", "were", "able", "to", "increase", "pigmentation", "." ] } ]
PMC11718274	The activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) was measured following the protocols established by Nishikimi et al.and Aebi respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377	The resulted mix contains the cDNA corresponding to the 5000 ng of total RNA included in the reaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulted", "mix", "contains", "...
PMC9429973	Other AEs were: urinary infections not requiring admissión (n=2), cytomegalovirus viremia (n=1), herpes simplex virus reactivation (n=1), deep venous thromboembolism (n=1), diarrhea (n=1), skin atrophy (n=2) and folliculitis (n=2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11438317	As a result, we developed LYP mutants in key catalytic amino acids: D195A (DA), C227S (CS), and the double mutant D195A/C227S (DACS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597	p‐values were calculated with unpaired two‐sided Student t‐test or one‐way ANOVA test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p‐values", "were", "calculated", "with", "unpaired", "two‐sided", "Student", "t‐test",...
PMC11617590	Nuclear and cytoplasmic extraction post‐exposure prophylaxis (NE‐PEP) reagents kit used to separate cytoplasm and nucleus was purchased from Thermo Fisher Scientific (Bonn, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Sixty-five pts (85%) received Hyper-CVAD based induction therapy [HCVAD-based (n=51); mini-CVD-based (n=14)] and 11 (15%) received augmented BFM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890307	In vivo, normal cells carefully control the production and release of growth-promoting signals, ensuring cell growth and division according to tissue homeostasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9473868	BAI is a traditional Chinese herbal medicine with anti-inflammatory and antioxidant activities .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BAI", "is", "a", "traditional", "Chinese", "herbal", "medicine", "with", "anti-i...
PMC11674891	Comparative and survival analyses were conducted using LUNG CANCER EXPLORER (https://lce.biohpc.swmed.edu/lungcancer/index.php) (accessed on 18 December 2024) and the Kaplan–Meier Plotter (https://kmplot.com/analysis/) (accessed on 18 December 2024) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792090	IHC staining of human CD45 in tumors to assess CAR-T cell infiltration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IHC", "staining", "of", "human", "CD45", "in", "tumors", "to", "assess", "...
PMC9504875	TRIM25 binding to RIG-I is necessary for RIG-I ubiquitination, so it was hypothesized that N protein inhibits TRIM25-mediated RIG-I ubiquitination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TRIM25", "binding", ...
PMC11021472	All primers used are listed in Supplemental Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "primers", "used", "are", "listed", "in", "Supplemental", "Table", "1", "." ] } ]
PMC11122631	The electronic and thermal free energies of each conformer were summed, and the Boltzmann distribution ratio was computed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "electronic", "and", "therm...
PMC11765678	This would further clarify the clinical potentials for combining ferroptosis inducers with chemotherapeutic agents as novel combination therapies to overcome drug resistance in patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10578720	Treatment condition at the HBV titers of 0 IU/mL was used as a control group (CON).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "condition", "at", "the", ...
PMC11529598	C. Invasion ability of miR-3154 sponge U251 cells and control U251 cells was measured using invasion assay. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "Invasion", "ability", ...
PMC11711127	Again, tolDCs were thought to propagate FOXP3+Ag-specific Tregs to establish a tolerance that was durable against inflammatory stimuli (112113).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Again", ",",...
PMC11650848	Reduced DNA methylation in the DKO- and Aza-treated cell lines allow amplification of exons 4 and 5 including the canonical RefSeq transcript.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reduced", "D...
PMC9848491	ssGSEA, single sample gene set enrichment analysis; aDCs, activated dendritic cells; iDCs, immature dendritic cells; NK, natural killer; pDCs, plasmacytoid dendritic cells; Tfh, T follicularhelper; Th1, T helper type 1; Th2, T helper type 2; TIL, tumor-infiltrating lymphocyte; Treg, T regulatory cell; APC, antigen-pres...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11451940	Finally, the cells were analysed using the BD FACSVerse flow cytometer (Becton Dickinson, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "cells", "were",...
PMC10490530	The BL gene from the wild mushroom species Neonothopanus nambi was recently discovered by identifying the intermediates of the luciferin biosynthetic pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "BL", ...
PMC7802142	n ≥ 3; P < 0.05, **P < 0.001 versus the 293-NVgroups (c) or PBS groups (d) by One-way ANOVA miR-100 enriched in ReN-NV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9105697	Both captures were incubated for 4 h at 65 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "captures", "were", "incubated", "for", "4", "h", "at", "65", "°", "C", ...
PMC11674891	Despite advances in surgical intervention, radiotherapy, and multimodal treatments, lung cancer incidence continues to rise, and GRPR overexpression is found in 68% of adenocarcinoma cases in NSCLC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	To validate this selective activity, we performed a colony formation assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "validate", "this", "selective", "activity", ",", "we", "performed", "a", ...
PMC11629461	Kit for plasmid extraction (#DP118) was bought from TianGen Biochemicals (Beijing, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kit", "for", "plasmid", "extraction", ...
PMC11697189	Patients in the high-risk group might benefit more from immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "in", "the", "high-risk", "group", "might", "benefit", "more", "from", "immunotherapy...
PMC11409031	Shows the correlation between risk scores and various clinical features. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shows", "the", "correlation", "between", "risk", "scores", "and", "various", "clinical", ...
PMC11258145	With the increase in the concentration of curcumin, an increase in the value of this parameter was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "increase", "in", ...
PMC11699178	SK-OV-3 cells were cultured in RPMI-1640 medium (Gibco, Cat.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SK-OV-3", "cells", "were", "cultured", "in", "RPMI-1640", "medium", "(", "Gibco", ...
PMC8414691	WCE, whole cell extract.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "WCE", ",", "whole", "cell", "extract", "." ] } ]
PMC11266100	Images were taken with IVIS Spectrum device and analyzed by Living Image software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "taken", "with", "IVIS", "Spectrum", "device", "and", ...
PMC9503685	These dilutions were plated on TSA, incubated overnight at 37 °C, and colonies were counted the next day to determine cfu/mL .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	To test if targeting the interaction of BIM with BCL2 will induce an apoptotic effect when combined with EHT1610, we treated four KMT2A-R ALL cell lines with increasing concentrations of EHT1610 and the BCL2 inhibitor venetoclax.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC9429973	Bortezomib-based regimens have been recommended as first-line therapy of MM with RI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bortezomib-based", "regimens", "have", "been", "recommended", "as", "first-line", "the...
PMC10976516	Severe tumor regression and inhibition of Tregs and increased CD8+/Treg ratios; increased T cell activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Severe", "tumor", "regression", "and", "inhibition", "...
PMC10551595	p < 0.05, p < 0.01, p < 0.001, ***p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11734514	The expression of PTEN, Akt, p-Akt, p-mTOR, and STAT-3 proteins held significance as they influenced the phenomena that occurred in A549 cells (Figure 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC10873328	The high-risk group had higher mortality compared with low-risk group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "high-risk", "group", "had", "higher", "mortality", "compared", "with", "low-risk", "group...
PMC10170482	Additionally, we found that mechanically driven effects on cellular function are the most profound on the seventh day of culturing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", ...
PMC11322866	Cells were collected, and the cell lysates were subjected to western blot analysis with the indicated antibodies. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "collected", ",",...
PMC7519871	This combination is a less toxic option in the treatment of cervical cancer, especially in case of chemoresistance to cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "combination", ...
PMC11434983	Positively charged lipophilic compounds with PPh3 are well known for their ability to target mitochondria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Positively", "charged", "lipophilic", "compounds", "with", "PPh3"...
PMC9429973	Recently, flow cytometry (FC) evaluation of CSF was shown to provide more reliable results and to predict relapse risk (de Haas et al., 2021, Thastrup et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	Similarly, intermittent hypoxia linked to OSA plays a major role in the pathophysiology of metabolic syndrome in terms of sympathetic activation, systemic inflammation, impaired glucose and lipid metabolism, and endothelial dysfunction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665584	Identifying the molecular factors that distinguish the 2 populations of keratinocytes has been a subject of ongoing investigation with the goal of applying insights to the design of novel therapeutic strategies for acute and chronic wounds (4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10545062	As a result, this subalgorithm triggered micro boluses in an effort to improve UOP, support hemodynamics, and lessen vasopressor requirements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", ...
PMC9429973	A data intensive web-based dashboard platform is also provided for healthcare professionals, providing real-time analytics, enabling a better view of collected PROs and other relevant information on patients’ health status.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10914904	The critical nucleotides for OAS1 recognition are encircled in red.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "critical", "nucleotides", "for", "OAS1", "recognition", "are", "encircled", "in", "red", ...
PMC11739504	In this study, histone K (lysine) acetyltransferase 2 B (Kat2b) was identified as a novel regulator of primary cilia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9895440	First, we observed that Snx9 itself and Il2ra (encoding CD25) were downregulated among multiple clusters, confirming our ex vivo findings with human T cells (Fig. 4g, Supplementary Fig. 9d, Supplementary Data 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	n.s.,	[ { "tags": [ "O", "O", "O" ], "tokens": [ "n.s", ".", "," ] } ]
PMC8806312	The results showed that the high-risk groups were positively associated with the cell cycle and negatively related to chemokine and B cell receptor signaling pathways, cell adhesion molecules (CAMs), and cytokine-cytokine receptor (CCR) interactions (Figure 6 and Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Overall response rate in the efficacy evaluable population was 56% (9/16), with 4 (25%) pts achieving a complete response (CR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614	Bonferroni post-hoc adjustment was used for the reported adjusted p-values ≤ 0.05 for significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bonferroni", "post-hoc", "adjustment", "was", "used", "for", "the", ...
PMC10729469	Undivided CFSE+ Tresp (green peaks), divided CFSE + Tresp (red peaks), Treg cells (blue peaks) Characterization of TCRAβ-Treg immunosuppressive function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We did not observe a significant difference in terms of infections in the two randomized arms; infections grade >2 or death were reported in 35 (43.7%) patients in arm A and in 34 (41.5%) patients in arm B [relative risk RR=1.05, confidence interval (CI)95%=0.76-1.4].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745823	Functional assays demonstrate that RIT1 facilitates the aggressiveness of glioma cells by activating the PI3K/AKT signalling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "assays", "demonstrate", "that", "RIT1", ...
PMC11730311	Lysine (K), glutamic acid (E), phenylalanine (F), serine (S), and alanine (A) were applied as substitutions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	no. M3949) and luteolin (Cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "M3949", ")", "and", "luteolin", "(", "Cat", "." ] } ]
PMC11216402	PCA of gene expression profiles is consistent with PCA from ATAC-seq. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "of", "gene", "expression", "profiles", "is", "consistent", "with", "PCA",...
PMC11541241	The Rheb‐activating mutations showed impaired infection ability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Rheb‐activating", "mutations", "showed", "impaired", "infection", "ability", "." ] } ]
PMC11420784	Significance is indicated by the P value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significance", "is", "indicated", "by", "the", "P", "value", "." ] } ]
PMC8526701	Therefore, it is very important to understand the molecular mechanism underlying GIST malignancy to develop novel therapeutic options.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "it", "is", ...
PMC10589262	These findings indicate that ER stress induction alone is not sufficient to effectively suppress GIST growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "indicate", "that", "ER", "stress"...
PMC9275501	PSN38@TPL-nsa showed strong antitumor effect and reshaped tumor microenvironment in cancer-related fibroblasts-rich peritoneal disseminated tumor and patient-derived xenograft model of gastric cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PSN38@TPL-nsa", ...
PMC11367146	Finally, the docking visualisation was performed using Autodock Vina.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "docking", "visualisation", "was", "performed", "using", "Autodock", "Vina...
PMC9429973	The best-fit model from each method was a candidate for overall best fit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "best-fit", "model", "from", "each", "method", "was", "a", "can...
PMC10291556	This suggests that the mechanism underlying the biological action of these complexes is at least partially different from that of cisplatin, allowing the compounds to overcome the resistance mechanisms acting in the case of cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Remaining pts (n=160) were in continuous complete remission (CCR) after a median follow-up of 1053 (479-1934) days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9275501	Gao et al. (2017a) prepared a new type of pH-sensitive prodrug nanoparticles by synthesizing the self-assembly of amphiphilic macromolecular prodrugs for selective co-delivery of DOX and CUR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: In our analysis, the ORR obtained have been greater than 50%, maintaining this response at one year of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10253973	Excitation takes place at around 420 nm and the molecule enters a triplet excitation state (MLCT) in oxidized acetonitrile with a lifetime of 200 ns and 76 µs in unoxidized acetonitrile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739484	Subsequent validation across multiple cohorts confirmed significant (p-value < 0.05) elevated MMP expression levels in SKCM tissues, particularly in advanced disease stages, further emphasizing their role in tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11021472	Moreover, being able to generate a monoclonal cell line with this deletion argues against an important role of the miR-150 binding site region in circZDHHC11 and possibly any of the other ZDHHC11 transcripts in supporting growth of BL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	7 + 3 with fractionated GO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7", "+", "3", "with", "fractionated", "GO", "." ] } ]
PMC6190245	As F. gummosa is a rich source of natural antioxidants (Nabavi et al., 2012 ▶), we think that this mechanism may play a key role in the radiosensitizing activity of F. gummosa observed in this experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676674	On the other hand, C. monspeliensis extract-treated cells at the lowest concentration of 50 μg/mL in the presence of MMC showed a significantly lower micronuclei frequency by almost 34% compared to MMC control cells, thus indicating a protective effect against MMC-mediated genotoxicity exerted by C. monspeliensis extra...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10745221	The whole cell extract was separated with 35 μL in each well on a 4–20% (unless otherwise mentioned) ExpressPlus PAGE gel (GenScript catalog #M42010) at 140V for 1 hour using a BioRad PowerPac 300 electrophoresis Power supply with Tris-MOPS-SDS running buffer (GenScript Tris-MOPS-SDS Running Buffer Powder; 50 mM Tris B...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11237030	Briefly, NUNC Maxisorp 96-well Immuno plates (Thermo Scientific) were coated overnight at 4 ℃ with 2 µg/ml of capture antibody anti-AQP5 (Abcam) in 1× PBS, followed by blocking with 3% BSA/1× PBS for 2 h at RT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The most common nonhematologic AE was CRS in 72% patients (grade 3, 0.6%; no grade 4/5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most"...
PMC11538390	MCS-9.7-lacZ transgenic reporter constructs were generated with the risk and non-risk alleles of rs570516915 on the Finnish haplotype background with a mouse Shh promoter (Supplementary Methods).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7812570	The plasmid encoding DSP1-7 and 293FT cells stably expressing CXCR4/CCR5/DSP8–11 were kindly gifted by Zene Matsuda at the Institute of Medical Science of the University of Tokyo (Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574271	G The tumor growth was assessed periodically and represented in a line chart.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "The", "tumor", "growth", "was", "assessed", "periodically", "and", ...
PMC11637716	Due to additional recurrent cardiac decompensation, treatment with catecholamines and diuretics was given but did not lead to sustained improvement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "addi...
PMC9429973	Results: In total, about 52.1 million RNA-chromatin interactions were identified out of deep sequencing of four iMARGI libraries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "In", "...
PMC11786704	In the field of diabetic wound treatment, the search for effective treatment methods has always been crucial .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "field", "of", "diabetic",...

PMC11026382

The marginal distribution of epistatic effects is shown along each axis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "marginal", "distribution", "of", "epistatic", "effects", "is", "shown", "along", ...

PMC11805741

While the pigment bore low toxicity with IC50 of 52.24 µg /ml towards the non- cancerous human fibroblast cell line (Barretto and Vootla 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC10734950

All utilized cell lines used in this study were acquired from the American Type Culture Collection (ATCC, Manassas, VA, USA).

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PMC9250505

After cooling, sections were immersed in a solution of 3% hydrogen peroxide for 10 min in order to reduce endogenous peroxidase activity.

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PMC9429973

E. Marín Sánchez, E. Fernandes, J. López Marín, F. Tarín, L. Hernandez Mateo Hospital General Universitario Alicante, Alicante, Spain; Hematology, Hospital General Universitario Alicante, Alicante, Spain Background: aTTP is a life threatening disease mediated by auto-antibodies directed against ADAMTS13, with reduced a...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11794568

Selection was then treated with 2 µg/ml puromycin.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Selection", "was", "then", "treated", "with", "2", "µg/ml", "puromycin", "." ] } ]

PMC11519583

Among the Wnt family genes examined, Wnt11 expression decreased following Ctx injection but was sustained at a basal level in glycerol-injected TA muscles (Supplementary Fig. 9).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11697065

Trypsin (Promega) was then added at the same enzyme:protein ratio and digestion was performed overnight at 37°C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Trypsin...

PMC11679033

These findings underscore the complexity of CBD-CIT interactions at physiological concentrations, highlighting the potential for selective cytotoxic effects based on cellular context and compound combinations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11737091

The constructed pLKO.1-DBF4-shRNA lentivirus was subsequently used to transfect A498 and 786-O ccRCC cells via Lipofectamine™ 2000 (Invitrogen) with polybrene (8 mg/mL).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...

PMC10870498

Overexpression of SIRT7 enhanced the protein stability of KIF23 in HEK-293T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "Overexpression", "of", "SIRT7", "enhanced", "the", "protein", "...

PMC11754291

All three wavelengths were able to increase pigmentation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "three", "wavelengths", "were", "able", "to", "increase", "pigmentation", "." ] } ]

PMC11718274

The activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) was measured following the protocols established by Nishikimi et al.and Aebi respectively.

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PMC11534377

The resulted mix contains the cDNA corresponding to the 5000 ng of total RNA included in the reaction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulted", "mix", "contains", "...

PMC9429973

Other AEs were: urinary infections not requiring admissión (n=2), cytomegalovirus viremia (n=1), herpes simplex virus reactivation (n=1), deep venous thromboembolism (n=1), diarrhea (n=1), skin atrophy (n=2) and folliculitis (n=2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11438317

As a result, we developed LYP mutants in key catalytic amino acids: D195A (DA), C227S (CS), and the double mutant D195A/C227S (DACS).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11789597

p‐values were calculated with unpaired two‐sided Student t‐test or one‐way ANOVA test.

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PMC11617590

Nuclear and cytoplasmic extraction post‐exposure prophylaxis (NE‐PEP) reagents kit used to separate cytoplasm and nucleus was purchased from Thermo Fisher Scientific (Bonn, Germany).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Sixty-five pts (85%) received Hyper-CVAD based induction therapy [HCVAD-based (n=51); mini-CVD-based (n=14)] and 11 (15%) received augmented BFM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10890307

In vivo, normal cells carefully control the production and release of growth-promoting signals, ensuring cell growth and division according to tissue homeostasis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9473868

BAI is a traditional Chinese herbal medicine with anti-inflammatory and antioxidant activities .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BAI", "is", "a", "traditional", "Chinese", "herbal", "medicine", "with", "anti-i...

PMC11674891

Comparative and survival analyses were conducted using LUNG CANCER EXPLORER (https://lce.biohpc.swmed.edu/lungcancer/index.php) (accessed on 18 December 2024) and the Kaplan–Meier Plotter (https://kmplot.com/analysis/) (accessed on 18 December 2024) .

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PMC11792090

IHC staining of human CD45 in tumors to assess CAR-T cell infiltration.

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PMC9504875

TRIM25 binding to RIG-I is necessary for RIG-I ubiquitination, so it was hypothesized that N protein inhibits TRIM25-mediated RIG-I ubiquitination.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TRIM25", "binding", ...

PMC11021472

All primers used are listed in Supplemental Table 1.

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PMC11122631

The electronic and thermal free energies of each conformer were summed, and the Boltzmann distribution ratio was computed.

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PMC11765678

This would further clarify the clinical potentials for combining ferroptosis inducers with chemotherapeutic agents as novel combination therapies to overcome drug resistance in patients.

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PMC10578720

Treatment condition at the HBV titers of 0 IU/mL was used as a control group (CON).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "condition", "at", "the", ...

PMC11529598

C. Invasion ability of miR-3154 sponge U251 cells and control U251 cells was measured using invasion assay. *

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PMC11711127

Again, tolDCs were thought to propagate FOXP3+Ag-specific Tregs to establish a tolerance that was durable against inflammatory stimuli (112113).

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PMC11650848

Reduced DNA methylation in the DKO- and Aza-treated cell lines allow amplification of exons 4 and 5 including the canonical RefSeq transcript.

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PMC9848491

ssGSEA, single sample gene set enrichment analysis; aDCs, activated dendritic cells; iDCs, immature dendritic cells; NK, natural killer; pDCs, plasmacytoid dendritic cells; Tfh, T follicularhelper; Th1, T helper type 1; Th2, T helper type 2; TIL, tumor-infiltrating lymphocyte; Treg, T regulatory cell; APC, antigen-pres...

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PMC11451940

Finally, the cells were analysed using the BD FACSVerse flow cytometer (Becton Dickinson, USA).

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PMC10490530

The BL gene from the wild mushroom species Neonothopanus nambi was recently discovered by identifying the intermediates of the luciferin biosynthetic pathway .

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PMC7802142

n ≥ 3; *P < 0.05, ***P < 0.001 versus the 293-NVgroups (c) or PBS groups (d) by One-way ANOVA miR-100 enriched in ReN-NV.

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PMC9105697

Both captures were incubated for 4 h at 65 °C.

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PMC11674891

Despite advances in surgical intervention, radiotherapy, and multimodal treatments, lung cancer incidence continues to rise, and GRPR overexpression is found in 68% of adenocarcinoma cases in NSCLC .

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PMC11790599

To validate this selective activity, we performed a colony formation assay.

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PMC11629461

Kit for plasmid extraction (#DP118) was bought from TianGen Biochemicals (Beijing, China).

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PMC11697189

Patients in the high-risk group might benefit more from immunotherapy.

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PMC11409031

Shows the correlation between risk scores and various clinical features. (

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PMC11258145

With the increase in the concentration of curcumin, an increase in the value of this parameter was observed.

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PMC11699178

SK-OV-3 cells were cultured in RPMI-1640 medium (Gibco, Cat.

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PMC8414691

WCE, whole cell extract.

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PMC11266100

Images were taken with IVIS Spectrum device and analyzed by Living Image software.

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PMC9503685

These dilutions were plated on TSA, incubated overnight at 37 °C, and colonies were counted the next day to determine cfu/mL .

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PMC9429973

To test if targeting the interaction of BIM with BCL2 will induce an apoptotic effect when combined with EHT1610, we treated four KMT2A-R ALL cell lines with increasing concentrations of EHT1610 and the BCL2 inhibitor venetoclax.

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PMC9429973

Bortezomib-based regimens have been recommended as first-line therapy of MM with RI.

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PMC10976516

Severe tumor regression and inhibition of Tregs and increased CD8+/Treg ratios; increased T cell activity.

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PMC10551595

p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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PMC11734514

The expression of PTEN, Akt, p-Akt, p-mTOR, and STAT-3 proteins held significance as they influenced the phenomena that occurred in A549 cells (Figure 3A).

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PMC10873328

The high-risk group had higher mortality compared with low-risk group.

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PMC10170482

Additionally, we found that mechanically driven effects on cellular function are the most profound on the seventh day of culturing.

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PMC11322866

Cells were collected, and the cell lysates were subjected to western blot analysis with the indicated antibodies. (

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PMC7519871

This combination is a less toxic option in the treatment of cervical cancer, especially in case of chemoresistance to cisplatin.

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PMC11434983

Positively charged lipophilic compounds with PPh3 are well known for their ability to target mitochondria.

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PMC9429973

Recently, flow cytometry (FC) evaluation of CSF was shown to provide more reliable results and to predict relapse risk (de Haas et al., 2021, Thastrup et al., 2020).

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PMC10530622

Similarly, intermittent hypoxia linked to OSA plays a major role in the pathophysiology of metabolic syndrome in terms of sympathetic activation, systemic inflammation, impaired glucose and lipid metabolism, and endothelial dysfunction .

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PMC11665584

Identifying the molecular factors that distinguish the 2 populations of keratinocytes has been a subject of ongoing investigation with the goal of applying insights to the design of novel therapeutic strategies for acute and chronic wounds (4).

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PMC10545062

As a result, this subalgorithm triggered micro boluses in an effort to improve UOP, support hemodynamics, and lessen vasopressor requirements.

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PMC9429973

A data intensive web-based dashboard platform is also provided for healthcare professionals, providing real-time analytics, enabling a better view of collected PROs and other relevant information on patients’ health status.

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PMC10914904

The critical nucleotides for OAS1 recognition are encircled in red.

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PMC11739504

In this study, histone K (lysine) acetyltransferase 2 B (Kat2b) was identified as a novel regulator of primary cilia.

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PMC9895440

First, we observed that Snx9 itself and Il2ra (encoding CD25) were downregulated among multiple clusters, confirming our ex vivo findings with human T cells (Fig. 4g, Supplementary Fig. 9d, Supplementary Data 5).

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PMC11095939

n.s.,

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PMC8806312

The results showed that the high-risk groups were positively associated with the cell cycle and negatively related to chemokine and B cell receptor signaling pathways, cell adhesion molecules (CAMs), and cytokine-cytokine receptor (CCR) interactions (Figure 6 and Table 2).

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PMC9429973

Overall response rate in the efficacy evaluable population was 56% (9/16), with 4 (25%) pts achieving a complete response (CR).

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PMC11731614

Bonferroni post-hoc adjustment was used for the reported adjusted p-values ≤ 0.05 for significance.

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PMC10729469

Undivided CFSE+ Tresp (green peaks), divided CFSE + Tresp (red peaks), Treg cells (blue peaks) Characterization of TCRAβ-Treg immunosuppressive function.

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PMC9429973

We did not observe a significant difference in terms of infections in the two randomized arms; infections grade >2 or death were reported in 35 (43.7%) patients in arm A and in 34 (41.5%) patients in arm B [relative risk RR=1.05, confidence interval (CI)95%=0.76-1.4].

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PMC11745823

Functional assays demonstrate that RIT1 facilitates the aggressiveness of glioma cells by activating the PI3K/AKT signalling.

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PMC11730311

Lysine (K), glutamic acid (E), phenylalanine (F), serine (S), and alanine (A) were applied as substitutions.

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PMC9596868

no. M3949) and luteolin (Cat.

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PMC11216402

PCA of gene expression profiles is consistent with PCA from ATAC-seq. (

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PMC11541241

The Rheb‐activating mutations showed impaired infection ability.

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PMC11420784

Significance is indicated by the P value.

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PMC8526701

Therefore, it is very important to understand the molecular mechanism underlying GIST malignancy to develop novel therapeutic options.

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PMC10589262

These findings indicate that ER stress induction alone is not sufficient to effectively suppress GIST growth.

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PMC9275501

PSN38@TPL-nsa showed strong antitumor effect and reshaped tumor microenvironment in cancer-related fibroblasts-rich peritoneal disseminated tumor and patient-derived xenograft model of gastric cancer.

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PMC11367146

Finally, the docking visualisation was performed using Autodock Vina.

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PMC9429973

The best-fit model from each method was a candidate for overall best fit.

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PMC10291556

This suggests that the mechanism underlying the biological action of these complexes is at least partially different from that of cisplatin, allowing the compounds to overcome the resistance mechanisms acting in the case of cisplatin.

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PMC9429973

Remaining pts (n=160) were in continuous complete remission (CCR) after a median follow-up of 1053 (479-1934) days.

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PMC9275501

Gao et al. (2017a) prepared a new type of pH-sensitive prodrug nanoparticles by synthesizing the self-assembly of amphiphilic macromolecular prodrugs for selective co-delivery of DOX and CUR.

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PMC9429973

Summary/Conclusion: In our analysis, the ORR obtained have been greater than 50%, maintaining this response at one year of therapy.

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PMC10253973

Excitation takes place at around 420 nm and the molecule enters a triplet excitation state (MLCT) in oxidized acetonitrile with a lifetime of 200 ns and 76 µs in unoxidized acetonitrile.

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PMC11739484

Subsequent validation across multiple cohorts confirmed significant (p-value < 0.05) elevated MMP expression levels in SKCM tissues, particularly in advanced disease stages, further emphasizing their role in tumor progression.

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PMC11021472

Moreover, being able to generate a monoclonal cell line with this deletion argues against an important role of the miR-150 binding site region in circZDHHC11 and possibly any of the other ZDHHC11 transcripts in supporting growth of BL cells.

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PMC9429973

7 + 3 with fractionated GO.

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PMC6190245

As F. gummosa is a rich source of natural antioxidants (Nabavi et al., 2012 ▶), we think that this mechanism may play a key role in the radiosensitizing activity of F. gummosa observed in this experiment.

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PMC11676674

On the other hand, C. monspeliensis extract-treated cells at the lowest concentration of 50 μg/mL in the presence of MMC showed a significantly lower micronuclei frequency by almost 34% compared to MMC control cells, thus indicating a protective effect against MMC-mediated genotoxicity exerted by C. monspeliensis extra...

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PMC10745221

The whole cell extract was separated with 35 μL in each well on a 4–20% (unless otherwise mentioned) ExpressPlus PAGE gel (GenScript catalog #M42010) at 140V for 1 hour using a BioRad PowerPac 300 electrophoresis Power supply with Tris-MOPS-SDS running buffer (GenScript Tris-MOPS-SDS Running Buffer Powder; 50 mM Tris B...

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PMC11237030

Briefly, NUNC Maxisorp 96-well Immuno plates (Thermo Scientific) were coated overnight at 4 ℃ with 2 µg/ml of capture antibody anti-AQP5 (Abcam) in 1× PBS, followed by blocking with 3% BSA/1× PBS for 2 h at RT.

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PMC9429973

The most common nonhematologic AE was CRS in 72% patients (grade 3, 0.6%; no grade 4/5).

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PMC11538390

MCS-9.7-lacZ transgenic reporter constructs were generated with the risk and non-risk alleles of rs570516915 on the Finnish haplotype background with a mouse Shh promoter (Supplementary Methods).

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PMC7812570

The plasmid encoding DSP1-7 and 293FT cells stably expressing CXCR4/CCR5/DSP8–11 were kindly gifted by Zene Matsuda at the Institute of Medical Science of the University of Tokyo (Tokyo, Japan).

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PMC11574271

G The tumor growth was assessed periodically and represented in a line chart.

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PMC11637716

Due to additional recurrent cardiac decompensation, treatment with catecholamines and diuretics was given but did not lead to sustained improvement.

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PMC9429973

Results: In total, about 52.1 million RNA-chromatin interactions were identified out of deep sequencing of four iMARGI libraries.

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PMC11786704

In the field of diabetic wound treatment, the search for effective treatment methods has always been crucial .

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