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PMC11806818
B The synthesis process of MoS2-MIL-101(Fe) and schematic diagram of exosome detection mechanism of the proposed method.
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PMC11700523
IS accumulation was observed in the damaged tubules in the 5/6 Nx rat model.
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PMC6835428
OCs of epithelial origin have been further subdivided into (Figure 1): type I tumors, which contain well-differentiated cells (such as low grade serous carcinoma and endometrioid carcinoma) and are characterized by low malignity; type II tumors, which are rather aggressive and arise directly from the epithelial tissue of the organ without going through a precancerous phase (typically represented by the high-grade serous ovarian carcinomas—HGSOCs) .
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PMC11394227
It was hypothesized that this was due to the rapid folding of disulfide bonds in CHO-PAb-QS cells, resulting in fewer unfolded and misfolded proteins.
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PMC6133382
However, the ultimate utility of this cell line will require characterization of stable cell lines with transfected envelope proteins in which the genetic stability of the transgene as well as the quality and yield of the final product is determined.
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PMC7369657
CQDs induced cytotoxicity in the 143B cell line through the mitochondrial apoptotic signaling pathway.
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PMC11055323
The SW982 cells stably expressed empty vector, wild-type SS18-SSX1 and its mutants were seeded at 1000 cells per well in six-well plates.
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PMC11763111
To account for the short lifespan of NK cells compared to T and B cells , NK cells were administered a second time on day 7 after the initial injection (Fig. 7A).
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PMC8973725
The results of CCK-8 assay showed that cell viability was reduced at 24, 48, and 72 h in ZNF677-expressing cells (Figure 4b), while a reduction of approximately 70–80% in colony formation was observed in ZNF677-expressing cells compared to control cells (Figure 4c).
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PMC9622879
For the LEC with communal DERs, a system-centric CEMS with an operator is usually needed to control and provide their energy to every home optimistically.
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PMC9429973
Secondary endpoints include the composite end point of infection and warts, infection rates and severity, change from baseline in cutaneous warts, and number of hours above absolute lymphocyte count (ALC) of ≥1000 cells/µL over a 24-hour period, and patient-reported quality-of-life assessment using age-appropriate questionnaires.
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PMC10073922
In doing so, A549 cells were transfected with NDRG2 or mock plasmids, as described previously.
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PMC9429973
Grade ≥3 adverse events (AEs) with gilteritinib (97.3%) vs SC (94.2%) were comparable; serious AE rates were higher for gilteritinib (73.5%) vs SC (61.5%).
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PMC9429973
Two of these patients relapsed with CD38 ALL 5 and 7 months after SCT, respectively.
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PMC11575040
By integrating the top 100 candidates from TargetScan and miRDB, we identified 22 putative miR-1270 targets (Fig. 8A).
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PMC11721587
Both S482A and AAV mutations abolished the formation of the SDS-resistant Fu dimer (Fig. 2C and fig. S3A), suggesting that Fu-R phosphorylation is essential for Fu maturation.
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PMC9429973
Image: Summary/Conclusion: IRd appeared to be effective in RRMM pts in routine clinical practice regardless of prior LEN or PI exposure, with better outcomes seen in LEN- &/or PI-non-refractory vs -refractory pts.
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PMC11180402
Migrated cells on the underside of the insert were counted using an Olympus DP71 microscope (Olympus, Center Valley, PA) across eight randomly selected fields at 50 × magnification.
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PMC8409415
In the A2780 xenograft model, tumor size in the cisplatin treatment group was significantly more suppressed than that in the PBS group on day 16 after drug administration (841.9 vs 1991.5 mm, P < .05).
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PMC9429973
We quantified the relative surface expression of BTN2A (using 107G3B5 and 7.48 mAbs) and BTN3A (using 20.1 and 108.5 mAbs) on cell lines and primary ALL blasts.
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PMC11078693
Alternatives: Any confocal microscope can be used for imaging.
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PMC11751675
Furthermore, artemisinin (8) and dihydroartemisinin (25) formed the highest number of conventional hydrogen bonds, comparable to chloroquine (the reference compound).
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PMC3813807
These findings are in agreement with a previous report demonstrating that miR-373 has oncogenic properties (11).
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PMC11026382
Nearly all mutations are contained in the near-neutral peak, including mutations at highly conserved active site positions like M20, W22, and L28.
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PMC11569208
according to manufacturer’s protocol and quantified using a NanoDrop™ One Microvolume UV-Vis Spectrophotometer (Thermo Fisher Scientific, Rockford, IL).
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PMC6222726
The only phytochemical study on this species was reported by Koulman, who found 5′-desmethoxy yatein [bursehernin or (−)-trans-methylpluviatolide (+)-trans-methylpluviatolide, which has been called dextrobursehernin (18)], morelensin (16), deoxypodophyllotoxin (15), and β-peltatin-A methylether (13).
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PMC11803149
Proteins on the gel were transferred on PVDF (Trans-Blot Turbo™ Mini PVDF, Bio-Rad, 1704156) membrane.
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PMC11756514
We included two nonencapsulated S. pneumoniae strains ATCC12213 and C-mutant that produce WTA (also known as C-polysaccharide) and LTA (also known as F-antigen), which would be exposed in the absence of CP.
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PMC4270159
To assess any effects, the secondary kinase inhibitor may be independent of the ligand and primary kinase inhibitor.
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PMC11194678
Though mounting evidence has demonstrated that the transition from a physiological liquid phase to a pathological solid phase may cause abnormal protein aggregation related to the onset and progression of various human diseases, including neurodegenerative disorders (Alberti and Hyman, 2021; Ross and Poirier, 2004), this study provides a case that excessive LLPS could exacerbate the aberrant phase separation/transition processes of these toxic proteins.
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PMC8992508
In the Hoechst 33342 accumulation assay toward the BCRP overexpressing MDCK II cell line, compounds 46 and 47 were the most potent inhibitors with a 3-fold higher potency than Ko143(5) (IC50 = 69.9, 80.0 and 221 nM, respectively).
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PMC8345486
In summary, the results indicated the inhibition of the growth of A2780cisR cells cultured with compound 2, with a simultaneous increase in drug resistance.
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PMC11806818
However, the complexity of its operational steps and low detection accuracy have hindered the development of immunosensor detection methods.
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PMC11106977
Massaccesi’s group reported that Vitamin E significantly increased levels of OGT, improving the ability of osteoblasts to respond to oxidative stress and ultimately reducing osteolysis caused by oxidation (Fig. 5) .
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PMC11541409
LOF mutations in NF1 lead to deregulated activation of the RAS/MAPK pathway, contributing to the tumorigenesis of GIST .
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PMC11687167
One study showed that 3 months of methotrexate monotherapy reduced PCSK9 levels and improved psoriasis, indicating that PSCK9 could be used as a marker of psoriasis activity .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "study", "showed", "that", "3", "months", "of", "methotrexate", "monotherapy", "reduced", "PCSK9", "levels", "and", "improved", "psoriasis", ",", "indicating", "that", "PSCK9", "could", "be", "used", "as", "a", "marker", "of", "psoriasis", "activity", "." ] } ]
PMC11697189
Additionally, the impact of HSPA7 on the viability and cell cycle of ccRCC cells was also investigated.
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PMC11763111
All data are presented as mean ± SEM and analyzed by two-tailed unpaired Student's t-test, except noted by one-way ANOVA and log-rank test (Mantel-Cox). *
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PMC11075223
FA (0 ~ 40 μM) had an effect on fibroblast growth factor receptor 1-induced phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) pathway, resulting in repressing the proliferation of melanoma cells and angiogenesis .
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PMC11495567
Without the carboxyl terminal posttranslational modifications that are essential for their functional localization, their growth signaling will be impaired.
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PMC11697189
Fig. 7Correlation analysis between risk score and tumor infiltrating immune cells. (
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PMC9429973
Response rates were similar between Cld and Pt, as described in literature.
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PMC11723947
It has, for example, been documented that domain-swapping between different paralogs can affect their respective nuclear localization and biological function.
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PMC11640555
Furthermore, to confirm the ability of the casein kinase 2 inhibitor (CX-4945) to arrest the proliferation of U-87 cells, the colony formation assay was performed (Figure 1E–H, score Figure 1I), and the results obtained demonstrate that CX-4945 significantly counteracted cell proliferation in a concentration-dependent manner (Figure 1E–H, score Figure 1I) compared to the control group (Figure 1E, score Figure 1I).
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PMC11495567
The number of invaded cells was determined using the NIS-Elements and analyzed by One-Way ANOVA with Dunnett’s posthoc test, statistical significance (*p < 0.05, **p < 0.01, and ***p< 0.001).
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PMC11437637
Lymphocyte imbalance is known to lead to abnormal cytokine secretion and inflammation, which leads to disease progression [10, 31–33].
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PMC11593713
The Minimum Essential Medium with Earle’s BSS (Sartorius, Göttingen, Germany) for A549 and HeLa cell lines and Dulbeco’s Minimum Essential Medium with Earle’s BSS with an addition of 10% fetal bovine serum (FBS) (Sartorius, Göttingen, Germany) for HT-29 cell line were used as growing medium.
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PMC6461034
Viability of PDX‐derived organoids in response to target inhibition.
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PMC11281366
This standard curve was generated by extracting and amplifying DNA from serially diluted ACH-2 cells, which contain a single integrated copy of HIV-1 (NIH HIV Reagent Program).
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PMC11244823
Luciferase activity was determined in the soluble contents of the supernatants before each of them was diluted to a starting luciferase activity of 10 RLU/50 μL. Next, a LIPS assay using an anti-V5 monoclonal antibody (mAb) was done with each soluble antigen.
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PMC11172027
The use of 250 and 500 µg/mL of NALM after 72 h of incubation on Jurkat cells also showed no difference to the initial control.
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PMC10522430
The G. applanatum extract was obtained via boiling distilled water.
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PMC11078693
Check that the coated side of the cover glass is facing up.
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PMC9429973
Best overall response rate was 82.4 %, including 66.2% complete remissions (CR).
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PMC11774251
We performed in vivo experiments on IMQ-treated mice, applying Tan-I or a vehicle topically once daily for six days to examine the effects of Tan-I (Figure 1B).
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PMC2944824
To conduct terminal transferase-mediated biotinylated-UTO nick end-labeling (TUNEL) staining, mice were perfused with PBS/4% formaldehyde and the brains were post-fixed in the same buffer.
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PMC10218459
Comparing the cytostatics in terms of their effectiveness showed that both cytostatics were effective, but VIN has the strongest influence on both cell lines, indicated by a significantly lower IC50 (Figure 1).
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PMC11129910
This subtype of triple-negative breast cancer is molecularly characterized by a stem-like nature with CD44high/CD24low levels and undergoes EMT , and this is consistent with our findings.
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PMC11334037
After overnight incubation, the cells were treated with imatinib at 0, 20, 40, 60, and 80 μmol/L for 48 h. CompuSyn software was used to calculate the combination index using the Chou-Talalay method to determine the antagonistic influence.
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PMC9712534
The vast majority of molecules of nuclear proteins rapidly move by stochastic diffusion.
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PMC11597291
Data analysis was performed with the WinMDI cytometry analysis software (version 2.8).
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PMC11306019
The daily consumption of tea is estimated at about 2.5 cups, with an average of 2.5 g of tea leaves per cup (Shen and Chen, 2008; Inoue-Choi et al., 2010; Additives et al., 2018).
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PMC9024365
Indeed, a recent study demonstrated overlap of SD4 with early endosomes in hippocampal neurons (Martin et al., 2021), consistent with its role in clustering AMPARs that have been internalized.
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PMC9429973
Monoclonal antibodies used: CD14, CD16, CD300e, HLA-DR, CD64, CD38, CD45.
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PMC11679033
There is a legitimate concern about the presence of contaminants, including mycotoxins, in cannabidiol oil (CBD) and other supplements, but studies on monitoring mycotoxins in these products are rather scarce; on the other hand, the human health risk assessment methods commonly used for regulating food and pharmaceuticals have not yet been standardized for the emerging cannabis and hemp industries .
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PMC2777936
Expression of FZD5 and FZD7 proteins in NT2/D1 cells was quantified using immunoblotting on non-reducing gels.
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PMC6948907
Addition and removal of acetate groups (acetylation and deacetylation) are catalyzed by these enzymes (Turner, 1991).
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PMC6133382
This representative plot (F) is shown for demonstrative process purposes only.
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PMC10571053
As targeted therapies are known to act as inhibitors of ABC transporters, we next characterized the ability of the FINs to act as inhibitors of P-gp or ABCG2.
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PMC11738017
Within the EMD subgroup in this cohort with available sBCMA data (n = 27), a high baseline sBCMA level led to even shorter survival outcomes (Figure 6B).
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PMC11733919
SA-β-gal activity is presented in relative fluorescence units (RFU).
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PMC7841189
The mice were maintained under pathogen-free conditions at 22°C, with 40%–50% humidity and a 12-h light/dark cycle, and allowed access to food and water ad libitum.
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PMC9429973
Nipocalimab is a fully human, effectorless IgG1 monoclonal antibody in clinical development for wAIHA.
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PMC10798140
The resulting mixture was refluxed overnight.
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PMC9429973
23 pts (13 HMA-naïve MDS, 4 HMA-naïve CMML, 4 HMA-failure MDS, 2 HMA-failure CMML) were enrolled.
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PMC6468656
The mRNA levels were also determined by real-time PCR with ABI StepOnePlus real-time PCR system according to the manufacturer’s instructions.
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PMC11724582
Abnormalities in the signal transduction pathway of TGF-β1 are important factors in cancer development, progression, infiltration, and metastasis.
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PMC11173119
We performed spontaneous differentiation in embryoid bodies (Figure 1F) and used an immunofluorescence analysis of differentiated cells to show the expression of mesoderm markers (α-smooth muscle actin (αSMA) and the surface marker CD29), ectoderm (tubulin β 3 (TUBB3/TUJ1) and mature neural cell markers methionine aminopeptidase 2 (MAP2)), endoderm (alpha-fetoprotein (AFP), and cytokeratin 18 (CK18)) (Figure 1G).
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PMC11742047
For each cell line, two groups were studied (5 replicates each): non-treated cells (control at 48 h) and treated cells with pure CBD (CBD group).
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PMC11551844
MS data were recorded using the full scanning mode from 40 to 580 (amu).
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PMC9587866
The active amino acids surrounding the active pocket of EYA3 was 10 and the recorded conservation score was 0.675.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "active", "amino", "acids", "surrounding", "the", "active", "pocket", "of", "EYA3", "was", "10", "and", "the", "recorded", "conservation", "score", "was", "0.675", "." ] } ]
PMC9512971
An important pharmacokinetic (PK) feature of camostat mesilate is that when orally administered, it is rapidly metabolized into an active metabolite (GBPA) by esterases [28–30].
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PMC11566417
Blood collection was covered by Cornell University IACUC #2014–0038.
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PMC11773391
Among them, the use of oncolytic virus or mRNA‐based melanoma vaccines in melanoma treatment deserves special attention .
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PMC9429973
By addressing stakeholder questions, researchers can simultaneously advance the uptake of their research into practice and improve the quality of life of those with the disease.
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PMC10093184
The ability to form spheroids was confirmed for COS3600, COS3600B, and COS4074 cells.
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PMC11534377
Longitudinal in vivo monitoring of xenograft development was executed using the IVIS SPECTRUM (Perkin Elmer, USA), using a bioluminescent reporter (IVISbrite D-luciferin, RediJect, Perkin Elmer).
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PMC8414691
IN = input, IP = immunoprecipitation Lastly, we investigated whether the association of SRCAP with the mitotic apparatus and defects in cell division observed after its depletion are unique to human cells or are evolutionarily conserved.
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PMC11779960
In the arising paper, we described the structural basis for antibody discrimination between TRBC1 and 2 and described a TRBC2 directed therapy.
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PMC11194678
Representative images showing the droplets of Cy5-STAU1 (5 μM, magenta) could not enrich OSKAR 3′UTR (40 ng, green) stained by SYTO12. (
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PMC11469524
Phosphosites significantly regulated by p38 inhibitor SB203580 (limma, FDR≤5%).
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PMC9545474
These results suggest that the complexes have a different mode of action from that of cisplatin; such a tendency has been previously observed for arene ruthenium metal‐based drugs.
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PMC11290772
Lysis rate of primary ovarian tumor cells from patient #01, #02, #03 and #04 by PBMC-NK and ROBO1-NK after 24 h, detected with CCK-8 assay. (
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PMC11488203
Conversely, these taxol-loaded EVs/exosomes from MSC270816 displayed higher cytotoxic effects on the lower proliferating cancer cells HT-29 and CCF-STTG1 (Fig. 2D, F).
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PMC11792090
These results indicate that E066 CAR-T cells exhibit minimal fratricide compared to P8F8 CAR-T cells.
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PMC11422497
The functional roles of circRNAs are diverse and impactful.
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PMC11467964
For each analysis, a p < .05 was considered statistically significant.
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PMC6600592
This residue was dissolved in ethyl acetate (20 mL), then washed with saturated sodium chloride solution (20 mL × 3).
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PMC10706275
The amplified PCR fragment measured 865 base pairs in size.
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PMC11352311
We believe that this phenomenon is due to cellular heterogeneity, which results in different effective concentrations of the same drug across various cell lines within the same disease .
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