OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11592008	NHEK/SVTERT3-5cells were purchased from EVERCYTE GmbH (Vienna, Austria) and cultured in KBMTM-2 basal medium (Lonza, Cat# CC-3103) supplemented with KGMTM-2 SingleQuots TM (Cat# CC-4152; Lonza, Basel, Switzerland) and 50 µg/mL G418 (Cat# ant-gn5; InvivoGen, San Diego, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NHEK/SVTERT3", "-", "5cells", "were", "purchased", "from", "EVERCYTE", "GmbH", "(", "Vienna", ",", "Austria", ")", "and", "cultured", "in", "KBMTM-2", "basal", "medium", "(", "Lonza", ",", "Cat", "#", "CC-3103", ")", "supplemented", "with", "KGMTM-2", "SingleQuots", "TM", "(", "Cat", "#", "CC-4152", ";", "Lonza", ",", "Basel", ",", "Switzerland", ")", "and", "50", "µg/mL", "G418", "(", "Cat", "#", "ant-gn5", ";", "InvivoGen", ",", "San", "Diego", ",", "CA", ",", "USA", ")", "." ] } ]
PMC11248911	Using flow cytometry, cell cycle inhibition was used to assess tumor cells growth arrest after treatment of MCF7 cell line with compound 8, Fig. 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "flow", "cytometry", ",", "cell", "cycle", "inhibition", "was", "used", "to", "assess", "tumor", "cells", "growth", "arrest", "after", "treatment", "of", "MCF7", "cell", "line", "with", "compound", "8", ",", "Fig.", "4", "." ] } ]
PMC11352877	This phenomenon could represent substantial angiogenic activity in A2780 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "This", "phenomenon", "could", "represent", "substantial", "angiogenic", "activity", "in", "A2780", "cells", "." ] } ]
PMC11502327	The combination with drugs is also the most common type of nanomedicine formulation currently approved (164).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "with", "drugs", "is", "also", "the", "most", "common", "type", "of", "nanomedicine", "formulation", "currently", "approved", "(", "164", ")", "." ] } ]
PMC9503669	Chemical shift perturbations induced by DLC27 map to a hydrophobic pocket that includes conserved Nef residues Trp113 and Phe90 (numbering based on Nef crystal structure in complex with a Src-family kinase SH3 domain; PDB ID: 1EFN).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemical", "shift", "perturbations", "induced", "by", "DLC27", "map", "to", "a", "hydrophobic", "pocket", "that", "includes", "conserved", "Nef", "residues", "Trp113", "and", "Phe90", "(", "numbering", "based", "on", "Nef", "crystal", "structure", "in", "complex", "with", "a", "Src-family", "kinase", "SH3", "domain", ";", "PDB", "ID", ":", "1EFN", ")", "." ] } ]
PMC9429973	Multiple data elements were extracted, including number of people screened and diagnosed, prevalence, birth prevalence, mortality/survival/life expectancy, geographic region, years of data collection, genotype and age category.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiple", "data", "elements", "were", "extracted", ",", "including", "number", "of", "people", "screened", "and", "diagnosed", ",", "prevalence", ",", "birth", "prevalence", ",", "mortality/survival/life", "expectancy", ",", "geographic", "region", ",", "years", "of", "data", "collection", ",", "genotype", "and", "age", "category", "." ] } ]
PMC11544122	HEK293 cells transiently expressing FLAG-CXCR4, Rluc8-SNX9, and plasma membrane-targeted BRET acceptor Sapphire (PM-SAP) were stimulated for 30 min at 37 °C with increasing concentrations of CXCL12.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HEK293", "cells", "transiently", "expressing", "FLAG-CXCR4", ",", "Rluc8-SNX9", ",", "and", "plasma", "membrane-targeted", "BRET", "acceptor", "Sapphire", "(", "PM-SAP", ")", "were", "stimulated", "for", "30", "min", "at", "37", "°", "C", "with", "increasing", "concentrations", "of", "CXCL12", "." ] } ]
PMC9429973	Pediatric chemotherapy has increased survival from 48 to 70% in High income countries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pediatric", "chemotherapy", "has", "increased", "survival", "from", "48", "to", "70", "%", "in", "High", "income", "countries", "." ] } ]
PMC5963610	Many other epithelial murine and human tumor cells line have this behavior too.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "other", "epithelial", "murine", "and", "human", "tumor", "cells", "line", "have", "this", "behavior", "too", "." ] } ]
PMC11752767	The patients who received TILs therapy yielded a 49% objective response rate, with the figure for whom received ipilimumab therapy being 21% .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patients", "who", "received", "TILs", "therapy", "yielded", "a", "49", "%", "objective", "response", "rate", ",", "with", "the", "figure", "for", "whom", "received", "ipilimumab", "therapy", "being", "21", "%", "." ] } ]
PMC11626627	The present study was authorized by the Ethics Committee of the Second Hospital of Hebei Medical University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "present", "study", "was", "authorized", "by", "the", "Ethics", "Committee", "of", "the", "Second", "Hospital", "of", "Hebei", "Medical", "University", "." ] } ]
PMC11742670	XAI plays a crucial role in analyzing and interpreting intricate chemical data, enabling the formulation of innovative pharmacological hypotheses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "XAI", "plays", "a", "crucial", "role", "in", "analyzing", "and", "interpreting", "intricate", "chemical", "data", ",", "enabling", "the", "formulation", "of", "innovative", "pharmacological", "hypotheses", "." ] } ]
PMC5810978	Although human volunteer studies showed that histopathological changes occurred in the small intestine of HuNoV-infected individuals , the cell type(s) in which human HuNoVs replicate in immunocompetent individuals are still unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "human", "volunteer", "studies", "showed", "that", "histopathological", "changes", "occurred", "in", "the", "small", "intestine", "of", "HuNoV-infected", "individuals", ",", "the", "cell", "type(s", ")", "in", "which", "human", "HuNoVs", "replicate", "in", "immunocompetent", "individuals", "are", "still", "unknown", "." ] } ]
PMC9429973	Some members of the HES gene family of transcription factors, like HES1 and HES4, are known Notch targets and have important roles in hematopoiesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "members", "of", "the", "HES", "gene", "family", "of", "transcription", "factors", ",", "like", "HES1", "and", "HES4", ",", "are", "known", "Notch", "targets", "and", "have", "important", "roles", "in", "hematopoiesis", "." ] } ]
PMC9429973	Methods: In this ongoing, multicenter, single-arm, phase 2 study in the US, eligible acalabrutinib-intolerant pts with CLL/SLL, WM, MCL, or MZL who met protocol-defined acalabrutinib-intolerance criteria and gave informed consent were enrolled in cohort 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "In", "this", "ongoing", ",", "multicenter", ",", "single-arm", ",", "phase", "2", "study", "in", "the", "US", ",", "eligible", "acalabrutinib-intolerant", "pts", "with", "CLL/SLL", ",", "WM", ",", "MCL", ",", "or", "MZL", "who", "met", "protocol-defined", "acalabrutinib-intolerance", "criteria", "and", "gave", "informed", "consent", "were", "enrolled", "in", "cohort", "2", "." ] } ]
PMC10919056	The 5-year survival rate for patients with ccRCC varies depending on the stage of the disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "5-year", "survival", "rate", "for", "patients", "with", "ccRCC", "varies", "depending", "on", "the", "stage", "of", "the", "disease", "." ] } ]
PMC9429973	The median age of patients was 65 months, ranging from 9 months to 17 years at the time of the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "of", "patients", "was", "65", "months", ",", "ranging", "from", "9", "months", "to", "17", "years", "at", "the", "time", "of", "the", "study", "." ] } ]
PMC11566417	Approximately 14 days after plating, mammospheres were transferred to adherent plates and allowed to form 2 dimensional MDEC cultures, which were then used for downstream experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "14", "days", "after", "plating", ",", "mammospheres", "were", "transferred", "to", "adherent", "plates", "and", "allowed", "to", "form", "2", "dimensional", "MDEC", "cultures", ",", "which", "were", "then", "used", "for", "downstream", "experiments", "." ] } ]
PMC9429973	Summary/Conclusion: CPX-351 allowed most of MRC-AML and t-AML patients to reach HSCT in CR despite high risk genetics and even when used in patients who relapsed after a 1 HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "CPX-351", "allowed", "most", "of", "MRC-AML", "and", "t-AML", "patients", "to", "reach", "HSCT", "in", "CR", "despite", "high", "risk", "genetics", "and", "even", "when", "used", "in", "patients", "who", "relapsed", "after", "a", "1", "HSCT", "." ] } ]
PMC11297139	Bars represents mean ± SEM; n = 3 technical replicates; p < 0.01, *p < 0.001, NS non-significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bars", "represents", "mean", "±", "SEM", ";", "n", "=", "3", "technical", "replicates", ";", "", "", "p", "<", "0.01", ",", "", "", "*", "p", "<", "0.001", ",", "NS", "non-significant", "." ] } ]
PMC11590870	These findings highlight the potential of Moringa oleifera leaf peptides as functional ingredients with significant health benefits, demonstrating antioxidant and antiproliferative properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "highlight", "the", "potential", "of", "Moringa", "oleifera", "leaf", "peptides", "as", "functional", "ingredients", "with", "significant", "health", "benefits", ",", "demonstrating", "antioxidant", "and", "antiproliferative", "properties", "." ] } ]
PMC9429973	Cambridge; Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands Background: Sickle cell disease (SCD) is a monogenetic red blood cell (RBC) disorder that is characterized by hemolytic anemia and vaso-occlusive crises.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cambridge", ";", "Van", "Creveldkliniek", ",", "University", "Medical", "Center", "Utrecht", ",", "Utrecht", ",", "Netherlands", "Background", ":", "Sickle", "cell", "disease", "(", "SCD", ")", "is", "a", "monogenetic", "red", "blood", "cell", "(", "RBC", ")", "disorder", "that", "is", "characterized", "by", "hemolytic", "anemia", "and", "vaso-occlusive", "crises", "." ] } ]
PMC10812665	The statistical analysis was conducted using a moderated t-test statistics implemented by the R package limma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statistical", "analysis", "was", "conducted", "using", "a", "moderated", "t-test", "statistics", "implemented", "by", "the", "R", "package", "limma", "." ] } ]
PMC11126803	The transcripts produced by 4% to 9% of the mammalian genome sequence are LncRNAs, while the corresponding protein-coding RNA ratio is 1% (27).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transcripts", "produced", "by", "4", "%", "to", "9", "%", "of", "the", "mammalian", "genome", "sequence", "are", "LncRNAs", ",", "while", "the", "corresponding", "protein-coding", "RNA", "ratio", "is", "1", "%", "(", "27", ")", "." ] } ]
PMC6461034	Centrifuge in a microcentrifuge for 15 min at maximum speed and at room temperature for samples in 1.5‐ or 2‐ml Eppendorf tubes, or for 30 min at 6,000 × g if the volume is larger.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Centrifuge", "in", "a", "microcentrifuge", "for", "15", "min", "at", "maximum", "speed", "and", "at", "room", "temperature", "for", "samples", "in", "1.5‐", "or", "2‐ml", "Eppendorf", "tubes", ",", "or", "for", "30", "min", "at", "6,000", "×", "g", "if", "the", "volume", "is", "larger", "." ] } ]
PMC10850553	p < 0.05, **p < 0.01. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ",", "", "", "p", "<", "0.01", ".", "(" ] } ]
PMC5941560	The most publicized of these defects was aberrant PI3K signaling due to the absence of PTEN and INPP5D (SHIP) in Jurkat cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "most", "publicized", "of", "these", "defects", "was", "aberrant", "PI3", "K", "signaling", "due", "to", "the", "absence", "of", "PTEN", "and", "INPP5D", "(", "SHIP", ")", "in", "Jurkat", "cells", "." ] } ]
PMC11612626	In collaboration with MS Bioworks, MS was performed to isolate, sequence, identify, and quantitate the effect of compound A on MHC-I–bound antigenic peptides in E.G7-Ova and multiple myeloma cells (28).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "collaboration", "with", "MS", "Bioworks", ",", "MS", "was", "performed", "to", "isolate", ",", "sequence", ",", "identify", ",", "and", "quantitate", "the", "effect", "of", "compound", "A", "on", "MHC-I", "–", "bound", "antigenic", "peptides", "in", "E.G7-Ova", "and", "multiple", "myeloma", "cells", "(", "28", ")", "." ] } ]
PMC9429973	Importantly, in vitro treatment with glycolysis inhibitor 3PO improved the activity of T cells derived from aGvHD patients through down-regulating glycolytic activity of T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "in", "vitro", "treatment", "with", "glycolysis", "inhibitor", "3PO", "improved", "the", "activity", "of", "T", "cells", "derived", "from", "aGvHD", "patients", "through", "down-regulating", "glycolytic", "activity", "of", "T", "cells", "." ] } ]
PMC11577421	Overall, these observations suggest that the cell glycocalyx may play a significant role in modulating the endocytosis of ABNPs, although this possibility remains unrecognized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "these", "observations", "suggest", "that", "the", "cell", "glycocalyx", "may", "play", "a", "significant", "role", "in", "modulating", "the", "endocytosis", "of", "ABNPs", ",", "although", "this", "possibility", "remains", "unrecognized", "." ] } ]
PMC11612315	Similarly, in the von Frey test, mice injected with intraplantar vehicle after CFA induction displayed slow recovery of mechanical allodynia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "in", "the", "von", "Frey", "test", ",", "mice", "injected", "with", "intraplantar", "vehicle", "after", "CFA", "induction", "displayed", "slow", "recovery", "of", "mechanical", "allodynia", "." ] } ]
PMC11139449	PAM plus gRNAs were cloned in PX460-1, which contains a CAG promoter- Enhanced green fluorescent protein (EGFP)-bovine growth hormone polyadenylation signal and a U6 promoter-sgRNA insertion site-sgRNA scaffold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PAM", "plus", "gRNAs", "were", "cloned", "in", "PX460", "-", "1", ",", "which", "contains", "a", "CAG", "promoter-", "Enhanced", "green", "fluorescent", "protein", "(EGFP)-bovine", "growth", "hormone", "polyadenylation", "signal", "and", "a", "U6", "promoter-sgRNA", "insertion", "site-sgRNA", "scaffold", "." ] } ]
PMC11673128	In a therapeutic context, anti-CD47 mAb may inhibit CD47 DEMs, thus inducing phagocytosis of cancer cells expressing pro-phagocytic molecules .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "therapeutic", "context", ",", "anti-CD47", "mAb", "may", "inhibit", "CD47", "DEMs", ",", "thus", "inducing", "phagocytosis", "of", "cancer", "cells", "expressing", "pro-phagocytic", "molecules", "." ] } ]
PMC9884169	Plates with colonies were dried in normal air at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plates", "with", "colonies", "were", "dried", "in", "normal", "air", "at", "room", "temperature", "." ] } ]
PMC9817179	We quantified the fixation-induced changes of LLPS appearance by calculating three parameters from the fluorescence images of cells, including the number of puncta, surface roughness, and punctate percentage, and found a significant increase in all three parameters after fixation (Figure 1D–F, Figure 1—source data 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "quantified", "the", "fixation-induced", "changes", "of", "LLPS", "appearance", "by", "calculating", "three", "parameters", "from", "the", "fluorescence", "images", "of", "cells", ",", "including", "the", "number", "of", "puncta", ",", "surface", "roughness", ",", "and", "punctate", "percentage", ",", "and", "found", "a", "significant", "increase", "in", "all", "three", "parameters", "after", "fixation", "(", "Figure", "1D", "–", "F", ",", "Figure", "1—source", "data", "1", ")", "." ] } ]
PMC11637284	This is likely mainly due to as yet unknown posttranslational modifications, see for a more detailed discussion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "likely", "mainly", "due", "to", "as", "yet", "unknown", "posttranslational", "modifications", ",", "see", "for", "a", "more", "detailed", "discussion", "." ] } ]
PMC9429973	Median duration of treatment was 16.4 (range 2.1–53.1) weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "duration", "of", "treatment", "was", "16.4", "(", "range", "2.1–53.1", ")", "weeks", "." ] } ]
PMC10530622	It exhibits strong inhibitory effects on LDH and has shown the ability to reduce urine oxalate levels in cell cultures and animal models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "exhibits", "strong", "inhibitory", "effects", "on", "LDH", "and", "has", "shown", "the", "ability", "to", "reduce", "urine", "oxalate", "levels", "in", "cell", "cultures", "and", "animal", "models", "." ] } ]
PMC11656657	For the negative control, PBMC were cultured in medium for 72 h, conditioned medium (CM3) was collected, 0.4 µm filtered and stored at −20 °C, whereas the cells were characterized by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "negative", "control", ",", "PBMC", "were", "cultured", "in", "medium", "for", "72", "h", ",", "conditioned", "medium", "(", "CM3", ")", "was", "collected", ",", "0.4", "µm", "filtered", "and", "stored", "at", "−20", "°", "C", ",", "whereas", "the", "cells", "were", "characterized", "by", "flow", "cytometry", "." ] } ]
PMC11640115	The NLR, mGPS, and imGPS were then calculated from the blood test data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NLR", ",", "mGPS", ",", "and", "imGPS", "were", "then", "calculated", "from", "the", "blood", "test", "data", "." ] } ]
PMC8540611	The complexes did not have time to leave the endosomes and were lysed in them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "complexes", "did", "not", "have", "time", "to", "leave", "the", "endosomes", "and", "were", "lysed", "in", "them", "." ] } ]
PMC11621493	Differential gene expression between KO and WT cells is visualized in a heat map, displaying the z-score (indicates number of SDs a data point is from the mean of the dataset).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differential", "gene", "expression", "between", "KO", "and", "WT", "cells", "is", "visualized", "in", "a", "heat", "map", ",", "displaying", "the", "z-score", "(", "indicates", "number", "of", "SDs", "a", "data", "point", "is", "from", "the", "mean", "of", "the", "dataset", ")", "." ] } ]
PMC11126803	We ectopically increased the expression (oe) of this LncRNA in A498 cells and knocked down (sh) this LncRNA in 786-O cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "We", "ectopically", "increased", "the", "expression", "(", "oe", ")", "of", "this", "LncRNA", "in", "A498", "cells", "and", "knocked", "down", "(", "sh", ")", "this", "LncRNA", "in", "786-O", "cells", "." ] } ]
PMC9985266	The main histopathological features of lung fibroblasts include fibroblasts losing control of proliferation and excessive accumulation of the extracellular matrix (ECM) deposited by muscle fibroblasts (differentiated from lung fibroblasts) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "main", "histopathological", "features", "of", "lung", "fibroblasts", "include", "fibroblasts", "losing", "control", "of", "proliferation", "and", "excessive", "accumulation", "of", "the", "extracellular", "matrix", "(", "ECM", ")", "deposited", "by", "muscle", "fibroblasts", "(", "differentiated", "from", "lung", "fibroblasts", ")", "." ] } ]
PMC11013014	IR (neat): ν = 3411 (NH), 3387 (NH), 3321 (NH), 1664 (C=O Ketone), 1652 (C=O Amide) cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IR", "(", "neat", "):", "ν", "=", "3411", "(", "NH", ")", ",", "3387", "(", "NH", ")", ",", "3321", "(", "NH", ")", ",", "1664", "(", "C", "=", "O", "Ketone", ")", ",", "1652", "(", "C", "=", "O", "Amide", ")", "cm", "." ] } ]
PMC11257988	AKT plays an important role in inhibiting NF-KB and multiple RAS functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AKT", "plays", "an", "important", "role", "in", "inhibiting", "NF-KB", "and", "multiple", "RAS", "functions", "." ] } ]
PMC11040965	Under conditions of CD28 stimulation, all five examined components (PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, phospho-AKT) were detected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "conditions", "of", "CD28", "stimulation", ",", "all", "five", "examined", "components", "(", "PI3Kα", ",", "PI3Kβ", ",", "PI3Kγ", ",", "PI3Kδ", ",", "phospho-AKT", ")", "were", "detected", "." ] } ]
PMC9429973	38.1% achieved red cell transfusion independence and 38.1% was platelet transfusion independent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "38.1", "%", "achieved", "red", "cell", "transfusion", "independence", "and", "38.1", "%", "was", "platelet", "transfusion", "independent", "." ] } ]
PMC9429973	In index cases, mutations were heterozygous in 92%, homozygous in 6%, and X-linked in 2%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "index", "cases", ",", "mutations", "were", "heterozygous", "in", "92", "%", ",", "homozygous", "in", "6", "%", ",", "and", "X-linked", "in", "2", "%", "." ] } ]
PMC10654497	Through chi square test analysis of clinical data related to patients with Cluster1 and Cluster2 subtypes, we found that the proportion of male patients with C2 subtype was higher than that with C1 subtype, and the death outcome of C2 subtype patients was significantly higher than that of C1 subtype patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "chi", "square", "test", "analysis", "of", "clinical", "data", "related", "to", "patients", "with", "Cluster1", "and", "Cluster2", "subtypes", ",", "we", "found", "that", "the", "proportion", "of", "male", "patients", "with", "C2", "subtype", "was", "higher", "than", "that", "with", "C1", "subtype", ",", "and", "the", "death", "outcome", "of", "C2", "subtype", "patients", "was", "significantly", "higher", "than", "that", "of", "C1", "subtype", "patients", "." ] } ]
PMC10606998	Increased formation of the superoxide radical and its conversion within the cell lead to an increase in other active forms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increased", "formation", "of", "the", "superoxide", "radical", "and", "its", "conversion", "within", "the", "cell", "lead", "to", "an", "increase", "in", "other", "active", "forms", "." ] } ]
PMC8751435	Cells were analyzed by flow cytometry (FC500, Beckman).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "analyzed", "by", "flow", "cytometry", "(", "FC500", ",", "Beckman", ")", "." ] } ]
PMC9429973	Six months after the initiation of the TKI at 400 mg/day, the patient presented a severe bone marrow failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Six", "months", "after", "the", "initiation", "of", "the", "TKI", "at", "400", "mg/day", ",", "the", "patient", "presented", "a", "severe", "bone", "marrow", "failure", "." ] } ]
PMC11248911	NMR spectra were assessed by Bruker 400 MHz spectrometer using TMS as the internal standard.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NMR", "spectra", "were", "assessed", "by", "Bruker", "400", "MHz", "spectrometer", "using", "TMS", "as", "the", "internal", "standard", "." ] } ]
PMC10820104	A new prenylated indole diketopiperazine alkaloid, rubrumline P (1), was isolated along with six more analogues and characterized from the fermentation culture of a marine sediment-derived fungus, Aspergillus chevalieri, collected at a depth of 15 m near the lighthouse in Dahab, Red Sea, Egypt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "new", "prenylated", "indole", "diketopiperazine", "alkaloid", ",", "rubrumline", "P", "(", "1", ")", ",", "was", "isolated", "along", "with", "six", "more", "analogues", "and", "characterized", "from", "the", "fermentation", "culture", "of", "a", "marine", "sediment-derived", "fungus", ",", "Aspergillus", "chevalieri", ",", "collected", "at", "a", "depth", "of", "15", "m", "near", "the", "lighthouse", "in", "Dahab", ",", "Red", "Sea", ",", "Egypt", "." ] } ]
PMC11040965	Treated cells (3 × 10 per sample) were washed and lysed in RIPA lysis buffer (#20–188) supplemented with protease inhibitors (#P8340) (both from Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treated", "cells", "(", "3", "×", "10", "per", "sample", ")", "were", "washed", "and", "lysed", "in", "RIPA", "lysis", "buffer", "(", "#", "20–188", ")", "supplemented", "with", "protease", "inhibitors", "(", "#", "P8340", ")", "(", "both", "from", "Sigma-Aldrich", ")", "." ] } ]
PMC11469524	Network structures of BL-2 derived starting network and final DLBC-specific networks trained on HBL-1 and OCI-LY3 data (see A). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Network", "structures", "of", "BL-2", "derived", "starting", "network", "and", "final", "DLBC-specific", "networks", "trained", "on", "HBL-1", "and", "OCI-LY3", "data", "(", "see", "A", ")", ".", "(" ] } ]
PMC9370419	Most clones were able to support high replication of HiBiT-HBx, as confirmed by fluorescence detection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "clones", "were", "able", "to", "support", "high", "replication", "of", "HiBiT-HBx", ",", "as", "confirmed", "by", "fluorescence", "detection", "." ] } ]
PMC10840195	However, 20% —30% of RCC patients are inherently resistant to sunitinib, and the remaining patients experience secondary resistance and disease progression after 6–15 months of treatment, resulting in the limited clinical efficacy of sunitinib .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "20", "%", "—30", "%", "of", "RCC", "patients", "are", "inherently", "resistant", "to", "sunitinib", ",", "and", "the", "remaining", "patients", "experience", "secondary", "resistance", "and", "disease", "progression", "after", "6–15", "months", "of", "treatment", ",", "resulting", "in", "the", "limited", "clinical", "efficacy", "of", "sunitinib", "." ] } ]
PMC11055443	The secretome of AD-MSCs significantly reduced the V. cholerae attachment and internalization on Caco-2 epithelial cells (P<0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "secretome", "of", "AD-MSCs", "significantly", "reduced", "the", "V.", "cholerae", "attachment", "and", "internalization", "on", "Caco-2", "epithelial", "cells", "(", "P<0.0001", ")", "." ] } ]
PMC9429973	Depletion of CD155 did not have a significant impact on cell growth, apoptosis or cell cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Depletion", "of", "CD155", "did", "not", "have", "a", "significant", "impact", "on", "cell", "growth", ",", "apoptosis", "or", "cell", "cycle", "." ] } ]
PMC11672142	In the absence of Fe2-sTf-(CO3)2 supplementation, there was 3.9 ± 0.6 μM Fe present in the media.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "absence", "of", "Fe2-sTf-(CO3)2", "supplementation", ",", "there", "was", "3.9", "±", "0.6", "μM", "Fe", "present", "in", "the", "media", "." ] } ]
PMC11607764	To explore the expression level pattern of PTBP1 in different tumor tissues, we evaluated the mRNA expression level of PTBP1 across various cancer types or specific cancer subtypes of TCGA by applying TIMER2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "explore", "the", "expression", "level", "pattern", "of", "PTBP1", "in", "different", "tumor", "tissues", ",", "we", "evaluated", "the", "mRNA", "expression", "level", "of", "PTBP1", "across", "various", "cancer", "types", "or", "specific", "cancer", "subtypes", "of", "TCGA", "by", "applying", "TIMER2", "." ] } ]
PMC9429973	The results showed that the level of hsa_circ_0001599 was positively correlated with IL18 level in intestinal aGVHD patients.(R2=0.832, P<0.05). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "that", "the", "level", "of", "hsa_circ_0001599", "was", "positively", "correlated", "with", "IL18", "level", "in", "intestinal", "aGVHD", "patients.(R2=0.832", ",", "P<0.05", ")", ".", "(" ] } ]
PMC11040965	At the same time, they may open new avenues for miR29b-based epi-therapeutic strategies for MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "same", "time", ",", "they", "may", "open", "new", "avenues", "for", "miR29b-based", "epi-therapeutic", "strategies", "for", "MM", "." ] } ]
PMC10212663	Although not statistically significant, this clinical cohort revealed a longer PFS in KRAS‐mt advanced LUAD patients treated with RANKL inhibitor than those without (300 vs. 133 days, p = 0.210), but not in KRAS‐wt ones (208 vs. 250 days, p = 0.334) (Figure 4(a)–(c)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "not", "statistically", "significant", ",", "this", "clinical", "cohort", "revealed", "a", "longer", "PFS", "in", "KRAS‐mt", "advanced", "LUAD", "patients", "treated", "with", "RANKL", "inhibitor", "than", "those", "without", "(", "300", "vs.", "133", "days", ",", "p", "=", "0.210", ")", ",", "but", "not", "in", "KRAS‐wt", "ones", "(", "208", "vs.", "250", "days", ",", "p", "=", "0.334", ")", "(", "Figure", "4(a)–(c", ")", ")", "." ] } ]
PMC11643361	To further evaluate the scorpionates’ activity, DNA interaction and genotoxicity assays using comet and mobility shift assays along with molecular docking studies were carried out.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "evaluate", "the", "scorpionates", "’", "activity", ",", "DNA", "interaction", "and", "genotoxicity", "assays", "using", "comet", "and", "mobility", "shift", "assays", "along", "with", "molecular", "docking", "studies", "were", "carried", "out", "." ] } ]
PMC10024132	This limitation is a significant disadvantage compared to off-the-shelf blinatumomab.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "limitation", "is", "a", "significant", "disadvantage", "compared", "to", "off-the-shelf", "blinatumomab", "." ] } ]
PMC11064533	Survival of bacteria in clumps after antibiotic stress. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "of", "bacteria", "in", "clumps", "after", "antibiotic", "stress", ".", "(" ] } ]
PMC11267830	Previous research has shown that the ribonucleoprotein encoded by THOC1 plays a crucial role in regulating the balance of myeloid progenitor cell proliferation and apoptosis in adult mice , and THOC1 deficiency also inhibits the proliferation of hepatocellular carcinoma cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "research", "has", "shown", "that", "the", "ribonucleoprotein", "encoded", "by", "THOC1", "plays", "a", "crucial", "role", "in", "regulating", "the", "balance", "of", "myeloid", "progenitor", "cell", "proliferation", "and", "apoptosis", "in", "adult", "mice", ",", "and", "THOC1", "deficiency", "also", "inhibits", "the", "proliferation", "of", "hepatocellular", "carcinoma", "cells", "." ] } ]
PMC11011837	The PCA score of polar metabolites demonstrates clear separation among the different cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PCA", "score", "of", "polar", "metabolites", "demonstrates", "clear", "separation", "among", "the", "different", "cell", "lines", "." ] } ]
PMC8345486	The Statistica software package, version 13.3 (TIBCO Software Inc., Palo Alto, CA, USA), was used for the calculations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Statistica", "software", "package", ",", "version", "13.3", "(", "TIBCO", "Software", "Inc.", ",", "Palo", "Alto", ",", "CA", ",", "USA", ")", ",", "was", "used", "for", "the", "calculations", "." ] } ]
PMC10587429	Magrolimab (Gilead Sciences Inc., San Dimas, CA). -	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Magrolimab", "(", "Gilead", "Sciences", "Inc.", ",", "San", "Dimas", ",", "CA", ")", ".", "-" ] } ]
PMC11703896	The RMSF simulation graph in Fig. 6 provides a visual comparison of these fluctuations, highlighting rapamycin’s stability across different receptor complexes relative to the positive controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RMSF", "simulation", "graph", "in", "Fig.", "6", "provides", "a", "visual", "comparison", "of", "these", "fluctuations", ",", "highlighting", "rapamycin", "’s", "stability", "across", "different", "receptor", "complexes", "relative", "to", "the", "positive", "controls", "." ] } ]
PMC11683240	Moreover, Denmark is currently experiencing a whooping cough epidemic with substantial increase in case numbers in 2023.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "Denmark", "is", "currently", "experiencing", "a", "whooping", "cough", "epidemic", "with", "substantial", "increase", "in", "case", "numbers", "in", "2023", "." ] } ]
PMC8494202	Secondly, due to the infiltrative growth of glioma cells, the recurrence and secondary of glioma are the most important reasons leading to poor prognosis and the incidence rate and mortality of glioma are positively correlated with the age of the patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondly", ",", "due", "to", "the", "infiltrative", "growth", "of", "glioma", "cells", ",", "the", "recurrence", "and", "secondary", "of", "glioma", "are", "the", "most", "important", "reasons", "leading", "to", "poor", "prognosis", "and", "the", "incidence", "rate", "and", "mortality", "of", "glioma", "are", "positively", "correlated", "with", "the", "age", "of", "the", "patients", "." ] } ]
PMC11766350	This indicated that GFP expression is reduced by both the anti-gfp shRNA as well as the production of TRAIL, which likely reduces cell viability and therefore the ability to express GFP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicated", "that", "GFP", "expression", "is", "reduced", "by", "both", "the", "anti-gfp", "shRNA", "as", "well", "as", "the", "production", "of", "TRAIL", ",", "which", "likely", "reduces", "cell", "viability", "and", "therefore", "the", "ability", "to", "express", "GFP", "." ] } ]
PMC11297139	Source data are provided as a Source Data file.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "are", "provided", "as", "a", "Source", "Data", "file", "." ] } ]
PMC8010066	Although the algD was up-regulated in the biofilm state, particularly in PA-2 and PA-3, it was down-regulated in PA-4 either in planktonic and biofilm conditions (Figs. 3c and 4d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "algD", "was", "up-regulated", "in", "the", "biofilm", "state", ",", "particularly", "in", "PA-2", "and", "PA-3", ",", "it", "was", "down-regulated", "in", "PA-4", "either", "in", "planktonic", "and", "biofilm", "conditions", "(", "Figs.", "3c", "and", "4d", ")", "." ] } ]
PMC11286266	Two sgRNA sequences targeting exons 9 and 10 of cgATF6α were incorporated into pSpCas9(BB)-2A-mTurquoise plasmid (UK2915) to generate two sgRNA/Cas9 expression plasmids (UK3021 and UK3024) according to the published procedure (Ran et al., 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "sgRNA", "sequences", "targeting", "exons", "9", "and", "10", "of", "cgATF6α", "were", "incorporated", "into", "pSpCas9(BB)-2A-mTurquoise", "plasmid", "(", "UK2915", ")", "to", "generate", "two", "sgRNA/Cas9", "expression", "plasmids", "(", "UK3021", "and", "UK3024", ")", "according", "to", "the", "published", "procedure", "(", "Ran", "et", "al.", ",", "2013", ")", "." ] } ]
PMC10218459	The combination treatment of cell line A673 with CPP and cytostatics showed an increased reduction in cell viability compared to the control treatment with argon and cytostatics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "treatment", "of", "cell", "line", "A673", "with", "CPP", "and", "cytostatics", "showed", "an", "increased", "reduction", "in", "cell", "viability", "compared", "to", "the", "control", "treatment", "with", "argon", "and", "cytostatics", "." ] } ]
PMC3035438	The chicken IgHM region from the exon CH1 to CH3 was cloned to make the targeting vector.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chicken", "IgHM", "region", "from", "the", "exon", "CH1", "to", "CH3", "was", "cloned", "to", "make", "the", "targeting", "vector", "." ] } ]
PMC6684588	Figure 3Local administration of ACE-083 in wild-type mice causes localized hypertrophy of skeletal muscle accompanied by increased force generation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "3Local", "administration", "of", "ACE-083", "in", "wild-type", "mice", "causes", "localized", "hypertrophy", "of", "skeletal", "muscle", "accompanied", "by", "increased", "force", "generation", "." ] } ]
PMC9429973	At the last follow-up, the proportion of returning to society was comparable between the HID and ISD groups, showing 78.0% versus 84.6% among children and 74.6% versus 81.2% among adults.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "last", "follow-up", ",", "the", "proportion", "of", "returning", "to", "society", "was", "comparable", "between", "the", "HID", "and", "ISD", "groups", ",", "showing", "78.0", "%", "versus", "84.6", "%", "among", "children", "and", "74.6", "%", "versus", "81.2", "%", "among", "adults", "." ] } ]
PMC6114978	Quantitative western blot for MST1, MST2 and LATS2 (the most commonly lost kinases) in the SKLMS1, RD, and A204 cell lines and compared to GCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", "western", "blot", "for", "MST1", ",", "MST2", "and", "LATS2", "(", "the", "most", "commonly", "lost", "kinases", ")", "in", "the", "SKLMS1", ",", "RD", ",", "and", "A204", "cell", "lines", "and", "compared", "to", "GCT", "." ] } ]
PMC3164356	For each of the N50 scaffolds, a vector was used to represent the read alignments in the 22 preparations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "of", "the", "N50", "scaffolds", ",", "a", "vector", "was", "used", "to", "represent", "the", "read", "alignments", "in", "the", "22", "preparations", "." ] } ]
PMC11317131	Unedited template and PE sequences were input.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unedited", "template", "and", "PE", "sequences", "were", "input", "." ] } ]
PMC11499955	In a proof of concept study, we demonstrated the potential of this approach for cancer cell immunoprofiling in culture cells, tissues and in vivo as well, thereby unveiling promising diagnostic avenues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "proof", "of", "concept", "study", ",", "we", "demonstrated", "the", "potential", "of", "this", "approach", "for", "cancer", "cell", "immunoprofiling", "in", "culture", "cells", ",", "tissues", "and", "in", "vivo", "as", "well", ",", "thereby", "unveiling", "promising", "diagnostic", "avenues", "." ] } ]
PMC11612315	One-way ANOVA followed by Dunnett’s multiple comparison test (****p < 0.0001, compared with the control, CAP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-way", "ANOVA", "followed", "by", "Dunnett", "’s", "multiple", "comparison", "test", "(", "", "", "", "", "p", "<", "0.0001", ",", "compared", "with", "the", "control", ",", "CAP", ")", "." ] } ]
PMC11087766	As expected, all five PhiPA3 proteins localized within the PhiPA3 nucleus (Fig. 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "all", "five", "PhiPA3", "proteins", "localized", "within", "the", "PhiPA3", "nucleus", "(", "Fig.", "1A", ")", "." ] } ]
PMC9429973	Comparison of DNA STR profiles from different lesions might reveal the diversity of tumor clones in MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparison", "of", "DNA", "STR", "profiles", "from", "different", "lesions", "might", "reveal", "the", "diversity", "of", "tumor", "clones", "in", "MM", "." ] } ]
PMC10547921	Therefore, in addition to tubulin inhibitors and DNA damage agents as payloads, the new generation of RNA inhibitors as payloads of ADCs has received more and more attention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "in", "addition", "to", "tubulin", "inhibitors", "and", "DNA", "damage", "agents", "as", "payloads", ",", "the", "new", "generation", "of", "RNA", "inhibitors", "as", "payloads", "of", "ADCs", "has", "received", "more", "and", "more", "attention", "." ] } ]
PMC7602170	Of note, 4E-BP1 plays a significant mechanistic role in oncogenesis, such as promoting cell growth and protein translation, and is also closely related to drug resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note", ",", "4E-BP1", "plays", "a", "significant", "mechanistic", "role", "in", "oncogenesis", ",", "such", "as", "promoting", "cell", "growth", "and", "protein", "translation", ",", "and", "is", "also", "closely", "related", "to", "drug", "resistance", "." ] } ]
PMC11402217	This indicates a 16 to 45-fold selectivity for targeting cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicates", "a", "16", "to", "45-fold", "selectivity", "for", "targeting", "cancer", "cells", "." ] } ]
PMC11317131	However, neither traditional PASTE nor twin PE PASTE reached the levels of our evolved Bxb1 integrase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "neither", "traditional", "PASTE", "nor", "twin", "PE", "PASTE", "reached", "the", "levels", "of", "our", "evolved", "Bxb1", "integrase", "." ] } ]
PMC11787651	C and D, heatmaps generated through hierarchical clustering were used to compare control and samples with two treatment conditions, M344 and entinostat, targeting HDAC inhibition observed using either the 10-min gradient ZenoTOF method or the 55-min gradient Orbitrap method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "and", "D", ",", "heatmaps", "generated", "through", "hierarchical", "clustering", "were", "used", "to", "compare", "control", "and", "samples", "with", "two", "treatment", "conditions", ",", "M344", "and", "entinostat", ",", "targeting", "HDAC", "inhibition", "observed", "using", "either", "the", "10-min", "gradient", "ZenoTOF", "method", "or", "the", "55-min", "gradient", "Orbitrap", "method", "." ] } ]
PMC11670407	d Transfected 143B cells were pretreated with 10 μM fer-1 or Z-VAD-FMK for 1 h and then treated with cisplatin (10 μM) for 24 h; apoptosis levels were assessed by flow cytometry (n = 3).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Transfected", "143B", "cells", "were", "pretreated", "with", "10", "μM", "fer-1", "or", "Z-VAD-FMK", "for", "1", "h", "and", "then", "treated", "with", "cisplatin", "(", "10", "μM", ")", "for", "24", "h", ";", "apoptosis", "levels", "were", "assessed", "by", "flow", "cytometry", "(", "n", "=", "3", ")", "." ] } ]
PMC11723947	In conclusion, we identify HP1 variants as rheostats that finely tune the balance between tolerance and immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "we", "identify", "HP1", "variants", "as", "rheostats", "that", "finely", "tune", "the", "balance", "between", "tolerance", "and", "immunity", "." ] } ]
PMC6163708	The pancreatic tumors were surprisingly most resistant to GANT61 treatment, although previous reports describe their sensitivity to the blocking of HH signaling .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pancreatic", "tumors", "were", "surprisingly", "most", "resistant", "to", "GANT61", "treatment", ",", "although", "previous", "reports", "describe", "their", "sensitivity", "to", "the", "blocking", "of", "HH", "signaling", "." ] } ]
PMC8658661	It maintains various physiological processes , predominantly replenishing and storing rapidly mobilized energy reserves in glycogen, regulating carbohydrate metabolism, and neutralizing and removing metabolic products from the body .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "maintains", "various", "physiological", "processes", ",", "predominantly", "replenishing", "and", "storing", "rapidly", "mobilized", "energy", "reserves", "in", "glycogen", ",", "regulating", "carbohydrate", "metabolism", ",", "and", "neutralizing", "and", "removing", "metabolic", "products", "from", "the", "body", "." ] } ]

PMC11592008

NHEK/SVTERT3-5cells were purchased from EVERCYTE GmbH (Vienna, Austria) and cultured in KBMTM-2 basal medium (Lonza, Cat# CC-3103) supplemented with KGMTM-2 SingleQuots TM (Cat# CC-4152; Lonza, Basel, Switzerland) and 50 µg/mL G418 (Cat# ant-gn5; InvivoGen, San Diego, CA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NHEK/SVTERT3", "-", "5cells", "were", "purchased", "from", "EVERCYTE", "GmbH", "(", "Vienna", ",", "Austria", ")", "and", "cultured", "in", "KBMTM-2", "basal", "medium", "(", "Lonza", ",", "Cat", "#", "CC-3103", ")", "supplemented", "with", "KGMTM-2", "SingleQuots", "TM", "(", "Cat", "#", "CC-4152", ";", "Lonza", ",", "Basel", ",", "Switzerland", ")", "and", "50", "µg/mL", "G418", "(", "Cat", "#", "ant-gn5", ";", "InvivoGen", ",", "San", "Diego", ",", "CA", ",", "USA", ")", "." ] } ]

PMC11248911

Using flow cytometry, cell cycle inhibition was used to assess tumor cells growth arrest after treatment of MCF7 cell line with compound 8, Fig. 4.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "flow", "cytometry", ",", "cell", "cycle", "inhibition", "was", "used", "to", "assess", "tumor", "cells", "growth", "arrest", "after", "treatment", "of", "MCF7", "cell", "line", "with", "compound", "8", ",", "Fig.", "4", "." ] } ]

PMC11352877

This phenomenon could represent substantial angiogenic activity in A2780 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "This", "phenomenon", "could", "represent", "substantial", "angiogenic", "activity", "in", "A2780", "cells", "." ] } ]

PMC11502327

The combination with drugs is also the most common type of nanomedicine formulation currently approved (164).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "with", "drugs", "is", "also", "the", "most", "common", "type", "of", "nanomedicine", "formulation", "currently", "approved", "(", "164", ")", "." ] } ]

PMC9503669

Chemical shift perturbations induced by DLC27 map to a hydrophobic pocket that includes conserved Nef residues Trp113 and Phe90 (numbering based on Nef crystal structure in complex with a Src-family kinase SH3 domain; PDB ID: 1EFN).

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PMC9429973

Multiple data elements were extracted, including number of people screened and diagnosed, prevalence, birth prevalence, mortality/survival/life expectancy, geographic region, years of data collection, genotype and age category.

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PMC11544122

HEK293 cells transiently expressing FLAG-CXCR4, Rluc8-SNX9, and plasma membrane-targeted BRET acceptor Sapphire (PM-SAP) were stimulated for 30 min at 37 °C with increasing concentrations of CXCL12.

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PMC9429973

Pediatric chemotherapy has increased survival from 48 to 70% in High income countries.

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PMC5963610

Many other epithelial murine and human tumor cells line have this behavior too.

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PMC11752767

The patients who received TILs therapy yielded a 49% objective response rate, with the figure for whom received ipilimumab therapy being 21% .

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PMC11626627

The present study was authorized by the Ethics Committee of the Second Hospital of Hebei Medical University.

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PMC11742670

XAI plays a crucial role in analyzing and interpreting intricate chemical data, enabling the formulation of innovative pharmacological hypotheses.

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PMC5810978

Although human volunteer studies showed that histopathological changes occurred in the small intestine of HuNoV-infected individuals , the cell type(s) in which human HuNoVs replicate in immunocompetent individuals are still unknown.

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PMC9429973

Some members of the HES gene family of transcription factors, like HES1 and HES4, are known Notch targets and have important roles in hematopoiesis.

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PMC9429973

Methods: In this ongoing, multicenter, single-arm, phase 2 study in the US, eligible acalabrutinib-intolerant pts with CLL/SLL, WM, MCL, or MZL who met protocol-defined acalabrutinib-intolerance criteria and gave informed consent were enrolled in cohort 2.

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PMC10919056

The 5-year survival rate for patients with ccRCC varies depending on the stage of the disease.

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PMC9429973

The median age of patients was 65 months, ranging from 9 months to 17 years at the time of the study.

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PMC11566417

Approximately 14 days after plating, mammospheres were transferred to adherent plates and allowed to form 2 dimensional MDEC cultures, which were then used for downstream experiments.

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PMC9429973

Summary/Conclusion: CPX-351 allowed most of MRC-AML and t-AML patients to reach HSCT in CR despite high risk genetics and even when used in patients who relapsed after a 1 HSCT.

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PMC11297139

Bars represents mean ± SEM; n = 3 technical replicates; **p < 0.01, ***p < 0.001, NS non-significant.

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PMC11590870

These findings highlight the potential of Moringa oleifera leaf peptides as functional ingredients with significant health benefits, demonstrating antioxidant and antiproliferative properties.

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PMC9429973

Cambridge; Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands Background: Sickle cell disease (SCD) is a monogenetic red blood cell (RBC) disorder that is characterized by hemolytic anemia and vaso-occlusive crises.

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PMC10812665

The statistical analysis was conducted using a moderated t-test statistics implemented by the R package limma .

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PMC11126803

The transcripts produced by 4% to 9% of the mammalian genome sequence are LncRNAs, while the corresponding protein-coding RNA ratio is 1% (27).

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PMC6461034

Centrifuge in a microcentrifuge for 15 min at maximum speed and at room temperature for samples in 1.5‐ or 2‐ml Eppendorf tubes, or for 30 min at 6,000 × g if the volume is larger.

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PMC10850553

p < 0.05, **p < 0.01. (

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PMC5941560

The most publicized of these defects was aberrant PI3K signaling due to the absence of PTEN and INPP5D (SHIP) in Jurkat cells .

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PMC11612626

In collaboration with MS Bioworks, MS was performed to isolate, sequence, identify, and quantitate the effect of compound A on MHC-I–bound antigenic peptides in E.G7-Ova and multiple myeloma cells (28).

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PMC9429973

Importantly, in vitro treatment with glycolysis inhibitor 3PO improved the activity of T cells derived from aGvHD patients through down-regulating glycolytic activity of T cells.

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PMC11577421

Overall, these observations suggest that the cell glycocalyx may play a significant role in modulating the endocytosis of ABNPs, although this possibility remains unrecognized.

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PMC11612315

Similarly, in the von Frey test, mice injected with intraplantar vehicle after CFA induction displayed slow recovery of mechanical allodynia.

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PMC11139449

PAM plus gRNAs were cloned in PX460-1, which contains a CAG promoter- Enhanced green fluorescent protein (EGFP)-bovine growth hormone polyadenylation signal and a U6 promoter-sgRNA insertion site-sgRNA scaffold.

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PMC11673128

In a therapeutic context, anti-CD47 mAb may inhibit CD47 DEMs, thus inducing phagocytosis of cancer cells expressing pro-phagocytic molecules .

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PMC9884169

Plates with colonies were dried in normal air at room temperature.

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PMC9817179

We quantified the fixation-induced changes of LLPS appearance by calculating three parameters from the fluorescence images of cells, including the number of puncta, surface roughness, and punctate percentage, and found a significant increase in all three parameters after fixation (Figure 1D–F, Figure 1—source data 1).

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PMC11637284

This is likely mainly due to as yet unknown posttranslational modifications, see for a more detailed discussion.

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PMC9429973

Median duration of treatment was 16.4 (range 2.1–53.1) weeks.

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PMC10530622

It exhibits strong inhibitory effects on LDH and has shown the ability to reduce urine oxalate levels in cell cultures and animal models.

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PMC11656657

For the negative control, PBMC were cultured in medium for 72 h, conditioned medium (CM3) was collected, 0.4 µm filtered and stored at −20 °C, whereas the cells were characterized by flow cytometry.

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PMC11640115

The NLR, mGPS, and imGPS were then calculated from the blood test data.

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PMC8540611

The complexes did not have time to leave the endosomes and were lysed in them.

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PMC11621493

Differential gene expression between KO and WT cells is visualized in a heat map, displaying the z-score (indicates number of SDs a data point is from the mean of the dataset).

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PMC11126803

We ectopically increased the expression (oe) of this LncRNA in A498 cells and knocked down (sh) this LncRNA in 786-O cells.

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PMC9985266

The main histopathological features of lung fibroblasts include fibroblasts losing control of proliferation and excessive accumulation of the extracellular matrix (ECM) deposited by muscle fibroblasts (differentiated from lung fibroblasts) .

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PMC11013014

IR (neat): ν = 3411 (NH), 3387 (NH), 3321 (NH), 1664 (C=O Ketone), 1652 (C=O Amide) cm.

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PMC11257988

AKT plays an important role in inhibiting NF-KB and multiple RAS functions.

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PMC11040965

Under conditions of CD28 stimulation, all five examined components (PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, phospho-AKT) were detected.

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PMC9429973

38.1% achieved red cell transfusion independence and 38.1% was platelet transfusion independent.

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PMC9429973

In index cases, mutations were heterozygous in 92%, homozygous in 6%, and X-linked in 2%.

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PMC10654497

Through chi square test analysis of clinical data related to patients with Cluster1 and Cluster2 subtypes, we found that the proportion of male patients with C2 subtype was higher than that with C1 subtype, and the death outcome of C2 subtype patients was significantly higher than that of C1 subtype patients.

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PMC10606998

Increased formation of the superoxide radical and its conversion within the cell lead to an increase in other active forms.

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PMC8751435

Cells were analyzed by flow cytometry (FC500, Beckman).

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PMC9429973

Six months after the initiation of the TKI at 400 mg/day, the patient presented a severe bone marrow failure.

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PMC11248911

NMR spectra were assessed by Bruker 400 MHz spectrometer using TMS as the internal standard.

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PMC10820104

A new prenylated indole diketopiperazine alkaloid, rubrumline P (1), was isolated along with six more analogues and characterized from the fermentation culture of a marine sediment-derived fungus, Aspergillus chevalieri, collected at a depth of 15 m near the lighthouse in Dahab, Red Sea, Egypt.

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PMC11040965

Treated cells (3 × 10 per sample) were washed and lysed in RIPA lysis buffer (#20–188) supplemented with protease inhibitors (#P8340) (both from Sigma-Aldrich).

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PMC11469524

Network structures of BL-2 derived starting network and final DLBC-specific networks trained on HBL-1 and OCI-LY3 data (see A). (

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PMC9370419

Most clones were able to support high replication of HiBiT-HBx, as confirmed by fluorescence detection.

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PMC10840195

However, 20% —30% of RCC patients are inherently resistant to sunitinib, and the remaining patients experience secondary resistance and disease progression after 6–15 months of treatment, resulting in the limited clinical efficacy of sunitinib .

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PMC11055443

The secretome of AD-MSCs significantly reduced the V. cholerae attachment and internalization on Caco-2 epithelial cells (P<0.0001).

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PMC9429973

Depletion of CD155 did not have a significant impact on cell growth, apoptosis or cell cycle.

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PMC11672142

In the absence of Fe2-sTf-(CO3)2 supplementation, there was 3.9 ± 0.6 μM Fe present in the media.

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PMC11607764

To explore the expression level pattern of PTBP1 in different tumor tissues, we evaluated the mRNA expression level of PTBP1 across various cancer types or specific cancer subtypes of TCGA by applying TIMER2.

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PMC9429973

The results showed that the level of hsa_circ_0001599 was positively correlated with IL18 level in intestinal aGVHD patients.(R2=0.832, P<0.05). (

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PMC11040965

At the same time, they may open new avenues for miR29b-based epi-therapeutic strategies for MM.

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PMC10212663

Although not statistically significant, this clinical cohort revealed a longer PFS in KRAS‐mt advanced LUAD patients treated with RANKL inhibitor than those without (300 vs. 133 days, p = 0.210), but not in KRAS‐wt ones (208 vs. 250 days, p = 0.334) (Figure 4(a)–(c)).

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PMC11643361

To further evaluate the scorpionates’ activity, DNA interaction and genotoxicity assays using comet and mobility shift assays along with molecular docking studies were carried out.

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PMC10024132

This limitation is a significant disadvantage compared to off-the-shelf blinatumomab.

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PMC11064533

Survival of bacteria in clumps after antibiotic stress. (

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PMC11267830

Previous research has shown that the ribonucleoprotein encoded by THOC1 plays a crucial role in regulating the balance of myeloid progenitor cell proliferation and apoptosis in adult mice , and THOC1 deficiency also inhibits the proliferation of hepatocellular carcinoma cells .

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PMC11011837

The PCA score of polar metabolites demonstrates clear separation among the different cell lines.

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PMC8345486

The Statistica software package, version 13.3 (TIBCO Software Inc., Palo Alto, CA, USA), was used for the calculations.

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PMC10587429

Magrolimab (Gilead Sciences Inc., San Dimas, CA). -

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PMC11703896

The RMSF simulation graph in Fig. 6 provides a visual comparison of these fluctuations, highlighting rapamycin’s stability across different receptor complexes relative to the positive controls.

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PMC11683240

Moreover, Denmark is currently experiencing a whooping cough epidemic with substantial increase in case numbers in 2023.

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PMC8494202

Secondly, due to the infiltrative growth of glioma cells, the recurrence and secondary of glioma are the most important reasons leading to poor prognosis and the incidence rate and mortality of glioma are positively correlated with the age of the patients .

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PMC11766350

This indicated that GFP expression is reduced by both the anti-gfp shRNA as well as the production of TRAIL, which likely reduces cell viability and therefore the ability to express GFP.

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PMC11297139

Source data are provided as a Source Data file.

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PMC8010066

Although the algD was up-regulated in the biofilm state, particularly in PA-2 and PA-3, it was down-regulated in PA-4 either in planktonic and biofilm conditions (Figs. 3c and 4d).

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PMC11286266

Two sgRNA sequences targeting exons 9 and 10 of cgATF6α were incorporated into pSpCas9(BB)-2A-mTurquoise plasmid (UK2915) to generate two sgRNA/Cas9 expression plasmids (UK3021 and UK3024) according to the published procedure (Ran et al., 2013).

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PMC10218459

The combination treatment of cell line A673 with CPP and cytostatics showed an increased reduction in cell viability compared to the control treatment with argon and cytostatics.

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PMC3035438

The chicken IgHM region from the exon CH1 to CH3 was cloned to make the targeting vector.

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PMC6684588

Figure 3Local administration of ACE-083 in wild-type mice causes localized hypertrophy of skeletal muscle accompanied by increased force generation.

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PMC9429973

At the last follow-up, the proportion of returning to society was comparable between the HID and ISD groups, showing 78.0% versus 84.6% among children and 74.6% versus 81.2% among adults.

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PMC6114978

Quantitative western blot for MST1, MST2 and LATS2 (the most commonly lost kinases) in the SKLMS1, RD, and A204 cell lines and compared to GCT.

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PMC3164356

For each of the N50 scaffolds, a vector was used to represent the read alignments in the 22 preparations.

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PMC11317131

Unedited template and PE sequences were input.

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PMC11499955

In a proof of concept study, we demonstrated the potential of this approach for cancer cell immunoprofiling in culture cells, tissues and in vivo as well, thereby unveiling promising diagnostic avenues.

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PMC11612315

One-way ANOVA followed by Dunnett’s multiple comparison test (****p < 0.0001, compared with the control, CAP).

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PMC11087766

As expected, all five PhiPA3 proteins localized within the PhiPA3 nucleus (Fig. 1A).

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PMC9429973

Comparison of DNA STR profiles from different lesions might reveal the diversity of tumor clones in MM.

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PMC10547921

Therefore, in addition to tubulin inhibitors and DNA damage agents as payloads, the new generation of RNA inhibitors as payloads of ADCs has received more and more attention.

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PMC7602170

Of note, 4E-BP1 plays a significant mechanistic role in oncogenesis, such as promoting cell growth and protein translation, and is also closely related to drug resistance .

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PMC11402217

This indicates a 16 to 45-fold selectivity for targeting cancer cells.

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PMC11317131

However, neither traditional PASTE nor twin PE PASTE reached the levels of our evolved Bxb1 integrase.

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PMC11787651

C and D, heatmaps generated through hierarchical clustering were used to compare control and samples with two treatment conditions, M344 and entinostat, targeting HDAC inhibition observed using either the 10-min gradient ZenoTOF method or the 55-min gradient Orbitrap method.

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PMC11670407

d Transfected 143B cells were pretreated with 10 μM fer-1 or Z-VAD-FMK for 1 h and then treated with cisplatin (10 μM) for 24 h; apoptosis levels were assessed by flow cytometry (n = 3).

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PMC11723947

In conclusion, we identify HP1 variants as rheostats that finely tune the balance between tolerance and immunity.

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PMC6163708

The pancreatic tumors were surprisingly most resistant to GANT61 treatment, although previous reports describe their sensitivity to the blocking of HH signaling .

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PMC8658661

It maintains various physiological processes , predominantly replenishing and storing rapidly mobilized energy reserves in glycogen, regulating carbohydrate metabolism, and neutralizing and removing metabolic products from the body .

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