OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11337594	The p53 signalling pathway was markedly upregulated following TER treatment, leading to the activation of CASP3 via the intrinsic apoptotic pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "p53",...
PMC9429973	At the diagnosis time RI is detected in 20-40% of patients, in 2-4% of patients with newly diagnosed MM develop dialysis-dependent RI, which is associated with early mortality and a high complications’ incidence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	Oxidative stress has been strongly associated with oxalate toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oxidative", "stress", "has", "been", "strongly", "associated", "with", "oxalate", "toxicity", "." ] }...
PMC11723947	We isolated wild-type and Hp1g naive CD4 T cells and compared their activation and differentiation following T cell receptor engagement and exposure to Th1 or Th17 lineage-specifying factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10165258	The results for D2 on spheroids cultured in 96-well plates are shown in Figure 4D and full results of these experiments are shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11792090	Additionally, the apoptotic rate of CFSE-labeled cells after co-culture with E066 CAR-T cells was approximately 7%, slightly lower than the rate observed in cells co-cultured with P8F8 CAR-T cells ( Figure 1I ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11412721	Gene expression (B, right) or survival curves (C) were plotted for the 30% patients (27 men, 20 women) with the highest or lowest ACKR4 expression, classified according to sex. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485648	Such XRE-mediated response has been associated with SFN in several cell types (10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "XRE-mediated", "response", "has", "been", "associated", ...
PMC11321678	Scores are normalized by the Z score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scores", "are", "normalized", "by", "the", "Z", "score", "." ] } ]
PMC11467964	KCND3. (	[ { "tags": [ "O", "O", "O" ], "tokens": [ "KCND3", ".", "(" ] } ]
PMC11792888	When the scorpion venom is combined with etoposide, a well-known chemotherapeutic agent, it enhances the effect of both treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "sc...
PMC11740573	Then, cultures were treated with thermally inactivated (autoclaved at 121 °C, 1.02 bar pressure, 15 min.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", ...
PMC10197932	Thus, these markers are essential for the functionality of lymphocytes, and mainly for CD8+ cytotoxic activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "these", "markers", ...
PMC9429973	In addition, Casitas B-lineage Lymphoma mutations (CBL) are observed in 10% of pts with MDS/MPN and up to 13-15% of pts with CMML (mainly proliferative type).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Exclusion criteria were lack of information on comorbidities, survival or relapse status, or age <18 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exclusion", "criteria", "were", "...
PMC9429973	No differences were observed between both populations regarding basal characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "differences", "were", "observed", "between", "both", "populations", "regarding", "basal", ...
PMC9429973	CD34CD38CLL-1 cells were smaller in size than their CD34CD38CLL-1 counter-parts and represented approximately 2% of the entire CD34CD38 subset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD34CD38CLL-1", "cells", "we...
PMC11350568	50 μM chlorpromazine was incubated with Cy5-AptG-1, Cy5-AptG-2, and Cy5-Sgc8c at the concentration of 500 nM for 2 h. Given the rapid internalization rate of AptG-1, we developed a keen interest in the pathways through which the TMPDS enters the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11568601	A total of 16 expression trends were identified using STEM software (Supplementary Fig. S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "16", "expression", "trends", ...
PMC10728200	The results showed that STUB1 knockdown effectively blocked the anti-tumor effect of IM and reduced the promotion of lipid-ROS mediated by IM (Fig. 3I, H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	2.	[ { "tags": [ "O", "O" ], "tokens": [ "2", "." ] } ]
PMC11317131	The SP backbone was modified by replacing the gene VI promoter with the RecA promoter to decrease generation of recombinant wildtype M13 phage (Supplementary Figure S8b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241	The first design, which we refer to as the basic scaffold, had cubic unit cells and was 500 × 500 × 250 m in overall size (Figure 3a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6133382	Plates were incubated for 90 minutes with shaking and then washed 4 times with 0.05% Tween PBS using an automated plate washer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plates"...
PMC11519077	The expression levels of the Collagen Type II gene in differentiated MSCs into the chondrocyte lineage were also shown to be considerably different from undifferentiated MSCs (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9031474	In further experiments, it was shown that 75 inhibits DNA binding of the transcription factors NF-kB and Stat-3 to the survivin promoter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11457557	DM and chronic hyperglycemia disrupt MiRNA expression in various tissues, impacting disease onset and progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DM", "and", "chronic", "hyperglycemia", "disrupt", "Mi...
PMC11680049	The suspension culture was cultivated in 100 and 250 mL round and conical flasks on a shaker (CRYSTY) in the dark at a temperature of 23 ± 1 °C and a rotation speed of 100 rpm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012012	This downregulation was correlated with a reduction in Bcl-2 and Mcl-1 expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "downregulation", "was", "correlated", "with", "a", "reduction", "in", "B...
PMC11674891	Ten five-week-old female nude mice (BALB/c-nude) were obtained from Orient Bio (Seongnam, Republic of Korea).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ten", "five-week-old", ...
PMC9429973	All 5 patients responded early to treatment, which became apparent immediately after the first dose of 2.5 mg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "5", "patients", "responded...
PMC11463018	For flow cytometry assay, annexin V-FITC/propidium iodide (PI) staining assay (A211-02, Vazyme) was employed to detect cells in early apoptotic and late apoptotic stages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9910796	The arrowheads indicate representative labeling.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "arrowheads", "indicate", "representative", "labeling", "." ] } ]
PMC11733919	Box and whisker plots are shown, n = 3, *p < 0.001, p < 0.01, *p < 0.05 compared to senescence control (ANOVA and Dunnett’s a posteriori test), p < 0.001, p < 0.05 compared to 17-DMAG alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Overall, 22 proteins had significantly different expression in AA_DX samples (13 up, 9 down) compared to NC with AA_PROG and PGF having 8 (4 up, 4 down) and 14 (7 up, 7 down) respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394227	Cell count was performed with a cell counting apparatus (Thermo Fisher Scientific, Waltham, MA, USA), and the cell density reached 2 × 10 cells/mL or more, which was in the logarithmic growth stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5574817	The recombinant plasmid, pCMV6-Neo-hERG was sent for DNA sequencing at Macrogen (Seoul, Korea).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "recombinant", "plasmid", ",", "pCMV6-Neo-h...
PMC8839885	Briefly, total RNA was extracted from the cells using Tri Reagent (Sigma).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "total", "RNA", "was", "extracted", "from", ...
PMC11704834	no. RPN2232; Cytiva), and band intensities were quantified by densitometric analysis using ImageJ software (National Institutes of Health).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", ...
PMC6461034	Centrifuge at 2,000 × g for 30 s at 4°C to pellet the beads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Centrifuge", "at", "2,000", "×", "g", "for", "30...
PMC11593084	All cell lines were cultured at 37 °C in a humidified atmosphere with 5% CO2 and 95% air.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "li...
PMC9429973	Approximately 250 patients will be randomized 1:1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "250", "patients", "will", "be", "randomized", "1:1", "." ] } ]
PMC8348645	There was a significant effect of different samples present at p < 0.05 level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "a", "significant", "effect", "of", "different", ...
PMC10698968	For 3D aggregate culture, cells were seeded at 600 cell/ml density in ultra-low attachment 6-well plates (Corning inc) in 2 ml of complete medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11609529	These fusions are potent oncogenic drivers, representing critical targets for both diagnostic and therapeutic interventions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "fusions", "are", "potent", "oncogenic", "driv...
PMC9429973	In this cohort, concurrent use of HCTZ and BB showed a significant trend for a lower BP [Est -5.05; 95% (-10.0, -0.06); p= 0.04].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	M. Welslau, B. Kubuschok, J. Topaly, B. Otremba, T. Wolff, G. Bryn Department of Oncology, Klinikum Aschaffenburg, Aschaffenburg; Department of Hematology/Oncology, Augsburg University Medical Center, Augsburg; Klinik für Hämatologie und Onkologie, CaritasKlinikum Saarbrücken, Saarbrücken; Onkologische Praxis Oldenburg...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	Graph, mean ± s.e.m.;	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graph", ",", "mean", "±", "s.e.m", ".", ";" ] } ]
PMC7602170	Rapamycin, an mTOR inhibitor and autophagy inducer, enhanced autophagy activity, downregulated the expression of KIT, and led to apoptosis in GIST430 and GIST48 cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC9509578	Such micellar nanomaterials have prolonged circulation time and accumulate in tumor tissues via the EPR mechanism .Table 3Nanomicelles and nanoemulsions used to overcome cancer MDRS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Median duration of therapy (DOT) was estimated using the Kaplan-Meier method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "duration", "of", "therapy", "(", "DOT", ")", "was", "estima...
PMC8584666	Therefore, the ratio of the amounts of GSH and GSSG was measured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "ratio", "of", "the", "amounts", "of", "GSH",...
PMC11377827	Mean ± sd.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Mean", "±", "sd", "." ] } ]
PMC11637820	Among these different bacteria, Staphylococcus aureus and Pseudomonas aeruginosa were found to be two of the most dominant gram-positive and gram-negative species, respectively, appearing in almost all ulcers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	The full-length ECFP-TRAF2 was not expressed and did not inhibit BCD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "full-length", "ECFP-TRAF2", "was", "not", "expressed", "and", "did", "not", "i...
PMC7709199	Other less conservative substitutions of the asparagine, or targeting the Ser/Thr site that is part of the NG motif, will also disrupt the glycosylation of a specific site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6799808	Notably, CDK1 and CDK2 were not obviously affected by GLPT treatment, despite a slight inhibitory effect of 2 mg/ml GLPT on cyclin A/E expression in A549 cells (Fig. 2c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Figure 2—figure supplement 1.Modulation of Mecp2 expression in the mouse liver.(A) Schematic diagram of loss of Mecp2 in mouse hepatocyte.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "2—figure", ...
PMC10506676	In this way, E2F enters the cell nucleus and transcribes genes related to the proliferative phase of the cell cycle, so the infected cell goes from G1 to the S-phase and continues to multiply (5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11462673	A The knockdown levels of LDB1 in cells was verified by WB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "The", "knockdown", "levels", "of", "LDB1", "in", "cells", "was", "ver...
PMC11661024	Long-term studies on the impact of extended exposure to postbiotics and the potential development of resistance in cancer cells will be helpful before concluding clinical potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6901583	The Buffy coats from healthy voluteers were used to isolate human monocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Buffy", "coats", "from", "healthy", "voluteers", "were", "used", "to", ...
PMC11470999	Spontaneous brain metastasis from a primary tumor is ideal as it allows for the study of all steps of the metastatic cascade and is simple to establish.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	Because of its specific selective binding to G-quadruplexes, telomestatin can lead to telomere degradation and induce delayed senescence and apoptosis in various types of cancer cells, such as leukemia, neuroblastoma, and cervical cancer cells, while having minimum effects on normal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543885	Figure 3Capture and biotinylation of ASC in HEK293 cells stably expressing Flag-NLRP3-APEX2(A) Schematic overview of the experimental design for treatment conditions and APEX2 induced biotinylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10495912	On the other hand, TQ (75 µM) was able to decrease the IC50 of hydrogen peroxide by 48.2 µM (Figure 1-C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11655498	EBV reactivation involves crosstalk between various factors and signaling pathways, and the subsequent complicated virus-host interplays determine whether EBV continues to propagate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EBV", ...
PMC11697065	Due to the averaging effect of the heterogeneity of the cell pools both transcriptomic and proteomic analyses resulted in a limited number of significantly differentially expressed genes or proteins that could be used for pathway analysis (Supplementary Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	Src inhibition by Tri blocked S1PR3-induced early and prolonged STAT3 activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Src", "inhibition", "by", "Tri", "blocked", "S1PR3-induced", "early", "and", "prolonged", ...
PMC11740207	One of the most widely used AML cell lines with confirmed LSLCs is HL60, which was derived through leukapheresis from the peripheral blood of a 36-year-old patient with AML (Collins, 1987).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485648	For the proliferation assay, 4×10 A2780 ovarian cancer cells and their chemoresistant variants were seeded into each well of an E-plate 16 (Roche) in DMEM containing 5 μM sulforaphane or DMSO (control samples).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9739791	Phorbiplatin 8 showed little to no toxicity in the dark on various cell lines (Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phorbiplatin", "8", "showed", "little", ...
PMC8009078	A cut-off of 8 Å was considered for the short-range nonbonded interaction, while the particle mesh Ewald method was used for the long-range electrostatics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11361748	Scale bars: 10 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "10", "μm", "." ] } ]
PMC10831439	The effect of checkpoint inhibition through nivolumab was analyzed in these settings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "checkpoint", "inhibition", "through", "nivolumab", "was", ...
PMC11726183	It is noteworthy that compound 23 with nitro substitution attached to the para position of the phenyl ring is the top contender of the entire library of compounds displaying an IC50 value of 15.8 ± 0.6 μM. It shows the importance of the electron-withdrawing group in inhibiting cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	In contrast, LT-HSCs and USSCs are more specialized towards specific lineages (hematopoietic and mesenchymal, respectively), making them less comparable to VSELSCs in terms of versatility (Ratajczak et al., 2012; Alanazi et al., 2023; Velasco et al., 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11438317	The 1854C > T polymorphism changes Arg620 by a Trp in the P1 Pro rich motif (PRM) found at the C-terminus of LYP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11644761	The intensity of the fluorescent signal was not analyzed, as our aim was to determine the number of cells with Ki67 or AT8, independently of signal intensity, to assess whether the cell cycle had started or arrested.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8469018	At high concentrations, JC-1 forms red fluorescent aggregates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "high", "concentrations", ",", "JC-1", "forms", "red", "fluorescent", "aggregates", "." ] } ]
PMC7570809	After 24 h of seeding, the cell monolayers were scratched linearly and incubated with the peptide RGDechi15D (50 μM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "24"...
PMC11730000	The samples were cultured in Ham’s medium F12 supplemented with 10% (v/v) fetal bovine serum and 1% (v/v) antibiotics (10000 U/mL penicillin and 50 mg/mL streptomycin).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300639	Additionally, in ccRCC, we confirmed that RNF26 mediates the degradation of CBX7, thereby promoting the proliferation of renal cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additio...
PMC8164677	The CI of < 1, = 1 and > 1 indicates synergism, additive and antagonistic effect in combined drug action, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5600151	PAMAM served as a siRNA complexing moiety and DOPE was used to create hydrophobic cores where small hydrophobic molecules, such as doxorubicin (DOX), were encapsulated .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8751435	Potential factors interpreting selectivity of caspase‐3 are needed to explain this phenomenon in CME‐induced pyroptosis (Ramirez et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Potential", ...
PMC11774251	RNA sequencing was performed by Beijing Novigen Technology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "sequencing", "was", "performed", "by", "Beijing", "Novigen", "Technology", "." ] } ]
PMC5600151	The same can be assumed for chemical conjugation since the number of modifiable surface groups that are used to conjugate the drugs is increased in high generations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The two seemingly contradictory functions appear to be segregated in two distinct subsets expressing T-bet or RORγt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "two", "seemingly", "contradictory", "funct...
PMC11087055	Throughout this work, the cell flows were recorded by tagging individual epiblast cells with electroporated fluorescent tracers at the pre-streak stage (Eyal-Giladi and Kochav, 1976).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	A minimum MAC of 5 was used when testing variants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "minimum", "MAC", "of", "5", "was", "used", "when", "testing", "variants", "." ] ...
PMC11423992	A10491-01, Gibco) containing 10% fetal bovine serum (FBS) (cat. #	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A10491", "-", "01", ",", "Gibco", ...
PMC11291490	Primary antibodies used included rabbit anti-E polyclonal antibody (prepared in this study, 1:1000) and rabbit anti-duCD40L polyclonal antibody (prepared in this study, 1:500), both diluted accordingly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10671321	At the end, four washes with PBS-tween 0.1% were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "end", ",", "four", "washes", "with", "PBS-tween", "0.1", "%",...
PMC9429973	However, the clinical significance of these mutations in large CLL cohorts and their presence in other B-cell neoplasms is unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...
PMC11352666	Treatment of adolescents and young adults with metastatic, relapsed or refractory EWS remains a challenge, and the therapies that are currently used have high potential for significant long-term toxicity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9509578	Treatment with the nanoformulation led to a reduction in tumor volume and inhibition of the activity of the MGMT enzyme in a majority of the cells and in a xenograft mouse model .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, because of their mechanism of action, NA are also potentially mutagenic to the genome of physiologically normal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "b...
PMC11545868	In apoptosis, survivin may function by inhibiting caspases, enzymes that play a central role in the initiation and execution of cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11471176	Carnosine, under scrutiny through MTT assays across diverse cell lines, unveiled disparate effects on % survival, as thoroughly documented in Table 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11337594

The p53 signalling pathway was markedly upregulated following TER treatment, leading to the activation of CASP3 via the intrinsic apoptotic pathway.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "p53",...

PMC9429973

At the diagnosis time RI is detected in 20-40% of patients, in 2-4% of patients with newly diagnosed MM develop dialysis-dependent RI, which is associated with early mortality and a high complications’ incidence.

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PMC10530622

Oxidative stress has been strongly associated with oxalate toxicity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oxidative", "stress", "has", "been", "strongly", "associated", "with", "oxalate", "toxicity", "." ] }...

PMC11723947

We isolated wild-type and Hp1g naive CD4 T cells and compared their activation and differentiation following T cell receptor engagement and exposure to Th1 or Th17 lineage-specifying factors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10165258

The results for D2 on spheroids cultured in 96-well plates are shown in Figure 4D and full results of these experiments are shown in Table 1.

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PMC11792090

Additionally, the apoptotic rate of CFSE-labeled cells after co-culture with E066 CAR-T cells was approximately 7%, slightly lower than the rate observed in cells co-cultured with P8F8 CAR-T cells ( Figure 1I ).

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PMC11412721

Gene expression (B, right) or survival curves (C) were plotted for the 30% patients (27 men, 20 women) with the highest or lowest ACKR4 expression, classified according to sex. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4485648

Such XRE-mediated response has been associated with SFN in several cell types (10).

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PMC11321678

Scores are normalized by the Z score.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scores", "are", "normalized", "by", "the", "Z", "score", "." ] } ]

PMC11467964

KCND3. (

[ { "tags": [ "O", "O", "O" ], "tokens": [ "KCND3", ".", "(" ] } ]

PMC11792888

When the scorpion venom is combined with etoposide, a well-known chemotherapeutic agent, it enhances the effect of both treatments.

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PMC11740573

Then, cultures were treated with thermally inactivated (autoclaved at 121 °C, 1.02 bar pressure, 15 min.)

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PMC10197932

Thus, these markers are essential for the functionality of lymphocytes, and mainly for CD8+ cytotoxic activities.

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PMC9429973

In addition, Casitas B-lineage Lymphoma mutations (CBL) are observed in 10% of pts with MDS/MPN and up to 13-15% of pts with CMML (mainly proliferative type).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Exclusion criteria were lack of information on comorbidities, survival or relapse status, or age <18 years.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exclusion", "criteria", "were", "...

PMC9429973

No differences were observed between both populations regarding basal characteristics.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "differences", "were", "observed", "between", "both", "populations", "regarding", "basal", ...

PMC9429973

CD34CD38CLL-1 cells were smaller in size than their CD34CD38CLL-1 counter-parts and represented approximately 2% of the entire CD34CD38 subset.

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PMC11350568

50 μM chlorpromazine was incubated with Cy5-AptG-1, Cy5-AptG-2, and Cy5-Sgc8c at the concentration of 500 nM for 2 h. Given the rapid internalization rate of AptG-1, we developed a keen interest in the pathways through which the TMPDS enters the cells.

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PMC11568601

A total of 16 expression trends were identified using STEM software (Supplementary Fig. S1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "16", "expression", "trends", ...

PMC10728200

The results showed that STUB1 knockdown effectively blocked the anti-tumor effect of IM and reduced the promotion of lipid-ROS mediated by IM (Fig. 3I, H).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

2.

[ { "tags": [ "O", "O" ], "tokens": [ "2", "." ] } ]

PMC11317131

The SP backbone was modified by replacing the gene VI promoter with the RecA promoter to decrease generation of recombinant wildtype M13 phage (Supplementary Figure S8b).

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PMC11429241

The first design, which we refer to as the basic scaffold, had cubic unit cells and was 500 × 500 × 250 m in overall size (Figure 3a).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6133382

Plates were incubated for 90 minutes with shaking and then washed 4 times with 0.05% Tween PBS using an automated plate washer.

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PMC11519077

The expression levels of the Collagen Type II gene in differentiated MSCs into the chondrocyte lineage were also shown to be considerably different from undifferentiated MSCs (Figure 4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9031474

In further experiments, it was shown that 75 inhibits DNA binding of the transcription factors NF-kB and Stat-3 to the survivin promoter.

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PMC11457557

DM and chronic hyperglycemia disrupt MiRNA expression in various tissues, impacting disease onset and progression.

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PMC11680049

The suspension culture was cultivated in 100 and 250 mL round and conical flasks on a shaker (CRYSTY) in the dark at a temperature of 23 ± 1 °C and a rotation speed of 100 rpm.

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PMC11012012

This downregulation was correlated with a reduction in Bcl-2 and Mcl-1 expression .

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PMC11674891

Ten five-week-old female nude mice (BALB/c-nude) were obtained from Orient Bio (Seongnam, Republic of Korea).

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PMC9429973

All 5 patients responded early to treatment, which became apparent immediately after the first dose of 2.5 mg.

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PMC11463018

For flow cytometry assay, annexin V-FITC/propidium iodide (PI) staining assay (A211-02, Vazyme) was employed to detect cells in early apoptotic and late apoptotic stages.

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PMC9910796

The arrowheads indicate representative labeling.

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PMC11733919

Box and whisker plots are shown, n = 3, ***p < 0.001, **p < 0.01, *p < 0.05 compared to senescence control (ANOVA and Dunnett’s a posteriori test), p < 0.001, p < 0.05 compared to 17-DMAG alone.

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PMC9429973

Overall, 22 proteins had significantly different expression in AA_DX samples (13 up, 9 down) compared to NC with AA_PROG and PGF having 8 (4 up, 4 down) and 14 (7 up, 7 down) respectively.

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PMC11394227

Cell count was performed with a cell counting apparatus (Thermo Fisher Scientific, Waltham, MA, USA), and the cell density reached 2 × 10 cells/mL or more, which was in the logarithmic growth stage.

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PMC5574817

The recombinant plasmid, pCMV6-Neo-hERG was sent for DNA sequencing at Macrogen (Seoul, Korea).

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PMC8839885

Briefly, total RNA was extracted from the cells using Tri Reagent (Sigma).

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PMC11704834

no. RPN2232; Cytiva), and band intensities were quantified by densitometric analysis using ImageJ software (National Institutes of Health).

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PMC6461034

Centrifuge at 2,000 × g for 30 s at 4°C to pellet the beads.

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PMC11593084

All cell lines were cultured at 37 °C in a humidified atmosphere with 5% CO2 and 95% air.

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PMC9429973

Approximately 250 patients will be randomized 1:1.

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PMC8348645

There was a significant effect of different samples present at p < 0.05 level.

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PMC10698968

For 3D aggregate culture, cells were seeded at 600 cell/ml density in ultra-low attachment 6-well plates (Corning inc) in 2 ml of complete medium.

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PMC11609529

These fusions are potent oncogenic drivers, representing critical targets for both diagnostic and therapeutic interventions.

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PMC9429973

In this cohort, concurrent use of HCTZ and BB showed a significant trend for a lower BP [Est -5.05; 95% (-10.0, -0.06); p= 0.04].

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PMC9429973

M. Welslau, B. Kubuschok, J. Topaly, B. Otremba, T. Wolff, G. Bryn Department of Oncology, Klinikum Aschaffenburg, Aschaffenburg; Department of Hematology/Oncology, Augsburg University Medical Center, Augsburg; Klinik für Hämatologie und Onkologie, CaritasKlinikum Saarbrücken, Saarbrücken; Onkologische Praxis Oldenburg...

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PMC11001582

Graph, mean ± s.e.m.;

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PMC7602170

Rapamycin, an mTOR inhibitor and autophagy inducer, enhanced autophagy activity, downregulated the expression of KIT, and led to apoptosis in GIST430 and GIST48 cell lines .

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PMC9509578

Such micellar nanomaterials have prolonged circulation time and accumulate in tumor tissues via the EPR mechanism .Table 3Nanomicelles and nanoemulsions used to overcome cancer MDRS.

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PMC9429973

Median duration of therapy (DOT) was estimated using the Kaplan-Meier method.

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PMC8584666

Therefore, the ratio of the amounts of GSH and GSSG was measured.

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PMC11377827

Mean ± sd.

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PMC11637820

Among these different bacteria, Staphylococcus aureus and Pseudomonas aeruginosa were found to be two of the most dominant gram-positive and gram-negative species, respectively, appearing in almost all ulcers.

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PMC11487720

The full-length ECFP-TRAF2 was not expressed and did not inhibit BCD.

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PMC7709199

Other less conservative substitutions of the asparagine, or targeting the Ser/Thr site that is part of the NG motif, will also disrupt the glycosylation of a specific site.

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PMC6799808

Notably, CDK1 and CDK2 were not obviously affected by GLPT treatment, despite a slight inhibitory effect of 2 mg/ml GLPT on cyclin A/E expression in A549 cells (Fig. 2c).

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PMC11095939

Figure 2—figure supplement 1.Modulation of Mecp2 expression in the mouse liver.(A) Schematic diagram of loss of Mecp2 in mouse hepatocyte.

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PMC10506676

In this way, E2F enters the cell nucleus and transcribes genes related to the proliferative phase of the cell cycle, so the infected cell goes from G1 to the S-phase and continues to multiply (5).

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PMC11462673

A The knockdown levels of LDB1 in cells was verified by WB.

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PMC11661024

Long-term studies on the impact of extended exposure to postbiotics and the potential development of resistance in cancer cells will be helpful before concluding clinical potential.

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PMC6901583

The Buffy coats from healthy voluteers were used to isolate human monocytes.

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PMC11470999

Spontaneous brain metastasis from a primary tumor is ideal as it allows for the study of all steps of the metastatic cascade and is simple to establish.

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PMC6600253

Because of its specific selective binding to G-quadruplexes, telomestatin can lead to telomere degradation and induce delayed senescence and apoptosis in various types of cancer cells, such as leukemia, neuroblastoma, and cervical cancer cells, while having minimum effects on normal cells.

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PMC11543885

Figure 3Capture and biotinylation of ASC in HEK293 cells stably expressing Flag-NLRP3-APEX2(A) Schematic overview of the experimental design for treatment conditions and APEX2 induced biotinylation.

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PMC10495912

On the other hand, TQ (75 µM) was able to decrease the IC50 of hydrogen peroxide by 48.2 µM (Figure 1-C).

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PMC11655498

EBV reactivation involves crosstalk between various factors and signaling pathways, and the subsequent complicated virus-host interplays determine whether EBV continues to propagate.

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PMC11697065

Due to the averaging effect of the heterogeneity of the cell pools both transcriptomic and proteomic analyses resulted in a limited number of significantly differentially expressed genes or proteins that could be used for pathway analysis (Supplementary Figure 2A).

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PMC11746942

Src inhibition by Tri blocked S1PR3-induced early and prolonged STAT3 activation.

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PMC11740207

One of the most widely used AML cell lines with confirmed LSLCs is HL60, which was derived through leukapheresis from the peripheral blood of a 36-year-old patient with AML (Collins, 1987).

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PMC4485648

For the proliferation assay, 4×10 A2780 ovarian cancer cells and their chemoresistant variants were seeded into each well of an E-plate 16 (Roche) in DMEM containing 5 μM sulforaphane or DMSO (control samples).

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PMC9739791

Phorbiplatin 8 showed little to no toxicity in the dark on various cell lines (Table 3).

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PMC8009078

A cut-off of 8 Å was considered for the short-range nonbonded interaction, while the particle mesh Ewald method was used for the long-range electrostatics.

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PMC11361748

Scale bars: 10 μm.

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PMC10831439

The effect of checkpoint inhibition through nivolumab was analyzed in these settings.

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PMC11726183

It is noteworthy that compound 23 with nitro substitution attached to the para position of the phenyl ring is the top contender of the entire library of compounds displaying an IC50 value of 15.8 ± 0.6 μM. It shows the importance of the electron-withdrawing group in inhibiting cancer cells.

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PMC11740207

In contrast, LT-HSCs and USSCs are more specialized towards specific lineages (hematopoietic and mesenchymal, respectively), making them less comparable to VSELSCs in terms of versatility (Ratajczak et al., 2012; Alanazi et al., 2023; Velasco et al., 2023).

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PMC11438317

The 1854C > T polymorphism changes Arg620 by a Trp in the P1 Pro rich motif (PRM) found at the C-terminus of LYP.

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PMC11644761

The intensity of the fluorescent signal was not analyzed, as our aim was to determine the number of cells with Ki67 or AT8, independently of signal intensity, to assess whether the cell cycle had started or arrested.

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PMC8469018

At high concentrations, JC-1 forms red fluorescent aggregates.

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PMC7570809

After 24 h of seeding, the cell monolayers were scratched linearly and incubated with the peptide RGDechi15D (50 μM).

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PMC11730000

The samples were cultured in Ham’s medium F12 supplemented with 10% (v/v) fetal bovine serum and 1% (v/v) antibiotics (10000 U/mL penicillin and 50 mg/mL streptomycin).

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PMC11300639

Additionally, in ccRCC, we confirmed that RNF26 mediates the degradation of CBX7, thereby promoting the proliferation of renal cancer cells .

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PMC8164677

The CI of < 1, = 1 and > 1 indicates synergism, additive and antagonistic effect in combined drug action, respectively.

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PMC5600151

PAMAM served as a siRNA complexing moiety and DOPE was used to create hydrophobic cores where small hydrophobic molecules, such as doxorubicin (DOX), were encapsulated .

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PMC8751435

Potential factors interpreting selectivity of caspase‐3 are needed to explain this phenomenon in CME‐induced pyroptosis (Ramirez et al., 2018).

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PMC11774251

RNA sequencing was performed by Beijing Novigen Technology.

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PMC5600151

The same can be assumed for chemical conjugation since the number of modifiable surface groups that are used to conjugate the drugs is increased in high generations .

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PMC9429973

The two seemingly contradictory functions appear to be segregated in two distinct subsets expressing T-bet or RORγt.

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PMC11087055

Throughout this work, the cell flows were recorded by tagging individual epiblast cells with electroporated fluorescent tracers at the pre-streak stage (Eyal-Giladi and Kochav, 1976).

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PMC11538390

A minimum MAC of 5 was used when testing variants.

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PMC11423992

A10491-01, Gibco) containing 10% fetal bovine serum (FBS) (cat. #

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PMC11291490

Primary antibodies used included rabbit anti-E polyclonal antibody (prepared in this study, 1:1000) and rabbit anti-duCD40L polyclonal antibody (prepared in this study, 1:500), both diluted accordingly.

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PMC10671321

At the end, four washes with PBS-tween 0.1% were performed.

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PMC9429973

However, the clinical significance of these mutations in large CLL cohorts and their presence in other B-cell neoplasms is unknown.

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PMC11352666

Treatment of adolescents and young adults with metastatic, relapsed or refractory EWS remains a challenge, and the therapies that are currently used have high potential for significant long-term toxicity .

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PMC9509578

Treatment with the nanoformulation led to a reduction in tumor volume and inhibition of the activity of the MGMT enzyme in a majority of the cells and in a xenograft mouse model .

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PMC9429973

However, because of their mechanism of action, NA are also potentially mutagenic to the genome of physiologically normal cells.

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PMC11545868

In apoptosis, survivin may function by inhibiting caspases, enzymes that play a central role in the initiation and execution of cell death.

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PMC11471176

Carnosine, under scrutiny through MTT assays across diverse cell lines, unveiled disparate effects on % survival, as thoroughly documented in Table 3.

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