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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
All statistical tests were two-tailed with the significance level set at α=0,05.
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PMC11607764
The survival curve includes (A) overall survival and (B) disease-free survival.
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PMC11637284
Moreover, the p166-TAC60 interaction serves as a rare example of a permanent contact site between the IM and OM .
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PMC11634027
Scale bar: 10 µm. (
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PMC11672881
The GO analysis showed enhanced apoptosis, while the metabolomic data revealed disruptions in tryptophan metabolism, glycerophospholipid metabolism, and sphingolipid metabolism, which are vital for cellular energy production and biosynthesis.
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PMC11674891
RC-3095, a synthetic peptide shown to inhibit GRPR activation , and PD176252, a potent non-peptide GRPR antagonist , were used in these experiments (Figure 3a,b).
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PMC7171147
To further validate whether COL11A1 increases the FAO rate in ovarian cancer cells, we supplemented a long-chain fatty acid substrate, palmitate, to ES2 cells cultured on COL11A1 extract, and measured OCR using the Seahorse XF analyzer.
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PMC11540664
A low peripheral blood lymphocyte count suggests a preexisting immunosuppressive state, resulting in an inadequate tumor immune response (12–14).
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PMC11306331
Biomolecular condensates form as a result of many weak, multivalent interactions, leading to co-assembly of proteins and/or nucleic acids into a dense phase containing a high concentration of the condensed components surrounded by a dilute phase.
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PMC9918897
It is important to point out that the alcohol concentration of all the drinks from each of the 4 groups was the same (final concentration 6.5 V%).
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PMC11045125
Cells were cultured with media changes as needed, until uninfected cultures died out, with addition of fresh irradiated YK6-CD40lg-IL21 as needed.
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PMC10605143
In turn, MCF12A cells with reduced expression of HSF1 were characterized by a stronger expression of CDH1 in cell–cell contacts within the formed acini compared to control cells (Figure 3f).
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PMC11092382
Additionally, sophocarpine also has an anti-nonalcoholic steatohepatitis effect (Song et al., 2011), and the mechanism may involve the activation of the AMPK signaling pathway (Song et al., 2013).
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PMC11746948
The palmitoylation level of GPX4 was nearly abolished when C66 was mutated, and mildly reduced with a C75 mutation (Fig. 2i, j and Supplementary Fig. 6b, c).
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PMC11266100
In the matter of buffer ionic composition, it is noted that divalent cations such as Ca and Mg are necessary for the formation of DNA–membrane complex during the PEFs application.
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PMC9504875
In contrast, to date, NSs of CCHFV (Nairoviridae) have not been reported to be an IFN antagonist, although it induces apoptotic cell death .
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PMC7802142
They can deliver internal prolific proteins, mRNAs and microRNAs into target cells and are well tolerated by the body .
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PMC11750165
Mixture of synthetic mRNA of Cas9 (250 ng/μL) and 50 ng/μL sgRNA (5’-GAC AGT CTG CAC TAA CAT ATG G-3’) was injected into fertilized eggs.
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PMC9919300
Catania, Italy).
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PMC10213179
To remove unbound and surface-bound aptamers, target cells were washed with ice-cold DPBS adjusted to 0.5M NaCl (high-salt wash) for 5 min, ensuring that the recovered RNA corresponded to the fraction that was internalized.
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PMC9813422
Long-lasting infections with high-risk HPVs can develop cancer in areas where HPV infects cells, such as the cervix and oropharynx.
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PMC11626627
Moreover, the group with simultaneous knockdown of ERβ and TWIST1 had smaller tumors compared to the ERβ knockdown group alone (Fig. 6A).
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PMC6835428
In several tumors, including OC, different components of the angiogenic pathway have been targeted with different therapeutic molecules .
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PMC11597167
Overall, while there is substantial evidence supporting the potential of quercetin, gallic acid, 3-hydroxytyrosol, oleuropein, rosmarinic acid, and EGCG in modulating various genes and pathways relevant to AD, further research is needed to fully elucidate their therapeutic potential through other mechanisms of action.
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PMC11365983
Statistical analysis: boxplots—Dunn’s (post hoc Kruskal–Wallis) test; barplots—Tukey HSD post hoc one-way ANOVA].
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PMC9351137
Scale bar = 10 μm The aforementioned results suggested that BAF53a and Tip60 may contribute to the recruitment of cytokinesis regulators to the midbody, with a role in the regulatory pathway that controls the final step of cytokinesis.
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PMC9164404
Abplatin was believed to be reduced by intracellular reducing agents such as glutathione (GSH) and ascorbic acid to release Pt(II) for DNA binding .
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PMC7812570
The expression levels were assessed by measuring the relative cell counts (A) and the fluorescence intensity (B) Effects of GPI-anchored antibodies on the expression of HIV receptors.
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PMC11585254
Amino acid sequence of the CXCR5 carboxyl-terminal tail (CT).
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PMC7812570
In brief, cells were lysed in ice-cold RIPA buffer (Invitrogen) containing protease inhibitors (Roche) to isolate proteins.
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PMC9429973
It was more evident after consolidation, with statistically significant impact in OS and RFS.
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PMC11612315
Schematic illustration of the analgesic effect through systemic GLP-1 secretion (f) and local GLP-1 induction (g).
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PMC11055510
Xenograft nude mices of each group are displayed (n = 8). (
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PMC11727062
Current mainstays of melanoma treatment include surgery, radiotherapy, immunotherapy, and targeted therapy.
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PMC5833712
Results are expressed as mean ± s.d.
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PMC6643347
IC50 is the 50% inhibitory concentration (causing 50% suppression of the infection); CC50 is the 50% cytotoxic concentration (causing loss of viability in 50% of cells); SI is the selectivity index calculated as the ratio between CC50 and IC50.
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PMC11755624
The expression of CDC6 is regulated by IL-22, one of the important cytokines implicated in the pathogenesis of psoriasis .
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PMC11747467
Therefore, we speculated that STAT3 inhibitors also could also enhance RC48 efficacy against basal bladder cancer.
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PMC9019892
Finally, a FACS Calibur flow cytometer (BD Biosciences) was used to test the cell cycle distribution.
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PMC9429973
This analysis includes pts with EBV PTLD following HCT who were refractory or relapsed after rituximab ± CT as first line of therapy.
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PMC11738017
Figure created with BioRender.com. (
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PMC9927933
UBE2C coupled with CDH1 to promote DEPTOR ubiquitylation and degradation.
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PMC2196094
Therefore, we decided to use the mucosal MC line RBL-1 as a source of mRNA for the isolation of rat mucosal MC proteases.
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PMC10178190
In addition to MSCs, adipocytes have also been reported to protect tumor cells from the effect of anticancer agents .
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PMC11763111
Additionally, CD47 molecules have been shown to inhibit macrophage-mediated rejection, while conventional HLA-E/HLA-G molecules can mediate anti-NK rejection effects.
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PMC11257203
The donor had not been exposed to any chemicals or ionizing radiation that might have interfered with the results of the test throughout the six months prior to the blood sampling.
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PMC10040136
Based on the above results, we prepared the above 24 paired samples into single cell suspensions, which were then separated by FACS and the proportion of MSC(CD73CD90CD105 / CD45) cells to the total cells was calculated.
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PMC8751435
Specifically, nicotinic acid is stimuli for generating ROS and exerting cytotoxicity as well (Lehmler et al., 2008), indicating it may be one of responsive component for inducing pyroptosis.
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PMC9118379
When adopting the CMSe strategy, using gFDR can obtain more variant PSMs than using cFDR.
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PMC11731161
In contrast, SEL induced a significant accumulation of RanBP1 in the nucleus.
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PMC11334037
IGF2 expression was high in drug-resistant GIST cell lines, suggesting that IGF2 overexpression may be closely related to drug resistance.
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PMC10759659
A total of 150 patients, with 15 (10%) from the ARID1A deficient group, were divided into two groups following the previously described standards.
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PMC9429973
The cumulative incidence of MMR and MR4 was 32.6% (20.9-44.8%) and 15.9% (7.9-26.3%) at 12 mo.
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PMC11752740
BTZ disrupts this process, allowing these proteins to function effectively and promote cancer cell death [14–16].
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PMC9429973
DFS was significantly better in patients achieving a molecular response upon induction than in those who did not (100% vs 67%, p=0.016, Fig. 1A), with no events recorded in the group of complete molecular responders and positive-not-quantifiable cases.
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PMC11628904
Thus, we first decided to photoconvert only cells in the region of tissue immediately affected by burn, referred to here as zone 1 to determine their fate as burn injury progresses (Figure 2A,B).
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PMC11461874
Relative bioluminescence rhythms are shown as mean± SEM (n = 3).
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PMC11802929
Fig. 3Three peptide groups distinguished by sequence physicochemical properties.a All 951 putative SARS-CoV-2 peptides for HLA-A*02:01 are encoded by the physicochemical properties of amino acids at each position for unsupervised clustering.
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PMC8193046
Virtual screening was performed with the ENAMINE REAL drug-like® compound library consisting of 15,547,091 molecules and a set of 1,505 molecule as potential broad-spectrum ABCB1, ABCC1, and ABCG2 inhibitors resulted, from which compounds 7–11 were discovered.
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PMC9341513
We found that, in general, interactions between the gene and the Eµ enhancer are weaker if their genomic separation is larger.
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PMC7823217
In addition to the overall response, drug efficacy can also vary considerably even across different regions of the tumor .
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PMC11792090
Compared to mock CAR-T, UCAR-T, and CD47 UCAR-T cells, the number of SAP UCAR-T cells in the blood was significantly higher, indicating reduced HVG reactions and enhanced persistence ( Figure 4L ).
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PMC11587606
In 3D cultures of MCF10A/RH cells, CRT0066854 treatment led to enhanced expression of both E-cadherin and Occludin, but not ZO-1 (Fig. 3E), despite of diminished RHBDF1 levels.
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PMC9429973
Contrived DNA panels were prepared by diluting DNA from either cell lines or clinical BM samples (ALL, CLL, MM and MCL) into DNA from healthy BM samples.
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PMC11279598
The current findings further provide evidence that orally administered MH has antitumor activity in stopping the progression of human breast tumor xenografts implanted in nude mouse models in vivo.
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PMC8481254
D Tumor sizes were monitored in mice for 42 days after subcutaneous injection of Bel-7404 cells.
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PMC11794588
A silica gel was used to bind the plant extract, and a silica column was made.
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PMC11515150
ELISA data showing the release of IFN-γ by NT-NK cells and CD5 CAR-NK cells after co-incubation with target cells overnight (n = 3; *p < 0.05) (right panel).
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PMC11701801
SWI/SNF-proficient (n = 1,238), SMARCB1-deficient (n = 19), ARID1A-deficient (n = 52), PBRM1-deficient (n = 23), SMARCA4-deficient (n = 34), SMARCA2-deficient (n = 27), SMARCA4/SMARCA2-deficient (n = 6), and SS18–SSX (n = 5) cell lines were analyzed, and data are presented as the mean ± SEM.
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PMC11802929
Our phenotype assignment based on transcriptomics (as the reviewer mentioned for Main Figs. 4 and 5) can be validated by surface protein expression (measured by scCITE-seq).
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PMC11721096
Finally, the inhibitors present in A. sparsifolia and C. arabica were screened by this method, and their chemical structures were identified by NMR, HPLC-MS, or GC-MS techniques.
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PMC11532793
A nominal FDR cutoff of 0.05 was used for the DE analyses.
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PMC8270637
In addition, microscopic observation of the clone shape revealed that SMMC-7721 cells co-cultured with unactivated T cells formed approximately round, complete clones; SMMC-7721 cells co-cultured with activated T cells formed irregular clones.
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PMC11228511
Representative confocal fluorescence microscopy images of wild-type SMCs (WT) and SMCs expressing hu-progerin, hu-prelamin A, and hu-progerin-SSIM.
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PMC11621493
These observations suggest that PLA2G4D exhibits MAG:MAG and, at a lower rate, MAG:DAG or DAG:DAG acyltransferase activity (MMAT, MDAT, and DDAT activity, respectively).Fig.
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PMC7452526
The IC50 of CN–Ag was calculated using linear regression for a dose-dependent curve that obtained the effect of different concentrations of silver nanoparticles on Caco-2 cell line as showed in Figure 7.
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PMC9684669
Using qHTCS, this work found a group of doxorubicin potentiators in an ABCB1-mediated MDR ovarian cancer cell line.
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PMC11770130
All the lipidomics.
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PMC10213179
RNA interference therapeutics represent a fundamentally new avenues to treat human disease by addressing targets that are otherwise “undruggable.”
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PMC10297204
However, when major neurovascular tissues are located close to the tumors, sacrifice with these tissues leads to severe functional impairment of the affected limbs.
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PMC11419566
The combination of PA with radiotherapy has been shown to have a therapeutic effect on GC.
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PMC8592717
Recently, PCA and PAL have been confirmed to have antioxidant effects in many diseases, making these “old compounds” a potential “new application” for medical therapies.
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PMC11594588
These include 1,N-propanodeoxyguanine (PdG) and etheno DNA adducts, such as 1,N-ethenoadenine (1,N-εA), 3,N-ethenocytosine (3,N-εC), N,3-ethenoguanine (N,3-εG), and 1,N-ethenoguanine (1,N-εG).
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PMC11240052
Upregulation of circ-0008285 in ovarian cancer tissues and cell lines. (
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PMC11731161
As expected, SEL significantly accelerated the degradation rate of XPO1 in MM cells (Fig. 1C).Fig.
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PMC9878562
Scatter plots of directionality vs arrest coefficients of 1000 VAL-wt mixed, VAL-ko alone, VAL-ko mixed.
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PMC9429973
The percentage of loss of MFI were higher in the CD38 ME group (-36,32%) than in the CD38 nanobody group (-0,35%).
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PMC5811757
A previous study showed there was no correlation between MDR1 mRNA expression and disease progression in patients with osteosarcoma (27).
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PMC11699465
We uncovered the nuclear localization of TMEM199.
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PMC11806613
E-G Effects of LRP8 overexpression on OST-01-induced ferroptosis and TNBC cell growth inhibition.
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PMC11388384
State transitions diagram.
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PMC11015054
mRNA expression of METTL5 in LO2 MHCC‐97H, SMMC‐7721, and HepG2; (B, C) Protein expression of METTL5 in LO2 MHCC‐97H, SMMC‐7721, and HepG2; (D–I) Detection of METTL5 mRNA and protein expression in SMMC‐7721/HepG2 cells by qRT‐PCR and western blot. **
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PMC11779993
Treatment with SPEE at concentrations of 0–250 μg/mL for 24, 48, and 72 h did not cause any cytotoxic effect against keratinocyte HaCaT cells.
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PMC11590870
For example, cellular antioxidant activity is a biologically representative method .
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PMC11791432
In this study, we integrated extensive transcriptome profiling as well as single-cell sequencing data to systematically examine the role of ANXA1 in gliomas.
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PMC10631132
This increase was observed in both iPSC lines.
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PMC9220170
In addition, SELENOM overexpression in HT22 and C8-D1A cells increases the cytosolic calcium concentration in response to oxidative stress and may be involved in the regulation of apoptosis by blocking or delaying it .
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PMC11486946
100 μL of 120 nM EGF was added to every well (final concentration, 60 nM).
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PMC11216402
The low ATAC signal in Mes-like cell lines at GATA6_E2 is consistent with the upregulation of the repressor ZEB1 and downregulation of GATA6.
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PMC6889484
Puromycin-resistant pools of 293T cells transduced with A3x3G(DK) virus were analyzed for the deletion frequency of the A3G-D128K ~900-bp direct repeat.
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