OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11727000	The resulting construct, as well as a control expressing the BioiD ligase alone, was cloned into the pTSIN lentivirus expression vector, and SH-SY5Y neuroblastoma were transduced to produce polyclonal stable pools.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC9727330	Cytotoxic concentration 50% (CC50) The Asp and NNDAsp were tested for their anticancer properties and calculated the potential CC50 in Caco-2 and NCM-460 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLin...
PMC11248911	The promising derivative arrested cell growth at the G1 phase inducing early and late apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "promising", "derivative", "arrested", "cell", "growth", ...
PMC11411131	Ornithine decarboxylase (odc), a target for proteasome degradation, was expected to suppress luciferase activity under full-length protein expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ornithine", ...
PMC11751675	Based on these findings, the authors proposed that sesquiterpene lactones (SLTs) with structural similarities to brevilin A hold promise as potential anti-influenza agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11746942	To explore the consequences of S1P in psoriasis pathogenesis and the potential therapeutic relevance of modulating S1P receptors, we utilized FTY720, a pan-S1PR modulator approved for the treatment of multiple sclerosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	Hanks’ balanced salt solution, William’s medium E containing L-glutamine (WME), and the bicinchoninic acid protein assay kit were obtained from Thermo Fisher Scientific (Waltham, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506670	It acts as a molecular switch that cycles between an active, GTP (guanosine triphosphate)-bound state, and an inactive, GDP (guanosine diphosphate)-bound state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Antiepileptic, antihypertensive, and supportive therapy were initiated just after PRES.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antiepileptic", ",", "antihypertensive", ",", "and", "supportive", "therapy", "were", ...
PMC11732628	The cells were incubated in Dulbecco’s Modified Eagle Medium (DMEM; Gibco; Thermo Fisher Scientific, Inc., Shanghai, China) supplemented with 10% fetal bovine serum (FBS; Gibco; Thermo Fisher Scientific, Inc.) at 37 ℃ in a humidified atmosphere containing 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	The next largest change is for LTO1 which shows an ∼9.8-fold increase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "next", "largest", "change", "is", "for", "LTO1", "which", "shows", ...
PMC11706491	Boxplots (B) represent quartile distribution with outliers depicted as dots and table (D) shows mean ± standard deviation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Boxplots", "...
PMC9454852	BOLD-100 causes an increase of ROS as a consequence of the induction of ERO1α overexpression; The rise in ROS and ERO1α levels destabilize ER calcium regulation, leading to a massive release into the cytosol either through TLC and IP3R leakage, but also a Ca overload into the mitochondria by way of MAM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11277157	We have not challenged the cells with an oxidative stimulus , and, as anticipated, no sign of cytotoxicity following siRNAs was observed, which argues for uninterrupted mitochondrial homeostasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765678	MD simulations could also provide insights into the stability of Erastin’s binding under physiological conditions, revealing conformational changes in P-gp and BCRP upon ligand binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3164356	Receptors for other viruses like HIV and hepatitis B virus (HBV) are either missing in the CHO-K1 genome or lacking expression in the transcriptome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In control group early RR was higher if pts had DEL (57.1%(12/21) DEL+ vs 16.1%(5/31) DEL-, p=0.003) or EA (75%(3/4) EA+ vs 24.2%(16/66) EA-, p=0.041).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756514	Although WTA is a highly abundant glycopolymer on the surface of S. aureus, a range of different surface molecules could be candidates for this additional ligand.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11666785	In the first experiment, Dendra2-Actin plasmid DNA was used to transfect NIH3T3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "the", "first", "experiment", ",", "Dendra2-Actin", "pla...
PMC4659567	for RuCl2C17H18N2BrI: C, 32.46; H, 2.88; N, 4.45; found: C, 32.24; H, 2.77; N, 4.22%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676670	At the same time, we noticed the upregulation of SNAIL, one of the major transcription factors related to epithelial–mesenchymal transition (EMT), which may suggest that this cell line is in a transitional state and could be prone to partial EMT changes under specific conditions, thus expressing an increase in cellular...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11709639	Observing reduced MCUB expression in AD, we used 5xFAD mutant mice with neuronal‐specific MCUB overexpression to assess age‐associated changes in cognitive function, neuropathology, and mitochondrial bioenergetics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	RNA was stained with SYTO 12 Green-Fluorescent Nucleic Acid Stain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "stained", "with", "SYTO", "12", "Green-Fluorescent", "Nucleic", "Acid", "Stain", ...
PMC9429973	This real-world study suggests that there is an unmet need in addressing anemia burden with ESAs, and novel and effective treatments are needed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11544771	In line with this, the combined treatment induced more apoptosis than either single treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "line", "with", "this", ",", "the", "combined", ...
PMC9966931	The indicator of cytotoxicity (potential anticancer effects) is an LC50 value less than 1000 µg/mL. The EO-based hybrid molecules developed here exhibited a strong correlation between their toxicity against A. salina and their structural features.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11560255	However, further in vitro and in vivo research is required to improve the findings of this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "further", "in", "vitro...
PMC10818062	These observations indicate a new mode of inter-relationship where the metabolic states of two different lipids are reciprocally influenced via their lipid countertransport.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These",...
PMC11789597	mRNA expression of SLC1A5 and SLC7A5 in MM1S cells expressing shNC or shCAV1 was determined using qRT‐PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mRNA", "expression", "of", "SLC1A5", "an...
PMC11591794	Accordingly, 1% mercaptoethanol was added to the lysis solution included in the kit, the medium was removed, and 1 mL of this solution was placed in each 25-mL flask washed with D-PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680982	Fig. 6Neratinib enhances the efficacy of CDK4/6 inhibitor combined with endocrine therapy by reducing HER2 mRNA stability through the interaction of HER2’s 3’-UTR region with hsa-miR-23a-5p. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11361748	Volcano plots highlighting genes that are up- or down-regulated by 8-fold or more (adj.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcano", "plots", "highlighting", "genes", "that", "are", ...
PMC9429973	In the overall population (2011-2021), the majority of patients had received 1L treatment with bendamustine-rituximab (BR, 53.9%), rituximab plus other regimens (27.6%), or rituximab monotherapy (11.2%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	With the exception of KCNA5 (Figure S1D), the expression of the other Kv1-encoding genes is not significantly correlated with survival in ES patients (Figures S1A-S1G, lower panels).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11085211	Another study demonstrated that the pyrogallol moiety in polyphenols had an important role to play in apoptosis induction in human embryonic kidney cells (HEK293T) and the chronic myelogenous leukemia cell line (K562), even though the mechanism was not investigated .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLin...
PMC9429973	To test this, we measured the effects of LF/IFPRLR knockdown on B cells in vivo in transgenic mouse models of SLE (Stage 1/ Aim 1), DLBCL (Stage 2/ Aim 2), and in vitro in malignant human B cells (Stage 3/ Aim 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	There have been difficulties with the development of clinical studies due to the poor pharmacological profile of β3-AR blockers and the limitation on the understanding of β3-AR functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In VIALE-A, median duration of response (mDOR) for CR/CRi (95% CI) was not reached (NR; 17.5−NR) and was 12.9 mo (7.9−17.3) in the Ven+Aza+G-CSF and Ven+Aza+non-G-CSF groups, respectively (Table); DOR at 12 mo was 67% and 53%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670954	However, the mechanisms by which BA protects the intestinal mucosal barrier remain to be elucidated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "mechanisms", "by", "which", ...
PMC11423992	TFAB002s bind to both CD20-expressing tumor cells and CD3ε-expressing T cells, causing crosslinking between T cells and tumor cells, which leads to T-cell activation, tumor cell lysis, and subsequent secretion of cytokines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10847511	Secondly, the in vitro drug screening assays examined in the cell line databases evaluated drug response over a very short period of 3–5 days, which is considerably shorter than the assessment of efficacy in vivo or in clinical tumors, where it is usually assessed on a weekly or monthly basis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	71 IgD MM patients received induction therapy based on ‘novel therapies’, 26 on ‘traditional therapies’.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "71", "IgD", "MM", "pat...
PMC11766309	Furthermore, in terms of OS, there was a negative correlation between a high expression of YKT6 and a longer life expectancy, and a K‒M plot was used to further analyze the correlation between YKT6 expression and prognosis in various cancers, including ACC, BLCA, CESC, HNSC, LGG, LIHC, LUAD, MESO, and UVM (Figure 4B–J)...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We hypothesized that spectral Flow-MRD allows for monitoring leukemic disease burden with unprecedented resolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "hypothesized", "that", "spectral", "Flow-MRD", "allows", "for", ...
PMC10440586	Since TAMs produce low levels of pro-inflammatory cytokines and lack T-cell co-stimulation factors, causing T-cell exclusion which facilitates tumor escape from immunosurveillance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since",...
PMC10218459	Exposure to CPP for 20 s led to a complete inhibition of cell growth (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exposure", "to", "CPP", "for", "20", ...
PMC11764090	The influence of cold stress depends on the status of plant cellular morphology (e.g., membranes and organelles) , biochemistry (e.g., enzyme activity) , physiological functioning (e.g., gas exchange and water management) , and phenology (e.g., developmental stages) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367146	The MD simulation was performed for high ranked docked complex, i.e. for three selected apoproteins (BCL2, ESR1 and MMP9) and their interaction with two lead compounds, daucosterol and gigantol, over a duration of 100 ns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11412752	The reduced cellular viability observed in HepG2 cells following STING deletion aligns with recent research, which suggests that the cGAS-STING pathway drives the survival of chromosomally instable cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	The mRNA levels of DBP normalized by ACTB are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mRNA", "levels", "of", "DBP", "normalized", "by", "ACTB", "are", "shown", "." ]...
PMC9429973	A transcriptional signature was associated with more durable ide-cel responses, which we postulate may outline a distinct suboptimal pretreatment feature in an ide-cel context; further exploration of this preliminary signal is ongoing. **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6617630	Bar represents mean ± SD from three separate experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "represents", "mean", "±", "SD", "from", "three", "separate", "experiments", "." ] } ]
PMC8753818	In this assay each experiment was repeated 3 times and n = 3, (: > 0.05, : > 0.01, : > 0.001, **: > 0.0001)Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	IPTOs from three HLA-A*02 patients were treated with TCR-T and interrogated by scRNA-seq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IPTOs", "from", "three", "HLA-A*02", "patients", "were", "treated", "with",...
PMC11295144	Fluorescent imaging was done using Zeiss 700 confocal microscope at 63 × magnification with image size 1,024 × 1,024.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescent", "imaging", "was", "...
PMC10669128	Nonetheless, not all the therapeutic approaches can be tested in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ",", "not", "all", "the", "therapeutic", "approaches", "can", "be"...
PMC9429973	Comparison of physician characteristics between the HMA non-prescribing vs HMA prescribing groups did not show significant differences in terms of age (54.5 vs 52.2 years; p=0.13), sex (69.7 vs 75.6% male; p=0.34), specialty (hematologist/oncologist, 90.5 vs 86.8; p=0.58), years since graduation (28.2 vs 25.4 years; p=...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742290	In the presence of R-spondin (RSPO), LGR5 binds to RSPO, RNF43/ZNRF3 is neutralized, and intracellular β-catenin is accumulated and increased, leading to enhanced activation of the WNT signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11568601	CHOP antibody (No. 15204-1-AP) was acquired from Proteintech Group, Inc. (Wuhan, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHOP", "antibody", "(", ...
PMC11665584	Finally, PITX1 enhanced full-thickness cutaneous wound healing by promoting keratinocyte migration and stimulating a neutrophil-spearheaded immune response into the wound bed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",...
PMC11476004	Some tumours are more common in large breeds of dogs: St. Bernard, Doberman, Golden Retriever, Boxer, and German Shepherd .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11409031	The primary reason for this high fatality rate is the late detection of the majority of cases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "reason", "for", "this", "...
PMC7987994	However, for degradable materials, these ratios are inappropriate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "for", "degradable", "materials", ",", "these", "ratios", "are", "inappropriate",...
PMC10092581	In addition, TEM analyses were performed on H157 cells after 24 h treatment with IC50 concentrations of the representative complexes [AuCl] and [AgCl] as well as of auranofin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988808	F Apoptosis assays and the relative quantitative results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "Apoptosis", "assays", "and", "the", "relative", "quantitative", "results", "." ] } ]
PMC11742047	Fig. 2Cell apoptosis and necrosis in HL-60 and K-562.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O" ], "tokens": [ "Fig.", "2Cell", "apoptosis", "and", "necrosis", "in", "HL-60", "and", "K-562", "." ] ...
PMC11730311	Next, we compared metabolites derived from the lipidated hαCGRP8-37 analogue with the longest half-life, hαCGRP8-37S19K-C20DA-γGlu, and the shortest half-life, hαCGRP8-37N25K-C20DA-γGlu.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	To test whether this phenomenon held true for SARS-CoV-2 pseudovirus inhibition, we produced a variant of Griffithsin that was incapable of cross-linking viral proteins (GLG-3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11334037	As the first-line TKI, imatinib offers treatment for advanced and metastatic GISTs, adjuvant therapy in high-risk GISTs and neoadjuvant treatment to downsize large tumors prior to resection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352666	Venetoclax was obtained from LC Laboratories (Woburn, MA, USA), and navitoclax was obtained from MedChem Express (Monmouth Junction, NJ, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	Given that S1PR1-3 is ubiquitously expressed in many organs, we investigated the expression of S1PR1-3 in IL-6-induced keratinocytes after FTY720 treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7433824	However, there were some problems in proposing mifepristone as a candidate for GBM treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "were", "some", "problems", "in", ...
PMC11365427	Flow cytometry analysis of cell cycle following VAPB interference. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "analysis", "of", "cell", "cycle", "following", "VAPB", "interference", ".",...
PMC3681794	Simultaneously transfected and plated cells were maintained in normoxia or hypoxia and harvested at 24 hours hypoxia (at time of treatment) or 96 hours hypoxia (at the end of the experiment).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11395280	The animals genotyped were confirmed using tissues collected during the placement of the identification chips.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "animals", "genotyped", "were", "confirmed", "using", ...
PMC9429973	Median FU was 22.8, 32.3 and 18.4 months in the 3 cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "FU", "was", "22.8", ",", "32.3", "and", "18.4", "months", ...
PMC9910796	Coverslips were mounted with ProLong Glass Antifade Mountant (ThermoFisher) on microscope slides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coverslips", "were", "mounted", "with", "ProLong", "Glass", "Antifade"...
PMC11538390	The low-frequency risk allele G (1.2%) of rs570516915 appears to have originated on the more prevalent haplotype tagged by the risk allele A (24.1%) of rs7546104.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910	After incubation, the media was removed, and the chambers were washed twice with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "incubation", ",", "the", "media", "was", ...
PMC11545737	GSDMB is not activated by caspases, but granzyme A released by cytotoxic T lymphocytes and natural killer cells activates it directly .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSDMB", "is"...
PMC9985266	The hydroxyproline (HYP) content was measured using an ELISA kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hydroxyproline", "(", "HYP", ")", "content", "was", "measured", "using", ...
PMC11171319	To assess these new therapeutic strategies, innovative experimental animal models have to be developed such as the generation of glioblastoma in mice engrafted with HCMV-infected astrocytes and the development of triple-negative breast tumors in NOD/SCID Gamma (NSG) mice engrafted with HCMV-infected mammary epithelial ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among these 17 patients, overall response rate (ORR) was 76% and the complete response rate (CR) was 52%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6627640	Furthermore, there are patients who initially respond to therapy but undergo late relapse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "there", "are", "patients", "who", "initially", ...
PMC11737091	Patients with higher DBF4 expression were diagnosed at later clinical stages and had a worse prognosis and shorter survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "with", "higher", "DBF...
PMC9429973	From January 2022, EPICOVIDEHA will broaden its target population, in order to include children too, establishing the EPICOVIDEHA Kids registry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", ...
PMC6160470	Moreover, in addition to interacting with substrate binding site, verapamil was shown to compete with the catalytic domain of the P-gp ATPase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11711345	HCCLs with the three highest Pa of toxicity (A2780cisR, GIST430, and GIST48, Figure 3) were not associated selectively with any interactions of Pa ≥ 0.7, possibly due to the contribution of interactions with other targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	However, when combined with an PEF, the overall toxicity of the treatment increases significantly, and this increase is highly dependent on the buffer composition (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11319300	Sequences in this region were realigned using the Clustal Omega alignment tool with default parameters (Sievers and Higgins, 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequences", ...
PMC11765988	The proposal mentioned above is complicated by the fact that immune checkpoint inhibitor (ICI) treatment, which includes PD-1, PDL-1, and CTLA-4 inhibitors [], is also known to cause sarcoid-like granulomas through the induced predominance of Th1 response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411004	Sodium butyrate (NaBu) and valproic acid (VPA) have been utilized in the culture of recombinant CHO (rCHO) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], ...
PMC11718031	Also, all four basal media supplemented with IS CHO-CD F12.7 as the feed showed an increase in galactosylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "all", "four", ...
PMC10965315	Using a Zeiss Axiovert 200 microscope, wound closure was observed and captured at 2 and 48 h (Zeiss, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using",...
PMC11471176	Computational investigations conducted in silico have unveiled that carnosine exhibits inhibitory interactions at the ACE2 active site and three additional pockets situated at the interface of ACE2 and the spike protein during the host cell uptake of SARS-CoV-2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11322866	Representative photographs are shown.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "photographs", "are", "shown", "." ] } ]
PMC11422497	shRNA: short hairpin RNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "shRNA", ":", "short", "hairpin", "RNA", "." ] } ]
PMC11190238	Additionally, the loop extrusion model was also shown by cohesin depletion by Schwarzer et al. in a mouse model and through real-time imaging the formation DNA loops by Saccharomyces cerevisiae condensin complex further validated the model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705862	The LRT assumes a Chi-square distribution, and that the restricted (residual) maximum likelihood (REML) is set to false.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	Median time from 1L initiation to 2L initiation was 4.4 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "time", "from", "1L", "initiation", "to", "2L", "initiation", "was", "4.4", ...

PMC11727000

The resulting construct, as well as a control expressing the BioiD ligase alone, was cloned into the pTSIN lentivirus expression vector, and SH-SY5Y neuroblastoma were transduced to produce polyclonal stable pools.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...

PMC9727330

Cytotoxic concentration 50% (CC50) The Asp and NNDAsp were tested for their anticancer properties and calculated the potential CC50 in Caco-2 and NCM-460 cells.

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PMC11248911

The promising derivative arrested cell growth at the G1 phase inducing early and late apoptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "promising", "derivative", "arrested", "cell", "growth", ...

PMC11411131

Ornithine decarboxylase (odc), a target for proteasome degradation, was expected to suppress luciferase activity under full-length protein expression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ornithine", ...

PMC11751675

Based on these findings, the authors proposed that sesquiterpene lactones (SLTs) with structural similarities to brevilin A hold promise as potential anti-influenza agents.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11746942

To explore the consequences of S1P in psoriasis pathogenesis and the potential therapeutic relevance of modulating S1P receptors, we utilized FTY720, a pan-S1PR modulator approved for the treatment of multiple sclerosis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8875242

Hanks’ balanced salt solution, William’s medium E containing L-glutamine (WME), and the bicinchoninic acid protein assay kit were obtained from Thermo Fisher Scientific (Waltham, MA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11506670

It acts as a molecular switch that cycles between an active, GTP (guanosine triphosphate)-bound state, and an inactive, GDP (guanosine diphosphate)-bound state.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Antiepileptic, antihypertensive, and supportive therapy were initiated just after PRES.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antiepileptic", ",", "antihypertensive", ",", "and", "supportive", "therapy", "were", ...

PMC11732628

The cells were incubated in Dulbecco’s Modified Eagle Medium (DMEM; Gibco; Thermo Fisher Scientific, Inc., Shanghai, China) supplemented with 10% fetal bovine serum (FBS; Gibco; Thermo Fisher Scientific, Inc.) at 37 ℃ in a humidified atmosphere containing 5% CO2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9341513

The next largest change is for LTO1 which shows an ∼9.8-fold increase.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "next", "largest", "change", "is", "for", "LTO1", "which", "shows", ...

PMC11706491

Boxplots (B) represent quartile distribution with outliers depicted as dots and table (D) shows mean ± standard deviation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Boxplots", "...

PMC9454852

BOLD-100 causes an increase of ROS as a consequence of the induction of ERO1α overexpression; The rise in ROS and ERO1α levels destabilize ER calcium regulation, leading to a massive release into the cytosol either through TLC and IP3R leakage, but also a Ca overload into the mitochondria by way of MAM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11277157

We have not challenged the cells with an oxidative stimulus , and, as anticipated, no sign of cytotoxicity following siRNAs was observed, which argues for uninterrupted mitochondrial homeostasis.

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PMC11765678

MD simulations could also provide insights into the stability of Erastin’s binding under physiological conditions, revealing conformational changes in P-gp and BCRP upon ligand binding.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3164356

Receptors for other viruses like HIV and hepatitis B virus (HBV) are either missing in the CHO-K1 genome or lacking expression in the transcriptome.

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PMC9429973

In control group early RR was higher if pts had DEL (57.1%(12/21) DEL+ vs 16.1%(5/31) DEL-, p=0.003) or EA (75%(3/4) EA+ vs 24.2%(16/66) EA-, p=0.041).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11756514

Although WTA is a highly abundant glycopolymer on the surface of S. aureus, a range of different surface molecules could be candidates for this additional ligand.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11666785

In the first experiment, Dendra2-Actin plasmid DNA was used to transfect NIH3T3 cells.

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PMC4659567

for RuCl2C17H18N2BrI: C, 32.46; H, 2.88; N, 4.45; found: C, 32.24; H, 2.77; N, 4.22%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11676670

At the same time, we noticed the upregulation of SNAIL, one of the major transcription factors related to epithelial–mesenchymal transition (EMT), which may suggest that this cell line is in a transitional state and could be prone to partial EMT changes under specific conditions, thus expressing an increase in cellular...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11709639

Observing reduced MCUB expression in AD, we used 5xFAD mutant mice with neuronal‐specific MCUB overexpression to assess age‐associated changes in cognitive function, neuropathology, and mitochondrial bioenergetics.

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PMC11194678

RNA was stained with SYTO 12 Green-Fluorescent Nucleic Acid Stain.

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PMC9429973

This real-world study suggests that there is an unmet need in addressing anemia burden with ESAs, and novel and effective treatments are needed.

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PMC11544771

In line with this, the combined treatment induced more apoptosis than either single treatment.

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PMC9966931

The indicator of cytotoxicity (potential anticancer effects) is an LC50 value less than 1000 µg/mL. The EO-based hybrid molecules developed here exhibited a strong correlation between their toxicity against A. salina and their structural features.

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PMC11560255

However, further in vitro and in vivo research is required to improve the findings of this study.

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PMC10818062

These observations indicate a new mode of inter-relationship where the metabolic states of two different lipids are reciprocally influenced via their lipid countertransport.

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PMC11789597

mRNA expression of SLC1A5 and SLC7A5 in MM1S cells expressing shNC or shCAV1 was determined using qRT‐PCR.

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PMC11591794

Accordingly, 1% mercaptoethanol was added to the lysis solution included in the kit, the medium was removed, and 1 mL of this solution was placed in each 25-mL flask washed with D-PBS.

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PMC11680982

Fig. 6Neratinib enhances the efficacy of CDK4/6 inhibitor combined with endocrine therapy by reducing HER2 mRNA stability through the interaction of HER2’s 3’-UTR region with hsa-miR-23a-5p. (

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PMC11361748

Volcano plots highlighting genes that are up- or down-regulated by 8-fold or more (adj.

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PMC9429973

In the overall population (2011-2021), the majority of patients had received 1L treatment with bendamustine-rituximab (BR, 53.9%), rituximab plus other regimens (27.6%), or rituximab monotherapy (11.2%).

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PMC11657695

With the exception of KCNA5 (Figure S1D), the expression of the other Kv1-encoding genes is not significantly correlated with survival in ES patients (Figures S1A-S1G, lower panels).Fig.

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PMC11085211

Another study demonstrated that the pyrogallol moiety in polyphenols had an important role to play in apoptosis induction in human embryonic kidney cells (HEK293T) and the chronic myelogenous leukemia cell line (K562), even though the mechanism was not investigated .

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PMC9429973

To test this, we measured the effects of LF/IFPRLR knockdown on B cells in vivo in transgenic mouse models of SLE (Stage 1/ Aim 1), DLBCL (Stage 2/ Aim 2), and in vitro in malignant human B cells (Stage 3/ Aim 3).

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PMC10887351

There have been difficulties with the development of clinical studies due to the poor pharmacological profile of β3-AR blockers and the limitation on the understanding of β3-AR functions.

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PMC9429973

In VIALE-A, median duration of response (mDOR) for CR/CRi (95% CI) was not reached (NR; 17.5−NR) and was 12.9 mo (7.9−17.3) in the Ven+Aza+G-CSF and Ven+Aza+non-G-CSF groups, respectively (Table); DOR at 12 mo was 67% and 53%.

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PMC11670954

However, the mechanisms by which BA protects the intestinal mucosal barrier remain to be elucidated.

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PMC11423992

TFAB002s bind to both CD20-expressing tumor cells and CD3ε-expressing T cells, causing crosslinking between T cells and tumor cells, which leads to T-cell activation, tumor cell lysis, and subsequent secretion of cytokines.

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PMC10847511

Secondly, the in vitro drug screening assays examined in the cell line databases evaluated drug response over a very short period of 3–5 days, which is considerably shorter than the assessment of efficacy in vivo or in clinical tumors, where it is usually assessed on a weekly or monthly basis.

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PMC9429973

71 IgD MM patients received induction therapy based on ‘novel therapies’, 26 on ‘traditional therapies’.

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PMC11766309

Furthermore, in terms of OS, there was a negative correlation between a high expression of YKT6 and a longer life expectancy, and a K‒M plot was used to further analyze the correlation between YKT6 expression and prognosis in various cancers, including ACC, BLCA, CESC, HNSC, LGG, LIHC, LUAD, MESO, and UVM (Figure 4B–J)...

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PMC9429973

We hypothesized that spectral Flow-MRD allows for monitoring leukemic disease burden with unprecedented resolution.

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PMC10440586

Since TAMs produce low levels of pro-inflammatory cytokines and lack T-cell co-stimulation factors, causing T-cell exclusion which facilitates tumor escape from immunosurveillance .

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PMC10218459

Exposure to CPP for 20 s led to a complete inhibition of cell growth (Figure 3).

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PMC11764090

The influence of cold stress depends on the status of plant cellular morphology (e.g., membranes and organelles) , biochemistry (e.g., enzyme activity) , physiological functioning (e.g., gas exchange and water management) , and phenology (e.g., developmental stages) .

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PMC11367146

The MD simulation was performed for high ranked docked complex, i.e. for three selected apoproteins (BCL2, ESR1 and MMP9) and their interaction with two lead compounds, daucosterol and gigantol, over a duration of 100 ns.

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PMC11412752

The reduced cellular viability observed in HepG2 cells following STING deletion aligns with recent research, which suggests that the cGAS-STING pathway drives the survival of chromosomally instable cancers .

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PMC11461874

The mRNA levels of DBP normalized by ACTB are shown.

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PMC9429973

A transcriptional signature was associated with more durable ide-cel responses, which we postulate may outline a distinct suboptimal pretreatment feature in an ide-cel context; further exploration of this preliminary signal is ongoing. **

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PMC6617630

Bar represents mean ± SD from three separate experiments.

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PMC8753818

In this assay each experiment was repeated 3 times and n = 3, (*: > 0.05, **: > 0.01, ***: > 0.001, ****: > 0.0001)Fig.

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PMC11787355

IPTOs from three HLA-A*02 patients were treated with TCR-T and interrogated by scRNA-seq.

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PMC11295144

Fluorescent imaging was done using Zeiss 700 confocal microscope at 63 × magnification with image size 1,024 × 1,024.

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PMC10669128

Nonetheless, not all the therapeutic approaches can be tested in vitro.

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PMC9429973

Comparison of physician characteristics between the HMA non-prescribing vs HMA prescribing groups did not show significant differences in terms of age (54.5 vs 52.2 years; p=0.13), sex (69.7 vs 75.6% male; p=0.34), specialty (hematologist/oncologist, 90.5 vs 86.8; p=0.58), years since graduation (28.2 vs 25.4 years; p=...

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PMC11742290

In the presence of R-spondin (RSPO), LGR5 binds to RSPO, RNF43/ZNRF3 is neutralized, and intracellular β-catenin is accumulated and increased, leading to enhanced activation of the WNT signaling pathway.

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PMC11568601

CHOP antibody (No. 15204-1-AP) was acquired from Proteintech Group, Inc. (Wuhan, China).

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PMC11665584

Finally, PITX1 enhanced full-thickness cutaneous wound healing by promoting keratinocyte migration and stimulating a neutrophil-spearheaded immune response into the wound bed.

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PMC11476004

Some tumours are more common in large breeds of dogs: St. Bernard, Doberman, Golden Retriever, Boxer, and German Shepherd .

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PMC11409031

The primary reason for this high fatality rate is the late detection of the majority of cases .

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PMC7987994

However, for degradable materials, these ratios are inappropriate.

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PMC10092581

In addition, TEM analyses were performed on H157 cells after 24 h treatment with IC50 concentrations of the representative complexes [AuCl] and [AgCl] as well as of auranofin.

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PMC10988808

F Apoptosis assays and the relative quantitative results.

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PMC11742047

Fig. 2Cell apoptosis and necrosis in HL-60 and K-562.

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PMC11730311

Next, we compared metabolites derived from the lipidated hαCGRP8-37 analogue with the longest half-life, hαCGRP8-37S19K-C20DA-γGlu, and the shortest half-life, hαCGRP8-37N25K-C20DA-γGlu.

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PMC10747160

To test whether this phenomenon held true for SARS-CoV-2 pseudovirus inhibition, we produced a variant of Griffithsin that was incapable of cross-linking viral proteins (GLG-3A).

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PMC11334037

As the first-line TKI, imatinib offers treatment for advanced and metastatic GISTs, adjuvant therapy in high-risk GISTs and neoadjuvant treatment to downsize large tumors prior to resection.

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PMC11352666

Venetoclax was obtained from LC Laboratories (Woburn, MA, USA), and navitoclax was obtained from MedChem Express (Monmouth Junction, NJ, USA).

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PMC11746942

Given that S1PR1-3 is ubiquitously expressed in many organs, we investigated the expression of S1PR1-3 in IL-6-induced keratinocytes after FTY720 treatment.

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PMC7433824

However, there were some problems in proposing mifepristone as a candidate for GBM treatment.

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PMC11365427

Flow cytometry analysis of cell cycle following VAPB interference. (

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PMC3681794

Simultaneously transfected and plated cells were maintained in normoxia or hypoxia and harvested at 24 hours hypoxia (at time of treatment) or 96 hours hypoxia (at the end of the experiment).

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PMC11395280

The animals genotyped were confirmed using tissues collected during the placement of the identification chips.

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PMC9429973

Median FU was 22.8, 32.3 and 18.4 months in the 3 cohorts.

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PMC9910796

Coverslips were mounted with ProLong Glass Antifade Mountant (ThermoFisher) on microscope slides.

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PMC11538390

The low-frequency risk allele G (1.2%) of rs570516915 appears to have originated on the more prevalent haplotype tagged by the risk allele A (24.1%) of rs7546104.

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PMC11129910

After incubation, the media was removed, and the chambers were washed twice with PBS.

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PMC11545737

GSDMB is not activated by caspases, but granzyme A released by cytotoxic T lymphocytes and natural killer cells activates it directly .

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PMC9985266

The hydroxyproline (HYP) content was measured using an ELISA kit.

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PMC11171319

To assess these new therapeutic strategies, innovative experimental animal models have to be developed such as the generation of glioblastoma in mice engrafted with HCMV-infected astrocytes and the development of triple-negative breast tumors in NOD/SCID Gamma (NSG) mice engrafted with HCMV-infected mammary epithelial ...

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PMC9429973

Among these 17 patients, overall response rate (ORR) was 76% and the complete response rate (CR) was 52%.

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PMC6627640

Furthermore, there are patients who initially respond to therapy but undergo late relapse.

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PMC11737091

Patients with higher DBF4 expression were diagnosed at later clinical stages and had a worse prognosis and shorter survival.

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PMC9429973

From January 2022, EPICOVIDEHA will broaden its target population, in order to include children too, establishing the EPICOVIDEHA Kids registry.

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PMC6160470

Moreover, in addition to interacting with substrate binding site, verapamil was shown to compete with the catalytic domain of the P-gp ATPase.

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PMC11711345

HCCLs with the three highest Pa of toxicity (A2780cisR, GIST430, and GIST48, Figure 3) were not associated selectively with any interactions of Pa ≥ 0.7, possibly due to the contribution of interactions with other targets.

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PMC11266100

However, when combined with an PEF, the overall toxicity of the treatment increases significantly, and this increase is highly dependent on the buffer composition (Figure 3).

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PMC11319300

Sequences in this region were realigned using the Clustal Omega alignment tool with default parameters (Sievers and Higgins, 2021).

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PMC11765988

The proposal mentioned above is complicated by the fact that immune checkpoint inhibitor (ICI) treatment, which includes PD-1, PDL-1, and CTLA-4 inhibitors [], is also known to cause sarcoid-like granulomas through the induced predominance of Th1 response.

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PMC11411004

Sodium butyrate (NaBu) and valproic acid (VPA) have been utilized in the culture of recombinant CHO (rCHO) cells.

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PMC11718031

Also, all four basal media supplemented with IS CHO-CD F12.7 as the feed showed an increase in galactosylation.

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PMC10965315

Using a Zeiss Axiovert 200 microscope, wound closure was observed and captured at 2 and 48 h (Zeiss, Germany).

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PMC11471176

Computational investigations conducted in silico have unveiled that carnosine exhibits inhibitory interactions at the ACE2 active site and three additional pockets situated at the interface of ACE2 and the spike protein during the host cell uptake of SARS-CoV-2 .

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PMC11322866

Representative photographs are shown.

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PMC11422497

shRNA: short hairpin RNA.

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PMC11190238

Additionally, the loop extrusion model was also shown by cohesin depletion by Schwarzer et al. in a mouse model and through real-time imaging the formation DNA loops by Saccharomyces cerevisiae condensin complex further validated the model.

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PMC11705862

The LRT assumes a Chi-square distribution, and that the restricted (residual) maximum likelihood (REML) is set to false.

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PMC9429973

Median time from 1L initiation to 2L initiation was 4.4 years.

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