OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11529598	B. Dual luciferase reporter gene assays were performed on U251 miR-3154 sponge or A172 miR-3154 sponge and their control cells transfected with wild-type or mutant TP53INP1 3’-UTR. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11066331	In eukaryotic cells, the batch effects of MS can decrease the sensitivity of analysis and limit the biotyping-based quality control .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "eukaryotic", ...
PMC3730428	NCI-H28, JU77 and MM98 cells were maintained in RPMI medium (Invitrogen, Paisley, UK) supplemented with 10% fetal bovine serum (Invitrogen).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC5874706	Solvent and a part of water were evaporated under reduced pressure, and the total volume was adjusted to 20 mL with deionized water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11267830	This evidence supports the hypothesis that THOC1 acts as a critical downstream target in the mechanism of action of indisulam in T-ALL.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "evid...
PMC11599565	Another hypothetical possibility is via viral infection, where HERV envelope proteins with fusogenic potential are transactivated by a neurotropic virus and their possible helpers (given the neuronal background of ovarian carcinoma cells) or epigenetic stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10998613	Individual curves were then averaged and fitted to a two-dimensional diffusion model with triplet-blinking using a nonlinear least squares model as shown in Eq. 3.Gτ=G01-F-Fe-τ/-τT1-F11+ττD, where F is the triplet state fraction, is the triple state lag time, is the dwell time, and is the correlation function amplitude...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541241	With the exception of V. dahliae, we find homologues of PDK and PTEN in all the species.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "exception", "of", "V.",...
PMC3931643	Analysis of the cap binding complex with a m-GTP pull down assay showed that in VAL cells with 4EBP1 “add-back”, asTORi treatment increased the amount of 4EBP1 binding to eIF4E and concomitantly decreased the eIF4G association ( Fig. 7 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Data were obtained from patients enrolled with previously untreated DLBCL in the Phase III GOYA study (NCT01287741).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "D...
PMC11566417	c Percentage of colony forming cells in primary and immortalized p10 and p20 MDEC cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Percentage", "of", "colony", "forming", "cells", "in",...
PMC9429973	Figure B displays the median eGFR according to age groups for AML-LTS and DEGS1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "B", "displays", "the", "median", "eGFR", "according", ...
PMC11128598	The underlying cause of this variability is challenging to identify, given the compound’s pleiotropic effects, which may vary depending on genetic backgrounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC4112127	The medium was then removed, and 150 μl DMSO (Sigma Aldrich) was added to solubilize the MTT formazan.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "medium", "...
PMC11209164	These findings collectively indicate that TPF selectively enhances the infectivity of VSVΔ51 but with some variation across human and murine tumor explants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "fin...
PMC11697065	No. 780271) using a Hamilton-star liquid handler (Hamilton, Reno, NV, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "780271", ")", "using", "a", "Hamilto...
PMC11476264	There is a strong association between FBXO11 and ZEB1 in non-small cell lung cancer (NSLC) in a clinical database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "a"...
PMC8759873	This indicates that the cell value of 786-0 cells transfected with the VHL gene is significantly reduced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicates"...
PMC7334607	This value in the heatmap is denoted as gray, but Figure S1 remains uncensored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "value", "in", "the", "heatmap", "is", "denoted", ...
PMC8735881	In the present study, the successful design of the CMI constructs by genetically linking 10E8 scFv and fusion-inhibitory peptide P41 did offer GPI-anchored bifunctional inhibitors with multiple advantages, including its inhibitory potency and breadth as well as potential genetic resistance barrier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257203	P < 0.01 and ***P < 0.001 indicate significant differences compared to the control group; P < 0.05 between the designated groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Out of these 15 pts, 4 had previous episodes of anaphylaxis, and 5 (3ASM, 2 SM-AHN) were in treatment with KI (2 Imatinib, 3 Midostaurin).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Blood was taken of patients and controls in parallel and peripheral blood mononuclear cells (PBMCs) were isolated using a density gradient centrifugation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10196713	The following target sequences were used: siFdx1#1, 5′-CGAUCUGGCAUAUGGACUA-3′ and 5′-UAGUCCAUAUGCCAGAUCG-3′; and siFdx1#2, 5′-GCCAAAUCUGUUUGACAAA-3′ and 5′-UUUGUCAAACAGAUUUGGC-3′. Cell viability was assessed by the WST8 assay using Cell Counting Kit 8 (CCK-8; Dojindo Laboratories, Inc.) according to the manufacturer's ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	Therefore, in 2020, Zhang et al. found that after overexpression of FGF18, FGFR2 expression could be enhanced, and then the expression of F-actin and YAP1 target was also enhanced, and nuclear accumulation of YAP1 occurred.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7612475	MDS generally occurs in older patients (>60 years old), whom are often not deemed fit for treatment with DNA-damaging therapies such as etoposide, which can be relatively toxic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11610461	γ-secretase can cleave proteins in transmembrane domains (Klein et al., 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "γ-secretase", "can", "cleave", "proteins", "in", "transmembrane", "dom...
PMC6461034	Taken together, combination of the four INKA components into a single score averages out noise and results in a more robust kinase activity ranking than each individual component by itself, and can also be applied in a differential setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11026382	For example, inhibiting TYMS activity in the clinic may promote the evolution of drug resistance in DHFR, while activating TYMS may restrict evolutionary accessible paths.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9509578	The tumor microenvironment is also responsible for creating the hypoxic conditions that lead to MDR, as oxygen-deprived cells grow slowly and are less susceptible to conventional chemotherapeutic drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	More sophisticated methods such as SDS- and native PAGE or ectacytometry can elucidate unclear cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "sophisticated", "methods", "such", "as", "SDS-", "a...
PMC11794568	Next, we applied rotenone at concentrations of 8µM and 9µM to culture CRIP1-silenced SK-MEL-2 and A375 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "Next", ",", "we", "applied...
PMC11674834	In CHO cells expressing CYP1A2 and NAT1, 3,4-DMA caused concentration-dependent increases in reactive oxygen species (ROS), double-stranded DNA damage, and HPRT mutations.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705862	Furthermore, an increasing number of studies suggest that also the complement system is implicated in AD .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "an", "increasing", "number", ...
PMC4659567	Again, the Ru–SG adduct does not contain neither 3Claza nor p-cymene ligands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Again", ",", "the", "Ru", "–", "SG", "adduct", "does"...
PMC9219615	Afterward, samples were triple-stained with 50 μL of 0.1% v/v Tween 20 in 1× PBS solution containing 5 μg/mL DAPI to visualize nuclei, 0.165 μM Alexa Fluor 568-conjugated phalloidin for actin microfilaments (F-actin), and 0.5 μg/mL Alexa Fluor 488-conjugated anti-α-tubulin monoclonal antibody for microtubules (polymeri...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11277157	We show that siRNA causes a stress response that is converted to an antiviral cascade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "show", "that", "siRNA", "causes", "a", "stress", ...
PMC10419319	The bubble chart and bar graph were plotted using an online platform (https://www.bioinformatics.com.cn/, accessed on 2 June 2023) for visualization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11519583	The proportion of EdU-positive (left) or Ki-67-positive (right) cells was quantified (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "proportion", "of", ...
PMC10568263	In addition, this study chose a lung adenocarcinoma cell line as a model and employed Paclitaxel to induce cell death, observing changes in the concentration of the apoptosis-related protein HSP70.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502066	G protein-coupled receptors (GPCRs) comprise the largest and most diverse family of cell surface receptors in eukaryotes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "protein-coupled", "receptors", ...
PMC11461833	Venn diagram showing the overlap between the upregulated and downregulated genes in early hHEPs and WM 3835-treated late hHEPs compared with late hHEPs, as determined by RNA-seq analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	Then PCR was performed with Phusion High-Fidelity DNA polymerase, Universal PCR primers, and Index Primer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "PCR", "was", "performed", "with", "...
PMC11194678	STHdh and STHdh cells were gifts from Boxun Lu (Li et al., 2015; Yu et al., 2017).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11683240	Therefore, Chinese hamster ovary cells strain K1 (CHO-K1) cells were incubated with PT and the respective library fractions on cells for 4 h. Cell lysates were generated and incubated with recombinant PTS1 and biotin-labeled cosubstrate NAD.	[ { "tags": [ "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Chimerism was calculated based on the percentage of unique donor and recipient markers in informative STR loci using GeneMapper v.4-0 software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chimeri...
PMC10142392	A study conducted by Zhu et al. in 2016 achieved the synthesis and characterization of an amphiphilic copolymer A(AB)3 polymer (where A = PCL2800 and B = PEG), which utilized an oligosaccharide as a branching core combined with PEG and PCL .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	Contour plots as in ‘A’ using parental cells and a single FURIN∆ clone (#2.2.G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Contour", "plots", "as", "in", ...
PMC11678368	The complexes trans-[PdCl2(4ClL)2] and trans-[MCl2(5ClL)2] (M = Pd(II), Pt(II)) were synthesized following a modified procedure for the synthesis of trans-[PtCl2(7AI3CA)2] and trans-[PdCl2(7AI3CA)2] as described in references .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739670	There are CD8 lymphocyte populations able to respond to nonpeptide antigens such as lipids presented on CD1a, b, c, and d, and bacterial riboflavin metabolites presented on MR1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757230	Conversely, many studies have shown that human MSCs inhibit the development of malignancies such as Kaposi's sarcoma by increasing inflammatory infiltration, inhibiting tumor angiogenesis, suppressing Wnt and Akt signaling, modulating the cell cycle, and inducing apoptosis of tumor cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574271	Bladder cancer cells were cultured to reach ~95% confluence, followed by creating a linear wound across the diameter of the well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bladder...
PMC5811757	Two-way ANOVA was also used to determine the differences of MTT assay between the groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "ANOVA", "was", "also", "used", "to", "determine"...
PMC11627398	Consequently, investigating the roles of these genes in septic shock could enhance our understanding of its pathogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "investigating", "the", ...
PMC7961460	Changes in matrix deposition and alterations of genes involved in ECM synthesis, including the ones involved in HA metabolism, are key features in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	For both IgG GMCs (Table 1) and OPA GMTs, V114 was generally comparable to PCV13 for the 13 shared serotypes, and higher for serotypes 22F and 33F at Day 90.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10553757	This demonstrated that the major mammary cell biological processes induced by GH involve the mitochondria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "demonstrated", "that", "the", "major", "mammary", "...
PMC11472639	Physiological responses to exercise were analysed via one-way repeated measures ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Physiological", "responses", "to", "exercise", "were", "analysed", "via", "one-way", "repea...
PMC9368503	Key to the identification of novel agents is the availability of well-characterised preclinical cell line models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Key", "to", "the", "identification", "of", "novel", ...
PMC6835428	This was paralleled by a significant reduction in the mRNA and protein levels of both MDR1 and BCL2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "paralleled", "by", "a",...
PMC11697703	All confocal images were Deconvolved using a Richardson-Lucy algorithm within 30 iterations using NIS Elements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "confocal", "images", "were", "Deconvolved", "using", ...
PMC11621493	CER, ceramide; CL, cardiolipin; LNAPE, lyso-N-acyl-PE; HexCER, hexosylceramide; PE, phosphatidylethanolamine; PLA2G4, phospholipase A2 group IV; PPE, plasmalogen-PE; SM, sphingomyelin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790971	A lab-built multimodal nonlinear optical microscope was used to image cells in passage 0, passage 1, and passage 2 (Fig. 1b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11759751	P < 0.05; P < 0.01; *P < 0.001 Chidamide bridging intervention promotes the antitumor effect of CD19 CAR T cells in B-NHL subcutaneously transplanted tumor mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973725	Furthermore, IHC analysis revealed that ZNF677 protein levels were downregulated in cancer tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "IHC", "analysis", "revealed", "that", "ZNF677", ...
PMC9429973	To this end, bexmarilimab, an anti-Clever-1 antibody, aims to harness the therapeutic potential of macrophages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "this", "end", ",", "bexmarilimab...
PMC7823217	Viscosity of bioinks is a critical factor that determine the printability and quality of printed tumor constructs, which is related to the chemical components and concentration of biopolymer used in bioinks .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10631132	Staining was performed according to manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Staining", "was", "performed", "according", "to", "manufacturer", "’s", "instructions", "." ] } ]
PMC9341513	Simulated 4C are shown for simulations using U266 chromatin states both with and without the insert. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Simulated", "4C", "are", "shown", "for", "s...
PMC11533140	Table 2 shows the activity of compounds 17e, 17m, 17o, and 17p; all were better than others, suggesting their good affinities with PI3K and verifying the design concept.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629143	Samples were discarded and plates were washed (PBS, 0.05% Tween20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "were", "discarded", "and", "plates", "were", "washed", ...
PMC11190538	The size of the initial phytosomes was reduced using a combination of homogenization (Sonic Vibra cell, Newton, CT, USA) at 20,000 rpm for 20 min, followed by ultrasonication for 15 min at 160 W power, 40 kHz frequency, and 50 percent pulse (Newtown, CT, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680049	The initiated callus showed weak growth intensity and viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "initiated", "callus", "showed", "weak", "growth", "intensity", "and", "viability", "." ] } ]
PMC9429973	Primary endpoint is the obtainment of neutrophils (>500) and the platelet engraftment (>20.000) with no transfusion-dependence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "e...
PMC11727145	For this model, keratinocytes are seeded on DED and overlaid on a grid in contact with both air and liquid medium, leaving the upper layer exposed only to air.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720107	The lysates were then incubated with the caspase-3 substrate Ac-DEVD-pNA in the same buffer at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lysates", "were", "then", "incu...
PMC9268620	The primary forms of cancer mortality are lung cancer, followed by colorectal and liver cancers, accounting for 18.0%, 9.4%, and 8.3% of all cancer deaths, respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592008	Semi-quantification was performed using ImageJ, 1.54j.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Semi-quantification", "was", "performed", "using", "ImageJ", ",", "1.54j", "." ] } ]
PMC11791264	Accordingly, several essential proteins involved in tumor progression were also discovered to be non-histone substrates of SETD7, including the tumor suppressor p53 (10, 11), nuclear factor kB (NF-kB) p65 (12), hypoxia-induced factor-1a (HIF-1a) (13), β-catenin (14), and the proto-oncogene KRAS (15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257203	Free radicals become neutral and inactive by receiving a proton from curcumin or by taking an electron (11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Free", "radicals", "become",...
PMC11742670	In modern drug discovery, especially in virtual screening (VS) as a main tool of drug repositioning (repurposing), finding screening hits, and optimizing those hits to improve oral bioavailability, metabolic stability, efficacy/potency, affinity, and selectivity will utilize the features of lead drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9856122	BBR interferes with certain pathways such as nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase/extracellular-signal-regulated kinase (MEK/ERK), and mammalian target of rapamycin and the adenosine monophosphate-activated protein kinase (AMPK/mTOR) to resist viral replication, thereby, providing antiviral ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11285179	They regulate endothelial cells' survival, proliferation, and migration by interacting with Tie receptors, thus vital to vascular normalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "regu...
PMC11748335	However, specific features and functions of S/I/L-PMDs remain unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "specific", "features", "and", "functions", "of", "S/I/L-PMDs", "remain", "unclea...
PMC11754784	Flow cytometry results (Fig. 2d and Supplementary Fig. 10) shows that target CEM cells exhibited obvious fluorescent intensity in both TAMRA (red) and FAM (green) channels after incubating with DNP1 and showed negligible fluorescence in both channels after incubating with cage-Nb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9681981	To reduce errors, the experiments were conducted in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "reduce", "errors", ",", "the", "experiments", "were", "conducted", "in", "triplicate", ...
PMC11629192	Ofatumumab (OFA) is an anti-CD20 antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ofatumumab", "(", "OFA", ")", "is", "an", "anti-CD20", "antibody", "." ] } ]
PMC11001582	We conducted in vivo two-photon calcium imaging of neurons in superficial and deep layers of the motor cortex of (GR)400 and (PR)400 mice as well as wild-type (WT) controls using the red-shifted genetically encoded calcium indicator jRCaMP1b at 18 months of age (Fig. 3c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10759659	Furthermore, our study suggests that ARID1A deficiency might be a promising predictive biomarker for assessing the therapeutic outcomes of ICBs in HBV-HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further...
PMC11461025	Biflavanoids are dimers of flavonoid subunits and have also been reported to have numerous beneficial properties including anti-cancer, anti-bacterial, antioxidant, and anti-inflammatory (Gontijo et al. 2017; Samec et al. 2022) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4659567	With respect to instability of the studied complexes in the solvents used, it may be concluded that the anticancer inactivity of the compounds is associated with this property and formation of inactive species (starting ruthenium(II) dimer, released naza, solvolysis products).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10809689	The results of the GC for α-KG in the supernatants of THP-1 cell cultures showed that the concentration of this keto acid decreased after 24 h of treatment with Gal-9 compared to the control (p = 0.0001) and PMA (p = 0.001) groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	Four hours later, cells were infected with VSVΔ51-GFP (MOI 0.1). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "hours", "later", ",", "cells", "were", "infected", "with...
PMC10530622	Oxalate (0.05 mM) exposure in differentiated THP-1 macrophages was also associated with altered cellular bioenergetics, mitochondrial gene expression and complex activity, ATP levels, redox homeostasis, anti-bacterial response and cytokine secretion .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10142392	Colloidal systems based on PCL are of great interest due to their use as drug carriers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colloidal", "systems", "based", "on", "PCL", "are", ...
PMC11763111	CD38 is a promising tumor antigen with significant potential for the treatment of multiple myeloma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD38", "is", "a", "promising", "tumor", "antigen", "with", ...
PMC11604830	T1 and T2 relaxation times were measured at 298 and 310 K, ranging from 0.6 to 0.7 s for T1 and showing faster T2 decays, particularly for PEG‐LIPO, where a bi‐exponential behavior was observed, likely somehow attributable to the presence of two dynamically different environments for the polymer: the one pointing inwar...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10165258	Meanwhile, the secondary part of the anchor ((ii), blue) has a 230 μm width and an 80 μm depth, providing a smaller capillary trapping force.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mutations of SAMHD1 gene have been linked to Aicardi-Goutières syndrome (AGS) and have been detected in a subset of chronic lymphocytic leukemia, mantle cell lymphoma, and T-prolymphocytic leukemias.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803918	To conclude, both in vitro and in vivo experiments verified the active targeting effect of hybrid exosomes in melanoma tissues, possibly attributed to functional surface markers such as CCR5 and PD-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11529598

B. Dual luciferase reporter gene assays were performed on U251 miR-3154 sponge or A172 miR-3154 sponge and their control cells transfected with wild-type or mutant TP53INP1 3’-UTR. *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11066331

In eukaryotic cells, the batch effects of MS can decrease the sensitivity of analysis and limit the biotyping-based quality control .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "eukaryotic", ...

PMC3730428

NCI-H28, JU77 and MM98 cells were maintained in RPMI medium (Invitrogen, Paisley, UK) supplemented with 10% fetal bovine serum (Invitrogen).

[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...

PMC5874706

Solvent and a part of water were evaporated under reduced pressure, and the total volume was adjusted to 20 mL with deionized water.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11267830

This evidence supports the hypothesis that THOC1 acts as a critical downstream target in the mechanism of action of indisulam in T-ALL.Fig.

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PMC11599565

Another hypothetical possibility is via viral infection, where HERV envelope proteins with fusogenic potential are transactivated by a neurotropic virus and their possible helpers (given the neuronal background of ovarian carcinoma cells) or epigenetic stress.

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PMC10998613

Individual curves were then averaged and fitted to a two-dimensional diffusion model with triplet-blinking using a nonlinear least squares model as shown in Eq. 3.Gτ=G01-F-Fe-τ/-τT1-F11+ττD, where F is the triplet state fraction, is the triple state lag time, is the dwell time, and is the correlation function amplitude...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11541241

With the exception of V. dahliae, we find homologues of PDK and PTEN in all the species.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "exception", "of", "V.",...

PMC3931643

Analysis of the cap binding complex with a m-GTP pull down assay showed that in VAL cells with 4EBP1 “add-back”, asTORi treatment increased the amount of 4EBP1 binding to eIF4E and concomitantly decreased the eIF4G association ( Fig. 7 ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: Data were obtained from patients enrolled with previously untreated DLBCL in the Phase III GOYA study (NCT01287741).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "D...

PMC11566417

c Percentage of colony forming cells in primary and immortalized p10 and p20 MDEC cultures.

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PMC9429973

Figure B displays the median eGFR according to age groups for AML-LTS and DEGS1.

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PMC11128598

The underlying cause of this variability is challenging to identify, given the compound’s pleiotropic effects, which may vary depending on genetic backgrounds.

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PMC4112127

The medium was then removed, and 150 μl DMSO (Sigma Aldrich) was added to solubilize the MTT formazan.

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PMC11209164

These findings collectively indicate that TPF selectively enhances the infectivity of VSVΔ51 but with some variation across human and murine tumor explants.

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PMC11697065

No. 780271) using a Hamilton-star liquid handler (Hamilton, Reno, NV, USA).

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PMC11476264

There is a strong association between FBXO11 and ZEB1 in non-small cell lung cancer (NSLC) in a clinical database.

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PMC8759873

This indicates that the cell value of 786-0 cells transfected with the VHL gene is significantly reduced.

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PMC7334607

This value in the heatmap is denoted as gray, but Figure S1 remains uncensored.

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PMC8735881

In the present study, the successful design of the CMI constructs by genetically linking 10E8 scFv and fusion-inhibitory peptide P41 did offer GPI-anchored bifunctional inhibitors with multiple advantages, including its inhibitory potency and breadth as well as potential genetic resistance barrier.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11257203

P < 0.01 and ***P < 0.001 indicate significant differences compared to the control group; P < 0.05 between the designated groups.

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PMC9429973

Out of these 15 pts, 4 had previous episodes of anaphylaxis, and 5 (3ASM, 2 SM-AHN) were in treatment with KI (2 Imatinib, 3 Midostaurin).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Blood was taken of patients and controls in parallel and peripheral blood mononuclear cells (PBMCs) were isolated using a density gradient centrifugation.

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PMC10196713

The following target sequences were used: siFdx1#1, 5′-CGAUCUGGCAUAUGGACUA-3′ and 5′-UAGUCCAUAUGCCAGAUCG-3′; and siFdx1#2, 5′-GCCAAAUCUGUUUGACAAA-3′ and 5′-UUUGUCAAACAGAUUUGGC-3′. Cell viability was assessed by the WST8 assay using Cell Counting Kit 8 (CCK-8; Dojindo Laboratories, Inc.) according to the manufacturer's ...

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PMC10203589

Therefore, in 2020, Zhang et al. found that after overexpression of FGF18, FGFR2 expression could be enhanced, and then the expression of F-actin and YAP1 target was also enhanced, and nuclear accumulation of YAP1 occurred.

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PMC7612475

MDS generally occurs in older patients (>60 years old), whom are often not deemed fit for treatment with DNA-damaging therapies such as etoposide, which can be relatively toxic.

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PMC11610461

γ-secretase can cleave proteins in transmembrane domains (Klein et al., 2022).

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PMC6461034

Taken together, combination of the four INKA components into a single score averages out noise and results in a more robust kinase activity ranking than each individual component by itself, and can also be applied in a differential setting.

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PMC11026382

For example, inhibiting TYMS activity in the clinic may promote the evolution of drug resistance in DHFR, while activating TYMS may restrict evolutionary accessible paths.

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PMC9509578

The tumor microenvironment is also responsible for creating the hypoxic conditions that lead to MDR, as oxygen-deprived cells grow slowly and are less susceptible to conventional chemotherapeutic drugs.

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PMC9429973

More sophisticated methods such as SDS- and native PAGE or ectacytometry can elucidate unclear cases.

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PMC11794568

Next, we applied rotenone at concentrations of 8µM and 9µM to culture CRIP1-silenced SK-MEL-2 and A375 cells.

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PMC11674834

In CHO cells expressing CYP1A2 and NAT1, 3,4-DMA caused concentration-dependent increases in reactive oxygen species (ROS), double-stranded DNA damage, and HPRT mutations.

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PMC11705862

Furthermore, an increasing number of studies suggest that also the complement system is implicated in AD .

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PMC4659567

Again, the Ru–SG adduct does not contain neither 3Claza nor p-cymene ligands.

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PMC9219615

Afterward, samples were triple-stained with 50 μL of 0.1% v/v Tween 20 in 1× PBS solution containing 5 μg/mL DAPI to visualize nuclei, 0.165 μM Alexa Fluor 568-conjugated phalloidin for actin microfilaments (F-actin), and 0.5 μg/mL Alexa Fluor 488-conjugated anti-α-tubulin monoclonal antibody for microtubules (polymeri...

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PMC11277157

We show that siRNA causes a stress response that is converted to an antiviral cascade.

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PMC10419319

The bubble chart and bar graph were plotted using an online platform (https://www.bioinformatics.com.cn/, accessed on 2 June 2023) for visualization.

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PMC11519583

The proportion of EdU-positive (left) or Ki-67-positive (right) cells was quantified (n = 3).

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PMC10568263

In addition, this study chose a lung adenocarcinoma cell line as a model and employed Paclitaxel to induce cell death, observing changes in the concentration of the apoptosis-related protein HSP70.

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PMC11502066

G protein-coupled receptors (GPCRs) comprise the largest and most diverse family of cell surface receptors in eukaryotes .

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PMC11461833

Venn diagram showing the overlap between the upregulated and downregulated genes in early hHEPs and WM 3835-treated late hHEPs compared with late hHEPs, as determined by RNA-seq analysis.

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PMC11770130

Then PCR was performed with Phusion High-Fidelity DNA polymerase, Universal PCR primers, and Index Primer.

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PMC11194678

STHdh and STHdh cells were gifts from Boxun Lu (Li et al., 2015; Yu et al., 2017).

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PMC11683240

Therefore, Chinese hamster ovary cells strain K1 (CHO-K1) cells were incubated with PT and the respective library fractions on cells for 4 h. Cell lysates were generated and incubated with recombinant PTS1 and biotin-labeled cosubstrate NAD.

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PMC9429973

Chimerism was calculated based on the percentage of unique donor and recipient markers in informative STR loci using GeneMapper v.4-0 software.

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PMC10142392

A study conducted by Zhu et al. in 2016 achieved the synthesis and characterization of an amphiphilic copolymer A(AB)3 polymer (where A = PCL2800 and B = PEG), which utilized an oligosaccharide as a branching core combined with PEG and PCL .

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PMC11286266

Contour plots as in ‘A’ using parental cells and a single FURIN∆ clone (#2.2.G).

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PMC11678368

The complexes trans-[PdCl2(4ClL)2] and trans-[MCl2(5ClL)2] (M = Pd(II), Pt(II)) were synthesized following a modified procedure for the synthesis of trans-[PtCl2(7AI3CA)2] and trans-[PdCl2(7AI3CA)2] as described in references .

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PMC11739670

There are CD8 lymphocyte populations able to respond to nonpeptide antigens such as lipids presented on CD1a, b, c, and d, and bacterial riboflavin metabolites presented on MR1 .

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PMC11757230

Conversely, many studies have shown that human MSCs inhibit the development of malignancies such as Kaposi's sarcoma by increasing inflammatory infiltration, inhibiting tumor angiogenesis, suppressing Wnt and Akt signaling, modulating the cell cycle, and inducing apoptosis of tumor cells .

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PMC11574271

Bladder cancer cells were cultured to reach ~95% confluence, followed by creating a linear wound across the diameter of the well.

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PMC5811757

Two-way ANOVA was also used to determine the differences of MTT assay between the groups.

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PMC11627398

Consequently, investigating the roles of these genes in septic shock could enhance our understanding of its pathogenesis.

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PMC7961460

Changes in matrix deposition and alterations of genes involved in ECM synthesis, including the ones involved in HA metabolism, are key features in cancer.

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PMC9429973

For both IgG GMCs (Table 1) and OPA GMTs, V114 was generally comparable to PCV13 for the 13 shared serotypes, and higher for serotypes 22F and 33F at Day 90.

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PMC10553757

This demonstrated that the major mammary cell biological processes induced by GH involve the mitochondria.

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PMC11472639

Physiological responses to exercise were analysed via one-way repeated measures ANOVA.

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PMC9368503

Key to the identification of novel agents is the availability of well-characterised preclinical cell line models.

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PMC6835428

This was paralleled by a significant reduction in the mRNA and protein levels of both MDR1 and BCL2.

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PMC11697703

All confocal images were Deconvolved using a Richardson-Lucy algorithm within 30 iterations using NIS Elements.

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PMC11621493

CER, ceramide; CL, cardiolipin; LNAPE, lyso-N-acyl-PE; HexCER, hexosylceramide; PE, phosphatidylethanolamine; PLA2G4, phospholipase A2 group IV; PPE, plasmalogen-PE; SM, sphingomyelin.

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PMC11790971

A lab-built multimodal nonlinear optical microscope was used to image cells in passage 0, passage 1, and passage 2 (Fig. 1b).

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PMC11759751

P < 0.05; **P < 0.01; ***P < 0.001 Chidamide bridging intervention promotes the antitumor effect of CD19 CAR T cells in B-NHL subcutaneously transplanted tumor mice.

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PMC8973725

Furthermore, IHC analysis revealed that ZNF677 protein levels were downregulated in cancer tissues.

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PMC9429973

To this end, bexmarilimab, an anti-Clever-1 antibody, aims to harness the therapeutic potential of macrophages.

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PMC7823217

Viscosity of bioinks is a critical factor that determine the printability and quality of printed tumor constructs, which is related to the chemical components and concentration of biopolymer used in bioinks .

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PMC10631132

Staining was performed according to manufacturer’s instructions.

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PMC9341513

Simulated 4C are shown for simulations using U266 chromatin states both with and without the insert. (

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PMC11533140

Table 2 shows the activity of compounds 17e, 17m, 17o, and 17p; all were better than others, suggesting their good affinities with PI3K and verifying the design concept.

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PMC11629143

Samples were discarded and plates were washed (PBS, 0.05% Tween20).

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PMC11190538

The size of the initial phytosomes was reduced using a combination of homogenization (Sonic Vibra cell, Newton, CT, USA) at 20,000 rpm for 20 min, followed by ultrasonication for 15 min at 160 W power, 40 kHz frequency, and 50 percent pulse (Newtown, CT, USA).

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PMC11680049

The initiated callus showed weak growth intensity and viability.

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PMC9429973

Primary endpoint is the obtainment of neutrophils (>500) and the platelet engraftment (>20.000) with no transfusion-dependence.

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PMC11727145

For this model, keratinocytes are seeded on DED and overlaid on a grid in contact with both air and liquid medium, leaving the upper layer exposed only to air.

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PMC11720107

The lysates were then incubated with the caspase-3 substrate Ac-DEVD-pNA in the same buffer at 37 °C.

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PMC9268620

The primary forms of cancer mortality are lung cancer, followed by colorectal and liver cancers, accounting for 18.0%, 9.4%, and 8.3% of all cancer deaths, respectively .

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PMC11592008

Semi-quantification was performed using ImageJ, 1.54j.

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PMC11791264

Accordingly, several essential proteins involved in tumor progression were also discovered to be non-histone substrates of SETD7, including the tumor suppressor p53 (10, 11), nuclear factor kB (NF-kB) p65 (12), hypoxia-induced factor-1a (HIF-1a) (13), β-catenin (14), and the proto-oncogene KRAS (15).

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PMC11257203

Free radicals become neutral and inactive by receiving a proton from curcumin or by taking an electron (11).

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PMC11742670

In modern drug discovery, especially in virtual screening (VS) as a main tool of drug repositioning (repurposing), finding screening hits, and optimizing those hits to improve oral bioavailability, metabolic stability, efficacy/potency, affinity, and selectivity will utilize the features of lead drug.

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PMC9856122

BBR interferes with certain pathways such as nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase/extracellular-signal-regulated kinase (MEK/ERK), and mammalian target of rapamycin and the adenosine monophosphate-activated protein kinase (AMPK/mTOR) to resist viral replication, thereby, providing antiviral ...

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PMC11285179

They regulate endothelial cells' survival, proliferation, and migration by interacting with Tie receptors, thus vital to vascular normalization.

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PMC11748335

However, specific features and functions of S/I/L-PMDs remain unclear.

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PMC11754784

Flow cytometry results (Fig. 2d and Supplementary Fig. 10) shows that target CEM cells exhibited obvious fluorescent intensity in both TAMRA (red) and FAM (green) channels after incubating with DNP1 and showed negligible fluorescence in both channels after incubating with cage-Nb.

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PMC9681981

To reduce errors, the experiments were conducted in triplicate.

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PMC11629192

Ofatumumab (OFA) is an anti-CD20 antibody.

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PMC11001582

We conducted in vivo two-photon calcium imaging of neurons in superficial and deep layers of the motor cortex of (GR)400 and (PR)400 mice as well as wild-type (WT) controls using the red-shifted genetically encoded calcium indicator jRCaMP1b at 18 months of age (Fig. 3c).

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PMC10759659

Furthermore, our study suggests that ARID1A deficiency might be a promising predictive biomarker for assessing the therapeutic outcomes of ICBs in HBV-HCC.

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PMC11461025

Biflavanoids are dimers of flavonoid subunits and have also been reported to have numerous beneficial properties including anti-cancer, anti-bacterial, antioxidant, and anti-inflammatory (Gontijo et al. 2017; Samec et al. 2022) .

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PMC4659567

With respect to instability of the studied complexes in the solvents used, it may be concluded that the anticancer inactivity of the compounds is associated with this property and formation of inactive species (starting ruthenium(II) dimer, released naza, solvolysis products).

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PMC10809689

The results of the GC for α-KG in the supernatants of THP-1 cell cultures showed that the concentration of this keto acid decreased after 24 h of treatment with Gal-9 compared to the control (p = 0.0001) and PMA (p = 0.001) groups.

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PMC9065483

Four hours later, cells were infected with VSVΔ51-GFP (MOI 0.1). (

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PMC10530622

Oxalate (0.05 mM) exposure in differentiated THP-1 macrophages was also associated with altered cellular bioenergetics, mitochondrial gene expression and complex activity, ATP levels, redox homeostasis, anti-bacterial response and cytokine secretion .

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PMC10142392

Colloidal systems based on PCL are of great interest due to their use as drug carriers .

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PMC11763111

CD38 is a promising tumor antigen with significant potential for the treatment of multiple myeloma .

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PMC11604830

T1 and T2 relaxation times were measured at 298 and 310 K, ranging from 0.6 to 0.7 s for T1 and showing faster T2 decays, particularly for PEG‐LIPO, where a bi‐exponential behavior was observed, likely somehow attributable to the presence of two dynamically different environments for the polymer: the one pointing inwar...

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PMC10165258

Meanwhile, the secondary part of the anchor ((ii), blue) has a 230 μm width and an 80 μm depth, providing a smaller capillary trapping force.

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PMC9429973

Mutations of SAMHD1 gene have been linked to Aicardi-Goutières syndrome (AGS) and have been detected in a subset of chronic lymphocytic leukemia, mantle cell lymphoma, and T-prolymphocytic leukemias.

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PMC11803918

To conclude, both in vitro and in vivo experiments verified the active targeting effect of hybrid exosomes in melanoma tissues, possibly attributed to functional surface markers such as CCR5 and PD-1.

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