OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11116779	Our investigation unveiled that PS-NPs markedly decreased cell viability in a concentration-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "investigation", "unveiled", "that", "PS-NPs", "markedly", "decreased", ...
PMC10547921	Figure 2Milestones in the development of ADCs payloads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "2Milestones", "in", "the", "development", "of", "ADCs", "payloads", "." ] } ]
PMC9429973	Glofitamab-related AEs leading to discontinuation were uncommon (3 patients, 3%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glofitamab-related", "AEs", "leading", "to", "discontinuation", "were", ...
PMC10094992	Aldehyde dehydrogenase 1A3 (ALDH1A3), one of the three members of the aldehyde dehydrogenase 1A subfamily, has been associated with increased progression and drug resistance in various types of solid tumours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	To fulfill the energy demands of the cell, rapidly proliferating tumor ECs are known to exist in a hyper glycolytic state by overexpressing phosphofructo-2-kinase/fructose 2,6 bis-phosphatase 3, the glycolytic regulatory enzyme (Cantelmo et al. 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Clinical responses were assessed according to modified International Working Group (IWG) 2003 response criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "responses", "were", "assessed", "according", ...
PMC11752767	Other forms of ACT include B cells, NK cells, macrophages, and dendritic cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "forms", "of", "ACT", "include", "B", "c...
PMC9429973	Aims: Macrocytosis is one of the cytological hallmarks of dyserithropoiesis in MDS: an analysis of the erythropoietic response to ESAs therapy in a cohort of anemic non trasfusion-dependent MDS patients, enrolled in a retrospective register, RECAMDS, subgroup of Italian register, was performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	2Talazoparib plus decitabine treatment potentiates cumulative DNA damage in HRR deficient cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2Talazoparib", "plus", "decitabine", "treatment", "potentiates", "cumulative", "DNA", ...
PMC11684297	The MTT assay results (Fig. 3c) and cell counting by live-dead assay (Fig. 3d) also concluded that the as-synthesized ZnO-NFs could not induce any significant cell killing in the PC12 cells compared to the untreated control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	no. 15596026; Invitrogen), penicillin and streptomycin (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "15596026", ";", "Invitrogen", ")", ",", "penicillin", "and", "streptomycin", "...
PMC11310713	Our method suggests that cell-based hormone therapy may mitigate the risk of breast cancer, a major side effect associated with pharmaceutical HRT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", ...
PMC9429973	TPE could be considered as a therapeutic intervention that can reduce thrombotic risk in patients necessitating an urgent non-cardiac surgery in the acute phase of HIT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11680049	From the histochemical studies presented above, it follows that the studied Sequoia plants are characterized by a high ability to form secondary metabolites of various natures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11633763	Significant differences between two groups were determined using the Student's t‐test, while comparisons between more than two groups were performed using single‐factor analysis of variance (ANOVA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6267596	Diffuse large B-cell lymphoma (DLBCL), an aggressive form of B-cell non-Hodgkin lymphoma (B-NHL), is the most common subtype in adults (∼30%) with ∼45,000 new cases per year.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700523	Second, the role of IS in other CKD models, such as diabetes and hypertension, also remains to be investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Second", ","...
PMC11252033	Regarding acquired resistance, the deregulation of anti-apoptotic genes Bcl-2 and Bcl-xL has been well established (Dai et al., 2023; Karademir and Özgür, 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The serum levels of IL-27 in CLL patients and sick mice were quantified via ELISA and compared to those of healthy controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "serum...
PMC10944868	Understanding the factors that influence drug absorption is essential for optimizing drug therapy and minimizing adverse effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "the", "factors", "that", "influe...
PMC11638764	Dynamic exclusion was set to 30 s. The temperature of ion transfer tube was 300°C and the S-lens RF level was set to 30.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9243326	The trial was performed in accordance with the Institutional Animal Care and Use Committees of Guangxi Academy (CGA-00927).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "trial", "was", ...
PMC11769516	Scientists also analyzed extracts of cow feed, identifying “regulated” and “emerging” mycotoxins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scientists", "also", "analyzed", "extracts", "of"...
PMC8358176	Administration of SWCNTs-COOH and MWCNTs-COOH could result in the up-regulation of TNF and TNFRSF10A but did not initiate apoptosis in Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Administr...
PMC10976516	Costimulatory molecules, including CD40 and CD80, are present in professional APCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Costimulatory", "molecules", ",", "including", "CD40", "and", "CD80", ",", ...
PMC10713411	Kidney renal clear cell carcinoma (KIRC), the most prevalent type of RCC, accounts for approximately 80% of all RCC cases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	In 2018 the International T-cell non-Hodgkin’s Lymphoma Study Group launched the T-cell Project 2.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "2018", "the", "International", "T-cell", "non-Hodgkin", ...
PMC9429973	Overall, 370 genes were differentially expressed (p<0.05) in NR, as compared to R patients, of which 32 were significantly differentially expressed (corrected p < 0.05, FC ≥2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	To analyze memory T cells, the single cell suspensions harvested from spleens were respectively stained with PE-anti-CD8, FITC-anti-CD44 and APC-anti-CD62L antibodies to differentiate central memory T cells (TCM, CD8CD44CD62L) and effector memory T cells (TEM, CD8CD44CD62L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772449	After the cell growth was stable, the experimental treatment was performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the", "cell", "growth", "was", "stable", ",", "the", "experimental", ...
PMC9848491	In addition to immunotherapy, we also analyzed the association between the predictive signature and the efficacy of general chemotherapy for UCEC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC11775197	The function of PPARβ/δ in the context of cancer remains a topic of contention within the scientific community.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "function", "of", "PPARβ/δ", "in...
PMC3734024	These complete data and a full description of the methods used to obtain the cell populations compared are freely available from the NCBI GEO depository (Accession number GSE46245).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6182045	The production of TZ97008 rgp120 in the MGAT1 CHO line provided almost four-fold improvement in Kd of PGT128 binding, six-fold improvement in Kd of PG9 binding, and over ten-fold improvement in Kd of VRC01 binding (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	L. Hebert, P. Shah, O. Diaz, A. A. Street, J. Li, E. Rudenko, A. M. Zlotnicki, C. Morrison, R. Bomben, Y. Huang, A. Medina Herrera, A. Wong, S. Gleen R&D; BioInformatics, Invivoscribe, San Diego; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, United States of America; Clinical and Experimenta...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741906	HR values greater than 1 indicate poor outcome and hazard increase while HR values below 1 indicate good outcome and hazard reduction, whereas HR values equal to 1 indicate no differences in hazard between groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11244823	Each potential control serum was tested against each of the available antigens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "potential", "control", "serum", "was", "tested", "against", "each", "of"...
PMC9429973	The majority had moderate or severe lung tissue damage (CT2 in 44 (33%), CT3 in 25 (20%), CT4 in 13 (10%)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	L. I. Gordon, D. Hoda, L. Shi, S. Guo, F. F. Liu, J. Braverman, R. Dubowy, L. Peng, A. Sehgal Northwestern University, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago; Intermountain Healthcare, Loveland Clinic for Blood Cancer Therapy, Salt Lake City; Evidera, Waltham; Bristol Myers Sq...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8632470	The WST-8 assay showed that the cytotoxicity IC50 of ASE = 2322 μg/mL and IC50 of ALE = 2283 μg/mL. The nephroprotective activity assay revealed that ASE possesses nephroprotective activity against the NAPQI-induced HEK293 cell line at 1161 μg/mL, while ALE does not show the nephroprotective activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8984067	The photosensitizer chlorin e6 (Ce6) and anti-EpCAM were further assembled over UCNP surfaces through the formation of amide linkage, constructing an anti-EpCAM-UCNPs-Ce6 nanoplatform, which was identified through X-ray diffraction (XRD), transmission electron microscopy (TEM), infrared spectrum (IR), and UV-Vis spectr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	K562 cells (4 × 10) were seeded in 6-well plates.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "K562", "cells", "(", "4", "×", "10", ")", "were", "seeded", "in",...
PMC9429973	Median GAD-7 score of all subjects was 5 (range 0-21), with 81 (49.7%), 44 (27%), 31 (19%) and 7 (4.3%) of subjects having no, mild, moderate and severe anxiety symptoms, respectively (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11395280	A significant complication of pediatric T-ALL is CNS invasion where the leukemic cells can hide during standard chemotherapy regimens, resulting in disease recurrence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5963610	Furthermore, a positive clinical outcome is reported for a cancer patient treated with the combination of an anti-EGFR mAb and anti-NGcGM3 therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further...
PMC11746948	The results demonstrated that the APT2 inhibitor ML349 substantially reduced liver injury caused by ischemia-reperfusion, paralleling the effects of Lip-1 (Fig. 8e–g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	There was no significant difference between (GAGSGA)2-8 h and SF in scavenging capacity at 1 mg/mL, although the scavenging capacity of (GAGSGA)2-8 h was lower than the scavenging capacity of SF at 0.01 mg/mL. We further confirmed by flow cytometry that both (GAGSGA)2-8 h group and SF group reduced ROS levels at the ce...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8662250	In addition to these previous publications, our study first demonstrates, as far we know, new and potential effects of CBD in the intestinal epithelium, potentially able to counteract SARS‐CoV‐2 hyper‐inflammation in the gut.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489175	In this context, a role for DUBs in specific tumor types such as ovarian cancer is clearly emerging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "context", ",", ...
PMC11750696	In the absence of stress, these proteins are maintained in an inactive form by the binding with the chaperone BiP. However, upon unfolded protein accumulates within the ER, it promotes the release of BiP, thereby activating these sentinels and initiating the UPR (7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Based on the growth characteristics, cells were divided into two groups of adherent and suspension cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "the", "growth", "characteristics",...
PMC9599726	Drug concentrations were chosen based on previous studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drug", "concentrations", "were", "chosen", "based", "on", "previous", "studies", "." ] } ]
PMC11467800	Representative examples of fluorescence microscopy images of larval xenografts at 2 dpi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "examples", "of", "fluorescence", "microscopy", "images", "of", "larv...
PMC9429973	A different approach is the use of the antigen binding domain of the antibody in chimeric antigen receptors (CARs) expressed in NK or T cells to induce cellular cytotoxicity against ROR1-expressing cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	To provide a baseline.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "To", "provide", "a", "baseline", "." ] } ]
PMC11687663	Extractive yield was estimated as: % Extractive yield = (weight of dry extract / initial weight of dry sample) × 100 The yield obtained from A. helferiana was 22.81% w/w.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8922418	In the process of gene editing, multi-approaches can be utilized to making cells resistant against HIV-1 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "process", "of", "gene", ...
PMC11679326	An interesting feature of metastatic colorectal cancer cells is the prevalence of α2,6-linked sialic acid residues in N-glycans, while α2,6-linked sialic acid residues mediate integrin-dependent adhesion of hepatocarcinoma cells to fibronectin and also promote adhesion of melanoma cells to extracellular matrix componen...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7709199	The GD cell line is derived from the HEK293S MGAT1 cell line and has been transformed with Golgi-resident EndoT (an endo-β-N-acetylglucosaminidase similar to EndoH).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11564322	Interestingly, the c-SRC inhibitor I used alone increased KI67 mRNA only in HL-60 and MEG-A2 (by 24.95 and 49.54%, respectively, compared to the control).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8584666	Moreover, it has also been reported that GPI-80 is associated with malignant tumors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "it", "has", "also", "been", "reported", "that",...
PMC9429973	EDSS score was 1.5 – 7.5 (average 4.5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EDSS", "score", "was", "1.5", "–", "7.5", "(", "average", "4.5", ")", "." ] } ]
PMC11201245	5.8, Metasystems, Altlusheim, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5.8", ",", "Metasystems", ",", "Altlusheim", ",", "Germany", ")", "." ] } ]
PMC9712534	As for TOP2B, a number of germline missense mutations were identified as causative for human diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "for", "TOP2B", ",", "a", "number", ...
PMC11180402	Transcription factor expression in 5637 cells treated with ISO at indicated times. (	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transcription", "factor", "expression", "in", "5637", "cells", "treated"...
PMC11674834	Differences in ROS levels among the CHO cell lines were slight and non-significant (p > 0.05) but followed the pattern UV5 > UV5/1A2 > UV5/1A2/NAT14 > UV5/1A2/NAT114B (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	The disruption of mitochondrial-nuclear crosstalk highlights significant concerns for cellular health and underscores the need for further investigation into these mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "disruption", ...
PMC9960565	The remaining cisplatin-metallodendrimers were characterized by ESI in the positive mode.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "remaining", "cisplatin-metallodendrimers", "were", "characterized", "by", "ESI", "in", ...
PMC11760643	ATP‐induced responses were calculated by subtracting the corresponding basal response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ATP‐induced", "responses", "were", "calculated", "by", "subtracting", "the", "corresponding", "basal",...
PMC11472639	In the absence of clonal plasma cell mobilisation into blood in response to exercise and given that the bulk of myeloma cells reside in the bone marrow (Kyle et al., 2003), it may be that a preferential redistribution of NK-cells and monocytes to bone after exercise – as is seen with T-cells (Krüger et al., 2008) – is ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	WBC at diagnosis was<4000 in 5 cases, 4000-10000 in 2 cases, between 10000-50000 in 7 cases, and >50000 in 1 case.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718817	The presence of M2 macrophages and MDSCs has been shown to render tumors less susceptible to PD-1 blockade .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "presence", "of", "M2", "macroph...
PMC11078693	All resources reported are US sources.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "resources", "reported", "are", "US", "sources", "." ] } ]
PMC11477621	Then, the mixture was quenched with H2O (15 mL) and extracted with dichloromethane (3 × 10 mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", ...
PMC11411131	Krab-Sec (or Krab-Cys) contained the cytomegalovirus (CMV) or EF1α promoter, while luciferase employed the CMV, SV40, or TK promoter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11367146	After scratching, the well was washed twice with medium to remove the detached cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "scratching", ",", "the", "well", "was", "washed", ...
PMC11591038	In the low-dose simvastatin group, the reduced expression of HIF-1α and BACE1 was observed in the SAD cybrids as compared to the controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9960565	In this sense, dendrimers are at the forefront, as they have shown potential for use as drug delivery systems .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "sen...
PMC11564405	In the arena of statistical examination, we engaged in a comprehensive analysis facilitated by the robust tools of GraphPad Prism 7 and SPSS 22.0 software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11781181	Images were captured with an H-7500 electron microscope (Hitachi, Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "captured", "with", "an", "H-7500", "elect...
PMC9429973	Hemoglobins were analyzed by capillary zone electrophoresis (Sebia Capillarys Flex system) and ion exchange HPLC (BioRad Variant II β-thalassemia Short Program).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	CRS occurred in 92% patients, and neurologic toxicities occurred in 87% patients in ZUMA-3 study, suggesting that therapeutic developments are needed to ensure more safe and potent options for adult B-ALL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Overt MFI developed in 3 pts, 2 of them needed hematopoietic stem cell transplantation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overt", "MFI", "developed", "in", "3", "pts", ",", "2...
PMC8193046	The computer-aided pattern analysis (C@PA) to predict multitarget ABCB1, ABCC1, and ABCG2 inhibitors was very recently reported .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "computer-aided",...
PMC11394227	Consequently, this study applied this approach to CHO antibody-producing cell lines to improve the efficiency of antibody folding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "this", ...
PMC11591038	Using fibroblasts lacking PS1, the induction of HIF-1α was impaired in response to cobalt chloride, which is known to stabilize HIF-1α under normoxia, or by insulin .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Rapid and deep hematological responses were recorded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rapid", "and", "deep", "hematological", "responses", "were", "recorded", "." ] } ]
PMC11628309	VMAT2, a transporter crucial for the synaptic vesicular packaging of monoamines such as serotonin, norepinephrine, histamine, and dopamine, has emerged as an important target for PD treatment (Eiden and Weihe, 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Furthermore, high expression of sEV-related genes correlated with poor survival and clinical parameters in CLL patients, suggesting sEV profiling as prognostic tool in CLL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11521786	Scale bar, 1 cm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "1", "cm", ".", "(" ] } ]
PMC11740573	Asterisk indicates the statistical differences: * P < 0.05 Fig. 6Average MIC value of Moxifloxacin alone and in association with calcitriol against strains of (EC) E. coli, (EF) E. faecalisand (GBS) S. agalactiae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	Our results using edgeR-v4 are presented in Figure 4 for three, five and ten samples per group and in Supplementary Figure S11 for 100 samples per group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11021472	Relative cell growth was assessed by following the percentages of BFP cells in the GFP fraction over three weeks post-transfection, with the percentages normalized to day 4 after transfection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682172	Using Anova analysis, the proteins that were differentially expressed in the comparison between yes/no co-culturing were listed according to p-value (right column).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11216402	Correlation of GC cell line chromatin accessibility profiles (gkm-SVM weights trained on cell line ATAC-seq) with healthy ENCODE lung fibroblasts and stomach (gkm-SVM trained using DNase-seq).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786600	Excellent biocompatibility is essential for the use of electrospun filaments in biological dressings.31 To assess the cytocompatibility of various dressing groups (gauze, PED0, PED2, and PED4), we utilized NIH/3T3 fibroblasts, which are typical for tissue healing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	We then used live-cell single-molecule imaging experiments to demonstrate that as predicted by our model, a fast overall fixation rate of POI relative to its puncta-binding dynamics can minimize fixation artifacts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Surprisingly, these effects could be restored with phenylalanine supplementation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Surprisingly", ",", "these", "effects", "could", "be", "restored", "with", "phenylalanine", "sup...
PMC11672142	This redox cycling potential warrants further study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "redox", "cycling", "potential", "warrants", "further", "study", "." ] } ]
PMC11635519	We also observed the colocalization of MCP1 and CCR2 at the cell surface upon transient coexpression in HEK293 cells using FRET assays (Figure 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11116779

Our investigation unveiled that PS-NPs markedly decreased cell viability in a concentration-dependent manner.

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PMC10547921

Figure 2Milestones in the development of ADCs payloads.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "2Milestones", "in", "the", "development", "of", "ADCs", "payloads", "." ] } ]

PMC9429973

Glofitamab-related AEs leading to discontinuation were uncommon (3 patients, 3%).

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PMC10094992

Aldehyde dehydrogenase 1A3 (ALDH1A3), one of the three members of the aldehyde dehydrogenase 1A subfamily, has been associated with increased progression and drug resistance in various types of solid tumours.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8557138

To fulfill the energy demands of the cell, rapidly proliferating tumor ECs are known to exist in a hyper glycolytic state by overexpressing phosphofructo-2-kinase/fructose 2,6 bis-phosphatase 3, the glycolytic regulatory enzyme (Cantelmo et al. 2016).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Clinical responses were assessed according to modified International Working Group (IWG) 2003 response criteria.

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PMC11752767

Other forms of ACT include B cells, NK cells, macrophages, and dendritic cells.

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PMC9429973

Aims: Macrocytosis is one of the cytological hallmarks of dyserithropoiesis in MDS: an analysis of the erythropoietic response to ESAs therapy in a cohort of anemic non trasfusion-dependent MDS patients, enrolled in a retrospective register, RECAMDS, subgroup of Italian register, was performed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740508

2Talazoparib plus decitabine treatment potentiates cumulative DNA damage in HRR deficient cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2Talazoparib", "plus", "decitabine", "treatment", "potentiates", "cumulative", "DNA", ...

PMC11684297

The MTT assay results (Fig. 3c) and cell counting by live-dead assay (Fig. 3d) also concluded that the as-synthesized ZnO-NFs could not induce any significant cell killing in the PC12 cells compared to the untreated control.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11082662

no. 15596026; Invitrogen), penicillin and streptomycin (cat.

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PMC11310713

Our method suggests that cell-based hormone therapy may mitigate the risk of breast cancer, a major side effect associated with pharmaceutical HRT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", ...

PMC9429973

TPE could be considered as a therapeutic intervention that can reduce thrombotic risk in patients necessitating an urgent non-cardiac surgery in the acute phase of HIT.

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PMC11680049

From the histochemical studies presented above, it follows that the studied Sequoia plants are characterized by a high ability to form secondary metabolites of various natures.

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PMC11633763

Significant differences between two groups were determined using the Student's t‐test, while comparisons between more than two groups were performed using single‐factor analysis of variance (ANOVA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6267596

Diffuse large B-cell lymphoma (DLBCL), an aggressive form of B-cell non-Hodgkin lymphoma (B-NHL), is the most common subtype in adults (∼30%) with ∼45,000 new cases per year.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11700523

Second, the role of IS in other CKD models, such as diabetes and hypertension, also remains to be investigated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Second", ","...

PMC11252033

Regarding acquired resistance, the deregulation of anti-apoptotic genes Bcl-2 and Bcl-xL has been well established (Dai et al., 2023; Karademir and Özgür, 2023).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The serum levels of IL-27 in CLL patients and sick mice were quantified via ELISA and compared to those of healthy controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "serum...

PMC10944868

Understanding the factors that influence drug absorption is essential for optimizing drug therapy and minimizing adverse effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "the", "factors", "that", "influe...

PMC11638764

Dynamic exclusion was set to 30 s. The temperature of ion transfer tube was 300°C and the S-lens RF level was set to 30.

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PMC9243326

The trial was performed in accordance with the Institutional Animal Care and Use Committees of Guangxi Academy (CGA-00927).

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PMC11769516

Scientists also analyzed extracts of cow feed, identifying “regulated” and “emerging” mycotoxins.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scientists", "also", "analyzed", "extracts", "of"...

PMC8358176

Administration of SWCNTs-COOH and MWCNTs-COOH could result in the up-regulation of TNF and TNFRSF10A but did not initiate apoptosis in Jurkat cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Administr...

PMC10976516

Costimulatory molecules, including CD40 and CD80, are present in professional APCs.

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PMC10713411

Kidney renal clear cell carcinoma (KIRC), the most prevalent type of RCC, accounts for approximately 80% of all RCC cases .

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PMC9429973

In 2018 the International T-cell non-Hodgkin’s Lymphoma Study Group launched the T-cell Project 2.0.

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PMC9429973

Overall, 370 genes were differentially expressed (p<0.05) in NR, as compared to R patients, of which 32 were significantly differentially expressed (corrected p < 0.05, FC ≥2).

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PMC11783017

To analyze memory T cells, the single cell suspensions harvested from spleens were respectively stained with PE-anti-CD8, FITC-anti-CD44 and APC-anti-CD62L antibodies to differentiate central memory T cells (TCM, CD8CD44CD62L) and effector memory T cells (TEM, CD8CD44CD62L).

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PMC11772449

After the cell growth was stable, the experimental treatment was performed.

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PMC9848491

In addition to immunotherapy, we also analyzed the association between the predictive signature and the efficacy of general chemotherapy for UCEC.

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PMC11775197

The function of PPARβ/δ in the context of cancer remains a topic of contention within the scientific community.

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PMC3734024

These complete data and a full description of the methods used to obtain the cell populations compared are freely available from the NCBI GEO depository (Accession number GSE46245).

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PMC6182045

The production of TZ97008 rgp120 in the MGAT1 CHO line provided almost four-fold improvement in Kd of PGT128 binding, six-fold improvement in Kd of PG9 binding, and over ten-fold improvement in Kd of VRC01 binding (Table 2).

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PMC9429973

L. Hebert, P. Shah, O. Diaz, A. A. Street, J. Li, E. Rudenko, A. M. Zlotnicki, C. Morrison, R. Bomben, Y. Huang, A. Medina Herrera, A. Wong, S. Gleen R&D; BioInformatics, Invivoscribe, San Diego; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, United States of America; Clinical and Experimenta...

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PMC11741906

HR values greater than 1 indicate poor outcome and hazard increase while HR values below 1 indicate good outcome and hazard reduction, whereas HR values equal to 1 indicate no differences in hazard between groups.

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PMC11244823

Each potential control serum was tested against each of the available antigens.

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PMC9429973

The majority had moderate or severe lung tissue damage (CT2 in 44 (33%), CT3 in 25 (20%), CT4 in 13 (10%)).

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PMC9429973

L. I. Gordon, D. Hoda, L. Shi, S. Guo, F. F. Liu, J. Braverman, R. Dubowy, L. Peng, A. Sehgal Northwestern University, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago; Intermountain Healthcare, Loveland Clinic for Blood Cancer Therapy, Salt Lake City; Evidera, Waltham; Bristol Myers Sq...

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PMC8632470

The WST-8 assay showed that the cytotoxicity IC50 of ASE = 2322 μg/mL and IC50 of ALE = 2283 μg/mL. The nephroprotective activity assay revealed that ASE possesses nephroprotective activity against the NAPQI-induced HEK293 cell line at 1161 μg/mL, while ALE does not show the nephroprotective activity.

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PMC8984067

The photosensitizer chlorin e6 (Ce6) and anti-EpCAM were further assembled over UCNP surfaces through the formation of amide linkage, constructing an anti-EpCAM-UCNPs-Ce6 nanoplatform, which was identified through X-ray diffraction (XRD), transmission electron microscopy (TEM), infrared spectrum (IR), and UV-Vis spectr...

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PMC11317131

K562 cells (4 × 10) were seeded in 6-well plates.

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PMC9429973

Median GAD-7 score of all subjects was 5 (range 0-21), with 81 (49.7%), 44 (27%), 31 (19%) and 7 (4.3%) of subjects having no, mild, moderate and severe anxiety symptoms, respectively (Figure 1).

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PMC11395280

A significant complication of pediatric T-ALL is CNS invasion where the leukemic cells can hide during standard chemotherapy regimens, resulting in disease recurrence.

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PMC5963610

Furthermore, a positive clinical outcome is reported for a cancer patient treated with the combination of an anti-EGFR mAb and anti-NGcGM3 therapy.

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PMC11746948

The results demonstrated that the APT2 inhibitor ML349 substantially reduced liver injury caused by ischemia-reperfusion, paralleling the effects of Lip-1 (Fig. 8e–g).

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PMC11401358

There was no significant difference between (GAGSGA)2-8 h and SF in scavenging capacity at 1 mg/mL, although the scavenging capacity of (GAGSGA)2-8 h was lower than the scavenging capacity of SF at 0.01 mg/mL. We further confirmed by flow cytometry that both (GAGSGA)2-8 h group and SF group reduced ROS levels at the ce...

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PMC8662250

In addition to these previous publications, our study first demonstrates, as far we know, new and potential effects of CBD in the intestinal epithelium, potentially able to counteract SARS‐CoV‐2 hyper‐inflammation in the gut.

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PMC11489175

In this context, a role for DUBs in specific tumor types such as ovarian cancer is clearly emerging.

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PMC11750696

In the absence of stress, these proteins are maintained in an inactive form by the binding with the chaperone BiP. However, upon unfolded protein accumulates within the ER, it promotes the release of BiP, thereby activating these sentinels and initiating the UPR (7).

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PMC7642379

Based on the growth characteristics, cells were divided into two groups of adherent and suspension cells.

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PMC9599726

Drug concentrations were chosen based on previous studies .

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PMC11467800

Representative examples of fluorescence microscopy images of larval xenografts at 2 dpi.

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PMC9429973

A different approach is the use of the antigen binding domain of the antibody in chimeric antigen receptors (CARs) expressed in NK or T cells to induce cellular cytotoxicity against ROR1-expressing cancer cells.

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PMC4270159

To provide a baseline.

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PMC11687663

Extractive yield was estimated as: % Extractive yield = (weight of dry extract / initial weight of dry sample) × 100 The yield obtained from A. helferiana was 22.81% w/w.

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PMC8922418

In the process of gene editing, multi-approaches can be utilized to making cells resistant against HIV-1 infection.

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PMC11679326

An interesting feature of metastatic colorectal cancer cells is the prevalence of α2,6-linked sialic acid residues in N-glycans, while α2,6-linked sialic acid residues mediate integrin-dependent adhesion of hepatocarcinoma cells to fibronectin and also promote adhesion of melanoma cells to extracellular matrix componen...

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PMC7709199

The GD cell line is derived from the HEK293S MGAT1 cell line and has been transformed with Golgi-resident EndoT (an endo-β-N-acetylglucosaminidase similar to EndoH).

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PMC11564322

Interestingly, the c-SRC inhibitor I used alone increased KI67 mRNA only in HL-60 and MEG-A2 (by 24.95 and 49.54%, respectively, compared to the control).Fig.

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PMC8584666

Moreover, it has also been reported that GPI-80 is associated with malignant tumors .

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PMC9429973

EDSS score was 1.5 – 7.5 (average 4.5).

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PMC11201245

5.8, Metasystems, Altlusheim, Germany).

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PMC9712534

As for TOP2B, a number of germline missense mutations were identified as causative for human diseases.

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PMC11180402

Transcription factor expression in 5637 cells treated with ISO at indicated times. (

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PMC11674834

Differences in ROS levels among the CHO cell lines were slight and non-significant (p > 0.05) but followed the pattern UV5 > UV5/1A2 > UV5/1A2/NAT1*4 > UV5/1A2/NAT1*14B (Figure 3).

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PMC11474209

The disruption of mitochondrial-nuclear crosstalk highlights significant concerns for cellular health and underscores the need for further investigation into these mechanisms.

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PMC9960565

The remaining cisplatin-metallodendrimers were characterized by ESI in the positive mode.

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PMC11760643

ATP‐induced responses were calculated by subtracting the corresponding basal response.

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PMC11472639

In the absence of clonal plasma cell mobilisation into blood in response to exercise and given that the bulk of myeloma cells reside in the bone marrow (Kyle et al., 2003), it may be that a preferential redistribution of NK-cells and monocytes to bone after exercise – as is seen with T-cells (Krüger et al., 2008) – is ...

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PMC9429973

WBC at diagnosis was<4000 in 5 cases, 4000-10000 in 2 cases, between 10000-50000 in 7 cases, and >50000 in 1 case.

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PMC11718817

The presence of M2 macrophages and MDSCs has been shown to render tumors less susceptible to PD-1 blockade .

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PMC11078693

All resources reported are US sources.

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PMC11477621

Then, the mixture was quenched with H2O (15 mL) and extracted with dichloromethane (3 × 10 mL).

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PMC11411131

Krab-Sec (or Krab-Cys) contained the cytomegalovirus (CMV) or EF1α promoter, while luciferase employed the CMV, SV40, or TK promoter.

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PMC11367146

After scratching, the well was washed twice with medium to remove the detached cells.

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PMC11591038

In the low-dose simvastatin group, the reduced expression of HIF-1α and BACE1 was observed in the SAD cybrids as compared to the controls.

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PMC9960565

In this sense, dendrimers are at the forefront, as they have shown potential for use as drug delivery systems .

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PMC11564405

In the arena of statistical examination, we engaged in a comprehensive analysis facilitated by the robust tools of GraphPad Prism 7 and SPSS 22.0 software.

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PMC11781181

Images were captured with an H-7500 electron microscope (Hitachi, Tokyo, Japan).

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PMC9429973

Hemoglobins were analyzed by capillary zone electrophoresis (Sebia Capillarys Flex system) and ion exchange HPLC (BioRad Variant II β-thalassemia Short Program).

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PMC9429973

CRS occurred in 92% patients, and neurologic toxicities occurred in 87% patients in ZUMA-3 study, suggesting that therapeutic developments are needed to ensure more safe and potent options for adult B-ALL.

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PMC9429973

Overt MFI developed in 3 pts, 2 of them needed hematopoietic stem cell transplantation.

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PMC8193046

The computer-aided pattern analysis (C@PA) to predict multitarget ABCB1, ABCC1, and ABCG2 inhibitors was very recently reported .

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PMC11394227

Consequently, this study applied this approach to CHO antibody-producing cell lines to improve the efficiency of antibody folding.

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PMC11591038

Using fibroblasts lacking PS1, the induction of HIF-1α was impaired in response to cobalt chloride, which is known to stabilize HIF-1α under normoxia, or by insulin .

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PMC9429973

Rapid and deep hematological responses were recorded.

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PMC11628309

VMAT2, a transporter crucial for the synaptic vesicular packaging of monoamines such as serotonin, norepinephrine, histamine, and dopamine, has emerged as an important target for PD treatment (Eiden and Weihe, 2011).

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PMC9429973

Furthermore, high expression of sEV-related genes correlated with poor survival and clinical parameters in CLL patients, suggesting sEV profiling as prognostic tool in CLL.

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PMC11521786

Scale bar, 1 cm. (

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PMC11740573

Asterisk indicates the statistical differences: * P < 0.05 Fig. 6Average MIC value of Moxifloxacin alone and in association with calcitriol against strains of (EC) E. coli, (EF) E. faecalisand (GBS) S. agalactiae.

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PMC11532793

Our results using edgeR-v4 are presented in Figure 4 for three, five and ten samples per group and in Supplementary Figure S11 for 100 samples per group.

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PMC11021472

Relative cell growth was assessed by following the percentages of BFP cells in the GFP fraction over three weeks post-transfection, with the percentages normalized to day 4 after transfection.

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PMC11682172

Using Anova analysis, the proteins that were differentially expressed in the comparison between yes/no co-culturing were listed according to p-value (right column).

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PMC11216402

Correlation of GC cell line chromatin accessibility profiles (gkm-SVM weights trained on cell line ATAC-seq) with healthy ENCODE lung fibroblasts and stomach (gkm-SVM trained using DNase-seq).

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PMC11786600

Excellent biocompatibility is essential for the use of electrospun filaments in biological dressings.31 To assess the cytocompatibility of various dressing groups (gauze, PED0, PED2, and PED4), we utilized NIH/3T3 fibroblasts, which are typical for tissue healing.

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PMC9817179

We then used live-cell single-molecule imaging experiments to demonstrate that as predicted by our model, a fast overall fixation rate of POI relative to its puncta-binding dynamics can minimize fixation artifacts.

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PMC11365427

Surprisingly, these effects could be restored with phenylalanine supplementation.

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PMC11672142

This redox cycling potential warrants further study.

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PMC11635519

We also observed the colocalization of MCP1 and CCR2 at the cell surface upon transient coexpression in HEK293 cells using FRET assays (Figure 2C).

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