OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11634027	CRISPR-Cas9-mediated recombination was used to replace exon 12 with an RMCE cassette including an RFP gene flanked by attP sites in the upstream intron and 3′ UTR (Fig. S2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184	However, if PEF treatment results in only partial response, the treatment needs to be repeated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "if", "PEF", "treatment", "r...
PMC11055510	This makes them a popular cell model for studying aspects such as gene expression, protein function, and cell signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "makes", "...
PMC11795610	p < 0.05, p < 0.01, and *p < 0.001 versus NOR group; p < 0.05, p < 0.01, and p < 0.001 versus high Ca group; ns indicated no statistically difference as compared to the high Ca group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11738017	Whole-genome sequencing was performed as previously reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole-genome", "sequencing", "was", "performed", "as", "previously", "reported", "." ] } ]
PMC11033180	Remaining fluorescence was measured as destaining fraction, after 4 min exposure to KCl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remaining", "fluorescence", "was", "measured", "as", "destaining", "fr...
PMC9429973	Although randomized controlled trials have demonstrated the clinical efficacy and safety of eculizumab, there is a paucity of real-world effectiveness data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "...
PMC11495567	Cancers driven by mutant RAS proteins have been considered undruggable until recently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancers", "driven", "by", "mutant", "RAS", "proteins", "have", "been", "consider...
PMC9621239	A total of 1 × 10 Huh 7 cells were seeded and cultured for 12 h in each well of a 96-well plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens"...
PMC11354239	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC5716223	p < 0.05 Effects of NGF supplementation on L6C5 in vitro differentiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "Effects", "of", "NGF", "supplementation", "on", "L6C5...
PMC11754291	A significant reduction in mitochondrial activity was observed in keratinocytes with the strongest light parameter of 50 mW/cm, 50 J/cm, particularly by day 7, where the AlamarBlue signal decreased to 0.86 ± 0.055 (mean ± SD), representing a fold decrease compared to the respective sham (Figure 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	ORR was 83% (acala) vs 84% (IdR/BR) (ORR + partial response with lymphocytosis: 92% [acala] vs 88% [IdR/BR]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We previously reported an objective response rate (ORR) of 89% in 95 patients receiving standard-of-care brexu-cel in the US Lymphoma CAR T Consortium (Wang et al, ASH 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: To address this hypothesis, we studied a pool of EBV seropositive donors (HI donor n= 4; NI Donor n=5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10454535	RES derivatives and BTZ were screened for their cytotoxic effects in constant ratio combinations of 1:1000 BTZ to RES derivative (0 nM/0 μM, 5 nM/5 μM, 10 nM/10 μM, 20 nM/20 μM, 30 nM/30 μM, 50 nM/50 μM) as well as 5, 10 and 20 μM concentrations of RES derivatives with 1.25, 2.5, 5, 10 and 20 nM concentrations of BTZ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7802142	e Immunofluorescence images of β-catenin (red) in HFs from mice receiving depilation and 6-day subcutaneous injection (once per day).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "e", ...
PMC9429973	Aims: We aimed to characterise the relevant parameters of the mesenchymal cell-derived ECM generated by MSCs from healthy donor and MDS patient bonemarrow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7351993	Supplementary Fig. 3d shows the image and its cross sections in the parallel (x) and perpendicular (y) directions to the flow, indicating that the widths of the edges are less than 2 µm in both the x and y directions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9261184	Results of the measurement study are first presented by describing total GHG emissions and then split by the voyage stage, by the GHG (methane or CO2), and by the emissions source to characterize the emissions profile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11323699	Subsequently, subcutaneous tumors (black bar, SC model), peritoneal tumor masses, and metastatic nodules (pink and brown bars, respectively, IP model) were excised post euthanasia and then imaged for TAX2-Cy5 quantification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	This element is of clinical interest as it harbors a mutation that co-segregates with Van der Woude syndrome in a family and that diminishes the periderm-enhancer activity of the element containing it (Fakhouri et al., 2014); it also harbors a single nucleotide polymorphism associated with risk for non-syndromic orofac...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	Cell proliferation assay and transwell assay were performed according to the our published methods .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "proliferation", "assay", "and", "transwell", "assay", "were", ...
PMC9429973	V. Filipponi, M. Antonacci, M. C. Scerpa, U. Coppetelli, S. Perrone, N. Cenfra, S. Mecarocci, L. Fiori, F. Brinchi Giusti, P. Giovangrossi, F. Equitani, E. Ortu La Barbera, G. Cimino Department of Translational and Precision Medicine, Hematology, Sapienza University of Rome, Rome; Hematology Unit Santa Maria Goretti Ho...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699178	A Visualization of cell annotation results grouping on UMAP clustering; B Correlation heatmaps of top five genes in 13 cell types; C, D KEGG E and GO F functional enrichment plots of epithelial cell characteristic genes; E Cell communication network plot in samples, where thickness of lines in the left plot represents ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674834	In previous studies, we used nucleotide excision repair (NER)-deficient Chinese hamster ovary cells (CHO) cells that express human CYP1A2 and NAT1 reference or variant alleles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11451940	In addition to the cell-based models, we strived to understand the redox-processes that are involved in the interaction of the complexes, and therefore we performed measurements of cyclic voltammograms (see Fig. S24 and Table S5 in the ESI‡) of the representative complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	Xenograft specimens resected from animals treated with NPB exhibited significantly reduced pBADS99-positive cells in both A2780 and A2780cisR cell-derived xenografts compared to vehicle-treated control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], ...
PMC11747467	Western blot analysis revealed STAT3 and pSTAT3 (Tyr705) expression after exposure to different concentrations of ART. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "re...
PMC11687663	PPAR-δ is crucial in the pathophysiology of HCC along with the role in metabolic process .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PPAR-δ", "is", "crucial", "in", "the", "pathophysiology", "...
PMC9596868	Quercetin binds to DNA via intercalation and causes double strand breaks thus affecting DNA metabolism .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quercetin", "binds", "to", "DNA", "via", "intercalation", "...
PMC9429973	Approximately 500 patients will be randomized 1:1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "500", "patients", "will", "be", "randomized", "1:1", "." ] } ]
PMC11564405	RILPL2 expression was significantly related to clinical stage (P = 0.019), and low RILPL2 expression indicated higher stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RILPL2", "expression", ...
PMC7759933	However, in larger spheroids, small patches of death cells started to occur approximately on day 4 and by day 6, reached 16.5% dead cells on average with the visible formation of a necrotic core.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	Detectable levels in the brain and adipose tissues suggested penetration of the blood‒brain barrier (Liu and Huang, 1988).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detectable", "levels", ...
PMC3888431	If more than one ORF of a transcript had a significant hit, the hit with the highest score was chosen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "If", "more", "tha...
PMC11473750	However, knocking down RNF121 did not result in reduced MYCN mRNA expression levels (Fig. 5c), suggesting that the interaction between MYCN and RNF121 was post-translation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792766	The investigation emphasizes conventional bioassays used to evaluate cytotoxic potency on HepG2 and Caco‐2 cell lines, which are commonly employed for assessing hepatotoxicity and colon toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11727062	Artemisinin, a sesquiterpene lactone with diverse pharmacological properties, perturbs mitochondrial homeostasis in neoplastic cells and modulates the secretion and functionality of angiogenic factors via autocrine and paracrine signaling pathways, thereby inhibiting tumor-associated angiogenesis and preventing the epi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	Data are means ± SD; n = 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "means", "±", "SD", ";", "n", "=", "3", "." ] } ]
PMC5716223	2Effects of NGF supplementation on L6C5 in vitro differentiation.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "2Effects", "of", "NGF", "supplementation", "on", "L6C5", "in", "vitro", "differentiation", "." ...
PMC9164404	D Tumor growth inhibition curves of mice treated with PBS, cisplatin, and Abplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Tumor", "growth", "inhibition", "curves", "of", "mice"...
PMC10522430	Following this, a thrice-repeated washing step was undertaken using a washing buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "this", ",", "a", "thrice-repeated", "washing", "step", "was", ...
PMC9429973	We compared Ly subsets before and after the completion of the two doses of vaccination schedule: interestingly, after the second dose, R exhibited significantly higher total Ly counts, CD3+, CD4+ and CD19+ (Fig.1I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Data presented as mean ± SEM, n = 3 (Saline + IgG2a); n = 4, (Saline + anti-GD2, TETA + anti-GD2), n = 5 (TETA + IgG2a) biological replicates with three technical replicates, one independent experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	no significance; ****p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no", "significance", ";", "", "", "", "", "p", "<", "0.0001", "." ] } ]
PMC10993311	The 17 cellular components identified by functional annotation of the DMRs can be found in Table S3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "17", "cellular", "components", "identified...
PMC10006224	Previous results in yeast had shown that cohesin could be detected at loading sites in scc2 mutants by chromatin immunoprecipitation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "results", "in", ...
PMC11075223	−)-syringaresinol (274), (+)-isolarisiresinol 3-O-β-D-glucoside (275), syringaresinol di-O-β-D-allopyranoside (276) belong to dibenzylbutane, arylnaphthalene, dibenzyltyrolactone, respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10944868	In the case of our tested compounds, it should be noted that all derivatives present the necessary conditions to be PGP-substrate candidates (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	The experiment was conducted in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "experiment", "was", "conducted", "in", "triplicate", "." ] } ]
PMC10440586	But this inclination was not reflected by post-dosing CD99 expression (Supplementary Figure 5 G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "But", "this", "inclination", "was", "not", "reflected"...
PMC8526701	Noncancer cell lines HEK293 and NCM356 cells were highly resistant to BRD9 inhibition (Fig. S1A and B).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Noncancer", "cell", "...
PMC8839885	Briefly, human OC cell lines A2780 and A2780CisR were plated at 8 × 10 cells/cm in 25 cm or 75 cm cell-culture flasks and incubated in culture medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11283030	Secondly, the shortcoming is the lack of direct interaction through flow cytometry or immunoprecipitation (IP) of ACLY with immune cells or immune inhibitors in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10545062	After a laparotomy and cystostomy tube placement, a splenectomy was performed to minimize hemodynamic variation from autotransfusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "a", "laparotomy", "and", "cys...
PMC11402217	Scale bars = 10 μM. Western blotting results (I) and the normalized quantitative results (J) of overexpression Dkk1 transfected 143B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ],...
PMC8973085	White solid [A] (90%), [B] (65%); mp: 201–204 °C (EtOH); IR (KBr, v, cm): 3240 (NH), 2221 (CN), 1747 (C=O), 1636 (C=O); H NMR (DMSO-d6): δ 1.26 (t, 3H, CH3), 2.55 (s, 3H, CH3), 3.70 (s, 3H, OCH3), 3.74 (s, 3H, OCH3), 4.17 (s, 2H, CH2), 4.19 (q, 2H, CH2), 6.95–7.46 (m, 7H, CH-Ar), 10.52 (bs, 1H, NH); C NMR (DMSO-d6): δ ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	Here, by using a combination of structural, biophysical, and cellular data, we have examined the ORF4b interaction with different IMPα isoforms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10882807	Patients who received surgical treatment without any other treatment were chosen for the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "received", "surgical", "treatment", "without", "any...
PMC11772449	At the same time, the gray value of WB results was statistically analyzed by ImageJ software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "same", "time", ",", "the", ...
PMC9429973	Image: Summary/Conclusion: Our data indicate that mitapivat was at least as effective as splenectomy in treatment of anemia in a murine model of HS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11095939	Co-IP using Mecp2 antibody revealed that Mecp2-associated ubiquitin and Nedd4 were dramatically increased at 3 hr and 6 hr post-SR (Figure 5B), suggesting that Nedd4 interacts with Mecp2 to induce the polyubiquitination and degradation of Mecp2 upon cell cycle reentry. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Accordingly, after their deletion, the ability of c-Fos to recognize the promoter was overcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accordingly", ",", "after", "their", "deletion", ",", ...
PMC11673902	With the application of high-speed imaging or electrical impedance measurement, a higher throughput can be achieved compared to most other deformability measurement methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8873393	D Heat-map diagram showing the six clusters of differentially expressed transcripts in the chromatin extract following UV exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Heat-map", "diagram", "showing", ...
PMC11467800	These interactions result in the emergence of distinct cellular adaptive states, which subsequently influence tumour growth, invasion, metastasis and response to therapy. , , ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	ATF3 regulates CHOP expression either directly or indirectly, and CHOP, in turn, can regulate ATF3 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ATF3", "regulates", "CHOP", "expr...
PMC11351758	The mitochondria have complexes, identified as I, II, III, IV, and V, and any anomaly to these complexes also leads to reactive oxygen species production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	For example, Qian et al showed that mouse astrocytes were converted to functional dopaminergic neurons by depleting the RNA binding protein PTBP1, and then Parkinson’s disease-relevant motor phenotypes were reversed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	Statistical analysis of ROS levels and inflammatory cells in G. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11093197	Cells were analyzed by FACSCanto Flow Cytometer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "analyzed", "by", "FACSCanto", "Flow", "Cytometer", "." ] } ]
PMC10024132	p < 0.05, **p < 0.01.Fig 3 Blinatumomab DNA-transduced γ9δ2 T cells exert robust in vitro anti-tumor activity against CD19-expressing tumor cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5417661	Addition of VEGF (20 ng/mL +0.1% DMSO) increased the peak mean cord length to 8.7±0.5 mm/mm and peak mean branch point to 47.6±4.4 mm/mm (Figures S2 and 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10933092	Newly diagnosed cases present with non-muscle-invasive bladder cancer (NMIBC), which is usually treated by transurethral resection and intravesical therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Newly", "dia...
PMC11742670	From this DRY LAB phase, the selected compounds were examined against the same cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "this", "DRY", "LAB", "phase", ",", ...
PMC11420784	NDP52, which contains an LC3-interacting motif and a ubiquitin-binding domain, recruits the autophagy machinery to create a phagophore surrounding intracellular bacteria .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NDP52",...
PMC11791432	Yanwen Chen: Writing – original draft, Funding acquisition, Formal analysis, Data curation, Conceptualization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yanwen", "Chen", ":", "Writing", "–", ...
PMC11756514	The present report demonstrates that langerin, MBL, and SP-D can bind to S. aureus, but MGL cannot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "present", ...
PMC11682172	Co-culturing experiments were repeated twice for proteomics and genomics measurements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Co-culturing", "experiments", "were", "repeated", "twice", "for", "proteomics", "and", "genomics", ...
PMC6222726	Compound 32 was already known as a synthetic derivative of podophyllotoxin but it was new as a natural product.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "32", "was", "already"...
PMC11774112	A bicinchoninic acid (BCA) assay kit was acquired from Pierce (Rockford, IL, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "bicinchoninic", "acid", "(",...
PMC11705630	Glycine decarboxylase (GLDC) is a mitochondrial enzyme that takes part in the oxidation of glycine to support nucleotide biosynthesis via transfer of one-carbon units.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3122064	In contrast, other studies have failed to support a role for p53 in TC responsiveness, although the involvement of the MDM2–p53 complex in the response to chemotherapy had not been thoroughly assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588008	Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance with the tenets of the Helsinki Declaration, and has been approved by the Institution Review Board, Tianjin Central Hospital of Obstetrics and Gynecology (No. 2020KY...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705862	The disorder is neuropathologically characterized by the presence of senile plaques and neurofibrillary tangles (NFTs), where the former arise due to an accumulation of amyloid beta (Aβ) and the latter is a result of intra-neuronal accumulation of hyperphosphorylated tau (p-tau).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD016244.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mass"...
PMC10898159	Moreover, LIX1 can controls MAPK signaling pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "LIX1", "can", "controls", "MAPK", "signaling", "pathway", "." ] } ]
PMC11300639	Being fixed with 4% paraformaldehyde for 15 min, the cells were subsequently incubated with anti-RNF26 (#16802-1-AP, Proteintech, 1:200 dilution) or anti-TSC1 (#29906-1-AP, Proteintech, 1:250 dilution) antibody at 4 °C overnight, and washed several times with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	This USP43 association promotes HIF-1 accumulation in the nucleus, and is required for the efficiency of HIF-1 to HREs on chromatin to activate gene transcription.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9454852	Such a view is further corroborated by our finding of GRP78 expression at the cell surface, and in addition by the observed positive correlation between cell surface GRP78 levels and the degree of AKT phosphorylation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median day of apheresis was D+26 from the start to chemotherapy (range 22-39).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "day", "of", "apheresi...
PMC11694625	The results revealed that 3a–3d all had potential anticancer activity, while exhibiting no discernible effect on normal human liver cells HL-7702.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "The", ...
PMC10898159	AMPD3, belonging to the adenosine monophosphate deaminases (AMPDs), functions as a main catalyzer which hydrolytically deaminates AMP to inosine monophosphate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11201245	The relative 5-year survival rate is about 40%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "5-year", "survival", "rate", "is", "about", "40", "%", "." ] } ]
PMC11621565	Between 1.25 and 80 µg/ml no decrease in MTS value was seen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Between", "1.25", "and", "80", "µg/ml", "no", "decrease", "in", "MTS", "va...
PMC11365983	Only small numbers of transcription factors have been identified in vertebrates: including the Rfx gene family (Rfx1-4), and two Forkhead Box (FOX) family members (Foxj1 and Foxn4) that directly regulate development of motile cilia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11435360	After 24 h in normal culture conditions, cells were subjected to 0, 8, or 36 h of hypoxia (5% CO2, 0.5% O2, 95% N2) at 37 °C using a HypOxystation H85 hypoxia chamber (HYPO2YGEN, Frederick, MD, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	M. Wobus, E. Balaian, M. Lissner, R. Towers, U. Oelschlägel, R. Wehner, T. Chavakis, M. Törngren, H. Eriksson, E. Bondesson, U. Platzbecker, M. Bornhäuser, K. Sockel Department of Medicine 1, University Hospital TU Dresden, Dresden; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Cente...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	S. Kapustin, A. Chechulova, J. Drijun, S. Svitina, V. Burakov, V. Soroka, V. Soldatenkov, L. Papayan Russian Research Institute of Hematology and Tranfusiology, Saint-Petersburg; Dzhanelidze Research Institute of Emergency Medicine, Saint Petersburg; Dzhanelidze Research Institute of Emergency Medicine, Saint-Petersbur...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11634027

CRISPR-Cas9-mediated recombination was used to replace exon 12 with an RMCE cassette including an RFP gene flanked by attP sites in the upstream intron and 3′ UTR (Fig. S2A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7305184

However, if PEF treatment results in only partial response, the treatment needs to be repeated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "if", "PEF", "treatment", "r...

PMC11055510

This makes them a popular cell model for studying aspects such as gene expression, protein function, and cell signaling.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "makes", "...

PMC11795610

p < 0.05, **p < 0.01, and ***p < 0.001 versus NOR group; p < 0.05, p < 0.01, and p < 0.001 versus high Ca group; ns indicated no statistically difference as compared to the high Ca group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11738017

Whole-genome sequencing was performed as previously reported.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole-genome", "sequencing", "was", "performed", "as", "previously", "reported", "." ] } ]

PMC11033180

Remaining fluorescence was measured as destaining fraction, after 4 min exposure to KCl.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remaining", "fluorescence", "was", "measured", "as", "destaining", "fr...

PMC9429973

Although randomized controlled trials have demonstrated the clinical efficacy and safety of eculizumab, there is a paucity of real-world effectiveness data.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "...

PMC11495567

Cancers driven by mutant RAS proteins have been considered undruggable until recently.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancers", "driven", "by", "mutant", "RAS", "proteins", "have", "been", "consider...

PMC9621239

A total of 1 × 10 Huh 7 cells were seeded and cultured for 12 h in each well of a 96-well plate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens"...

PMC11354239

.

[ { "tags": [ "O" ], "tokens": [ "." ] } ]

PMC5716223

p < 0.05 Effects of NGF supplementation on L6C5 in vitro differentiation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "Effects", "of", "NGF", "supplementation", "on", "L6C5...

PMC11754291

A significant reduction in mitochondrial activity was observed in keratinocytes with the strongest light parameter of 50 mW/cm, 50 J/cm, particularly by day 7, where the AlamarBlue signal decreased to 0.86 ± 0.055 (mean ± SD), representing a fold decrease compared to the respective sham (Figure 6A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

ORR was 83% (acala) vs 84% (IdR/BR) (ORR + partial response with lymphocytosis: 92% [acala] vs 88% [IdR/BR]).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

We previously reported an objective response rate (ORR) of 89% in 95 patients receiving standard-of-care brexu-cel in the US Lymphoma CAR T Consortium (Wang et al, ASH 2021).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: To address this hypothesis, we studied a pool of EBV seropositive donors (HI donor n= 4; NI Donor n=5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10454535

RES derivatives and BTZ were screened for their cytotoxic effects in constant ratio combinations of 1:1000 BTZ to RES derivative (0 nM/0 μM, 5 nM/5 μM, 10 nM/10 μM, 20 nM/20 μM, 30 nM/30 μM, 50 nM/50 μM) as well as 5, 10 and 20 μM concentrations of RES derivatives with 1.25, 2.5, 5, 10 and 20 nM concentrations of BTZ.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7802142

e Immunofluorescence images of β-catenin (red) in HFs from mice receiving depilation and 6-day subcutaneous injection (once per day).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "e", ...

PMC9429973

Aims: We aimed to characterise the relevant parameters of the mesenchymal cell-derived ECM generated by MSCs from healthy donor and MDS patient bonemarrow.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC7351993

Supplementary Fig. 3d shows the image and its cross sections in the parallel (x) and perpendicular (y) directions to the flow, indicating that the widths of the edges are less than 2 µm in both the x and y directions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9261184

Results of the measurement study are first presented by describing total GHG emissions and then split by the voyage stage, by the GHG (methane or CO2), and by the emissions source to characterize the emissions profile.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11323699

Subsequently, subcutaneous tumors (black bar, SC model), peritoneal tumor masses, and metastatic nodules (pink and brown bars, respectively, IP model) were excised post euthanasia and then imaged for TAX2-Cy5 quantification.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7039683

This element is of clinical interest as it harbors a mutation that co-segregates with Van der Woude syndrome in a family and that diminishes the periderm-enhancer activity of the element containing it (Fakhouri et al., 2014); it also harbors a single nucleotide polymorphism associated with risk for non-syndromic orofac...

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PMC11794847

Cell proliferation assay and transwell assay were performed according to the our published methods .

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PMC9429973

V. Filipponi, M. Antonacci, M. C. Scerpa, U. Coppetelli, S. Perrone, N. Cenfra, S. Mecarocci, L. Fiori, F. Brinchi Giusti, P. Giovangrossi, F. Equitani, E. Ortu La Barbera, G. Cimino Department of Translational and Precision Medicine, Hematology, Sapienza University of Rome, Rome; Hematology Unit Santa Maria Goretti Ho...

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PMC11699178

A Visualization of cell annotation results grouping on UMAP clustering; B Correlation heatmaps of top five genes in 13 cell types; C, D KEGG E and GO F functional enrichment plots of epithelial cell characteristic genes; E Cell communication network plot in samples, where thickness of lines in the left plot represents ...

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PMC11674834

In previous studies, we used nucleotide excision repair (NER)-deficient Chinese hamster ovary cells (CHO) cells that express human CYP1A2 and NAT1 reference or variant alleles.

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PMC11451940

In addition to the cell-based models, we strived to understand the redox-processes that are involved in the interaction of the complexes, and therefore we performed measurements of cyclic voltammograms (see Fig. S24 and Table S5 in the ESI‡) of the representative complexes.

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PMC9250505

Xenograft specimens resected from animals treated with NPB exhibited significantly reduced pBADS99-positive cells in both A2780 and A2780cisR cell-derived xenografts compared to vehicle-treated control.

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PMC11747467

Western blot analysis revealed STAT3 and pSTAT3 (Tyr705) expression after exposure to different concentrations of ART. (

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PMC11687663

PPAR-δ is crucial in the pathophysiology of HCC along with the role in metabolic process .

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PMC9596868

Quercetin binds to DNA via intercalation and causes double strand breaks thus affecting DNA metabolism .

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PMC9429973

Approximately 500 patients will be randomized 1:1.

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PMC11564405

RILPL2 expression was significantly related to clinical stage (P = 0.019), and low RILPL2 expression indicated higher stage.

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PMC7759933

However, in larger spheroids, small patches of death cells started to occur approximately on day 4 and by day 6, reached 16.5% dead cells on average with the visible formation of a necrotic core.

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PMC11092382

Detectable levels in the brain and adipose tissues suggested penetration of the blood‒brain barrier (Liu and Huang, 1988).

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PMC3888431

If more than one ORF of a transcript had a significant hit, the hit with the highest score was chosen.

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PMC11473750

However, knocking down RNF121 did not result in reduced MYCN mRNA expression levels (Fig. 5c), suggesting that the interaction between MYCN and RNF121 was post-translation.

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PMC11792766

The investigation emphasizes conventional bioassays used to evaluate cytotoxic potency on HepG2 and Caco‐2 cell lines, which are commonly employed for assessing hepatotoxicity and colon toxicity.

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PMC11727062

Artemisinin, a sesquiterpene lactone with diverse pharmacological properties, perturbs mitochondrial homeostasis in neoplastic cells and modulates the secretion and functionality of angiogenic factors via autocrine and paracrine signaling pathways, thereby inhibiting tumor-associated angiogenesis and preventing the epi...

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PMC11098378

Data are means ± SD; n = 3.

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PMC5716223

2Effects of NGF supplementation on L6C5 in vitro differentiation.

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PMC9164404

D Tumor growth inhibition curves of mice treated with PBS, cisplatin, and Abplatin.

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PMC10522430

Following this, a thrice-repeated washing step was undertaken using a washing buffer.

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PMC9429973

We compared Ly subsets before and after the completion of the two doses of vaccination schedule: interestingly, after the second dose, R exhibited significantly higher total Ly counts, CD3+, CD4+ and CD19+ (Fig.1I).

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PMC11638255

Data presented as mean ± SEM, n = 3 (Saline + IgG2a); n = 4, (Saline + anti-GD2, TETA + anti-GD2), n = 5 (TETA + IgG2a) biological replicates with three technical replicates, one independent experiment.

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PMC8956657

no significance; ****p < 0.0001.

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PMC10993311

The 17 cellular components identified by functional annotation of the DMRs can be found in Table S3.

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PMC10006224

Previous results in yeast had shown that cohesin could be detected at loading sites in scc2 mutants by chromatin immunoprecipitation.

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PMC11075223

−)-syringaresinol (274), (+)-isolarisiresinol 3-O-β-D-glucoside (275), syringaresinol di-O-β-D-allopyranoside (276) belong to dibenzylbutane, arylnaphthalene, dibenzyltyrolactone, respectively .

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PMC10944868

In the case of our tested compounds, it should be noted that all derivatives present the necessary conditions to be PGP-substrate candidates (Figure 4).

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PMC9065483

The experiment was conducted in triplicate.

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PMC10440586

But this inclination was not reflected by post-dosing CD99 expression (Supplementary Figure 5 G).

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PMC8526701

Noncancer cell lines HEK293 and NCM356 cells were highly resistant to BRD9 inhibition (Fig. S1A and B).

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PMC8839885

Briefly, human OC cell lines A2780 and A2780CisR were plated at 8 × 10 cells/cm in 25 cm or 75 cm cell-culture flasks and incubated in culture medium.

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PMC11283030

Secondly, the shortcoming is the lack of direct interaction through flow cytometry or immunoprecipitation (IP) of ACLY with immune cells or immune inhibitors in vitro.

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PMC10545062

After a laparotomy and cystostomy tube placement, a splenectomy was performed to minimize hemodynamic variation from autotransfusion.

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PMC11402217

Scale bars = 10 μM. Western blotting results (I) and the normalized quantitative results (J) of overexpression Dkk1 transfected 143B cells.

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PMC8973085

White solid [A] (90%), [B] (65%); mp: 201–204 °C (EtOH); IR (KBr, v, cm): 3240 (NH), 2221 (CN), 1747 (C=O), 1636 (C=O); H NMR (DMSO-d6): δ 1.26 (t, 3H, CH3), 2.55 (s, 3H, CH3), 3.70 (s, 3H, OCH3), 3.74 (s, 3H, OCH3), 4.17 (s, 2H, CH2), 4.19 (q, 2H, CH2), 6.95–7.46 (m, 7H, CH-Ar), 10.52 (bs, 1H, NH); C NMR (DMSO-d6): δ ...

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PMC8956657

Here, by using a combination of structural, biophysical, and cellular data, we have examined the ORF4b interaction with different IMPα isoforms.

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PMC10882807

Patients who received surgical treatment without any other treatment were chosen for the study.

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PMC11772449

At the same time, the gray value of WB results was statistically analyzed by ImageJ software.

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PMC9429973

Image: Summary/Conclusion: Our data indicate that mitapivat was at least as effective as splenectomy in treatment of anemia in a murine model of HS.

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PMC11095939

Co-IP using Mecp2 antibody revealed that Mecp2-associated ubiquitin and Nedd4 were dramatically increased at 3 hr and 6 hr post-SR (Figure 5B), suggesting that Nedd4 interacts with Mecp2 to induce the polyubiquitination and degradation of Mecp2 upon cell cycle reentry. (

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PMC9429973

Accordingly, after their deletion, the ability of c-Fos to recognize the promoter was overcome.

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PMC11673902

With the application of high-speed imaging or electrical impedance measurement, a higher throughput can be achieved compared to most other deformability measurement methods.

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PMC8873393

D Heat-map diagram showing the six clusters of differentially expressed transcripts in the chromatin extract following UV exposure.

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PMC11467800

These interactions result in the emergence of distinct cellular adaptive states, which subsequently influence tumour growth, invasion, metastasis and response to therapy. , , ,

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PMC11365427

ATF3 regulates CHOP expression either directly or indirectly, and CHOP, in turn, can regulate ATF3 expression.

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PMC11351758

The mitochondria have complexes, identified as I, II, III, IV, and V, and any anomaly to these complexes also leads to reactive oxygen species production.

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PMC11607764

For example, Qian et al showed that mouse astrocytes were converted to functional dopaminergic neurons by depleting the RNA binding protein PTBP1, and then Parkinson’s disease-relevant motor phenotypes were reversed.

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PMC11401358

Statistical analysis of ROS levels and inflammatory cells in G. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)Fig.

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PMC11093197

Cells were analyzed by FACSCanto Flow Cytometer.

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PMC10024132

p < 0.05, **p < 0.01.Fig 3 Blinatumomab DNA-transduced γ9δ2 T cells exert robust in vitro anti-tumor activity against CD19-expressing tumor cells. (

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PMC5417661

Addition of VEGF (20 ng/mL +0.1% DMSO) increased the peak mean cord length to 8.7±0.5 mm/mm and peak mean branch point to 47.6±4.4 mm/mm (Figures S2 and 4A).

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PMC10933092

Newly diagnosed cases present with non-muscle-invasive bladder cancer (NMIBC), which is usually treated by transurethral resection and intravesical therapy.

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PMC11742670

From this DRY LAB phase, the selected compounds were examined against the same cancer cell lines.

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PMC11420784

NDP52, which contains an LC3-interacting motif and a ubiquitin-binding domain, recruits the autophagy machinery to create a phagophore surrounding intracellular bacteria .

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PMC11791432

Yanwen Chen: Writing – original draft, Funding acquisition, Formal analysis, Data curation, Conceptualization.

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PMC11756514

The present report demonstrates that langerin, MBL, and SP-D can bind to S. aureus, but MGL cannot.

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PMC11682172

Co-culturing experiments were repeated twice for proteomics and genomics measurements.

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PMC6222726

Compound 32 was already known as a synthetic derivative of podophyllotoxin but it was new as a natural product.

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PMC11774112

A bicinchoninic acid (BCA) assay kit was acquired from Pierce (Rockford, IL, USA).

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PMC11705630

Glycine decarboxylase (GLDC) is a mitochondrial enzyme that takes part in the oxidation of glycine to support nucleotide biosynthesis via transfer of one-carbon units.

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PMC3122064

In contrast, other studies have failed to support a role for p53 in TC responsiveness, although the involvement of the MDM2–p53 complex in the response to chemotherapy had not been thoroughly assessed.

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PMC11588008

Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance with the tenets of the Helsinki Declaration, and has been approved by the Institution Review Board, Tianjin Central Hospital of Obstetrics and Gynecology (No. 2020KY...

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PMC11705862

The disorder is neuropathologically characterized by the presence of senile plaques and neurofibrillary tangles (NFTs), where the former arise due to an accumulation of amyloid beta (Aβ) and the latter is a result of intra-neuronal accumulation of hyperphosphorylated tau (p-tau).

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PMC7171147

The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD016244.

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PMC10898159

Moreover, LIX1 can controls MAPK signaling pathway .

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PMC11300639

Being fixed with 4% paraformaldehyde for 15 min, the cells were subsequently incubated with anti-RNF26 (#16802-1-AP, Proteintech, 1:200 dilution) or anti-TSC1 (#29906-1-AP, Proteintech, 1:250 dilution) antibody at 4 °C overnight, and washed several times with PBS.

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PMC11377827

This USP43 association promotes HIF-1 accumulation in the nucleus, and is required for the efficiency of HIF-1 to HREs on chromatin to activate gene transcription.

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PMC9454852

Such a view is further corroborated by our finding of GRP78 expression at the cell surface, and in addition by the observed positive correlation between cell surface GRP78 levels and the degree of AKT phosphorylation .

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PMC9429973

The median day of apheresis was D+26 from the start to chemotherapy (range 22-39).

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PMC11694625

The results revealed that 3a–3d all had potential anticancer activity, while exhibiting no discernible effect on normal human liver cells HL-7702.

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PMC10898159

AMPD3, belonging to the adenosine monophosphate deaminases (AMPDs), functions as a main catalyzer which hydrolytically deaminates AMP to inosine monophosphate.

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PMC11201245

The relative 5-year survival rate is about 40%.

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PMC11621565

Between 1.25 and 80 µg/ml no decrease in MTS value was seen.

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PMC11365983

Only small numbers of transcription factors have been identified in vertebrates: including the Rfx gene family (Rfx1-4), and two Forkhead Box (FOX) family members (Foxj1 and Foxn4) that directly regulate development of motile cilia.

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PMC11435360

After 24 h in normal culture conditions, cells were subjected to 0, 8, or 36 h of hypoxia (5% CO2, 0.5% O2, 95% N2) at 37 °C using a HypOxystation H85 hypoxia chamber (HYPO2YGEN, Frederick, MD, USA).

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PMC9429973

M. Wobus, E. Balaian, M. Lissner, R. Towers, U. Oelschlägel, R. Wehner, T. Chavakis, M. Törngren, H. Eriksson, E. Bondesson, U. Platzbecker, M. Bornhäuser, K. Sockel Department of Medicine 1, University Hospital TU Dresden, Dresden; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Cente...

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PMC9429973

S. Kapustin, A. Chechulova, J. Drijun, S. Svitina, V. Burakov, V. Soroka, V. Soldatenkov, L. Papayan Russian Research Institute of Hematology and Tranfusiology, Saint-Petersburg; Dzhanelidze Research Institute of Emergency Medicine, Saint Petersburg; Dzhanelidze Research Institute of Emergency Medicine, Saint-Petersbur...

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