OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11531735	This dataset not only provides critical insights into the effectiveness of ER121 in preclinical models but also serves as a compelling rationale for further exploring its clinical utility, particularly in the context of ErbB-associated breast cancer metastasis, with a specific emphasis on the challenging landscape of t...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549062	Protein concentrations were determined using the BCA method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "concentrations", "were", "determined", "using", "the", "BCA", "method", "." ] } ]
PMC11694346	Upon activation by biothiols, the resulting probe BT-NH exhibited a maximum emission wavelength of 630 nm, with a significant Stokes shift of ≈200 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10047551	HCC827ER2 and HCC827ER3 have higher PD-L1 mRNA expression relative to parental HCC827 cells, whereas HCC827ER4 and HCC827ER10 have lower PD-L1 mRNA expression (Figure S2A) .	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC9847912	The resulting yield of infectious virus was determined by plating supernatants from the 293T/17 cultures onto MAGIC-5A indicator cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "The", "resulting", "y...
PMC11543853	c Endosomes full of rhinovirus 2 virions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Endosomes", "full", "of", "rhinovirus", "2", "virions", "." ] } ]
PMC8750422	Specific bands were detected using the WEST-ZOL plus Western Blot Detection System (iNtRON Biotechnology, Seongnam, Korea).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specific", "bands", "were", ...
PMC11604768	The TF-TRE mechanism has long been harnessed to create engineered systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TF-TRE", "mechanism", "has", "long", "been", "harnessed", "to", "create", "eng...
PMC10253973	As it was already mentioned, molecular docking studies are often supplementary to the experimental results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "it", "was", "already", "mentioned", ",", "...
PMC7759933	The increase in the average surface area was higher at the lower initial cell density, meaning that the cells proliferated at a higher rate compared to spheroids with higher initial density, which was also reported by Lee et al. (2009) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Lipid raft staining (G) via Alexa Fluor 488 conjugated cholera toxin subunit B (CTX-AF488) and analysis (H) of mean pixel intensity per cell (N = 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765879	In the SK-BR-3 cell line, the migration percentage was reduced to 34.2 ± 2.2% and 11.5 ± 0.9% at 40 and 60 µg/mL, respectively (Figure 12).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11361748	A comparative analysis was conducted between the expression level of TAR11 and level of KRT6A and KRT17 in each cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "comparative", "analysis...
PMC11796104	The clinical validation experiments suggest that some of the circRNAs in this ceRNA network are differentially expressed between osteoporosis patients and people with normal bone mass.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4839679	While the panel of genes differentially regulated in PBRM1-mutated tumors express a hypoxic signature, no clear definition of PBRM1-regulated genes has come from these analyses, most likely due to the high heterogeneity of ccRCC tumors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Despite this, phenylalanine-based nutritional deprivation therapy warrants further investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "this", ",", "phenylalanine-based", "nutritional", "deprivation", "therapy", "warrants", "fu...
PMC10747139	Finally, one of the major hindrances regarding the development of Ru(II) complexes and their application in clinics is that their mechanisms of action are still poorly investigated and understood, from which the need for in-depth studies is highly desirable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	Furthermore, there is a significant regional variation in the incidence rate of CP, which increases from the lowest in the south-western-most to highest in the north-eastern-most province of the country.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11400680	The architecture of SAM is comprised of three components: (i) image encoder (ii) prompt encoder and (iii) mask decoder.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11621493	In line with our observations, subsequent activity-based assays revealed that PLA2G4D exhibits both phospholipase A1 and A2 activity, but no strict FA and head group preferences (30, 31, 33).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637284	Proper BB duplication, maturation, segregation, and its positioning within the cell, ensures correct segregation of flagella, the replicated kDNAs and other structures during cytokinesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	The peak area of SIINFEKL was 1.5-fold higher in samples treated with tubastatin-A or ACY-738 compared with untreated counterparts (Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11536589	Continuous variables were compared with an unpaired student t-test between 2 groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Continuous", "variables", "were", "compared", "with", "an", "unpaired", "student", ...
PMC9429973	More importantly, some of the selected drugs improved RTX-mediated effector mechanisms such as ADCC and immunophagocytosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "importantly", ",", "some", "of", "t...
PMC11279397	Consequently, these viruses profoundly affect both the quality of life for patients as well as economic aspects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "these", "viruses", ...
PMC9777812	These results demonstrated the regulatory role of bta-miR-106b on CDKN1A expresion by targeting its 3′UTR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "demonstrated", "the", "regulatory", "role", ...
PMC9429973	At FEDR initiation, 88% of patients had palpable spleen; mean spleen size was 16.0 cm (standard deviation [SD] 5.8) above the costal margin, which decreased to 13.2 cm (SD 7.9) at 3 months (P=0.0001) and 7.2 cm (SD 7.4) at 6 months (P=0.012).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	no. A39240, Thermo Fisher Scientific) suspension cells were grown in Expi293 Expression Medium (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "A39240", ",", "Thermo", "Fisher", "S...
PMC8728081	Fig. 5 Morphology (right-sided images) and ROS (left-sided images) of Kajjali and Rasasindura treated zebrafish larvae (K100 = 100 ppm and, K1000 = 1000 ppm Kajjali: R100 = 100 ppm, R1000 = 1000 ppm Rasasindura).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Interestingly, patients carrying IGHV 3-21 were often characterized by low Ki-67 index (Ki-67 <30%: 86% vs 64% of other cases, p<0.01) and low risk MIPI score (73% vs 43%, p=0.001), while no case of blastoid morphology was registered among the IGHV 4-34 patients (vs 89%, p<0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Hypothesis-generating analyses were conducted for patient subgroups of number of extranodal sites (ENS) (0–1 vs ≥2) and elevated lactate dehydrogenase (LDH) (yes vs no) in matched cohorts of patients receiving tafa + LEN vs STP, pola-BR, R2, and CAR-T. The primary endpoint was OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	Such conclusion was further supported by the observation that overexpressing TRIB2 decreased labile iron at basal level and also the one induced by RSL3 and erastin in SK-Hep1 cells (Fig. 3F).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In particular, chronic infection and UC may promote the selection of the DNMT3A gene mutation associated with CH by the IFNγ signaling induced in the course of these disorders.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	Bands were visualized using Clarity Western ECL Substrate (Bio-Rad, cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bands", "were", "visualized", "using", "Clarity", "Western", "ECL", "Substrate", ...
PMC11721587	Here, we report that Hh induces Fu/Ulk3 phase separation to form biomolecular condensates that recruit Sufu and Ci/Gli2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "report", ...
PMC9429973	The median follow-up duration was 13 months (range, 0.8-79 months).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "follow-up", "duration", "was", "13", "mont...
PMC11562028	At the administered concentration of 90 μg mL of the Re-CDs, the colony generating capacity of the A498 cells decreased to ∼24.9% ± 6.4% (Fig. 3F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705630	GLDC is the enzyme that catalyzes the first and rate limiting step in glycine metabolism, the product of which is used for nucleotide synthesis via the tetrahydrofolate (THF) cycle of one carbon metabolism 22, 23.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10522430	The resulting supernatant was precipitated using absolute ethanol in a 1 : 3 ratio.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulting", "supernatant", "was", "precipitated", "using", "abs...
PMC11806106	Rappleye and colleagues developed a high-throughput engineering platform to create receptor sensors carrying a cpGFP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rappleye", "and", "colleagues", "developed", "a", "high-throughpu...
PMC10055960	Inhibitory effects of the acetate-containing complexes (3 and 4)—with IC50 values of 45.65 and 52.57 µM, respectively—were found to favor the methyl-substituted complex (3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5035325	Table 2 shows a moderate to strong staining of EGFR and weak to strong intensity to NeuGcGM3 in 3LL-D122 model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Table", "2", "shows...
PMC11633763	Research findings indicate that β‐catenin is involved in various cancers and is stabilised by DUB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "findings", "indicate", "that", "β‐catenin", "is", ...
PMC11585587	To elucidate the anti-proliferation mechanism of RA, MM cells treated with RA for 12 H were stained with propidium iodide (PI) to detect the cell cycle distribution by FCM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7812570	B Expression of GPI-m36.4 or GPI-FluIgG03 on the surface of transduced TZM-bl cells with or without PI-PLC treatment, which was detected by an anti-His tag antibody and analyzed by FACS analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	A suspension of 3 cells per mL was obtained by 1/100 serial dilution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "suspension", "of", "3", "cells", "per", "mL", "was", "obtained",...
PMC11295144	To investigate these differences further, we have also carried out immunolabeling experiments to characterize the degree of innervation of HEK293 cells expressing different subunit combinations (Figures 6A–D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC2614415	It has been previously shown that overexpression of Aurora-A can induce resistance to paclitaxel in a cell culture model .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "previously",...
PMC5854676	All growth media and supplements were purchased from Sigma-Aldrich.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "growth", "media", "and", "supplements", "were", "purchased", "from", "Sigma-Aldrich", "." ] } ...
PMC11731614	The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5417661	NOV202 (MW 413), synthesized at SP Process Development AB (Södertälje, Sweden), was used at a concentration range of 0.1 nM–10.0 µM depending on the assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11551844	The adhered cells were then treated with diluted concentrations—prepared using PBS (1×)—of each fraction and JC-2 in triplicates to obtain final concentrations of 25, 12.5, 6.3, 3.1, 1.6 and 0.8 μg mL. After 72 h of incubation, an MTT cell viability assay was performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11085211	Patients’ treatment first relies on imatinib as the first-line therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "’", "treatment", "first", "relies", "on", "imatinib", "as", "the", "first...
PMC11777207	BMDCs reconstituted with full-length CD80 BMDCs had elevated levels of migration compared to BMDCs expressing L107E, consistent with Y56-L107 extracellular interactions between PD-L1 and CD80 being important for DC migration (Fig. 5G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11564322	The c-SRC inhibitor I increased the AKT kinase expression by 18.79%, compared to the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "c-SRC", "inhibitor", "I", "increased", ...
PMC9429973	During the course of Covid19 infection, pneumonia was registered in 52pts (98%), bleeding in 2pts (4%) and thrombosis in 4pts (8%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	These are engineered to mimic the discrete and localized targeting of native TPPP to Golgi outposts in oligodendrocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "are", "engineered", "to", "mi...
PMC11657744	Data are presented as means ± SD from three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "means", "±", "SD", "from", "three", "independent", ...
PMC10154097	The nucleoplasm separation experiment was carried out to detect the subcellular localization of circSOX4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "nucleoplasm", "separation", "experiment", "was", "carried", "ou...
PMC9429973	Based on this data, we chose a methyltransferase responsible for specific modification on tRNAs for further analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "this", "data", ",", ...
PMC11628309	MPP+ inhibits mitochondrial complex I, leading to increased oxidative stress (Li et al., 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MPP+", "inhibits", "mitochondrial", "complex...
PMC11281366	Lentiviruses were produced via the transfection of this vector in combination with pSVCMV-VSV-G in HEK-293T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "Lentiviruses", "were", "produced", "v...
PMC11472569	In DDP-resistant SKOV3 cells and tumor tissues, miR-21-5p expression was upregulated, while PDHA1 levels were significantly decreased.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "DDP-resi...
PMC9429973	In NR arm, with the median follow-up 517 (7-513) days, one-year OS and DFS were 59.2% and 40%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11680982	A,B) Stable knockdown of HER2 in human HR/HER2-low breast cancer cells by lentiviral shRNAs (shHER2 #1 and shHER2 #2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11564322	8Protein expression in the MEG-A2 cell line.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "8Protein", "expression", "in", "the", "MEG-A2", "cell", "line", "." ] } ]
PMC11791264	Recently, SETD7-mediated methylation of ATG16L1, an autophagy-related (ATG) protein, has been shown to act as a new regulatory mechanism to govern the formation of autophagosome (17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10362265	Human AF: blue, human model: black, human crystal: red, 3f62: green, 4ekx: orange, 4eee-SS AB chains: purple, 4eee-SS CD chains: yellow, 4eee-SH AB chains: teal, 4eee-SH CD chains: pink.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301095	The patient showed gradual improvement, with reduced cerebral edema, stabilized circulation, resumption of autonomous breathing, equal and round pupils approximately 5 mm in diameter, restored light reflex, occasional involuntary movement in the right upper limb, flexor response upon right upper limb stimulation, and r...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11407042	Note: Recovered P. aeruginosa cells can be stored at 4°C for 1–3 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", ":", "Recovered", "P.", "aeruginosa", "cells", ...
PMC10165258	In the case of fundamental scientific studies, the format of anchored microfluidic droplets has already been shown to be well-adapted for performing single-cell measurements that are resolved in both space and time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782508	Furthermore, the maximum likelihood phylogenetic relationship between the translated sequence of azurin protein from strain 105 and other related strains available in the NCBI database is represented in Fig. 1c.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700247	To investigate the enhanced crosspresentation and CART-19 tumor infiltration achieved by the combination of RT and CART-19 cell therapy, we tested the impact of RT on the expression of critical cytokines responsible for crosspriming and immune cell trafficking within tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594641	Our studies included three human melanoma cell lines, with various Rab27A and Rab27B expression levels, as well as their proliferative/invasive potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", ...
PMC9429973	EASIX score was calculated using the formula: LDH (U/L) × Creatinine (mg/dL) / platelet count (10^9/L) and analyzed based on log2 transformed values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	Subsequently, a loading buffer was added to the supernatant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "a", "loading", "buffer", "was", "added", "to", "the", "supernatant", ...
PMC10094712	All experiments were carried out at a temperature of 28–30 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "carried", "out", "at", "a", "temperature", "of", ...
PMC11126803	Knocking down LncRNA-SERB and overexpressing ERβ in the 786-O cell line (right panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Knocking", "down", "LncRNA-SERB", "and", "overexpressing", ...
PMC7823217	Furthermore, the lack of adequate ECM to support and communicate with cancer cells can also impact on biological relevance of these in vitro systems .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	In addition, OGM offers the possibility to identify new aberrations which can serve as patient specific MRD markers especially in cases without a previously known MRD marker.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	219 (27.3%) had a MyD MF, including 140 (17.5%) PMF and 79 (9.8%) SMF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11544771	The primary antibodies included antibodies to γH2AX, cyclin D1, cyclin E, cyclin A, cyclin B1, CDK4, CDK6, CDK2, CDK1, Cdc25A, Cdc25B, Cdc25C, p27, p21, Rb, p-Rb (S807/811), p-Rb (S780), Bcl-2, Bcl-xL, Mcl-1, survivin, BAD, BAK, BAX, RIP, FasL, Fas/CD95, TRADD, FADD, TRAIL, TNFα, TNFR1, DR4, DR5, BrdU and β-actin (Sant...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11535726	Subsequently, Boonmee et al. (2012) introduced Kirschsteiniotheliaceae to accommodate Kirschsteiniothelia species, based on morphology and phylogenetic analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", ...
PMC11321678	All animal experiments were performed following the approved protocols of the Department of Laboratory Animal Science, ensuring ethical compliance, and animal welfare.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11481779	Afterwards, in the second phase, the learnt parameters of the convolutional layers are used for training the final model - in which the sequence of 1Mbp is taken, then transformed using convolutional layers trained in phase 1, and then another dilated convolutional layers were applied, and the final output was in form ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5035325	NeuGcGM3 ganglioside-positive section (red).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NeuGcGM3", "ganglioside-positive", "section", "(", "red", ")", "." ] } ]
PMC11283030	b. WB analysis to validate the efficiency of ACLY silencing in 786-O and A498 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "b.", "WB", "analysis", "to", "validate", "the",...
PMC6222635	The exact molecular weight of the dextran standard and the retention time in HPGPC were used for establishing a standard curve.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exact", "m...
PMC11307990	786-0 cells (1.5 × 10 in 1 mL of medium) were seeded in a 96-well plate and cultured overnight.	[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], ...
PMC9532503	The ADCC activity of the test anti-CD20 antibody (P2-CRD-1508) was measured in comparison to that of the control antibody (RS-03-25).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11248911	The QSAR study showed that the antiproliferative activity of this set of compounds are attributed to the molecular bulkiness and partial charge distribution and hence its impact on the molecular size as well as its ability to form electrostatic interactions as hydrogen-bond.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8303372	A contrasting result is instead given by the effect of the 200 µM in encapsulated form in comparison with the same dose in free form: the treatment with NPs did not hamper the steady increase of normalized resistance (similarly to the two controls), in continuation of the time course before treatment, whereas the free-...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10998613	FRET or BRET assays are widely used to study protein–protein interactions in living cells and are scalable for screening purposes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FRET", "or",...
PMC9429973	Thus, the first-in-human clinical study is ongoing, to test CD19 CAR-T cells with decreased HPK1 expression (XYF19 CAR-T cells) for adult (r/r) B-ALL (NCT04037566).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	We employed a GMP-compatible retroviral system commonly used for CAR-T cell manufacturing to transduce the constant region-murinized PTPRZ1-TCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "employed", "a", "GMP-compatible", ...
PMC9960565	Moreover, the Gibbs free energy of the binding process was also determined, and the negative values indicated a spontaneous process (Table 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Most frequently mutated genes were the epigenetic regulators KMT2D (n=23; 42.6%) and SETD1B (n=17; 31.5%), followed by FAS, PIM1 and RERE (n=15; 27.8%), TBL1XR1 (n=14; 26%), BCL11A (n=13; 24%) and SGK1 (n=12; 22%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	Furthermore, histopathological analysis revealed no noticeable tissue damage or pathological changes in the liver and kidneys (Supplementary Fig. 2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ...
PMC11412721	Tumor volumes upon dissection of Trp53 Eμ-Myc and Trp53 Eμ-Myc mice, classified according to sex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "volumes", "upon", "dissection", "of", "Trp53"...
PMC10969097	Currently, no participants are being recruited for this study; therefore, no results are available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "no", "participants", "are", ...

PMC11531735

This dataset not only provides critical insights into the effectiveness of ER121 in preclinical models but also serves as a compelling rationale for further exploring its clinical utility, particularly in the context of ErbB-associated breast cancer metastasis, with a specific emphasis on the challenging landscape of t...

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PMC11549062

Protein concentrations were determined using the BCA method.

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PMC11694346

Upon activation by biothiols, the resulting probe BT-NH exhibited a maximum emission wavelength of 630 nm, with a significant Stokes shift of ≈200 nm.

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PMC10047551

HCC827ER2 and HCC827ER3 have higher PD-L1 mRNA expression relative to parental HCC827 cells, whereas HCC827ER4 and HCC827ER10 have lower PD-L1 mRNA expression (Figure S2A) .

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PMC9847912

The resulting yield of infectious virus was determined by plating supernatants from the 293T/17 cultures onto MAGIC-5A indicator cells.

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PMC11543853

c Endosomes full of rhinovirus 2 virions.

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PMC8750422

Specific bands were detected using the WEST-ZOL plus Western Blot Detection System (iNtRON Biotechnology, Seongnam, Korea).

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PMC11604768

The TF-TRE mechanism has long been harnessed to create engineered systems.

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PMC10253973

As it was already mentioned, molecular docking studies are often supplementary to the experimental results.

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PMC7759933

The increase in the average surface area was higher at the lower initial cell density, meaning that the cells proliferated at a higher rate compared to spheroids with higher initial density, which was also reported by Lee et al. (2009) .

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PMC11754432

Lipid raft staining (G) via Alexa Fluor 488 conjugated cholera toxin subunit B (CTX-AF488) and analysis (H) of mean pixel intensity per cell (N = 6).

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PMC11765879

In the SK-BR-3 cell line, the migration percentage was reduced to 34.2 ± 2.2% and 11.5 ± 0.9% at 40 and 60 µg/mL, respectively (Figure 12).

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PMC11361748

A comparative analysis was conducted between the expression level of TAR11 and level of KRT6A and KRT17 in each cell.

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PMC11796104

The clinical validation experiments suggest that some of the circRNAs in this ceRNA network are differentially expressed between osteoporosis patients and people with normal bone mass.

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PMC4839679

While the panel of genes differentially regulated in PBRM1-mutated tumors express a hypoxic signature, no clear definition of PBRM1-regulated genes has come from these analyses, most likely due to the high heterogeneity of ccRCC tumors .

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PMC11365427

Despite this, phenylalanine-based nutritional deprivation therapy warrants further investigation.

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PMC10747139

Finally, one of the major hindrances regarding the development of Ru(II) complexes and their application in clinics is that their mechanisms of action are still poorly investigated and understood, from which the need for in-depth studies is highly desirable.

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PMC11538390

Furthermore, there is a significant regional variation in the incidence rate of CP, which increases from the lowest in the south-western-most to highest in the north-eastern-most province of the country.

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PMC11400680

The architecture of SAM is comprised of three components: (i) image encoder (ii) prompt encoder and (iii) mask decoder.

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PMC11621493

In line with our observations, subsequent activity-based assays revealed that PLA2G4D exhibits both phospholipase A1 and A2 activity, but no strict FA and head group preferences (30, 31, 33).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11637284

Proper BB duplication, maturation, segregation, and its positioning within the cell, ensures correct segregation of flagella, the replicated kDNAs and other structures during cytokinesis .

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PMC11188874

The peak area of SIINFEKL was 1.5-fold higher in samples treated with tubastatin-A or ACY-738 compared with untreated counterparts (Fig. 3B).

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PMC11536589

Continuous variables were compared with an unpaired student t-test between 2 groups.

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PMC9429973

More importantly, some of the selected drugs improved RTX-mediated effector mechanisms such as ADCC and immunophagocytosis.

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PMC11279397

Consequently, these viruses profoundly affect both the quality of life for patients as well as economic aspects.

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PMC9777812

These results demonstrated the regulatory role of bta-miR-106b on CDKN1A expresion by targeting its 3′UTR.

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PMC9429973

At FEDR initiation, 88% of patients had palpable spleen; mean spleen size was 16.0 cm (standard deviation [SD] 5.8) above the costal margin, which decreased to 13.2 cm (SD 7.9) at 3 months (P=0.0001) and 7.2 cm (SD 7.4) at 6 months (P=0.012).

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PMC10237474

no. A39240, Thermo Fisher Scientific) suspension cells were grown in Expi293 Expression Medium (cat.

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PMC8728081

Fig. 5 Morphology (right-sided images) and ROS (left-sided images) of Kajjali and Rasasindura treated zebrafish larvae (K100 = 100 ppm and, K1000 = 1000 ppm Kajjali: R100 = 100 ppm, R1000 = 1000 ppm Rasasindura).

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PMC9429973

Interestingly, patients carrying IGHV 3-21 were often characterized by low Ki-67 index (Ki-67 <30%: 86% vs 64% of other cases, p<0.01) and low risk MIPI score (73% vs 43%, p=0.001), while no case of blastoid morphology was registered among the IGHV 4-34 patients (vs 89%, p<0.05).

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PMC9429973

Hypothesis-generating analyses were conducted for patient subgroups of number of extranodal sites (ENS) (0–1 vs ≥2) and elevated lactate dehydrogenase (LDH) (yes vs no) in matched cohorts of patients receiving tafa + LEN vs STP, pola-BR, R2, and CAR-T. The primary endpoint was OS.

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PMC8316344

Such conclusion was further supported by the observation that overexpressing TRIB2 decreased labile iron at basal level and also the one induced by RSL3 and erastin in SK-Hep1 cells (Fig. 3F).Fig.

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PMC9429973

In particular, chronic infection and UC may promote the selection of the DNMT3A gene mutation associated with CH by the IFNγ signaling induced in the course of these disorders.

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PMC9065483

Bands were visualized using Clarity Western ECL Substrate (Bio-Rad, cat.

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PMC11721587

Here, we report that Hh induces Fu/Ulk3 phase separation to form biomolecular condensates that recruit Sufu and Ci/Gli2.

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PMC9429973

The median follow-up duration was 13 months (range, 0.8-79 months).

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PMC11562028

At the administered concentration of 90 μg mL of the Re-CDs, the colony generating capacity of the A498 cells decreased to ∼24.9% ± 6.4% (Fig. 3F).

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PMC11705630

GLDC is the enzyme that catalyzes the first and rate limiting step in glycine metabolism, the product of which is used for nucleotide synthesis via the tetrahydrofolate (THF) cycle of one carbon metabolism 22, 23.

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PMC10522430

The resulting supernatant was precipitated using absolute ethanol in a 1 : 3 ratio.

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PMC11806106

Rappleye and colleagues developed a high-throughput engineering platform to create receptor sensors carrying a cpGFP.

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PMC10055960

Inhibitory effects of the acetate-containing complexes (3 and 4)—with IC50 values of 45.65 and 52.57 µM, respectively—were found to favor the methyl-substituted complex (3).

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PMC5035325

Table 2 shows a moderate to strong staining of EGFR and weak to strong intensity to NeuGcGM3 in 3LL-D122 model.

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PMC11633763

Research findings indicate that β‐catenin is involved in various cancers and is stabilised by DUB.

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PMC11585587

To elucidate the anti-proliferation mechanism of RA, MM cells treated with RA for 12 H were stained with propidium iodide (PI) to detect the cell cycle distribution by FCM.

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PMC7812570

B Expression of GPI-m36.4 or GPI-FluIgG03 on the surface of transduced TZM-bl cells with or without PI-PLC treatment, which was detected by an anti-His tag antibody and analyzed by FACS analysis.

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PMC10114490

A suspension of 3 cells per mL was obtained by 1/100 serial dilution.

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PMC11295144

To investigate these differences further, we have also carried out immunolabeling experiments to characterize the degree of innervation of HEK293 cells expressing different subunit combinations (Figures 6A–D).

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PMC2614415

It has been previously shown that overexpression of Aurora-A can induce resistance to paclitaxel in a cell culture model .

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PMC5854676

All growth media and supplements were purchased from Sigma-Aldrich.

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PMC11731614

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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PMC5417661

NOV202 (MW 413), synthesized at SP Process Development AB (Södertälje, Sweden), was used at a concentration range of 0.1 nM–10.0 µM depending on the assay.

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PMC11551844

The adhered cells were then treated with diluted concentrations—prepared using PBS (1×)—of each fraction and JC-2 in triplicates to obtain final concentrations of 25, 12.5, 6.3, 3.1, 1.6 and 0.8 μg mL. After 72 h of incubation, an MTT cell viability assay was performed.

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PMC11085211

Patients’ treatment first relies on imatinib as the first-line therapy.

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PMC11777207

BMDCs reconstituted with full-length CD80 BMDCs had elevated levels of migration compared to BMDCs expressing L107E, consistent with Y56-L107 extracellular interactions between PD-L1 and CD80 being important for DC migration (Fig. 5G).

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PMC11564322

The c-SRC inhibitor I increased the AKT kinase expression by 18.79%, compared to the control.

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PMC9429973

During the course of Covid19 infection, pneumonia was registered in 52pts (98%), bleeding in 2pts (4%) and thrombosis in 4pts (8%).

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PMC11342785

These are engineered to mimic the discrete and localized targeting of native TPPP to Golgi outposts in oligodendrocytes.

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PMC11657744

Data are presented as means ± SD from three independent experiments.

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PMC10154097

The nucleoplasm separation experiment was carried out to detect the subcellular localization of circSOX4.

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PMC9429973

Based on this data, we chose a methyltransferase responsible for specific modification on tRNAs for further analysis.

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PMC11628309

MPP+ inhibits mitochondrial complex I, leading to increased oxidative stress (Li et al., 2024).

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PMC11281366

Lentiviruses were produced via the transfection of this vector in combination with pSVCMV-VSV-G in HEK-293T cells.

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PMC11472569

In DDP-resistant SKOV3 cells and tumor tissues, miR-21-5p expression was upregulated, while PDHA1 levels were significantly decreased.

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PMC9429973

In NR arm, with the median follow-up 517 (7-513) days, one-year OS and DFS were 59.2% and 40%.

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PMC11680982

A,B) Stable knockdown of HER2 in human HR/HER2-low breast cancer cells by lentiviral shRNAs (shHER2 #1 and shHER2 #2).

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PMC11564322

8Protein expression in the MEG-A2 cell line.

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PMC11791264

Recently, SETD7-mediated methylation of ATG16L1, an autophagy-related (ATG) protein, has been shown to act as a new regulatory mechanism to govern the formation of autophagosome (17).

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PMC10362265

Human AF: blue, human model: black, human crystal: red, 3f62: green, 4ekx: orange, 4eee-SS AB chains: purple, 4eee-SS CD chains: yellow, 4eee-SH AB chains: teal, 4eee-SH CD chains: pink.

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PMC11301095

The patient showed gradual improvement, with reduced cerebral edema, stabilized circulation, resumption of autonomous breathing, equal and round pupils approximately 5 mm in diameter, restored light reflex, occasional involuntary movement in the right upper limb, flexor response upon right upper limb stimulation, and r...

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PMC11407042

Note: Recovered P. aeruginosa cells can be stored at 4°C for 1–3 days.

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PMC10165258

In the case of fundamental scientific studies, the format of anchored microfluidic droplets has already been shown to be well-adapted for performing single-cell measurements that are resolved in both space and time.

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PMC11782508

Furthermore, the maximum likelihood phylogenetic relationship between the translated sequence of azurin protein from strain 105 and other related strains available in the NCBI database is represented in Fig. 1c.

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PMC11700247

To investigate the enhanced crosspresentation and CART-19 tumor infiltration achieved by the combination of RT and CART-19 cell therapy, we tested the impact of RT on the expression of critical cytokines responsible for crosspriming and immune cell trafficking within tumors.

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PMC11594641

Our studies included three human melanoma cell lines, with various Rab27A and Rab27B expression levels, as well as their proliferative/invasive potential.

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PMC9429973

EASIX score was calculated using the formula: LDH (U/L) × Creatinine (mg/dL) / platelet count (10^9/L) and analyzed based on log2 transformed values.

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PMC10994876

Subsequently, a loading buffer was added to the supernatant.

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PMC10094712

All experiments were carried out at a temperature of 28–30 °C.

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PMC11126803

Knocking down LncRNA-SERB and overexpressing ERβ in the 786-O cell line (right panel).

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PMC7823217

Furthermore, the lack of adequate ECM to support and communicate with cancer cells can also impact on biological relevance of these in vitro systems .

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PMC9429973

In addition, OGM offers the possibility to identify new aberrations which can serve as patient specific MRD markers especially in cases without a previously known MRD marker.

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PMC9429973

219 (27.3%) had a MyD MF, including 140 (17.5%) PMF and 79 (9.8%) SMF.

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PMC11544771

The primary antibodies included antibodies to γH2AX, cyclin D1, cyclin E, cyclin A, cyclin B1, CDK4, CDK6, CDK2, CDK1, Cdc25A, Cdc25B, Cdc25C, p27, p21, Rb, p-Rb (S807/811), p-Rb (S780), Bcl-2, Bcl-xL, Mcl-1, survivin, BAD, BAK, BAX, RIP, FasL, Fas/CD95, TRADD, FADD, TRAIL, TNFα, TNFR1, DR4, DR5, BrdU and β-actin (Sant...

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PMC11535726

Subsequently, Boonmee et al. (2012) introduced Kirschsteiniotheliaceae to accommodate Kirschsteiniothelia species, based on morphology and phylogenetic analyses.

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PMC11321678

All animal experiments were performed following the approved protocols of the Department of Laboratory Animal Science, ensuring ethical compliance, and animal welfare.

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PMC11481779

Afterwards, in the second phase, the learnt parameters of the convolutional layers are used for training the final model - in which the sequence of 1Mbp is taken, then transformed using convolutional layers trained in phase 1, and then another dilated convolutional layers were applied, and the final output was in form ...

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PMC5035325

NeuGcGM3 ganglioside-positive section (red).

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PMC11283030

b. WB analysis to validate the efficiency of ACLY silencing in 786-O and A498 cells.

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PMC6222635

The exact molecular weight of the dextran standard and the retention time in HPGPC were used for establishing a standard curve.

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PMC11307990

786-0 cells (1.5 × 10 in 1 mL of medium) were seeded in a 96-well plate and cultured overnight.

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PMC9532503

The ADCC activity of the test anti-CD20 antibody (P2-CRD-1508) was measured in comparison to that of the control antibody (RS-03-25).

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PMC11248911

The QSAR study showed that the antiproliferative activity of this set of compounds are attributed to the molecular bulkiness and partial charge distribution and hence its impact on the molecular size as well as its ability to form electrostatic interactions as hydrogen-bond.

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PMC8303372

A contrasting result is instead given by the effect of the 200 µM in encapsulated form in comparison with the same dose in free form: the treatment with NPs did not hamper the steady increase of normalized resistance (similarly to the two controls), in continuation of the time course before treatment, whereas the free-...

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PMC10998613

FRET or BRET assays are widely used to study protein–protein interactions in living cells and are scalable for screening purposes.

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PMC9429973

Thus, the first-in-human clinical study is ongoing, to test CD19 CAR-T cells with decreased HPK1 expression (XYF19 CAR-T cells) for adult (r/r) B-ALL (NCT04037566).

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PMC11787355

We employed a GMP-compatible retroviral system commonly used for CAR-T cell manufacturing to transduce the constant region-murinized PTPRZ1-TCR.

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PMC9960565

Moreover, the Gibbs free energy of the binding process was also determined, and the negative values indicated a spontaneous process (Table 7).

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PMC9429973

Most frequently mutated genes were the epigenetic regulators KMT2D (n=23; 42.6%) and SETD1B (n=17; 31.5%), followed by FAS, PIM1 and RERE (n=15; 27.8%), TBL1XR1 (n=14; 26%), BCL11A (n=13; 24%) and SGK1 (n=12; 22%).

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PMC11453018

Furthermore, histopathological analysis revealed no noticeable tissue damage or pathological changes in the liver and kidneys (Supplementary Fig. 2D).

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PMC11412721

Tumor volumes upon dissection of Trp53 Eμ-Myc and Trp53 Eμ-Myc mice, classified according to sex.

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PMC10969097

Currently, no participants are being recruited for this study; therefore, no results are available.

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