OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC5839394	After 24 h of incubation 20 µL of the Cell titer 96AQueous reagent was added to each well after three washes with phosphate buffer saline (PBS) and incubated for 1-4 h at 37 °C in a CO2 incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730000	In addition, this study evaluated the expression of the mammalian target of rapamycin (mTOR) protein in the Chinese hamster ovary cell line (CHO-K1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O"...
PMC9429973	Research ethics approval was obtained.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "ethics", "approval", "was", "obtained", "." ] } ]
PMC9429973	Treatment with L-gln resulted in clinically significant outcomes combined with significant improvement of the hemolysis parameters from baseline through 72 weeks suggesting sustained long-term efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11519583	In total, 1978 mice were used for this study (including mice used to generate transgenic and gene-edited mice, to explore optimal conditions for experiments, and to learn experimental techniques).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193046	Fig. 1 provides the molecular formulae of the most prominent drug-like pan-ABC transporter inhibitors known until today.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1", "provides", "the", "molecular", ...
PMC8777939	AGR2 could serve as a biomarker for the prognosis of metastasis and chemotherapeutic response in breast cancer , lung cancer , gastric cancer , esophageal squamous cell carcinoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757131	Valine is considered the second or third most limiting amino acid with the highest absolute absorption in the mammary gland tissue of sows during lactation (5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754291	Cells were lysed by adding the lysis buffer, followed by incubation on ice for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "lysed", "by", "adding", "t...
PMC10976516	In situ, intratumoral, OV therapy consists of adenovirus-mediated expression of herpes simplex virus thymidine kinase (ADV/HSVtk) plus valacyclovir therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11738017	Medscape, LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Medscape", ",", "LLC", "designate...
PMC11789597	All studies that involved human samples were approved by the Ethical Committee for Clinical Medicine Research of The Third Affiliated Hospital of Sun Yat‐Sen University (02‐379) and the Medical Ethic Committee of Guangzhou Medical University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11471176	The evaluation of ACE2 inhibition was performed across a concentration range of 12.5–100 mg/ml (equivalent to ∼ 55.2–442 mM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "evaluation", ...
PMC11467964	At the same time, functional enrichment analyses were carried out based on above BM cluster‐related DEGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "same", "time", ",", "functiona...
PMC9429973	After a median follow-up of 28 months, median PFS was 10.4 months, median OS was not reached (OS after 24 months until 39 months plateau 0.504).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No patient suffered primary graft failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "patient", "suffered", "primary", "graft", "failure", "." ] } ]
PMC11476106	Specifically, cell line A673 (Figure 5, top graphs) showed no remarkable differences in any size category with respect to VN cross-linking in the scaffolds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	Based on the analysis of the EVs obtained, it was confirmed that the isolation was successful and that the exosomes constitute a population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6364197	In recent years, the research and development of targeted drugs has become a hot spot (28,29).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", ...
PMC11637716	Abdominal ultrasound did not show specific changes apart from splenomegaly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Abdominal", "ultrasound", "did", "not", "show", "specific", "changes", "apart", "from", "splenom...
PMC11337594	A transcriptome sequencing and metabolomic analysis of TER-treated A375 cells was conducted to identify potential pathways of action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "transcriptome", "sequencing", ...
PMC11798926	We used IFITM3 as a positive control for interaction with μ2 and surveyed multiple μAP subunits, including μ1a, μ2, μ3a and μ4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11240571	Background: Exosomal PD-L1 has garnered attention owing to its role in instigating systemic immune suppression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Background", ":", "Exosomal", "PD-L1", "has", "garnere...
PMC11321678	Third, the number of Tn5 insertions in the tile was summed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Third", ",", "the", "number", "of", "Tn5", "insertions", "in", "the", "til...
PMC11802929	We identify several viral antigen-specific T cell populations observed in previous work by ourselves and others demonstrating the feasibility of this framework on a whole viral proteome scale.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10006224	Images were analyzed with a custom made software programed in Definiens Developer XD v2.5 software (Definiens).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "analyzed", "with", "...
PMC11787355	d–f were analyzed with two-way ANOVA multiple comparison corrected with Holm–Šidák method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "–", "f", "were", "analyzed", "with", "two-w...
PMC11798926	Representative images and quantification of colocalization of SynDIG1 mutants with Golgin-97 and EEA1. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "and", "quantification", "of", "colocalization", ...
PMC9429973	B. Chin-Yee, P. Bhai, I. Cheong, M. Matyashin, C. Hsia, E. Kawata, J. Ho, M. Levy, A. Stuart, H. Lin, I. Chin-Yee, M. Kadour, B. Sadikovic, A. Lazo-Langner Hematology; Pathology and Laboratory Medicine, Western University, London, Canada; Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan B...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11407042	Besides, accurate calculation of both numbers of the A549 cells and P. aeruginosa cells prior to their co-culture are essential to establish an accurate MOI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11535726	N/A: data not available; A: data available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "N/A", ":", "data", "not", "available", ";", "A", ":", "data", "available", "." ] } ]
PMC11129910	Studies have reported that the dysregulation of RAB25 gene expression could be associated with the aggressiveness of various human cancers, including breast and ovarian cancers , prostate cancer , bladder carcinoma , lung cancer , bladder cancer , gastric carcinoma , head and neck cancer , and esophageal carcinoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11201245	They do not show any TP53 mutations and are characterized by their genetically relatively stable and indolent character .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "do", "not", "show", "any", ...
PMC9583612	It is hence paramount to effectively estimate the duration and frequency of such intermittent emissions, which requires the use of a high sampling frequency measurement system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11321678	QuantStudio 6 Real‐Time PCR system (Applied Biosystems, Foster City, CA, USA) and SYBR Green qPCR Master Mix (Vazyme Biotech, Nanjing, China) were used to perform qPCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	Maximal respiration was determined after FCCP injection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Maximal", "respiration", "was", "determined", "after", "FCCP", "injection", "." ] } ]
PMC9429973	Baseline characteristics, a history of cancer, time between breast cancer (due to possible breast reconstruction with an implant following cancer surgery) and BIA-ALCL, treatment modality, best response to treatment and survival outcomes were collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8873393	The known noncoding RNAs expressed in at least one fraction were identified by blasting the transcripts against the NONCODE v6.0 database using the following selection criteria: identity >0.9, coverage >0.8, and E value < 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	Recovery of P21 was also accompanied by recovery of apoptotic maker, BAX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recovery", "of", "P21", "was", "also", "accompanied", "by", "recovery", ...
PMC11653533	Anika Zaman: Visualization, Methodology, Formal analysis, Data curation, Conceptualization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anika", "Zaman", ":", "Visualization", ",", "Methodology", ",", ...
PMC9429973	Average adverse outcome rates based on study-level HbF averages were investigated in 735 analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Average", "adverse", "outcome", "rates", "based", "on", "study-level",...
PMC11683240	α1AT, α1-antitrypsin; PT, pertussis toxin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "α1AT", ",", "α1-antitrypsin", ";", "PT", ",", "pertussis", "toxin", "." ] } ]
PMC11361748	Rescue assays involving expression of EGFP-WTK17 and EGFP-WTK14 fusion proteins in KRT17 KO A431 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Rescue", "assays", "involving", "expression", "of", "EGF...
PMC11770199	Activation marker MHC-II expression in macrophages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "marker", "MHC-II", "expression", "in", "macrophages", "." ] } ]
PMC11045125	The EBV Akata-BX1 Burkitt lymphoma cell line was a gift from Lindsay Hutt-Fletcher and was obtained by super-infecting an EBV-negative clone of Akata Burkitt lymphoma cells with recombinant Akata EBV containing a G418 resistance gene cassette and GFP gene inserted into the EBV BXLF1 gene as previously described) .	[ { "tags": [ "O", "O", "B-CellLine", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11013014	Molecular docking simulations were performed using Autodock Vina software (ADT) MGLTools 1.5.6 packages, and the resulting data were analysed using Discovery Studio 2016 Client software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	All 22 pts experienced ≥1 TEAE; 12 (54.5%) pts experienced ≥1 TESAE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "22", "pts", "experienced", "≥1", "TEAE", ...
PMC11607764	The GEPIA2 database, which includes TCGA and GTEx data, was used to assess the top 100 genes highly correlated with PTBP1 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10840195	Finally, flow cytometry analysis was performed to calculate the apoptosis rates of cells in each group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "flow", "cytometry", "analysis", ...
PMC9429973	All patients were recommended to receive 6 cycles of ZR-CHOP (R-CHOP or R-CHOP were allowed in cycle 1 due to poor physical condition or inaccessible molecular characteristics at treatment) and patients older than 70 years old were administered ZR-miniCHOP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10490530	We combined FLuc2, NLuc, and hLuz in this new assay format to unravel any unknown regulatory insights by simultaneously monitoring the complex gene regulation in epithelial ovarian cancer (EOC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11569208	All statistical analyses and visualization of data was performed using Prism 9 (GraphPad, San Diego, CA) software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "statistical", ...
PMC9429973	Because diversity of LSR junctions in LSR-High CLLs is evocative of an on-going process, we analyzed the expression of productive and non-productive transcripts of the constant part of IgH locus, which we found increased in LSR-High when compared to LSR-Low CLLs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	Host cells contain a mutation plasmid (MP), described below, and gIII expression plasmids called the accessory plasmid (AP) and complementary plasmid (CP) to enable selection for integrases with improved activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10858941	Images were obtained using an inverted Olympus IX70 microscope equipped with epifluorescence optics and camera (Olympus OM-4 Ti) and, in the case of microdevices, Nikon Eclipse Ti-E coupled to a C1 modular confocal microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, prolonged parenteral PI therapy (e.g. with V) can be challenging to achieve in routine clinical practice, and outcomes for pts are often poorer in this setting compared with clinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11575040	Functional analysis revealed that silencing-LINC00094 inhibited the proliferation, colony formation, invasion, and migration of melanoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "analysis", "revealed", ...
PMC11462673	Unfortunately, the outcomes for relapsed T-ALL remain poor, with a 5-year OS of 35% .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "the", "outcomes", "for", ...
PMC11768927	For example, Jenks et al. demonstrated that VSV expressing human IFN-β (VSV-hIFNβ) showed no neurotoxicity in rodent and non-human primate models of hepatocellular carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784	To experimentally investigate the computing performance of DNP2, we labeled a Cy5 on sgc4f, a TAMRA on sgc8c and a FAM on Nb-S and labeled corresponding quenchers on complementary strands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10877303	Fig. 7 (b) indicates that the CID-14335962 (3-beta-O-(trans-p-Coumaroyl) maslinic acid)-3CL complex had extensions in the surface upon the binding of the ligand molecules, whereas the other two complexes had a stable SASA profile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Treatment-emergent SAEs of interest occurred in 4 (18%) patients, specifically: catheter site hemorrhage, gastrointestinal hemorrhage, coagulopathy, and hypotension, each occurring in 1 patient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	This type of analysis shows enrichments of TFs with the highest z-score in each of our different experimental conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "type", "of", "analysis", ...
PMC7602170	It is well established that the rate-limiting step is the initiation phase regulated by eukaryotic translation initiation factors (eIFs) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "well"...
PMC9918897	Since they were identical species, no inclusion or exclusion criteria were set up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "they", "were", "identical", "species", ",", "no", "incl...
PMC11706491	In fission yeast, early studies of cell cycle progression relied on observations of cell size.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "fission", "yeast", ",", "early", "studies", ...
PMC3888431	The venn diagram (b) shows the gene clusters created with the wcd tool.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "venn", "diagram", "(", "b", ")", "shows", "the...
PMC9895440	Likewise, the low abundance and unknown antigen specificity in TILs freshly obtained from patients hinder more comprehensive mechanistic studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Likewise", ",", "the", ...
PMC11720808	TRAF6 is an effector of TLR4, and Lin et al previously reported that lipopolysaccharide (LPS) can affect the interaction of TLR4 and TRAF6.28 Considering that SCU binds to TLR4 directly, we hypothesized that SCU may intervene in the interaction between TLR4 and TRAF6, resulting in the inactivation of the NF-κB signalin...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	II: Expression of MGMT (Methylated-DNA–protein-cysteine methyltransferase) DNA repair enzyme in OC236, sorted by EpCAM expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "II", ":", ...
PMC6267596	RNA Samples were assessed for quality with an Advanced Analytics Fragment Analyzer (High Sensitivity RNA Analysis Kit – Catalog # DNF-491 / User Guide DNF-491-2014AUG13) and quantity with a Qubit RNA quantification kit (Qubit® RNA HS Assay KitAssay Kit – Catalog # Q32852).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11769516	They also indicate a reduction in the number of genes for neurotrophic factors such as TH, BDNF and AADC, which makes DON-induced cell death associated with the impaired regulation of neurotransmitter release and reduced neuronal function .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9027909	From these subtypes, subtype (ST) 3 thought to be the most prevalent subtypes with wide distribution all over the world .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", ...
PMC11699465	IFNGR1 acts as a key factor in regulating demethylase JMJD2D-induced PD-L1 expression in colorectal cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IFNGR1", "acts", "as", "a", "key", "factor", "in", "r...
PMC11697065	We therefore characterized the clonal lines with respect to transgene copy number, mRNA transcript abundance, and protein expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "therefore", "character...
PMC9429973	Siltuximab—a monoclonal antibody against interleukin-6—is the only FDA- and EMA-approved treatment for iMCD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Siltuximab", "—", "a", "monoclonal", "antibody", "against", ...
PMC8753818	:> 0.05, :> 0.01, :> 0.001, ***:> 0.0001) Growth dynamics and cell viability: a Comparison of cell viability between CHO-K1 and CHO-KO cells during 24, 48 and 96 h. b Comparison of cell counting between CHO-K1and CHO-KO cells during 24, 48, 72 and 96 h. Results represent the average of three analyses (n = 5), and...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470381	The choice of method depends on various parameters, including image quality, signal strength, and background noise level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "choice", "of", ...
PMC9429973	Results: A total of 26 pts were enrolled and treated; median (range) age was 65.0 (44–80) years, 25 (96.2%) had ECOG PS ≤1, 11 (42.3%) had ≥2 prior systemic therapies, and 6 (23.1%) had received prior bendamustine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753435	The dissociation constant (KD) for the purified uAbs to β-catenin was measured by BLI assays using an Octet RH16 instrument (Sartorius) at 30°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10033453	∗p < 0.05, ∗∗∗∗p < 0.0001. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "<", "0.05", ",", "∗∗∗∗p", "<", "0.0001", ".", "(" ] } ]
PMC10734950	Densitometry was obtained using the Thermo Fisher iBright Densitometry analysis software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Densitometry", "was", "obtained", "using", "the", "Thermo", "Fisher", "iBright", "Densitome...
PMC11791432	1 × 10 cells per well were seeded in 96-well plates then cultured for 48 h in an incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "×", "10", "cells", "pe...
PMC11704135	The plates were examined to observe any color changes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plates", "were", "examined", "to", "observe", "any", "color", "changes", "." ] } ]
PMC6803987	As shown in Figure 2, after the sample was applied to the cells, the sample was able to improve cell growth and improve survival rate compared with the negative control group (* p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653168	Total STAT3 expression remained constant, similar to in CCRF-CEM cells (Fig. 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "STAT3", "expression", "remained", "constant", "...
PMC11470381	Live-cell imaging without CO2 supplementation and adequate humidification should be limited to shorter durations of no more than 30–40 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Live-cell", "imaging", "with...
PMC10213179	Various solid tumors, such as ovary, prostate, pancreas, glioblastoma, lung, melanoma, esophageal, colorectal, bone sarcomas, and breast, are reported to express high levels of the tyrosine kinase receptor EphA2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6160470	A2780 and A2780/Adr cells were cultured for 72 h without treatment (CTRL) or treated with verapamil (10 μM,) or DAC-2Amide and DAC-3Amide (2 μM).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC6600592	Preparation of Cyclohexyl 4-(4-substituted phenyl) -4-oxobutanoates (3) Compound 2 (2A, 2B, 2C, 2D, 15 mmol) reacted with cyclohexanol (30 mmol) in CH2Cl2 (20 mL) with p-methylbenzenesulfonic acid (TsOH) (2g, 11.6 mmol) under refluxing for 4 h (Scheme 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11412721	Gene set enrichment analysis (GSEA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "set", "enrichment", "analysis", "(", "GSEA", ")", "." ] } ]
PMC11607321	1Cancer multi-omics integration with MOSA.a Cancer cell line multi-omic datasets across the 1523 cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1Cancer", "multi-omics", "integration", ...
PMC11127909	Then, the images were photographed by the Leica DMi8 and analyzed by ImageJ (version 1.8.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "images", "were", ...
PMC10728200	The detection indexes of ferroptosis include the changes in mitochondrial morphology and levels of lipid ROS, Fe, and GSH .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "detection", ...
PMC11766332	Recently, miRNAs have gained prominence as important regulators of glycome .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "miRNAs", "have", "gained", "prominence", "as", "important", "regulators", ...
PMC11412721	Right, below: the Trp53 allele only enables the synthesis of proteins with the ‘canonical’ α C-terminus. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ",", "bel...
PMC9895440	Briefly, transcript count data was analyzed in R 4.2.1 using edgeR_3.38.4, limma_3.52.2, org.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "transcript", "count", "data", "was", ...
PMC9429973	Most pts received conditioning with melphalan 200mg/m for both transplants (1: 100%, 2: 96.2%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "pts", "re...
PMC6650823	Upon formation of a ternary complex POI–PROTAC–E3 ligase, the POI is ubiquitinated and degraded by the proteasome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upon", "form...
PMC11621493	Selected gene set enrichment plots for “cytokine activity,” “chemokine activity” (GO mf), and “lipid catabolic process” (GO bp) are shown in Figure 9B–D. Here, multiple cytokines and chemokines (Ccl2, Ccl9, Cxcl1, Cxcl12, Cxcl2, Il1a, Il23a, Lif, Tnf) were significantly upregulated, indicating increased inflammation in...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5839394

After 24 h of incubation 20 µL of the Cell titer 96AQueous reagent was added to each well after three washes with phosphate buffer saline (PBS) and incubated for 1-4 h at 37 °C in a CO2 incubator.

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PMC11730000

In addition, this study evaluated the expression of the mammalian target of rapamycin (mTOR) protein in the Chinese hamster ovary cell line (CHO-K1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O"...

PMC9429973

Research ethics approval was obtained.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "ethics", "approval", "was", "obtained", "." ] } ]

PMC9429973

Treatment with L-gln resulted in clinically significant outcomes combined with significant improvement of the hemolysis parameters from baseline through 72 weeks suggesting sustained long-term efficacy.

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PMC11519583

In total, 1978 mice were used for this study (including mice used to generate transgenic and gene-edited mice, to explore optimal conditions for experiments, and to learn experimental techniques).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8193046

Fig. 1 provides the molecular formulae of the most prominent drug-like pan-ABC transporter inhibitors known until today.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1", "provides", "the", "molecular", ...

PMC8777939

AGR2 could serve as a biomarker for the prognosis of metastasis and chemotherapeutic response in breast cancer , lung cancer , gastric cancer , esophageal squamous cell carcinoma .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11757131

Valine is considered the second or third most limiting amino acid with the highest absolute absorption in the mammary gland tissue of sows during lactation (5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11754291

Cells were lysed by adding the lysis buffer, followed by incubation on ice for 10 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "lysed", "by", "adding", "t...

PMC10976516

In situ, intratumoral, OV therapy consists of adenovirus-mediated expression of herpes simplex virus thymidine kinase (ADV/HSVtk) plus valacyclovir therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC11738017

Medscape, LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™.

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PMC11789597

All studies that involved human samples were approved by the Ethical Committee for Clinical Medicine Research of The Third Affiliated Hospital of Sun Yat‐Sen University (02‐379) and the Medical Ethic Committee of Guangzhou Medical University.

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PMC11471176

The evaluation of ACE2 inhibition was performed across a concentration range of 12.5–100 mg/ml (equivalent to ∼ 55.2–442 mM).

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PMC11467964

At the same time, functional enrichment analyses were carried out based on above BM cluster‐related DEGs.

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PMC9429973

After a median follow-up of 28 months, median PFS was 10.4 months, median OS was not reached (OS after 24 months until 39 months plateau 0.504).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

No patient suffered primary graft failure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "patient", "suffered", "primary", "graft", "failure", "." ] } ]

PMC11476106

Specifically, cell line A673 (Figure 5, top graphs) showed no remarkable differences in any size category with respect to VN cross-linking in the scaffolds.

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PMC11755519

Based on the analysis of the EVs obtained, it was confirmed that the isolation was successful and that the exosomes constitute a population.

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PMC6364197

In recent years, the research and development of targeted drugs has become a hot spot (28,29).

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PMC11637716

Abdominal ultrasound did not show specific changes apart from splenomegaly.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Abdominal", "ultrasound", "did", "not", "show", "specific", "changes", "apart", "from", "splenom...

PMC11337594

A transcriptome sequencing and metabolomic analysis of TER-treated A375 cells was conducted to identify potential pathways of action.

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PMC11798926

We used IFITM3 as a positive control for interaction with μ2 and surveyed multiple μAP subunits, including μ1a, μ2, μ3a and μ4.

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PMC11240571

Background: Exosomal PD-L1 has garnered attention owing to its role in instigating systemic immune suppression.

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PMC11321678

Third, the number of Tn5 insertions in the tile was summed.

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PMC11802929

We identify several viral antigen-specific T cell populations observed in previous work by ourselves and others demonstrating the feasibility of this framework on a whole viral proteome scale.

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PMC10006224

Images were analyzed with a custom made software programed in Definiens Developer XD v2.5 software (Definiens).

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PMC11787355

d–f were analyzed with two-way ANOVA multiple comparison corrected with Holm–Šidák method.

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PMC11798926

Representative images and quantification of colocalization of SynDIG1 mutants with Golgin-97 and EEA1. (

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PMC9429973

B. Chin-Yee, P. Bhai, I. Cheong, M. Matyashin, C. Hsia, E. Kawata, J. Ho, M. Levy, A. Stuart, H. Lin, I. Chin-Yee, M. Kadour, B. Sadikovic, A. Lazo-Langner Hematology; Pathology and Laboratory Medicine, Western University, London, Canada; Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan B...

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PMC11407042

Besides, accurate calculation of both numbers of the A549 cells and P. aeruginosa cells prior to their co-culture are essential to establish an accurate MOI.

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PMC11535726

N/A: data not available; A: data available.

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PMC11129910

Studies have reported that the dysregulation of RAB25 gene expression could be associated with the aggressiveness of various human cancers, including breast and ovarian cancers , prostate cancer , bladder carcinoma , lung cancer , bladder cancer , gastric carcinoma , head and neck cancer , and esophageal carcinoma .

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PMC11201245

They do not show any TP53 mutations and are characterized by their genetically relatively stable and indolent character .

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PMC9583612

It is hence paramount to effectively estimate the duration and frequency of such intermittent emissions, which requires the use of a high sampling frequency measurement system.

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PMC11321678

QuantStudio 6 Real‐Time PCR system (Applied Biosystems, Foster City, CA, USA) and SYBR Green qPCR Master Mix (Vazyme Biotech, Nanjing, China) were used to perform qPCR.

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PMC11632064

Maximal respiration was determined after FCCP injection.

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PMC9429973

Baseline characteristics, a history of cancer, time between breast cancer (due to possible breast reconstruction with an implant following cancer surgery) and BIA-ALCL, treatment modality, best response to treatment and survival outcomes were collected.

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PMC8873393

The known noncoding RNAs expressed in at least one fraction were identified by blasting the transcripts against the NONCODE v6.0 database using the following selection criteria: identity >0.9, coverage >0.8, and E value < 10.

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PMC11409031

Recovery of P21 was also accompanied by recovery of apoptotic maker, BAX.

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PMC11653533

Anika Zaman: Visualization, Methodology, Formal analysis, Data curation, Conceptualization.

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PMC9429973

Average adverse outcome rates based on study-level HbF averages were investigated in 735 analyses.

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PMC11683240

α1AT, α1-antitrypsin; PT, pertussis toxin.

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PMC11361748

Rescue assays involving expression of EGFP-WTK17 and EGFP-WTK14 fusion proteins in KRT17 KO A431 cells.

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PMC11770199

Activation marker MHC-II expression in macrophages.

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PMC11045125

The EBV Akata-BX1 Burkitt lymphoma cell line was a gift from Lindsay Hutt-Fletcher and was obtained by super-infecting an EBV-negative clone of Akata Burkitt lymphoma cells with recombinant Akata EBV containing a G418 resistance gene cassette and GFP gene inserted into the EBV BXLF1 gene as previously described) .

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PMC11013014

Molecular docking simulations were performed using Autodock Vina software (ADT) MGLTools 1.5.6 packages, and the resulting data were analysed using Discovery Studio 2016 Client software.

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PMC9429973

All 22 pts experienced ≥1 TEAE; 12 (54.5%) pts experienced ≥1 TESAE.

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PMC11607764

The GEPIA2 database, which includes TCGA and GTEx data, was used to assess the top 100 genes highly correlated with PTBP1 expression.

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PMC10840195

Finally, flow cytometry analysis was performed to calculate the apoptosis rates of cells in each group.

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PMC9429973

All patients were recommended to receive 6 cycles of ZR-CHOP (R-CHOP or R-CHOP were allowed in cycle 1 due to poor physical condition or inaccessible molecular characteristics at treatment) and patients older than 70 years old were administered ZR-miniCHOP.

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PMC10490530

We combined FLuc2, NLuc, and hLuz in this new assay format to unravel any unknown regulatory insights by simultaneously monitoring the complex gene regulation in epithelial ovarian cancer (EOC).

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PMC11569208

All statistical analyses and visualization of data was performed using Prism 9 (GraphPad, San Diego, CA) software.

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PMC9429973

Because diversity of LSR junctions in LSR-High CLLs is evocative of an on-going process, we analyzed the expression of productive and non-productive transcripts of the constant part of IgH locus, which we found increased in LSR-High when compared to LSR-Low CLLs.

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PMC11317131

Host cells contain a mutation plasmid (MP), described below, and gIII expression plasmids called the accessory plasmid (AP) and complementary plasmid (CP) to enable selection for integrases with improved activity.

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PMC10858941

Images were obtained using an inverted Olympus IX70 microscope equipped with epifluorescence optics and camera (Olympus OM-4 Ti) and, in the case of microdevices, Nikon Eclipse Ti-E coupled to a C1 modular confocal microscope.

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PMC9429973

However, prolonged parenteral PI therapy (e.g. with V) can be challenging to achieve in routine clinical practice, and outcomes for pts are often poorer in this setting compared with clinical trials.

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PMC11575040

Functional analysis revealed that silencing-LINC00094 inhibited the proliferation, colony formation, invasion, and migration of melanoma cells.

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PMC11462673

Unfortunately, the outcomes for relapsed T-ALL remain poor, with a 5-year OS of 35% .

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PMC11768927

For example, Jenks et al. demonstrated that VSV expressing human IFN-β (VSV-hIFNβ) showed no neurotoxicity in rodent and non-human primate models of hepatocellular carcinoma.

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PMC11754784

To experimentally investigate the computing performance of DNP2, we labeled a Cy5 on sgc4f, a TAMRA on sgc8c and a FAM on Nb-S and labeled corresponding quenchers on complementary strands.

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PMC10877303

Fig. 7 (b) indicates that the CID-14335962 (3-beta-O-(trans-p-Coumaroyl) maslinic acid)-3CL complex had extensions in the surface upon the binding of the ligand molecules, whereas the other two complexes had a stable SASA profile.

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PMC9429973

Treatment-emergent SAEs of interest occurred in 4 (18%) patients, specifically: catheter site hemorrhage, gastrointestinal hemorrhage, coagulopathy, and hypotension, each occurring in 1 patient.

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PMC11489351

This type of analysis shows enrichments of TFs with the highest z-score in each of our different experimental conditions.

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PMC7602170

It is well established that the rate-limiting step is the initiation phase regulated by eukaryotic translation initiation factors (eIFs) .

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PMC9918897

Since they were identical species, no inclusion or exclusion criteria were set up.

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PMC11706491

In fission yeast, early studies of cell cycle progression relied on observations of cell size.

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PMC3888431

The venn diagram (b) shows the gene clusters created with the wcd tool.

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PMC9895440

Likewise, the low abundance and unknown antigen specificity in TILs freshly obtained from patients hinder more comprehensive mechanistic studies.

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PMC11720808

TRAF6 is an effector of TLR4, and Lin et al previously reported that lipopolysaccharide (LPS) can affect the interaction of TLR4 and TRAF6.28 Considering that SCU binds to TLR4 directly, we hypothesized that SCU may intervene in the interaction between TLR4 and TRAF6, resulting in the inactivation of the NF-κB signalin...

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PMC11599565

II: Expression of MGMT (Methylated-DNA–protein-cysteine methyltransferase) DNA repair enzyme in OC236, sorted by EpCAM expression.

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PMC6267596

RNA Samples were assessed for quality with an Advanced Analytics Fragment Analyzer (High Sensitivity RNA Analysis Kit – Catalog # DNF-491 / User Guide DNF-491-2014AUG13) and quantity with a Qubit RNA quantification kit (Qubit® RNA HS Assay KitAssay Kit – Catalog # Q32852).

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PMC11769516

They also indicate a reduction in the number of genes for neurotrophic factors such as TH, BDNF and AADC, which makes DON-induced cell death associated with the impaired regulation of neurotransmitter release and reduced neuronal function .

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PMC9027909

From these subtypes, subtype (ST) 3 thought to be the most prevalent subtypes with wide distribution all over the world .

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PMC11699465

IFNGR1 acts as a key factor in regulating demethylase JMJD2D-induced PD-L1 expression in colorectal cancer.

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PMC11697065

We therefore characterized the clonal lines with respect to transgene copy number, mRNA transcript abundance, and protein expression.

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PMC9429973

Siltuximab—a monoclonal antibody against interleukin-6—is the only FDA- and EMA-approved treatment for iMCD.

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PMC8753818

:> 0.05, **:> 0.01, ***:> 0.001, ****:> 0.0001) Growth dynamics and cell viability: a Comparison of cell viability between CHO-K1 and CHO-KO cells during 24, 48 and 96 h. b Comparison of cell counting between CHO-K1and CHO-KO cells during 24, 48, 72 and 96 h. Results represent the average of three analyses (n = 5), and...

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PMC11470381

The choice of method depends on various parameters, including image quality, signal strength, and background noise level.

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PMC9429973

Results: A total of 26 pts were enrolled and treated; median (range) age was 65.0 (44–80) years, 25 (96.2%) had ECOG PS ≤1, 11 (42.3%) had ≥2 prior systemic therapies, and 6 (23.1%) had received prior bendamustine.

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PMC11753435

The dissociation constant (KD) for the purified uAbs to β-catenin was measured by BLI assays using an Octet RH16 instrument (Sartorius) at 30°C.

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PMC10033453

∗p < 0.05, ∗∗∗∗p < 0.0001. (

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PMC10734950

Densitometry was obtained using the Thermo Fisher iBright Densitometry analysis software.

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PMC11791432

1 × 10 cells per well were seeded in 96-well plates then cultured for 48 h in an incubator.

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PMC11704135

The plates were examined to observe any color changes.

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PMC6803987

As shown in Figure 2, after the sample was applied to the cells, the sample was able to improve cell growth and improve survival rate compared with the negative control group (* p < 0.05).

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PMC11653168

Total STAT3 expression remained constant, similar to in CCRF-CEM cells (Fig. 2B).

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PMC11470381

Live-cell imaging without CO2 supplementation and adequate humidification should be limited to shorter durations of no more than 30–40 min.

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PMC10213179

Various solid tumors, such as ovary, prostate, pancreas, glioblastoma, lung, melanoma, esophageal, colorectal, bone sarcomas, and breast, are reported to express high levels of the tyrosine kinase receptor EphA2.

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PMC6160470

A2780 and A2780/Adr cells were cultured for 72 h without treatment (CTRL) or treated with verapamil (10 μM,) or DAC-2Amide and DAC-3Amide (2 μM).

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PMC6600592

Preparation of Cyclohexyl 4-(4-substituted phenyl) -4-oxobutanoates (3) Compound 2 (2A, 2B, 2C, 2D, 15 mmol) reacted with cyclohexanol (30 mmol) in CH2Cl2 (20 mL) with p-methylbenzenesulfonic acid (TsOH) (2g, 11.6 mmol) under refluxing for 4 h (Scheme 1).

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PMC11412721

Gene set enrichment analysis (GSEA).

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PMC11607321

1Cancer multi-omics integration with MOSA.a Cancer cell line multi-omic datasets across the 1523 cancer cell lines.

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PMC11127909

Then, the images were photographed by the Leica DMi8 and analyzed by ImageJ (version 1.8.0).

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PMC10728200

The detection indexes of ferroptosis include the changes in mitochondrial morphology and levels of lipid ROS, Fe, and GSH .

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PMC11766332

Recently, miRNAs have gained prominence as important regulators of glycome .

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PMC11412721

Right, below: the Trp53 allele only enables the synthesis of proteins with the ‘canonical’ α C-terminus. (

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PMC9895440

Briefly, transcript count data was analyzed in R 4.2.1 using edgeR_3.38.4, limma_3.52.2, org.

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PMC9429973

Most pts received conditioning with melphalan 200mg/m for both transplants (1: 100%, 2: 96.2%).

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PMC6650823

Upon formation of a ternary complex POI–PROTAC–E3 ligase, the POI is ubiquitinated and degraded by the proteasome.

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PMC11621493

Selected gene set enrichment plots for “cytokine activity,” “chemokine activity” (GO mf), and “lipid catabolic process” (GO bp) are shown in Figure 9B–D. Here, multiple cytokines and chemokines (Ccl2, Ccl9, Cxcl1, Cxcl12, Cxcl2, Il1a, Il23a, Lif, Tnf) were significantly upregulated, indicating increased inflammation in...

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