OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11640247	Moreover, RAC3 interacts with numerous effectors beyond PAK1, MLK2, and N-WASP, suggesting that the p.R66W variant may disrupt other downstream signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10094992	Proteins were separated by SDS-PAGE under reducing conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "were", "separated", "by", "SDS-PAGE", "under", "reducing", "conditions", "." ] } ]
PMC11463018	H NMR (400 MHz, Chloroform-d) δ 7.95 (d, J = 8.0 Hz, 2H), 7.48 − 7.31 (m, 6H), 7.08 − 6.98 (m, 2H), 6.84 − 6.79 (m, 1H), 5.31 − 5.23 (m, 1H), 4.60 (d, J = 6.2 Hz, 2H), 3.88 (s, 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11590870	For the plant material, we used 20 Moringa oleifera Lam.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "plant", "material", ",", "we", "used", "20", "Moringa", "oleifera", ...
PMC11683240	A nonlinear regression model with variable slope (GraphPad Prism, log(inhibitor) versus response (variable slope, four parameters)) was fitted to values, and binding IC50 values were given based on the fit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	CHO-K1 cell line electrotransfection efficiency dependence on EP buffers composition (No. 1–8) and applied protocols with pEGFP-N1 plasmid encoding green fluorescent protein (GFP).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787381	Bambuterol (all doses) significantly prevented the hyperphosphorylation of Tau protein with a maximal effect observed at 10 nM (Fig.2C).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bambuterol", "(", ...
PMC11795610	Immunofluorescence staining was performed as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunofluorescence", "staining", "was", "performed", "as", "previously", "described", "." ] } ]
PMC10809689	Western blot analysis confirmed the results of RT-qPCR for mTORC and GLS protein expression in the THP-1 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", ...
PMC10213199	It also participates in the ubiquitin-proteasome pathway by interacting with the AU-rich RNA binding proteins Meanwhile the expression of HSPA1A helps specific immune system activation and inhibits cancer cell metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	This feature of biodistribution forms the basis for the use of these compounds in photodynamic therapy and fluorescence diagnostics of cancer as photosensitizers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11361748	Blots were developed using SuperSignal West Pico PLUS chemiluminescent substrate (Thermo Scientific #34580) or ECL Select Western Blotting Detection Reagent (Cytiva #RPN2235), and imaged using a FluorChem Q system (ProteinSimple).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	Plasmids encoding HA-tagged XRCC5 full-length and deletion mutants (N-terminal, C-terminal, and Ku domain) were synthesized and cloned in the pLenti-P2A-Puro vector using AsiSI and MluI restriction sites by Genewiz (ALENTA Life Sciences, Chelmsford, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	ADCC, antibody-dependent cellular cytotoxicity; AICC, antibody-independent cellular cytotoxicity; HI-FCS, heat-inactivated foetal calf serum; ns, non-significant; SMM, smouldering multiple myeloma; PBMCs, peripheral blood mononuclear cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11511922	In addition, the supplementary Figures S4A and S4C contain errors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", "supplementary", "Figures", "S4A", "and", "S4C", "contai...
PMC11052306	Both generation-zero dendrimers were also tested for preventing S. aureus biofilm formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "generation-zero", "dendrimers", "were", "also", "tested", "for", "preventing",...
PMC9611901	The slides were then neutralised with three portions of Tris-HCl buffer (0.4 mol/L; pH 7.5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "slides", "were", "then", "neutr...
PMC7022782	Besides particle size, other factors such as charge and shape influence the biodistribution profile of NPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", "particle", "size", ",", "other", ...
PMC9429973	Image: Summary/Conclusion: This study demonstrates that ~10% of Danish overweight AML-patients treated with IC are dose reduced ≥5% compared to full BSA-based doses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8623816	Meanwhile, we found that 33,089 R. solani AG-1 IA genes underwent AS, with 65,535 AS events in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", ...
PMC10887351	Hypoxia is significantly involved in the regulation of retinal vascularization-associated diseases by triggering neo-angiogenesis through VEGF release; thus, in mouse retinas, several studies focused on the production of VEGF through β3-AR activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11441402	Further analysis by fitting sigmoidal curves allowed the interpolation of GI50 and LC50 values, as summarized in Table 1 for each cell type, treatment, and assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11761919	Statistical analysis was performed by using the SPSS v26.0 (SPSS Inc., Chicago, IL, USA) through one-way analysis of variance (ANOVA) and Duncan's multiple-comparison procedures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792090	SAP UCAR-T therapy holds promise as a strategic approach for treating a diverse patient population with CD70-positive solid tumors, offering lower costs and greater convenience.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10419319	Furthermore, the evaluation for the determination of whether isoalantolactone induces a metabolic shift in glycolysis in cisplatin-resistant OC cells revealed that isoalantolactone treatment significantly decreased glucose consumption and lactate production in A2780 and SNU-8 cells (Figure 2D) but failed to do so in PE...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	D, D′) Higher magnification of the boxed regions in C, C’. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ",", "D′", ")", "Higher", "magnification", "...
PMC6102174	In continuing efforts to discover anti-HBV active compounds from Swertia, phytochemical investigation on S. patens led to the isolation of two new secoiridoids, swerpatic acid (104) and swerpalactone (105), together with 28 known compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10243817	Here, we specifically revealed that TGF-βR3 expression was markedly reduced in nasal epithelial cells in NPs, especially in eosinophilic type disease, and that expression was inversely correlated with levels of MEX3B.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11413393	To investigate the integrity of DNA DSB repair, we analyzed DNA repair efficiency following ionizing radiation (IR) exposure using the comet assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11697703	Left, expression in the electroporated primary somatosensory area (Elect-S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Left", ",", "expression", "in", "the", "electroporated", "primary", "somatosensory", ...
PMC11786767	B: Line scanning analysis of biotin-DHPE distribution across the chromosome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ":", "Line", "scanning", "analysis", "of", "biotin-DHPE", "distribution", "across", ...
PMC9019892	In the KIT‐T670I/BaF3‐ and GIST‐T1‐T670I‐inoculated mouse models, 100 mg·kg nintedanib nearly completely suppressed tumour growth, with TGI values of 93.3% and 80.3%, respectively, while imatinib showed a limited effect on tumour growth at the same doses (Fig. 3B,C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792766	Data are shown as mean + standard error of the mean (SEM) (n = 9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", ...
PMC11354239	However, contradictory findings show that TNFSF4 expression is associated with a poor prognosis in patients with diffuse gliomas .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "contradictory", "...
PMC9429973	Another patient developed pulmonary tuberculosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "patient", "developed", "pulmonary", "tuberculosis", "." ] } ]
PMC8623816	This phenomenon is known as hypovirulence .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "phenomenon", "is", "known", "as", "hypovirulence", "." ] } ]
PMC11541409	B. Emerging TKIs targeting MAPK/ERK, PI3K/AKT, mTORC1, and the cell cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B.", "Emerging", "TKIs", "targeting", "MAPK/ERK", ",", "PI3K/AKT", ...
PMC3035438	Relative concentration of chicken IgM and of chimera IgG secreted in the culture medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "concentration", "of", "chicken", "IgM", "and", "of", ...
PMC9622879	Figure 10Energy cost of each home in community with three CEMSs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "10Energy", "cost", "of", "each", "home", "in", "community", "with", "three"...
PMC7504302	Indeed, the tumors and the cell lines derived from this model were mainly characterized by genomic instability, upregulation of Myc, and hyperactivation of PI3K/Akt/mTor signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11047729	We discuss the role of human telomerase reverse transcriptase (hTERT), particularly its mRNA expression, as a potential therapeutic target, highlighting the promise of natural compounds in leukemia treatment and prevention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657744	The white asterisk () indicates cells expressing PCNA alone, while red asterisk () denotes cells expressing both PCNA and cilia. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11742290	In general, GPCRs are critical signal transducers that control vital physiological functions involving smooth muscle contraction, blood pressure regulation, neurotransmission, hormone, and immune responses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11026382	c Correlation between experimentally measured and model-predicted relative growth rates for seven DHFR variants in four TYMS backgrounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "Correlation", "between", "experimentall...
PMC11665555	However, if ATP production cannot sustain a continuous demand of nucleotides to inhibit gemcitabine integration in a competitive manner, the cells eventually succumb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8567602	When we tested for differential expression of genes annotated by differential enrichment for SMARCC1 and SMARCA4, we found that reduced BAF-family enrichment in a group of tumor genotypes associated with reduced expression of the annotated genes (Supplementary Fig. S3D and S3E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11186948	Fig. 6Whole-transcriptome RNA-seq analysis performed on LCLs from patient #249, RSTS and controls. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "6Whole-transcriptome", "RNA-seq", "analysis", "perfo...
PMC11507371	On the contrary, intracellular antioxidant levels of non-malignant HaCaT cells significantly increased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "On", "the", "contrary", ",", "intracellular", "antioxidant", "levels", ...
PMC11707577	Next, we evaluated the in vivo biodistribution of M13EGFR(TNP) in Hydra vulgaris.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "evaluated", "the", "in", "vivo", "biodistribu...
PMC11267036	Meanwhile, the control mice were administrated with an intragastric injection of the same amount of normal saline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", "the", "control", "mi...
PMC10530622	While few studies are dedicated to the topic, these promising results pave the way for novel paradigms in oxalate metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "few", "s...
PMC5963610	An image taken at the start time of therapies is observed in Figure 6A; Figure 6B–6E illustrate the results of treatment during 15 years, long lasting disease stabilization without changes on tumor size.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	e Tumor growth kinetics of individual tumors measured from date of inoculation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "e", "Tumor", "growth", "kinetics", "of", "individual", "tumors", "measured", "fr...
PMC11078693	•Check that the coated side of the cover glass is facing up.•Increase the g-force of centrifugation staying below 1000 g when spinning the cells down to attach them to the cover glass.•Increase the concentration of poly-lysine up to 0.1% when treating the cover glasses.•Try using Cell-Tak (Corning at 3.5 μg/cm) as an a...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687167	This regulatory network might facilitate further exploration of disease treatment strategies in combination with statins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "regulatory", "network", "might", "facilitate", "further",...
PMC10565698	In the colony formation assay, the number of colony-forming units was significantly lower in the group transfected with the interfering vector than in the control (Fig. 2I–K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	Subsequently, ELNAT1 was confirmed to be packaged into EVs secreted by bladder cancer cells by UBC9-induced SUMOylation of hnRNPA1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "ELNAT1"...
PMC11774112	Size-related values represent mean ± SD of 3 repeated measurements. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Size-related", "values", "represent", "mean", "±", "SD", "of", "3", "repeated", "meas...
PMC9429973	The estimated median Overall Survival resulted of 28 ± 4.9 (95%CI range 18- 37) months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "estimated", "median", "Overall", "Survival...
PMC9712534	We also found that TOP2B H58Y was insensitive to ICRF-187 (Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "found", "that", "TOP2B", "H58Y", "was", "insensiti...
PMC11509224	Hence, the compound darwinolide displays 4-fold selectivity against the biofilm phase of MRSA compared to the planktonic phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "the", "compound", ...
PMC11727638	cDNA was synthesized from DNase-treated RNA using the PrimeScript™ FAST RT reagent Kit with gDNA Eraser (Takara Bio).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "cDNA", "was", "sy...
PMC11768927	Strategies include the engineering of novel VSV constructs that exhibit enhanced replication within resistant cell types, the inhibition of IFN responses, modulation of the TME, the combination of VSV with immune checkpoint inhibitors (ICIs), as well as the co-administration of VSV with chemotherapeutic and radiotherap...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11281366	Viruses produced by cells treated with miRNA-26a mimics displayed an enhanced susceptibility to ADCML in the presence of Abs from sera #163 (2.1-fold, p = 0.0260) or #497 (1.6-fold, p = 0.0649) as compared to controls (Figure 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628904	Scale bar = 100 and 20 μm (inset). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "100", "and", "20", "μm", "(", "inset", ")", ".", "("...
PMC10999934	8Validation of FBXO2 expression. (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "8Validation", "of", "FBXO2", "expression", ".", "(" ] } ]
PMC11770746	One approach to overcome the drawbacks of Pt(II) drugs is to utilize Pt(IV) complexes as prodrugs that deliver the Pt(II) drugs to the tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: In MM cells, the expression of CD155 is regulated by the methylation status of its promoter region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "I...
PMC8567602	In synovial sarcoma cells, CBAF relative abundance was significantly reduced (Fig. 6C; Supplementary Fig. S5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "synovial", "sarcoma", "cell...
PMC8973725	Over the last few decades, a substantial body of literature has revealed that ZNFs play a crucial role in the occurrence and development of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11767725	Postbiotics, including short-chain fatty acids (SCFAs) like acetate, propionate, and butyrate, produced by probiotic fermentation, have been shown to exert anti-inflammatory and antimicrobial effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11483468	T-GFP, TAT-GFP; GST, glutathione-S-transferase; LPTS39, LPTS290-328; PBS, phosphate buffered saline; TAT, HIV transcription activator of transcription protein; GFP, green fluorescent protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144382	NFIX isoform1, representing the canonical sequence, is a ubiquitously expressed 502 amino acid protein, which contains a conserved 194 amino acid N-terminal DNA binding and dimerization domain, and a C-terminal transactivation/repression domain of variable length, due to alternative splicing of exons 7 and 9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	CCs were included as controls to determine the original stability of WT-KIT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCs", "were", "included", "as", "controls", "to", "determine", "the", "original"...
PMC11098378	To determine if IpaH4 can also alter the levels of moth-encoded SHOC2 and PSMC1 proteins, we co-transfected Flag-tagged versions of these putative moth targets into LD652 cells in the absence or presence of GFP-IpaH4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711935	NRG1 mediates melanogenesis via the PI3K/Akt pathway, increasing melanocyte proliferation, survival, and melanin synthesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NRG1", "mediates", "melanogenesis", "via", "the",...
PMC11365983	Automatic quantification of cilia length from confocal microscopy images was performed with Cell Profiler.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Automatic", "quantification", "of", "cilia", "length", "from", "confoc...
PMC11783017	By regulating the levels of MYC and ICD, the proportion of M1 macrophages and mature dendritic cells were enhanced and thereby strengthening anti-tumor immunity to inhibit MYC-amplified osteosarcoma growth and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10745221	PRMT7 is a Type III enzyme, which only forms MMA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PRMT7", "is", "a", "Type", "III", "enzyme", ",", "which", "only", "forms", "MMA...
PMC10178190	Our previous report showed that platinum chemoresistance mediated by direct interaction of MSCs with OC cells involves ERK1/2 inactivation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "previous", "report", "show...
PMC5311252	Global transcriptomics, proteomics and target prediction resulted in the identification of several tumor suppressors involved in the G1/S transition as AAGUGC-miRNA targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Global"...
PMC8728081	From the TEM (Fig. 2b) studies, it was confirmed that Kajjali had some nano-sized particles below 100 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "the", "TE...
PMC9454178	C, D qRT–PCR and immunofluorescence assays showed that c-KIT expression changed after THZ1 treatment in GIST-T1 and GIST-882 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "...
PMC11786704	P values: ns P > 0.05, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, all the values are expressed as mean ± SD, n = 3). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10958426	The dramatic differences between the cells in tumor tissue and their counterpart in normal tissue could be attributed to their different tissue microenvironments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	S. Aggarwal, S. Kumar, A. Bela, O. Topaloglu Health Economics and Outcomes Research; Systematic Literature Review, NOVEL Health Strategies, Chevy Chase, United States of America Background: Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation that affe...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720808	Data are presented as the mean ± SD (n=5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", "SD", "(", "n=5", ")", ...
PMC11225860	Aurkin A treated cells failing to progress through G2 is consistent with the findings in Fig. 5a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aurkin", "A", "treated", "cells", "failing", ...
PMC9429973	In the DA DISC phase, 35 pts who attained MR4 or deeper response for ≥ 12 months discontinued DA for a TFR2 attempt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11409031	As a result, the leading 100 genes from the turquoise, pink, yellow, red, blue, black, and green modules were chosen as hub genes for further analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11319300	Search sensitivity for BLAST was set to distant homologies and Maximum E-value in which a hit would be reported was set to 1, the rest of the parameters were left as by default.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	Pharmacological inhibition of STAT3 by ART could overcome the resistance of basal cells to RC48.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pharmacological", "inhibition", "of", "STAT3", "by", "ART", ...
PMC5386478	To investigate the effect of TG2 on MPM cells under hypoxia, we established MPM hypoxic cell models in vitro, by placing cells in an environmentally controlled chamber in which oxygen levels in the gas phase were maintained at 1%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Overall RR was significantly increased in pts with DEL (66.6%(14/21) DEL+ vs 16.1%(5/31) DEL-, p<0,001) and with EL(60%(9/15) EL+ vs 18.1%(10/55) EL-, p=0.04).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	The whiskers indicate the fifth and the ninety-fifth percentiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "whiskers", "indicate", "the", "fifth", "and", "the", "ninety-fifth", "percentiles", "." ] } ]
PMC9512971	Even in a state of emergency, the doses in clinical trials should be carefully selected with consideration of clinical pharmacology, including PK/PD modeling and simulation, when planning clinical trials for a new drug candidate in settings such as this, in order to provide clear evidence supporting or halting ongoing ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540611	In the case of AuNP15, there was a significant difference in apoptosis for the target and random sequences for both cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9966931	The bioactivities exerted by essential oils containing eugenol are generally attributed to this compound .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bioactivities", "exerted", "by", "essential", "oils", "containi...
PMC9429973	Results: As of Oct 04, 2021, 32 patients received navitoclax plus ruxolitinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "As", "of", "Oct", "04", ",", "2021", ...
PMC11592008	Consistently, we observed a significant increase in cell death in PKs upon talabostat treatment in contrast to the immortalized cell lines (Figure 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11640247

Moreover, RAC3 interacts with numerous effectors beyond PAK1, MLK2, and N-WASP, suggesting that the p.R66W variant may disrupt other downstream signaling pathways.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10094992

Proteins were separated by SDS-PAGE under reducing conditions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "were", "separated", "by", "SDS-PAGE", "under", "reducing", "conditions", "." ] } ]

PMC11463018

H NMR (400 MHz, Chloroform-d) δ 7.95 (d, J = 8.0 Hz, 2H), 7.48 − 7.31 (m, 6H), 7.08 − 6.98 (m, 2H), 6.84 − 6.79 (m, 1H), 5.31 − 5.23 (m, 1H), 4.60 (d, J = 6.2 Hz, 2H), 3.88 (s, 3H).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11590870

For the plant material, we used 20 Moringa oleifera Lam.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "plant", "material", ",", "we", "used", "20", "Moringa", "oleifera", ...

PMC11683240

A nonlinear regression model with variable slope (GraphPad Prism, log(inhibitor) versus response (variable slope, four parameters)) was fitted to values, and binding IC50 values were given based on the fit.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11266100

CHO-K1 cell line electrotransfection efficiency dependence on EP buffers composition (No. 1–8) and applied protocols with pEGFP-N1 plasmid encoding green fluorescent protein (GFP).

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11787381

Bambuterol (all doses) significantly prevented the hyperphosphorylation of Tau protein with a maximal effect observed at 10 nM (Fig.2C).Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bambuterol", "(", ...

PMC11795610

Immunofluorescence staining was performed as previously described.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunofluorescence", "staining", "was", "performed", "as", "previously", "described", "." ] } ]

PMC10809689

Western blot analysis confirmed the results of RT-qPCR for mTORC and GLS protein expression in the THP-1 cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", ...

PMC10213199

It also participates in the ubiquitin-proteasome pathway by interacting with the AU-rich RNA binding proteins Meanwhile the expression of HSPA1A helps specific immune system activation and inhibits cancer cell metastasis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11721277

This feature of biodistribution forms the basis for the use of these compounds in photodynamic therapy and fluorescence diagnostics of cancer as photosensitizers .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...

PMC11361748

Blots were developed using SuperSignal West Pico PLUS chemiluminescent substrate (Thermo Scientific #34580) or ECL Select Western Blotting Detection Reagent (Cytiva #RPN2235), and imaged using a FluorChem Q system (ProteinSimple).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11676169

Plasmids encoding HA-tagged XRCC5 full-length and deletion mutants (N-terminal, C-terminal, and Ku domain) were synthesized and cloned in the pLenti-P2A-Puro vector using AsiSI and MluI restriction sites by Genewiz (ALENTA Life Sciences, Chelmsford, MA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11472639

ADCC, antibody-dependent cellular cytotoxicity; AICC, antibody-independent cellular cytotoxicity; HI-FCS, heat-inactivated foetal calf serum; ns, non-significant; SMM, smouldering multiple myeloma; PBMCs, peripheral blood mononuclear cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11511922

In addition, the supplementary Figures S4A and S4C contain errors.

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PMC11052306

Both generation-zero dendrimers were also tested for preventing S. aureus biofilm formation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "generation-zero", "dendrimers", "were", "also", "tested", "for", "preventing",...

PMC9611901

The slides were then neutralised with three portions of Tris-HCl buffer (0.4 mol/L; pH 7.5).

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PMC7022782

Besides particle size, other factors such as charge and shape influence the biodistribution profile of NPs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", "particle", "size", ",", "other", ...

PMC9429973

Image: Summary/Conclusion: This study demonstrates that ~10% of Danish overweight AML-patients treated with IC are dose reduced ≥5% compared to full BSA-based doses.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8623816

Meanwhile, we found that 33,089 R. solani AG-1 IA genes underwent AS, with 65,535 AS events in this study.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", ...

PMC10887351

Hypoxia is significantly involved in the regulation of retinal vascularization-associated diseases by triggering neo-angiogenesis through VEGF release; thus, in mouse retinas, several studies focused on the production of VEGF through β3-AR activity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11441402

Further analysis by fitting sigmoidal curves allowed the interpolation of GI50 and LC50 values, as summarized in Table 1 for each cell type, treatment, and assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11761919

Statistical analysis was performed by using the SPSS v26.0 (SPSS Inc., Chicago, IL, USA) through one-way analysis of variance (ANOVA) and Duncan's multiple-comparison procedures.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11792090

SAP UCAR-T therapy holds promise as a strategic approach for treating a diverse patient population with CD70-positive solid tumors, offering lower costs and greater convenience.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC10419319

Furthermore, the evaluation for the determination of whether isoalantolactone induces a metabolic shift in glycolysis in cisplatin-resistant OC cells revealed that isoalantolactone treatment significantly decreased glucose consumption and lactate production in A2780 and SNU-8 cells (Figure 2D) but failed to do so in PE...

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PMC11033180

D, D′) Higher magnification of the boxed regions in C, C’. (

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PMC6102174

In continuing efforts to discover anti-HBV active compounds from Swertia, phytochemical investigation on S. patens led to the isolation of two new secoiridoids, swerpatic acid (104) and swerpalactone (105), together with 28 known compounds.

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PMC10243817

Here, we specifically revealed that TGF-βR3 expression was markedly reduced in nasal epithelial cells in NPs, especially in eosinophilic type disease, and that expression was inversely correlated with levels of MEX3B.

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PMC11413393

To investigate the integrity of DNA DSB repair, we analyzed DNA repair efficiency following ionizing radiation (IR) exposure using the comet assay.

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PMC11697703

Left, expression in the electroporated primary somatosensory area (Elect-S1).

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PMC11786767

B: Line scanning analysis of biotin-DHPE distribution across the chromosome.

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PMC9019892

In the KIT‐T670I/BaF3‐ and GIST‐T1‐T670I‐inoculated mouse models, 100 mg·kg nintedanib nearly completely suppressed tumour growth, with TGI values of 93.3% and 80.3%, respectively, while imatinib showed a limited effect on tumour growth at the same doses (Fig. 3B,C).

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PMC11792766

Data are shown as mean + standard error of the mean (SEM) (n = 9).

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PMC11354239

However, contradictory findings show that TNFSF4 expression is associated with a poor prognosis in patients with diffuse gliomas .

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PMC9429973

Another patient developed pulmonary tuberculosis.

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PMC8623816

This phenomenon is known as hypovirulence .

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PMC11541409

B. Emerging TKIs targeting MAPK/ERK, PI3K/AKT, mTORC1, and the cell cycle.

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PMC3035438

Relative concentration of chicken IgM and of chimera IgG secreted in the culture medium.

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PMC9622879

Figure 10Energy cost of each home in community with three CEMSs.

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PMC7504302

Indeed, the tumors and the cell lines derived from this model were mainly characterized by genomic instability, upregulation of Myc, and hyperactivation of PI3K/Akt/mTor signaling.

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PMC11047729

We discuss the role of human telomerase reverse transcriptase (hTERT), particularly its mRNA expression, as a potential therapeutic target, highlighting the promise of natural compounds in leukemia treatment and prevention.

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PMC11657744

The white asterisk (*) indicates cells expressing PCNA alone, while red asterisk (*) denotes cells expressing both PCNA and cilia. (

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PMC11742290

In general, GPCRs are critical signal transducers that control vital physiological functions involving smooth muscle contraction, blood pressure regulation, neurotransmission, hormone, and immune responses .

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PMC11026382

c Correlation between experimentally measured and model-predicted relative growth rates for seven DHFR variants in four TYMS backgrounds.

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PMC11665555

However, if ATP production cannot sustain a continuous demand of nucleotides to inhibit gemcitabine integration in a competitive manner, the cells eventually succumb.

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PMC8567602

When we tested for differential expression of genes annotated by differential enrichment for SMARCC1 and SMARCA4, we found that reduced BAF-family enrichment in a group of tumor genotypes associated with reduced expression of the annotated genes (Supplementary Fig. S3D and S3E).

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PMC11186948

Fig. 6Whole-transcriptome RNA-seq analysis performed on LCLs from patient #249, RSTS and controls. (

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PMC11507371

On the contrary, intracellular antioxidant levels of non-malignant HaCaT cells significantly increased.

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PMC11707577

Next, we evaluated the in vivo biodistribution of M13EGFR(TNP) in Hydra vulgaris.

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PMC11267036

Meanwhile, the control mice were administrated with an intragastric injection of the same amount of normal saline.

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PMC10530622

While few studies are dedicated to the topic, these promising results pave the way for novel paradigms in oxalate metabolism.

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PMC5963610

An image taken at the start time of therapies is observed in Figure 6A; Figure 6B–6E illustrate the results of treatment during 15 years, long lasting disease stabilization without changes on tumor size.

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PMC11638255

e Tumor growth kinetics of individual tumors measured from date of inoculation.

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PMC11078693

•Check that the coated side of the cover glass is facing up.•Increase the g-force of centrifugation staying below 1000 g when spinning the cells down to attach them to the cover glass.•Increase the concentration of poly-lysine up to 0.1% when treating the cover glasses.•Try using Cell-Tak (Corning at 3.5 μg/cm) as an a...

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PMC11687167

This regulatory network might facilitate further exploration of disease treatment strategies in combination with statins.

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PMC10565698

In the colony formation assay, the number of colony-forming units was significantly lower in the group transfected with the interfering vector than in the control (Fig. 2I–K).

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PMC11755519

Subsequently, ELNAT1 was confirmed to be packaged into EVs secreted by bladder cancer cells by UBC9-induced SUMOylation of hnRNPA1.

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PMC11774112

Size-related values represent mean ± SD of 3 repeated measurements. (

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PMC9429973

The estimated median Overall Survival resulted of 28 ± 4.9 (95%CI range 18- 37) months.

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PMC9712534

We also found that TOP2B H58Y was insensitive to ICRF-187 (Fig. 3).

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PMC11509224

Hence, the compound darwinolide displays 4-fold selectivity against the biofilm phase of MRSA compared to the planktonic phase.

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PMC11727638

cDNA was synthesized from DNase-treated RNA using the PrimeScript™ FAST RT reagent Kit with gDNA Eraser (Takara Bio).

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PMC11768927

Strategies include the engineering of novel VSV constructs that exhibit enhanced replication within resistant cell types, the inhibition of IFN responses, modulation of the TME, the combination of VSV with immune checkpoint inhibitors (ICIs), as well as the co-administration of VSV with chemotherapeutic and radiotherap...

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PMC11281366

Viruses produced by cells treated with miRNA-26a mimics displayed an enhanced susceptibility to ADCML in the presence of Abs from sera #163 (2.1-fold, p = 0.0260) or #497 (1.6-fold, p = 0.0649) as compared to controls (Figure 6D).

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PMC11628904

Scale bar = 100 and 20 μm (inset). (

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PMC10999934

8Validation of FBXO2 expression. (

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PMC11770746

One approach to overcome the drawbacks of Pt(II) drugs is to utilize Pt(IV) complexes as prodrugs that deliver the Pt(II) drugs to the tumor.

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PMC9429973

Summary/Conclusion: In MM cells, the expression of CD155 is regulated by the methylation status of its promoter region.

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PMC8567602

In synovial sarcoma cells, CBAF relative abundance was significantly reduced (Fig. 6C; Supplementary Fig. S5).

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PMC8973725

Over the last few decades, a substantial body of literature has revealed that ZNFs play a crucial role in the occurrence and development of cancer.

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PMC11767725

Postbiotics, including short-chain fatty acids (SCFAs) like acetate, propionate, and butyrate, produced by probiotic fermentation, have been shown to exert anti-inflammatory and antimicrobial effects.

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PMC11483468

T-GFP, TAT-GFP; GST, glutathione-S-transferase; LPTS39, LPTS290-328; PBS, phosphate buffered saline; TAT, HIV transcription activator of transcription protein; GFP, green fluorescent protein.

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PMC11144382

NFIX isoform1, representing the canonical sequence, is a ubiquitously expressed 502 amino acid protein, which contains a conserved 194 amino acid N-terminal DNA binding and dimerization domain, and a C-terminal transactivation/repression domain of variable length, due to alternative splicing of exons 7 and 9.

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PMC10589262

CCs were included as controls to determine the original stability of WT-KIT.

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PMC11098378

To determine if IpaH4 can also alter the levels of moth-encoded SHOC2 and PSMC1 proteins, we co-transfected Flag-tagged versions of these putative moth targets into LD652 cells in the absence or presence of GFP-IpaH4.

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PMC11711935

NRG1 mediates melanogenesis via the PI3K/Akt pathway, increasing melanocyte proliferation, survival, and melanin synthesis .

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PMC11365983

Automatic quantification of cilia length from confocal microscopy images was performed with Cell Profiler.

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PMC11783017

By regulating the levels of MYC and ICD, the proportion of M1 macrophages and mature dendritic cells were enhanced and thereby strengthening anti-tumor immunity to inhibit MYC-amplified osteosarcoma growth and metastasis.

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PMC10745221

PRMT7 is a Type III enzyme, which only forms MMA .

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PMC10178190

Our previous report showed that platinum chemoresistance mediated by direct interaction of MSCs with OC cells involves ERK1/2 inactivation .

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PMC5311252

Global transcriptomics, proteomics and target prediction resulted in the identification of several tumor suppressors involved in the G1/S transition as AAGUGC-miRNA targets.

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PMC8728081

From the TEM (Fig. 2b) studies, it was confirmed that Kajjali had some nano-sized particles below 100 nm.

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PMC9454178

C, D qRT–PCR and immunofluorescence assays showed that c-KIT expression changed after THZ1 treatment in GIST-T1 and GIST-882 cells.

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PMC11786704

P values: ns P > 0.05, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, all the values are expressed as mean ± SD, n = 3). (

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PMC10958426

The dramatic differences between the cells in tumor tissue and their counterpart in normal tissue could be attributed to their different tissue microenvironments.

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PMC9429973

S. Aggarwal, S. Kumar, A. Bela, O. Topaloglu Health Economics and Outcomes Research; Systematic Literature Review, NOVEL Health Strategies, Chevy Chase, United States of America Background: Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation that affe...

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PMC11720808

Data are presented as the mean ± SD (n=5).

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PMC11225860

Aurkin A treated cells failing to progress through G2 is consistent with the findings in Fig. 5a.

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PMC9429973

In the DA DISC phase, 35 pts who attained MR4 or deeper response for ≥ 12 months discontinued DA for a TFR2 attempt.

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PMC11409031

As a result, the leading 100 genes from the turquoise, pink, yellow, red, blue, black, and green modules were chosen as hub genes for further analysis.

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PMC11319300

Search sensitivity for BLAST was set to distant homologies and Maximum E-value in which a hit would be reported was set to 1, the rest of the parameters were left as by default.

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PMC11747467

Pharmacological inhibition of STAT3 by ART could overcome the resistance of basal cells to RC48.

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PMC5386478

To investigate the effect of TG2 on MPM cells under hypoxia, we established MPM hypoxic cell models in vitro, by placing cells in an environmentally controlled chamber in which oxygen levels in the gas phase were maintained at 1%.

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PMC9429973

Overall RR was significantly increased in pts with DEL (66.6%(14/21) DEL+ vs 16.1%(5/31) DEL-, p<0,001) and with EL(60%(9/15) EL+ vs 18.1%(10/55) EL-, p=0.04).

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PMC11657695

The whiskers indicate the fifth and the ninety-fifth percentiles.

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PMC9512971

Even in a state of emergency, the doses in clinical trials should be carefully selected with consideration of clinical pharmacology, including PK/PD modeling and simulation, when planning clinical trials for a new drug candidate in settings such as this, in order to provide clear evidence supporting or halting ongoing ...

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PMC8540611

In the case of AuNP15, there was a significant difference in apoptosis for the target and random sequences for both cell lines.

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PMC9966931

The bioactivities exerted by essential oils containing eugenol are generally attributed to this compound .

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PMC9429973

Results: As of Oct 04, 2021, 32 patients received navitoclax plus ruxolitinib.

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PMC11592008

Consistently, we observed a significant increase in cell death in PKs upon talabostat treatment in contrast to the immortalized cell lines (Figure 4B).

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