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PMC11300639
Protein signals were visualized using ECL detection reagent (Termo Fisher Scientifc, USA) and ChemiDoc XRS (Bio-Rad Laboratories, USA).
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PMC11389534
Under physiological conditions, T‐cell stimulation triggered by antigens leads to immune responses mediated by effector T lymphocytes and memory T cells.
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PMC11739484
Following a 1-hour blocking step with 5% non-fat milk at room temperature, the PVDF membranes underwent three 10-minute washes with phosphate-buffered saline (PBS).
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PMC10955424
cPARP was also detected using PathScan cPARP ELISA kit (Cell Signaling Technology, Danvers, Massachusetts, USA) and median OD 450 nm relative to control platinum-treated cells was calculated (F); malignant ascites n = 6, cirrhosis ascites n = 3, chemoresistance-inducing cirrhosis ascites n = 1.
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PMC9429973
Aims: To link bleeding phenotype or thrombosis incidence to desialylated platelets in adults with primary ITP.
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PMC8193046
However, our results indicate that these substructures have generally a positive impact on broad-spectrum ABCB1, ABCC1, and ABCG2 inhibition, depending on the composition of and combination with other substructures.
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PMC10882807
qRT-PCR analysis revealed that si-hsa_circ_0005397 (si1, si2) significantly silenced expression of hsa_circ_0005397 in HCCLM3 and BEL-7404 cells but that high-efficiency overexpression was observed in SK-Hep1 cells (Fig. 2B).
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PMC9386809
311 mg (92% yield); white solid mp 123–125 °C; H NMR (400 MHz, DMSO-d6): δ 5.71 (s, 1H, CH), 6.66 (d, 2H, J = 8.4 Hz, CH=C), 6.79 (s, 2H), 6.86 (d, 2H, J = 7.7 Hz, Ar), 7.03 (t, 2H, J = 8.0 Hz, Ar), 7.15 (d, 2H, J = 8.0 Hz, Ar), 7.28 (d, 2H, J = 8.4 Hz, Ar), 7.35 (d, 2H, J = 8.4 Hz, Ar), 9.17 (s, 1H, OH), 10.79 (s, 2H,...
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PMC11682525
The relative expression levels of HIF1α, BDNF, and VEGF were assessed in both hypoxia-preconditioned cell types.
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PMC11766350
rAAVs are commonly produced by transiently transfecting HEK293F cells with 3 plasmids encoding the ITR-flanked therapeutic transgene, the rAAV replication and capsid genes (rep and cap) and Adenovirus-derived helper genes, respectively.
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PMC6102174
In order to characterized the active constituents, detailed investigation on the stems and roots of I. henryi yielded 39 compounds, involving 7 new ones.
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PMC11794847
To knock down HVEM and GPT2 expression, corresponding shRNA construct specifically targeting the HVEM and GPT2 gene was employed, and for overexpression, a plasmid encoding GPT2 was utilized.
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PMC11144382
The phenotypic differences between humans and mice in this case were demonstrated to be due to auto-catalytic MMP13 enzyme activity induced by the mutant which degraded the WT MMP13, thereby exerting a dominant effect and leading to a deficiency in MMP13 that was similar in Mmp13 mice, which developed skeletal abnormal...
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PMC9429973
One ATLL patient had mutations in TRAF3, FAT1 and MED12.
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PMC10588957
HepG2 cells were seeded in a 6-well plate (Corning, USA) at a density of 500 cells per well, with a volume of 50 µL/well.
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PMC10203589
Further studies on more signaling pathways mediated by FGF18 and cell surface CD44 will provide new ideas for the diagnosis, treatment and prognosis of CRC.
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PMC9587298
As observed, Bastardeira rich-phenolic extract showed a dose-dependent protective effect (Fig. 6c, right panel), with significant improvement of cell viability at 50 and 200 µg/mL of Ba rich-phenolic extract against 2 mM MGO, being the cell viability equal to 62.98 ± 4.81 % and 71.37 ± 3.81 %, respectively (p < 0.0001,...
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PMC10523483
Double-blind evaluation was performed as previously described (48) by scoring from 0 to 6, which correspond to a sum-up of staining intensity scores (0 to 3 from none to strong staining) and positive staining scores (0 to 3 from 0 to 100% positively stained cells per field).
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PMC7153288
The raw sequencing data are available in the Sequence Read Archive (SRA) database under the accession number SRX6989938 at https://www.ncbi.nlm.nih.gov/sra/SRX6989938[accn].
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PMC11787355
tumor model.
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PMC9429973
Currently we are working on machine learning approach to identify relevant mutation characteristics and modes of action as well as to screen cancer genome databases for mutational signature occurrence.
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PMC6889484
In future studies, it may be possible to shorten the A3 portion and shift the ∼900-bp direct repeat to suppress the ∼2-fold inhibition of lentivector transduction.
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PMC10969097
In another study, the authors used 4-acetylanthroquinonol B (a bioactive isolate from the mycelia of Antrodia camphorata) on human colon carcinoma cell lines derived from different tumours (DLD-1, HCT-116, SW-480, HT-29 and RKO cells).
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PMC9429973
The Talkwalker tool was used to collect and aggregate publicly available data.
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PMC11566417
Cell suspensions were dropped in single droplets from 2 m height onto the slides.
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PMC11806182
Plasma exosomal miRNA data were obtained from the Gene Expression Omnibus (GEO) database (GSE142819) which included 15 PCOS samples and 15 control samples .
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PMC11615828
The worms were then allowed to acclimate to swimming behavior in darkness for 15 min.
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PMC11222184
Kim et al. revealed that the HSP90 inhibitor geldanamycin reduced cell viability in the SH-SY5Y human neuroblastoma cell line and induced the apoptotic pathway via caspase activation, mitochondrial release of cytochrome c, and subsequent PARP cleavage .
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PMC11792740
Based on existing research, Liang et al. concluded that TCRs specifically recognize antigen peptides presented by major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells and convert extracellular recognition signals into intracellular signals.
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PMC9429973
Of patients reaching 12-month follow-up post MM-diagnosis, 6.4% received Ig and of patients reaching 24-month follow-up, 7.0% received Ig.
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PMC11078693
Note: Floating or loosely attached cells do not interfere with the analyses as they are readily distinguished in a Z stack.
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PMC9429973
On top of that, cells with TLX3(F18E) and FLT3-ITD were able to grow in the absence of stem cell factor (Scf).
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PMC10454535
These proteins’ expression decreased in a similar trend to cytotoxicity and apoptosis induction data, with PIN treatment decreasing overall protein expression compared to control, followed by a further decrease in the BTZ treatment and then the PIN/BTZ treatment.
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PMC9429973
The ongoing PTG-300-04 (NCT04057040) Phase 2 study of Rusfertide in TP-dependent PV patients experienced an FDA-mandated brief hold which resulted in dosing interruption of Rusfertide for all patients.
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PMC6803987
After 21 days of treatment, there was no significant difference in feather color, body weight, food intake, irritation response and mental state between the esculetin groups and the model control group.
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PMC11674834
3,4-Dimethylaniline (3,4-DMA) is present in cigarette smoke and widely used as an intermediate in dyes, drugs, and pesticides.
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PMC11541241
In conclusion, this study offered a novel histone‐based avenue for antifungal discovery.
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PMC9792775
MYC and BCL-2 were downstream genes of JAK2/STAT3 signal pathway (Ok et al., 2014), and the Western blot analysis showed that the expressions of c-MYC and BCL-2 were significantly downregulated, which could enhance the apoptosis consequently.
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PMC11659734
Preliminary results showed that BPP induced chromosomal damage in an in vitro micronucleus test in human peripheral blood lymphocytes.
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PMC9429973
Key secondary endpoints included the proportion of patients achieving a complete or very good partial response (CR or VGPR), duration of response (DOR), Time to response (TOR), disease burden, and safety.
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PMC11803149
n = 3 per condition. (
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PMC11763111
The LLT1 coding sequence is ligated to the CD3z domain, forming the CD38-LLT1 CAR containing LLT1.
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PMC11697703
Pups electroporated with FEZF2-HA were employed for ChIP-qPCR at P2, and pups electroporated with miR-365 and miR-193b constructs were collected for analysis at P14.
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PMC11703992
On contrary, the Augur scores of different T subclusters in old and GCA samples revealed that CD4+ Memory T cells were most insensitive to perturbation of GCA (Fig. S2A).
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PMC5034105
Viral tropism for the retinal (ARPE19) cell line corroborates with the ophthalmological complications of congenital ZIKV infection, including chorioretinal atrophy and pigmentary maculopathy.
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PMC11507371
Nevertheless, examinations focusing on the translocation pattern of Nrf2 in A431 cells or other SCC cells upon CAP treatment have not been conducted before.
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PMC8584666
The absorbance was measured at 405 nm using a microplate reader (Sunrise Remote, TECAN, Männedorf, Switzerland).
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PMC11487720
C Under similar conditions, WWOXd 4T1 cells had little or no increased production of NO.
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PMC9429973
Median number of cycles given was 2 (range, 1-3).
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PMC10813895
The ELF5 clock could provide a nuanced and biologically relevant framework for conducting breast cancer prevention trials, addressing many of the challenges associated with these types of studies.
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PMC9429973
P. Reichelt, S. Bernhart, F. Wilke, U. Platzbecker, M. Cross, G. Behre Department of Hematology and Cell Therapy, University Hospital Leipzig; Interdisciplinary center for bioinformatics Leipzig, Leipzig; Clinic for Internal Medicine I, Municipal Hospital Dessau, Dessau, Germany Background: Acute myeloid leukemia (AML)...
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PMC11310713
Data are means ± SEM.
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PMC11802929
c Radar graphs of physicochemical properties for representative PG-TCR groups.
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PMC11791264
D, A2780 cells that stably express shNC or shSETD7-1 were transfected with GFP-LC3B in the absence or presence of Baf A1 (100 nM) for 10 h. Left panels show the representative images of LC3B puncta, and the right panels show the quantification of LC3B puncta.
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PMC11705484
Images and weights of tumours dissected from the mice after treatment with NC, DDP, CMP1, CMP9 or Thiram, when the mice were culled 30 days post‐treatment. (
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PMC11474209
Exposure to cyanobacteria-blooming water changed the kidneys' mRNA and protein translation patterns of ER stress signaling components .
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PMC5963610
Recently, NGcGM3 expression has been associated with a poor prognostic in colon and non-small cell lung cancer (NSCLC) .
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PMC9429973
Median follow up duration was 4.7 years (range: 0.1-23.7).
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PMC11033180
No difference was observed between the control Fc and the Sema5A mutants, S951C or S956G, at both 60 and 160 μm from the center of the ganglion (Figure 4C).
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PMC11529598
p < 0.05.
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PMC4485648
Thus, we assume that SFN can partially overcome the chemoresistance of ovarian cancer cells.
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PMC11757230
Compared to LL cells cultured alone, direct co-culture with cADSCs at a 1:1 ratio for 72 h significantly induced apoptosis in the TCL cell lines CLC, CLK, Ema, and CL-1.
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PMC11489351
Figures 1D, 4, B and D, 6, A and C, S7, A and C were prepared using the Nikon NIS Elements AR software.
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PMC11470381
Specify the channels (fluorescence signals for Piezo1 mCherry and actin-GFP) and delete the stacks (or slices) and time frames that are not essential for the analysis from either/both ends of the range.
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PMC11286266
Volocity software was used for co-localisation quantification.
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PMC9325715
Moreover, bands at 914 cm and 850 cm that become visible after Fe adsorption onto bLTF may correspond to νCO + δCCH + νasy (ring of pyranose) and νCC + δCCH + δCH(β-pyranose).
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PMC11761919
Although the levels of neutralizing antibodies between the Micro-E/Fiber2-PINs and Micro-E/Fiber2-inulin group did not show statistical differences (p > 0.05), both groups had higher levels than the negative control and Micro control groups (p < 0.001).Fig.
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PMC11026382
DHFR is a 159 amino acid enzyme that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate (THF) using NADPH as a cofactor.
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PMC11670407
c, d 143B or U2OS cells were transfected with the overexpression plasmids shown after treatment with CHX (100 μM) for the indicated times before harvesting the cells.
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PMC11544122
Endocytosis was calculated as a decrease in cell surface receptors in agonist-treated cells compared with vehicle-treated cells after background subtraction from cells not transfected with the receptor.
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PMC9688728
The mechanisms of perturbations of the molecular makeup in response to internal or external changes often remain poorly understood .
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PMC7759933
The obtained results showed that at lower initial density (3000 cells/spheroid) during 17-day cultivation, the HIF1α was downregulated compared to monolayer culture and the changes were significantly different from day 7 onwards with no further time-dependent deregulations (Figure 3C), which indicates that no excessive...
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PMC7171147
N = 2.
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PMC11764090
MPK3/6, negatively regulated by MKP1 , plays a key regulatory role during cold acclimation and may enhance freezing resistance and plant survival .
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PMC10788478
Overall, our findings clarify the therapeutic and prognostic significance of LGR6 overexpression induced by aberrant Wnt signaling in lung cancer.
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PMC11507371
Since cancer cells usually have higher ROS levels due to oncogenic stimulation, increased metabolism, and mitochondrial dysfunction, the antioxidant defence systems also play a crucial role in basal ROS levels .
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PMC11682172
Tumor cell areas were selected microscopically and a minimum content of 60% tumor tissue was taken as a threshold for RNA isolation.
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PMC11511922
Fig. S4AB16BL6 cancer cell line was incubated in the presence of different uptake inhibitors for 30 min and then labeled exo-N was added.
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PMC11295144
For assessing the activity of the presynaptic terminals, Cy5-labeled anti-synaptotagmin 1 luminal domain-specific antibody (1,50, 105311C5, Synaptic Systems) was added to the culture and incubated in the 37°C 5% CO2 humidified incubator for 30 min before fixation.
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PMC11585587
The statistical analysis was conducted using GraphPad Prism 9.0 software.
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PMC11474209
HCC15Human neuroblastoma cell line (SH-SY5Y)20–100 mg/mLOATPs, tau protein-Reduced cell viability, neurological degeneration, production of oxidative stress and disruption of AChENeurotoxic effects16HL77025 and 10 µMAKT1, p-AKT1-DNA damage, cell proliferation and migrationHepatotoxicity17Human colon cancer cell line (D...
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PMC9429973
CRS events were reported early in treatment and resolved in a median time of 2 d. Of the 23 evaluable pts, 11 pts received ASCT; prior to ASCT, the overall response rate (ORR) was 100% (82% [9/11] complete metabolic response [CMR]; 18% [2/11] partial metabolic response [PMR]).
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PMC11680982
HER2 subtypes include HER2 IHC 0 as HER2-0 and IHC score 1 and 2/ISH non-amplified as HER2-low.
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PMC9429973
To address these limitations, pirtobrutinib, a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed.
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PMC10998613
APC was excited using a 640 nm laser, filtered through 675/25 nm, and detected with FL4.
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PMC11394386
We analyzed PTEN expression levels in the HeLa cell line and observed a decrease compared to non-tumoral cell lines (Figure 5A).
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PMC11155445
Novel acyl thiourea (43) having two diethyl groups and one heterocyclic furanyl group was synthesized (Scheme 12) by Saeed et al. From single crystal XRD analysis it was found that the centrosymmetric dimer of respective thiourea was due to the strong intermolecular hydrogen bonding between N–H and O <svg xmlns="http:/...
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PMC9429973
Clinical secondary endpoints were ORR, CRR, OS, EFS and TTF.
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PMC11321678
Subgroup‐specific marker genes were revealed by gene expression profiles.
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PMC11791264
F, SETD7 KD inhibited the migration of A2780 cells determined by the Transwell assay.
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PMC11190238
These findings highlight the important role of the bivalent chromatin associated with the PRC2-related H3K27me3 modification during EMT.
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PMC11599565
This type of cancer is frequently diagnosed at very advanced stages for which therapeutic options are generally not curative.
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PMC11307990
Corresponding average fluorescence intensity of 786-0 cells in confocal images.
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PMC10329074
When the cells had reached a confluence of > 90% the next day, the scratch was made with a 10 µl pipette tip perpendicular to the horizontal line, and the medium was exchanged for a low-concentration serum medium.
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PMC9325715
Lately, big attention is paid to the production of so-called “functional food”.
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PMC9429973
Additionally, we are continuously recruiting new individuals into our study.
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PMC11519788
10 μl 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT, 5 mg/ml, M2128; Sigma, USA) was added to each well and removed after 3 h-incubation at 37℃.
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PMC11792766
The plates were incubated for 30 min at 25°C, and the reaction was stopped by adding 50 µL of 1 M acetic acid solution to each well.
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PMC11434983
Cytotoxicity and EGFR inhibition were evaluated in A431 cells overexpressing EGFR using MTT assays, Western blotting, and flow cytometry.
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PMC10538569
Consequently, GPI-scFv X5 transduced T cells do not neutralize HIV-1 replication in non-transduced CD4 T cells in coculture.
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