OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11448304	Radiotherapy (RT) is a primary treatment for NSCLC at all stages .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Radiotherapy", "(", "RT", ")", "is", "a", "primary", "treatment", "fo...
PMC11224020	Data were analyzed by Kruskal–Wallis test; P = 0.0021; **P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were...
PMC11727000	A limitation of this technique, however, relates to the radius of biotinylation which cannot distinguish direct binding proteins from those bound indirectly through larger protein complexes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213199	Table 2ClusterNodesEdgesNode IDs1242309HDAC1, Rpn2, prtp, Rpn13, Rpt3, Rpt4, CG15445, Rpt6, Rpt5, Prosbeta4, TppII, Rpn8, Plap, Rpt1, Rpn1, Rpn6, Rpn11, Rpn7, Rpn3, Usp 14, Rpt2, Lint-1, Rpn5, Rpn921355SP1029, Lsd-2, Chrac-14, achi, CG32803, CG1677, for, Stt3A, PPP4R2r, mip130, zf30C, Shmt, CG38473634Map 60, CG1737, CG...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	To assess the impact of the miRs on CLL cells survival during Ibrutinib treatment, we performed MTT assay in CLL cells after miR-181a/b silencing and Ibrutinib treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11269933	BiFC assay of CgERK1/2 and CgPK. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BiFC", "assay", "of", "CgERK1/2", "and", "CgPK", ".", "(" ] } ]
PMC7039683	Already, the human orthologs of four known elements of this GRN, Irf6, Grhl3, Klf17, and simple epithelium keratins, are implicated in risk for non-syndromic orofacial clefting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: With a response rate of 62% and an OS of 8.5 months, this combination may have benefit in HR RR MDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747885	While DNA ligase inhibitors have been widely studied, no human RNA ligase inhibitors are known.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "DNA", "ligase", "inhibitors", "have", "been",...
PMC11706776	The observed effects at the mRNA level are also translated to the protein level (Fig. 2D).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "observed", "effects", "at", "the", "...
PMC9219615	Cells were subsequently treated with the appropriate 24 h CC50 or 2xCC50 of Tpz-1 for 6 h (data shown) or 8 h (in Supplementary Materials).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545868	In the study by Hsiao, Y.C., et al., on human leukemia HL-60 cancer cells, 20–50 μM treatment induced apoptosis by increasing Bax, PARP cleavage, and caspase-9 and -3, inducing mitochondrial stress, and decreasing anti-apoptotic proteins such as Bcl-2 and Bid (Table 1) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Eculizumab has been the mainstay of treating patients with PNH since approval by both US Food and Drug Administration (FDA) and European Medicines Agency (EMA) in 2007.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11021472	As a control, a lentiviral vector with two non-targeting sgRNAs was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "control", ",", "a", "lentiviral", "vector", "with", "two",...
PMC8973085	Yellow solid (88%); mp: 230–233 °C. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yellow", "solid", "(", "88", "%", ")", ";", "mp", ":", "230–233...
PMC10938377	The compounds were added to the preincubated 96-well plates in 100 μL aliquots, and the plates were incubated for a further 72 h. MTT (20 μL, 5 mg mL in Dulbecco's phosphate buffered saline) was added to the cells, and the plates were incubated for a further 4 h. The culture medium was aspirated, and the purple formaza...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9111184	The scores scatter plot PC1 vs. PC2 shows a clear separation of cell groups along the PC1 and PC2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scores", "scatter", "plot"...
PMC7351993	The culture medium was replaced with appropriate fresh medium every day.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "culture", "medium", "was", "replaced", "with", "appropriate", "fresh", "medium", ...
PMC11594074	The SAH binding pocket was selected as the docking site, and the protocol was configured to perform 100 initial placements of each compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11519567	Discard the supernatant.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Discard", "the", "supernatant", "." ] } ]
PMC10213179	Cells were washed twice, and bound aptamers were analyzed using a Gallios flow cytometer and Kaluza Analysis 2.1 software (Beckman Coulter, Brea, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	S. Lee, Z. Li, E. Lim, E. Chiew, A. M. Tan, H. Ariffin, J. J. Yang, A. Yeoh St. Jude Children’s Research Hospital, MEMPHIS, United States of America; National University of Singapore; KK Women and Children’s Hospital, Singapore, Singapore; University of Malaya Medical Centre, Kuala Lumpur, Malaysia Background: Asparagi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779605	ABIN6955870, Abbexa LLC, Sugar Land, TX, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ABIN6955870", ",", "Abbexa", "LLC", ",", "Sugar", "Land", ",", "TX", ",", ...
PMC9429973	Kaplan-Meier curves were generated to provide visual summaries of survival and time-to-event data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan-Meier", "curves", "were", "generated", "to", "provide", "visual", "s...
PMC9429973	All p53+ patients had high DEK levels (TP53+/DEK); however, 16 of the TP53- patients had low DEK expression levels (TP53-/DEK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087766	Anti-sense guide RNAs pair with mRNA of expressed genes and activate Cas13a, which leads to cell dormancy and phage restriction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-sense", "guide", ...
PMC11629143	This provides evidence that CpG methylation of the CMV promoter can directly inhibit transgene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "provides", "evidence", "that", "CpG", "methylation", ...
PMC10577955	Following the manufacturer’s instructions, apoptotic cells’ surface exposure to phosphatidylserine was measured using an Annexin V-FITC apoptosis detection kit (Biovision, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739484	Interestingly, the wound healing assay results revealed a paradoxical effect on cell migration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "the", "wound", "healing", "assay", "results", ...
PMC9429973	4 patients died with 3 (4%) of these directly attributed to COVID19 infection and one due to myeloma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4", "patients", "...
PMC11774251	For binary group comparisons, we employed the two-tailed unpaired Student’s t-test when data met parametric assumptions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "binary", "group", "comparisons", ...
PMC10898159	The extracellular segment contains five immunoglobulin-like structural domains (D1-D5), of them D1-D2-D3 are stem cell factor (SCF) binding regions, and D4-D5 are important units for KIT dimer formation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	In the combined treatment, the cells were incubated first with compound 23 (for 3 h), followed by treatment with cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9118379	Distribution of 320 variant PSMs with support from de novo sequencing by 0–3 de novo sequencing tools.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Distribution", "of", "320", "variant", "PSMs", ...
PMC11377827	n = 5, biologically independent samples, mean ± sd, one-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", ",", "biologically", "independent", "samples", ","...
PMC11629461	Plasmid pCMV3‐DUOX2 (#HG18317‐UT, NCBI code NM_014080.4) was purchased from Sino Biological (Beijing, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plasmid", "pCMV3‐DUOX2", "("...
PMC8592717	PCA treatment attenuated brain oxidative stress through inhibition of brain mitochondrial dysfunction and hyperglycemia in rats with streptozotocin (STZ)-induced diabetes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "treatment", "attenuat...
PMC11742670	SMILES is a method for representing molecule structure by employing ASCII strings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SMILES", "is", "a", "method", "for", "representing", "molecule", "structure", "b...
PMC11301095	Th1 responses, involving macrophages and natural killer (NK) cells, are primarily responsible for direct pathogen attack.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Th1", "responses", ",", ...
PMC11795610	Myricetin exhibits multiple bioactivities, including anti-inflammatory, immunomodulatory, antibacterial, and analgesic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Myricetin", "exhibits", "multiple", "bioactivities", ",", "includ...
PMC9429973	Image: Summary/Conclusion: Our results highlight the lack of conformance to the current guidelines in various aspects of CML management, the excellent OS survival achievable with currently available TKIs and the importance of achieving CCyR for better OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11724582	For example, in a neuroblastoma mouse model, inhibition of the JAK2/STAT3 and MEK/ERK/1/2 pathways increased tumor sensitivity to etoposide, limited the carcinogenic activity of mesenchymal stromal cells, and inhibited tumor progression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11281366	Further validation of the miRNA-seq data using real-time qPCR revealed that miRNAs-21, -26a and -29a are indeed decreased in HIV-1-infected primary CD4 T cells as compared to uninfected cells (~6-, 2- and 4-fold less, p = 0.0003, p = 0.0484 and p = 0.0020, respectively) (Figure 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC6160470	The cells were collected and incubated at 2 × 10 cells in complete cell culture medium (see above) in the presence or absence of 0.5 µM Rhodamine 123 (Rho123; Sigma-Aldrich) in the dark at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The use of such instruments has been important for drug approval.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "such", "instruments", "has", "been", "important", "for", "drug", ...
PMC10958426	Paired Wilcoxon signed rank test was used to examine whether the differences were significant. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Paired", "Wilcoxon", "signed", "rank", "test", "was", "used...
PMC11400680	Cells and nuclei counts segmented per image. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "and", "nuclei", "counts", "segmented", "per", "image", ".", "(" ] } ]
PMC11746948	A375 cells were seeded at a density of 5000 cells per well in 96-well plates.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A375", "cells", "were", "seeded", "at", "a", "dens...
PMC11739696	This opens up significant opportunities for the development of nanoparticle-based therapies, which could potentially overcome the limitations of current treatments and provide more targeted, effective, and less toxic alternatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	These H3K27me3 blocks exhibit stronger gene expression repression and denser genomic interactions compared to individual peaks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "H3K27me3", "blocks", "exhibit", "stronger", "...
PMC9927933	For animal study, all procedures were approved by the Zhejiang University Committee on Use and Care of Animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "animal", "study", ",", ...
PMC9429973	Conventional cytogenetics was available in 118 (96%) patients and NGS-based somatic profiling in 115 (93.5%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conventional", "cytogen...
PMC10919056	The AUC of the RS prognostic model in the testing cohort for predicting 1-year, 3-year, and 5-year survival was 0.708, 0.696, and 0.741, respectively (Figure 5H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11463018	White solid, 57.2% yield.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "White", "solid", ",", "57.2", "%", "yield", "." ] } ]
PMC10243817	Based on our data, we identified a potentially novel MEX3B/TGFBR3 mRNA interaction that regulates TGF-β2 signaling and activation in human airway epithelial cells; specifically, we show that elevated MEX3B reduces TGF-βR3 and the associated TGF-β2 signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The TET2 gene encodes a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine and contributes to the epigenetic regulation of myelopoiesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10607604	At sampling, all patients were chemotherapy-naive, and were then treated with the carboplatin/paclitaxel combination as first-line systemic treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "sampling", ",", ...
PMC11472639	Specific lysis of RPMI-8226 cells cultured with PBMCs and HI-FCS mediated by daratumumab and in the presence of CD16 and CD32 blocking antibodies (ADCCHI-FCS + anti-CD16/CD32).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	55 karyotypic abnormalities were identified including monosomy 7 (29%), trisomy 8 (16%) and der (1;7) (9%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679326	This suggests that brain tumors can be differentially labeled according to their glycome profile features.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "brain", "tumors", "can", "be", ...
PMC9429973	Median time to treatment failure was 24 months on asciminib and 6 months on BOS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "time", "to", "treatment", "failure", "was", "24",...
PMC11507371	In contrast, we found a significantly higher expression of the antioxidative response gene HMOX1 and to a lesser extent, GPX1 in non-malignant HaCaT compared to A431 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC10114490	Enrichment plots (GSEA) are shown on the right.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enrichment", "plots", "(", "GSEA", ")", "are", "shown", "on", "the", "right", "." ] ...
PMC9429973	Fourth, when PBMCs were stimulated with BCC, spheroids developed proliferation center-like structures after 4 weeks of culture where T cells localized together with enrichment of Ki-67+ CLL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10723784	CBG has a weak affinity for cannabinoid CB1 and CB2 receptors and was suggested to exert its mechanism of action through TRP receptor channels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9739791	The NCs 10 were also found to generate singlet oxygen O2 when irradiated with 808 nm light.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NCs", "10", "were", "also", "found",...
PMC4270159	Treat cells for 10 min with 100 ng/ml FGF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treat", "cells", "for", "10", "min", "with", "100", "ng/ml", "FGF", "." ] } ]
PMC9429973	Adverse reactions occurred in 4.3% of the patients and SAEs were reported in 4 patients (5.8%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adverse", "reactions", "occu...
PMC11641532	To investigate the role of HSD3B7 in vivo, 769-P cells with HSD3B7 knockdown were subcutaneously injected into nude mice to establish a xenograft model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC9429973	Then we looked at the pre and post transfusion platelet levels for each group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "we", "looked", "at", "the", "pre", "and", "post", ...
PMC11470381	Measures cell polarity by examining spatial enrichment of Piezo1 and actin proteins within the front and rear halves of a moving Jurkat cell. •	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "token...
PMC9545474	Cells were incubated in a ThermoScientific HERAcell 150 incubator, and observed under a Nikon ECLIPSE TS100 Microscope. [(	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "incubated",...
PMC9429973	The non-specific initial presentation often leads to a late diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "non-specific", "initial", "presentation", "often", "leads", "to", "a", "late", "diagnosis...
PMC11451940	Prior to the ICP-MS analysis, the solutions were adjusted to suitable concentration with 4.5 mL of ultrapure water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "to", "the", "ICP-MS", ...
PMC11703992	The regulatory network of proteins and their transcriptional targets, as well as the likelihood of their interactions was inferred f by the algorithm ARACNe .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11323699	Significant reductions in CD47 expression were observed post NACT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", "reductions", "in", "CD47", "expression", "were", "observed", "post", "NACT", "." ] } ]
PMC8592717	When critically ill patients with severe community-acquired pneumonia were given XBJ, there was a significant improvement in the pneumonia severity index, primary end points, secondary clinical outcomes of mortality, and duration of mechanical ventilation and ICU stay .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11622247	In the single-stranded state, dyes in the thiazole orange family act as fluorescence quenchers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "single-stranded", "state", ",", "dyes", "in", ...
PMC5025404	From the initial 40 subclones, 20 subclones were selected on the basis of their specific productivity and overall productivity in the production batch.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8998437	Notably, CCR1 mRNA expression was abrogated in two type II BL cell lines, BL16 and Jijoye P79, which carried EBV strain Ag876 (type 2) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O"...
PMC11747949	First, we determined the secretion level of CCL2 and CCR2 expression patterns in 143B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "First", ",", "we", "determined", "the", "secr...
PMC10976516	In addition, the National Comprehensive Cancer Network has approved immunotherapy drugs such as nivolumab and nivolumab plus ipilimumab as a course of treatment for SCLC patients who have progressed after receiving one or more prior regimens or who have relapsed within 6 months of receiving initial therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11483468	The inhibition of QGY-7701 cell growth was measured by MTT assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inhibition", "of", "QGY-7701", "cell", "growth", "was", "measured", "by", "MTT...
PMC11310713	Furthermore, the Tb.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "Tb", "." ] } ]
PMC10470467	In the present study, we found that JAK1 was significantly associated with prognosis in ES patients, and genome-wide analysis also showed that JAK1 was significantly associated with inhibiting the cell cycle pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	The emergence of resistance to targeted therapies is often related to rewiring network connections, including pathway crosstalk and feedback loops.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "emergence", ...
PMC9429973	Relapsed/refractory (R/R) DLBCL can be cured with salvage treatments in roughly 40-50% of cases with standard available treatments which include high dose-chemotherapy plus autologous stem cell transplant (ASCT) in fit patients, and chimeric antigen receptor T-cells (CAR-T), permitted as third or subsequent line in pat...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549062	Additionally, disrupted endocytic motility influences the interplay between endosomes and lysosomes, which is crucial for controlling PDGFR‐β trafficking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "disrupt...
PMC10728200	The staining intensity and the proportion of positively stained cells were evaluated using Image J 1.53 software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "staining", "intensity", "and", "the", ...
PMC11593084	Furthermore, PDPN binds to hyaluronan receptor CD44 and matrix metalloproteinases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "PDPN", "binds", "to", "hyaluronan", "receptor", "CD44", "and", "m...
PMC11594806	CTLA-4 further promotes T-cell tolerance by inhibiting interleukin-17 (IL-17) production, encouraging the development of Foxp3+ and LAG3+ regulatory T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11279397	We first predicted the physicochemical properties of main phenols according to Lipinski’s rule of five (Ro5) using Molinspiration cheminformatics (https://molinspiration.com/, accessed on 8 November 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7342409	The transplantation model of human GIST resistant to imatinib in nude mice was identified and established.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transplantation", "model", "of", "human", "GIST...
PMC11730311	cAMP inhibition curves of hαCGRP8-37N25K-C20DA-γGlu and hαCGRP8-37A36S, N25K-C20DA-γGlu.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "cAMP", "inhibition", "curves", "of", "hαCGRP8", "-", "37N25K-C20DA-γGlu", "...
PMC8358006	P < 0.001, P < 0.01, P < 0.05, compared to control siRNA in Wilcoxon rank sum test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8427838	Construction and cloning of TMIGD1 into retroviral, pMSCV.puro vector was previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Construction", "and", "cloning", "of", "TMIGD1", "into", "retroviral", ",",...
PMC10197932	The untreated lymphocytes (basal ROS) and UT lymphocytes incubated with Dynabeads UT (UT+ Dynabeads) were grown-up for 24 hours and then analyzed by measuring DCFH-DA fluorescence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	tumor cells, MHC I, and transferred T cells, CD3 MHC I. k Transferred T cell numbers in tumoral and non-tumoral tissues in j upon ACT treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	In contrast, cord blood B cells derived from two different donors (“Donor 1” and “Donor 2”) resulted in long term EBV-infected B cell lines that can be maintained indefinitely on the feeder layer (but not off the feeder layer) when infected with the ΔEBNA2 EBV mutant, although the production of such lines is much less ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11617590	The high toxicity of chemotherapy also entails various side effects such as loss of appetite, pain, fatigue, to sleep disorders .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC11448304

Radiotherapy (RT) is a primary treatment for NSCLC at all stages .

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PMC11224020

Data were analyzed by Kruskal–Wallis test; **P = 0.0021; ****P < 0.0001.

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PMC11727000

A limitation of this technique, however, relates to the radius of biotinylation which cannot distinguish direct binding proteins from those bound indirectly through larger protein complexes .

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PMC10213199

Table 2ClusterNodesEdgesNode IDs1242309HDAC1, Rpn2, prtp, Rpn13, Rpt3, Rpt4, CG15445, Rpt6, Rpt5, Prosbeta4, TppII, Rpn8, Plap, Rpt1, Rpn1, Rpn6, Rpn11, Rpn7, Rpn3, Usp 14, Rpt2, Lint-1, Rpn5, Rpn921355SP1029, Lsd-2, Chrac-14, achi, CG32803, CG1677, for, Stt3A, PPP4R2r, mip130, zf30C, Shmt, CG38473634Map 60, CG1737, CG...

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PMC9429973

To assess the impact of the miRs on CLL cells survival during Ibrutinib treatment, we performed MTT assay in CLL cells after miR-181a/b silencing and Ibrutinib treatment.

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PMC11269933

BiFC assay of CgERK1/2 and CgPK. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BiFC", "assay", "of", "CgERK1/2", "and", "CgPK", ".", "(" ] } ]

PMC7039683

Already, the human orthologs of four known elements of this GRN, Irf6, Grhl3, Klf17, and simple epithelium keratins, are implicated in risk for non-syndromic orofacial clefting.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Image: Summary/Conclusion: With a response rate of 62% and an OS of 8.5 months, this combination may have benefit in HR RR MDS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11747885

While DNA ligase inhibitors have been widely studied, no human RNA ligase inhibitors are known.

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PMC11706776

The observed effects at the mRNA level are also translated to the protein level (Fig. 2D).Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "observed", "effects", "at", "the", "...

PMC9219615

Cells were subsequently treated with the appropriate 24 h CC50 or 2xCC50 of Tpz-1 for 6 h (data shown) or 8 h (in Supplementary Materials).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11545868

In the study by Hsiao, Y.C., et al., on human leukemia HL-60 cancer cells, 20–50 μM treatment induced apoptosis by increasing Bax, PARP cleavage, and caspase-9 and -3, inducing mitochondrial stress, and decreasing anti-apoptotic proteins such as Bcl-2 and Bid (Table 1) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Eculizumab has been the mainstay of treating patients with PNH since approval by both US Food and Drug Administration (FDA) and European Medicines Agency (EMA) in 2007.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11021472

As a control, a lentiviral vector with two non-targeting sgRNAs was used.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "control", ",", "a", "lentiviral", "vector", "with", "two",...

PMC8973085

Yellow solid (88%); mp: 230–233 °C. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yellow", "solid", "(", "88", "%", ")", ";", "mp", ":", "230–233...

PMC10938377

The compounds were added to the preincubated 96-well plates in 100 μL aliquots, and the plates were incubated for a further 72 h. MTT (20 μL, 5 mg mL in Dulbecco's phosphate buffered saline) was added to the cells, and the plates were incubated for a further 4 h. The culture medium was aspirated, and the purple formaza...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9111184

The scores scatter plot PC1 vs. PC2 shows a clear separation of cell groups along the PC1 and PC2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scores", "scatter", "plot"...

PMC7351993

The culture medium was replaced with appropriate fresh medium every day.

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PMC11594074

The SAH binding pocket was selected as the docking site, and the protocol was configured to perform 100 initial placements of each compound.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11519567

Discard the supernatant.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Discard", "the", "supernatant", "." ] } ]

PMC10213179

Cells were washed twice, and bound aptamers were analyzed using a Gallios flow cytometer and Kaluza Analysis 2.1 software (Beckman Coulter, Brea, CA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

S. Lee, Z. Li, E. Lim, E. Chiew, A. M. Tan, H. Ariffin, J. J. Yang, A. Yeoh St. Jude Children’s Research Hospital, MEMPHIS, United States of America; National University of Singapore; KK Women and Children’s Hospital, Singapore, Singapore; University of Malaya Medical Centre, Kuala Lumpur, Malaysia Background: Asparagi...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11779605

ABIN6955870, Abbexa LLC, Sugar Land, TX, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ABIN6955870", ",", "Abbexa", "LLC", ",", "Sugar", "Land", ",", "TX", ",", ...

PMC9429973

Kaplan-Meier curves were generated to provide visual summaries of survival and time-to-event data.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan-Meier", "curves", "were", "generated", "to", "provide", "visual", "s...

PMC9429973

All p53+ patients had high DEK levels (TP53+/DEK); however, 16 of the TP53- patients had low DEK expression levels (TP53-/DEK).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11087766

Anti-sense guide RNAs pair with mRNA of expressed genes and activate Cas13a, which leads to cell dormancy and phage restriction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-sense", "guide", ...

PMC11629143

This provides evidence that CpG methylation of the CMV promoter can directly inhibit transgene expression.

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PMC10577955

Following the manufacturer’s instructions, apoptotic cells’ surface exposure to phosphatidylserine was measured using an Annexin V-FITC apoptosis detection kit (Biovision, USA).

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PMC11739484

Interestingly, the wound healing assay results revealed a paradoxical effect on cell migration.

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PMC9429973

4 patients died with 3 (4%) of these directly attributed to COVID19 infection and one due to myeloma.

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PMC11774251

For binary group comparisons, we employed the two-tailed unpaired Student’s t-test when data met parametric assumptions.

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PMC10898159

The extracellular segment contains five immunoglobulin-like structural domains (D1-D5), of them D1-D2-D3 are stem cell factor (SCF) binding regions, and D4-D5 are important units for KIT dimer formation .

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PMC8345486

In the combined treatment, the cells were incubated first with compound 23 (for 3 h), followed by treatment with cisplatin.

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PMC9118379

Distribution of 320 variant PSMs with support from de novo sequencing by 0–3 de novo sequencing tools.

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PMC11377827

n = 5, biologically independent samples, mean ± sd, one-way ANOVA.

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PMC11629461

Plasmid pCMV3‐DUOX2 (#HG18317‐UT, NCBI code NM_014080.4) was purchased from Sino Biological (Beijing, China).

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PMC8592717

PCA treatment attenuated brain oxidative stress through inhibition of brain mitochondrial dysfunction and hyperglycemia in rats with streptozotocin (STZ)-induced diabetes .

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PMC11742670

SMILES is a method for representing molecule structure by employing ASCII strings.

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PMC11301095

Th1 responses, involving macrophages and natural killer (NK) cells, are primarily responsible for direct pathogen attack.

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PMC11795610

Myricetin exhibits multiple bioactivities, including anti-inflammatory, immunomodulatory, antibacterial, and analgesic effects.

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PMC9429973

Image: Summary/Conclusion: Our results highlight the lack of conformance to the current guidelines in various aspects of CML management, the excellent OS survival achievable with currently available TKIs and the importance of achieving CCyR for better OS.

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PMC11724582

For example, in a neuroblastoma mouse model, inhibition of the JAK2/STAT3 and MEK/ERK/1/2 pathways increased tumor sensitivity to etoposide, limited the carcinogenic activity of mesenchymal stromal cells, and inhibited tumor progression .

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PMC11281366

Further validation of the miRNA-seq data using real-time qPCR revealed that miRNAs-21, -26a and -29a are indeed decreased in HIV-1-infected primary CD4 T cells as compared to uninfected cells (~6-, 2- and 4-fold less, p = 0.0003, p = 0.0484 and p = 0.0020, respectively) (Figure 3A).

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PMC6160470

The cells were collected and incubated at 2 × 10 cells in complete cell culture medium (see above) in the presence or absence of 0.5 µM Rhodamine 123 (Rho123; Sigma-Aldrich) in the dark at 37 °C.

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PMC9429973

The use of such instruments has been important for drug approval.

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PMC10958426

Paired Wilcoxon signed rank test was used to examine whether the differences were significant. (

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PMC11400680

Cells and nuclei counts segmented per image. (

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PMC11746948

A375 cells were seeded at a density of 5000 cells per well in 96-well plates.

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PMC11739696

This opens up significant opportunities for the development of nanoparticle-based therapies, which could potentially overcome the limitations of current treatments and provide more targeted, effective, and less toxic alternatives.

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PMC11748335

These H3K27me3 blocks exhibit stronger gene expression repression and denser genomic interactions compared to individual peaks.

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PMC9927933

For animal study, all procedures were approved by the Zhejiang University Committee on Use and Care of Animals.

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PMC9429973

Conventional cytogenetics was available in 118 (96%) patients and NGS-based somatic profiling in 115 (93.5%).

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PMC10919056

The AUC of the RS prognostic model in the testing cohort for predicting 1-year, 3-year, and 5-year survival was 0.708, 0.696, and 0.741, respectively (Figure 5H).

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PMC11463018

White solid, 57.2% yield.

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PMC10243817

Based on our data, we identified a potentially novel MEX3B/TGFBR3 mRNA interaction that regulates TGF-β2 signaling and activation in human airway epithelial cells; specifically, we show that elevated MEX3B reduces TGF-βR3 and the associated TGF-β2 signaling.

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PMC9429973

The TET2 gene encodes a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine and contributes to the epigenetic regulation of myelopoiesis.

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PMC10607604

At sampling, all patients were chemotherapy-naive, and were then treated with the carboplatin/paclitaxel combination as first-line systemic treatment.

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PMC11472639

Specific lysis of RPMI-8226 cells cultured with PBMCs and HI-FCS mediated by daratumumab and in the presence of CD16 and CD32 blocking antibodies (ADCCHI-FCS + anti-CD16/CD32).

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PMC9429973

55 karyotypic abnormalities were identified including monosomy 7 (29%), trisomy 8 (16%) and der (1;7) (9%).

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PMC11679326

This suggests that brain tumors can be differentially labeled according to their glycome profile features.

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PMC9429973

Median time to treatment failure was 24 months on asciminib and 6 months on BOS.

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PMC11507371

In contrast, we found a significantly higher expression of the antioxidative response gene HMOX1 and to a lesser extent, GPX1 in non-malignant HaCaT compared to A431 cells.

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PMC10114490

Enrichment plots (GSEA) are shown on the right.

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PMC9429973

Fourth, when PBMCs were stimulated with BCC, spheroids developed proliferation center-like structures after 4 weeks of culture where T cells localized together with enrichment of Ki-67+ CLL cells.

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PMC10723784

CBG has a weak affinity for cannabinoid CB1 and CB2 receptors and was suggested to exert its mechanism of action through TRP receptor channels.

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PMC9739791

The NCs 10 were also found to generate singlet oxygen O2 when irradiated with 808 nm light.

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PMC4270159

Treat cells for 10 min with 100 ng/ml FGF.

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PMC9429973

Adverse reactions occurred in 4.3% of the patients and SAEs were reported in 4 patients (5.8%).

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PMC11641532

To investigate the role of HSD3B7 in vivo, 769-P cells with HSD3B7 knockdown were subcutaneously injected into nude mice to establish a xenograft model.

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PMC9429973

Then we looked at the pre and post transfusion platelet levels for each group.

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PMC11470381

Measures cell polarity by examining spatial enrichment of Piezo1 and actin proteins within the front and rear halves of a moving Jurkat cell. •

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PMC9545474

Cells were incubated in a ThermoScientific HERAcell 150 incubator, and observed under a Nikon ECLIPSE TS100 Microscope. [(

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PMC9429973

The non-specific initial presentation often leads to a late diagnosis.

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PMC11451940

Prior to the ICP-MS analysis, the solutions were adjusted to suitable concentration with 4.5 mL of ultrapure water.

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PMC11703992

The regulatory network of proteins and their transcriptional targets, as well as the likelihood of their interactions was inferred f by the algorithm ARACNe .

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PMC11323699

Significant reductions in CD47 expression were observed post NACT.

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PMC8592717

When critically ill patients with severe community-acquired pneumonia were given XBJ, there was a significant improvement in the pneumonia severity index, primary end points, secondary clinical outcomes of mortality, and duration of mechanical ventilation and ICU stay .

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PMC11622247

In the single-stranded state, dyes in the thiazole orange family act as fluorescence quenchers.

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PMC5025404

From the initial 40 subclones, 20 subclones were selected on the basis of their specific productivity and overall productivity in the production batch.

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PMC8998437

Notably, CCR1 mRNA expression was abrogated in two type II BL cell lines, BL16 and Jijoye P79, which carried EBV strain Ag876 (type 2) .

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PMC11747949

First, we determined the secretion level of CCL2 and CCR2 expression patterns in 143B cells.

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PMC10976516

In addition, the National Comprehensive Cancer Network has approved immunotherapy drugs such as nivolumab and nivolumab plus ipilimumab as a course of treatment for SCLC patients who have progressed after receiving one or more prior regimens or who have relapsed within 6 months of receiving initial therapy.

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PMC11483468

The inhibition of QGY-7701 cell growth was measured by MTT assay.

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PMC11310713

Furthermore, the Tb.

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PMC10470467

In the present study, we found that JAK1 was significantly associated with prognosis in ES patients, and genome-wide analysis also showed that JAK1 was significantly associated with inhibiting the cell cycle pathway.

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PMC11240448

The emergence of resistance to targeted therapies is often related to rewiring network connections, including pathway crosstalk and feedback loops.

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PMC9429973

Relapsed/refractory (R/R) DLBCL can be cured with salvage treatments in roughly 40-50% of cases with standard available treatments which include high dose-chemotherapy plus autologous stem cell transplant (ASCT) in fit patients, and chimeric antigen receptor T-cells (CAR-T), permitted as third or subsequent line in pat...

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PMC11549062

Additionally, disrupted endocytic motility influences the interplay between endosomes and lysosomes, which is crucial for controlling PDGFR‐β trafficking.

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PMC10728200

The staining intensity and the proportion of positively stained cells were evaluated using Image J 1.53 software.

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PMC11593084

Furthermore, PDPN binds to hyaluronan receptor CD44 and matrix metalloproteinases .

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PMC11594806

CTLA-4 further promotes T-cell tolerance by inhibiting interleukin-17 (IL-17) production, encouraging the development of Foxp3+ and LAG3+ regulatory T cells.

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PMC11279397

We first predicted the physicochemical properties of main phenols according to Lipinski’s rule of five (Ro5) using Molinspiration cheminformatics (https://molinspiration.com/, accessed on 8 November 2023).

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PMC7342409

The transplantation model of human GIST resistant to imatinib in nude mice was identified and established.

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PMC11730311

cAMP inhibition curves of hαCGRP8-37N25K-C20DA-γGlu and hαCGRP8-37A36S, N25K-C20DA-γGlu.

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PMC8358006

P < 0.001, **P < 0.01, **P < 0.05, compared to control siRNA in Wilcoxon rank sum test.

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PMC8427838

Construction and cloning of TMIGD1 into retroviral, pMSCV.puro vector was previously described .

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PMC10197932

The untreated lymphocytes (basal ROS) and UT lymphocytes incubated with Dynabeads UT (UT+ Dynabeads) were grown-up for 24 hours and then analyzed by measuring DCFH-DA fluorescence.

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PMC11787355

tumor cells, MHC I, and transferred T cells, CD3 MHC I. k Transferred T cell numbers in tumoral and non-tumoral tissues in j upon ACT treatment.

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PMC11045125

In contrast, cord blood B cells derived from two different donors (“Donor 1” and “Donor 2”) resulted in long term EBV-infected B cell lines that can be maintained indefinitely on the feeder layer (but not off the feeder layer) when infected with the ΔEBNA2 EBV mutant, although the production of such lines is much less ...

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PMC11617590

The high toxicity of chemotherapy also entails various side effects such as loss of appetite, pain, fatigue, to sleep disorders .

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