OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11248911	Calcd.	[ { "tags": [ "O", "O" ], "tokens": [ "Calcd", "." ] } ]
PMC11731614	Exploration of the role of EVs in diabetes, however, has primarily focused on adipose tissue and inter-organ communication (Ashrafizadeh et al., 2022, Sun, 2018, He, 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11237030	For membrane proteins, like AQP5, which contain hydrophobic transmembrane and extracellular domains, maintaining the native form as recombinant protein is more difficult.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11679326	Thus, lectin KSL from red alga Kappaphycus striatus, recognizing high mannose N-glycans, showed antiproliferative effects against colorectal adenocarcinoma HT29 cells, cervical adenocarcinoma Hela cells, breast cancer MCF-7 cells, human lung adenocarcinoma SK-LU-1 cells, and human gastric adenocarcinoma AGS cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC6643347	Cells harboring the viral genome represent a part of the infection reservoir that persists in the organism and may be retained for up to four years .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11765243	Signals mediated by class I PI3Ks are activated in T and B lymphocytes by many membrane receptors including antigen receptors and costimulatory molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Signals...
PMC11588008	Let it stand on the ice and precipitate with ethanol in a −20°C refrigerator for 10–30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Let", "it", "stand", "on", ...
PMC11670954	MLCK promotes the disruption of ZO-1 in Caco2 cells, which further deteriorates their condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MLCK", "promotes", "the", "disruption", "of", "ZO-1", ...
PMC11774112	Zeta potential of Co-PHRD at an N/P ratio of 10 determined by DLS. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zeta", "potential", "of", "Co-PHRD", "at", "an", "N/P", "ratio",...
PMC11727306	The measurement of the relative inhibition of the production of green fluorescence protein, as measured by light intensity, is a measure of the ability of abrin to bind and enter the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	May be we use more FFP due to covid situation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "May", "be", "we", "use", "more", "FFP", "due", "to", "covid", "situation", "." ] } ]
PMC11194678	Scale bar: 15 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "15", "μm", ".", "(" ] } ]
PMC9250505	NPB treatment of control transfected cells decreased phosphorylation of BADS99 compared to vehicle-treated CAOV2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "NPB", "treatment", "of", "control", "transfected", "cell...
PMC10329237	Up to now, the anti-fibrotic drug 5-methyl-1-phenyl-2-(1H)-pyridone or pirfenidone (PFD) has been proven by the US Food and Drug Administration (FDA) to treat IPF patients (6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	COS7 cells were cultured in glass bottom dishes and transfected as described above.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COS7", "cells", "were", "cultured", "in", "glass", "bottom", "dish...
PMC11575040	For instance, Tomic et al. reported that metformin exerted an antiproliferative effect on melanoma cells, with normal human melanocytes being resistant to this metformin-induced effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	For the measurement of G-Protein activity, cells were transfected with 1.5 µg of MOR wt and 1.5 µg of the BRET-activity sensor Go1-case (100 ng DNA/well).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This may be the mechanism responsible for the observed marrow suppression seen in these patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "may", "be", "the", "mechanism", "responsible", "for...
PMC10490530	Thereafter, the effects of the same modulators were tested in A2780pPIK3CA cells over-expressing the PIK3CA promoter driving FLuc2-tdT fusion reporter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thereafter", "...
PMC11317131	No synthesis or degradation of DNA occurs and no sequence homology is required for the donor DNA (21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "synthesis", "or", ...
PMC11721096	The resultant extract was evaporated, concentrated, and stored at −20 °C after three extraction cycles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resultant", "extract", "was", "...
PMC11629461	C–G, I–K) Fura‐2‐loaded NOX5‐CHO‐K1 (C) or miniSOG‐NOX5‐CHO‐K1 cells (D–G, I–K) were perifused, blue light (LED 450 nm, 85 mW/cm, 1.5 min) (C, E, G, J, K), DPI 10 μM (F, G) or Trolox‐C 300 μM (I, K) were applied (indicated by horizontal bars).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10958426	The tumor associated endothelial cell specific genes were enriched in extracellular matrix organization, blood vessel development, regulation of angiogenesis and regulation of cell-substrate adhesion (Figs. S3A and B), indicating endothelial cells in tumor played important role in promotion of angiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median age (range) was 73.0 (51–88) years, 55% were male, 80% were white, 8% had extramedullary disease, 59% were International Staging System stage II or III, 20% had amp1q, and 17% had high-risk cytogenetics (≥1 of: t(4;14), t(14;16), del17p).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540692	Similar results were published by Nakagawa et al. and Salimi et al. ; however, the latter reported pro-oxidative effects of NaBu in regard to breast cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7841067	ACT-1 cells were infected with sh-AKAP4 or si-NC for 24 h, respectively. (	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ACT-1", "cells", "were", "infected", "with", "sh-AKAP4", "or"...
PMC11769516	In the undifferentiated form, these cells have catecholaminergic characteristics and are morphologically recognized by similar neuroblasts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "undifferentiated", "form", ",", ...
PMC10728535	PCA plots of data summarized via batch correction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "plots", "of", "data", "summarized", "via", "batch", "correction", "." ] } ]
PMC11698348	It is currently unknown how this occurs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "currently", "unknown", "how", "this", "occurs", "." ] } ]
PMC11747949	7‐AAD negatives cells were used for the analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7‐AAD", "negatives", "cells", "were", "used", "for", "the", "analysis", "." ] } ]
PMC9429973	Family members were also examined.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Family", "members", "were", "also", "examined", "." ] } ]
PMC7642379	Red bar shows common 38 DE genes in the comparison of suspension cells against adherent cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "bar", "shows", "common", "38", "DE",...
PMC10443665	B. Samii, A. Jafarian, M. Rabbani, and B. Zolfaghari interpreted the data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B.", "Samii", ",", "A.", "Jafarian", ",", "M.", "Rabb...
PMC11745823	For further detailed methodologies and results, please consult the relevant documents provided .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "further", "detailed", "methodologies", "and", "results", ",", "pleas...
PMC10291556	The platinum quantity taken up by the cells was determined by inductively coupled plasma mass spectrometry (ICP–MS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "platinum", ...
PMC11143482	Water intake seems to be constant throughout the treatment period of mice in all groups except in mice inoculated with 3 × 10 of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11794847	NM-KO-190439) were purchased from Shanghai Model Organisms Center, Inc and 4–6-week-old mice were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NM-KO-190439", ")", "were", "purchased", "from", "Shan...
PMC8481254	Diabetes is an important risk factor for liver cancer, but its mechanism is unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Diabetes", "is", "an", "important", "risk", "factor", "for"...
PMC11746942	To further investigate the role of keratinocyte-specific S1PR3 in psoriasis progression, we generated keratinocyte-specific S1PR3knockdown mice through intradermal injection of adeno-associated virus serotype 9-shS1PR3 with the K14 promoter (K14-AAV9-shS1PR3) (Fig. 3E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11463018	The fused molecules were confirmed to retain the essential interactions with both proteins in enzymatic assay to exert desired biological functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fused", "m...
PMC11577421	CHO-K1 and pgsA-745 cells were cultured in Ham’s F-12 culture medium containing 10% FBS and 1% penicillin/streptomycin at 37 °C in a humidified 5% CO2 atmosphere.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11377827	Several DUBs have been linked to reversing HIF-α stabilisation, including USP7, USP8, USP20, USP25, USP29, USP33, BAP1 and UCHL1 (Bononi et al, 2023; Gao et al, 2021; Goto et al, 2015; Li et al, 2005; Nelson et al, 2022; Troilo et al, 2014; Wu et al, 2016; Zhang et al, 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10587429	By a rotating action using a 26 Gauge needle, bore a hole through the notch in the knee into the tibia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "a", ...
PMC11803918	Other than permanent destruction, this method only generated temporary ice crystals in the freezing condition to disrupt the lipid bilayer structure of γδ-T exosomes for the fusion of the disrupted bilayer (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9430052	The median Tmax was 14d (range 14-14d), median peak copy number (Cmax) in peripheral blood was 89,120 (range 55,222-90,174) copies/mgDNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193813	Values for natural gas supply, adjusted for the C2H6 and H2 composition of the St. Charles fuel, were used to calculate the fuel carbon supply rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739670	One‐way ANOVA with correction for multiple comparisons was used with p‐value denoted by p < 0.05, p < 0.01, p < 0.001 and **p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	If the error reduction as compared to the null model was not significantly worse, the new network adjustment was upheld otherwise the next best solution was simulated and tested. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640247	Additional downstream effectors not assessed in this study may also play a role in RAC3-R66W signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "downstream", "effectors", "not", "assessed", ...
PMC11726848	We have shown that the main mechanism underlying the effects of LDR and HDR irradiations is the cell cycle arrest after HDR irradiation and the absence of such arrest after LDR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350	G At sacrifice splenic T cells were surface stained for CD8 and hCD34 followed by intracellular staining for INFγ, perforin and granzyme B and analyzed by FACS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	We adopted a transcription factor-mediated differentiation protocol to differentiate human iPS cells into cortical neurons (iNeurons).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "adopted", "a", "transcription", ...
PMC11551844	For blank, the medium (50 μL) was added to the wells containing cells (50 μL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "blank", ",", "t...
PMC10976516	Since it is one of the major causes of cancer-related deaths globally, swift progress in developing new and better therapies is of crucial importance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Y. Li, X. Lyu Central Lab, Henan Cancer Hospital, Zhengzhou, China Background: Acute myeloid leukemia (AML) is a malignancy that originates from myeloid hematopoietic stem/progenitor cells in the bone marrow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674891	Currently, LUAD is the leading cause of cancer-related deaths globally, with metastasis detected in nearly 50% of cases at the time of diagnosis, contributing to the high mortality rate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490	For the detection of antibodies against inactivated TMUV, a 96-well ELISA plate was coated with inactivated TMUV (3.2 μg/well) in a coating buffer (pH 9.6) overnight at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087055	In contrast, the Vg1/COS implanted embryos under mitotic arrest condition exhibited the polonaise movements predominantly at the induction point of the secondary axis with disrupted authentic cell flow at the site of the authentic midline axis (n=3, Figure 4H–H”’, J–J”’ and L–L”’, and Video 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592837	Medium supernatants of culture samples were centrifuged at 16,000× g for 10 min at 4°C, aliquots were transferred to 1.5 mL tubes and cfDNA concentration was determined using Qubit™ dsDNA HS Assay Kit and Qubit™ 3.0 Fluorometer (ThermoFisher, Fisher Scientific, Invitrogen, Eugene, OR, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11063646	To this, we observed an enhancement in the cytotoxicity threshold of andrographolide when formulated as an emulgel ANG 12, as compared to pure andrographolide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11129910	By gene expression analysis, the TNBC were classified into six subtypes: basal-like (BL-1 and BL-2), immunomodulatory (IM), mesenchymal-like (M), mesenchymal stem-like (MSL), and androgen receptor type (AR) , each subtype with different molecular and clinical characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793	The nanoparticles had hydrodynamic diameters of approximately 30 nm and were functionalized with polyethylenimine (Au-PEI@NIST) and carboxylated polyethylene glycol (Au-PEG-COOH@NIST), which resulted in cationic and anionic charges, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615101	The bar graph represents the densitometric values of WB for STX3, upregulated as we increase the dose of α-Taxilin. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bar", "gra...
PMC10170482	Subsequently, levels of pyruvate (C) and lactate (D) were determined using the pyruvate fluorescence assay or lactate fluorescence assay, respectively (both from Sigma Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10900886	Statistical analysis was performed with unpaired t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed", "with", "unpaired", "t-test", "." ] } ]
PMC11127909	Meanwhile, we isolated their mitochondria and assessed EFHD1 expression at the mitochondrial level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", "we", "isolated", "their", "mitochondria", "and", ...
PMC9454178	H, I qRT–PCR and immunoblotting analyses showed that OSR1 knockdown significantly inhibited c-KIT mRNA and protein expression in GIST-T1 and GIST-882 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "...
PMC11367146	Sucheesmita Padhee: Writing – original draft, Investigation, Data curation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sucheesmita", "Padhee", ":", "Writing", "–", "original", "draft", ",", "Investig...
PMC11682525	To induce a hypoxic environment, hHFSCs and SH-SY5Y cells were initially seeded in 4-well plates and subsequently placed within a modular incubator chamber (MIC-101, Billups-Rothenberg).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11569208	Multi-step and single-step growth curves of 786-0 infected with VSV∆51-NTC or VSV∆51-shACP2 (MOI 0.01 or 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multi-step", "and", "single-...
PMC9429973	Image: Summary/Conclusion: In the notoriously difficult-to-treat RS patient population, ven-based combination regimens achieve high response rates, including some with prolonged duration, particularly with the use of R-CHOP + ven.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9688728	The p-value of this pathway is 3.22 × 10, and its match status is 17/48.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "p-value", "of", "this", "pathway", "is", ...
PMC10919056	In this study, LASSO and Cox regression models were developed for 21 GJPs to identify genes with independent prognostic effects, and the relationships between GRPS and tumor grade, tumor stage and survival status of patients were further explored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	More broadly, the dependence of interactions with genomic separation was correctly captured by the model (Supplemental Fig. S2C), and we found good correlation with experiments using several different metrics (e.g., a Pearson's correlation of 0.7 was observed for the directionality index profile) (see Supplemental Fig....	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	PCC, Pearson correlation coefficient.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCC", ",", "Pearson", "correlation", "coefficient", "." ] } ]
PMC4369959	Thus, ginger can be considered as one of the promising chemotherapeutics agents for the treatment of cholangiocarcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "ginger", "can", "be", ...
PMC11544122	To confirm the interaction in cells, we examined SNX9 binding to CXCR4 by bioluminescence resonance energy transfer (BRET).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "confirm", "...
PMC8873393	In fact, it has been proved that the synthesis of nascent RNAs ensures maximal transcription-driven repair throughout expressed genes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "it"...
PMC11342785	GFP-TPPP variants droplet number in total five images, respectively; TPPP FL, n = 107; TPPP -Ccore(45–219), n = 92; TPPP-Ncore(1–166), n = 73; TPPP(45–206), n = 53; TPPP(45–196), n = 60; TPPP(20–166), n = 89; TPPP(45–186), n = 90; TPPP(45–176), n = 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10344560	Removal and reinsertion of the PD catheter were done simultaneously based on consideration of clinically stable condition, adequate PD, and no sign of systemic infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The primary objectives include assessment of dose-limiting toxicities and identification of the recommended dose for further investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "objectives", "include", "assess...
PMC9910796	A quantitative analysis of the different types of virus particles (immature, mature and defective) detected in viral factories (Fig 2K, left panel) and budding areas (Fig 2K, right panel) showed, as expected, a significant increase in the proportion of mature particles (from ~30 to ~70%) at the exit sites in control in...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	One hundred and forty-two peripheral blood (PB) samples were collected at days +7, +14, +30, +90 (40, 39, 40 and 23 samples, respectively) after infusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806818	At present, the methods for isolating exosomes mainly rely on differences in particle size or specific surface markers to extract exosomes, including ultracentrifugation, size exclusion chromatography, and microfluidics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	CTX130 is modified with CRISPR/Cas9-editing to eliminate expression of: 1) T-cell receptor (TCR) by TCR alpha constant disruption, 2) major histocompatibility complex class I expression by β2-microglobulin disruption, and 3) CD70 to mitigate fratricide and enhance performance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10631132	RNA concentration was measured using a NanoDrop (ThermoFisher, Waltham, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "concentration", "was", "measured", "using", "a", "NanoDrop", ...
PMC10882807	Cell proliferation was determined by CCK-8 assays in BEL-7404, HCCLM3 and SK-Hep1 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Cell", "proliferation", "was", "determined", ...
PMC9429973	Image: Summary/Conclusion: We observed a high CI of cardiac events (58.5%) in a real-world series of patients undergoing AML therapy, associated with significant mortality due to cardiotoxicity (3.6%), and decreased OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11575040	If these miR-1270-target gene pairs play critical role in melanoma, we would expect a negative correlation between miR-1270 and its target gene expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11422497	Intriguingly, a single circRNA can regulate multiple miRNAs, and reciprocally, the same miRNAs can regulate multiple mRNA genes, forming an extensive circRNA-miRNA-mRNA competitive network that significantly influences tumor development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	This is a scale-free model that mimicks the gene duplication and divergence processes in biology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "a", "scale-free", "model", "that", "mimicks",...
PMC11484188	A total of 5x10 MM cells (U266 and RPMI-8226) were seeded in a 6-well plate, cultured for 24 h at 37˚C and were then transfected with Scr or miR-1343-3p inhibitor as aforementioned.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Secondary endpoints will evaluate the effect of mitapivat on Hb, hemolysis, erythropoiesis, iron metabolism and overload, safety, quality of life, and pharmacokinetics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	Knockdown of EFHD1 in 143BR cells reduced tumor volume and tumor weight compared with 143BR-shV cells.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Knockdown", "of", "EFHD1", "in", "143BR", ...
PMC11634794	By employing the single sample gene enrichment analysis (ssGSEA) algorithm, we conducted a quantitative assessment of the relative levels of tumor invasion for 24 immune cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754291	Cells were exposed to blue light (457 nm, 10 mW/cm, 15 J/cm; 50 mW/cm, 50 J/cm) or UVA light (385 nm, 15 mW/cm, 20 J/cm) on days 1, 3, and 7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055443	The oligonucleotide sequences of primers used for real time PCR (11, 12) are reported in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "oligonucleotide", "se...
PMC11745600	The transplanted cells persisted for at least 15 wk, and they tested positive for human C-peptide or human glucagon (Figure 5I and J; Figure S6 (SDC, http://links.lww.com/TP/D122).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	Scale bar, 25 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "25", "μm", "." ] } ]
PMC8992508	Triazole derivatives In search for more stable analogues, Peña-Solórzano et al. prepared a series of tariquidar analogues with chalcone and ketone moieties, according to a bioisosteric approach [Figure 16].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11248911

Calcd.

[ { "tags": [ "O", "O" ], "tokens": [ "Calcd", "." ] } ]

PMC11731614

Exploration of the role of EVs in diabetes, however, has primarily focused on adipose tissue and inter-organ communication (Ashrafizadeh et al., 2022, Sun, 2018, He, 2020).

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PMC11237030

For membrane proteins, like AQP5, which contain hydrophobic transmembrane and extracellular domains, maintaining the native form as recombinant protein is more difficult.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11679326

Thus, lectin KSL from red alga Kappaphycus striatus, recognizing high mannose N-glycans, showed antiproliferative effects against colorectal adenocarcinoma HT29 cells, cervical adenocarcinoma Hela cells, breast cancer MCF-7 cells, human lung adenocarcinoma SK-LU-1 cells, and human gastric adenocarcinoma AGS cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...

PMC6643347

Cells harboring the viral genome represent a part of the infection reservoir that persists in the organism and may be retained for up to four years .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11765243

Signals mediated by class I PI3Ks are activated in T and B lymphocytes by many membrane receptors including antigen receptors and costimulatory molecules.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Signals...

PMC11588008

Let it stand on the ice and precipitate with ethanol in a −20°C refrigerator for 10–30 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Let", "it", "stand", "on", ...

PMC11670954

MLCK promotes the disruption of ZO-1 in Caco2 cells, which further deteriorates their condition.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MLCK", "promotes", "the", "disruption", "of", "ZO-1", ...

PMC11774112

Zeta potential of Co-PHRD at an N/P ratio of 10 determined by DLS. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zeta", "potential", "of", "Co-PHRD", "at", "an", "N/P", "ratio",...

PMC11727306

The measurement of the relative inhibition of the production of green fluorescence protein, as measured by light intensity, is a measure of the ability of abrin to bind and enter the cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

May be we use more FFP due to covid situation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "May", "be", "we", "use", "more", "FFP", "due", "to", "covid", "situation", "." ] } ]

PMC11194678

Scale bar: 15 μm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "15", "μm", ".", "(" ] } ]

PMC9250505

NPB treatment of control transfected cells decreased phosphorylation of BADS99 compared to vehicle-treated CAOV2 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "NPB", "treatment", "of", "control", "transfected", "cell...

PMC10329237

Up to now, the anti-fibrotic drug 5-methyl-1-phenyl-2-(1H)-pyridone or pirfenidone (PFD) has been proven by the US Food and Drug Administration (FDA) to treat IPF patients (6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11194678

COS7 cells were cultured in glass bottom dishes and transfected as described above.

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COS7", "cells", "were", "cultured", "in", "glass", "bottom", "dish...

PMC11575040

For instance, Tomic et al. reported that metformin exerted an antiproliferative effect on melanoma cells, with normal human melanocytes being resistant to this metformin-induced effect.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11806106

For the measurement of G-Protein activity, cells were transfected with 1.5 µg of MOR wt and 1.5 µg of the BRET-activity sensor Go1-case (100 ng DNA/well).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

This may be the mechanism responsible for the observed marrow suppression seen in these patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "may", "be", "the", "mechanism", "responsible", "for...

PMC10490530

Thereafter, the effects of the same modulators were tested in A2780pPIK3CA cells over-expressing the PIK3CA promoter driving FLuc2-tdT fusion reporter.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thereafter", "...

PMC11317131

No synthesis or degradation of DNA occurs and no sequence homology is required for the donor DNA (21).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "synthesis", "or", ...

PMC11721096

The resultant extract was evaporated, concentrated, and stored at −20 °C after three extraction cycles.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resultant", "extract", "was", "...

PMC11629461

C–G, I–K) Fura‐2‐loaded NOX5‐CHO‐K1 (C) or miniSOG‐NOX5‐CHO‐K1 cells (D–G, I–K) were perifused, blue light (LED 450 nm, 85 mW/cm, 1.5 min) (C, E, G, J, K), DPI 10 μM (F, G) or Trolox‐C 300 μM (I, K) were applied (indicated by horizontal bars).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10958426

The tumor associated endothelial cell specific genes were enriched in extracellular matrix organization, blood vessel development, regulation of angiogenesis and regulation of cell-substrate adhesion (Figs. S3A and B), indicating endothelial cells in tumor played important role in promotion of angiogenesis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Median age (range) was 73.0 (51–88) years, 55% were male, 80% were white, 8% had extramedullary disease, 59% were International Staging System stage II or III, 20% had amp1q, and 17% had high-risk cytogenetics (≥1 of: t(4;14), t(14;16), del17p).

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PMC8540692

Similar results were published by Nakagawa et al. and Salimi et al. ; however, the latter reported pro-oxidative effects of NaBu in regard to breast cancer cells.

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PMC7841067

ACT-1 cells were infected with sh-AKAP4 or si-NC for 24 h, respectively. (

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PMC11769516

In the undifferentiated form, these cells have catecholaminergic characteristics and are morphologically recognized by similar neuroblasts .

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PMC10728535

PCA plots of data summarized via batch correction.

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PMC11698348

It is currently unknown how this occurs.

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PMC11747949

7‐AAD negatives cells were used for the analysis.

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PMC9429973

Family members were also examined.

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PMC7642379

Red bar shows common 38 DE genes in the comparison of suspension cells against adherent cells. (

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PMC10443665

B. Samii, A. Jafarian, M. Rabbani, and B. Zolfaghari interpreted the data.

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PMC11745823

For further detailed methodologies and results, please consult the relevant documents provided .

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PMC10291556

The platinum quantity taken up by the cells was determined by inductively coupled plasma mass spectrometry (ICP–MS).

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PMC11143482

Water intake seems to be constant throughout the treatment period of mice in all groups except in mice inoculated with 3 × 10 of cancer cells.

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PMC11794847

NM-KO-190439) were purchased from Shanghai Model Organisms Center, Inc and 4–6-week-old mice were used.

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PMC8481254

Diabetes is an important risk factor for liver cancer, but its mechanism is unknown.

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PMC11746942

To further investigate the role of keratinocyte-specific S1PR3 in psoriasis progression, we generated keratinocyte-specific S1PR3knockdown mice through intradermal injection of adeno-associated virus serotype 9-shS1PR3 with the K14 promoter (K14-AAV9-shS1PR3) (Fig. 3E).

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PMC11463018

The fused molecules were confirmed to retain the essential interactions with both proteins in enzymatic assay to exert desired biological functions.

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PMC11577421

CHO-K1 and pgsA-745 cells were cultured in Ham’s F-12 culture medium containing 10% FBS and 1% penicillin/streptomycin at 37 °C in a humidified 5% CO2 atmosphere.

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PMC11377827

Several DUBs have been linked to reversing HIF-α stabilisation, including USP7, USP8, USP20, USP25, USP29, USP33, BAP1 and UCHL1 (Bononi et al, 2023; Gao et al, 2021; Goto et al, 2015; Li et al, 2005; Nelson et al, 2022; Troilo et al, 2014; Wu et al, 2016; Zhang et al, 2022).

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PMC10587429

By a rotating action using a 26 Gauge needle, bore a hole through the notch in the knee into the tibia.

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PMC11803918

Other than permanent destruction, this method only generated temporary ice crystals in the freezing condition to disrupt the lipid bilayer structure of γδ-T exosomes for the fusion of the disrupted bilayer (Figure 1).

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PMC9430052

The median Tmax was 14d (range 14-14d), median peak copy number (Cmax) in peripheral blood was 89,120 (range 55,222-90,174) copies/mgDNA.

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PMC8193813

Values for natural gas supply, adjusted for the C2H6 and H2 composition of the St. Charles fuel, were used to calculate the fuel carbon supply rate.

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PMC11739670

One‐way ANOVA with correction for multiple comparisons was used with p‐value denoted by *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.

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PMC11469524

If the error reduction as compared to the null model was not significantly worse, the new network adjustment was upheld otherwise the next best solution was simulated and tested. (

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PMC11640247

Additional downstream effectors not assessed in this study may also play a role in RAC3-R66W signaling.

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PMC11726848

We have shown that the main mechanism underlying the effects of LDR and HDR irradiations is the cell cycle arrest after HDR irradiation and the absence of such arrest after LDR.

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PMC11401350

G At sacrifice splenic T cells were surface stained for CD8 and hCD34 followed by intracellular staining for INFγ, perforin and granzyme B and analyzed by FACS.

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PMC11001582

We adopted a transcription factor-mediated differentiation protocol to differentiate human iPS cells into cortical neurons (iNeurons).

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PMC11551844

For blank, the medium (50 μL) was added to the wells containing cells (50 μL).

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PMC10976516

Since it is one of the major causes of cancer-related deaths globally, swift progress in developing new and better therapies is of crucial importance.

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PMC9429973

Y. Li, X. Lyu Central Lab, Henan Cancer Hospital, Zhengzhou, China Background: Acute myeloid leukemia (AML) is a malignancy that originates from myeloid hematopoietic stem/progenitor cells in the bone marrow.

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PMC11674891

Currently, LUAD is the leading cause of cancer-related deaths globally, with metastasis detected in nearly 50% of cases at the time of diagnosis, contributing to the high mortality rate .

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PMC11291490

For the detection of antibodies against inactivated TMUV, a 96-well ELISA plate was coated with inactivated TMUV (3.2 μg/well) in a coating buffer (pH 9.6) overnight at 4 °C.

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PMC11087055

In contrast, the Vg1/COS implanted embryos under mitotic arrest condition exhibited the polonaise movements predominantly at the induction point of the secondary axis with disrupted authentic cell flow at the site of the authentic midline axis (n=3, Figure 4H–H”’, J–J”’ and L–L”’, and Video 4).

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PMC11592837

Medium supernatants of culture samples were centrifuged at 16,000× g for 10 min at 4°C, aliquots were transferred to 1.5 mL tubes and cfDNA concentration was determined using Qubit™ dsDNA HS Assay Kit and Qubit™ 3.0 Fluorometer (ThermoFisher, Fisher Scientific, Invitrogen, Eugene, OR, USA).

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PMC11063646

To this, we observed an enhancement in the cytotoxicity threshold of andrographolide when formulated as an emulgel ANG 12, as compared to pure andrographolide.

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PMC11129910

By gene expression analysis, the TNBC were classified into six subtypes: basal-like (BL-1 and BL-2), immunomodulatory (IM), mesenchymal-like (M), mesenchymal stem-like (MSL), and androgen receptor type (AR) , each subtype with different molecular and clinical characteristics.

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PMC11767793

The nanoparticles had hydrodynamic diameters of approximately 30 nm and were functionalized with polyethylenimine (Au-PEI@NIST) and carboxylated polyethylene glycol (Au-PEG-COOH@NIST), which resulted in cationic and anionic charges, respectively.

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PMC11615101

The bar graph represents the densitometric values of WB for STX3, upregulated as we increase the dose of α-Taxilin. (

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PMC10170482

Subsequently, levels of pyruvate (C) and lactate (D) were determined using the pyruvate fluorescence assay or lactate fluorescence assay, respectively (both from Sigma Aldrich).

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PMC10900886

Statistical analysis was performed with unpaired t-test.

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PMC11127909

Meanwhile, we isolated their mitochondria and assessed EFHD1 expression at the mitochondrial level.

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PMC9454178

H, I qRT–PCR and immunoblotting analyses showed that OSR1 knockdown significantly inhibited c-KIT mRNA and protein expression in GIST-T1 and GIST-882 cells.

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PMC11367146

Sucheesmita Padhee: Writing – original draft, Investigation, Data curation.

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PMC11682525

To induce a hypoxic environment, hHFSCs and SH-SY5Y cells were initially seeded in 4-well plates and subsequently placed within a modular incubator chamber (MIC-101, Billups-Rothenberg).

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PMC11569208

Multi-step and single-step growth curves of 786-0 infected with VSV∆51-NTC or VSV∆51-shACP2 (MOI 0.01 or 1).

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PMC9429973

Image: Summary/Conclusion: In the notoriously difficult-to-treat RS patient population, ven-based combination regimens achieve high response rates, including some with prolonged duration, particularly with the use of R-CHOP + ven.

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PMC9688728

The p-value of this pathway is 3.22 × 10, and its match status is 17/48.

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PMC10919056

In this study, LASSO and Cox regression models were developed for 21 GJPs to identify genes with independent prognostic effects, and the relationships between GRPS and tumor grade, tumor stage and survival status of patients were further explored.

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PMC9341513

More broadly, the dependence of interactions with genomic separation was correctly captured by the model (Supplemental Fig. S2C), and we found good correlation with experiments using several different metrics (e.g., a Pearson's correlation of 0.7 was observed for the directionality index profile) (see Supplemental Fig....

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PMC4443654

PCC, Pearson correlation coefficient.

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PMC4369959

Thus, ginger can be considered as one of the promising chemotherapeutics agents for the treatment of cholangiocarcinoma.

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PMC11544122

To confirm the interaction in cells, we examined SNX9 binding to CXCR4 by bioluminescence resonance energy transfer (BRET).

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PMC8873393

In fact, it has been proved that the synthesis of nascent RNAs ensures maximal transcription-driven repair throughout expressed genes .

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PMC11342785

GFP-TPPP variants droplet number in total five images, respectively; TPPP FL, n = 107; TPPP -Ccore(45–219), n = 92; TPPP-Ncore(1–166), n = 73; TPPP(45–206), n = 53; TPPP(45–196), n = 60; TPPP(20–166), n = 89; TPPP(45–186), n = 90; TPPP(45–176), n = 4.

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PMC10344560

Removal and reinsertion of the PD catheter were done simultaneously based on consideration of clinically stable condition, adequate PD, and no sign of systemic infection.

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PMC9429973

The primary objectives include assessment of dose-limiting toxicities and identification of the recommended dose for further investigation.

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PMC9910796

A quantitative analysis of the different types of virus particles (immature, mature and defective) detected in viral factories (Fig 2K, left panel) and budding areas (Fig 2K, right panel) showed, as expected, a significant increase in the proportion of mature particles (from ~30 to ~70%) at the exit sites in control in...

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PMC9429973

One hundred and forty-two peripheral blood (PB) samples were collected at days +7, +14, +30, +90 (40, 39, 40 and 23 samples, respectively) after infusion.

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PMC11806818

At present, the methods for isolating exosomes mainly rely on differences in particle size or specific surface markers to extract exosomes, including ultracentrifugation, size exclusion chromatography, and microfluidics.

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PMC9429973

CTX130 is modified with CRISPR/Cas9-editing to eliminate expression of: 1) T-cell receptor (TCR) by TCR alpha constant disruption, 2) major histocompatibility complex class I expression by β2-microglobulin disruption, and 3) CD70 to mitigate fratricide and enhance performance.

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PMC10631132

RNA concentration was measured using a NanoDrop (ThermoFisher, Waltham, USA).

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PMC10882807

Cell proliferation was determined by CCK-8 assays in BEL-7404, HCCLM3 and SK-Hep1 cells. (

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PMC9429973

Image: Summary/Conclusion: We observed a high CI of cardiac events (58.5%) in a real-world series of patients undergoing AML therapy, associated with significant mortality due to cardiotoxicity (3.6%), and decreased OS.

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PMC11575040

If these miR-1270-target gene pairs play critical role in melanoma, we would expect a negative correlation between miR-1270 and its target gene expression .

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PMC11422497

Intriguingly, a single circRNA can regulate multiple miRNAs, and reciprocally, the same miRNAs can regulate multiple mRNA genes, forming an extensive circRNA-miRNA-mRNA competitive network that significantly influences tumor development.

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PMC6379402

This is a scale-free model that mimicks the gene duplication and divergence processes in biology.

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PMC11484188

A total of 5x10 MM cells (U266 and RPMI-8226) were seeded in a 6-well plate, cultured for 24 h at 37˚C and were then transfected with Scr or miR-1343-3p inhibitor as aforementioned.

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PMC9429973

Secondary endpoints will evaluate the effect of mitapivat on Hb, hemolysis, erythropoiesis, iron metabolism and overload, safety, quality of life, and pharmacokinetics.

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PMC11127909

Knockdown of EFHD1 in 143BR cells reduced tumor volume and tumor weight compared with 143BR-shV cells.

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PMC11634794

By employing the single sample gene enrichment analysis (ssGSEA) algorithm, we conducted a quantitative assessment of the relative levels of tumor invasion for 24 immune cell types.

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PMC11754291

Cells were exposed to blue light (457 nm, 10 mW/cm, 15 J/cm; 50 mW/cm, 50 J/cm) or UVA light (385 nm, 15 mW/cm, 20 J/cm) on days 1, 3, and 7.

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PMC11055443

The oligonucleotide sequences of primers used for real time PCR (11, 12) are reported in Table 1.

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PMC11745600

The transplanted cells persisted for at least 15 wk, and they tested positive for human C-peptide or human glucagon (Figure 5I and J; Figure S6 (SDC, http://links.lww.com/TP/D122).

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PMC11194678

Scale bar, 25 μm.

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PMC8992508

Triazole derivatives In search for more stable analogues, Peña-Solórzano et al. prepared a series of tariquidar analogues with chalcone and ketone moieties, according to a bioisosteric approach [Figure 16].

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