OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11742864	The ω-3 LCPUFAs, primarily consisting of eicosapentaenoic acid and docosahexaenoic acid, were found to modify inflammatory tumor microenvironment, induce cancer cell apoptosis and autophagy, and suppress tumor development when administered alone or with other therapeutical strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	However, this is not the case for all cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "this", "is", "not", "the", "case", "for", "all", "cancers", "." ] } ...
PMC11471176	Note: X-axis units are as follows: 100 on the X-axis scale = 100 mM for carnosine, 10 nM of standard kit inhibitor, and 0.105 % of DMSO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470381	Convert the angles to degrees (.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Convert", "the", "angles", "to", "degrees", "(", "." ] } ]
PMC6650823	Fosmidomycin is a natural antibiotic whose antimalarial potential was unveiled at the turn of the 20th to the 21st century , paving the way towards the use of fosmidomycin in antimalarial combination therapies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	Dose reduction Index (DRI) is the dose which may be reduced in a combination to produce effect x as opposed to the dose of individual compound alone and is calculated as DRI 1= Dx1/ D1 and DRI 2 = Dx2/ D2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653533	On the other hand, the extracts also possessed analgesic activity by significant inhibition of acetic acid-induced writhing in mice, where, 200 and 400 mg/kg extract inhibited 42.23 and 57.76 % writhing, respectively (Mamidisetti et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496491	After reference genome transcriptome sequencing and subsequent bioinformatics analysis, the differentially expressed genes and related pathways were explored, and functional analysis of important genes and pathways was conducted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	Comparing OSE cells to PA-1, A2780, and OVCAR3 cells, MST-312 was not cytotoxic at concentrations up to 5 µM, but quercetin displayed a comparable cytotoxicity range as observed with PA-1 cancer cells (Supplementary Fig. 1E–L).	[ { "tags": [ "O", "B-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	Treatment of human colorectal carcinoma HCT116 cells and human Dukes’ type C colorectal adenocarcinoma SW620 cells with 5–20 μM HT for 24 h determined a raise in the apoptotic rates of both cell lines, ruled by a dose-dependent ROS accumulation detected after 4 h of incubation, which in turn was caused by HT direct inh...	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	He initially declined treatment.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "He", "initially", "declined", "treatment", "." ] } ]
PMC11766174	Thus, alternative approaches to quantitate the translationally active reservoir in bulk cells are needed to directly visualize CA at the single cell level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11267830	a RNA-seq analysis of the types and numbers of alternative splicing events that occur after indisulam treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "RNA-seq", "analysis", "of", "the", "ty...
PMC9219615	ERK 1/2 was one of three kinases hyperphosphorylated after treatment of cells with Tpz-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ERK", "1/2", "was", "one", "of", "three", "kinases", "hyperphosp...
PMC11772449	The Zero interaction potency (ZIP) model combines the advantages of the Bliss model and the Loewe model, and is more suitable for systematic evaluation of high-throughput drug combination screening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9599726	Ferrous iron was measured using the colorimetric QuantiChrom Iron Assay Kit (BioAssay Systems, CA, Cat# DIFE-250).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ferrous", "iron", ...
PMC11799620	This study confirms that Cd induces lipid peroxidation within erythrocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "confirms", "that", "Cd", "induces", "lipid", "peroxidation", "within", "erythro...
PMC6684588	Although ACE-083 treatment reduced creatine phosphokinase concentrations in mdx mice by 36% (Fig. 5b), this change did not reach statistical significance, perhaps due to the focal nature of ACE-083 treatment effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Right, box plot showing the minimum to maximum range of cPLA2 intensity (N = 3, n = 165 cells in 4 µm, n = 178 cells in 3 µm, n = 230 cells in 2 µm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	Integrating these approaches with ML models allows for the identification of predictive biomarkers and enables the development of highly personalized, effective therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6889484	Intriguingly, we were unable to select for A3G-D128K-resistant viral variants in multiple viral cultures for > 3.5 months, suggesting that A3G-D128K has a high genetic barrier to development of resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10391797	We observed that the AML cell line pretreated with VPA was connected with dose-dependent HDAC2 decrement and H4 expression (online supplemental figure S4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9681981	An increase in the etx gene expression was observed in the contact groups at 0, 2, and 5 h. However, the increase in the etx expression of the contact group at 5 h was not statistically significant compared to those at 2 h post-exposure (Table 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9532503	Post-diafiltration, the anti-CD20 antibody was further concentrated to 10 mg/mL. The final TFF pool was analyzed for step recovery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Post-diafiltration", ",", "t...
PMC9429973	P. Derigs, W. Bethge, U. Holtick, B. von Tresckow, F. Ayuk, O. Penack, V. Vucinic, M. von Bonin, C. Baldus, D. Mougiakakos, G. Wulf, U. Schnetzke, M. Stelljes, S. Thomas, R. Schroers, N. Kroeger, P. Dreger Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg; Department of Internal Medicine II,...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	After NPB treatment, apoptotic DNA laddering increased accompanied by increased CASPASE-3 and PARP cleavage, and γ-H2AX expression consistent with previous studies reporting that increased γ-H2AX levels may also indicate apoptosis (Supplementary Fig. 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11529598	E. Protein expression of E-cadherin, Vimentin was detected using western blot for assessment of epithelial-mesenchymal transition (EMT) We next explore the target genes through which miR-3154 regulate glioblastoma cells proliferation and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4695073	XPA has been reported to correlate with cisplatin cisplatin resistance in lung cancer cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "XPA", "has", "been", "reported", "to", "correlate", "with",...
PMC9786247	To avoid DNA contamination, RNA was purified with the RNase-free DNase set (Qiagen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "avoid", "DNA", "contamination", ",", "RNA", ...
PMC11204465	Since the discovery of sterigmatocystins in 1954 and aflatoxins in 1961, many scholars have conducted a series of studies on their structural identification, synthesis and biological activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5716223	During myogenic differentiation, muscle cells produce NGF and other neurotrophins as well as their receptors, tyrosine-kinase receptors (TrkA and TrkB) and p75-neurotrophin receptor (p75), able to act in autocrine manner on cell morphology, proliferation and differentiation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	This study identifies a critical role of Sema5A in the ENS as a regulator of neuronal activity and connectivity that might be compromised by ASD-associated mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	87.5% (14) of patients were male, and 12.5% (2) of patients were female.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "87.5", "%", "(", "14",...
PMC11621493	Plant PDAT is related to mammalian LCAT and crucially affects carbon flux into seed TAG stores (41).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plant", "PDAT", "is", "related", ...
PMC11790971	Each dot represents one cell in the test set.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "dot", "represents", "one", "cell", "in", "the", "test", "set", "." ] } ]
PMC7840816	TPC-1 and BCPAP cells were transfected with siRNA-SOX9 or siRNA-scramble, respectively.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TPC-1", "and", "BCPAP", "cells", "were", "transfected", "with", "siR...
PMC9964635	7f and the protein kinase B complex is stabilized by H-bonding and van der Waals interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7f", "and", "the", "protein", "kinase", "B", "co...
PMC9429973	Poor mobilizers were remobilized with G-CSF + Plerixafor and presented longer hospitalization (4 vs 2 days, P=0.001) and number of apheresis sessions (2 vs 1 days, P=0.001) when compared to group B. During mobilization, grade ≥3 complications were observed in 8.4% (n=3) in group A, being febrile neutropenia the most fr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7519871	Furthermore, in this investigation, it was established for the 1st time that WDL is cytotoxic against cervical cancer as determined in HeLa cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11753949	However, a major difference observed between the spine apparatus and the structures induced by synaptopodin overexpression in both neurons and COS-7 cells is the thickness of the actin bundles separating the ER cisterns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11216402	These predictions from gkm-SVM are validated by experiments showing strong RUNX2 and JUN (which binds AP-1) binding at Mes-like enhancers from ChIP-seq in LPS141 (Bevill et al. 2023) and strong KLF5, GATA4, and GATA6 binding at Epi-like enhancers from ChIP-seq generated in AGS (Fig. 1F; Supplemental Fig. S6; Chia et al...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: In Part B, 58 pts were enrolled and 57 pts received at least 1 dose of study treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "I...
PMC9847912	Each cell type was seeded into 48-well or 96-well assay plates, treated with varying concentrations of GSK232 (or water for solvent-only control wells), and cultured as described above for the spreading infection (CEMss) and single-cycle (293T/17 and MAGIC-5A) drug susceptibility assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774747	Lentiviral vectors have also been used and they offer the advantage of transducing both dividing and non-dividing cells, enhancing the flexibility and efficiency of CAR-VST manufacturing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: The state of bone homeostasis in children with ALL depends on anabolic and catabolic metabolic processes that provide energy substrate for bone formation, the level of iron stores in the body and hormonal regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11116779	Our future research will prioritize the comparison of the cytotoxicity of PS-NPs, varying their chemical composition and sizes in lung cells using a more advanced in vitro model in which epithelial lung cells are grown at the air-liquid interface (ALI) (58), thus better mimicking in vivo conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	LIM proteins act as DNA-binding transcription factors or facilitate protein-protein interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LIM", "proteins", "act", "as", "DNA-binding", "transcription", "factors", "or", "facilitate...
PMC11457557	Thus, the genetic discoveries in T2DM are challenged by the fact that the prevalence of DKD varies across ethnic populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "the"...
PMC11544122	The negative charge provided by the phosphates likely facilitates binding to SNX9, therefore we examined SNX9 binding to a phospho-mimetic CT peptide in which the phospho-cluster Ser residues were substituted with negatively charged Glu residues (CT-EE) (Supplementary Fig. S11b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525293	Since we did not find a wholly consistent matching between ΔNp63α downregulation and reduction of ACE2 protein levels with all shp63 RNAs, we generated stable transfected polyclonal populations with the shp63#3 and shp63#4 and the relative control with the shSCRB vector.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10958426	Heatmap of CNV level in reference normal cells and cancer cells, with rows and columns representing cells and genomic loci, respectively. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	At 1L, 94% of patients received R-CHOP with a median of 171.2 days (IQR: 61.0-247.5) between the end of their 1L and the start of their 2L treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11773391	Data are presented as the means ± standard errors from at least three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "means", "±", ...
PMC11612794	DNA was stained with DAPI.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "was", "stained", "with", "DAPI", "." ] } ]
PMC5916734	Panel C – Southern blotting of gDNA with biotin-labeled probes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Panel", "C", "–", "Southern", "blotting", "of", "gDNA", "with", "biotin-labeled", "probes", ...
PMC11747949	For CXCR1 analysis cells were analyzed with BD FACS Symphony A1 cell analyzer (Becton, Dickinson and Company, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "CXCR1...
PMC11473750	Scale bar: 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "20", "μm", "." ] } ]
PMC11655536	Data are expressed as mean ± standard error.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "as", "mean", "±", "standard", "error", "." ] } ]
PMC10671321	Cells extracts were performed by lysing the cells in Tris base 25 mM, NaCl 0.8 M, EDTA 10 mM, CHAPS 10 g/L, 2 mM Benzamidin and 40 µg/mL Leupeptin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	One 1L and 1 R/R patient achieved stable disease (no progression after 4 TAG cycles each), and 1 patient with R/R BPDCN progressed while on TAG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11357960	However, compared with the R group, the dots in the scatter plot of gene expression in the NR group appeared to be more scattered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11699042	Strikingly, we observed over 60 times more differentially expressed genes (DEG) defined as \|fold change (FC) \| > 1, Benjamini-Hochberg (BH) adjusted P < 0.01 (380 transcripts; 39 up-, 341 down-regulated) in the HeLa strains and 20 times more DEG (108 transcripts; 57 up-, 51 down-regulated) in the MCF-7 strains as compa...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765879	Ziziphus spina-christi (ZSC) is a plant species that grows in tropical regions and belongs to the genus Ziziphus, which is classified under the Rhamnaceae family .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	Source data are available online for this figure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "are", "available", "online", "for", "this", "figure", "." ] } ]
PMC10887351	Advances over the last two decades have proposed the targeting of β3-ARs for the treatment of several conditions, with some drugs undergoing phase II and III clinical trials and others already available for the treatments .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	This study did not generate new unique reagents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "did", "not", "generate", "new", "unique", "reagents", "." ] } ]
PMC10887351	The expression of the β3-AR mRNA levels was significantly increased in a rat model with an isoprenaline-induced cardiac hypertrophy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "the", ...
PMC11345828	Compound 59 (500 mg, 0.91, 1.0 equiv) and ethyl 5-(benzyloxy)-4-ethoxy-7-iodo-1H-indole-2-carboxylate (720 mg, 1.54 mmol, 1.7 equiv) were coupled following General Procedure A (580 mg, 72% yield), LCMS Method 2: RT = 1.676 min, MS (ES) 888.10 (M + H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516447	Next, taking advantage of the two GRP78 small molecule inhibitors HA15 and YUM70 which specifically bind GRP78 and inhibit its ATPase activity, we tested the effect of these clinically relevant agents on KRAS expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	h and i Correlation of PTPRZ1 expression and GSC module score in malignant cells in IPTOs and frequency of GSC upon TCR-T cell treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11407042	10× Lysis Solution (provided by kit) should be added 45 min before adding CytoTox 96 Reagent (provided by The Kit).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8540692	The HPLC separation was carried out on a Phenomenex-C18 column (250 mm × 4.6 mm; 5 µm), the temperature of the column set at 303 K, using a mobile phase consisted of 1% acetic acid and acetonitrile (45:55, v/v), with the flow rate 1.0 mL/min (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8348645	This HPLC result suggested the presence of compounds responsible for anti-carcinogenic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "HPLC", "result", "suggested", "the", "presence", "of", "compounds", "res...
PMC10788478	The gene expression levels were determined using the 2 method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gene", "expression", "levels", "were", "determined", "using", "the", "2", "method", ...
PMC11694066	The culture medium was changed every other day with recovery of suspended cells by centrifugation at 1,200 rpm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "culture", "medium", "was", "cha...
PMC11698348	In catagen skin, weak Elf5 expression was restricted to the basal layer of epidermis and in the regressing epithelial strand of the HFs (D18, Fig 1e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	Our study adds to the growing list of GPCRs for which agonist-stimulated internalization is independent of β-arrestins (Moo et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7823217	In laser-assisted bioprinting (otherwise called biological laser printing, LAB), to generate vaporizing sacrificial layer, laser energy is used in the system to push a cargo to a receiving substrate (in nozzle-free bioprinting) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	Initial 28.5% complete or partial response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initial", "28.5", "%", "complete", "or", "partial", "response", "." ] } ]
PMC11609529	Immunohistochemistry (IHC) staining was conducted by the Molecular Pathology Core at the University of Florida following established protocols as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoh...
PMC9429973	Further study with a prospective randomised control trial is required.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "study", "with", "a", "prospective", "randomised", "control", "trial", "is", "required...
PMC11519077	The quantification of mRNA was performed as a value relative to an internal reference for GAPDH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quantification", "of", "mRNA", "was", "performe...
PMC9429973	K. Shimada, K. Ohmachi, R. Machida, S. Ota, H. Itamura, H. Tsujimura, N. Takayama, T. Shimada, M. Kurosawa, T. Tabayashi, T. Shimoyama, K. Ohshima, D. Maruyama, T. Kinoshita, K. Ando, T. Hotta, K. Tsukasaki, H. Nagai Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya; Departmen...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8609870	b Listed the interactions between hsa-miR-210-5p and 3 genesFig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Listed", "the", "interactions", "between", "hsa-miR-210", "-", "5p", "and", "3",...
PMC6442998	Immunofluorescence.	[ { "tags": [ "O", "O" ], "tokens": [ "Immunofluorescence", "." ] } ]
PMC11474209	Liver toxicity32Human melanoma cancerCell (MDA-MB−435)0–50 nMMMP−2, MMP−9, NF-κBPI3-K/AKTCell invasion promotes tumor growth, cancer progression, and the onset of apoptosis in melanoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9559528	With any skin manifestation, a detailed history may clue a clinician into a disease course that may be atypical.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "any", "skin", ...
PMC11615101	P ≤0.05, P ≤0.01, * P ≤0.001, **** P ≤0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "≤0.05", ",",...
PMC10878518	Representative histograms in each sample were shown (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "histograms", "in", "each", "sample", "were", "shown", "(", "A", ")", "."...
PMC11474209	Most of the percentage of MCLR is excreted out by the biliary route, approximately 15 % of ingested MC-LR is excreted in the faces, and the remaining percentage of MC-LR accumulates in the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587298	Co-incubation of cells with MGO and elderberry extracts resulted in a lower MGO cytotoxicity for HepG2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Co-incubation", "of", "cells", "with", "...
PMC9910796	As shown above, the absence of pEP84R during ASFV infection leads to the formation of defective icosahedral particles lacking a proper core shell as well as the internal DNA-containing nucleoid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11726183	One of the leading causes of mortality worldwide is cancer, which is seen as a significant barrier to increasing life expectancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", ...
PMC10723784	Although the present study investigated several pathways involved in apoptosis in mediating the cytotoxicity induced by cannabinoids, however, it is worth indicating that one of the limitations of this work is that CBD and CBG have been screened against a limited number of human ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	MCL tumor mutations were identified with a MCL NGS panel and excluded from CH analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MCL", "tumor", "mutations", "were", "identified", "with", "...
PMC7081114	Furthermore, KIF21B may prove useful as an ideal target for gene therapy for HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "KIF21B", "may", "prove", "useful", "as"...
PMC8922418	HIV-1 invades target cells by binding its envelope surface protein gp120 to the CD4 main receptor on the membrane of the target cell, and then interacts with the chemokine co-receptor CCR5 or CXCR4 (Alkhatib et al., 1996; Bleul et al., 1996).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	Specifically, we categorized CDR3β residues into V, J, and CDR3βmer (central) regions: The V and J regions comprise the highly conserved n- and c-terminal motifs respectively; while the central CDR3βmer region, which primarily contacts the antigen, is the most diverse in length and amino acid usage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Agranulocytosis lasted from 6 to 97 days (median 12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Agranulocytosis", "lasted", "from", "6", "to", "97", "days", "(", "median", "12", ...
PMC11607764	Distribution of the protein expression levels of PTBP1 in different cancer types was also conducted in clinical proteomic tumor analysis consortium (CPTAC) dataset by using UALCAN (https://ualcan.path.uab.edu/analysis-prot.html).UALCAN provides protein expression analysis for breast cancer, ovarian cancer, colon cancer...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742864

The ω-3 LCPUFAs, primarily consisting of eicosapentaenoic acid and docosahexaenoic acid, were found to modify inflammatory tumor microenvironment, induce cancer cell apoptosis and autophagy, and suppress tumor development when administered alone or with other therapeutical strategies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10203589

However, this is not the case for all cancers.

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PMC11471176

Note: X-axis units are as follows: 100 on the X-axis scale = 100 mM for carnosine, 10 nM of standard kit inhibitor, and 0.105 % of DMSO.

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PMC11470381

Convert the angles to degrees (.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Convert", "the", "angles", "to", "degrees", "(", "." ] } ]

PMC6650823

Fosmidomycin is a natural antibiotic whose antimalarial potential was unveiled at the turn of the 20th to the 21st century , paving the way towards the use of fosmidomycin in antimalarial combination therapies .

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PMC9596868

Dose reduction Index (DRI) is the dose which may be reduced in a combination to produce effect x as opposed to the dose of individual compound alone and is calculated as DRI 1= Dx1/ D1 and DRI 2 = Dx2/ D2.

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PMC11653533

On the other hand, the extracts also possessed analgesic activity by significant inhibition of acetic acid-induced writhing in mice, where, 200 and 400 mg/kg extract inhibited 42.23 and 57.76 % writhing, respectively (Mamidisetti et al., 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11496491

After reference genome transcriptome sequencing and subsequent bioinformatics analysis, the differentially expressed genes and related pathways were explored, and functional analysis of important genes and pathways was conducted.

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PMC9596868

Comparing OSE cells to PA-1, A2780, and OVCAR3 cells, MST-312 was not cytotoxic at concentrations up to 5 µM, but quercetin displayed a comparable cytotoxicity range as observed with PA-1 cancer cells (Supplementary Fig. 1E–L).

[ { "tags": [ "O", "B-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10968586

Treatment of human colorectal carcinoma HCT116 cells and human Dukes’ type C colorectal adenocarcinoma SW620 cells with 5–20 μM HT for 24 h determined a raise in the apoptotic rates of both cell lines, ruled by a dose-dependent ROS accumulation detected after 4 h of incubation, which in turn was caused by HT direct inh...

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PMC9429973

He initially declined treatment.

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "He", "initially", "declined", "treatment", "." ] } ]

PMC11766174

Thus, alternative approaches to quantitate the translationally active reservoir in bulk cells are needed to directly visualize CA at the single cell level.

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PMC11267830

a RNA-seq analysis of the types and numbers of alternative splicing events that occur after indisulam treatment.

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PMC9219615

ERK 1/2 was one of three kinases hyperphosphorylated after treatment of cells with Tpz-1.

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PMC11772449

The Zero interaction potency (ZIP) model combines the advantages of the Bliss model and the Loewe model, and is more suitable for systematic evaluation of high-throughput drug combination screening.

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PMC9599726

Ferrous iron was measured using the colorimetric QuantiChrom Iron Assay Kit (BioAssay Systems, CA, Cat# DIFE-250).

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PMC11799620

This study confirms that Cd induces lipid peroxidation within erythrocytes.

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PMC6684588

Although ACE-083 treatment reduced creatine phosphokinase concentrations in mdx mice by 36% (Fig. 5b), this change did not reach statistical significance, perhaps due to the focal nature of ACE-083 treatment effects.

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PMC11224020

Right, box plot showing the minimum to maximum range of cPLA2 intensity (N = 3, n = 165 cells in 4 µm, n = 178 cells in 3 µm, n = 230 cells in 2 µm).

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PMC11767725

Integrating these approaches with ML models allows for the identification of predictive biomarkers and enables the development of highly personalized, effective therapeutic strategies.

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PMC6889484

Intriguingly, we were unable to select for A3G-D128K-resistant viral variants in multiple viral cultures for > 3.5 months, suggesting that A3G-D128K has a high genetic barrier to development of resistance.

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PMC10391797

We observed that the AML cell line pretreated with VPA was connected with dose-dependent HDAC2 decrement and H4 expression (online supplemental figure S4B).

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PMC9681981

An increase in the etx gene expression was observed in the contact groups at 0, 2, and 5 h. However, the increase in the etx expression of the contact group at 5 h was not statistically significant compared to those at 2 h post-exposure (Table 5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9532503

Post-diafiltration, the anti-CD20 antibody was further concentrated to 10 mg/mL. The final TFF pool was analyzed for step recovery.

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PMC9429973

P. Derigs, W. Bethge, U. Holtick, B. von Tresckow, F. Ayuk, O. Penack, V. Vucinic, M. von Bonin, C. Baldus, D. Mougiakakos, G. Wulf, U. Schnetzke, M. Stelljes, S. Thomas, R. Schroers, N. Kroeger, P. Dreger Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg; Department of Internal Medicine II,...

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PMC9250505

After NPB treatment, apoptotic DNA laddering increased accompanied by increased CASPASE-3 and PARP cleavage, and γ-H2AX expression consistent with previous studies reporting that increased γ-H2AX levels may also indicate apoptosis (Supplementary Fig. 5E).

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PMC11529598

E. Protein expression of E-cadherin, Vimentin was detected using western blot for assessment of epithelial-mesenchymal transition (EMT) We next explore the target genes through which miR-3154 regulate glioblastoma cells proliferation and metastasis.

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PMC4695073

XPA has been reported to correlate with cisplatin cisplatin resistance in lung cancer cell lines .

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PMC9786247

To avoid DNA contamination, RNA was purified with the RNase-free DNase set (Qiagen).

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PMC11204465

Since the discovery of sterigmatocystins in 1954 and aflatoxins in 1961, many scholars have conducted a series of studies on their structural identification, synthesis and biological activities.

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PMC5716223

During myogenic differentiation, muscle cells produce NGF and other neurotrophins as well as their receptors, tyrosine-kinase receptors (TrkA and TrkB) and p75-neurotrophin receptor (p75), able to act in autocrine manner on cell morphology, proliferation and differentiation .

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PMC11033180

This study identifies a critical role of Sema5A in the ENS as a regulator of neuronal activity and connectivity that might be compromised by ASD-associated mutations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

87.5% (14) of patients were male, and 12.5% (2) of patients were female.

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PMC11621493

Plant PDAT is related to mammalian LCAT and crucially affects carbon flux into seed TAG stores (41).

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PMC11790971

Each dot represents one cell in the test set.

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PMC7840816

TPC-1 and BCPAP cells were transfected with siRNA-SOX9 or siRNA-scramble, respectively.

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PMC9964635

7f and the protein kinase B complex is stabilized by H-bonding and van der Waals interactions.

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PMC9429973

Poor mobilizers were remobilized with G-CSF + Plerixafor and presented longer hospitalization (4 vs 2 days, P=0.001) and number of apheresis sessions (2 vs 1 days, P=0.001) when compared to group B. During mobilization, grade ≥3 complications were observed in 8.4% (n=3) in group A, being febrile neutropenia the most fr...

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PMC7519871

Furthermore, in this investigation, it was established for the 1st time that WDL is cytotoxic against cervical cancer as determined in HeLa cell line.

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PMC11753949

However, a major difference observed between the spine apparatus and the structures induced by synaptopodin overexpression in both neurons and COS-7 cells is the thickness of the actin bundles separating the ER cisterns.

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PMC11216402

These predictions from gkm-SVM are validated by experiments showing strong RUNX2 and JUN (which binds AP-1) binding at Mes-like enhancers from ChIP-seq in LPS141 (Bevill et al. 2023) and strong KLF5, GATA4, and GATA6 binding at Epi-like enhancers from ChIP-seq generated in AGS (Fig. 1F; Supplemental Fig. S6; Chia et al...

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PMC9429973

Results: In Part B, 58 pts were enrolled and 57 pts received at least 1 dose of study treatment.

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PMC9847912

Each cell type was seeded into 48-well or 96-well assay plates, treated with varying concentrations of GSK232 (or water for solvent-only control wells), and cultured as described above for the spreading infection (CEMss) and single-cycle (293T/17 and MAGIC-5A) drug susceptibility assays.

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PMC11774747

Lentiviral vectors have also been used and they offer the advantage of transducing both dividing and non-dividing cells, enhancing the flexibility and efficiency of CAR-VST manufacturing.

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PMC9429973

Summary/Conclusion: The state of bone homeostasis in children with ALL depends on anabolic and catabolic metabolic processes that provide energy substrate for bone formation, the level of iron stores in the body and hormonal regulation.

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PMC11116779

Our future research will prioritize the comparison of the cytotoxicity of PS-NPs, varying their chemical composition and sizes in lung cells using a more advanced in vitro model in which epithelial lung cells are grown at the air-liquid interface (ALI) (58), thus better mimicking in vivo conditions.

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PMC11794568

LIM proteins act as DNA-binding transcription factors or facilitate protein-protein interactions.

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PMC11457557

Thus, the genetic discoveries in T2DM are challenged by the fact that the prevalence of DKD varies across ethnic populations.

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PMC11544122

The negative charge provided by the phosphates likely facilitates binding to SNX9, therefore we examined SNX9 binding to a phospho-mimetic CT peptide in which the phospho-cluster Ser residues were substituted with negatively charged Glu residues (CT-EE) (Supplementary Fig. S11b).

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PMC11525293

Since we did not find a wholly consistent matching between ΔNp63α downregulation and reduction of ACE2 protein levels with all shp63 RNAs, we generated stable transfected polyclonal populations with the shp63#3 and shp63#4 and the relative control with the shSCRB vector.

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PMC10958426

Heatmap of CNV level in reference normal cells and cancer cells, with rows and columns representing cells and genomic loci, respectively. (

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PMC9429973

At 1L, 94% of patients received R-CHOP with a median of 171.2 days (IQR: 61.0-247.5) between the end of their 1L and the start of their 2L treatments.

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PMC11773391

Data are presented as the means ± standard errors from at least three independent experiments.

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PMC11612794

DNA was stained with DAPI.

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PMC5916734

Panel C – Southern blotting of gDNA with biotin-labeled probes.

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PMC11747949

For CXCR1 analysis cells were analyzed with BD FACS Symphony A1 cell analyzer (Becton, Dickinson and Company, USA).

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PMC11473750

Scale bar: 20 μm.

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PMC11655536

Data are expressed as mean ± standard error.

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PMC10671321

Cells extracts were performed by lysing the cells in Tris base 25 mM, NaCl 0.8 M, EDTA 10 mM, CHAPS 10 g/L, 2 mM Benzamidin and 40 µg/mL Leupeptin.

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PMC9429973

One 1L and 1 R/R patient achieved stable disease (no progression after 4 TAG cycles each), and 1 patient with R/R BPDCN progressed while on TAG.

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PMC11357960

However, compared with the R group, the dots in the scatter plot of gene expression in the NR group appeared to be more scattered.

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PMC11699042

Strikingly, we observed over 60 times more differentially expressed genes (DEG) defined as |fold change (FC) | > 1, Benjamini-Hochberg (BH) adjusted P < 0.01 (380 transcripts; 39 up-, 341 down-regulated) in the HeLa strains and 20 times more DEG (108 transcripts; 57 up-, 51 down-regulated) in the MCF-7 strains as compa...

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PMC11765879

Ziziphus spina-christi (ZSC) is a plant species that grows in tropical regions and belongs to the genus Ziziphus, which is classified under the Rhamnaceae family .

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PMC11377827

Source data are available online for this figure.

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PMC10887351

Advances over the last two decades have proposed the targeting of β3-ARs for the treatment of several conditions, with some drugs undergoing phase II and III clinical trials and others already available for the treatments .

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PMC9065483

This study did not generate new unique reagents.

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PMC10887351

The expression of the β3-AR mRNA levels was significantly increased in a rat model with an isoprenaline-induced cardiac hypertrophy .

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PMC11345828

Compound 59 (500 mg, 0.91, 1.0 equiv) and ethyl 5-(benzyloxy)-4-ethoxy-7-iodo-1H-indole-2-carboxylate (720 mg, 1.54 mmol, 1.7 equiv) were coupled following General Procedure A (580 mg, 72% yield), LCMS Method 2: RT = 1.676 min, MS (ES) 888.10 (M + H).

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PMC9516447

Next, taking advantage of the two GRP78 small molecule inhibitors HA15 and YUM70 which specifically bind GRP78 and inhibit its ATPase activity, we tested the effect of these clinically relevant agents on KRAS expression.

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PMC11787355

h and i Correlation of PTPRZ1 expression and GSC module score in malignant cells in IPTOs and frequency of GSC upon TCR-T cell treatment.

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PMC11407042

10× Lysis Solution (provided by kit) should be added 45 min before adding CytoTox 96 Reagent (provided by The Kit).

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PMC8540692

The HPLC separation was carried out on a Phenomenex-C18 column (250 mm × 4.6 mm; 5 µm), the temperature of the column set at 303 K, using a mobile phase consisted of 1% acetic acid and acetonitrile (45:55, v/v), with the flow rate 1.0 mL/min (1).

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PMC8348645

This HPLC result suggested the presence of compounds responsible for anti-carcinogenic activity.

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PMC10788478

The gene expression levels were determined using the 2 method.

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PMC11694066

The culture medium was changed every other day with recovery of suspended cells by centrifugation at 1,200 rpm.

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PMC11698348

In catagen skin, weak Elf5 expression was restricted to the basal layer of epidermis and in the regressing epithelial strand of the HFs (D18, Fig 1e).

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PMC11585254

Our study adds to the growing list of GPCRs for which agonist-stimulated internalization is independent of β-arrestins (Moo et al., 2021).

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PMC7823217

In laser-assisted bioprinting (otherwise called biological laser printing, LAB), to generate vaporizing sacrificial layer, laser energy is used in the system to push a cargo to a receiving substrate (in nozzle-free bioprinting) .

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PMC10976516

Initial 28.5% complete or partial response.

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PMC11609529

Immunohistochemistry (IHC) staining was conducted by the Molecular Pathology Core at the University of Florida following established protocols as previously described.

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PMC9429973

Further study with a prospective randomised control trial is required.

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PMC11519077

The quantification of mRNA was performed as a value relative to an internal reference for GAPDH.

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PMC9429973

K. Shimada, K. Ohmachi, R. Machida, S. Ota, H. Itamura, H. Tsujimura, N. Takayama, T. Shimada, M. Kurosawa, T. Tabayashi, T. Shimoyama, K. Ohshima, D. Maruyama, T. Kinoshita, K. Ando, T. Hotta, K. Tsukasaki, H. Nagai Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya; Departmen...

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PMC8609870

b Listed the interactions between hsa-miR-210-5p and 3 genesFig.

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PMC6442998

Immunofluorescence.

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PMC11474209

Liver toxicity32Human melanoma cancerCell (MDA-MB−435)0–50 nMMMP−2, MMP−9, NF-κBPI3-K/AKTCell invasion promotes tumor growth, cancer progression, and the onset of apoptosis in melanoma cells.

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PMC9559528

With any skin manifestation, a detailed history may clue a clinician into a disease course that may be atypical.

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PMC11615101

P ≤0.05, ** P ≤0.01, *** P ≤0.001, **** P ≤0.0001).

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PMC10878518

Representative histograms in each sample were shown (A).

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PMC11474209

Most of the percentage of MCLR is excreted out by the biliary route, approximately 15 % of ingested MC-LR is excreted in the faces, and the remaining percentage of MC-LR accumulates in the cells.

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PMC9587298

Co-incubation of cells with MGO and elderberry extracts resulted in a lower MGO cytotoxicity for HepG2 cells.

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PMC9910796

As shown above, the absence of pEP84R during ASFV infection leads to the formation of defective icosahedral particles lacking a proper core shell as well as the internal DNA-containing nucleoid.

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PMC11726183

One of the leading causes of mortality worldwide is cancer, which is seen as a significant barrier to increasing life expectancy.

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PMC10723784

Although the present study investigated several pathways involved in apoptosis in mediating the cytotoxicity induced by cannabinoids, however, it is worth indicating that one of the limitations of this work is that CBD and CBG have been screened against a limited number of human ovarian cancer cells.

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PMC9429973

MCL tumor mutations were identified with a MCL NGS panel and excluded from CH analyses.

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PMC7081114

Furthermore, KIF21B may prove useful as an ideal target for gene therapy for HCC.

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PMC8922418

HIV-1 invades target cells by binding its envelope surface protein gp120 to the CD4 main receptor on the membrane of the target cell, and then interacts with the chemokine co-receptor CCR5 or CXCR4 (Alkhatib et al., 1996; Bleul et al., 1996).

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PMC11802929

Specifically, we categorized CDR3β residues into V, J, and CDR3βmer (central) regions: The V and J regions comprise the highly conserved n- and c-terminal motifs respectively; while the central CDR3βmer region, which primarily contacts the antigen, is the most diverse in length and amino acid usage.

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PMC9429973

Agranulocytosis lasted from 6 to 97 days (median 12).

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PMC11607764

Distribution of the protein expression levels of PTBP1 in different cancer types was also conducted in clinical proteomic tumor analysis consortium (CPTAC) dataset by using UALCAN (https://ualcan.path.uab.edu/analysis-prot.html).UALCAN provides protein expression analysis for breast cancer, ovarian cancer, colon cancer...

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