OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	Methods: We retrospectively reviewed data of patients aged over 65 years diagnosed with MM and treated at the hematology department of Hedi Chaker Hospital Sfax between January 2012 and December 2019.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6934009	Cell study.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Cell", "study", "." ] } ]
PMC11672617	The assay is a valuable tool for screening compounds and elucidating the kinetics of dose-dependent processes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "assay", "is", "a", "valuable", "tool", "f...
PMC11638255	g Concentration of copper in conditioned media before and after 30 min incubation with naive neutrophils isolated from healthy donors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Concentration", "of", ...
PMC11777207	All patients provided written and informed consent, and the study was approved by the institutional review board at the University of Colorado-Anschutz under COMIRB # 17-2159 and 06-0566.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	This modulation is achieved by inhibiting the phosphorylation of JNK and p65, resulting in decreased expression of iNOS and IL-1β, thereby suppressing the production of inflammatory factors such as IL-6 and IL-1β (Wang et al., 2021a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Genomic copy number gain (red) or loss (blue) of chromosomes 1, 8, 9, 13 and 18 of progeny HEK293 cell lines compared to parental HEK293 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC7709199	Per roller bottle (300 ml expression volume), 50 ml transfection mixture containing 500 µg DNA at a 1:1 DNA:PEI ratio in Dulbecco’s Modified Eagle’s Medium (DMEM) was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772449	There are many ways to analyze and judge the interaction forms of the two drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "are", "many", "ways", "to", "analyze", "and", ...
PMC11638288	In summary, NKp46 facilitates the progression of type 1 diabetes by inducing NK cell degranulation through its interaction with the ligand, leading to the destruction of pancreatic β-cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The lack of response to corticosteroids shall induce introduction of novel therapies sooner in the treatment course of suspected ES cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lack", "of...
PMC9429973	First line treatment of tMZL was with anthracycline containing chemoimmunotherapy in 84% of cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", "line", "treatment", "of", "tMZL", "was", "with", ...
PMC8382973	Despite repeated tissue sampling and 2P23 gel treatment, the inflammatory cytokines and microbiota of the rectum and vagina remained stable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "repeated", ...
PMC5874706	The concentration of staurosporin used in the experiment was 0.5 µM. After 24 h and 48 h, respectively, 10 μL of the MTT solution (5 mg/mL in PBS) were added to each well and the plate was incubated for 2 h at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	Thus, they may be responsible for forming the pre-metastatic niche.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "they", "may", "be", "responsible", "for", "forming", "the", "pre-metasta...
PMC11634027	I′,J′) Rose plots showing quantification of Dachs polarity, with distal at bottom, in Flp-out clones from the genotypes shown in I (n=161 cells from nine discs) and J (n=137 cells from ten discs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	Scale bar = 1 µm, N = 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "1", "µm", ",", "N", "=", "3", "." ] } ]
PMC11412721	We previously used this model to show that p53-AS isoforms had no role in the anemia affecting Trp53 mice (Simeonova et al., 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10674574	However, the data presented (Table 5) show that Caco-2 monolayers with a TERR of at least 300 ohms are commonly used for permeability studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: The analysis included 62 patients with acute myeloid leukemia (AML, n=30) and acute lymphoblastic leukemia (ALL, n=32) who underwent haplo-HSCT at the National Medical Research Center for Hematology in the period from May 2018 to February 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9776316	Moreover, in our previous study, we found that the DGKA signals through JNK-cJUN drive the transcription of WEE1, a kinase involved in DNA damage checking point response 26.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	Permeabilization assay was performed for both µsPEF and nsPEF using 1.2 kV/cm and 2.5–10 kV/cm pulse amplitudes, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Permeabilization", "assay", "was", ...
PMC11792740	Future research should focus on integrating multiple therapeutic strategies to address the multifactorial nature of T-cell exhaustion, thereby enhancing the overall effectiveness of cancer immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11457557	However, despite these measures, many people with DKD still progress to end-stage renal disease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "despite", "these", "measures", ",", ...
PMC9429973	Dresden, Germany; University of Rome “Cattolica S. Cuore”, Rome, Italy; Hospital Universitario y Politécnico La Fe; Instituto de Salud Carlos III (CIBERONC), Valencia, Spain; Novartis, Oncology Region Europe, Basel, Switzerland; University Hospital of Ulm; Ulm University Hospital, Ulm; Hannover Medical School, Hannover...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9672323	al indicated that aspirin and metformin induce apoptosis in 4T1 cells through an increment in TGF-β secretion by these cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "al", "indicated", "...
PMC11267830	e Body weight changes in the two preclinical leukemia mouse models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "e", "Body", "weight", "changes", "in", "the", "two", "preclinical", "leukemia", "mous...
PMC11247842	We assigned the genotype to CNV following and treated 3 copies as 2 copies (wild type) as no cases with 3 copies were reported in and it could be an estimation error due to lower coverage in our dataset compared to the previous study .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11454015	Estrogen receptor (ER) expression and E-cadherin (CDH1) loss are the two major molecular hallmarks of invasive lobular carcinoma (ILC) of the breast; however, it is unclear how ER signaling and E-cadherin loss crosstalk during ILC tumor formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11281366	The following Abs were used in flow cytometry assays: BV421 anti-human CCR5 (Biolegend, #359118), PE/Cyanine7 anti-human CD4 (Biolegend, #317414) and PE anti-human CD59 (Miltenyi, #130-120-048), as well as its isotype control (Miltenyi, #130-113-438).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9786247	Identification of particular genetic determinants encoding for host adaptation and virulence was beyond the scope of this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Identification", "of", "particular", "geneti...
PMC2196094	A nearly full-length cDNA clone for RMCP-9 was isolated (Figs. 2 B and 5 B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "nearly", "full-length", "cDNA", "clone", ...
PMC9621239	Therefore, the protein levels of CDT1 and ATM in HCC cells were assessed using Western blot assays, wherein the HCC cells stably expressing HBx-TM had higher CDT1 and ATM protein levels compared with the HCC cells stably expressing HBx-WT (Figures S9E and S9F), suggesting that the presence of DNA DSB in the HCC cell li...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11026382	For comparison, we also mapped the model-predicted catalytic power averaged across all mutations at a position to the structure (Fig. 7e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11599565	Results are representative of n = 3 experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "representative", "of", "n", "=", "3", "experiments", "." ] } ]
PMC9429973	Reductions in Ikaros/Aiolos protein levels in tumor cells were observed at all dose levels in both cohorts with a >90% reduction at the 0.45-mg dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257988	Additionally, the research group conducted experiments with BI-2865 to inhibit NRAS and HRAS mutant cells, revealing that the inhibitor’s ability to inhibit nucleotide exchange in HRAS or NRAS is several orders of magnitude lower than that in KRAS, and this difference is attributed to direct and/or indirect constraints...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11064533	After the 24 h, OD600 was measured for each well with the Tecan microplate reader (Tecan, Austria).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the", "2...
PMC9429973	Methods: ACTIVATE was a phase 3, global, double-blind, placebo (PBO)-controlled study of mitapivat in adults with PK deficiency who were not regularly transfused (≤4 transfusion episodes in prior year [yr]; none in prior 3 months).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	To explore immunophenotic and molecular genetic markers we use three state “illness-death” model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "explore", "immunophenotic", "and", "molecular", "genetic", ...
PMC2944824	We suggest that the developmental changes in Hr expression explains, in part, why cell death occurs more commonly through apoptosis in the immature rat brain whereas cell death through necrosis is more commonly observed in the adult , .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9739791	The induced DNA damage and oxidative stress activate apoptosis, which leads to cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "induced", "DNA", "damage", "and", "oxidative", "stre...
PMC10652261	As depicted in Figure 7, the percentages of caspase 3(+) K562 cells treated with compounds 2e, 2f, 2h, and bortezomib were found as 58.6, 30.1, 57.2, and 19.7%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	A. Schematic outlining screen for bacterial effectors that rescue arbovirus restriction in LD652 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A.", "Schematic", "outlining", "screen", "for", "bacterial", "effector...
PMC11469524	After applying parameter stability analysis using profile likelihood, we noted that of the 15 shared links only 2 (AKT->BAD, MEK->ERK) are not significantly different (i.e., 95% confidence intervals do not overlap; S2 Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9046263	p < 0.05.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "." ] } ]
PMC11628904	Quantification of burn depth over time with the indicated treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "burn", "depth", "over", "time", "with", "the", "indicated", "treatment",...
PMC11489351	Notch1 reporter fluorescence is shown in intensiometric display, and nuclei were stained with Hoechst dye (DAPI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notch1", "reporter", "fluorescence", ...
PMC11277157	Only evidence of physical interactions was included .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "evidence", "of", "physical", "interactions", "was", "included", "." ] } ]
PMC11087301	Moreover, leptin signaling has been found to elevate cell viability, migratory and invading abilities, and CSC- and EMT-correlated gene expression in breast cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9545714	Likewise, TNF‐α is not upregulated at 6 h, but TNFIP3 (TNF α‐induced protein 3) is upregulated indicating the TNF gene was upregulated earlier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Each sample was mixed for quality control (QC) with the same pretreatment as the study samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "sample", "was", "mixed", "for"...
PMC11635087	Although the maintenance of photosynthetic activity in isolated chloroplasts in vitro has been reported, our study is the first to measure the photosynthetic activity of chloroplasts in mammalian cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	Single-cell data were sourced from the Tumor Immune Single-cell Hub (TISCH).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-cell", "data", "were", "sourced", "from", "the", "Tumor", "Immune", ...
PMC9429973	Impact on PB and EB was higher in MF and PV as compared to ET: PB = 28.6 and 21.4 vs 14.3; EB = 31.8 and 27.3 vs 22.7, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	One exception to this trend was human RNF214, which was dramatically reduced in level when co-expressed with GFP-IpaH4 (S4B Fig).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", ...
PMC9429973	The type of functional impact of each mutation depends on the protein region where the replacement occurs Image: Summary/Conclusion: Clinical studies and structural bioinformatics should work together towards precision medicine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6892818	Therefore, although mCD40L induces extensive apoptosis in malignant (RCC) cells, normal cells remain totally refractory to mCD40L.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", ...
PMC7504302	Taken together, further studies may provide the basis for assessing TGF-β pathway-specific inhibitors for targeted therapy in MPM, at least in those with high EMT scores.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Efficacy and toxicity in our cohort are comparable with ZUMA-1 study results and other large real world cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Efficacy", "and", "toxicity", "in", "o...
PMC11756514	An example is the recognition of unusual patterns of surface carbohydrates on microorganisms by carbohydrate-binding proteins of the host.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "example", "is", "the", ...
PMC11761919	4Detection of humoral and cellular immune responses to oral immunization with microsphere containing Fiber2-expressing E. faecalis plus PINs or inulin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4Detection", "of", "humoral"...
PMC10748106	Among natural products, iridoids have shown different biological activities, including cytotoxic and antitumor effects, in different cancer cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "nat...
PMC11754291	While lower intensities preserved metabolic activity and α-MSH production at baseline levels, intermediate intensity (10 mW/cm, 15 J/cm) optimally stimulated α-MSH production with minimal cytotoxic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10734950	In conclusion, DNA fragmentation was evident upon the treatment of F8 on the CCRF-CEM cell line after 72 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ...
PMC10890055	We also prepared extracts of Zn-based biomaterials and tested the cytotoxicity of these extracts on the two cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "prepared", "extract...
PMC5810978	We did not verify our results by other methods (e.g. nonstructural protein expression, dsRNA detection, (-) strand RNA detection, etc).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655498	In summary, these cellular factors can directly bind to Zp and Rp or recruit other factors for binding, thereby modulating their transcription activity and initiating subsequent processes in EBV reactivation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11420784	The prototypic FYVE protein is EEA1, which is the early endosomal autoantigen that mediates early endosome fusion .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prototypic", "FYVE", "protein", ...
PMC10656496	Another way to conceptualize these cell lines is that 143B is a “cream skimmer” that is more fit in times of optimal environmental conditions while SAOS2 is a “crumb picker” able to adapt to suboptimal conditions, including chemotherapeutic selection, and thus increases fitness relative to 143B at suboptimal times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11535726	Scale bars: 100 μm (c, d); 20 μm (e–l).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "100", "μm", ...
PMC10587429	The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "raw", "data", "...
PMC5941560	Yearly publication counts for PubMed queries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yearly", "publication", "counts", "for", "PubMed", "queries", "." ] } ]
PMC11394386	Recently, the role of long non-coding RNAs (LncRNAs) as essential effectors of signaling pathways in cancer development has been extensively explored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10291556	The uptake of the platinum complexes by HeLa cells was determined as the platinum amount per 10 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "uptake", "of", "the", ...
PMC8956657	Numbers next to nodes indicate bootstrap proportion support, and the scale indicates the number of nucleotide substitutions per site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numbers", "next", "to", ...
PMC11597167	CT values were exported from the BioRad CFX Connect real-time qPCR system and normalized against a reference gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CT", "values", "were", "exported", "fr...
PMC11683130	In general, neutrophils play an important role in the initiation and maintenance of psoriasis through ROS production, degranulation and NET formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC8592717	Basil (Ocimum basilicum), lemon thyme (Thymus citriodorus), and mint (Mentha sp.), belonging to the mint family, which are used as culinary herbs in many countries, contain many antioxidant and anti-inflammatory phenolic compounds such as PCA and PAL among others [23-26].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365983	We demonstrate that altering the level of Foxc1 protein, via shRNA mediated inhibition, CRISPR/Cas9 mutagenesis and overexpression, modifies cilia length in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8759873	Research has found that the VHL gene-hypoxia-inducible factor-hypoxia response gene pathway (VHL-HIF-HRG pathway) plays an important role in kidney cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "...
PMC9429973	Total ESAS-R score decreased by 10 points at 18 mos of therapy as compared to baseline – 31 vs 21 (GEE, p<0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11574271	To understand how RON at the cell surface transduces signals leading to the intracellular accumulation of HIF-2α in bladder cancer cells, we focused our attention on JNK and ERK signaling pathways, both pathways have been implicated in regulating HIF-2α expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	The data represent the mean ± SEM, p< 0.05, by t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "represent", "the", "mean", "±", "SEM", ",", ...
PMC2614416	Based on normalized annotation scores, oxidoreductases are decreased in HepG2 by 56%: HepG2: (oxidoreductase activity, Seqs:196 Score:124.4) :: Liver: (oxidoreductase activity, Seqs:331 Score:237.8)].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11095939	After 12 hr, the transfection medium was changed to normal medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "12", "hr", ",", "the", "transfection", "medium", "was", "changed", ...
PMC10376064	Thus, the observed activation of the ABCC1 ATPase by DMS-SG only suggests that DMS-SG (and not DMF) is the actual effector in the functional assays, being itself a substrate rather than an inhibitor of ABCC1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11471176	Samples or standards are introduced into designated wells, followed by the addition of ACE2-specific Horseradish Peroxidase (HRP)-conjugated antibodies, allowing for incubation after each addition step.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8662250	In the same experimental condition, SP promoted a parallel formation of pyroptotic bodies, increasing chromatin thickening in the cell nuclei (+307%, +603%, +826% vs. vehicle group) (Figure 1b,c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7351993	d Histograms of event rates in two sorting experiments (nominal throughput values: 50.2 eps, 85.6 eps).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Histograms", "of", ...
PMC11753435	Densitometry analysis of protein bands in immunoblots was performed using ImageJ. Intensity data for the uAb bands were normalized to band intensity for the empty plasmid control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329237	Cell migration was defined as 100% when cells were cultured with DMEM alone (non-treated control).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "migration", "was", "defined", ...
PMC11509224	These three diterpenes, macfarlandins F–H (57–59, Figure 7), were obtained from a sample of the marine sponge Chelonaplysilla sp. collected in Samoa .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8567602	Here, we show that GBAF is by far the more abundant SS18–SSX-containing BAF-family complex on synovial sarcoma chromatin, fitting the hypothesis of Brien and colleagues (31), who suggested that GBAF is the fusion-bearing complex, rather than that of Michel and colleagues (41), who suggested that GBAF is a synovial sarc...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7917457	Human melanoma A375 and SK-MEL-2 cells, human lung carcinoma A549 cells, human synovial sarcoma SW982 cells, and human TNBC HCC70 cells were infected with various amounts of VALO-D102 and PeptiCRAd-1 or left uninfected.	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11752740	To explore potential interactions between the two substances-whether synergistic, additive, or antagonistic-various concentrations were tested.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "explore", "potential", "interactions", "bet...
PMC10745221	In both the 143B-P and 143B-R cells, multiple proteins with ADMA modifications are present between approximately 175 kDa and 30 kDa at similar intensity levels.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11222184	Our findings indicate that HSP90 inhibition with XL-888 and Debio0932 reduces the expression of angiogenesis-related genes in neuroblastoma cells and has great potential for inhibiting angiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10253973	They reported binding energies for STU, FLL and E52: –66.5, –67.2 and –91.3 kJ/mol, respectively, indicating that both FLL and E52 are a promising drug candidates to limit the spread of malaria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10723784	Furthermore, when A2780/CP70 cells were treated with a combination of carboplatin plus CBD, slight synergistic effects were observed with CI values of 0.85, 0.78, 0.8, and 0.57 after 24, 48, 72, and 96 h contact times, respectively.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: We retrospectively reviewed data of patients aged over 65 years diagnosed with MM and treated at the hematology department of Hedi Chaker Hospital Sfax between January 2012 and December 2019.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6934009

Cell study.

[ { "tags": [ "O", "O", "O" ], "tokens": [ "Cell", "study", "." ] } ]

PMC11672617

The assay is a valuable tool for screening compounds and elucidating the kinetics of dose-dependent processes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "assay", "is", "a", "valuable", "tool", "f...

PMC11638255

g Concentration of copper in conditioned media before and after 30 min incubation with naive neutrophils isolated from healthy donors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Concentration", "of", ...

PMC11777207

All patients provided written and informed consent, and the study was approved by the institutional review board at the University of Colorado-Anschutz under COMIRB # 17-2159 and 06-0566.

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PMC11092382

This modulation is achieved by inhibiting the phosphorylation of JNK and p65, resulting in decreased expression of iNOS and IL-1β, thereby suppressing the production of inflammatory factors such as IL-6 and IL-1β (Wang et al., 2021a).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7642379

Genomic copy number gain (red) or loss (blue) of chromosomes 1, 8, 9, 13 and 18 of progeny HEK293 cell lines compared to parental HEK293 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...

PMC7709199

Per roller bottle (300 ml expression volume), 50 ml transfection mixture containing 500 µg DNA at a 1:1 DNA:PEI ratio in Dulbecco’s Modified Eagle’s Medium (DMEM) was used.

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PMC11772449

There are many ways to analyze and judge the interaction forms of the two drugs.

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PMC11638288

In summary, NKp46 facilitates the progression of type 1 diabetes by inducing NK cell degranulation through its interaction with the ligand, leading to the destruction of pancreatic β-cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The lack of response to corticosteroids shall induce introduction of novel therapies sooner in the treatment course of suspected ES cases.

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PMC9429973

First line treatment of tMZL was with anthracycline containing chemoimmunotherapy in 84% of cases.

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PMC8382973

Despite repeated tissue sampling and 2P23 gel treatment, the inflammatory cytokines and microbiota of the rectum and vagina remained stable.

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PMC5874706

The concentration of staurosporin used in the experiment was 0.5 µM. After 24 h and 48 h, respectively, 10 μL of the MTT solution (5 mg/mL in PBS) were added to each well and the plate was incubated for 2 h at 37 °C.

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PMC11755519

Thus, they may be responsible for forming the pre-metastatic niche.

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PMC11634027

I′,J′) Rose plots showing quantification of Dachs polarity, with distal at bottom, in Flp-out clones from the genotypes shown in I (n=161 cells from nine discs) and J (n=137 cells from ten discs).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11127909

Scale bar = 1 µm, N = 3.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "1", "µm", ",", "N", "=", "3", "." ] } ]

PMC11412721

We previously used this model to show that p53-AS isoforms had no role in the anemia affecting Trp53 mice (Simeonova et al., 2013).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC10674574

However, the data presented (Table 5) show that Caco-2 monolayers with a TERR of at least 300 ohms are commonly used for permeability studies.

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PMC9429973

Methods: The analysis included 62 patients with acute myeloid leukemia (AML, n=30) and acute lymphoblastic leukemia (ALL, n=32) who underwent haplo-HSCT at the National Medical Research Center for Hematology in the period from May 2018 to February 2021.

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PMC9776316

Moreover, in our previous study, we found that the DGKA signals through JNK-cJUN drive the transcription of WEE1, a kinase involved in DNA damage checking point response 26.

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PMC11266100

Permeabilization assay was performed for both µsPEF and nsPEF using 1.2 kV/cm and 2.5–10 kV/cm pulse amplitudes, respectively.

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PMC11792740

Future research should focus on integrating multiple therapeutic strategies to address the multifactorial nature of T-cell exhaustion, thereby enhancing the overall effectiveness of cancer immunotherapy.

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PMC11457557

However, despite these measures, many people with DKD still progress to end-stage renal disease .

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PMC9429973

Dresden, Germany; University of Rome “Cattolica S. Cuore”, Rome, Italy; Hospital Universitario y Politécnico La Fe; Instituto de Salud Carlos III (CIBERONC), Valencia, Spain; Novartis, Oncology Region Europe, Basel, Switzerland; University Hospital of Ulm; Ulm University Hospital, Ulm; Hannover Medical School, Hannover...

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PMC9672323

al indicated that aspirin and metformin induce apoptosis in 4T1 cells through an increment in TGF-β secretion by these cells.

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PMC11267830

e Body weight changes in the two preclinical leukemia mouse models.

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PMC11247842

We assigned the genotype to CNV following and treated 3 copies as 2 copies (wild type) as no cases with 3 copies were reported in and it could be an estimation error due to lower coverage in our dataset compared to the previous study .

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PMC11454015

Estrogen receptor (ER) expression and E-cadherin (CDH1) loss are the two major molecular hallmarks of invasive lobular carcinoma (ILC) of the breast; however, it is unclear how ER signaling and E-cadherin loss crosstalk during ILC tumor formation.

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PMC11281366

The following Abs were used in flow cytometry assays: BV421 anti-human CCR5 (Biolegend, #359118), PE/Cyanine7 anti-human CD4 (Biolegend, #317414) and PE anti-human CD59 (Miltenyi, #130-120-048), as well as its isotype control (Miltenyi, #130-113-438).

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PMC9786247

Identification of particular genetic determinants encoding for host adaptation and virulence was beyond the scope of this study.

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PMC2196094

A nearly full-length cDNA clone for RMCP-9 was isolated (Figs. 2 B and 5 B).

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PMC9621239

Therefore, the protein levels of CDT1 and ATM in HCC cells were assessed using Western blot assays, wherein the HCC cells stably expressing HBx-TM had higher CDT1 and ATM protein levels compared with the HCC cells stably expressing HBx-WT (Figures S9E and S9F), suggesting that the presence of DNA DSB in the HCC cell li...

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PMC11026382

For comparison, we also mapped the model-predicted catalytic power averaged across all mutations at a position to the structure (Fig. 7e).

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PMC11599565

Results are representative of n = 3 experiments.

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PMC9429973

Reductions in Ikaros/Aiolos protein levels in tumor cells were observed at all dose levels in both cohorts with a >90% reduction at the 0.45-mg dose.

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PMC11257988

Additionally, the research group conducted experiments with BI-2865 to inhibit NRAS and HRAS mutant cells, revealing that the inhibitor’s ability to inhibit nucleotide exchange in HRAS or NRAS is several orders of magnitude lower than that in KRAS, and this difference is attributed to direct and/or indirect constraints...

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PMC11064533

After the 24 h, OD600 was measured for each well with the Tecan microplate reader (Tecan, Austria).

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PMC9429973

Methods: ACTIVATE was a phase 3, global, double-blind, placebo (PBO)-controlled study of mitapivat in adults with PK deficiency who were not regularly transfused (≤4 transfusion episodes in prior year [yr]; none in prior 3 months).

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PMC9429973

To explore immunophenotic and molecular genetic markers we use three state “illness-death” model.

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PMC2944824

We suggest that the developmental changes in Hr expression explains, in part, why cell death occurs more commonly through apoptosis in the immature rat brain whereas cell death through necrosis is more commonly observed in the adult , .

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PMC9739791

The induced DNA damage and oxidative stress activate apoptosis, which leads to cell death .

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PMC10652261

As depicted in Figure 7, the percentages of caspase 3(+) K562 cells treated with compounds 2e, 2f, 2h, and bortezomib were found as 58.6, 30.1, 57.2, and 19.7%, respectively.

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PMC11098378

A. Schematic outlining screen for bacterial effectors that rescue arbovirus restriction in LD652 cells.

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PMC11469524

After applying parameter stability analysis using profile likelihood, we noted that of the 15 shared links only 2 (AKT->BAD, MEK->ERK) are not significantly different (i.e., 95% confidence intervals do not overlap; S2 Table).

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PMC9046263

p < 0.05.

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PMC11628904

Quantification of burn depth over time with the indicated treatment.

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PMC11489351

Notch1 reporter fluorescence is shown in intensiometric display, and nuclei were stained with Hoechst dye (DAPI).

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PMC11277157

Only evidence of physical interactions was included .

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PMC11087301

Moreover, leptin signaling has been found to elevate cell viability, migratory and invading abilities, and CSC- and EMT-correlated gene expression in breast cancer.

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PMC9545714

Likewise, TNF‐α is not upregulated at 6 h, but TNFIP3 (TNF α‐induced protein 3) is upregulated indicating the TNF gene was upregulated earlier.

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PMC11365427

Each sample was mixed for quality control (QC) with the same pretreatment as the study samples.

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PMC11635087

Although the maintenance of photosynthetic activity in isolated chloroplasts in vitro has been reported, our study is the first to measure the photosynthetic activity of chloroplasts in mammalian cells.

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PMC11794847

Single-cell data were sourced from the Tumor Immune Single-cell Hub (TISCH).

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PMC9429973

Impact on PB and EB was higher in MF and PV as compared to ET: PB = 28.6 and 21.4 vs 14.3; EB = 31.8 and 27.3 vs 22.7, respectively.

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PMC11098378

One exception to this trend was human RNF214, which was dramatically reduced in level when co-expressed with GFP-IpaH4 (S4B Fig).

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PMC9429973

The type of functional impact of each mutation depends on the protein region where the replacement occurs Image: Summary/Conclusion: Clinical studies and structural bioinformatics should work together towards precision medicine.

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PMC6892818

Therefore, although mCD40L induces extensive apoptosis in malignant (RCC) cells, normal cells remain totally refractory to mCD40L.

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PMC7504302

Taken together, further studies may provide the basis for assessing TGF-β pathway-specific inhibitors for targeted therapy in MPM, at least in those with high EMT scores.

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PMC9429973

Efficacy and toxicity in our cohort are comparable with ZUMA-1 study results and other large real world cohorts.

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PMC11756514

An example is the recognition of unusual patterns of surface carbohydrates on microorganisms by carbohydrate-binding proteins of the host.

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PMC11761919

4Detection of humoral and cellular immune responses to oral immunization with microsphere containing Fiber2-expressing E. faecalis plus PINs or inulin.

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PMC10748106

Among natural products, iridoids have shown different biological activities, including cytotoxic and antitumor effects, in different cancer cell types.

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PMC11754291

While lower intensities preserved metabolic activity and α-MSH production at baseline levels, intermediate intensity (10 mW/cm, 15 J/cm) optimally stimulated α-MSH production with minimal cytotoxic effects.

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PMC10734950

In conclusion, DNA fragmentation was evident upon the treatment of F8 on the CCRF-CEM cell line after 72 hours.

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PMC10890055

We also prepared extracts of Zn-based biomaterials and tested the cytotoxicity of these extracts on the two cell types.

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PMC5810978

We did not verify our results by other methods (e.g. nonstructural protein expression, dsRNA detection, (-) strand RNA detection, etc).

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PMC11655498

In summary, these cellular factors can directly bind to Zp and Rp or recruit other factors for binding, thereby modulating their transcription activity and initiating subsequent processes in EBV reactivation.

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PMC11420784

The prototypic FYVE protein is EEA1, which is the early endosomal autoantigen that mediates early endosome fusion .

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PMC10656496

Another way to conceptualize these cell lines is that 143B is a “cream skimmer” that is more fit in times of optimal environmental conditions while SAOS2 is a “crumb picker” able to adapt to suboptimal conditions, including chemotherapeutic selection, and thus increases fitness relative to 143B at suboptimal times.

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PMC11535726

Scale bars: 100 μm (c, d); 20 μm (e–l).

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PMC10587429

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

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PMC5941560

Yearly publication counts for PubMed queries.

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PMC11394386

Recently, the role of long non-coding RNAs (LncRNAs) as essential effectors of signaling pathways in cancer development has been extensively explored.

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PMC10291556

The uptake of the platinum complexes by HeLa cells was determined as the platinum amount per 10 cells.

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PMC8956657

Numbers next to nodes indicate bootstrap proportion support, and the scale indicates the number of nucleotide substitutions per site.

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PMC11597167

CT values were exported from the BioRad CFX Connect real-time qPCR system and normalized against a reference gene.

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PMC11683130

In general, neutrophils play an important role in the initiation and maintenance of psoriasis through ROS production, degranulation and NET formation.

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PMC8592717

Basil (Ocimum basilicum), lemon thyme (Thymus citriodorus), and mint (Mentha sp.), belonging to the mint family, which are used as culinary herbs in many countries, contain many antioxidant and anti-inflammatory phenolic compounds such as PCA and PAL among others [23-26].

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PMC11365983

We demonstrate that altering the level of Foxc1 protein, via shRNA mediated inhibition, CRISPR/Cas9 mutagenesis and overexpression, modifies cilia length in vitro.

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PMC8759873

Research has found that the VHL gene-hypoxia-inducible factor-hypoxia response gene pathway (VHL-HIF-HRG pathway) plays an important role in kidney cancer.

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PMC9429973

Total ESAS-R score decreased by 10 points at 18 mos of therapy as compared to baseline – 31 vs 21 (GEE, p<0.05).

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PMC11574271

To understand how RON at the cell surface transduces signals leading to the intracellular accumulation of HIF-2α in bladder cancer cells, we focused our attention on JNK and ERK signaling pathways, both pathways have been implicated in regulating HIF-2α expression .

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PMC11453018

The data represent the mean ± SEM, p< 0.05, by t-test.

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PMC2614416

Based on normalized annotation scores, oxidoreductases are decreased in HepG2 by 56%: HepG2: (oxidoreductase activity, Seqs:196 Score:124.4) :: Liver: (oxidoreductase activity, Seqs:331 Score:237.8)].

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PMC11095939

After 12 hr, the transfection medium was changed to normal medium.

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PMC10376064

Thus, the observed activation of the ABCC1 ATPase by DMS-SG only suggests that DMS-SG (and not DMF) is the actual effector in the functional assays, being itself a substrate rather than an inhibitor of ABCC1.

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PMC11471176

Samples or standards are introduced into designated wells, followed by the addition of ACE2-specific Horseradish Peroxidase (HRP)-conjugated antibodies, allowing for incubation after each addition step.

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PMC8662250

In the same experimental condition, SP promoted a parallel formation of pyroptotic bodies, increasing chromatin thickening in the cell nuclei (+307%, +603%, +826% vs. vehicle group) (Figure 1b,c).

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PMC7351993

d Histograms of event rates in two sorting experiments (nominal throughput values: 50.2 eps, 85.6 eps).

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PMC11753435

Densitometry analysis of protein bands in immunoblots was performed using ImageJ. Intensity data for the uAb bands were normalized to band intensity for the empty plasmid control.

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PMC10329237

Cell migration was defined as 100% when cells were cultured with DMEM alone (non-treated control).

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PMC11509224

These three diterpenes, macfarlandins F–H (57–59, Figure 7), were obtained from a sample of the marine sponge Chelonaplysilla sp. collected in Samoa .

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PMC8567602

Here, we show that GBAF is by far the more abundant SS18–SSX-containing BAF-family complex on synovial sarcoma chromatin, fitting the hypothesis of Brien and colleagues (31), who suggested that GBAF is the fusion-bearing complex, rather than that of Michel and colleagues (41), who suggested that GBAF is a synovial sarc...

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PMC7917457

Human melanoma A375 and SK-MEL-2 cells, human lung carcinoma A549 cells, human synovial sarcoma SW982 cells, and human TNBC HCC70 cells were infected with various amounts of VALO-D102 and PeptiCRAd-1 or left uninfected.

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PMC11752740

To explore potential interactions between the two substances-whether synergistic, additive, or antagonistic-various concentrations were tested.

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PMC10745221

In both the 143B-P and 143B-R cells, multiple proteins with ADMA modifications are present between approximately 175 kDa and 30 kDa at similar intensity levels.

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PMC11222184

Our findings indicate that HSP90 inhibition with XL-888 and Debio0932 reduces the expression of angiogenesis-related genes in neuroblastoma cells and has great potential for inhibiting angiogenesis.

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PMC10253973

They reported binding energies for STU, FLL and E52: –66.5, –67.2 and –91.3 kJ/mol, respectively, indicating that both FLL and E52 are a promising drug candidates to limit the spread of malaria.

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PMC10723784

Furthermore, when A2780/CP70 cells were treated with a combination of carboplatin plus CBD, slight synergistic effects were observed with CI values of 0.85, 0.78, 0.8, and 0.57 after 24, 48, 72, and 96 h contact times, respectively.

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