OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	Pretreatment of mice with 14E1 markedly ameliorated vaso-occlusion and reduced both C3b and C5b-9 deposition on RBCs, and hemolysis biomarkers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pretreatment", "of", ...
PMC9509578	are substrates of both CYP3A4 and P-gp [187–190].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "are", "substrates", "of", "both", "CYP3A4", "and", "P-gp", "[", "187–190", "]", "." ] ...
PMC9532503	Afucosylation is a post-translational modification that does not require any modification in the genetic sequence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Afucosylation", "is", "a", "post-translational", "modification", ...
PMC9856122	Later the same researcher evaluated subtypes of isoquinoline alkaloids obtained from water and methanolic extract of Chinese medicinal plants by subjecting them to plaque reduction assay to investigate the anti-HSV activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9681981	Conventional PCRs for cpa , etx , and 16S rRNA genes To evaluate the accuracy of cDNA and primer synthesis, conventional PCRs for cpa, etx, and 16S rDNA genes were performed in a final volume of 25 μL consisting of 12.5 μL of Master Mix (Ampliqon), 1 μL of each primer (10 μM), 2 μL of cDNA, and 8.5 μL of distilled wate...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	Despite the discovery of feedbacks and crosstalks in ERK and p38 signaling we could not find a cellular dependency in the cell lines we studied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9684669	Collectively, these findings suggest that the calcium signaling pathway is associated with the MDR phenotype in the A2780-ADR cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Collectively", ",", ...
PMC11509278	The mixture was filtered under vacuum after incubation at room temperature for 48 h, and then it was centrifuged at 8000× g for 10 min at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	The cell lysates were immunoprecipitated by using anti-Flag antibody and then immunoprecipitates were subjected to immunoblotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "lysates", "were", "immunoprecipitated", ...
PMC11604768	Likewise, the Mafb motif (TGCTGACGTAAGCA) in the TRE-MPRA library contains a sequence very similar to the cAMP responsive element (TGACGTCA) and so may be activated by cAMP responsive element binding protein 1 (CREB1) as opposed to MAFB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10882807	Recently, knowledge of RBPs has increased substantially owing to the development of new technologies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "knowledge", "of", "RBPs", "has", "increase...
PMC11380454	This shift results in the secretion of cytokines such as IL-2 and interferon-gamma, which potentiate the proliferation and enhance the function of CTLs 27.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10565698	However, no significant variation was observed in the MUT group (Fig. 6H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "no", "significant", "variation", "was", "ob...
PMC11765988	When antigens are encountered, they are phagocytosed and presented by cells like macrophages or dendritic cells to CD4+ T helper cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", ...
PMC9583612	Measurement approaches should be based on basin-specific characteristics of methane emissions, but the key to effective mitigation is the ability to independently verify emissions estimates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11186948	Membranes were washed with TBS (TBS 1x diluted from 10x made of 3% Tris HCl, 8,7% NaCl and 0,2% KCl) supplemented with 0.1% Tween (TBS-T), blocked for 1 h at RT with 5% milk in TBS-T and then with primary antibody diluted in blocking solution for 1 h at RT (rabbit anti-H3, 1:10000, ab1791 Abcam, RRID: AB_302613; rabbit...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	These peaks are likely connected with specific components, such as aromatic structures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "peaks", "are", "likely", "connected", "with", "specific", "compone...
PMC11705862	Similarly, IRIS-2 protein levels were higher in differentiated cells, as shown by Western blotting (n = 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", ...
PMC7841189	The results showed that knockdown of LTBP2 inhibited migration of FTC133 cells, compared with the mock group (Fig. 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11672881	The principal component analysis (PCA) performed on all samples showed that the groups were tightly clustered in the PCA score plot, indicating clear distinctions among the treatments (Figure stheir combination had strong effects, resulting in significant metabolic variations in A375 cells (Figure 8B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759543	Although vorinostat exhibits cytotoxicity in cell assays (Fig. 1B), it does not have an anti-tumor effect in vivo (Fig. 8A–C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11172027	Here, in contrast to the results on MTC-SK cells, NALM and NASeLM both minimized mitochondrial activity and cell growth, but there was no difference between methionine and the selenium-containing methionine substance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8481254	Data are shown as mean ± SD. **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "±", "SD", ".", "", "" ] } ]
PMC11684297	We have assessed the in vivo toxicity of the as-synthesized ZnO-NFs where 30 embryos in each group (control, ZnO-NF-25 µg/ml, ZnO-NF-100 µg/ml, and ZnO-NF-200 µg/ml), was taken and monitored under a light microscope until they hatched according to Deepika et al. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	Whether ORF4b inhibition of IRF3 and IRF7-mediated IFNβ induction (as suggested within the literature) occurs via an analogous mechanism remains to be explored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6487404	Analysis of the samples HPLC was conducted using a system consisting of a Wellchrom K-1001 HPLC pump and a K-2700 diode array UV/VIS spectrophotometric detector (Knauer, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Included patients were residents of Ontario aged ≥18 years with an MPN diagnosis from Jan 1, 2004 to Dec 31, 2019.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Include...
PMC8916024	Function prediction revealed significantly better biochemical function in the snail gut than sediments (P < 0.001), but no significant differences in adult and juvenile snail (P > 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	P value less than 0.05 is considered as the cutoff criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "value", "less", "than", "0.05", "is", "considered", "as", "the", "cutoff", ...
PMC11499381	Even when statistical analysis gave a significant difference, the changes in cell surface expression were modest and not likely to affect cell signaling .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6461034	Put a 15‐ml tube with lysate on ice just before sonication (urea will precipitate out after prolonged cooling).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Put", "a", "15‐ml", "t...
PMC10988808	Renal cell carcinoma (RCC) is a common clinical malignancy of the urinary system, accounting for approximately 90% of kidney cancers tumor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11720808	α-tubulin and Lamin B1 were used as internal markers for the cytoplasm and nucleus, respectively. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "α-tubulin", "and", "Lamin", "B1", "were", "...
PMC11730000	EGCG is an inhibitor of both the PI3K and mTOR pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EGCG", "is", "an", "inhibitor", "of", "both", "the", "PI3", "K", "and", ...
PMC11574029	Conversely, NOTCH3 overexpression increased luciferase activity in cells with WT SPP1, whereas but not of those with mutated SPP1(Supplementary Fig. S2H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11224206	Repeat this analysis for the gametes in their environments in the male and female reproductive tracts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Repeat", "this", "analysis", "for", "the", "gametes", ...
PMC9429973	No case has had disease progression after achieving an initial response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "case", "has", "had", "disease", "progression", "after", "achieving", "an", "ini...
PMC11371627	Sanger sequencing of the XK gene revealed a novel deletion at position 756, resulting in a frameshift deletion and a premature termination of the amino acid chain (exon 3; c.756del, p.Trp253Glyfs*15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10222971	A wide range of biological activities have been described highlighting their cytotoxic activity, gaining the attention of researchers in recent years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "wide", ...
PMC9792775	The data were analyzed with GraphPad Prism software version 6.00 for Windows (La Jolla, CA). *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "were", "analyzed",...
PMC9512971	Baseline characteristics were analyzed using descriptive statistics, including numbers (proportions) of patients and summary statistics, as appropriate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Baseline", "characteris...
PMC9243326	Currently, single-molecule real-time (SMRT) long-read sequencing technology based on PacBio platform is the most reliable full-length cDNA molecular sequencing method, which can truly reflect the transcriptome information of the sequenced species and is conducive to the study of variable splicing, gene fusion, alleles ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11228511	A similar approach was used to generate SMCs expressing Dox-inducible constructs for LAP2β.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "similar", "approach", "was", "used", "to", "generate", "SMCs", "...
PMC11643491	The graph depicting the AR distribution exhibits a rightward shift for the stretched particles, with a more pronounced shift observed for the stretch ratio of 1.3 compared to the stretch ratios of 1.0–1.2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11424574	Using siRNA-ERK to block endogenous ERK1/2 expression in HOS cells, we observed a decrease in the increased expression of uPA induced by MTA2 depletion (Figure 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543885	The biotin-phenoxyl radicals quickly interact with nearby electron-rich amino acids, particularly tyrosine (tryptophan and cysteine in some cases).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "biotin-phenoxyl"...
PMC11766332	Beyond their diagnostic potential, these miRNAs could also serve as therapeutic targets as supported by the emerging literature .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Beyond", "their", "diagnostic", "...
PMC6627640	Consistent with the upregulation in expression of genes normally repressed by PRC1/PRC2, the PRC2-mediated repressive mark H3K27me3 was consistently downregulated in the resistant cells as was the PRC1 repressive mark H2A-K119Ub (Figure 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	Although Fuest and colleagues did not recorded SK1 currents in ES cells , our work have shown that KCNN1 silencing leads to membrane depolarization in a 2D and 3D cell models, and to a decrease in both SOCE and CCE, suggesting a mechanism of action according to the second hypothesis without excluding the third one.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	The eclipse and release periods are therefore critically dependent on the OV life cycle in its CC and unique for every specific CC/OV combination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11194678	STAU1 LLPS enhances mTOR signaling and impairs autophagy flux in HD cell line. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "STAU1", "LLPS", "enhances", "mTOR", "signaling", "and", "impairs", ...
PMC9622879	Motivated by the above works, we propose a community with a system-centric CEMS that supports different types of homes with individual DERs: homes with both an RES and ESS, homes with an individual RES only or individual ESS only, and homes without an RES or ESS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients received a median of three cycles of TQB3602 (range 1-11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "received", "a", "median", "of", "three", "cycle...
PMC6312945	The proliferation of BEL-7404 cells in BEL-7404 pSUPER.neo-miR-101 group was significantly lower than that in BEL-7404 pSUPER.neo-101 group (P<0.05) by MTT assay, and showed a gradual downward trend.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11724582	Mutations affecting the epidermal growth factor receptor (EGFR) gene are prevalent functional gene alterations in NSCLC, particularly in Asian populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutatio...
PMC11607321	The SHAP calculation was performed in two ways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "SHAP", "calculation", "was", "performed", "in", "two", "ways", "." ] } ]
PMC11720107	In the SCC-15 cell line, extracts from the Harnaś and Ornak cultivars increased CAT protein expression by 5.4 ng/mL and 11.1 ng/mL, respectively, compared with the control (Figure 8C).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5535901	When activated, T-cells also produce a broad range of cytokines and chemokines that are important in immune cell recruitment and in regulation of inflammatory responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7081114	We first assessed the differential expression of KIF21B using the Cancer Genome Atlas (TCGA) database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "assessed", "the", "differential", ...
PMC11462673	Unfortunately, we primarily conducted experiments using T-ALL cell lines and have not yet undertaken studies involving transgenic mice, PDX models, or spontaneous model experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	Following co-treatment with different concentrations of quercetin and MST-312, cell viability was determined using alamar blue assay. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "co-treatment", "with", ...
PMC11768927	Although overcoming resistance remains a significant challenge, promising strategies involve the use of agents that inhibit innate immune responses in cancer cells, such as ruxolitinib (JAK1/2 inhibitor).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184	Statistically significant difference, with p < 0.05, is observed only at 1250 V/cm between CTRL and EP group of 15 generation in experiment 1.Figure 3Survival at different electric fields for 15 generation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9960565	However, in the case of G1.5(COOPt(NH3)2Cl)16, the fluorescence increased, making the fluorescence significantly higher than that shown by the other two metallodendrimers (Figure S26b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	Then cancer cells were stained with FITC-conjugated anti-CD133 antibody, PE-conjugated anti-CD44 antibody and FITC-conjugated anti-CXCR4 antibody, respectively, for 30 min on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11721064	The reporting of animal experiments in this study adhered to the ARRIVE guidelines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reporting", "of", "animal", "experiments", "in", "this", "study", ...
PMC9429973	The ektacytometric study was performed using the osmoscan module of the Lorca ektacytometer (MaxSis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ektacytometric", "study", "was", "performed", "using", ...
PMC7553912	The isotype controls are shown as red dots (upper panels) and red areas (middle and lower panels). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "isoty...
PMC11122631	So far, all prostanoids isolated from Clavularia with an acetoxy substitution on C-12 were identified as being the S configuration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", "far", ",", ...
PMC11743414	C Cell Counting Kit-8 was used to detect the effect of Ara-C and DNR different concentrations on cell proliferation underthe overexpressed FHL1Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Cell", ...
PMC11422497	circ_SMA4 promoted cell proliferation, invasion, migration, while inhibiting apoptosis in GISTs cells, both in vitro and in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "circ_SMA4", ...
PMC9429973	Results: We identified 67 pts with APL during the study period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "identified", "67", "pts", "with", "APL", "during", "...
PMC10808409	A possible explanation to the low CMC value of the TPGS mixed micelles could be due to attributed to the addition of TPGS, which provided more hydrophobic moiety to the micelles, thus allowing micellization to occur at a lower CMC value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11714165	After staining, optical microscopy was used to examine the sections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "staining", ",", "optical", "microscopy", "was", "used", "to", "examine", "th...
PMC11509224	The compound hamigeran M (124) represents the first instance of a non-benzo-fused, oxazole-containing terpenoid isolated from the marine environment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compo...
PMC11741906	For A2780cis resistance maintenance, culture media was supplemented with 1 μM of cisplatin (Sigma-Aldrich, USA) every three passages.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC11544771	This is supported by the findings that co-treatment with CPX and PRE for 24 h increased the protein expression of DR4, DR5, Fas, and FADD (Figure 6A,B and Figure S4A,B), leading to activation of caspase 8, as detected by increased level of cleaved caspase 8 (Figure 5D,E and Figure S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445	It was also found that the complex (80a) adopted distorted octahedral geometry having one acyl thiourea ligand coordinated to the metal ion through S and O atoms, two chloride ions at the equatorial position, and two PPh3 at the axial position in solid state structure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087766	All cells imaged per each condition were quantified to avoid bias.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cells", "imaged", "per", "each", "condition", "were", "quantified", "to", "avo...
PMC11701801	D, Weight of tumor xenografts derived from SS18–SSX fusion Fuji cell lines and harvested from mice treated once daily with 30 mg/kg CP-C27.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11767582	This reaction gave rise to the desired 1,5-disubstituted triazoles with complete regioselectivity in moderate to good yields (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "reaction", ...
PMC11657744	Scale bars, 200 nm Immunofluorescent staining of NIH3T3 cells incubated in serum-free media with an acetylated tubulin antibody further confirmed the differential effect of DA proteins on ciliary assembly (Fig. 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7090062	Thus, further investigations into the possible mechanisms responsible for IM resistance in GISTs and the identification of novel therapeutic targets to overcome this chemotherapy resistance are urgently required.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Hierarchical clustering of the cell lines based on SNVs gave a slightly different trend compared to the transcriptomic comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hierarchical", "clustering", "of", ...
PMC4816271	Whilst this toxicity could be considered relatively mild, more severe and even fatal incidences have been subsequently documented.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whilst", "this", "toxicity", "cou...
PMC11770130	In addition, the serum C20–C24 ceramide levels were positively correlated to body weight, fat mass, body mass index, blood glucose level, serum triglyceride level, serum total cholesterol level, and serum low-density lipoprotein cholesterol for the adults (Supplementary information, Fig. S10), though the correlations b...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	Cold shock alone did not affect the expression of WWOX, TRAF2 and α-tubulin (Fig. 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cold", "shock", "alone", "did", "not",...
PMC9429973	Methods: This was a retrospective, observational cohort study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "This", "was", "a", "retrospective", ",", "observational", "cohort", "study", ...
PMC10170482	Also, the pathological development of many diseases is associated with changes of values in stiffness, viscosity, curvature, and ECM architecture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11575040	To conduct a clonogenic assay, 1 × 10 live cells were deposited onto a six-well plate and transfected with LINC00094 siRNA (LINC00094-2 or si-LINC00094-3), miR-1270 mimics, or scramble control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680578	< 0.001 as compared to that of the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "<", "0.001", "as", "compared", "to", "that", "of", "the", "control", "." ] } ]
PMC11345828	Briefly, a previously reported construct was subcloned into an expression vector (pDEST-HisMBP) expressed in Escherichia coli BL21 CodonPlus (DE3) RIL (Stratagene) and purified through nickel-column and size-exclusion chromatography sequentially.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	Hence, to devise synergistic drug combinations for these five basal BC cell lines, additional perturbations targeting various components of the RAS-RAF-MEK-ERK signaling cascade are necessary, which are absent in the existing dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7153288	Genome sequence comparison was performed by BBMap's MinHash Sketch program.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genome", "sequence", "comparison", "was", "performed", "by", "BBMap", "'s", "MinHash", ...
PMC11290772	The NK cells were then stimulated to mature using interleukin-2 (IL-2) and subsequently harvested.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NK", "cells", "were", "then", "stimulated", ...
PMC11098378	Ceg10 was concentrated to 2.5 ml using a 10,000 MWCO Amicon 50 spin concentrator, subjected to centrifugation at 40,000 rpm (TLA55 rotor), and further purified using a Superdex highload 200 16/600 gel filtration chromatography column (Cytiva Life Sciences).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: During the treatment with imatinib 400mg in I TL, 2/3 of patients achieved and maintained CCyR. Patients with achieved CCyR had significantly longer survival and 54% of patients achieved at least deep molecular response (MR4.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600592	Other peptides specifically bound to the HLA-A2 residue activate CTL responds to prevent infection and eliminate HBV .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "peptides", "specifically", "bound", "to"...
PMC9424261	Representative images of IB are shown in the figure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "IB", "are", "shown", "in", "the", "figure", "." ] } ]
PMC11742290	High LGR5 protein expression has also been associated with poor outcome and recurrence in cancers of the brain , lung , esophagus , breast , colon [11, 52–54], cervix and ovary .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Pretreatment of mice with 14E1 markedly ameliorated vaso-occlusion and reduced both C3b and C5b-9 deposition on RBCs, and hemolysis biomarkers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pretreatment", "of", ...

PMC9509578

are substrates of both CYP3A4 and P-gp [187–190].

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PMC9532503

Afucosylation is a post-translational modification that does not require any modification in the genetic sequence.

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PMC9856122

Later the same researcher evaluated subtypes of isoquinoline alkaloids obtained from water and methanolic extract of Chinese medicinal plants by subjecting them to plaque reduction assay to investigate the anti-HSV activity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9681981

Conventional PCRs for cpa , etx , and 16S rRNA genes To evaluate the accuracy of cDNA and primer synthesis, conventional PCRs for cpa, etx, and 16S rDNA genes were performed in a final volume of 25 μL consisting of 12.5 μL of Master Mix (Ampliqon), 1 μL of each primer (10 μM), 2 μL of cDNA, and 8.5 μL of distilled wate...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11469524

Despite the discovery of feedbacks and crosstalks in ERK and p38 signaling we could not find a cellular dependency in the cell lines we studied.

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PMC9684669

Collectively, these findings suggest that the calcium signaling pathway is associated with the MDR phenotype in the A2780-ADR cells.

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PMC11509278

The mixture was filtered under vacuum after incubation at room temperature for 48 h, and then it was centrifuged at 8000× g for 10 min at 4 °C.

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PMC11461874

The cell lysates were immunoprecipitated by using anti-Flag antibody and then immunoprecipitates were subjected to immunoblotting.

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PMC11604768

Likewise, the Mafb motif (TGCTGACGTAAGCA) in the TRE-MPRA library contains a sequence very similar to the cAMP responsive element (TGACGTCA) and so may be activated by cAMP responsive element binding protein 1 (CREB1) as opposed to MAFB.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10882807

Recently, knowledge of RBPs has increased substantially owing to the development of new technologies .

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PMC11380454

This shift results in the secretion of cytokines such as IL-2 and interferon-gamma, which potentiate the proliferation and enhance the function of CTLs 27.

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PMC10565698

However, no significant variation was observed in the MUT group (Fig. 6H).

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PMC11765988

When antigens are encountered, they are phagocytosed and presented by cells like macrophages or dendritic cells to CD4+ T helper cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", ...

PMC9583612

Measurement approaches should be based on basin-specific characteristics of methane emissions, but the key to effective mitigation is the ability to independently verify emissions estimates.

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PMC11186948

Membranes were washed with TBS (TBS 1x diluted from 10x made of 3% Tris HCl, 8,7% NaCl and 0,2% KCl) supplemented with 0.1% Tween (TBS-T), blocked for 1 h at RT with 5% milk in TBS-T and then with primary antibody diluted in blocking solution for 1 h at RT (rabbit anti-H3, 1:10000, ab1791 Abcam, RRID: AB_302613; rabbit...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11680562

These peaks are likely connected with specific components, such as aromatic structures.

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PMC11705862

Similarly, IRIS-2 protein levels were higher in differentiated cells, as shown by Western blotting (n = 6).

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PMC7841189

The results showed that knockdown of LTBP2 inhibited migration of FTC133 cells, compared with the mock group (Fig. 3A).

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PMC11672881

The principal component analysis (PCA) performed on all samples showed that the groups were tightly clustered in the PCA score plot, indicating clear distinctions among the treatments (Figure stheir combination had strong effects, resulting in significant metabolic variations in A375 cells (Figure 8B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11759543

Although vorinostat exhibits cytotoxicity in cell assays (Fig. 1B), it does not have an anti-tumor effect in vivo (Fig. 8A–C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11172027

Here, in contrast to the results on MTC-SK cells, NALM and NASeLM both minimized mitochondrial activity and cell growth, but there was no difference between methionine and the selenium-containing methionine substance.

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PMC8481254

Data are shown as mean ± SD. **

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PMC11684297

We have assessed the in vivo toxicity of the as-synthesized ZnO-NFs where 30 embryos in each group (control, ZnO-NF-25 µg/ml, ZnO-NF-100 µg/ml, and ZnO-NF-200 µg/ml), was taken and monitored under a light microscope until they hatched according to Deepika et al. .

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PMC8956657

Whether ORF4b inhibition of IRF3 and IRF7-mediated IFNβ induction (as suggested within the literature) occurs via an analogous mechanism remains to be explored.

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PMC6487404

Analysis of the samples HPLC was conducted using a system consisting of a Wellchrom K-1001 HPLC pump and a K-2700 diode array UV/VIS spectrophotometric detector (Knauer, Germany).

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PMC9429973

Included patients were residents of Ontario aged ≥18 years with an MPN diagnosis from Jan 1, 2004 to Dec 31, 2019.

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PMC8916024

Function prediction revealed significantly better biochemical function in the snail gut than sediments (P < 0.001), but no significant differences in adult and juvenile snail (P > 0.05).

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PMC11607764

P value less than 0.05 is considered as the cutoff criteria.

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PMC11499381

Even when statistical analysis gave a significant difference, the changes in cell surface expression were modest and not likely to affect cell signaling .

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PMC6461034

Put a 15‐ml tube with lysate on ice just before sonication (urea will precipitate out after prolonged cooling).

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PMC10988808

Renal cell carcinoma (RCC) is a common clinical malignancy of the urinary system, accounting for approximately 90% of kidney cancers tumor .

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PMC11720808

α-tubulin and Lamin B1 were used as internal markers for the cytoplasm and nucleus, respectively. (

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PMC11730000

EGCG is an inhibitor of both the PI3K and mTOR pathways.

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PMC11574029

Conversely, NOTCH3 overexpression increased luciferase activity in cells with WT SPP1, whereas but not of those with mutated SPP1(Supplementary Fig. S2H).

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PMC11224206

Repeat this analysis for the gametes in their environments in the male and female reproductive tracts.

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PMC9429973

No case has had disease progression after achieving an initial response.

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PMC11371627

Sanger sequencing of the XK gene revealed a novel deletion at position 756, resulting in a frameshift deletion and a premature termination of the amino acid chain (exon 3; c.756del, p.Trp253Glyfs*15).

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PMC10222971

A wide range of biological activities have been described highlighting their cytotoxic activity, gaining the attention of researchers in recent years.

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PMC9792775

The data were analyzed with GraphPad Prism software version 6.00 for Windows (La Jolla, CA). *

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PMC9512971

Baseline characteristics were analyzed using descriptive statistics, including numbers (proportions) of patients and summary statistics, as appropriate.

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PMC9243326

Currently, single-molecule real-time (SMRT) long-read sequencing technology based on PacBio platform is the most reliable full-length cDNA molecular sequencing method, which can truly reflect the transcriptome information of the sequenced species and is conducive to the study of variable splicing, gene fusion, alleles ...

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PMC11228511

A similar approach was used to generate SMCs expressing Dox-inducible constructs for LAP2β.

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PMC11643491

The graph depicting the AR distribution exhibits a rightward shift for the stretched particles, with a more pronounced shift observed for the stretch ratio of 1.3 compared to the stretch ratios of 1.0–1.2.

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PMC11424574

Using siRNA-ERK to block endogenous ERK1/2 expression in HOS cells, we observed a decrease in the increased expression of uPA induced by MTA2 depletion (Figure 5B).

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PMC11543885

The biotin-phenoxyl radicals quickly interact with nearby electron-rich amino acids, particularly tyrosine (tryptophan and cysteine in some cases).

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PMC11766332

Beyond their diagnostic potential, these miRNAs could also serve as therapeutic targets as supported by the emerging literature .

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PMC6627640

Consistent with the upregulation in expression of genes normally repressed by PRC1/PRC2, the PRC2-mediated repressive mark H3K27me3 was consistently downregulated in the resistant cells as was the PRC1 repressive mark H2A-K119Ub (Figure 3B).

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PMC11706776

Although Fuest and colleagues did not recorded SK1 currents in ES cells , our work have shown that KCNN1 silencing leads to membrane depolarization in a 2D and 3D cell models, and to a decrease in both SOCE and CCE, suggesting a mechanism of action according to the second hypothesis without excluding the third one.

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PMC10976516

The eclipse and release periods are therefore critically dependent on the OV life cycle in its CC and unique for every specific CC/OV combination.

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PMC11194678

STAU1 LLPS enhances mTOR signaling and impairs autophagy flux in HD cell line. (

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PMC9622879

Motivated by the above works, we propose a community with a system-centric CEMS that supports different types of homes with individual DERs: homes with both an RES and ESS, homes with an individual RES only or individual ESS only, and homes without an RES or ESS.

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PMC9429973

Patients received a median of three cycles of TQB3602 (range 1-11).

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PMC6312945

The proliferation of BEL-7404 cells in BEL-7404 pSUPER.neo-miR-101 group was significantly lower than that in BEL-7404 pSUPER.neo-101 group (P<0.05) by MTT assay, and showed a gradual downward trend.

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PMC11724582

Mutations affecting the epidermal growth factor receptor (EGFR) gene are prevalent functional gene alterations in NSCLC, particularly in Asian populations.

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PMC11607321

The SHAP calculation was performed in two ways.

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PMC11720107

In the SCC-15 cell line, extracts from the Harnaś and Ornak cultivars increased CAT protein expression by 5.4 ng/mL and 11.1 ng/mL, respectively, compared with the control (Figure 8C).

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PMC5535901

When activated, T-cells also produce a broad range of cytokines and chemokines that are important in immune cell recruitment and in regulation of inflammatory responses.

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PMC7081114

We first assessed the differential expression of KIF21B using the Cancer Genome Atlas (TCGA) database.

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PMC11462673

Unfortunately, we primarily conducted experiments using T-ALL cell lines and have not yet undertaken studies involving transgenic mice, PDX models, or spontaneous model experiments.

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PMC9596868

Following co-treatment with different concentrations of quercetin and MST-312, cell viability was determined using alamar blue assay. (

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PMC11768927

Although overcoming resistance remains a significant challenge, promising strategies involve the use of agents that inhibit innate immune responses in cancer cells, such as ruxolitinib (JAK1/2 inhibitor).

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PMC7305184

Statistically significant difference, with p < 0.05, is observed only at 1250 V/cm between CTRL and EP group of 15 generation in experiment 1.Figure 3Survival at different electric fields for 15 generation.

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PMC9960565

However, in the case of G1.5(COOPt(NH3)2Cl)16, the fluorescence increased, making the fluorescence significantly higher than that shown by the other two metallodendrimers (Figure S26b).

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PMC4355729

Then cancer cells were stained with FITC-conjugated anti-CD133 antibody, PE-conjugated anti-CD44 antibody and FITC-conjugated anti-CXCR4 antibody, respectively, for 30 min on ice.

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PMC11721064

The reporting of animal experiments in this study adhered to the ARRIVE guidelines.

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PMC9429973

The ektacytometric study was performed using the osmoscan module of the Lorca ektacytometer (MaxSis.

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PMC7553912

The isotype controls are shown as red dots (upper panels) and red areas (middle and lower panels). (

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PMC11122631

So far, all prostanoids isolated from Clavularia with an acetoxy substitution on C-12 were identified as being the S configuration.

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PMC11743414

C Cell Counting Kit-8 was used to detect the effect of Ara-C and DNR different concentrations on cell proliferation underthe overexpressed FHL1Fig.

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PMC11422497

circ_SMA4 promoted cell proliferation, invasion, migration, while inhibiting apoptosis in GISTs cells, both in vitro and in vivo.

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PMC9429973

Results: We identified 67 pts with APL during the study period.

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PMC10808409

A possible explanation to the low CMC value of the TPGS mixed micelles could be due to attributed to the addition of TPGS, which provided more hydrophobic moiety to the micelles, thus allowing micellization to occur at a lower CMC value.

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PMC11714165

After staining, optical microscopy was used to examine the sections.

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PMC11509224

The compound hamigeran M (124) represents the first instance of a non-benzo-fused, oxazole-containing terpenoid isolated from the marine environment.

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PMC11741906

For A2780cis resistance maintenance, culture media was supplemented with 1 μM of cisplatin (Sigma-Aldrich, USA) every three passages.

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PMC11544771

This is supported by the findings that co-treatment with CPX and PRE for 24 h increased the protein expression of DR4, DR5, Fas, and FADD (Figure 6A,B and Figure S4A,B), leading to activation of caspase 8, as detected by increased level of cleaved caspase 8 (Figure 5D,E and Figure S3).

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PMC11155445

It was also found that the complex (80a) adopted distorted octahedral geometry having one acyl thiourea ligand coordinated to the metal ion through S and O atoms, two chloride ions at the equatorial position, and two PPh3 at the axial position in solid state structure.

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PMC11087766

All cells imaged per each condition were quantified to avoid bias.

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PMC11701801

D, Weight of tumor xenografts derived from SS18–SSX fusion Fuji cell lines and harvested from mice treated once daily with 30 mg/kg CP-C27.

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PMC11767582

This reaction gave rise to the desired 1,5-disubstituted triazoles with complete regioselectivity in moderate to good yields (Table 2).

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PMC11657744

Scale bars, 200 nm Immunofluorescent staining of NIH3T3 cells incubated in serum-free media with an acetylated tubulin antibody further confirmed the differential effect of DA proteins on ciliary assembly (Fig. 2B).

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PMC7090062

Thus, further investigations into the possible mechanisms responsible for IM resistance in GISTs and the identification of novel therapeutic targets to overcome this chemotherapy resistance are urgently required.

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PMC7642379

Hierarchical clustering of the cell lines based on SNVs gave a slightly different trend compared to the transcriptomic comparison.

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PMC4816271

Whilst this toxicity could be considered relatively mild, more severe and even fatal incidences have been subsequently documented.

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PMC11770130

In addition, the serum C20–C24 ceramide levels were positively correlated to body weight, fat mass, body mass index, blood glucose level, serum triglyceride level, serum total cholesterol level, and serum low-density lipoprotein cholesterol for the adults (Supplementary information, Fig. S10), though the correlations b...

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PMC11487720

Cold shock alone did not affect the expression of WWOX, TRAF2 and α-tubulin (Fig. 6A).

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PMC9429973

Methods: This was a retrospective, observational cohort study.

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PMC10170482

Also, the pathological development of many diseases is associated with changes of values in stiffness, viscosity, curvature, and ECM architecture.

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PMC11575040

To conduct a clonogenic assay, 1 × 10 live cells were deposited onto a six-well plate and transfected with LINC00094 siRNA (LINC00094-2 or si-LINC00094-3), miR-1270 mimics, or scramble control.

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PMC11680578

< 0.001 as compared to that of the control.

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PMC11345828

Briefly, a previously reported construct was subcloned into an expression vector (pDEST-HisMBP) expressed in Escherichia coli BL21 CodonPlus (DE3) RIL (Stratagene) and purified through nickel-column and size-exclusion chromatography sequentially.

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PMC11240448

Hence, to devise synergistic drug combinations for these five basal BC cell lines, additional perturbations targeting various components of the RAS-RAF-MEK-ERK signaling cascade are necessary, which are absent in the existing dataset.

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PMC7153288

Genome sequence comparison was performed by BBMap's MinHash Sketch program.

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PMC11290772

The NK cells were then stimulated to mature using interleukin-2 (IL-2) and subsequently harvested.

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PMC11098378

Ceg10 was concentrated to 2.5 ml using a 10,000 MWCO Amicon 50 spin concentrator, subjected to centrifugation at 40,000 rpm (TLA55 rotor), and further purified using a Superdex highload 200 16/600 gel filtration chromatography column (Cytiva Life Sciences).

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PMC9429973

Summary/Conclusion: During the treatment with imatinib 400mg in I TL, 2/3 of patients achieved and maintained CCyR. Patients with achieved CCyR had significantly longer survival and 54% of patients achieved at least deep molecular response (MR4.0).

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PMC6600592

Other peptides specifically bound to the HLA-A2 residue activate CTL responds to prevent infection and eliminate HBV .

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PMC9424261

Representative images of IB are shown in the figure.

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PMC11742290

High LGR5 protein expression has also been associated with poor outcome and recurrence in cancers of the brain , lung , esophagus , breast , colon [11, 52–54], cervix and ovary .

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