OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11594806	This makes A3AR agonists promising candidates for anticancer therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "makes", "A3AR", "agonists", "promising", "candidates", "for", "anticancer", "therapies", "." ] ...
PMC3765139	In order to increase the signal strength, the antibody amplification protocol (FS450_0002) was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "order", "to", "increase", "the", "sig...
PMC11672881	To survive, cancer cells rely on the increased expression of antioxidant enzymes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "survive", ",", "cancer", "cells", "rely", "on", "the", "increas...
PMC11612626	Cell lines were authenticated and tested for mycoplasma contamination by ATCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "were", "authenticated", "and", "tested", "for", "mycoplasma", "contaminati...
PMC9429973	Key secondary endpoints include overall response rate (ORR, by Lugano and ISCL criteria for PTCL and CTCL, respectively), disease control rate (DCR; ≥stable disease [SD]), duration of response and OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	Additionally, we calculated the average rate of CN alterations in each cell line (Methods) (Fig. 7B), and the three groups of cell lines had similar rates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	In the several studies that have come out assessing WT-Grft’s potential use as an anti-SARS-CoV-2 prophylactic, Griffithsin tends to show a half-maximal inhibitory concentration against nCov-19 spike pseudotyped lentivirus in the ~300 nM to ~2000 nM range, which is about an order of magnitude less potent than Griffiths...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422150	The procedure has been described previously (Kuramoto et al., 2022b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "procedure", "has", "been", "described", "previously", "(", "Kuramoto...
PMC11615101	It was found that PKM and LDHA levels were upregulated in the recombinant α-Taxilin treated group (Figure 4D and E), and may be one of the factors responsible for the active metabolic shift, which is one of the crucial changes that take place in RAFLS during RA inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	NF-κB activity functions as a tumor suppressor in BL tumors, and high level Myc expression in B cells inhibits both the canonical and non-canonical forms of NF-κB signaling .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673128	In fact, recent discoveries pointed out the immunological properties of therapeutic strategies against ALK, such as ALK peptide vaccination in NSCLC and chimeric antigen receptor (CAR)-T cell therapy against ALK in neuroblastoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8740518	In colorectal cancer, total lipid content is reduced (Mika et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "colorectal", "cancer", ",", "total", "lipid", ...
PMC11742047	For MVA, the PCA plot and supervised multivariate models, such as supervised orthogonal projection to latent structures discriminant analysis (OPLS-DA), were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Here we present a case report of AML with persistent absent CD33 expression since diagnosis that we found to be mimicking MRD positivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ...
PMC11583010	These results suggested that ETx-22 would gain in vivo stability with possible translation to improved antitumor activity and higher tolerability than currently available ADCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11092418	Notably, we found a statistically significant association between the expression CD44 and response of HBCCLs to the treatment with dasatinib when such cancer cells were grown at higher rate (Table 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Arrow thickness corresponds to the enrichment score of each transcription factor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Arrow", "thickness", "corresponds", "to", "the", "enrichment", "score", "of", "each", ...
PMC11585994	The G5-sgc8-siBCL11B nanoparticles reduced the required siBCL11B dosage,26,57 thereby enhancing the overall safety profile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "G5-sgc8-siBCL11B", "nanoparticles", "reduced", "the", "required", ...
PMC11509278	The proportions of the level 1 classification of differentially abundant metabolites in negative ion mode were as follows: metabolism, 63.23%; organismal systems, 14.19%; human diseases, 9.68%; environmental information processing, 7.10%; cellular processes, 3.87%; and genetic information processing, 1.94% (Figure 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10955424	The fluids were divided into 2 groups (1: As001-As003, Cr001 and 2: As004-As013, Cr004) and tested separately.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9966931	Although most of these hybrids were previously synthetized chemically, we have reported their obtention by means of enzymatic catalysis for the first time in absence of solvents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	Antitumor immune response was activated following MSCs-p14 therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antitumor", "immune", "response", "was", "activated", "following", "MSCs-p14", "therapy", "." ] } ]
PMC11585587	However, most of the previous studies have focused on RA against solid tumors, and there are few studies on non-solid tumors such as MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9918897	According to the report, the histological examination revealed a section of a solid epithelial tumor with extensive necrosis infiltrating the surrounding tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accordi...
PMC8777939	Representative images and quantification of the fluorescent signal showed the significant inhibition of tumor growth by etravirine and the combined treatment of etravirine and paclitaxel (Figure 6a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Lille, Inserm, U1286 - Infinite, Lille Cedex; Centre Hospitalier Gustave Dron, Tourcoing; Univ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lille", ",", "Inserm", ",", ...
PMC11629143	The epigenetic state of promoters is especially significant in determining transcription potential .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "epigenetic", "state", "of", "promoters", "is", "especially", "significant", ...
PMC9429973	The mean age of SCD was lower (22y) than of THAL (39.4y).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mean", "age", "of", "SCD", "was", "lower"...
PMC11806106	The agonist-induced activation was normalized to the maximal activation and plotted as concentration-response curve (B) (mean ± SEM, n = 3 of independent measurements performed in triplets).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973725	Collectively, these results indicate that, like in other cancers, the low expression of ZNF677 in ccRCC may be due to its hypermethylation and can be considered as an adverse prognostic factor in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730320	The PCR product was visualized on a 2% agarose gel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PCR", "product", "was", "visualized", "on", "a", "2", "%", "agarose", "g...
PMC9960565	The solution was then purified with dialysis (MW 100–500 Da) for 4.5 h in distilled water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "solution", "was", "then", "puri...
PMC11407042	Passage A549 cells.a.	[ { "tags": [ "O", "B-CellLine", "O", "O" ], "tokens": [ "Passage", "A549", "cells.a", "." ] } ]
PMC10631132	The highest level of mineral resorption was observed in osteoclasts differentiated from the fibroblast-derived iPSC line using the EB protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "highest", "level", ...
PMC9878278	Similarly, BMP6 and Activin A were shown to suppress the growth of HBV in cell culture (Eddowes et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Pts in Cohort A who do not achieve a CR or PR will discontinue treatment on study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "in", "Cohort", "A", "who", "do", ...
PMC11345828	The title compound (40 mg, 58% yield) was prepared following General Procedure F using compound 60 (65 mg, 0.081 mmol, 1.0 equiv) and (S)-(tetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate (63 mg, 0.24 mmol, 3.0 equiv) followed by saponification using General Procedure G. LCMS Method 1: RT = 2.295 min, MS (ESI): mas...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	The introduction of autologous stem cell transplantation, bortezomib, and immunomodulatory drugs have changed myeloma management and improved the 5-year survival to approximately 60% (3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10048572	Loss Y and LOH D12S391 identified in Jurkat-O1 also appear in Jurkat-B4 subclones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Loss", "Y", "and", "LOH", "D12S391", "identified", "in", ...
PMC11632064	While inhibition of ULK1/2 with MRT68921 had similar pro-inflammatory effects in both cell lines, all other inhibitors had distinct effects (Fig 4A), as observed for BI-D1870 and BRD7389 (Fig 1D and G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10538569	To test trans-infection of transduced human primary CD4 T cells by DC-captured HIV-1, iDCs or mDCs were incubated with HIV-1 AD8 and Bru3 at MOI 5 for 2 hours in triplicate cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10605143	In the case of non-Gaussian distribution, the Kruskal–Wallis ANOVA was applied to verify the hypothesis on the equality of the medians with the Conover–Iman test or the Dunn test for pairwise comparisons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: AML patients aged≥18 years with refractory to ≥ 2 cycles of standard induction chemotherapy, or relapsed after achieved remission from prior treatments were enrolled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11011020	As anticipated, for all the cell lines and WGA samples, a substantial current density response was observed indicating the presence of different statuses of methylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	BTN3A targeting agonist antibody ICT01 is being developed in a multicentric Phase 1 and 2 study called EVICTION by Imcheck Therapeutics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BTN3A", "targeting", ...
PMC11626627	The expression was normalized to GAPDH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "was", "normalized", "to", "GAPDH", "." ] } ]
PMC9164404	Compared with CisPt(IV), Abplatin had better water solubility, which was conducive to the biological application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "with", "CisPt(IV", ")", ",...
PMC11543853	The position of the opening in the endosome membrane is indicated by a blue arrowhead.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "position", "of", "the", "opening", "in", "the", ...
PMC10565698	We confirmed that circUSP10 affected TCF12 by adsorbing miR-211-5p, ultimately influencing LC progression via the EMT pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "confirmed", "that", ...
PMC11247842	These genes were enriched in pathways for blood coagulation and plasminogen activating cascade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "genes", "were", "enriched", "in", "pathways", "for", "blood", ...
PMC10726501	Invasionassay was applied to detect the invasive capacities of GIST882 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Invasionassay", "was", "applied", "to", "detect", "the", "invasive", "capacit...
PMC11742231	By selecting the appropriate fusion operation, the method can improve the accuracy and robustness of our models, which can ultimately lead to better personalised treatments for patients as shown in Figs. 3, 4.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Two patients died >30 days after the last dose of navitoclax.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "patients", "died", ">", "30", "days", "after", "the", "last", "dose...
PMC11700340	This finding demonstrated the similarities in linagliptin and geldanamycin’s capacities to interact with HSP 90 (Figure 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "finding", "demonstra...
PMC11451829	The model can be used to replicate the inflammatory and vascular components of pterygium, which in turn enables the evaluation of drug preventive, therapeutic, and surgical approaches at different stages of pterygium-like lesion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10758402	GraphPad Prism were used in all graphs and statistical tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GraphPad", "Prism", "were", "used", "in", "all", "graphs", "and", "statistical", "tests", ...
PMC11395280	The use of these intrathecal drugs often has long-term toxic effects, and therefore, a better understanding of the molecular mechanisms that promote the invasion of T-ALL into the CNS could provide platforms for the development of targeted pharmaceuticals to prevent CNS entry and spare children from toxic therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753435	To construct the dataset for training this model, we first considered every interaction structure in the Protein Data Bank (PDB) (27) and specifically filtered to create appropriate training and testing datasets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9848491	Low risk and high-risk group of risk score is shown in Figure 3G .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Low", "risk", "and", "high-risk", "group", "of", "risk", "score"...
PMC11700340	Hsp90 disrupts the folding of mitochondrial proteins during cell mitosis; this mechanism Approved by our cytotoxicity study results that conduction to, the pattern of linagliptin cytotoxicity was manlily cell-cycle specific.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11714165	We then investigated the bone‐targeting capability of cyanine 5.5 (Cy5.5)‐labeled DN‐F (DN‐F) nanoparticles in vitro and in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "investigated",...
PMC11306331	We then imaged single cells to measure their initial FusionRed and iRFP expression as well as the extent of FUS condensation before and after blue light illumination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9920575	In this procedure, the whole fruit was used, which also included parts of the exocarp and the seed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "procedure", ...
PMC11045125	The supernatant containing the released cells was transferred to a fresh tube, centrifuged at 400g for 4 minutes at room temperature, the supernatant was removed, and the cells were resuspended in fresh A-RPMI media.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350	Expression of these cytotoxic molecules are shown for CAR positive (hCD34 +) or negative (hCD34-) CD8 TILs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", ...
PMC10530622	Studies have investigated the impact of hormones, non-alcoholic fatty liver disease (NAFLD) and Crohn’s disease on oxalate synthesis and excretion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11794588	The plant has been used in some cases as a febrifuge to help reduce fever, although it has to be used with caution as certain parts of the plant can be poisonous when consumed in the wrong way.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525293	The increased p63 occupancy was accompanied by an increase in histone H4 acetylation (Fig. 3D) and, consistently, in ACE2 protein levels (Fig. 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10222971	Accutase was added to each well, enough to cover the surface (300 µL) and incubated for 1–2 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10454535	Fetal bovine serum (FBS), penicillin-streptomycin solution, and PrestoBlue Cell Viability Reagent were purchased from Thermo Fisher Scientific (Grand Island, NY, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Sequenced clones containing single G-to-A changes were not considered hypermutated, as single mutations may have resulted from errors during PCR or sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequenc...
PMC11574271	This outcome implies that the reduction of has-miR-659-3p could potentially contribute to the elevated expression of RON in bladder cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "outc...
PMC10213179	The equilibrium binding constant was then calculated as the aptamer concentration needed to achieve a half-maximum binding at equilibrium [Y = Bmax × X/(Kd + X)].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A multicenter randomized-control trial phase 3 trial comparing Orca-T to SOC has been initiated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "multicenter", "randomized-control", "trial", "phase", "3", "trial...
PMC6617630	4MYC and BCL-6 transcription is regulated by BET bromodomain protein in DHL/THL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4MYC", "and", "BCL-6", "transcription", "is", "regulated", "by", "BET", ...
PMC9429973	Vγ9Vδ2 T cells relative frequencies were considered low for values below this threshold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vγ9Vδ2", "T", "cells", "relative", "frequencies", "were", "considered", "lo...
PMC11799620	This experiment used the response surface methodology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "experiment", "used", "the", "response", "surface", "methodology", "." ] } ]
PMC11760643	Fura‐2 AM fluorescence was measured at 510 nm every 5 s using a FlexStation 3 (Molecular Devices) following excitation at 340 and 380 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9596868	No. sc-358914) and anti-rabbit IgG-HRP (Cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "sc-358914", ")", "and", "anti-rabbit", "IgG-HRP", "(", "Cat", "." ] } ]
PMC9164404	B In vivo biodistribution of Abplatin labeled with Cy7.5 via in vivo imaging and ex vivo imaging of major organs at 36 h. C The corresponding semi-quantification of the fluorescence signal of Abplatin over time and biodistribution of major organs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8336407	In present study, the effects of the leaf extract of Pyrus biossieriana Buhse on tert-Butyl hydroperoxide (t-BHP) induced toxicity in the HepG2 cell line were investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC10938336	To explore the mode of action of the compounds against cancer, active ingredients–target protein and target protein–disease networks were constructed using Cytoscape version 3.8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Moreover, FB23-2 combined with ibrutinib diminished leukemia burden and splenomegaly in CLL mice (Figure 1H-I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "FB23", ...
PMC9693627	The insertion of PTCD2-c-myc was confirmed by PCR followed by detection of c-myc tagged protein after doxycycline induction by Western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "insertion", ...
PMC11538390	Variants with an imputation INFO score <0.8 and minor allele frequency (MAF) < 0.0001 were excluded, resulting in a combination of 15.36 M directly genotyped and imputed variants included in association tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742670	Following a 20-minute incubation in the dark at 37ºC, the cells are analyzed for DNA content using flow cytometry (ACEA Novocyte flow cytometer, ACEA Biosciences Inc., San Diego, CA, USA) with the FL2 signal detector (λex/em 535/617 nm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Using LASSO regression analysis, eight potential features were selected from the 54 candidate variables.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "LASSO", "regression", "analysis", ",", "eight", "p...
PMC11726183	In the current work, we used various aromatic rings such as phenyl, benzyl, naphthyl, and pyridyl, etc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", ...
PMC11774112	Poly(L-arginine) and poly(L-histidine) are efficiently taken up by cells and perform efficient gene condensation, which facilitate the release of encapsulated miRNA 34a into the cytoplasm.31 Due to its lipophilic properties, PLA can effectively encapsulate DTIC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6364197	The concentration of DDR1-IN-1 used was determined in Jurkat cells cultured in TCPS (Fig. 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "concentration", "of", "DDR1-IN-1", ...
PMC11740508	While highly effective in HRR mutated breast, ovarian, prostate, and pancreatic cancer, the benefits often remain short-lived.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "highly", ...
PMC8658661	However, the use of HepG2 cells as an HCC model is incorrect, and as shown in the study by Choi et al. (2015), there is no expression of the marker of HCC—hGSTP1 .	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11495567	(1:1000), RAF1 (CRAF) (Cat. #	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "(", "1:1000", ")", ",", "RAF1", "(", "CRAF", ")", "(", "Cat", ".", "#" ...
PMC9429973	Overall survival: Malignancy-associated HLH patients had poorer survival compared to non-malignancy-associated HLH (median OS 1.5 months vs not reached, p value 0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7917457	These results are in line with our previous studies reporting similar oncolytic potency of PeptiCRAd Ad5-D24-OVA as compared to uncoated Ad5-D24 in a human colorectal adenocarcinoma cell line and in two melanoma cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11539788	The effects of RNF19A on cell proliferation, migration, and invasion were explored by performing a series of in vitro experiments, including CCK-8, colony formation, wound healing, and Transwell invasion assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10965315	A2780 cells were cultured overnight in a medium without fetal bovine serum (FBS), then harvested and suspended in the same FBS‐free medium.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11734514	This was in line with previous research on the anticancer activity of a dipeptide Cyclo(-Pro-Tyr) from marine sponge C. fistularis in the liver cancer HepG2 cells lines, which inhibited Akt phosphorylation and increased PTEN.12 The inhibition of Akt/mTOR signaling pathway induced apoptotic cells death in various cancer...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11727000	Finally, a four-protein network centered on the protein CD2BP2 was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "a", "four-protein", "network", "centered", "on", "the", "protein...
PMC6163708	All cell lines were of human origin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "lines", "were", "of", "human", "origin", "." ] } ]

PMC11594806

This makes A3AR agonists promising candidates for anticancer therapies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "makes", "A3AR", "agonists", "promising", "candidates", "for", "anticancer", "therapies", "." ] ...

PMC3765139

In order to increase the signal strength, the antibody amplification protocol (FS450_0002) was used.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "order", "to", "increase", "the", "sig...

PMC11672881

To survive, cancer cells rely on the increased expression of antioxidant enzymes .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "survive", ",", "cancer", "cells", "rely", "on", "the", "increas...

PMC11612626

Cell lines were authenticated and tested for mycoplasma contamination by ATCC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "were", "authenticated", "and", "tested", "for", "mycoplasma", "contaminati...

PMC9429973

Key secondary endpoints include overall response rate (ORR, by Lugano and ISCL criteria for PTCL and CTCL, respectively), disease control rate (DCR; ≥stable disease [SD]), duration of response and OS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11216402

Additionally, we calculated the average rate of CN alterations in each cell line (Methods) (Fig. 7B), and the three groups of cell lines had similar rates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10747160

In the several studies that have come out assessing WT-Grft’s potential use as an anti-SARS-CoV-2 prophylactic, Griffithsin tends to show a half-maximal inhibitory concentration against nCov-19 spike pseudotyped lentivirus in the ~300 nM to ~2000 nM range, which is about an order of magnitude less potent than Griffiths...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11422150

The procedure has been described previously (Kuramoto et al., 2022b).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "procedure", "has", "been", "described", "previously", "(", "Kuramoto...

PMC11615101

It was found that PKM and LDHA levels were upregulated in the recombinant α-Taxilin treated group (Figure 4D and E), and may be one of the factors responsible for the active metabolic shift, which is one of the crucial changes that take place in RAFLS during RA inflammation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11045125

NF-κB activity functions as a tumor suppressor in BL tumors, and high level Myc expression in B cells inhibits both the canonical and non-canonical forms of NF-κB signaling .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11673128

In fact, recent discoveries pointed out the immunological properties of therapeutic strategies against ALK, such as ALK peptide vaccination in NSCLC and chimeric antigen receptor (CAR)-T cell therapy against ALK in neuroblastoma .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8740518

In colorectal cancer, total lipid content is reduced (Mika et al., 2020).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "colorectal", "cancer", ",", "total", "lipid", ...

PMC11742047

For MVA, the PCA plot and supervised multivariate models, such as supervised orthogonal projection to latent structures discriminant analysis (OPLS-DA), were performed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Here we present a case report of AML with persistent absent CD33 expression since diagnosis that we found to be mimicking MRD positivity.

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PMC11583010

These results suggested that ETx-22 would gain in vivo stability with possible translation to improved antitumor activity and higher tolerability than currently available ADCs.

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PMC11092418

Notably, we found a statistically significant association between the expression CD44 and response of HBCCLs to the treatment with dasatinib when such cancer cells were grown at higher rate (Table 5).

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PMC11224020

Arrow thickness corresponds to the enrichment score of each transcription factor.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Arrow", "thickness", "corresponds", "to", "the", "enrichment", "score", "of", "each", ...

PMC11585994

The G5-sgc8-siBCL11B nanoparticles reduced the required siBCL11B dosage,26,57 thereby enhancing the overall safety profile.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "G5-sgc8-siBCL11B", "nanoparticles", "reduced", "the", "required", ...

PMC11509278

The proportions of the level 1 classification of differentially abundant metabolites in negative ion mode were as follows: metabolism, 63.23%; organismal systems, 14.19%; human diseases, 9.68%; environmental information processing, 7.10%; cellular processes, 3.87%; and genetic information processing, 1.94% (Figure 4B).

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PMC10955424

The fluids were divided into 2 groups (1: As001-As003, Cr001 and 2: As004-As013, Cr004) and tested separately.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC9966931

Although most of these hybrids were previously synthetized chemically, we have reported their obtention by means of enzymatic catalysis for the first time in absence of solvents.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11770199

Antitumor immune response was activated following MSCs-p14 therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antitumor", "immune", "response", "was", "activated", "following", "MSCs-p14", "therapy", "." ] } ]

PMC11585587

However, most of the previous studies have focused on RA against solid tumors, and there are few studies on non-solid tumors such as MM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9918897

According to the report, the histological examination revealed a section of a solid epithelial tumor with extensive necrosis infiltrating the surrounding tissue.

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PMC8777939

Representative images and quantification of the fluorescent signal showed the significant inhibition of tumor growth by etravirine and the combined treatment of etravirine and paclitaxel (Figure 6a).

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PMC9429973

Lille, Inserm, U1286 - Infinite, Lille Cedex; Centre Hospitalier Gustave Dron, Tourcoing; Univ.

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PMC11629143

The epigenetic state of promoters is especially significant in determining transcription potential .

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PMC9429973

The mean age of SCD was lower (22y) than of THAL (39.4y).

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PMC11806106

The agonist-induced activation was normalized to the maximal activation and plotted as concentration-response curve (B) (mean ± SEM, n = 3 of independent measurements performed in triplets).

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PMC8973725

Collectively, these results indicate that, like in other cancers, the low expression of ZNF677 in ccRCC may be due to its hypermethylation and can be considered as an adverse prognostic factor in ccRCC.

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PMC11730320

The PCR product was visualized on a 2% agarose gel.

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PMC9960565

The solution was then purified with dialysis (MW 100–500 Da) for 4.5 h in distilled water.

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PMC11407042

Passage A549 cells.a.

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PMC10631132

The highest level of mineral resorption was observed in osteoclasts differentiated from the fibroblast-derived iPSC line using the EB protocol.

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PMC9878278

Similarly, BMP6 and Activin A were shown to suppress the growth of HBV in cell culture (Eddowes et al., 2019).

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PMC9429973

Pts in Cohort A who do not achieve a CR or PR will discontinue treatment on study.

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PMC11345828

The title compound (40 mg, 58% yield) was prepared following General Procedure F using compound 60 (65 mg, 0.081 mmol, 1.0 equiv) and (S)-(tetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate (63 mg, 0.24 mmol, 3.0 equiv) followed by saponification using General Procedure G. LCMS Method 1: RT = 2.295 min, MS (ESI): mas...

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PMC11188874

The introduction of autologous stem cell transplantation, bortezomib, and immunomodulatory drugs have changed myeloma management and improved the 5-year survival to approximately 60% (3).

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PMC10048572

Loss Y and LOH D12S391 identified in Jurkat-O1 also appear in Jurkat-B4 subclones.

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PMC11632064

While inhibition of ULK1/2 with MRT68921 had similar pro-inflammatory effects in both cell lines, all other inhibitors had distinct effects (Fig 4A), as observed for BI-D1870 and BRD7389 (Fig 1D and G).

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PMC10538569

To test trans-infection of transduced human primary CD4 T cells by DC-captured HIV-1, iDCs or mDCs were incubated with HIV-1 AD8 and Bru3 at MOI 5 for 2 hours in triplicate cultures.

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PMC10605143

In the case of non-Gaussian distribution, the Kruskal–Wallis ANOVA was applied to verify the hypothesis on the equality of the medians with the Conover–Iman test or the Dunn test for pairwise comparisons.

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PMC9429973

Methods: AML patients aged≥18 years with refractory to ≥ 2 cycles of standard induction chemotherapy, or relapsed after achieved remission from prior treatments were enrolled.

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PMC11011020

As anticipated, for all the cell lines and WGA samples, a substantial current density response was observed indicating the presence of different statuses of methylation.

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PMC9429973

BTN3A targeting agonist antibody ICT01 is being developed in a multicentric Phase 1 and 2 study called EVICTION by Imcheck Therapeutics.

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PMC11626627

The expression was normalized to GAPDH.

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PMC9164404

Compared with CisPt(IV), Abplatin had better water solubility, which was conducive to the biological application.

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PMC11543853

The position of the opening in the endosome membrane is indicated by a blue arrowhead.

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PMC10565698

We confirmed that circUSP10 affected TCF12 by adsorbing miR-211-5p, ultimately influencing LC progression via the EMT pathway.

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PMC11247842

These genes were enriched in pathways for blood coagulation and plasminogen activating cascade.

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PMC10726501

Invasionassay was applied to detect the invasive capacities of GIST882 cells. (

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PMC11742231

By selecting the appropriate fusion operation, the method can improve the accuracy and robustness of our models, which can ultimately lead to better personalised treatments for patients as shown in Figs. 3, 4.Fig.

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PMC9429973

Two patients died >30 days after the last dose of navitoclax.

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PMC11700340

This finding demonstrated the similarities in linagliptin and geldanamycin’s capacities to interact with HSP 90 (Figure 7).

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PMC11451829

The model can be used to replicate the inflammatory and vascular components of pterygium, which in turn enables the evaluation of drug preventive, therapeutic, and surgical approaches at different stages of pterygium-like lesion.

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PMC10758402

GraphPad Prism were used in all graphs and statistical tests.

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PMC11395280

The use of these intrathecal drugs often has long-term toxic effects, and therefore, a better understanding of the molecular mechanisms that promote the invasion of T-ALL into the CNS could provide platforms for the development of targeted pharmaceuticals to prevent CNS entry and spare children from toxic therapies.

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PMC11753435

To construct the dataset for training this model, we first considered every interaction structure in the Protein Data Bank (PDB) (27) and specifically filtered to create appropriate training and testing datasets.

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PMC9848491

Low risk and high-risk group of risk score is shown in Figure 3G .

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PMC11700340

Hsp90 disrupts the folding of mitochondrial proteins during cell mitosis; this mechanism Approved by our cytotoxicity study results that conduction to, the pattern of linagliptin cytotoxicity was manlily cell-cycle specific.

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PMC11714165

We then investigated the bone‐targeting capability of cyanine 5.5 (Cy5.5)‐labeled DN‐F (DN‐F) nanoparticles in vitro and in vivo.

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PMC11306331

We then imaged single cells to measure their initial FusionRed and iRFP expression as well as the extent of FUS condensation before and after blue light illumination.

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PMC9920575

In this procedure, the whole fruit was used, which also included parts of the exocarp and the seed.

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PMC11045125

The supernatant containing the released cells was transferred to a fresh tube, centrifuged at 400g for 4 minutes at room temperature, the supernatant was removed, and the cells were resuspended in fresh A-RPMI media.

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PMC11401350

Expression of these cytotoxic molecules are shown for CAR positive (hCD34 +) or negative (hCD34-) CD8 TILs.

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PMC10530622

Studies have investigated the impact of hormones, non-alcoholic fatty liver disease (NAFLD) and Crohn’s disease on oxalate synthesis and excretion.

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PMC11794588

The plant has been used in some cases as a febrifuge to help reduce fever, although it has to be used with caution as certain parts of the plant can be poisonous when consumed in the wrong way.

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PMC11525293

The increased p63 occupancy was accompanied by an increase in histone H4 acetylation (Fig. 3D) and, consistently, in ACE2 protein levels (Fig. 3C).

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PMC10222971

Accutase was added to each well, enough to cover the surface (300 µL) and incubated for 1–2 min at room temperature.

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PMC10454535

Fetal bovine serum (FBS), penicillin-streptomycin solution, and PrestoBlue Cell Viability Reagent were purchased from Thermo Fisher Scientific (Grand Island, NY, USA).

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PMC6889484

Sequenced clones containing single G-to-A changes were not considered hypermutated, as single mutations may have resulted from errors during PCR or sequencing.

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PMC11574271

This outcome implies that the reduction of has-miR-659-3p could potentially contribute to the elevated expression of RON in bladder cancer.

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PMC10213179

The equilibrium binding constant was then calculated as the aptamer concentration needed to achieve a half-maximum binding at equilibrium [Y = Bmax × X/(Kd + X)].

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PMC9429973

A multicenter randomized-control trial phase 3 trial comparing Orca-T to SOC has been initiated.

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PMC6617630

4MYC and BCL-6 transcription is regulated by BET bromodomain protein in DHL/THL cells.

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PMC9429973

Vγ9Vδ2 T cells relative frequencies were considered low for values below this threshold.

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PMC11799620

This experiment used the response surface methodology.

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PMC11760643

Fura‐2 AM fluorescence was measured at 510 nm every 5 s using a FlexStation 3 (Molecular Devices) following excitation at 340 and 380 nm.

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PMC9596868

No. sc-358914) and anti-rabbit IgG-HRP (Cat.

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PMC9164404

B In vivo biodistribution of Abplatin labeled with Cy7.5 via in vivo imaging and ex vivo imaging of major organs at 36 h. C The corresponding semi-quantification of the fluorescence signal of Abplatin over time and biodistribution of major organs.

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PMC8336407

In present study, the effects of the leaf extract of Pyrus biossieriana Buhse on tert-Butyl hydroperoxide (t-BHP) induced toxicity in the HepG2 cell line were investigated.

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PMC10938336

To explore the mode of action of the compounds against cancer, active ingredients–target protein and target protein–disease networks were constructed using Cytoscape version 3.8.

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PMC9429973

Moreover, FB23-2 combined with ibrutinib diminished leukemia burden and splenomegaly in CLL mice (Figure 1H-I).

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PMC9693627

The insertion of PTCD2-c-myc was confirmed by PCR followed by detection of c-myc tagged protein after doxycycline induction by Western blotting.

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PMC11538390

Variants with an imputation INFO score <0.8 and minor allele frequency (MAF) < 0.0001 were excluded, resulting in a combination of 15.36 M directly genotyped and imputed variants included in association tests.

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PMC11742670

Following a 20-minute incubation in the dark at 37ºC, the cells are analyzed for DNA content using flow cytometry (ACEA Novocyte flow cytometer, ACEA Biosciences Inc., San Diego, CA, USA) with the FL2 signal detector (λex/em 535/617 nm).

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PMC9429973

Using LASSO regression analysis, eight potential features were selected from the 54 candidate variables.

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PMC11726183

In the current work, we used various aromatic rings such as phenyl, benzyl, naphthyl, and pyridyl, etc.

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PMC11774112

Poly(L-arginine) and poly(L-histidine) are efficiently taken up by cells and perform efficient gene condensation, which facilitate the release of encapsulated miRNA 34a into the cytoplasm.31 Due to its lipophilic properties, PLA can effectively encapsulate DTIC.

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PMC6364197

The concentration of DDR1-IN-1 used was determined in Jurkat cells cultured in TCPS (Fig. 7A).

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PMC11740508

While highly effective in HRR mutated breast, ovarian, prostate, and pancreatic cancer, the benefits often remain short-lived.

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PMC8658661

However, the use of HepG2 cells as an HCC model is incorrect, and as shown in the study by Choi et al. (2015), there is no expression of the marker of HCC—hGSTP1 .

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PMC11495567

(1:1000), RAF1 (CRAF) (Cat. #

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PMC9429973

Overall survival: Malignancy-associated HLH patients had poorer survival compared to non-malignancy-associated HLH (median OS 1.5 months vs not reached, p value 0.01).

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PMC7917457

These results are in line with our previous studies reporting similar oncolytic potency of PeptiCRAd Ad5-D24-OVA as compared to uncoated Ad5-D24 in a human colorectal adenocarcinoma cell line and in two melanoma cell lines.

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PMC11539788

The effects of RNF19A on cell proliferation, migration, and invasion were explored by performing a series of in vitro experiments, including CCK-8, colony formation, wound healing, and Transwell invasion assays.

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PMC10965315

A2780 cells were cultured overnight in a medium without fetal bovine serum (FBS), then harvested and suspended in the same FBS‐free medium.

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PMC11734514

This was in line with previous research on the anticancer activity of a dipeptide Cyclo(-Pro-Tyr) from marine sponge C. fistularis in the liver cancer HepG2 cells lines, which inhibited Akt phosphorylation and increased PTEN.12 The inhibition of Akt/mTOR signaling pathway induced apoptotic cells death in various cancer...

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PMC11727000

Finally, a four-protein network centered on the protein CD2BP2 was observed.

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PMC6163708

All cell lines were of human origin.

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