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PMC11401350
In this CAR construct, we subsequently changed the EF1α promoter for the PGK promoter by PCR amplification of the PGK sequence using the restriction sites EcoRI and ClaI. The pHnse- Δ18mut-L3-MSE10 was a gift by C.J. Buchholz (Paul Ehrlich institute, Langen, Germany) and was generated by inserting via the SfiI/NotI res...
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PMC11754784
From left to right: control, Nb-S, DNP1, DNP3.
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PMC11409031
Explain the bubble diagram correlating the module with T cell subpopulations.
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PMC8409415
NACT use has a potential to induce the expression of CD70, and CD70‐ADC may show an antitumor effect even in platinum‐resistant OvCA when the tumor showed CD70 expression.
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PMC9398137
Target cells were infected with an equivalent multiplicity of infection for 24 hours and the transductants were selected in the growth medium containing 2 to 3 μg/mL puromycin (LKO1-shRNAs) or 1 mg/mL G-418 (CDH-cDNAs).
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PMC11471176
C07.
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PMC9429973
H. Quach, X. Leleu, M.-V. Mateos, S. Z. Usmani, A. K. Nooka, A. Goldrick, R. Najdi, N. Shu, T. Facon University of Melbourne, St Vincent’s Hospital, Melbourne, VIC, Australia; CHU de Poitiers, La Miletrie/INSERM CIC 1402, Poitiers, France; University Hospital Salamanca/ISAL, Salamanca, Spain; Memorial Sloan Kettering C...
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PMC5443223
CEP164 is required for genomic stability and CEP164 expression is cell cycle stage-dependent, being expressed at the end of the S phase and the beginning of the G2/M phase (16).
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PMC9429973
Results: Here, we found that r/r MM is characterized by a state of activated SUMOylation, a ubiquitin-related post-translational protein modification pathway.
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PMC11680562
In addition, CuO NPs cause a considerable disruption of the mitochondrial membrane potential in cancer cells.
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PMC11047729
KRG has been found to induce apoptosis and down-regulate hTERT expression in a concentration-dependent manner .
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PMC9429973
The utility of Heparin-Induced Multiple aggregometry (HIMEA) in this setting has not been evaluated.
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PMC11566417
Finally, by modulating the immune response, the stem cell secretome may reduce host immune response-derived tissue damage and bacterial immune evasion [16, 24–29].
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PMC11435360
Bladder cancer (BC) is the 10th most common malignancy worldwide, with almost 600,000 new cases and over 200,000 associated deaths occurring in 2020 alone .
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PMC9429973
Secondary endpoints included HR rate at Wk 13 (and 1 yr; data not shown); time to HR and its duration; changes in transfusion need; safety outcomes; and the rate of clonal evolution.
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PMC11188874
Efficient and stable gene KO was verified by Western blot analysis.
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PMC11306331
We performed additional analyses to further characterize MBP-driven condensate dissolution.
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PMC7039683
Embryos injected with a reporter construct built from a 700 bp element centered on SNP2, harboring the risk or non-risk allele as indicated.
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PMC11706491
Next, we decided to test FLCCR in conditions in which either G1/S or G2 phases were extended.
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PMC11530949
For example, bimetallic Ag-doped CuO NPs are synthesized using Alternanthera sessilis (Linn).
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PMC11782780
Zhang et al. proposed that by modulating BCSC-associated genes, for instance, salinomycin can induce BCSC differentiation into normal cells, quiescent cells, and mature cancer cells.
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PMC11298021
Furthermore, this downregulation was more pronounced in cells treated with both miRNAs and rapamycin, compared to cells treated with either agent alone, indicating the additive effects of these compounds on the expression levels of PI3K/AKT/mTOR genes.
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PMC7171147
f Western blot of CPT1A in ES2 scrambled and shFASN cells cultured in either PBS or COL11A1-coated plates.
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PMC11733919
One can also suggest that MNP@CD26@17D-induced ferroptosis may be due to the potentiated inhibitory effect on HSP90 expression compared to the HSP90 inhibitory action of the free drug 17-DMAG (Figure 3f).
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PMC11596967
Ddes-P3 provided considerable defense against IR-induced oxidative stress in CHO-K1 cells, demonstrating a notable reduction in ROS production and lipid peroxidation.
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PMC11490153
A qPCR master mix was purchased from Amplicon (Denmark).
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PMC11549612
BOLA proteins interact with key EMT regulators, such as Snail, Twist, and Slug, to promote the acquisition of mesenchymal traits in cancer cells, facilitating their ability to migrate, invade surrounding tissues, and disseminate to distant organs.
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PMC9219615
In addition, cell seeding, controls, data acquisition, and data analysis were performed in a manner consistent with our other cytometric experiments.
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PMC11525028
or combination (paliperidone: 1 mg/kg daily, i.p.,
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PMC11686380
The father’s sample was not available due to divorce.
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PMC11758416
•Edit the gating strategy for individual experiments instead of using replicated gates.•Maintain consistency across experiments by including fluorescence minus one (for Annexin V and 7-AAD) and non-stimulated (no anti-CD3 incubation for L cells) controls within each batch.
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PMC9784246
The latter is up to now still the major approach used in clinics.
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PMC11791264
D and E, stability of endogenous LC3B protein was determined by Western blot in HEK293T cells stably expressing pCDH or pCDH-SETD7, followed by 36 μM cycloheximide (CHX) treatment for the indicated times.
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PMC9559528
A complete blood count (CBC) revealed mild microcytic anemia, and serum chemistry demonstrated mildly decreased high-density lipoprotein (HDL) (Table 1). (
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PMC11348300
In Figs. 1E, 5, and 6, the CBR is displayed as a function of time before and after palpation.
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PMC11486946
Single-molecule imaging began 1 minute after EGF addition.
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PMC11766350
In contrast, the scrambled shRNA control showed a significantly lower percentage of DR5 positive cells than the anti-gfp shRNA sample (84.8% vs. 92.4%, respectively, p < 0.01, t-test), likely due to the internalization of DR5 with TRAIL expression, as well as a significantly higher mean fluorescence (p < 0.05, t-test) ...
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PMC11767582
4-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzene-1,2-diol (3q): Starting from 2b (74 mg, 0.5 mmol) and following the general procedure described before, compound 3q was purified by chromatography, eluting with n-hexane-EtOAc (1:3).
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PMC11743975
An FV3000 confocal microscope (Olympus) with a 100 × NA 1.4 oil object was used for imaging.
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PMC11609529
In this study, we employed YM-positive ES-2 ovarian cancer cells as a model to explore the roles of the YM fusion in cancer initiation and maintenance.
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PMC8584666
The guide RNA sequence of CRISPR/Cas9 could bind to both the transfected GPI-80 cDNA and GPI-80 gene in the genome.
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PMC11680982
A,B) CCK-8 and colony formation assays were performed to detect the effects of various concentrations of CDK4/6 inhibitor (palbociclib) combined with endocrine therapy (100 nM, fulvestrant) on the proliferation of HR/HER2-low breast cancer cells.
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PMC11672142
The UV–vis spectrum for the Fe(triapine)2 species (11) shows two LMCT absorbances at 455 nm (ε = 12,800 M cm based on compound concentration) and 500 nm (ε = 3200 M cm based on compound concentration).
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PMC9429973
Methods: The study involved SMF patients of the MYSEC (Myelofibrosis Secondary to PV and ET) project.
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PMC11666785
This is followed by determining the position (centroid) and the number of photons.
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PMC9429973
However, we found a significant correlation of sensitivity to the dual inhibitor (AZD4320) with BCL-2 inhibition (venetoclax; N=13; rs=0.56; p=0.049), but no association with BCL-XL inhibition (A-1331852).
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PMC11515150
Hence, it highlights the need for innovative therapeutics.
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PMC9509578
Gold (Au) and iron oxide nanoparticles (Fe3O4 NPs) have intrinsic properties that make them ideal nanosystems to facilitate therapies using radiation, photodynamics and hyperthermia.
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PMC11228511
Scale bar, 2 µm.) (
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PMC9268620
The control (untreated) cells appeared to be large and healthy, and they came in irregular shapes and sizes.
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PMC11730311
In this present study, vascular measurements were performed in rat mesenteric arteries since they densely express the CGRP-R and are known to be responsive to αCGRP.
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PMC11310713
The pharmaceutical HRT groups, especially in the high-dose E2-treated group, exhibited a further increase in endometrial thickness, and even in the low-dose E2 group, a significant increase was observed compared to OVX rats.
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PMC11477621
All stained cells analyzed using BD FlowJo 10.8 software and Annexin V+/PI− is regarded as early apoptotic cells, while Annexin V+/PI+ (A211-02, Vazyme, Nanjing, China) is regarded as late apoptotic cells.
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PMC9454178
However, the role of CDK7 in the progression of GIST has not yet been elucidated.
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PMC10877303
These include suppressing adipogenesis through the repression of the Akt-FOXO1-PPARγ axis , significant cytotoxicity against nine tested cancer cell lines , notable antifeedant activity tested against Reticulitermes speratus , and cytotoxicity against human cancer cell lines .
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PMC11742047
Heatmaps depicting metabolic changes associated with CBD treatment observed in LC–MS (-).
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PMC11506670
We report the functional characterization of the novel NRAS mutants—G48C, Q43K, and E37K—identified in Filipino young-onset CRC patients.
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PMC10940855
One-hundred microliters of mouse peripheral blood was collected in 1.5 mL Eppendorf tubes.
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PMC9429973
Summary/Conclusion: Our data confirms the well-recognised efficacy of purine analogs in the treatment of HCL in a real-world population of patients, presenting very good response rates both in first and subsequent treatment lines.
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PMC10840195
The results show that SR-A498 cells have a higher proliferation ability than A498 cells.
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PMC9960565
Pt-NMR (86 MHz, D2O) [ppm]: δ= −2119.18 (PtO2).
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PMC9429973
The initial analysis of the bown marrow aspirate showed a myeloid hyperplasia at 82% with a blast rate of 1%.
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PMC10079526
These data demonstrate the in vivo potential for TAK981 to enhance hypomethylation drug 5-Aza-2’ efficacy.
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PMC7887261
g Overproduction endogenous DNA damage assay scheme.
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PMC11224020
Strikingly, we observed that the numbers of migratory cDC2s found in inguinal lymph nodes were significantly decreased in WASp and cPLA2 mice (Fig. 5a–d).
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PMC10761571
In contrast, the intrinsic pathway causes cytochrome-c release from the mitochondrial membrane and activating the initiator caspase-9.
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PMC11684821
Jurkat cells expressing the MC.27.759S TCR responded to multiple cancer cell lines that naturally expressed either MR1*01 or MR1*02 but did not respond toward healthy CD14 monocytes or CD19 B cells from 3 donors (Figure 2G).
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PMC11489175
A link between the DDR and EMT has been established, because cisplatin exposure of ovarian cancer cells results in USP1 phosphorylation by ATM and ATR, the two core kinases of the DDR; such a phosphorylation is required for binding to Snail, a process activating stemness feature that can ultimately induce cell reprogra...
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PMC9646302
The samples were subjected to 10% sodium dodecyl-sulfate polyacrylamide gel electrophoresis and subsequently transferred onto polyvinylidene difluoride membranes.
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PMC11757230
Although few studies in veterinary medicine have explored the effects of MSCs on malignant tumor cells, our group previously demonstrated that canine adipose-derived MSCs (cADSCs) promoted the proliferation and invasion of a canine hepatocellular carcinoma cell line in vitro .
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PMC11700340
In addition, Hsp90 plays a key role in conformational maturation and stability of client proteins in transducing proliferative and anti-apoptotic signals.
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PMC11568601
GO enrichment analysis of genes classified as profile 15 revealed that “IRE1-mediated UPR” was the most enriched biological process, and “Protein processing in ER” was identified as the most enriched KEGG pathway (Fig. 4C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9220170
However, no significant changes in mRNA expression of other studied genes were observed.
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PMC3765139
Magnetically sorted tumor cells were subcutaneously injected into the flanks of immunodeficient mice.
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PMC9429973
Imaging studies also revealed that perivascular stromal cells are morphologically damaged in allo-SCT mice.
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PMC10142392
Drug release was characterized by an initial rapid release, followed by sustained release over a period ranging from 10 to 68 hours .
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PMC11655536
In addition, TFE3 knockdown decreased HA-induced apoptosis (Fig. 4E, F).
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PMC11144200
Female NOD/SCID mice of SPF grade had been purchased from Zhuhai Baitry Tong Biomedical Technology Co., LTD. (
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PMC11703896
The cell lines L929, A549, Hela, MCF7, and MG63 were obtained from the National Centre for Cell Sciences (NCCS), Pune, India and cultured in Dulbecco’s modified Eagles medium, DMEM (Sigmaaldrich, USA).
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PMC11783017
2Preparation and characterization of Cis/Mn/NH@PGP. (
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PMC6461034
To explore the discriminative power of INKA scoring, we analyzed pTyr‐phosphoproteomic data from wild‐type versus mutant cells, and from untreated versus drug‐treated cells as genetic and pharmacological dichotomies (Fig 5, Dataset EV4).
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PMC11531735
Tumor volumes were assessed using Vernier calipers on alternate days, and the calculated volumes were graphically represented using GraphPad Prism software.18 The metastases studies were conducted in accordance with the approved Institute Animal Care and Use Committee (IACUC) protocol (AUP-0320-0023) at the Houston Met...
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PMC11705862
The same protocol as above was used with mouse-anti-AT8 (1:500, Invitrogen) and the IRIS-1 and 2 antibodies as the primary antibody.
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PMC11476837
We observed that each NRF2 inhibitor sensitized doxorubicin-resistant HL-60/DR cells to the drug.
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PMC9429973
Summary/Conclusion: In conclusion, we offer proof of concept that the targeted SHM which shapes the CLL BcR IG repertoire may produce idiotypic targets for T cell-based therapy or peptide vaccine design.
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PMC10812665
Indeed, many toxicants can lead to pronounced, rapid and specific metabolome changes that are not necessarily followed by corresponding transcriptome regulations (e.g., when the cell dies or when the energy status is too low, or when oxidative stress destroys key enzymes required).
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PMC10154881
However, there have been accumulating reports that some epithelial cancer cells such as breast, lung, pancreatic, colon, and ovarian cancer cells highly express NECTIN4. , , , , , , , , ,
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PMC11424574
The Cancer Genome Atlas (TCGA) and TARGET databases in TNMplot (accessible at https://tnmplot.com/analysis/; accessed June 1, 2023) provided us with MTA2 and uPA mRNA expression data and clinical data from 1109 normal samples and 4608 OS tumor samples.
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PMC11285179
This heterodimer binds to retinoic acid response elements (RAREs) in the promoter region of target genes , including ANGPT1.
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PMC9786247
Even 7 days after inoculation with C. burnetii, differences in the expression of pro-inflammatory cytokines compared with uninoculated PS cells were only barely detectable (Figure 3).
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PMC11746948
Data are presented as mean ± SD.
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PMC9429973
Fragment crystallizable receptor-like 5 (FcRH5) is expressed on myeloma cells with near 100% prevalence (Li et al. 2017), constituting a novel therapeutic target.
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PMC11785489
We used early stopping to mitigate overfitting, training only until classification performance stopped improving in the held-out testing data (Figures S5A–S5D).
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PMC11525293
ACE2 is a p63 transcriptional target.
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PMC10329237
However, treatments significantly reversed the effect of BLM on MDA levels in A549 cells (Figure 3A).
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PMC11473843
Immunoblot against FAK in HBEC3 parental, HBEC3 mixed population before GFP cell FACS sorting and HBEC3 FAK knockout clone. (
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PMC8609870
Recent studies have shown that AQP1 participated in the occurrence of diseases through the ceRNA network .
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PMC11723947
Since SUV39H1 KO cells phenocopy HP1γ-deficient cells in vivo, we finally tested whether similar results could be obtained by exposing wild-type cells to chaetocin, a SUV39H1 inhibitor.
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PMC11546117
The two most abundant product ions of each analyte were selected to be the quantifier and qualifier.
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PMC8956657
A list of hydrogen-bonded interactions is presented in Supplementary Table 14.
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