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OTAR3088
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PMC11322866
Absence of Lamin B1 in the nuclear envelope (1), diffused Lamin B1 around the nuclear envelope (2), and perinuclear Lamin B1 aggregates (3) were observed in senescent MM cells.
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PMC5833712
Clinical trials in the search for innovative, targeted therapies for treatment of ovarian cancer is ongoing but so far no standard second-line treatment stands out as superior with regard to efficacy or safety.
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PMC11634794
And the efficiency of cell infection was evaluated by fluorescence microscopy after 72 hours.
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PMC11787355
The surgery was conducted under anesthesia (Ketamin, 100 mg/kg i.p.
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PMC11612315
Detection of the interaction between exendin 9–39 and TRPV1 via western blotting with an anti-human TRPV1 antibody.
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PMC9429973
In the clinical practice, our findings suggest to include TFRC sequencing analysis for patients with unexplained anemia.
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PMC7090062
Subsequently, miR-30a was confirmed to be an IM sensitizer via a mechanism that was attributed to its involvement in the regulation of cell autophagy.
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PMC10748106
A harmonic frequency analysis was performed to ensure that the structure corresponds to a minimum on the potential energy surface.
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PMC10788478
Molecular abnormalities in the Wnt/β‐catenin pathway confer malignant phenotypes in lung cancer.
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PMC11470999
Additionally, PF can induce cancer cell death, potentially enhancing antitumor immune responses through increased antigen release.
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PMC9429973
However, since the use of pediatric-like protocols for Philadephia (Ph) negative ALL (GRAALL), and treatments based on tyrosine kinase inhibitor (TKI) for Ph + ALL (GRAAPH), great improvements in adult ALL therapy have resulted.
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PMC11484188
The cells were incubated at 37˚C in a culture chamber for 48 h, washed once with PBS at 4˚C and removed from the plate using a cell scraper.
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PMC10958426
The cell-cell communication of DEGCNV and DEGreg are mainly cell-cell contact and secreted signaling, respectively (Fig. 5C and D), which is consistent with our aforementioned enrichment analysis that DEGCNV and DEGreg enriches in cell adhesion and cytokine signaling genes, respectively.
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PMC11122631
The COSY cross-peaks of H-10/H-11, in combination with the HMBC correlations of H-8/C-9, H-10/C-8, C-9, C-12, H-11/C-12, and H-13/C-12, indicated the presence of a cyclopentenone moiety and its connection to α- and ω-side chains.
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PMC11638255
We therefore postulated that copper chelating agents such as TEPA can redirect the flow of copper ions from the “rich” tumor cells to the “poor” immune cells to slow tumor progression and reinvigorate anti-tumor immunity.
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PMC11228511
It is difficult to reproducibly achieve comparable expression levels with transiently transfected SMCs or “mixed stable” SMCs—or with studies with human fibroblast cell lines.
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PMC11344246
Recently, TRIP13 has been shown to interact with the Wnt pathway in colorectal cancer, where it is significantly more highly expressed in tumours than in adjacent normal tissue (52).
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PMC9693627
Total run time was 90 min, which included initial 4 min of column equilibration to buffer A (0.1% formic acid), then gradient from 5 to 35% of buffer B over 65 min, then 6 min to reach 99% of buffer B, flushing 10 min with 99% of buffer B and 5 min re-equilibration to buffer A. MS analysis was performed at least in tri...
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PMC7709199
The glycan stub sits at the center of this oligomer and makes contacts with the symmetry-related glycan stub from the other Ig9 molecule that is part of the interface (Figs. 1 ▸ b and 1 ▸ c).
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PMC9429973
We observed that the expression of the TCR variants TRAV20 and TRAV13-1 was increased in patients with AML compared to high risk MDS (Figure 1A).
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PMC11544122
NET BRET was calculated by subtracting the ratio of the background (average of 3–6 replicates).
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PMC11604830
The formulations displayed a mean size of 14.6 ± 0.4 nm (polydispersity index, PDI, of 0.29 ± 0.06), 119 ± 14 nm (PDI 0.09 ± 0.03), 135 ± 15 nm (PDI 0.12 ± 0.04), respectively.
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PMC9611901
This means that at the time when our experiments were conducted, we could not predict that the ban would come into force.
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PMC6461034
Add lysis buffer (9 M urea, 20 mM HEPES pH 8.0, 1 mM sodium orthovanadate, 2.5 mM sodium pyrophosphate, 1 mM β‐glycerophosphate) in a 1:40 wet weight‐to‐lysis buffer ratio.
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PMC11799620
The cells without cadmium were considered as control cultures.
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PMC11397654
All the six calixarene derivatives were moderately cytotoxic toward MCF-7 and MIA PaCa-2 cancer cell lines, with compound 29a exhibiting the best selectivity for malignant cells (epithelial cell line HEK293 was used as a reference).
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PMC11719944
Research aiming to find effective treatments for T1D has shown that PRL treatment can enhance the engraftment and function of transplanted pancreatic islets, and it may prevent diabetes in patients treated with streptozotocin .
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PMC10094992
The pellet (nuclei) was washed 5 times with Buffer B (50 mM HEPES, 0.4 M NaCl, 1 mM EDTA) and then resuspended in 3× pellet volume of Buffer B supplemented with protease inhibitors, sonicated, and then incubated on a thermomixer for 20 min at 4 °C with 1300 rpm.
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PMC11791264
This methylation destabilizes LC3B via ubiquitin-mediated protein degradation.
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PMC11365427
Subsequently, the cells were treated with phenylalanine deprivation for 48 h. Cells were washed with PBS, fixed in 4% paraformaldehyde for 20 min, and permeabilized with 0.2% Triton X-100 in PBS for 10 min.
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PMC9739791
In a further report by Alonso-de Castro et al., the antiproliferative activity of Rf-1 and Rf-4 mixtures was assessed on the PDT-resistant Capan-1 cell line (pancreatic cancer) .
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PMC11763533
The bioluminescent activity was monitored using the same equipment, at time intervals of 40 min between the images, for a period of 12 h. The graph of activity versus time was plotted as a function of the relative activity of the luciferases.
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PMC11001582
We now show TGF-β1 expression can lead to a neuroprotective increase in the neuronal expression of ECM proteins and specifically collagen VI.
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PMC11726848
Cytotoxic, cytostatic, and cytomodifying (such as giant cell formation or senescence) effects contribute to the results of the assays .
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PMC11621493
Assay was performed in the absence of 1 mM CaCl2, and lipids were analyzed by HPLC-MS.
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PMC9577200
Other studies showed that it was not toxic to the bacteria (Das et al., 2011; Ruiz et al., 2011).
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PMC11706491
Then, cells were quickly placed in the microscopy chamber at 30°C.
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PMC7039683
Plot of average density of H3K27Ac ChIP-seq signal (purple) and ATAC-seq signal (green). (
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PMC9429973
Studies of drug combination were also performed to inhibit different signaling pathways at the same time.
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PMC9884169
AdPlus-mCherry-GFP-LC3B reporter system was used to detect the effect of MCT4 on autophagy in 5637 cells, and the effect of knockdown of MCT4 on apoptosis was analyzed by flow cytometry.
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PMC11476666
A549 cells appeared to be resistant to stilbene treatments, with no significant reduction in cell viability observed for RSV concentration up to 100 μM, while DHS showed a reduction in viability starting at 15 µM, although the cytotoxicity threshold remained above 70% .
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PMC11593084
In reduced conditions, we confirm the purity of original and recombinant mAbs by SDS-PAGE (Supplementary Figure S1).
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PMC10329237
P<0.001 significant difference vs the control group; #P<0.05, ##P<0.01, and ###P<0.001 vs the BLM group; &P<0.05 and &&&P<0.001 vs the PFD group Scale bar: 100 µm; BLM: bleomycin; LOS: losartan; PFD: pirfenidone; LOS: losartan Effect of BLM, PFD, LOS, and combination of pirfenidone with losartan (PFD+LOS) on A549 oxida...
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PMC11788920
Targeting individual sites in the nontemplate strand (NTS) with CRISPR–dCas9 reduced both the c-Myc mRNA and protein levels (by 1.8- and 2.5-fold, respectively), while targeting two sites simultaneously further suppressed both the mRNA (by 3.6-fold) and protein (by 9.8-fold) levels.
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PMC10938336
When compared with other curcumin derivatives, these compounds possess greater affinity for binding to P-gp, in turn, inhibiting the growth of breast cancer stem cells.
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PMC8740518
Additionally, bioinformatics analysis was used to investigate differential genes between tumor and normal tissues, and survival-associated genes.
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PMC9786247
with some variation between strains.
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PMC9516447
GRP78 knockdown reduced KRAS protein level and increased phosphorylated eIF2α (Serine 51) level as expected, however treatment with GSK2606414, while successfully blocking GRP78 knockdown mediated increase in eIF2α phosphorylation, failed to restore KRAS protein level in the si78 treated cells (Fig. 2B).
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PMC11742864
In the clinic, the levels of CRP in the blood are usually used as an indicator for the detection of systemic inflammation.
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PMC11285179
Multiple comparisons were analyzed by one-way ANOVA using the LSD test.
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PMC11773391
There was a recent review that outlined how vitamin D signalling, defined by selective activation of specific nuclear receptors and specific vitamin D hydroxyl derivatives, can provide benefits for new or existing treatments , which opens a window of opportunity to augment existing treatments with simple nutritional pr...
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PMC7823217
Bioprinting technology can create graded macroscale architectures mimicking the ECM, thereby enhancing the attachment and proliferation of different cell types, simultaneously.
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PMC11317131
Cells were sorted three days post transfection for DsRed expression to exclude non-transfected cells before analysis by ddPCR.
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PMC11767793
The IC50 values were calculated from the dose–response data by fitting them to a sigmoidal function using Sigmaplot 12.0.
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PMC11267830
e Western blot analysis was performed to validate the protein expression changes occurring in the J.gamma1 and Jurkat cell lines after treatment with indisulam for 24 and 48 h, respectively Indisulam is highly efficacious in in vitro models of T-ALL.
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PMC11089031
T cells, B cells, proximal tubular cells, and collecting tubule cells are the dominant cell types in normal kidney tissue where ZNF692 is expressed.
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PMC11786767
In this report, we provide new evidence that biotin-DHPE specifically labels the lipid signals in COS-7 cells.
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PMC11726848
Thus, we can talk about the potential danger of HDR irradiation over LDR irradiation due to the formation of “giant cells”.
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PMC9429973
F. Pane, F. Castagnetti, L. Luciano, A. Russo Rossi, E. Abruzzese, R. Bassan, G. Binotto, G. Caocci, G. Cimino, P. Fazi, A. Gozzini, M. Lunghi, R. Marasca, B. Martino, M. Bonifacio, F. Cavazzini, F. Paoloni, G. Saglio, S. Sica, A. Tafuri, D. Vallisa, M. Vignetti, P. Westerweel, G. Rosti, M. Breccia Dpt.
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PMC9429973
This result is in agreement with the observed by optic microscopy.
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PMC11721587
After 48 hours, viruses containing culture media were collected, filtered, and centrifuged at 20,000g for 2 hours, and the resulting precipitates were resuspended in culture medium and stored in aliquots at −80°C for future use.
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PMC11713609
To corroborate these findings, we knocked out PHLDA2 in human breast cancer MCF7 cells (Figure 1D).
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PMC11277157
The ATF3 is a regulator that links inflammation, oxidative stress, and immune responses .
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PMC11791432
The results of clone formation assay and EdU experiment showed that after interfering with ANXA1, the clone formation ability of glioma cells decreased, and the percentage of proliferating cells also decreased significantly, indicating that the cell proliferation ability was weakened.
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PMC9429973
Disease complication is common due to excessive iron overload and sub-optimal chelation.
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PMC11023271
cDNA was synthesized from the RNA preparations using the Maxima H Minus First Strand cDNA Synthesis Kit (Fisher Scientific, #K1651).
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PMC9111184
The monolayers were formed after 16 days.
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PMC11767817
Chen and co-workers showed that curcumin derivative EF24 ((3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone combined with MK-2206 induced ER stress, mitochondrial dysfunction, and apoptosis in gastric cancer cells .
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PMC10547921
DNA damaging agents can destroy DNA structures to kill tumor cells through double-strand breaking, alkylation, chimerism, and cross-linking.
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PMC10506676
All experiments were performed in duplicate, i.e. we have two well for each group (two well for EBNA1 transfected group, two well for control plasmid transfected group).
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PMC11767725
In metabolic disorders, insulin resistance alters sebaceous gland function, skewing the lipid profile toward increased production of saturated fatty acids and decreased levels of unsaturated fatty acids.
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PMC11740207
NDSCs are regulated by several key molecular pathways during differentiation, including the BMP, fibroblast growth factor (FGF), and retinoic acid (RA).
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PMC11535726
Similar to our new species, K.dujuanhuensis also comprises a spherical hyaline mucilaginous sheath.
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PMC11264242
Western blot analysis of the immunopurified products confirmed the presence of BRG1, TLE1 and HDAC1 (Supplementary Figure S4), three major SS18-SSX-binding proteins seen previously.
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PMC10094992
Following SDS-PAGE, proteins were transferred to nitrocellulose, reacted with specific antibodies, and then detected with peroxidase-conjugate secondary antibodies and chemioluminescent ECL reagent.
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PMC11621565
Supplementary Fig. 1, Supplementary Fig. 2).
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PMC3035438
These results suggest that the selection of antigen-specific chicken IgM from the CX13 chimera-derived library allowed the simultaneous selection of chimeric IgG with the same specificity and affinity for the target antigen.
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PMC11394227
The caspase-3 activity assay kit (Beyotime) was used.
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PMC11476106
Within the TME, the extracellular matrix (ECM) forms a complex network of fibrillar proteins, glycoproteins, and proteoglycans, which act as the scaffold for cellular embedding .
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PMC11569208
Cells were incubated at 37 °C and 5% CO2 conditions in a humidified incubator.
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PMC11721064
Paired-end sequencing (150 bp reads) was conducted on an Illumina HiSeq X Ten/NovaSeq 6000 platform.
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PMC11711066
However, the beneficial effects of AS‐IV may be attributed to its steroidal skeleton.
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PMC11604768
e Dual luciferase response curves in HEK293 cells in the presence or absence of 50 nM of the Gαq-specific inhibitor FR900359 (THRB-1, minCMV, rotation 8, spacer set 1; NFKB1, minCMV, rotation 8, spacer set 1).
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PMC4395774
We are aware of other projects that are developing gene therapy for defects in munc 13–4 which is the other major genetic cause of FHL (Cavazzana, personal communication), and thus, it is possible that in time a gene therapy option may be available for the majority of patients affected by FHL.
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PMC11665555
βHB utilization can be achieved through altered biosynthetic or catabolic mechanism, ultimately having a favorable HMGCS2/OXCT1 ratio.
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PMC10758402
Altogether, our findings suggest that combination approaches using DMF and engineered HSV-1 that can maximize anti-tumor immune response warrant further testing.
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PMC10988808
B Xenograft tumor growth volume curves of OE-CCDC25 cells and their corresponding NC cells.
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PMC9429973
Mel dosing based on body surface area raised concerns for patient under- or overdosing in prior report.
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PMC11476106
Concurrent chromosomal copy number alterations are also observed, including gains on chromosomes 1q, 8, 12, or 20 and losses on 16q .
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PMC9429973
Two subjects developed ≤grade-2 immune effector cell-associated neurotoxicity syndrome (ICANS).
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PMC8270637
We subcutaneously transplanted H22 cells, a mouse-derived HCC cell line, to KM mice, and injected mouse-derived TGF-β1 (70ng/mL, 280ng/mL) or normal saline via tail vein three days after inoculation, once a day with the dosage of 5mL/kg.
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PMC11531744
This clinical specimen was donated from a 61-year-old Chinese female patient with advanced ovarian carcinoma.
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PMC9046263
Ct values were normalized to expression of NHA using the delta-delta Ct method.
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PMC6442998
We hypothesized that this lack of sensitivity might be linked to the lower PDE3A expression in GIST48 cells.
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PMC10820104
Herein, we present an independent assignment of the absolute configuration of the known rubrumline I (2) via single-crystal X-ray diffraction analysis through anomalous dispersion for the first time, allowing an unambiguous assignment of the absolute configuration of 2 as 12S and 22S (Figure 4).
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PMC8041314
As a next step, structural markers were searched for that clearly favored triple ABCB1, ABCC1, and ABCG2 inhibition.
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PMC3019555
Anti-GFP was used to immunoprecipitate lysates from MCF7–GFP-tub cells treated overnight with 25 µM 2ME2 or 25 nM TX.
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PMC11347429
Several transcriptome studies on samples from influenza-infected patients have been performed, with most using gene expression arrays (17–33).
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PMC11502327
Zeylenone, a natural cyclohexanthin oxide derived from Uvaria grandiflora Roxb, was shown in a pilot study to reduce the expression of p-JAK and signal transduction and transcriptional activators of the Janus family of tyrosine kinases by increasing the mRNA levels of cytochrome C and apoptosis-inducing factors, promot...
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PMC9250505
The majority of EOC are initially platinum-sensitive but eventually develop resistance.
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