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PMC9856122
In the 19th century, morphine was the first isoquinoline alkaloid isolated from Papaver somniferum .
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PMC11574029
T24 and 5637 cells transfected with sh-NC and sh-NOTCH3 were injected into the tail vein of nude mice to establish a lung metastasis model, observed 5 weeks later.
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PMC11700165
Moreover, the ΔTEL-SYK mutant, in which the dimerization domain was deleted, also strongly phosphorylated SLP-76 (Fig. 4).Fig.
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PMC10891340
Cell is highly in control of ROS production and clearance, and excessive ROS production will lead to ROS exceeding the normal threshold level of the cell.
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PMC3931643
Cyclin D3 protein decreased to varying degrees in all cell lines with both rapamycin and MLN0128 treatment.
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PMC10667689
This product was subjected to qPCR (RealQ Plus 2x Master MixGreen, High ROX; Amplicon, Denmark) for target genes with primers (synthesis: metabion, Germany) listed in Table 1 , alongside the housekeeping gene, β-actin, performed using the Applied Biosystem Real-Time PCR System (USA).
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PMC6450504
The experiments were performed in 5- to 6-week-old female athymic nude mice following protocol 16-1134 R approved by Northeastern University Institutional Animal Care and Use Committee.
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PMC11676169
NaCl concentration in cytoplasmic extracts was adjusted to 150 mM and pre-cleared with Protein G Plus–agarose (sc-2002; Santa Cruz Biotechnology, Dallas, TX, USA) at 4° for 30 min.
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PMC11686380
Sholl test was conducted to quantify branch points of dendrites in (D).
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PMC8316344
In Bel-7404 cells, knocking TRIB2 out aggravated the induced ferroptosis-associated cell death and lipid ROS generation as well as reduced cell viability that is caused by RSL3 and erastin (Fig. 2D–F).
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PMC11731161
Total protein was extracted using RIPA lysis buffer (Beyotime, China).
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PMC11535726
Molecular data further supports the establishment of Kirschsteiniothelialongirostrata as a novel taxon.
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PMC9429973
Image: Summary/Conclusion: This study will assess the efficacy of asciminib in adult pts with newly diagnosed CML-CP vs that of currently approved TKIs.
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PMC6450504
After 4 h of incubation at 37 °C, the cells were harvested, washed and immediately analyzed by a FACSCalibur flow cytometer (Beckton Dickinson, Franklin Lakes, NJ) using a 488 nm blue laser for excitation and FL2 channel (585/42 nm wavelength filter) for recording the rhodamine fluorescence intensity.
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PMC11365427
It was reported that asparagine bioavailability strongly influenced metastatic potential.
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PMC3164356
A difference between human and CHO glycosylation is seen in the lack of expression of MGAT3, which is responsible for the bisecting β(1,4) GlcNAc that occurs on ∼10% of human antibodies. (
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PMC9739791
Rhodaplatin 16, bodipy-based Pt(IV) prodrugs 27 and 28, and cyanine-based Pt(IV) prodrug 29 accumulated primarily in mitochondria, hence damage to mitochondria was the main toxicity mechanism of those prodrugs.
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PMC11726183
To obtain medicines through a unique mode of action or generate a synergistic impact, blending two or more pharmacophoric moieties in a single molecule is a primary strategy for developing drugs.
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PMC9429973
Efficacy data through Week 131, the last data recording within the 2-year Part B period, are reported here.
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PMC9429973
shRNA-mediated knockdown of the 12 candidate genes confirmed their essentiality for NUP98-KDM5A leukemia cell proliferation.
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PMC11486946
Representative images from 6 independent experiments are displayed.
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PMC10887351
Amato et al., in a mouse model of retinopathy, showed increased expression of β3-ARs through the HIF-1 pathway that binds to the enhancer region of the receptor .
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PMC7338939
In addition, AXIN1 is a mediator rather than an apoptosis marker (45) and is necessary for mediating the crosstalk between Wnt/β-catenin signaling cascades (46).
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PMC9429973
Prescribing errors were less overall using eMeds (N=6, 6%) compared to the paper-based system (N=18, 20%).
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PMC8494202
Tumor grade in the CGGA RNA-seq (HR = 2.470; 95%CI = 1.796-3.398, P < 0.001), CGGA microarray (HR = 2.254; 95%CI = 1.305-3.892, P < 0.001), and TCGA RNA-seq (HR = 2.918; 95%CI = 2.289-3.721, P < 0.001) datasets was found to be an independent risk factor for glioma patients (Figures 3(b), 3(d), and 3(f)).
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PMC9429973
While other high-risk cytogenetic abnormalities may account for this adverse prognosis, these kind of cytogenetic alterations are not present in all patients with such an unfavorable outcome.
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PMC11585994
Prolonged chemotherapy or allogeneic hematopoietic stem cell transplantation may be employed to sustain patient benefits.45,46 In the case of T-ALL, high-intensity chemotherapy regimens are commonly used.
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PMC8481254
Colonies from 12 fields of view were counted after 2 weeks of culture.
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PMC11507371
Indeed, we demonstrated a gradual elevation in NF-κB activity with an increasing exposure time to CAP in A431 cells whereas HaCaT cells did not display any changes (Figure 5C).
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PMC9429973
The healthcare costs for patients assigned to the CAR-T strategy included bridging chemotherapy (36.8% of the patients), hospitalization (median length 21.2 days, of which 23% in intensive care), and the price of KTE-X19.
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PMC10452486
Although the affinity of W6/32 for Face-2 of HLA-B questions the validity of using mAb W6/32 to validate the expression of B2m-associated HCs of HLAs, particularly in the light of the observations of Giacomini et al. that confirmed the presence of Face-2 among HLA-C alleles and some alleles of HLA-B in normal and malig...
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PMC10362265
This observation implied a less pronounced impact of the disulfide bond on the stability of the YLDV tetramer, underscoring the contribution of secondary interactions that are mediated by hydrophobic and charged amino acids.
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PMC11578343
All cell lines took approximately 750–1250 ms to transit each zone, resulting in mean applied frequencies of 13, 30, 47, and 65 Hz for zone 1, 2, 3, and 4, respectively, across the three cell lines (Figure 4A,ii).
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PMC10728200
GIST-T1 xenografts were established in 6-week-old male BALB/c nude mice (Shanghai Jiesijie Laboratory Animal Corporation) by inoculating 5 × 10 cells mixed with Matrigel (BD Biosciences) at a 1:1 ratio (volume) into the dorsolateral side.
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PMC11536589
These results indicated that the putative motif was more prominently detected in the DNA that was precipitated after the addition of the antibodies targeting β-catenin or Tcf4 in AsPC1-MR cells (Fig. 5K).
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PMC11628309
Among them, 14-3-3 proteins are a conserved group of eukaryotic proteins involved in various processes, including signal transduction, cell cycle regulation, malignant transformation, stress response, and apoptosis (Fu et al., 2000).
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PMC11779605
Ovarian cancer is a highly heterogeneous disease with multiple distinct histologic types that arise from different organ sites and exhibit unique DNA mutation profiles (27).
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PMC9874064
USP1 protein expression in BEL-7404DPP cells after 48 ​h treatment with different drugs by Western blot.
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PMC11747467
Notably, in patients with liver metastasis, RC48 exhibited better clinical activity and disease control.
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PMC11802929
We next investigated the antigen sequences associated with SCT expression and cell capturing.
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PMC4395774
The concept of using HSC gene transfer to correct immune developmental or function defects has been verified in other models but has not been tested for immune dysregulatory conditions.
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PMC11478724
The RNA expression levels of BAX and Bcl2, indirect targets of hsa-MiR-320a, showed that treatment with PMX up-regulated BAX and down-regulated Bcl2 (P < 0.05). [
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PMC9429973
Aims: This post-hoc analysis aimed to describe the characteristics of patients with CAD who received prior off-label rituximab treatment versus rituximab-naïve patients and present the efficacy of sutimlimab in these subgroups, using pooled data from the Phase 3 CARDINAL and CADENZA (NCT03347422) trials.
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PMC11363012
Serpentine (4), an alkaloid that fluoresces under UV, was used as a marker for the assignment of idioblast cells, a rare cell type (2–3% of the total cell population) that accumulates the majority of the alkaloids.
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PMC8750422
Tumor metastasis was monitored by weekly bioluminescence imaging using the IVIS Lumina III (PerkinElmer, USA).
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PMC10495912
Dose-Response Curves of the MTT Assay in the HepG2 Cell Line Using Thymoquinone (A), hydrogen peroxide (B), and their combination (C).
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PMC10587429
Resuspend CD34 HSCs in DPBS at 2 x 10 cells/mL and immediately inject 100 μL containing 2 x 10 CD34 HSCs into the lateral tail vein of irradiated mice using a 1-cc tuberculin syringe with 30 Gauge needles.
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PMC11787381
The release of terbutaline in the brain, however, appears faster through IN route versus IV route.
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PMC9429973
Treatment regimens were identified by line of therapy and mutually exclusively categorized as rituximab monotherapy (R-mono), bendamustine + rituximab (BR), rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), ibrutinib, or other.
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PMC11615828
The enzymatic reaction was stopped by treating with a sterile‐filtered inactivation solution (composed of 10 mL serum media, 25 mg bovine albumin, and 25 mg trypsin inhibitor; 10 mL serum media includes 0.5 mL FBS, 38.3 mg glucose, and 9.5 mL MEM with Earle's salts without L‐glutamine) at 37 °C in a water bath for 2 mi...
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PMC8414691
A Quantitative analysis of defects; mock (white histograms), DOM-A depleted cells (black histograms).
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PMC10723784
CBD has been shown to have multiple molecular targets such as the regulation of Ca levels, induction of ROS, regulating ATP, and proton leak suggest that the involvement of mitochondria is a CBD cellular mechanism. ,
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PMC11321678
Bulk measurements of the epigenome have detected enhancers that are differentially regulated and super‐enhancers that contribute to inter‐subgroup heterogeneity and enhancer hijacking in MB. , ,
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PMC4277423
A. Cell surface expression of CCR5 on CEMss-CCR5 cells co-transduced with lentiviral vectors expressing Cas9-HA-NLS and one of sgRNA (CR2 or GF1) as compared to mock-transduced CEMss-CCR5 cells.
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PMC7338939
The expression of Notch and Wnt downstream genes and intermediate genes in five selected tumor 15th days post DAPT treatment.
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PMC10222971
On the other hand, naphthoquinones modified at position 2 of the naphthoquinone backbone (2-O-acyl lawsone (4) and 2-O-alkyl lawsone (10), showed certain selectivity among the different cell lines assayed.
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PMC11496491
The pie chart shows the biological process classifications. (
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PMC11680982
combined with endocrine therapy (fulvestrant, 100 mg/kg, i.m.),
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PMC9429973
It seems relevant to study the relationship between the HLA genotype and the probability of alloimmunization of recipients as a result of blood transfusions.
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PMC10196713
Since combined therapy with a platinum agent and taxol is currently considered the gold standard for the treatment of OC, whether A2780cis and OVK18cis cells exhibited resistance to taxol was next investigated.
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PMC7039683
Transgene copy number was estimated by qPCR using a TaqMan probe targeting Shh promoter.
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PMC11794568
Each experiment was repeated independently at least three times.
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PMC10898159
The above suggests promising therapeutic ability in targeting ncRNA and thereby modulating KIT expression warranted future investigation.
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PMC11604768
Our library has likely skewed toward the latter, as many TREs displayed a similar response across each configuration.
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PMC11661024
A flow cytometry analysis was also conducted to confirm apoptosis.
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PMC11046454
Also, the potency of ATP-AptPTK7-CAR-T for ATP-responsive elimination of target PTK7 231 cells could be recovered only by ATP incorporation (Figure 4D).
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PMC11697703
The singularity-based pipeline for automated end-to-end quality control and processing of ATAC-seq data was installed from GitHub (https://github.com/ENCODE-DCC/atac-seq-pipeline).
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PMC9429973
Image: Summary/Conclusion: MRD assessment by MS (EXENT and LC-MS) in PB and NGS in BM serve complementary roles.
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PMC11711127
So far few or no studies have investigated the tolDC synapse, most likely because of the complexity of analysing T-DC synapses in general and that there is a lack of consensus on how to generate tolDC ex vivo (see tolDC section for more information).
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PMC11767582
Then, 10 μL of MTT (5 mg/mL in phosphate-buffered saline, PBS) was added to each well after 2 days of incubation (37 °C, 5% CO2 in a humid atmosphere).
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PMC11429241
Cell migration towards the scaffold was visible on the first day, as all the cells present in the culture migrated towards and attached to the scaffold.
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PMC2118063
Frozen serial sections were stained with anti-BCL6 or PNA and counterstained with hematoxylin.
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PMC9429973
Image: Summary/Conclusion: These results demonstrate that in patients with HES, there are differences in patient and disease characteristics as well as treatment strategies across Europe.
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PMC11643361
Their ability to interact with biological macromolecules may enhance their cytotoxic effects, providing a potential alternative to traditional chemotherapeutics.
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PMC9429973
Results: MDS EB1 was diagnosed in 182 patients (42,1%), and MDS EB2 in 250 patients (57,9%).
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PMC11746948
The quadrate lobe was separated from its attachment with the left lateral lobe to reveal the portal triad.
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PMC11538390
Quantitative PCR revealed much higher binding of H3K27Ac and of IRF6 at MCS-9.7 versus at the negative control locus in iOECs (Fig. 5b, c).
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PMC6114978
Additional preclinical studies are required to evaluate the feasibility of upregulating expression of the Hippo kinases in patients with TAZ/YAP activated sarcomas by modulating proteosomal degradation of MST2, and potentially inhibiting DNA methyltransferases and histone deacetylases.
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PMC11093197
After overnight culture, the medium was replaced with fresh media containing lentivirus and 1 μg/mL polybrene.
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PMC11463018
Metabolic stabilities of 19 and SAHA towards HLM.
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PMC11467800
Extravasation ability of the K562 and K562‐IR cells. (
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PMC11411131
This study shows the inhibitory effect of MeHg on the incorporation of Sec during translation.
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PMC11323699
Overcoming resistance to anti-PARP therapies remains a major challenge in the management of OC.
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PMC8494202
Finally, the absorbance was measured at 490 nm using a microplate reader.
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PMC5941560
These redundant translocation calls were merged if they spanned the same two chromosomes.
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PMC9545474
Molecular structures of complexes 4–8.
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PMC9429973
The depth of immune dysfunction can be influenced by factors such as age, comorbidity, disease status and previous treatment.
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PMC11694066
The concentrations of SN-38, M6620, and SRA-737 evaluated in these assays were lower than that clinically achievable in patients based on the Csd-max described for these compounds [SN-38, Csd-max = 33 nmol/L (25); SRA-737, Csd-max = 1.440 μmol/L (26); and M6620, Csd-max = 740 nmol/L (27)], altogether supporting the rel...
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PMC9398137
Activation of mitochondrial apoptosis is tightly controlled by members of B-cell leukemia/lymphoma-2 (BCL2) family proteins via their homotypic and heterotypic interactions.
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PMC11087766
These results indicate that protein trafficking into the phage nucleus likely involves a recognition surface rather than an N- or C-terminal signal sequence as found in many other import systems (18, 20, 22, 25, 27).
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PMC11489351
In normal cells, pyruvate is primarily processed through pyruvate dehydrogenase (PDH) to generate AcCoA for citric acid cycling and oxidative phosphorylation, while a shift to proliferative (glycolytic) metabolism is marked by conversion of pyruvate to lactate via LDHA (61).
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PMC5035325
One representative experiment out of three performed experiments is shown in each case Combinatorial targeted therapy to the EGFR and NeuGcGM3 ganglioside in two lung metastasis models of mice: Lewis lung carcinoma (3LL-D122) in C57BL/6 (a-c) and mammary carcinoma (4T1) in BALB/c (d-g) .
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PMC7519871
Combination indices show that administration of WDL in combination with the cisplatin resulted in nearly to synergistic effect at all the sequences of combined drug administration; this effect was more remarkable when either of the two drugs is used 4 hours before the other (Table 2 and Supplementary Table).
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PMC11684269
The property of immunological memory within adaptive immune systems endows organisms with a rapid response when future immune scenarios emerge.
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PMC11588008
Previous manuscripts report that MSC can repair tissue damage such as POF and osteoarthritis .
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PMC5941560
Genome coverage was calculated with the genomecov command from the BEDtools software package version 2.25.0 (http://bedtools.readthedocs.io/en/stable/index.html), and average coverage was calculated as the number of mapped bases divided by the total number of bases in the reference genome.
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PMC9429973
ICANS occurred in 3 patients (15%; all grade 1/2); 1 patient had facial paralysis (grade 2).
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PMC11420784
Combined with the conclusion from Miao et al that 6 hpi is the time point when most UPEC is exocytosed by lysosomes , we speculated that PldA may also participate in the escape of UPEC from lysosomes.
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PMC11638255
A representative gating strategy is presented in Supplementary Fig. 8d.
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PMC8345486
cis-Diammineplatinum(II) dichloride (cisplatin, 99.99% P4394) and gemcitabine hydrochloride European Pharmacopeia (EP) Reference Standard were purchased from Sigma-Aldrich (St. Louis, MO, USA).
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