OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10490530	The above results were further validated by performing a ChIP assay to understand the binding ability of p53 and NF-κB on the PIK3CA promoter in A2780 and A2780 p53 overexpressed cell lines treated with doxorubicin, TNFα, or both modulators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11770130	f Individual ceramide levels in the serum of control and Ntsr2 AKO mice (n = 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "Individual", "ceramide", "levels", ...
PMC11767725	Future research will need to explore long-term efficacy, ideal phage combinations, and potential synergy with established acne therapies such as topical retinoids or benzoyl peroxide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656048	Nrf2 is a specific regulator of antioxidant responses and plays a vital role in mitigating lipid peroxidation and ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nrf2", "is", "a", "specific", ...
PMC6642070	Several theories have been proposed, including sarcolemmal cholesterol reduction, isoprenoid depletion and mitochondrial dysfunction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "theories", "have", "been", "proposed", ",",...
PMC11720808	Statistical comparisons between two groups were analyzed by Student’s t-tests. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "comparisons", "between", "two", "groups", "were", "analyzed", "by", ...
PMC11269792	Expression levels of circRNA, mRNA, and miRNA were calculated by the 2 method and standardized to GAPDH or U6.Table 1Primers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", ...
PMC8193046	We propose a ranking methodology to maximally increase the impact of secondary positive substructures in combination with primary positive hits for the best possible multitarget ABCB1, ABCC1, and ABCG2 inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A. C. Silva-Pinto, R. Colombatti, A. Pasanisi, F. Arcioni, L. DeBonnett, W. Soliman, R. Sarkar, R. D. Cançado Regional Blood Center, Department of Medical Imaging, Hematology and Oncology, Ribeirão Preto School of Medicine, São Paulo, Brazil; Azienda Ospedale-Università di Padova, Padova; Centro Microcitemia-UOC, Emato...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5173112	Recently, IL-8 was shown to be involved in the renewal of colorectal cancer stem cells and an IL-8 neutralizing antibody was shown to inhibit sphere formation in vitro as well as colon cancer growth in vivo .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	In the case of non-enzymatic optical biosensors, the MC-LR detection occurs via charge distribution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "case", "of", "non-enzymatic", "optical", "bios...
PMC11634794	LAMPs play crucial roles in various cellular processes including phagocytosis, autophagy, lipid transport, and senescence (8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LAMPs", "play", "crucial", ...
PMC9429973	NGF was discordant in all cases (EXENT QIP-MS(+)/NGF(-)), except in 1 patient at +28 days and 3 pts at +100 days, reflecting the MP persistence in the absence of BM disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This validates the therapeutic potential of interfering with the mechanisms responsible for SETD2 loss.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "validates", "the", "therapeutic", "potential", "of", "interfer...
PMC10530622	Therefore, to appropriately study the dose-effect relationship, a compilation of oxalate concentrations in different human populations and also of the variability that exists between people was considered useful and is presented in the next section.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683130	SerpinB7 deficiency can cause epidermal barrier dysfunction in IMQ-induced psoriasis like models (85).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SerpinB7", "deficiency", "can", "cause", "epidermal", "barrier", ...
PMC11023271	The solution retained in the column had a smaller volume than the original material, which supposedly contain molecules larger than the cutoff.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9444294	Lysates were quantified by Pierce™ BCA Protein Assay Kit (Thermo Scientific, #23225, Waltham, MA, USA) and 20 µg was used for Western blot experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10024132	We postulated that utilizing γ9δ2 T cells instead of long-lasting αβ T cells to secrete blinatumomab might strike a balance between the advantages and disadvantages of current therapies and provide additional benefits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9856122	Recently, the role of phytochemicals in anti-inflammatory activity has also got considerable scientific attention for possible intervention in viral infections including SARS-CoV-2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recentl...
PMC10728200	Colocalization of STUB1 (green) and GPX4 (red) in cells appears yellow in the merged images.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colocalization", "of", "STUB1", "...
PMC10203589	Wnt/β-catenin signaling enhances FGF18 expression and promotes tumor progression in CRC, HCC, lung cancer, and breast cancer (32, 79, 115, 126).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10748106	Finally, ten simple iridoids (D9, D107, D35, D36, D55, D56, D58, D60, D61, and D62) are proposed as potential cytotoxic agents against the HeLa cell line based on their predicted IC50 value and electrostatic features.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472569	A canonical ABC transporter consists of two highly variable transmembrane domains (TMDs) embedded in the membrane bilayer and two highly conserved nucleotide-binding domains (NBDs) located in the cytoplasm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417	Scale bars = 50 μm Primary and immortalized MDECs on adherent culture plates were visualized on a CKX41 phase-ring inverted light microscope (Olympus, Waltham, MA) and imaged using an Infinity2-1R USB Microscopy Camera (Lumenera, Ottawa, ON).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The focused CRISPR/Cas9-screening identified six writers/erasers/readers of RNA modifications that were essential for myeloma cell survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "The", "focused", "CRIS...
PMC9429973	The whole blood adhesion assays and platelets aggregation study on hemolysate-preconditioned HUVECs were performed in continuous flow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "whole", "blood", "adhesion", "assays", ...
PMC11194678	Then we wondered whether STAU1 condensates could be recognized by the autophagy degradation system, thus competing for the clearance machinery with other biomolecular condensates or aggregates (e.g., HTT Q111 aggregates in HD STHdh cells; Fig. 1 D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	ASH 2021.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "ASH", "2021", "." ] } ]
PMC6600253	However, this highly regulated process can be disrupted when DNA replication proceeds in cancer cells with elevated rates of genomic instability and increased proliferative capacities .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11687167	ATP-binding cassette subfamily G 1 (ABCG1) is highly expressed in a variety of immune cells, including macrophages and T lymphocytes, and plays a role in the intracellular transport of cholesterol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	The following drugs and reagents were used for live imaging experiments: NucBlue (Hoechst33342; DNA marker; Thermo Fischer, R37605), AACOCF3 (selective phospholipase A2 inhibitor; Tocris, 1462-5), CK666 (selective ARP2/3 inhibitor; Tocris, 3950), BI605906 (selective IKKβ inhibitor; Tocris, 53001) and PGE2 (Stem Cell, 7...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	E, F) USP2-knockout MM.1S (E) and RPMI 8226 (F) cells were treated with MG132 (20 μmol/L).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9386809	Anticancer activity of ferrocene-appended bis(indolyl)methane (4g, inset figure) in comparison to control at different time intervals and at various concentrations (1, 5, 10, 15, and 10 μM) of the sample against the A-172 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A single cilta-cel infusion was administered at a target dose of 0.75×10 CAR+ viable T cells/kg 5-7 days after lymphodepletion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11267830	Indisulam, an aryl sulfonamide drug, functions as a “molecular glue” by connecting the U2AF-related splicing factor RBM39 to the CRL4-DCAF15 E3 ubiquitin ligase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Target identification and screening using a species-specific, 3D model that can incorporate primary patient cells will reduce dependence on animal models and may accelerate translational research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11486946	The gap difference between the in-focus positions determined by the device and human eyes can be adjusted by setting an offset value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gap",...
PMC11737091	p < 0.05; , p < 0.01; *, p < 0.001 The expression pattern of DBF4. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8978939	This work comprises the functional characterization of two novel variants of the VHL gene (P138R and L163R) that have been described in our center in patients with VHL disease by in vitro, in vivo, and in silico approaches.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	The cells were then reseeded again and incubated for 7 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "reseeded", "again", "and", "incubated", "for", "7", ...
PMC10196713	In addition to mutations within a set of cancer driver genes in various types of cancers, alterations in copy numbers and/or epigenetic modulations of particular genes are known to be crucial for the progression of several types of cancers, including OC (35–37).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	These results further support the PK/PD similarity of ABP 959 with eculizumab RP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "further", "support", "the", "PK/PD", "similarity", "of"...
PMC11714165	Quantification of apoptosis in the tumor tissues in E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "apoptosis", "in", "the", "tumor", "tissues", "in", "E", ")", "." ...
PMC3765139	Nine heterogeneous metastatic melanoma cell lines including D10 and WM115 were studied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Nine", "heterogeneous", "metastatic", "melanoma", "cell", "lines", "includ...
PMC11371747	CEM-7A cells (2 × 10) were suspended in 1 mL HBSS and the assay was initiated by addition of 25 μL 200 μM [H]-l-LV; 5,000 pmol (i.e., 5 μM final concentration).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: In this study ‘real-world’ data were drawn from the Adelphi DLBCL Disease Specific Programme™ (DSP), a point-in-time survey of clinicians and their next 6 presenting patients with DLBCL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7802142	Subsequently, the extruded ReN-NV were purified in a layer between 10% and 50% (v/v) iodoxanol by ultracentrifugation (L-80XP, Bechman Coulter, USA) at 100,000×g for 2 h. The ReN-NV pellet was resuspended in PBS after a wash step by another ultracentrifugation with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients showed a better prognosis (longer OS, lower AML transformation rate) when categorized into the proposed SF3B1 entity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "showed", ...
PMC10197932	In order to clarify how ultrasound affects the survival of healthy lymphocytes and leukemic myeloid cell lines, we evaluated early and late apoptosis/necrosis events at 30 min and 24 hours after sonication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: 2465 consecutive neutropenic children were enrolled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "2465", "consecutive", "neutropenic", "children", "were", "enrolled", "." ] } ]
PMC9429973	No adverse events were reported as related to tabelecleucel by the treating physician.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "adverse", "events", "were", "reported", "as", "related", "to", ...
PMC11194678	Left: Representative images showing co-localization of mCherry-STAU1 5KE (red) with RNA (green) within STAU1 5KE condensate (dashed box) in COS7 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	These results led to the hypothesis that the hormonal changes in pregnancy could probably explain the variation of β2- and β3-AR expression, their functionality and affinity compared with non-pregnant myometrium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705630	Cells in serum-free medium were added to upper chamber.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "in", "serum-free", "medium", "were", "added", "to", "upper", "chamber", "." ] } ]
PMC11615101	The RAFLS cells were validated by morphological observation, vimentin expression, and p65 protein level (Supplementary data Figure S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RAFLS...
PMC11739484	Furthermore, our analysis demonstrated a significant (p-value < 0.05) inverse correlation between MMP expression levels and promoter methylation status, suggesting a potential regulatory role of DNA methylation in MMP dysregulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11661040	Scale bar: 200 μm. (*	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "200", "μm", ".", "(", "*" ] } ]
PMC9429973	Each timepoint of management decision regarding biopsy performance was considered as a separate “episode of R/R lymphoma”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "timepoint", "of", "manage...
PMC9429973	Magnetic resonance imaging using T2-star (MRIT2*) is a reliable and safe non-invasive method for accurate assessment of iron overload in the heart and the liver Splectomy increase the risk of morbidity and morbidity in thalassemia (TM & T I) Endocrine complication is common problem in thalassemia with increased in the ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782508	Azurin improves treatment response in lung, breast, cervical, colon, and oral squamous carcinoma cells, making them more susceptible to drugs like gefitinib, erlotinib, paclitaxel, doxorubicin, 5-fluorouracil, and etoposide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10523483	H1.2 deficiency suppressed tumor progression and led to higher oxidative stress in vivo. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H1.2", "deficiency", "suppressed", "tumor", "progression", "and", "led...
PMC9429973	Among pts still on treatment after cons-1, 55/56 (98%) pts achieved CR, 50/55 (91%) reached MRD negativity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8140214	D-glucose had various effects on intracellular antioxidant defense atdifferent doses and time-points and quercetin could attenuate oxidative stress and modulate antioxidant defenses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D-glucose", ...
PMC11348300	The comparative study presented in Fig. 5 was lead using 10 mice per tumor line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "comparative", "study", "presented", "in", "Fig.", "5...
PMC11055323	SS, SS18-SSX1 The exclusion of HDACS further intrigues us to probe the underlying mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SS", ",", "SS18-SSX1", "The", "exclusion", "of", "HDACS", ...
PMC11350568	Remarkably, cells treated with AptG-1 exhibited the lowest fluorescence intensity in flow cytometry, indicative of the effective degradation of the PTK7 protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	The median PLT count at the start of LZ therapy was 19×10/L in both groups (range 5-49×10/L in the AL cohort, 5-35×10/L in the ASCT group), while the median treatment duration was 8 days in both groups (range 2-15 days in the AL cohort, 3-12 days in the ASCT cohort).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084	The final drug concentrations ranged from 3–15 nM after addition of BPR0L075 or paclitaxel containing medium in replicates of 12 wells per condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11052306	Dendrimer 2-G3 moderately activated caspase-3, moderately initiating the apoptotic cascade leading to cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dendrimer", "2-G3", "moderately", "activated", "caspase-3", ",", ...
PMC11461833	Conversely, STXBP5 depletion exhibited the opposite effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "STXBP5", "depletion", "exhibited", "the", "opposite", "effects", "." ] } ]
PMC10419319	Overall, these results suggest that isoalantolactone suppresses glycolysis and sensitizes cisplatin-resistant cells to cisplatin by inducing mitochondria-mediated apoptosis and caspase activation in A2780 and SNU-8 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLin...
PMC9429973	Especially immunocompromised patients, such as ones suffering from malignant diseases, are at a higher risk of severe influenza virus infection, thus leading to increased morbidity and mortality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Subjects achieving double-negativity after standard of care treatment were excluded from this analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subjects", "achieving", "double-negativity", "after", "standard", "of", "care", ...
PMC10047551	In NSCLC cell lines, we identified specific PD-L1 CpG sites with methylation levels inversely correlated with PD-L1 mRNA expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "NSCLC", "cell", ...
PMC9388315	The Cinnamon plant, known as Cinnamon and Cinnamomum, belongs to the Lauraceae family and has been used as a spice in many countries for centuries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	Stem cell–based therapeutics have recently been investigated in a variety of immune-mediated inflammatory disorders (IMIDs), including IBD .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stem", "cell...
PMC8701144	An association between APC and E1B-55k would be compatible with the observed clustering of key WNT signaling components in the E1B-55k aggregates; however, APC has not been detected as a direct E1B-55k interaction partner in previous studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9684669	Research on patients with ovarian cancer has found that high levels of ABCB1 expression are inversely related to chemotherapy response and progression-free survival (47).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9412887	Compared with chemotherapy, targeted therapies exhibit superiorities in efficacy and safety, and is thus becoming the mainstream of clinical cancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compare...
PMC10335954	Herein, in order to further investigate the carcinogenic role of TRIP13 in gastric malignancy, we proceeded with experiments and bioinformatic analyses to explore potential downstream genes of TRIP13 and preliminarily demonstrated the carcinogenic functions of TRIP13 in gastric malignant cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7602170	The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is a critical survival pathway for cell proliferation, apoptosis, autophagy and translation in neoplasms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7229095	Almost all the wells in CDM2 show the growth of mini-pools is too high because an excessive growth ratio per well may lead to a dilution with non-producer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394227	We discounted the hypothesis that increased ER content in CHO cells was responsible for the overexpression of mAbs, given that the observed rise in ER content in CHO-PAb was relatively small.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7022782	These may have a positive effect on NPs uptake; indeed, as reported in our previous work, spherical-shaped particles have a higher probability of entering the cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	Never smokers were defined as persons who had smoked fewer than 100 cigarettes in their lifetimes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Never", "smokers", "were", "defined", "as", "persons",...
PMC9429973	The combination of mutational data from LN and ctDNA improved DLBCL assignment to a specific cluster, thus classifying 48.7% (36/74) of cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9878562	Tumors were fixed for 48h in a solution of 4% paraformaldehyde and Vibratome sections stained overnight with anti-hCD19 (mAb HIB19) anti-mPDPN (mAb 8.1.1) and anti-mCD31 (mAb MEC13.3). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640247	On the contrary, neurons expressing RAC3-Q61L showed phenotypes consistent with activated signaling, including rounded cell morphology and lamellipodia formation, leading to increased cell solidity and impaired differentiation (Figure 2A–C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10006224	Cohesin-STAG1 binds at/near CTCF sites while cohesin-STAG2 is loaded elsewhere and requires NIPBL to reach them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cohesin-STAG1", "binds", "at/near", "CTCF", "sites", "...
PMC9847912	To quantify infectious virus production, the CEMss assay plates were thawed for approximately 30 min at 37°C, 5% CO2, and samples of the CEMss cultures (30 μl per well) were transferred to MAGIC-5A cells that had been seeded one day prior in 96-well plates as described above for the CEMss titration assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11514418	The exclusion criteria included: (1) Patients with a history of other malignant tumors; or (2) Patients previously receiving anti-tumor treatments such as radiotherapy, chemotherapy, or targeted therapy before our GS chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742047	Sphingolipids, particularly phosphosphingolipids (SM), are involved in several steps of different cellular pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sphingolipids", ",", "particularly", "phosphosphingolip...
PMC10887351	The beneficial effects of β3-ARs blockade on the immune system and tumor outcome could represent a new approach to treat cancer immune-editing, and it could be an efficient therapy for melanoma treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11337594	A375 cells were treated with TER (2.0 µg/ml) to detect differences in the distribution of mitochondrial and intracytoplasmic proteins between the experimental and control groups (n = 3). (	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	It is well known that hypoxic conditions can alter cellular metabolism, promote a shift from oxidative phosphorylation to glycolysis , and reduce ROS generation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10376064	One hemisphere was kept in paraformaldehyde (PFA 4% in PBS), the other on snap frozen in liquid nitrogen and later transferred to −80 °C (for protein extraction).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502443	Interestingly, we observed the most pronounced biased agonism for tirzepatide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "we", "observed", "the", "most", "pronounced", "biased", "agonism", ...
PMC10667689	Furthermore, since in vivo LSCs directly interact with bone marrow niche and cells and not only affect them but also are affected by them, co-culturing AML cells with bone-marrow-derived adipocytes and assessing the effect of TIM-3/Gal-9 interaction on leukemic cells and adipocytes can be a subject of interest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Given that these were selected for their potential to recognize divergent HIV-1 quasispecies in patients and facilitate elimination from infected hosts , the comparative superiority of TatDE represents an advance in CRISPR therapy as a strategy for HIV-1 elimination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10490530

The above results were further validated by performing a ChIP assay to understand the binding ability of p53 and NF-κB on the PIK3CA promoter in A2780 and A2780 p53 overexpressed cell lines treated with doxorubicin, TNFα, or both modulators.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...

PMC11770130

f Individual ceramide levels in the serum of control and Ntsr2 AKO mice (n = 6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "Individual", "ceramide", "levels", ...

PMC11767725

Future research will need to explore long-term efficacy, ideal phage combinations, and potential synergy with established acne therapies such as topical retinoids or benzoyl peroxide.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11656048

Nrf2 is a specific regulator of antioxidant responses and plays a vital role in mitigating lipid peroxidation and ferroptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nrf2", "is", "a", "specific", ...

PMC6642070

Several theories have been proposed, including sarcolemmal cholesterol reduction, isoprenoid depletion and mitochondrial dysfunction .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "theories", "have", "been", "proposed", ",",...

PMC11720808

Statistical comparisons between two groups were analyzed by Student’s t-tests. *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "comparisons", "between", "two", "groups", "were", "analyzed", "by", ...

PMC11269792

Expression levels of circRNA, mRNA, and miRNA were calculated by the 2 method and standardized to GAPDH or U6.Table 1Primers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", ...

PMC8193046

We propose a ranking methodology to maximally increase the impact of secondary positive substructures in combination with primary positive hits for the best possible multitarget ABCB1, ABCC1, and ABCG2 inhibition.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

A. C. Silva-Pinto, R. Colombatti, A. Pasanisi, F. Arcioni, L. DeBonnett, W. Soliman, R. Sarkar, R. D. Cançado Regional Blood Center, Department of Medical Imaging, Hematology and Oncology, Ribeirão Preto School of Medicine, São Paulo, Brazil; Azienda Ospedale-Università di Padova, Padova; Centro Microcitemia-UOC, Emato...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5173112

Recently, IL-8 was shown to be involved in the renewal of colorectal cancer stem cells and an IL-8 neutralizing antibody was shown to inhibit sphere formation in vitro as well as colon cancer growth in vivo .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11474209

In the case of non-enzymatic optical biosensors, the MC-LR detection occurs via charge distribution.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "case", "of", "non-enzymatic", "optical", "bios...

PMC11634794

LAMPs play crucial roles in various cellular processes including phagocytosis, autophagy, lipid transport, and senescence (8).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LAMPs", "play", "crucial", ...

PMC9429973

NGF was discordant in all cases (EXENT QIP-MS(+)/NGF(-)), except in 1 patient at +28 days and 3 pts at +100 days, reflecting the MP persistence in the absence of BM disease.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

This validates the therapeutic potential of interfering with the mechanisms responsible for SETD2 loss.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "validates", "the", "therapeutic", "potential", "of", "interfer...

PMC10530622

Therefore, to appropriately study the dose-effect relationship, a compilation of oxalate concentrations in different human populations and also of the variability that exists between people was considered useful and is presented in the next section.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11683130

SerpinB7 deficiency can cause epidermal barrier dysfunction in IMQ-induced psoriasis like models (85).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SerpinB7", "deficiency", "can", "cause", "epidermal", "barrier", ...

PMC11023271

The solution retained in the column had a smaller volume than the original material, which supposedly contain molecules larger than the cutoff.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC9444294

Lysates were quantified by Pierce™ BCA Protein Assay Kit (Thermo Scientific, #23225, Waltham, MA, USA) and 20 µg was used for Western blot experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10024132

We postulated that utilizing γ9δ2 T cells instead of long-lasting αβ T cells to secrete blinatumomab might strike a balance between the advantages and disadvantages of current therapies and provide additional benefits.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9856122

Recently, the role of phytochemicals in anti-inflammatory activity has also got considerable scientific attention for possible intervention in viral infections including SARS-CoV-2 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recentl...

PMC10728200

Colocalization of STUB1 (green) and GPX4 (red) in cells appears yellow in the merged images.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colocalization", "of", "STUB1", "...

PMC10203589

Wnt/β-catenin signaling enhances FGF18 expression and promotes tumor progression in CRC, HCC, lung cancer, and breast cancer (32, 79, 115, 126).

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PMC10748106

Finally, ten simple iridoids (D9, D107, D35, D36, D55, D56, D58, D60, D61, and D62) are proposed as potential cytotoxic agents against the HeLa cell line based on their predicted IC50 value and electrostatic features.

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PMC11472569

A canonical ABC transporter consists of two highly variable transmembrane domains (TMDs) embedded in the membrane bilayer and two highly conserved nucleotide-binding domains (NBDs) located in the cytoplasm.

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PMC11566417

Scale bars = 50 μm Primary and immortalized MDECs on adherent culture plates were visualized on a CKX41 phase-ring inverted light microscope (Olympus, Waltham, MA) and imaged using an Infinity2-1R USB Microscopy Camera (Lumenera, Ottawa, ON).

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PMC9429973

Results: The focused CRISPR/Cas9-screening identified six writers/erasers/readers of RNA modifications that were essential for myeloma cell survival.

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PMC9429973

The whole blood adhesion assays and platelets aggregation study on hemolysate-preconditioned HUVECs were performed in continuous flow.

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PMC11194678

Then we wondered whether STAU1 condensates could be recognized by the autophagy degradation system, thus competing for the clearance machinery with other biomolecular condensates or aggregates (e.g., HTT Q111 aggregates in HD STHdh cells; Fig. 1 D).

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PMC9429973

ASH 2021.

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PMC6600253

However, this highly regulated process can be disrupted when DNA replication proceeds in cancer cells with elevated rates of genomic instability and increased proliferative capacities .

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PMC11687167

ATP-binding cassette subfamily G 1 (ABCG1) is highly expressed in a variety of immune cells, including macrophages and T lymphocytes, and plays a role in the intracellular transport of cholesterol.

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PMC11224020

The following drugs and reagents were used for live imaging experiments: NucBlue (Hoechst33342; DNA marker; Thermo Fischer, R37605), AACOCF3 (selective phospholipase A2 inhibitor; Tocris, 1462-5), CK666 (selective ARP2/3 inhibitor; Tocris, 3950), BI605906 (selective IKKβ inhibitor; Tocris, 53001) and PGE2 (Stem Cell, 7...

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PMC11725127

E, F) USP2-knockout MM.1S (E) and RPMI 8226 (F) cells were treated with MG132 (20 μmol/L).

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PMC9386809

Anticancer activity of ferrocene-appended bis(indolyl)methane (4g, inset figure) in comparison to control at different time intervals and at various concentrations (1, 5, 10, 15, and 10 μM) of the sample against the A-172 cell line.

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PMC9429973

A single cilta-cel infusion was administered at a target dose of 0.75×10 CAR+ viable T cells/kg 5-7 days after lymphodepletion.

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PMC11267830

Indisulam, an aryl sulfonamide drug, functions as a “molecular glue” by connecting the U2AF-related splicing factor RBM39 to the CRL4-DCAF15 E3 ubiquitin ligase.

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PMC9429973

Target identification and screening using a species-specific, 3D model that can incorporate primary patient cells will reduce dependence on animal models and may accelerate translational research.

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PMC11486946

The gap difference between the in-focus positions determined by the device and human eyes can be adjusted by setting an offset value.

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PMC11737091

p < 0.05; **, p < 0.01; ***, p < 0.001 The expression pattern of DBF4. (

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PMC8978939

This work comprises the functional characterization of two novel variants of the VHL gene (P138R and L163R) that have been described in our center in patients with VHL disease by in vitro, in vivo, and in silico approaches.

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PMC11701801

The cells were then reseeded again and incubated for 7 days.

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PMC10196713

In addition to mutations within a set of cancer driver genes in various types of cancers, alterations in copy numbers and/or epigenetic modulations of particular genes are known to be crucial for the progression of several types of cancers, including OC (35–37).

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PMC9429973

These results further support the PK/PD similarity of ABP 959 with eculizumab RP.

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PMC11714165

Quantification of apoptosis in the tumor tissues in E).

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PMC3765139

Nine heterogeneous metastatic melanoma cell lines including D10 and WM115 were studied.

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PMC11371747

CEM-7A cells (2 × 10) were suspended in 1 mL HBSS and the assay was initiated by addition of 25 μL 200 μM [H]-l-LV; 5,000 pmol (i.e., 5 μM final concentration).

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PMC9429973

Methods: In this study ‘real-world’ data were drawn from the Adelphi DLBCL Disease Specific Programme™ (DSP), a point-in-time survey of clinicians and their next 6 presenting patients with DLBCL.

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PMC7802142

Subsequently, the extruded ReN-NV were purified in a layer between 10% and 50% (v/v) iodoxanol by ultracentrifugation (L-80XP, Bechman Coulter, USA) at 100,000×g for 2 h. The ReN-NV pellet was resuspended in PBS after a wash step by another ultracentrifugation with PBS.

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PMC9429973

Patients showed a better prognosis (longer OS, lower AML transformation rate) when categorized into the proposed SF3B1 entity.

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PMC10197932

In order to clarify how ultrasound affects the survival of healthy lymphocytes and leukemic myeloid cell lines, we evaluated early and late apoptosis/necrosis events at 30 min and 24 hours after sonication.

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PMC9429973

Methods: 2465 consecutive neutropenic children were enrolled.

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PMC9429973

No adverse events were reported as related to tabelecleucel by the treating physician.

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PMC11194678

Left: Representative images showing co-localization of mCherry-STAU1 5KE (red) with RNA (green) within STAU1 5KE condensate (dashed box) in COS7 cells.

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PMC10887351

These results led to the hypothesis that the hormonal changes in pregnancy could probably explain the variation of β2- and β3-AR expression, their functionality and affinity compared with non-pregnant myometrium.

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PMC11705630

Cells in serum-free medium were added to upper chamber.

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PMC11615101

The RAFLS cells were validated by morphological observation, vimentin expression, and p65 protein level (Supplementary data Figure S1).

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PMC11739484

Furthermore, our analysis demonstrated a significant (p-value < 0.05) inverse correlation between MMP expression levels and promoter methylation status, suggesting a potential regulatory role of DNA methylation in MMP dysregulation.

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PMC11661040

Scale bar: 200 μm. (*

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PMC9429973

Each timepoint of management decision regarding biopsy performance was considered as a separate “episode of R/R lymphoma”.

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PMC9429973

Magnetic resonance imaging using T2-star (MRIT2*) is a reliable and safe non-invasive method for accurate assessment of iron overload in the heart and the liver Splectomy increase the risk of morbidity and morbidity in thalassemia (TM & T I) Endocrine complication is common problem in thalassemia with increased in the ...

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PMC11782508

Azurin improves treatment response in lung, breast, cervical, colon, and oral squamous carcinoma cells, making them more susceptible to drugs like gefitinib, erlotinib, paclitaxel, doxorubicin, 5-fluorouracil, and etoposide.

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PMC10523483

H1.2 deficiency suppressed tumor progression and led to higher oxidative stress in vivo. (

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PMC9429973

Among pts still on treatment after cons-1, 55/56 (98%) pts achieved CR, 50/55 (91%) reached MRD negativity.

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PMC8140214

D-glucose had various effects on intracellular antioxidant defense atdifferent doses and time-points and quercetin could attenuate oxidative stress and modulate antioxidant defenses.

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PMC11348300

The comparative study presented in Fig. 5 was lead using 10 mice per tumor line.

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PMC11055323

SS, SS18-SSX1 The exclusion of HDACS further intrigues us to probe the underlying mechanisms.

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PMC11350568

Remarkably, cells treated with AptG-1 exhibited the lowest fluorescence intensity in flow cytometry, indicative of the effective degradation of the PTK7 protein.

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PMC9429973

The median PLT count at the start of LZ therapy was 19×10/L in both groups (range 5-49×10/L in the AL cohort, 5-35×10/L in the ASCT group), while the median treatment duration was 8 days in both groups (range 2-15 days in the AL cohort, 3-12 days in the ASCT cohort).

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PMC3675084

The final drug concentrations ranged from 3–15 nM after addition of BPR0L075 or paclitaxel containing medium in replicates of 12 wells per condition.

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PMC11052306

Dendrimer 2-G3 moderately activated caspase-3, moderately initiating the apoptotic cascade leading to cell death.

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PMC11461833

Conversely, STXBP5 depletion exhibited the opposite effects.

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PMC10419319

Overall, these results suggest that isoalantolactone suppresses glycolysis and sensitizes cisplatin-resistant cells to cisplatin by inducing mitochondria-mediated apoptosis and caspase activation in A2780 and SNU-8 cells.

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PMC9429973

Especially immunocompromised patients, such as ones suffering from malignant diseases, are at a higher risk of severe influenza virus infection, thus leading to increased morbidity and mortality.

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PMC9429973

Subjects achieving double-negativity after standard of care treatment were excluded from this analysis.

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PMC10047551

In NSCLC cell lines, we identified specific PD-L1 CpG sites with methylation levels inversely correlated with PD-L1 mRNA expression.

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PMC9388315

The Cinnamon plant, known as Cinnamon and Cinnamomum, belongs to the Lauraceae family and has been used as a spice in many countries for centuries.

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PMC11519077

Stem cell–based therapeutics have recently been investigated in a variety of immune-mediated inflammatory disorders (IMIDs), including IBD .

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PMC8701144

An association between APC and E1B-55k would be compatible with the observed clustering of key WNT signaling components in the E1B-55k aggregates; however, APC has not been detected as a direct E1B-55k interaction partner in previous studies .

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PMC9684669

Research on patients with ovarian cancer has found that high levels of ABCB1 expression are inversely related to chemotherapy response and progression-free survival (47).

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PMC9412887

Compared with chemotherapy, targeted therapies exhibit superiorities in efficacy and safety, and is thus becoming the mainstream of clinical cancer therapy.

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PMC10335954

Herein, in order to further investigate the carcinogenic role of TRIP13 in gastric malignancy, we proceeded with experiments and bioinformatic analyses to explore potential downstream genes of TRIP13 and preliminarily demonstrated the carcinogenic functions of TRIP13 in gastric malignant cells.

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PMC7602170

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is a critical survival pathway for cell proliferation, apoptosis, autophagy and translation in neoplasms.

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PMC7229095

Almost all the wells in CDM2 show the growth of mini-pools is too high because an excessive growth ratio per well may lead to a dilution with non-producer cells.

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PMC11394227

We discounted the hypothesis that increased ER content in CHO cells was responsible for the overexpression of mAbs, given that the observed rise in ER content in CHO-PAb was relatively small.

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PMC7022782

These may have a positive effect on NPs uptake; indeed, as reported in our previous work, spherical-shaped particles have a higher probability of entering the cancer cells .

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PMC7887261

Never smokers were defined as persons who had smoked fewer than 100 cigarettes in their lifetimes.

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PMC9429973

The combination of mutational data from LN and ctDNA improved DLBCL assignment to a specific cluster, thus classifying 48.7% (36/74) of cases.

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PMC9878562

Tumors were fixed for 48h in a solution of 4% paraformaldehyde and Vibratome sections stained overnight with anti-hCD19 (mAb HIB19) anti-mPDPN (mAb 8.1.1) and anti-mCD31 (mAb MEC13.3). (

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PMC11640247

On the contrary, neurons expressing RAC3-Q61L showed phenotypes consistent with activated signaling, including rounded cell morphology and lamellipodia formation, leading to increased cell solidity and impaired differentiation (Figure 2A–C).

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PMC10006224

Cohesin-STAG1 binds at/near CTCF sites while cohesin-STAG2 is loaded elsewhere and requires NIPBL to reach them.

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PMC9847912

To quantify infectious virus production, the CEMss assay plates were thawed for approximately 30 min at 37°C, 5% CO2, and samples of the CEMss cultures (30 μl per well) were transferred to MAGIC-5A cells that had been seeded one day prior in 96-well plates as described above for the CEMss titration assay.

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PMC11514418

The exclusion criteria included: (1) Patients with a history of other malignant tumors; or (2) Patients previously receiving anti-tumor treatments such as radiotherapy, chemotherapy, or targeted therapy before our GS chemotherapy.

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PMC11742047

Sphingolipids, particularly phosphosphingolipids (SM), are involved in several steps of different cellular pathways.

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PMC10887351

The beneficial effects of β3-ARs blockade on the immune system and tumor outcome could represent a new approach to treat cancer immune-editing, and it could be an efficient therapy for melanoma treatment.

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PMC11337594

A375 cells were treated with TER (2.0 µg/ml) to detect differences in the distribution of mitochondrial and intracytoplasmic proteins between the experimental and control groups (n = 3). (

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PMC11767817

It is well known that hypoxic conditions can alter cellular metabolism, promote a shift from oxidative phosphorylation to glycolysis , and reduce ROS generation .

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PMC10376064

One hemisphere was kept in paraformaldehyde (PFA 4% in PBS), the other on snap frozen in liquid nitrogen and later transferred to −80 °C (for protein extraction).

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PMC11502443

Interestingly, we observed the most pronounced biased agonism for tirzepatide.

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PMC10667689

Furthermore, since in vivo LSCs directly interact with bone marrow niche and cells and not only affect them but also are affected by them, co-culturing AML cells with bone-marrow-derived adipocytes and assessing the effect of TIM-3/Gal-9 interaction on leukemic cells and adipocytes can be a subject of interest.

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PMC8633974

Given that these were selected for their potential to recognize divergent HIV-1 quasispecies in patients and facilitate elimination from infected hosts , the comparative superiority of TatDE represents an advance in CRISPR therapy as a strategy for HIV-1 elimination.

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