OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	Image: Summary/Conclusion: This long term follow up data support the PET-CT adapted approach for all stages ofHL after a short course of ABVD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	With median duration of treatment of 55 days (range, 4~472), treatment-related adverse events (TRAEs) were reported in 17 patients (89.4%), most of which were grade 1 to 2 in severity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190538	Based on sensory assessments, the panelists deemed the flavour of yoghurts with C-phycocyanin concentrations of up to 300 mg satisfactory, especially when encapsulated with phytosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5810978	Before inoculation, cells were washed with cell specific serum-free medium twice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Before", "inoculation", ",", "cells", "were", "washed", "with", "cell", "specifi...
PMC10490530	Further, immunoblotting for p21 in the A2780 cell line treated with either doxorubicin alone or together with TNFα showed increased p21 expression, a downstream target gene of p53 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653168	Among acute leukemias, the incidence of ALL is five-times higher than that of acute myeloid leukemia (2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "acute", "leukemias"...
PMC9024365	Scale bar = 20 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "20", "μm", ".", "(" ] } ]
PMC11206502	OCR in pmol/min reveals the rate of decrease in oxygen in the assay medium and, as such, is a measure of mitochondrial respiration in the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655536	Na/H exchanger 1 (NHE1) is one of the SLC9 transporter family members which function to regulate intracellular pH (pHi) by exchanging an intracellular proton for an extracellular sodium ion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10933092	LncRNA transcripts with decreased mA sites after TRMT61A knockdown were significantly enriched in cellular processes, and protein domain-specific binding, as well as RNA, protein, and enzyme binding (Figure 5B and Supplementary Table S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	The data presented here therefore suggest that a variety of such domains could be successfully modeled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "presented", "here", "therefore", "sugge...
PMC10490530	During this study, we aimed to study the NF-κB, p53 macromolecules in PIK3CA gene regulation because of their significance in chemoresistant ovarian cancer and limited knowledge about their cross-talk .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	GSK3685032 binds to the DNA-protein interface of DNMT1, interfering with the interaction between DNMT1 and DNA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSK3685032", "binds", "to", "the", "DNA-protein",...
PMC11377827	Together, these data confirm that USP43 helps mediate the interaction between HIF-1α and 14-3-3ζ/ε, which in turn supports the chromatin localisation of HIF-1α and activation of HIF-1 target genes (Fig. 8).Figure 8USP43 mediated regulation of a HIF-1 transcriptional response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350	One of the most prominent PTCLs is angioimmunoblastic T cell lymphoma (AITL), which is a devastating disease, affecting mostly elderly patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8956657	IMPα2: MERS-CoV NLS was crystallized in 700 mM sodium citrate (pH 7.0) and 10 mM DTT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IMPα2", ":", "MERS-CoV", "NLS", ...
PMC9429973	The quantitative reverse transcription polymerase chain reaction (RT-PCR) was accomplished with the aim to determine the expression of the BCR-ABL p210 and p190 transcripts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11718109	After 3 days, pre-differentiated iNeurons were dispersed using Accutase and plated on 0.1 mg/ml poly-L-ornithine (Sigma-Aldrich) in borate buffer and 10 μg/ml laminin (Thermo Fisher Scientific) coated 35 mm glass-bottom dishes (MatTek) or 6-well plates (Corning) for imaging and immunoblotting, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: Explore the genetic landscape of SF3B1 mutated AML and determine the prognostic impact of SF3B1 mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Explore", "the", "genetic...
PMC6160470	Cells were washed with PBS twice and analysed by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "washed", "with", "PBS", "twice", "and", "analysed", "by", "flow", ...
PMC11194678	Scale bar, 2 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "2", "μm", ".", "(" ] } ]
PMC11640555	When BMEC cells were stimulated with LPS and then treated with CX-4945, the MTT assay revealed how LPS stimulates inflammation, reducing cell viability by up to 70%, while CX-4945 in a concentration-dependent manner (5, 10, and 15 μM) protected cells from LPS-induced damage (Figure 5D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597	D and E) MM1S cells were treated with bortezomib (1.25 nM) in combination with 6‐MP or daidzin for 48 h and cell apoptosis was determined using flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7136814	Doxorubicin elicited a similar effect, with an increase of the percentage of MYOD1+ NOG+ of 4.1 times (p < 0.001) and 16.6 times (p < 0.01) in RD and A-204, respectively (Figure 1(b), bottom panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11609529	Predictably, its encoded fusion protein consists of the N-terminal TEAD-binding domain (TBD) from YAP1 (aa 1–328) and the C-terminal transcriptional activation domain (TAD) from MAML2 (aa 172–1153).Figure 1Identification of YM fusion breakpoint and detection of endogenous YM fusion transcript and protein in ES-2 ovaria...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11248911	The selected compound was docked into the predetermined active site for the targeted proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "selected", "compound", "was", "docked", "into", "the", "p...
PMC11453346	Disclosure: G. Sakalauskaite: None.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Disclosure", ":", "G.", "Sakalauskaite", ":", "None", "." ] } ]
PMC10944868	Docking studies of colchicine and compound 12E.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Docking", "studies", "of", "colchicine", "and", "compound", "12E", "." ] } ]
PMC11019355	Having previously demonstrated the efficacy of the approach using human lymphoblastoid cell line GM12878, they apply it here to compare activity of 29,531 shared ATAC-accessible peaks between human and rhesus macaque.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	This was completed according to the known HXB2 reference strain (https://www.hiv.lanl.gov/content/sequence/HIV/MAP/landmark.html) from the Los Alamos National Library (LANL) HIV sequence database (https://www.hiv.lanl.gov/) using all 4004 complete sequences available through 2018.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11488203	These cells predominantly reside in perivascular regions of various organs and tissues and should be discriminated from fibroblasts or pericytes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cells", "predominan...
PMC10093184	Following a quick washing step in 3% acetic acid and distilled water, nuclear counterstaining was performed with nuclear fast red solution (Waldeck GmbH, Münster, Deutschland).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10734950	The data suggest potential selectivity in leukemia and lymphoma cell lines, with the CC50 being at or below 1 μM to the adherent cell lines whose CC50 is above 1 μM. In this study, we continued our experiments in the CCRF-CEM cell line to partially elucidate the mechanism of action of F8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803149	Epas1 might also promote infiltration of tumor-specific T cells into tumors, like Hif1a (50), since Epas1 controls expression of genes involved in tumor infiltration of immune cells, such as Plk4 and Tstd2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9599726	Cell lysates were centrifuged for 10 min at 13,000 rpm at 4 °C and each supernatant was transferred to a new tube.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", ...
PMC11420784	A, Western blotting of LC3-II levels in WT, ΔpldA, or ΔpldA+ infected 5637 cells at 4 hpi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "A", ",", "Western",...
PMC8633974	With a mutation rate of 1 in 1700 nucleotides , HIV-1 quasispecies easily accumulate during the course of viral infection .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "a", "mutation", ...
PMC9386809	The method has shown a high tolerance for sensitive functional groups, such as the chloro, hydroxyl, cyano, and nitro groups, present in the aromatic nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Vulnerability to treatment-related toxicities may also increase with age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vulnerability", "to", "treatment-related", "toxicities", "may", "also", "increase", "with", "age", "." ...
PMC9429973	All patients received DEC-C from Cycle 3 onwards until treatment discontinuation to assess safety and clinical efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "received", "DEC-C", "from", ...
PMC11588085	Stemness index of ovarian tumors with high (Upper quartile) vs. low XIST (Lower quartile) expression. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stemness", "index", "of", ...
PMC11201245	These can be very different and diverse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "can", "be", "very", "different", "and", "diverse", "." ] } ]
PMC11754784	FAM-labeled Nb-S was then released to bind CD47 on cell membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FAM-labeled", "Nb-S", "was", "then", "released", "to", "bind", "CD47", "on", "cell", ...
PMC11754436	During the in vitro experiment, the following groups were established: DHRS4-AS1 group, in which DHRS4-AS1 was overexpressed through lentiviral transfection; shDHRS4-AS1 group, in which DHRS4-AS1 was silenced through lentiviral transfection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267036	EMT plays a vital part in cancer development and progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EMT", "plays", "a", "vital", "part", "in", "cancer", "development", "and", "progression", ...
PMC4360730	Using the expected relationship as a guide, we investigate the branches starting at either the Uberon term or the selected ontology term, from CL or EFO and proceed across them to determine the missing relationship that would integrate the branches across ontology boundaries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678448	We further assessed the importance of these 51 genes using the betweenness centrality metric in the CytoNCA plugin (Figure 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "furthe...
PMC10914904	These findings collectively suggest that vtRNA 1-1 could exert a significant impact on therapies involving the activation of inflammatory components, leading to the inhibition of tumor cell proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8140214	First, 12×10 cells/well in a 96-well plate were incubated with 5.5, 30 and 50 mM D-glucose and/or 25 μM quercetin for 48 and 72 hr, respectively at 37ºC. Then, cells were incubated with MTT (0.5 mg/ml) dissolved in serum-free medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11578343	The line plots below each heatmap in (B) and (C) show the unit variance of elastic G′ and viscous G″, respectively, across the four zones measured for each single cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11564322	p < 0.001 vs. the respective peptide alone mRNA expression of KI67 and ELANE genes in the leukemia cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.001", "vs....
PMC11739484	Fig. 7This figure illustrates the miRNA-mRNA network construction analysis of MMP7, MMP11, and MMP14 genes in skin cutaneous melanoma (SKCM), conducted using the miRNet database and RT-qPCR assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411131	MeHg accumulates within the brain in the case of continuous ingestion of contaminated food.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MeHg", "accumulates", "within", "the", "brain", "in", "the", "ca...
PMC9429973	Instead, elderly patients are primarily treated with low-toxicity chemotherapy, originally, hypomethylating or low-dose cytotoxic agents and more recently, venetoclax in combination with hypomethylating agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	As expected, in ES2 cells, COL11A1 markedly increased the phosphorylation of Src and Akt (indicative of Src and Akt activation) as early as 2.5 h (Fig. S4A, C) which was retained even after 96 h of culture on COL11A1 (Fig. 2D, E).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10024132	Effector memory γ9δ2 T cells survive for at least 7 days in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effector", "memory", "γ9δ2", "T", "cells", "survive", "for", "at", "l...
PMC9429973	Clin.	[ { "tags": [ "O", "O" ], "tokens": [ "Clin", "." ] } ]
PMC10870498	The SuccinSite and GPSuc databases (http://systbio.cau.edu.cn/SuccinSite/; http://kurata14.bio.kyutech.ac.jp/GPSuc/index.php) were used to screen succinylation sites of KIF23.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "SuccinSite", "and", "GPSuc", "d...
PMC11363012	Although single-cell sequencing is now widely used in plants, rigorous structural characterization and quantification of metabolites in single cells have proven to be challenging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11705067	For DLAT gene, cg00327185 (HR:0.555, 95%CI: 0.34-0.905, P = 0.018) and cg13372927 (HR:0.498, 95%CI: 0.328-0.756, P = 0.0011) revealed a good prognosis in ccRCC patients, but cg10616121 (HR:2.442, 95%CI: 1.647-3.623, P < 0.001) and cg27191019 (HR:3.243, 95%CI: 1.774-5.929, P < 0.001) were associated with adverse patient...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7840816	Expression of SOX9 in human papillary thyroid cancer tissue specimens and cell lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "SOX9", "in", "human", "papillary", "thyroid", ...
PMC10125312	All three cell lines had lower viabilities at 24 h after irradiation than immediately after treatment (Figure 5A–C), although this decline of viability was only significant for 786-0 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	Chou-Talalay analysis was used for NPB (N) in combination with three PARP inhibitors, namely Olaparib (O), Rucaparib (R), and Talazoparib (T), in a panel of EOC cells including CAOV2 (BRCA-proficient/Platinum sensitive), A2780 (BRCA-proficient/Platinum sensitive), A2780cisR (BRCA- proficient /Platinum resistant) and AF...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	While infusion of expanded human T cells alone modestly delayed tumor growth, reflecting the baseline anti-tumor reactivity of the engrafted alloreactive T cells, treatment with LY3300054 significantly enhanced this effect resulting in potent anti-tumor activity (Fig. 5b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	Pearson’s correlation analysis highlighted a negative correlation between miR-494-3p and KIT mRNA expression in GISTs tissues (n = 20; r=-0.51, P = 0.02; Fig. 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10291556	Glucose consumption was normalized to final cell counts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glucose", "consumption", "was", "normalized", "to", "final", "cell", "counts", "." ] } ]
PMC11684821	These primed T cells were then enriched following exposure to WT melanoma line MM909.24 or MR1-KO MM909.24 overexpressing MR1*01 and expanded for 2 weeks prior to testing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	Up-regulated and down-regulated genes from miR-330 high samples were used to identify candidate drugs through the enrichr web tool, DSigDB, and literature searches .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11785489	This analysis is limited to TCRs found in more than one individual (“public TCRs”), which comprise <0.01% of the TCRs in this cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687663	This is the novel and most promising receptor for the development of anti-cancer agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "the", "novel", "and", "most", "promising", "recept...
PMC9429973	Methods: Our single-center study retrospectively revised and compared 155 apheresis process performed between July/2016 and October/2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Our", "single-center", "study", ...
PMC6114978	SJCRH30 cell line was treated with 0.125 μM trichostatin-A, SNF02.2 was treated with 0.25 μM trichostatin-A. HT1080, SKLMS1, and SW982 cell lines were treated with 1 μM 5-azacytidine.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", ...
PMC6461034	It is a highly connected, central node in the network.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "a", "highly", "connected", ",", "central", "node", "in", "the", "ne...
PMC10887351	The involvement of β-ARs signaling has been shown even in mouse models of prostate carcinomas , where the β-ARs antagonism blocked the improvement of tumor progression/metastasis induced by stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	T cells in blood and bone marrow were clearly distinct from lymph node derived cells, and several cell subsets showed a positively correlated abundance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11487720	The supernatants were added 1% SDS and RNase A (5 μg/μL) for incubation for 2 h at 56℃ and then treated with proteinase K (2.5 μg/μL) overnight at 37℃.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7917457	NTA was performed using a NanoSight NS300 (Malvern) at indicated time points with samples diluted to 1/500−1/2,000 with 0.9% sodium chloride.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11670407	P < 0.05, **P < 0.01 vs. the corresponding control OTULIN was required for high GPX4 expression in response to cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10565698	E. RNase R enzyme digestion to detect the stability of circUSP10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E.", "RNase", "R", "enzyme", "digestion", "to", "detect", "the", "stability", "of", ...
PMC9429973	Among pts with bariatric surgery, 61% required >1 TKI throughout the course of their disease due to intolerance or resistance, compared with 25% of the control group (P=0.002).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791203	No.LigandDocking score (Binding affinity, kcal/mol)BaxCaspase 9Caspase 3Cox-212,4-Ditert-Butylphenol− 6.4− 6.0− 6.0− 6.921,2-benzenedicarboxylic acid− 6.2− 6.1− 5.3− 6.53Cyclododecanol− 6.0− 5.4− 5.6− 6.04Sulfurous acid, hexyl octyl ester− 4.4− 3.8− 4.6− 5.0 Molecular docking data of the selected ligands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: Together, our data show that the HIF-1α/S1P axis mediates altered cytoskeletal reorganization and impaired PPF in ITP and suggest that ATRA correction of impaired PPF is a potential mechanistic explanation for the clinical efficacy of ATRA in ITP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7987994	There is no risk of cellular trauma as in the case of direct contact of the material with the cell layer and there is no risk of thermal shock as in the case of the agar diffusion method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705067	The relationship between DNA methylation and gene expression largely depends on the genomic location of DNA methylation, which also influences the clinicopathological features of cancers41, 42.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11252553	The controls contained only Taurine solvent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "controls", "contained", "only", "Taurine", "solvent", "." ] } ]
PMC9429973	At the time of presentation, 68% patients had a haemoglobin (Hb) level of less than 10g/dL and 43 % had severe thrombocytopenia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11297139	Bars represents the mean ± SEM; p < 0.01, *p < 0.001, NS non-significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bars", "repr...
PMC9429973	Depletion of SAMHD1 by VPX resulted in significantly lower levels of IFN-β and CXCL10 in cHL cells, which was linked to decreased NK cell killing of the cHL cells in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988808	B Overexpression efficiencies of CCDC25 in Caki-1 and 786–0 cells was detected by Western blot analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Overexpression", "efficiencies", "of", ...
PMC8592717	Dose-dependent PCA administration reduced multinucleated osteoclasts formation and tartrate-resistant acid phosphatase (TRAP) activity in RANKL-treated RAW264.7 murine macrophage cells through a decrease in the ROS and lipid peroxide levels and enhancement of the antioxidant status .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9412887	Nanomedicines larger than 150 nm mainly accumulate in spleen, liver and lungs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nanomedicines", "larger", "than", "150", "nm", "mainly", "accumulate", "in"...
PMC5535901	It consists of two subunits, p50 and p65, which, in the resting state, are held in the cytoplasm by the inhibitory κB (IκB) proteins .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	Moreover, a more recent advancement in the field of bioprinting called freeform reversible embedding of suspended hydrogels has been used for the development of tubular structures (both straight and branched) for instance compound bioink consisting of a mixture of alginate and decellularized porcine aortic tissue ECM b...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747885	Understanding the biological role of Rlig1 in this context is therefore crucial.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "the", "biological", "role", "of", "Rlig1", "in", "this", "conte...
PMC11518702	This points to further interactive effects of HGAL-GRB2 in this coalesced BCR context.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "points", "to", "further", "interactive", "effects", "of", "HGAL-GRB...
PMC11766332	Therefore, B4GALT1 emerged as a possible key regulatory gene node, which reinforces the link between glycosylation and ASD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "B4GALT1", ...
PMC5673060	Legend shows percentage of phosphosites that were up-regulated in DasR cells or A204 parental cells as well as phosphosites that displayed no change between the two cell lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	Brefeldin A (BFA) was used to block ER-to-Golgi trafficking, thereby inducing ER retention of MT-KIT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Brefeldin", "A", "(", "BFA", ")", ...
PMC9841531	However, the discovery is only the first of multiple steps to access these discovered targets for pharmacotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "discovery", "is...
PMC9874064	After incubation for 24 h, the Pt uptake in BEL-7404 cells treated with NP-Pt and NP-Pt-USP1i reached about 198 ng Pt/million cells and 196 ng Pt/million cells, respectively, approximately 2.6 times the amount of that in cells treated with cisplatin (about 76.62 ng Pt/million cells) (Fig. S7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Image: Summary/Conclusion: This long term follow up data support the PET-CT adapted approach for all stages ofHL after a short course of ABVD.

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PMC9429973

With median duration of treatment of 55 days (range, 4~472), treatment-related adverse events (TRAEs) were reported in 17 patients (89.4%), most of which were grade 1 to 2 in severity.

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PMC11190538

Based on sensory assessments, the panelists deemed the flavour of yoghurts with C-phycocyanin concentrations of up to 300 mg satisfactory, especially when encapsulated with phytosomes.

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PMC5810978

Before inoculation, cells were washed with cell specific serum-free medium twice.

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PMC10490530

Further, immunoblotting for p21 in the A2780 cell line treated with either doxorubicin alone or together with TNFα showed increased p21 expression, a downstream target gene of p53 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11653168

Among acute leukemias, the incidence of ALL is five-times higher than that of acute myeloid leukemia (2).

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PMC9024365

Scale bar = 20 μm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "20", "μm", ".", "(" ] } ]

PMC11206502

OCR in pmol/min reveals the rate of decrease in oxygen in the assay medium and, as such, is a measure of mitochondrial respiration in the cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11655536

Na/H exchanger 1 (NHE1) is one of the SLC9 transporter family members which function to regulate intracellular pH (pHi) by exchanging an intracellular proton for an extracellular sodium ion.

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PMC10933092

LncRNA transcripts with decreased mA sites after TRMT61A knockdown were significantly enriched in cellular processes, and protein domain-specific binding, as well as RNA, protein, and enzyme binding (Figure 5B and Supplementary Table S4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4443654

The data presented here therefore suggest that a variety of such domains could be successfully modeled.

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PMC10490530

During this study, we aimed to study the NF-κB, p53 macromolecules in PIK3CA gene regulation because of their significance in chemoresistant ovarian cancer and limited knowledge about their cross-talk .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11594074

GSK3685032 binds to the DNA-protein interface of DNMT1, interfering with the interaction between DNMT1 and DNA .

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PMC11377827

Together, these data confirm that USP43 helps mediate the interaction between HIF-1α and 14-3-3ζ/ε, which in turn supports the chromatin localisation of HIF-1α and activation of HIF-1 target genes (Fig. 8).Figure 8USP43 mediated regulation of a HIF-1 transcriptional response.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11401350

One of the most prominent PTCLs is angioimmunoblastic T cell lymphoma (AITL), which is a devastating disease, affecting mostly elderly patients .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC8956657

IMPα2: MERS-CoV NLS was crystallized in 700 mM sodium citrate (pH 7.0) and 10 mM DTT.

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PMC9429973

The quantitative reverse transcription polymerase chain reaction (RT-PCR) was accomplished with the aim to determine the expression of the BCR-ABL p210 and p190 transcripts.

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PMC11718109

After 3 days, pre-differentiated iNeurons were dispersed using Accutase and plated on 0.1 mg/ml poly-L-ornithine (Sigma-Aldrich) in borate buffer and 10 μg/ml laminin (Thermo Fisher Scientific) coated 35 mm glass-bottom dishes (MatTek) or 6-well plates (Corning) for imaging and immunoblotting, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Aims: Explore the genetic landscape of SF3B1 mutated AML and determine the prognostic impact of SF3B1 mutations.

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PMC6160470

Cells were washed with PBS twice and analysed by flow cytometry.

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PMC11194678

Scale bar, 2 μm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "2", "μm", ".", "(" ] } ]

PMC11640555

When BMEC cells were stimulated with LPS and then treated with CX-4945, the MTT assay revealed how LPS stimulates inflammation, reducing cell viability by up to 70%, while CX-4945 in a concentration-dependent manner (5, 10, and 15 μM) protected cells from LPS-induced damage (Figure 5D).

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PMC11789597

D and E) MM1S cells were treated with bortezomib (1.25 nM) in combination with 6‐MP or daidzin for 48 h and cell apoptosis was determined using flow cytometry.

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PMC7136814

Doxorubicin elicited a similar effect, with an increase of the percentage of MYOD1+ NOG+ of 4.1 times (p < 0.001) and 16.6 times (p < 0.01) in RD and A-204, respectively (Figure 1(b), bottom panel).

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PMC11609529

Predictably, its encoded fusion protein consists of the N-terminal TEAD-binding domain (TBD) from YAP1 (aa 1–328) and the C-terminal transcriptional activation domain (TAD) from MAML2 (aa 172–1153).Figure 1Identification of YM fusion breakpoint and detection of endogenous YM fusion transcript and protein in ES-2 ovaria...

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PMC11248911

The selected compound was docked into the predetermined active site for the targeted proteins.

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PMC11453346

Disclosure: G. Sakalauskaite: None.

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PMC10944868

Docking studies of colchicine and compound 12E.

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PMC11019355

Having previously demonstrated the efficacy of the approach using human lymphoblastoid cell line GM12878, they apply it here to compare activity of 29,531 shared ATAC-accessible peaks between human and rhesus macaque.

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PMC8633974

This was completed according to the known HXB2 reference strain (https://www.hiv.lanl.gov/content/sequence/HIV/MAP/landmark.html) from the Los Alamos National Library (LANL) HIV sequence database (https://www.hiv.lanl.gov/) using all 4004 complete sequences available through 2018.

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PMC11488203

These cells predominantly reside in perivascular regions of various organs and tissues and should be discriminated from fibroblasts or pericytes .

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PMC10093184

Following a quick washing step in 3% acetic acid and distilled water, nuclear counterstaining was performed with nuclear fast red solution (Waldeck GmbH, Münster, Deutschland).

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PMC10734950

The data suggest potential selectivity in leukemia and lymphoma cell lines, with the CC50 being at or below 1 μM to the adherent cell lines whose CC50 is above 1 μM. In this study, we continued our experiments in the CCRF-CEM cell line to partially elucidate the mechanism of action of F8.

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PMC11803149

Epas1 might also promote infiltration of tumor-specific T cells into tumors, like Hif1a (50), since Epas1 controls expression of genes involved in tumor infiltration of immune cells, such as Plk4 and Tstd2.

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PMC9599726

Cell lysates were centrifuged for 10 min at 13,000 rpm at 4 °C and each supernatant was transferred to a new tube.

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PMC11420784

A, Western blotting of LC3-II levels in WT, ΔpldA, or ΔpldA+ infected 5637 cells at 4 hpi.

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PMC8633974

With a mutation rate of 1 in 1700 nucleotides , HIV-1 quasispecies easily accumulate during the course of viral infection .

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PMC9386809

The method has shown a high tolerance for sensitive functional groups, such as the chloro, hydroxyl, cyano, and nitro groups, present in the aromatic nucleus.

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PMC9429973

Vulnerability to treatment-related toxicities may also increase with age.

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PMC9429973

All patients received DEC-C from Cycle 3 onwards until treatment discontinuation to assess safety and clinical efficacy.

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PMC11588085

Stemness index of ovarian tumors with high (Upper quartile) vs. low XIST (Lower quartile) expression. (

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PMC11201245

These can be very different and diverse.

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PMC11754784

FAM-labeled Nb-S was then released to bind CD47 on cell membrane.

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PMC11754436

During the in vitro experiment, the following groups were established: DHRS4-AS1 group, in which DHRS4-AS1 was overexpressed through lentiviral transfection; shDHRS4-AS1 group, in which DHRS4-AS1 was silenced through lentiviral transfection.

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PMC11267036

EMT plays a vital part in cancer development and progression.

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PMC4360730

Using the expected relationship as a guide, we investigate the branches starting at either the Uberon term or the selected ontology term, from CL or EFO and proceed across them to determine the missing relationship that would integrate the branches across ontology boundaries.

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PMC11678448

We further assessed the importance of these 51 genes using the betweenness centrality metric in the CytoNCA plugin (Figure 7A).

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PMC10914904

These findings collectively suggest that vtRNA 1-1 could exert a significant impact on therapies involving the activation of inflammatory components, leading to the inhibition of tumor cell proliferation.

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PMC8140214

First, 12×10 cells/well in a 96-well plate were incubated with 5.5, 30 and 50 mM D-glucose and/or 25 μM quercetin for 48 and 72 hr, respectively at 37ºC. Then, cells were incubated with MTT (0.5 mg/ml) dissolved in serum-free medium.

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PMC11578343

The line plots below each heatmap in (B) and (C) show the unit variance of elastic G′ and viscous G″, respectively, across the four zones measured for each single cell.

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PMC11564322

p < 0.001 vs. the respective peptide alone mRNA expression of KI67 and ELANE genes in the leukemia cell lines.

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PMC11739484

Fig. 7This figure illustrates the miRNA-mRNA network construction analysis of MMP7, MMP11, and MMP14 genes in skin cutaneous melanoma (SKCM), conducted using the miRNet database and RT-qPCR assay.

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PMC11411131

MeHg accumulates within the brain in the case of continuous ingestion of contaminated food.

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PMC9429973

Instead, elderly patients are primarily treated with low-toxicity chemotherapy, originally, hypomethylating or low-dose cytotoxic agents and more recently, venetoclax in combination with hypomethylating agents.

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PMC7171147

As expected, in ES2 cells, COL11A1 markedly increased the phosphorylation of Src and Akt (indicative of Src and Akt activation) as early as 2.5 h (Fig. S4A, C) which was retained even after 96 h of culture on COL11A1 (Fig. 2D, E).

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PMC10024132

Effector memory γ9δ2 T cells survive for at least 7 days in vivo.

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PMC9429973

Clin.

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PMC10870498

The SuccinSite and GPSuc databases (http://systbio.cau.edu.cn/SuccinSite/; http://kurata14.bio.kyutech.ac.jp/GPSuc/index.php) were used to screen succinylation sites of KIF23.

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PMC11363012

Although single-cell sequencing is now widely used in plants, rigorous structural characterization and quantification of metabolites in single cells have proven to be challenging.

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PMC11705067

For DLAT gene, cg00327185 (HR:0.555, 95%CI: 0.34-0.905, P = 0.018) and cg13372927 (HR:0.498, 95%CI: 0.328-0.756, P = 0.0011) revealed a good prognosis in ccRCC patients, but cg10616121 (HR:2.442, 95%CI: 1.647-3.623, P < 0.001) and cg27191019 (HR:3.243, 95%CI: 1.774-5.929, P < 0.001) were associated with adverse patient...

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PMC7840816

Expression of SOX9 in human papillary thyroid cancer tissue specimens and cell lines. (

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PMC10125312

All three cell lines had lower viabilities at 24 h after irradiation than immediately after treatment (Figure 5A–C), although this decline of viability was only significant for 786-0 cells.

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PMC9250505

Chou-Talalay analysis was used for NPB (N) in combination with three PARP inhibitors, namely Olaparib (O), Rucaparib (R), and Talazoparib (T), in a panel of EOC cells including CAOV2 (BRCA-proficient/Platinum sensitive), A2780 (BRCA-proficient/Platinum sensitive), A2780cisR (BRCA- proficient /Platinum resistant) and AF...

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PMC5925824

While infusion of expanded human T cells alone modestly delayed tumor growth, reflecting the baseline anti-tumor reactivity of the engrafted alloreactive T cells, treatment with LY3300054 significantly enhanced this effect resulting in potent anti-tumor activity (Fig. 5b).

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PMC11422497

Pearson’s correlation analysis highlighted a negative correlation between miR-494-3p and KIT mRNA expression in GISTs tissues (n = 20; r=-0.51, P = 0.02; Fig. 5E).

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PMC10291556

Glucose consumption was normalized to final cell counts.

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PMC11684821

These primed T cells were then enriched following exposure to WT melanoma line MM909.24 or MR1-KO MM909.24 overexpressing MR1*01 and expanded for 2 weeks prior to testing.

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PMC11806182

Up-regulated and down-regulated genes from miR-330 high samples were used to identify candidate drugs through the enrichr web tool, DSigDB, and literature searches .

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PMC11785489

This analysis is limited to TCRs found in more than one individual (“public TCRs”), which comprise <0.01% of the TCRs in this cohort.

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PMC11687663

This is the novel and most promising receptor for the development of anti-cancer agents.

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PMC9429973

Methods: Our single-center study retrospectively revised and compared 155 apheresis process performed between July/2016 and October/2021.

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PMC6114978

SJCRH30 cell line was treated with 0.125 μM trichostatin-A, SNF02.2 was treated with 0.25 μM trichostatin-A. HT1080, SKLMS1, and SW982 cell lines were treated with 1 μM 5-azacytidine.

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PMC6461034

It is a highly connected, central node in the network.

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PMC10887351

The involvement of β-ARs signaling has been shown even in mouse models of prostate carcinomas , where the β-ARs antagonism blocked the improvement of tumor progression/metastasis induced by stress.

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PMC9429973

T cells in blood and bone marrow were clearly distinct from lymph node derived cells, and several cell subsets showed a positively correlated abundance.

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PMC11487720

The supernatants were added 1% SDS and RNase A (5 μg/μL) for incubation for 2 h at 56℃ and then treated with proteinase K (2.5 μg/μL) overnight at 37℃.

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PMC7917457

NTA was performed using a NanoSight NS300 (Malvern) at indicated time points with samples diluted to 1/500−1/2,000 with 0.9% sodium chloride.

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PMC11670407

P < 0.05, **P < 0.01 vs. the corresponding control OTULIN was required for high GPX4 expression in response to cisplatin.

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PMC10565698

E. RNase R enzyme digestion to detect the stability of circUSP10.

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PMC9429973

Among pts with bariatric surgery, 61% required >1 TKI throughout the course of their disease due to intolerance or resistance, compared with 25% of the control group (P=0.002).

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PMC11791203

No.LigandDocking score (Binding affinity, kcal/mol)BaxCaspase 9Caspase 3Cox-212,4-Ditert-Butylphenol− 6.4− 6.0− 6.0− 6.921,2-benzenedicarboxylic acid− 6.2− 6.1− 5.3− 6.53Cyclododecanol− 6.0− 5.4− 5.6− 6.04Sulfurous acid, hexyl octyl ester− 4.4− 3.8− 4.6− 5.0 Molecular docking data of the selected ligands.

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PMC9429973

Summary/Conclusion: Together, our data show that the HIF-1α/S1P axis mediates altered cytoskeletal reorganization and impaired PPF in ITP and suggest that ATRA correction of impaired PPF is a potential mechanistic explanation for the clinical efficacy of ATRA in ITP.

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PMC7987994

There is no risk of cellular trauma as in the case of direct contact of the material with the cell layer and there is no risk of thermal shock as in the case of the agar diffusion method.

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PMC11705067

The relationship between DNA methylation and gene expression largely depends on the genomic location of DNA methylation, which also influences the clinicopathological features of cancers41, 42.

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PMC11252553

The controls contained only Taurine solvent.

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PMC9429973

At the time of presentation, 68% patients had a haemoglobin (Hb) level of less than 10g/dL and 43 % had severe thrombocytopenia.

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PMC11297139

Bars represents the mean ± SEM; **p < 0.01, ***p < 0.001, NS non-significant.

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PMC9429973

Depletion of SAMHD1 by VPX resulted in significantly lower levels of IFN-β and CXCL10 in cHL cells, which was linked to decreased NK cell killing of the cHL cells in vitro.

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PMC10988808

B Overexpression efficiencies of CCDC25 in Caki-1 and 786–0 cells was detected by Western blot analysis.

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PMC8592717

Dose-dependent PCA administration reduced multinucleated osteoclasts formation and tartrate-resistant acid phosphatase (TRAP) activity in RANKL-treated RAW264.7 murine macrophage cells through a decrease in the ROS and lipid peroxide levels and enhancement of the antioxidant status .

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PMC9412887

Nanomedicines larger than 150 nm mainly accumulate in spleen, liver and lungs.

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PMC5535901

It consists of two subunits, p50 and p65, which, in the resting state, are held in the cytoplasm by the inhibitory κB (IκB) proteins .

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PMC8557138

Moreover, a more recent advancement in the field of bioprinting called freeform reversible embedding of suspended hydrogels has been used for the development of tubular structures (both straight and branched) for instance compound bioink consisting of a mixture of alginate and decellularized porcine aortic tissue ECM b...

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PMC11747885

Understanding the biological role of Rlig1 in this context is therefore crucial.

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PMC11518702

This points to further interactive effects of HGAL-GRB2 in this coalesced BCR context.

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PMC11766332

Therefore, B4GALT1 emerged as a possible key regulatory gene node, which reinforces the link between glycosylation and ASD.

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PMC5673060

Legend shows percentage of phosphosites that were up-regulated in DasR cells or A204 parental cells as well as phosphosites that displayed no change between the two cell lines. (

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PMC10589262

Brefeldin A (BFA) was used to block ER-to-Golgi trafficking, thereby inducing ER retention of MT-KIT.

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PMC9841531

However, the discovery is only the first of multiple steps to access these discovered targets for pharmacotherapy.

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PMC9874064

After incubation for 24 h, the Pt uptake in BEL-7404 cells treated with NP-Pt and NP-Pt-USP1i reached about 198 ng Pt/million cells and 196 ng Pt/million cells, respectively, approximately 2.6 times the amount of that in cells treated with cisplatin (about 76.62 ng Pt/million cells) (Fig. S7A).

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