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OTAR3088
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PMC11635087
Adherent CHO-K1 cells (RCB0285) were cultured in Ham’s F12 (Wako, Cat.
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PMC11791432
Qianxing Hu: Visualization, Validation, Supervision, Software, Conceptualization.
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PMC11122631
Octocoral of the genus Clavularia is a kind of marine invertebrate possessing abundant cytotoxic secondary metabolites, such as prostanoids and dolabellanes.
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PMC9952933
The current results indicate a discrete reduction in cell motility; however, no differences were found between malignant and non-malignant bone cells.
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PMC11441402
In brief, adherent cells were fixed with 50% (w/v) ice-cold trichloroacetic acid (TCA, Sigma-Aldrich, Merck, Germany) for 1 h at 4 °C.
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PMC11476106
It can influence tumor behavior and aggressiveness due to the remarkable adaptability of tumor cells and intratumor heterogeneity .
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PMC11531744
We could see from the heat-map that the high-risk genes were TNFAIP8L3, PI3, TMEM181, KIF26B, CACNA1C, PYGB, STAC2 and FAM120B. (
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PMC4443654
We found open and closed compartments to be well correlated with combinatorial patterns of histone modifications and DNA binding proteins, enabling accurate predictive models.
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PMC11768927
For instance, Hwang et al. demonstrated that HIF-1α overexpression in renal clear-cell carcinoma and glioblastoma models conferred increased resistance to VSV infection.
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PMC7961460
Moreover, the degradation of HA by HYALs of tumour cells, forms fragments of low molecular weight HA, which, in turn, modify the ECM and eventually accelerate the tumour neovascularisation and enhances metastasis.
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PMC9436459
M. alba, M. mongolica, M. macroura, M. bombycis, M. australis, M. lhou, M. wittiorum, and S. bonplandii are rich in MDAAs (Table 2).
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PMC11122631
The specimens of Clavularia spp.
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PMC10033453
Overall, we show that VMG exhibits multi-modal efficacy by induction of oncolysis in multiple sarcoma subtypes, as well as stimulating significant CD8+ T cell infiltration in a syngeneic model of fibrosarcoma.
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PMC9370419
Second, the media were changed, and the drugs were added at a final concentration of 10 µM without Dox.
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PMC11566417
CM from both cell lines at p10 significantly increased the number of endothelial branches and meshes when compared to the DMEM control (Fig. 4c(i) and (ii)).
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PMC11696576
A direct regulation of epigenetic modifiers by cPLA2α signaling has to our knowledge not been described to date.
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PMC11766174
In addition, the efficacy of TACK treatment, assessed by HIV viral genomic RNA quantification using qPCR, was comparable to that assessed by CA-ICC (Figure 5D).
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PMC11063646
Spreadability values above 7.5 g cm/sec show good spreadability properties (Mwangi et al., 2021).
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PMC11483468
The TAT-LPTS39 polypeptide without the GST tag similarly inhibited the growth of telomerase-positive cancer cells Hela and PLC-PRF-5 in vitro, BEL-7404 CDX tumour in vivo and shortened telomere length.
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PMC11653168
This might suggest that T-ALL cells are more resistant to immediate STAT3 inactivation but become vulnerable with prolonged Stattic exposure, which could be therapeutically relevant.
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PMC11301095
In light of the current diagnostic and therapeutic landscape, the rapid progression and high mortality rate of PAM necessitate heightened vigilance among physicians, particularly when dealing with vulnerable groups such as children.
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PMC9532503
Fig. 4SPR sensorgrams obtained for FcγRIIIa V158 (A, B) and F158 (C, D) receptors for the test anti-CD20 antibody (P2-CRD-1508) (B, D) and control antibody (RS-03-25) (A, C).
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PMC10213199
Subsequently, the total RNA was quantified using a Nano Drop and Agilent 2100 bioanalyzer (Thermo Fisher Scientific, MA, USA).
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PMC11617590
Statistical significance was based on the difference compared with 0 μM SFN by two‐way ANOVA, followed by the Bonferroni test (n = 3) (**p < 0.01, ***p < 0.001).
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PMC11078693
Check that the labeled side (e.g., side with letter R) is facing up.f.
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PMC11509278
Among the positive ion metabolites (Figure 3A,B), organic acids and their derivatives accounted for 27.15%, and lipids and lipid-like molecules accounted for 26.08%.
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PMC11794847
Quantitative PCR and Western blotting determined gene and protein expression, respectively, cellular respiration was measured through oxygen consumption rate (OCR) assays.
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PMC11788920
To attain a more complete picture of dCas9-mediated regulation in c-Myc transcription, we performed a systematic cellular study in Burkitt’s Lymphoma Ramos cell line.
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PMC11566417
Methicillin-resistant S. aureus (MRSA) is one common pathogen that evades conventional antibiotic treatments and the host immune response across species, leading to substantial tissue damage [105–108].
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PMC11731161
A Coomassie blue staining of SDS gel loaded with proteins immunoprecipitated using anti-XPO1 antibodies from DMSO treated or 500 nM SEL treated NCI-H929 cells.
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PMC11513011
We investigated the association between DIB administration and FoxM1 expression by western blot.
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PMC9429973
We established an escape-simulation model to explore whether the compound CAR-T could reduce the risk of relapse associated with antigen loss.
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PMC11389534
Increased interaction between 14‐3‐3ε and UFL1 leads to UFMylation and subsequent binding to K63‐ubiquitinated RIG‐Ι, enhancing downstream IFN signalling during SenV infection.
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PMC11307990
The mixed solution was annealed according to the following annealing program: 95 °C for 5 min, 85 to 65 °C for 1 h, and then slow cooling from 65 to 25 °C during a period of 8 h. The annealed solution was centrifuged using a 100 kDa MWCO ultrafiltration tube at a speed of 3000g for 15 min, and this process was repeated...
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PMC9429973
Aims: Evaluate the overall response rate (ORR) at 6 and 12 months and the adverse eventes (AEs) of ruxolitinib used as salvage therapy for cGvHD.
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PMC11676674
Concentrations exceeding 200 µg/mL were found to be toxic against CHOK1 cells, with cytotoxicity levels of more than 50%.
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PMC11055510
Colony formation assay analyzed the effect of si-circMAN1A2 interaction with miR-135a-3p inhibitor on the ability of a cell to form clones in A2780 cells. (
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PMC11473750
In cancer cells, RING Finger proteins may behave as oncogenes or tumour suppressors dependent on the context and it is unclear which structural features determine these functions.
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PMC10165258
Nevertheless dying cells may secrete by-products that may influence their neighbors and this effect may be more pronounced in the small droplets.
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PMC6034753
Homo/hetero dimerization of Meq and multimerization of apoptin are important characteristics that are associated with the biological functions of these proteins , possibly by providing additional interface (s) for binding proteins.
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PMC11802929
c The top differential TCR physicochemical properties for effector (Cytotoxic, EM and Hybrid) phenotypes, relative to non-effector (CM and naïve) phenotypes.
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PMC9164404
Notably, the main differential lipids were glycerophospholipids (LPC, LPE, PC, and PG) and a very small amount of sphingolipids (SM, LSM) in the cells treated with Abplatin compared with PBS.
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PMC7823217
This review clearly outlines current challenges and prospects for 3D bioprinting technologies in cancer research by focusing on the clinical application of these technologies for chemotherapeutic drug screening and the development of personalized treatment regimens for cancer patients.
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PMC11679033
To establish the relative number of cell cycles per cell during the period of exposure to cytoB in treated compared to control cultures, the Replication Index (RI) was also calculated according to the formula:RI = × 100 Finally, from the obtained values of RI, the cytotoxicity estimate was deduced, as % Cytotoxicity = ...
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PMC10197932
Furthermore MOLM-13 cell line cannot proliferate after 2 treatments (2T) of US (data not shown).
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PMC11397654
The mechanism of the drug delivery is based on the folic acid conjugated with a pyridinium group, which targets the cancer cells by binding to the folate receptors on their surface, allowing the nanoplatforms to accumulate in the tumour tissue.
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PMC7642379
Two examples are 293T and 293E cell lines, constitutively expressing the temperature sensitive allele of the large T antigen of Simian virus 40, or the Epstein-Barr virus nuclear antigen EBNA1, respectively.
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PMC11641532
Furthermore, in vitro and in vivo functional studies demonstrated that HSD3B7 overexpression enhances cell proliferation, migration, and invasion, while its silencing suppresses these oncogenic properties.
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PMC11473843
To further test this hypothesis, we assessed the effect of pharmacological inhibition of ERK5 (XMD8-92) (Yang et al, 2010) and CDK5 (Seliciclib) (Cicenas et al, 2015) in a panel of NSCLC cancer cells (A549, A427 and H460) bearing mutKRAS.
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PMC9429973
For pts with ND Ph+ ALL, SCT does not appear to be needed in first remission.
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PMC11225860
Combination therapy resembled a relatively normal cell cycle with an increased G1 population until the expected second round of division at 36 hours.
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PMC7305184
If the adaptive resistance would be obtained in vitro further in vivo experiments would be necessary.
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PMC11699042
Euclidean distances (ED) between drug sensitivity profiles of each strain were calculated using the following formula: function(x1, x2) sqrt(sum((x1 – x2))) = ED, where x1 is the mean value of AUC of all strains and x2 the AUC of individual cell lines.
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PMC11468365
The drug features are extracted from 2041 selected genes by drug-target interaction and cell line features are extracted from the 2041 gene dependency or gene expression.
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PMC11535726
Sexual morph: see Hawksworth (1985).
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PMC9895440
Badour and colleagues described that SNX9 amplifies CD28 signaling by increasing its internalization.
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PMC9429973
The number of clonally reduced reads for a given pMHC specificity was used to estimate the frequency of T cells specific for a given epitope, based on the average number of T cell receptor–MHC multimer interactions detected in the total MHC multimer-binding T cell pool in a given cell sample.
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PMC5034105
The highest mean viral loads (⩾10 lgcopies/mL) were observed in the placental (JEG-3), cervical (HeLa), neuronal (SF268), upper respiratory tract (Hep-2) and intestinal (Caco-2) cell lines.
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PMC11345828
H NMR (400 MHz, CDCl3) δ 9.18 (s, 1H), 7.80 (d, J = 8.8 Hz, 1H), 7.49 (s, 0.3H), 7.48 (s, 0.7H), 7.34 (d, J = 8.8 Hz, 1H), 6.93–6.92 (M, 1H), 6.61 (s, 1.3H), 6.60 (s, 0.7H), 4.39 (d, J = 8.4 Hz, 0.3H), 4.30–4.23 (m, 1H), 4.17 (dd, J = 13.2, 3.6 Hz, 0.7H), 4.11 (s, 1H), 4.06 (s, 2H), 4.04 (s, 1H), 4.03–3.95 (m, 6H), 3.9...
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PMC10578720
Next, we used label-free mass spectrometry to quantify the glucose metabolites in human THP-1 macrophages following exposure to different HBV titers (0, 10, 10 IU/mL).
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PMC11658074
a The protein expression of CD151 in AT-EVs and ADSC-EVs.
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PMC10899471
The animal study was approved by Animal Welfare and Ethics Committee of Army Medical University.
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PMC7504302
Furthermore, CDK7 (cyclin-dependent kinase 7), a serine/threonine protein kinase, can sustain Hippo signaling by directly phosphorylating and protecting YAP from ubiquitination and degradation .
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PMC9429973
AUROC values were 0.76 and 0.72.
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PMC9712534
Representative images of FRAP analysis of EGFP-TOP2B H58Y.
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PMC11098378
Therefore, experimental strategies to study effector functions outside of bacterial infections may be useful for determining their role during natural infection.
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PMC10380508
FPKM values were transformed into transcripts per kilobase million (TPM) values.
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PMC11332076
Binding of insulin to its extracellular domain activates the kinase domain in the intracellular region of the receptor, leading to the activation of Ras-ERK and PI3K-AKT signaling pathways.
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PMC11486946
Source data are provided as a Source Data file.
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PMC11741577
The following program was performed twice: 30 s at 94°C (denaturation), 30 s at 62°C (annealing), and 30 s at 72°C (extension) for 35 cycles.
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PMC11411131
Mouse cerebellar granule cells (CGCs) were transfected with Krab-Sec/Luc using calcium phosphate precipitation.
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PMC9646302
no. C0071S; Beyotime Institute of Biotechnology, Shanghai, China).
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PMC11543935
A temperature offset was determined from a water bottle positioned at the edge of the FoV. The AlamarBlue assay was performed following the standardized manufacturer protocol (Thermo Fisher Scientific Inc., United States, DAL1025).
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PMC11755467
Inhibition of hsa-miR-122 using the anti-miRNA oligonucleotide inhibitor miravirsen leads to repression of HCV virus load in HCV patients .
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PMC11789597
mRNA expression of CAV1 in MM cells transduced with lentivirus expressing shRNAs against NC (LV‐shNC) or CAV1 (LV‐shCAV1) was determined using qRT‐PCR.
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PMC11674146
E, F) Expression levels of BAX (E) and Caspase-3 (F) in CLP36-silencing lymphoma cells BJAB and RA 1, quantified via qPCR.
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PMC11279397
Studies have demonstrated that germacron activated transcription of interferon genes and protects peripheral cells from IAV infection .
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PMC10926885
Using the TISIDB portal, the link between NDE1 expression level and cancer immune subtypes and molecular subtypes was examined.
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PMC11352746
Importantly, the reproducibility crisis in scientific research has been highlighted extensively over the past 20 years, and this issue is a chief concern for the use of AI in drug discovery.
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PMC11791203
Moreover, Gutierrez-Silerio et al. analysed the cytotoxic effects of methanolic extracts from avocado fruit mesocarp on HT29 cells, with the strongest effect associated with chlorogenic acid.
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PMC10178190
Cytokine Array: The human XL cytokine array kit (R&D Systems, Minneapolis, MN, USA) was utilized to detect relative levels of various cytokines, chemokines, growth factors, and adipokines.
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PMC11680049
For this, a sample of 1 g of plant material was extracted with 10 mL of 96% ethanol for 1 h at a temperature of 37 ± 1 °C, filtered through a paper filter (blue stripe), evaporated to dryness, and weighed to determine the exact mass.
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PMC9516447
The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regulator of the unfolded protein response (UPR).
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PMC9429973
However, the EORTC QLQ-MY20 body image showed clinically meaningful improvement from baseline (Table).
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PMC11188874
Gating of these pores is controlled by regulatory particles (RP), for example, PA28αβ (11S RP), PA28γ, PA200, and the 19S RP (PA700; ref.
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PMC9429973
No gastric lymphomas relapsed.
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PMC11574029
Currently, Antibody-drug conjugates (ADCs) such as Enfortumab Vedotin targeting Nectin-4, Disitamab Vedotin targeting HER2, have shown promising effect in the treatment of solid tumors, including BLCA .
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PMC9429973
Transfusions at a higher level (given the absence of research evidence, as determined by clinical circumstances, generally at threshold of 40x109 /L) may be required for patients with signs of bleeding, high fever, hyper-leukocytosis, rapid fall in platelet count, concomitant coagulation abnormality, critically ill pat...
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PMC11361748
We next tested whether the amplification of neutrophil infiltration represents a stably acquired property in TPA-Tx skin.
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PMC6771295
Representative western blot is shown.
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PMC9516401
Cell cultures The human colorectal adenocarcinoma cell line Caco-2 (NCBI code C139) was purchased from the National Cell Bank of Iran (NCBI), Pasteur Institute (Tehran, Iran) and cultured in 50% RPMI 1640+35% DMEM High Glucose with 10% FBS and antibiotics (100 μg/ml streptomycin and 100 U/ml penicillin) (Farsani et al....
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PMC10994876
4YAP5SA-induced cell growth and viability in CHO cells using the a Trypan blue and b MTS assays.
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PMC5811757
For this purpose, RNA samples were mixed with distilled water, buffer as well as DNase I and were incubated at 37°C for 30 min.
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PMC11590870
Other amino acids important in peptides with anticancer activity are proline, histidine, and tryptophan.
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PMC7642379
Green bar shows 329 common DE genes in pairwise comparisons of progeny with HEK293 parental cells.
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PMC10808409
The downregulation of matrix metalloproteinase-9 (MMP-9) was a contributing factor in the metastatic action of P123 in both in-vitro and in-vivo.
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PMC9509578
Rapid metabolism of anticancer drugs and detoxification of drugs by cytochrome P450 are associated with rapid turnover and elimination of anticancer drugs .
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PMC9429973
According to AGR, median overall survival was 6.8 months on favorable and 1.2 month on adverse risk group (p=0.012).
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PMC11527437
Notably, this therapy can mediate durable clinical responses in some patients with metastatic melanoma (3–5), which led to its approval by the FDA for this indication in February 2024.
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PMC11438317
In this work, we show that LYP can dephosphorylate directly SLP76 in the C-terminal tyrosine 128.
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