OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11371747	In fact, treatment with either a conventional bolus of 5FU or with a continuous infusion (either 1 week or longer) can induce the expression of TS up to 3-5-fold (Peters et al., 1993; Codacci-Pisanelli et al., 1995).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	These experiments are consistent with studies on epithelial cells, in which cell respiration was blocked immediately after the addition of plasma-activated medium (PAM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11317131	During IntePACE, host cells harboring both the AP and CP are continuously added to a fixed volume vessel called the ‘lagoon’.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	These results aim to help clinicians in optimizing treatment approaches for patients with MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "aim", "to", "help", "clinicians", "in", "opt...
PMC9119314	In addition, new antimalarials should be affordable and available to those who need them most, and it may also be argued that in the context of climate change/global warming, it is important that their production should not be environmentally damaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	However, these experiments were performed at non-physiological pH, ion concentrations, and temperatures that may have stabilized the activated particles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC11775197	First, the question of how PPAR affects the growth and progression of CRC through the TME is not well understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "the...
PMC8751435	a, b) Graphic representation of cell cycle distribution, data points are the percentage of cells in G0, G1, S, and G2/M at 24 h after treatment. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Currently she is without critical stenosis or cerebrovascular events, maintaining only imaging follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", "she", "is", "without", "critical", "stenosis", "or", ...
PMC11481779	In the case of the current models, like the aforementioned C.Origami or Akita, the model output is blurred.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "case", "o...
PMC3931643	Therefore, 4EBP1 loss might occur in a fraction of primary human DLBCL tumors as observed in the VAL cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", ...
PMC10452486	Some HLA-I polyreactive mAbs (MEM series) used for immunostaining confirm the existence of B2m-free variants in several cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "HLA-I", "...
PMC11021472	A monoclonal cell line (miR-150BSdel) was generated using CRISPR/Cas9 technology with two guide RNAs flanking the miR-150 binding site region in ZDHHC11 (Supplemental Fig. 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	Five to ten days post-infection, cell lines were evaluated for gene editing, i.e., BCAT1 silencing or overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Five", "to", "ten", "d...
PMC11740508	A12621, Invitrogen®), according to manufacturer protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A12621", ",", "Invitrogen", "®", ")", ",", "according", "to", "manufacturer", "protocol", ...
PMC11536589	These results showed that PKF-118-310 has the ability to repress the MGST1 expression and induce ferroptosis in MRTX1133-resistant PDAC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "These", ...
PMC9429973	All patients started a 14-day run-in of HCQ at their intended HCQ dose level (DL) before the first cycle of HCQ-Kd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", ...
PMC11779605	Further study of these specific differentially expressed genes and pathways has the potential to identify biomarkers of metastases and drug targets for inhibiting metastases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10568263	10 μL of anti-HSP70 was added dropwise on the surface of EN-LC/Au@MnO2/MoO3/SPEs and incubated at 37 °C for 1 h. The unbound anti-HSP70 on the electrode surface was washed with DI water and dried at 37 °C for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	Due to the high expression level of SMPDL3B, we selected the SK-OV-3 and HEY cell lines for subsequent functional experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", ...
PMC8068766	The p-value threshold was taken as 0.01 while selecting the DEG lists.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "p-value", "threshold", "was", "taken", "as", "0.01", "while", "selecting"...
PMC9878278	Similar to what we observed with RIG-I silencing, MDA5 silencing also led to a significant increase (~200%) in ZIKV titers as compared to siCtrl cells only at 48 and 120 hpi (Figure 4C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	was often used for treating arthritis in the Far East: OAH19T (10, 20, 40 μg/mL) protected chondrocytes through down-regulating the levels of MMP-1, MMP-3, aggrecanase-1, aggrecanase-2 and promoting cell proliferation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11587606	These experiments were repeated two times under identical conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "experiments", "were", "repeated", "two", "times", "under", "identical", "conditions", "." ] ...
PMC6268318	= intraperitoneal; p.o.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "=", "intraperitoneal", ";", "p.o", "." ] } ]
PMC10926885	C1 (wound healing); C2 (IFN‐gamma dominant); C3 (inflammatory); C4 (lymphocyte depleted); C5 (immunologically quiet); C6 (TGF‐b dominant).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365983	A–C) Foxc1 shRNA inhibition significantly reduced the level of total Pdgfrα, and auto-phosphorylated pY754-Pdgfrα in serum-starved NIH3T3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", ...
PMC11632064	Gene functional analysis (g:Profiler; Reactome) of additional significantly up-regulated transcripts, related to Fig 2B and C. (B) Gene functional analysis (g:Profiler; Reactome) of additional significantly down-regulated transcripts, related to Fig 2B and D. (C) Top gene set enrichments identified by GSEA (Hallmarks, ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10914904	In particular, the integration of the small fragment derived from vtRNA1-2, which was designated svtRNA1-2, was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC2614415	Three independent biological replicates were performed, luminescence measured and data analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "independent", "biological", "replicates", "were", "performed", ",", "luminesc...
PMC10606998	Unlike protons, photon irradiation transmits energy all the way through the patient’s body, increasing initially and decreasing exponentially as photons are absorbed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11472569	ABC transporters are a family of membrane proteins that utilize ATP hydrolysis to transport a diverse array of substrates, including ions and macromolecules, across extra- and intercellular membranes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Furthermore, copper chelation treatment caused neutrophils to supersede tumor cells when comparing incoming interaction strengths, alluding to the dampening of tumoral-induced immunosuppression (Fig. 5c; Supp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	Electron micrographs were recorded in the counting mode of the detector at a magnification of 105,000×, which corresponds to a pixel size of 1.34 Å. Total electron exposure was 50 e / Å, and defocus values ranged from −1.8 to −3.0 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8068766	With this aim, the results of an Affymetrix expression array were analyzed and the DEG lists were identified using limma analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "this...
PMC11075223	In order to better apply to the clinic, the study on the differences between raw and processed products should be further deepened.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11783017	In the osteosarcoma-bearing model, the nanocomposite hydrogel significantly enhanced tumor T cell infiltration, induced effective anti-tumor immunity and attenuated lung metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9621239	Additionally, to confirm the difference in the evolution of the HBV X gene between intra-patient tumour and non-tumour tissues, the phylogenetic analysis for the haplotypes of the HBV X gene in the liver tissue of each patient with HCC was performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7090062	Nevertheless, combining autophagy inhibitors with first-line therapies has succeeded in overcoming resistance or increasing sensitivity to the front-line drugs in clinical hematopoietic disorders, including several types of leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7081114	Cumulative survival was compared using the Kaplan–Meier method with the log-rank test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cumulative", "survival", "was", "compared", "using", "the", "Kaplan", ...
PMC11745600	Their body weight, nonfasting blood glucose, and survival were measured from 4 wk of age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "body", "weight", ",", "nonfasting", ...
PMC11734514	Bar graph showing protein expression of (B) PTEN, (C)AKT, (D) p-AKT, (E) p-mTOR, and (F) STAT-3 obtained through Western blotting in A549 cells treated with C. aerizusa extract.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700247	Working model: time line and schematic representation of in vivo A20 tumor–bearing mice treated with RT followed by CART-19 cell injection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC7334607	Experimental time points (x axis) represent which step in the drug cycle the replicates have just recovered from.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experimental", "time", "poin...
PMC6222635	The morphology changes in HeLa cells after treatment with F1 and F3 at a concentration of 400 μg/mL for 24 and 48 h was observed.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC9429973	As shown in Fig K, EBV+ B cells exhibited a wider and more distribution in RR-AITL (Fig L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in...
PMC9429973	The booster dose increased SARS-CoV-2 spike-specific T cells in both MMD and MMR reaching the 100% of responder patients with an increased percentage of IL-2+CD4+ T cells compared to full vaccination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794588	Its oxidative stress-inducing properties align with its role in liver cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "oxidative", "stress-inducing", "properties", "align", "with", "its", "role", ...
PMC11568601	There have been many attempts to target ER stress-associated proteins, including IRE1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "have", "been", "many", "attempts", "to", "target", "ER", "st...
PMC7305184	In this test the sensitive parental cells are compared to the surviving daughter resistant cells by viability assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "test", "the", "sensitive...
PMC10170482	We used the human hepatoblastoma HepG2 cell line (American Type Culture Collection, ATCC, Manassas, VA, USA) and human hepatocellular carcinoma cell line Alexander (PLC/PRF/5, ATCC, Manassas, VA, USA) in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11344246	In total this gave us 820 edges involving 659 vertices (unique human proteins).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "total", "this", "gave", "us", "820", "edges", "...
PMC11359735	Metabolic labeling of P. berghei sporozoites with [H]-palmitic acid and [H]-ethanolamine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metabolic", "labeling", "of", "P.", "berghei", "sporozoites", "with", "[H]-palmitic", "acid...
PMC11706297	In an attempt to find effective, selective, and targeted anticancer agents, we synthesized new naphthalene-linked pyrazoline–thiazole hybrids and screened their anticancer activity against A549 and MCF-7 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	ASCT was performed in only 4 cases (3 after RC1 and 1 after relapse).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ASCT", "was", "performed", "in", "only", "4", "c...
PMC11763111	Deleting class I of human leukocyte antigen (HLA-I) and class II of human leukocyte antigen (HLA-II) can prevent rejection by allogeneic T cells; however, natural killer (NK) cell rejection due to the loss of self-recognition remains unresolved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Data were further processed using Skyline v22.2.0.255.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "further", "processed", "using", "Skyline", "v22.2.0.255", "." ] } ]
PMC10093184	Analysis revealed that the genetic background of COS3600/COS3600B, COS4074, and COS4288 cell lines came from three different animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "reve...
PMC11297139	Scale bar: 5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "5", "μm", "." ] } ]
PMC11023271	We examined the protein contents of fractions from the 100KD filters on SDS-PAGE and found that the predominant protein band in the >100K fraction corresponded to bovine serum albumin (BSA) (Fig 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	a Real-time PCR of FASN in A2780cis-scrambled and A2780cis-shCOL11A1 and in ES2 cells co-cultured with CAF-scrambled or CAF-shCOL11A1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Real-time", "PCR",...
PMC11680562	Subsequently, a 10 mL solution of 0.2 M Cu(NO3)2 3H₂O was gradually added dropwise to the extract.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "a", "10", "mL", ...
PMC9429973	Due to the selectivity to asparagine depletion, we then investigated whether SOD2 inhibition mediates a broader amino acid starvation response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "the"...
PMC10213179	The ATOP aptamer or the SCR control aptamer were incubated on cells for 1 h and the internalized aptamer RNA recovered after a stringent high-salt wash (0.5M NaCl) was assessed by qRT-PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694066	Cisplatin was used as the positive control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cisplatin", "was", "used", "as", "the", "positive", "control", "." ] } ]
PMC11024707	To the best of our knowledge, there is no study comparing the individuals diagnosed with ASD to their non-diagnosed siblings In this study, mi-RNAs that were consistently shown to be associated with ASD in the previous research, –are thought to be closely associated with ASD pathogenesis– were investigated and it is as...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745600	The C96Y mutation in Ins2 reported in Akita mice, which is inherited as an autosomal dominant trait, is known to cause hyperglycemia and severe diabetes in homozygous and heterozygous mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6642070	We scanned the ENO3 promoter (−2000 to +100) and found 3 putative p53RRE sites with >90% identity (Fig. 5a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Its overexpression restores cell proliferation control by stabilizing p53 activity, and DNA damage repair by rescuing the H3K36me3 mark.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "overexpression", "res...
PMC11754432	In addition to 15-LOX, ML351 has been reported to inhibit ALOX5 , therefore Western analysis of lipoxygenase and cyclooxygenase enzymes was performed (Fig. S4C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11562028	It may be due to the fact that after the Re-CDs entered the cells, a part of them reacted with the cell substances causing their structure to be disrupted, and remaining were excreted from the cells through metabolism, resulting in a gradual decrease of the intracellular fluorescence intensity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Bleeding was the most frequent AE, occurring in 36.6% of patients, with a median time to event of 24 months and predominantly in patients assuming concomitant antiplatelet or anticoagulant drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629143	CpG methylation at the CMV promoter in a CHO‐K1 cell line was measured at week 0 and week 10 of culture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CpG", "methyla...
PMC10919056	Subsequently, an in-depth analysis was conducted to explore the clinical value of the GRPS in assessing ccRCC prognosis, as well as its influence on the tumor mutational burden (TMB) and the tumor microenvironment (TME).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	We also provide evidence that some receptors do not require SNX9 and SNX18 nor β-arrestins for endocytosis, suggesting additional modes for GPCR endocytosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11703992	A volume of 20 µL of the sample should be added to each well designated for electrophoretic loading.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "volume", "of", "20", "µL", ...
PMC10047551	The inverse correlation between PD-L1 mRNA expression and DNA methylation could reflect an active function of the methylation of these positions in driving the transcriptional repression of PD-L1 and/or the fact that methylation is a passenger event for a given PD-L1 expression level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	From the LOTIS-2 trial primary data cut (April 6, 2020), overall response rate was 48.3% and median overall survival (OS) was 9.9 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11681005	Differential epigenomic reprogramming in bladder cancer (BLCA) related to androgen receptor (AR). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differential", "epigenomic", "reprogramming", "in", ...
PMC11718109	Scale bars, 10 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "10", "μm", "." ] } ]
PMC9777812	Cytoskeletal structure of the cultured BMECs was evaluated with cytokeratin 18 immunofluorescence and DAPI dying.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytoskeletal", "structure", "of", "the", "cultured", "BMECs", ...
PMC9596868	PA-1, A2780 and OVCAR3 cells were seeded at required densities in cell culture dishes.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PA-1", ",", "A2780", "and", "OVCAR3", ...
PMC6835428	Moreover, recent evidence connects E2F1 over-expression with reduced drug sensitivity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "recent", "evidence", "connects", "E2F1", "over-expression", "with", "reduc...
PMC11763111	Following priming, PBMCs were stained with antibodies specific for T cells, B cells, NK cells, DC, and macrophages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Followi...
PMC5443223	The cell cycle was analyzed using flow cytometry using 488 nm excitation and green emission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "cycle", "was", "analyzed", "using", "flow", ...
PMC10158546	Indeed, amyloid seeding activity within VV2 inoculum was approximately 2 logs lower compared to the other isolates (supplementary figure S5), explaining the inefficient seeding activity in ReN cells after challenge with sCJD VV2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	The use of radiopharmaceuticals for the treatment and diagnosis of oncological diseases allows for establishment of a diagnosis at an early stage and for carrying out adequate treatment more effectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8592717	PCA effectively suppressed palmitic acid (PA)-induced ROS generation and reversed the PA-impaired proliferation of neural stem/progenitor cells (NSPCs) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "effectively", "suppre...
PMC10900886	This resulted in 11% ± 2 EV-D68/A, 27% ± 8 EV-D68/B2, and 14% ± 6 EV-D68/A2 VP1 cells (Fig. 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	h Representative TEM images of mitochondria in U2OS cells; the black arrows indicate mitochondria (scale bars: 5 μm and 500 nm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC10926885	In summary, our investigation has shown that the expression of NDE1 is significantly elevated in several malignant tumours and is associated with a worse prognosis in numerous cancer types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Several EG5 inhibitors, such as SB-715992 (Ispinesib) (41) and Filanesib (ARRY-520) (42), have already been in clinical trials (Fig. 8A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	Plots of relative cell viability versus different drug treatments reveal that CXCR4 cells were intrinsically drug-resistant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plots", "of", "relative", "cell", "viability", "versus...
PMC9878562	Cell migration was calculated as percentage of the input (% migrated cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "migration", "was", "calculated", "as", "percentage", "of", ...
PMC9429973	Their training would be linked to several factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "training", "would", "be", "linked", "to", "several", "factors", "." ] } ]
PMC9429973	This effect was reverted when PRLR was knocked-down using CRISPR-Cas9 technology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "was", "reverted", "when", "PRLR", "was", "knocked-down", "using", "...
PMC10545062	The Institutional Animal Care and Use Committee approved this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Institutional", "Animal", "Care", "and", "Use", "Committee", "approved", "this", "study",...
PMC9268183	The two most quoted botanical families are Asteraceae and Ranunculaceae, and the most frequently reported species is Ranunculus parnassifolius, a high-mountain species, which is widely collected for this purpose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The time to oncological diagnosis had a median of 2 years (IQR 1 and 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "time", "to", "oncological", "diagnosis", ...
PMC9429973	However, a significant correlation was found between high CD 33 values and BLM, TET2 and WRN positivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "a", "significant"...

PMC11371747

In fact, treatment with either a conventional bolus of 5FU or with a continuous infusion (either 1 week or longer) can induce the expression of TS up to 3-5-fold (Peters et al., 1993; Codacci-Pisanelli et al., 1995).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11507371

These experiments are consistent with studies on epithelial cells, in which cell respiration was blocked immediately after the addition of plasma-activated medium (PAM).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11317131

During IntePACE, host cells harboring both the AP and CP are continuously added to a fixed volume vessel called the ‘lagoon’.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

These results aim to help clinicians in optimizing treatment approaches for patients with MM.

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PMC9119314

In addition, new antimalarials should be affordable and available to those who need them most, and it may also be argued that in the context of climate change/global warming, it is important that their production should not be environmentally damaging.

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PMC11543853

However, these experiments were performed at non-physiological pH, ion concentrations, and temperatures that may have stabilized the activated particles.

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PMC11775197

First, the question of how PPAR affects the growth and progression of CRC through the TME is not well understood.

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PMC8751435

a, b) Graphic representation of cell cycle distribution, data points are the percentage of cells in G0, G1, S, and G2/M at 24 h after treatment. (

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PMC9429973

Currently she is without critical stenosis or cerebrovascular events, maintaining only imaging follow-up.

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PMC11481779

In the case of the current models, like the aforementioned C.Origami or Akita, the model output is blurred.

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PMC3931643

Therefore, 4EBP1 loss might occur in a fraction of primary human DLBCL tumors as observed in the VAL cell line.

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PMC10452486

Some HLA-I polyreactive mAbs (MEM series) used for immunostaining confirm the existence of B2m-free variants in several cancer cells.

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PMC11021472

A monoclonal cell line (miR-150BSdel) was generated using CRISPR/Cas9 technology with two guide RNAs flanking the miR-150 binding site region in ZDHHC11 (Supplemental Fig. 7A).

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PMC11676169

Five to ten days post-infection, cell lines were evaluated for gene editing, i.e., BCAT1 silencing or overexpression.

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PMC11740508

A12621, Invitrogen®), according to manufacturer protocol.

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PMC11536589

These results showed that PKF-118-310 has the ability to repress the MGST1 expression and induce ferroptosis in MRTX1133-resistant PDAC cells.

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PMC9429973

All patients started a 14-day run-in of HCQ at their intended HCQ dose level (DL) before the first cycle of HCQ-Kd.

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PMC11779605

Further study of these specific differentially expressed genes and pathways has the potential to identify biomarkers of metastases and drug targets for inhibiting metastases.

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PMC10568263

10 μL of anti-HSP70 was added dropwise on the surface of EN-LC/Au@MnO2/MoO3/SPEs and incubated at 37 °C for 1 h. The unbound anti-HSP70 on the electrode surface was washed with DI water and dried at 37 °C for 30 min.

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PMC11082662

Due to the high expression level of SMPDL3B, we selected the SK-OV-3 and HEY cell lines for subsequent functional experiments.

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PMC8068766

The p-value threshold was taken as 0.01 while selecting the DEG lists.

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PMC9878278

Similar to what we observed with RIG-I silencing, MDA5 silencing also led to a significant increase (~200%) in ZIKV titers as compared to siCtrl cells only at 48 and 120 hpi (Figure 4C).

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PMC11075223

was often used for treating arthritis in the Far East: OAH19T (10, 20, 40 μg/mL) protected chondrocytes through down-regulating the levels of MMP-1, MMP-3, aggrecanase-1, aggrecanase-2 and promoting cell proliferation .

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PMC11587606

These experiments were repeated two times under identical conditions.

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PMC6268318

= intraperitoneal; p.o.

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PMC10926885

C1 (wound healing); C2 (IFN‐gamma dominant); C3 (inflammatory); C4 (lymphocyte depleted); C5 (immunologically quiet); C6 (TGF‐b dominant).

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PMC11365983

A–C) Foxc1 shRNA inhibition significantly reduced the level of total Pdgfrα, and auto-phosphorylated pY754-Pdgfrα in serum-starved NIH3T3 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", ...

PMC11632064

Gene functional analysis (g:Profiler; Reactome) of additional significantly up-regulated transcripts, related to Fig 2B and C. (B) Gene functional analysis (g:Profiler; Reactome) of additional significantly down-regulated transcripts, related to Fig 2B and D. (C) Top gene set enrichments identified by GSEA (Hallmarks, ...

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PMC10914904

In particular, the integration of the small fragment derived from vtRNA1-2, which was designated svtRNA1-2, was observed.

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PMC2614415

Three independent biological replicates were performed, luminescence measured and data analyzed.

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PMC10606998

Unlike protons, photon irradiation transmits energy all the way through the patient’s body, increasing initially and decreasing exponentially as photons are absorbed.

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PMC11472569

ABC transporters are a family of membrane proteins that utilize ATP hydrolysis to transport a diverse array of substrates, including ions and macromolecules, across extra- and intercellular membranes.

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PMC11638255

Furthermore, copper chelation treatment caused neutrophils to supersede tumor cells when comparing incoming interaction strengths, alluding to the dampening of tumoral-induced immunosuppression (Fig. 5c; Supp.

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PMC11543853

Electron micrographs were recorded in the counting mode of the detector at a magnification of 105,000×, which corresponds to a pixel size of 1.34 Å. Total electron exposure was 50 e / Å, and defocus values ranged from −1.8 to −3.0 μm.

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PMC8068766

With this aim, the results of an Affymetrix expression array were analyzed and the DEG lists were identified using limma analysis.

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PMC11075223

In order to better apply to the clinic, the study on the differences between raw and processed products should be further deepened.

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PMC11783017

In the osteosarcoma-bearing model, the nanocomposite hydrogel significantly enhanced tumor T cell infiltration, induced effective anti-tumor immunity and attenuated lung metastasis.

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PMC9621239

Additionally, to confirm the difference in the evolution of the HBV X gene between intra-patient tumour and non-tumour tissues, the phylogenetic analysis for the haplotypes of the HBV X gene in the liver tissue of each patient with HCC was performed.

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PMC7090062

Nevertheless, combining autophagy inhibitors with first-line therapies has succeeded in overcoming resistance or increasing sensitivity to the front-line drugs in clinical hematopoietic disorders, including several types of leukemia.

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PMC7081114

Cumulative survival was compared using the Kaplan–Meier method with the log-rank test.

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PMC11745600

Their body weight, nonfasting blood glucose, and survival were measured from 4 wk of age.

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PMC11734514

Bar graph showing protein expression of (B) PTEN, (C)AKT, (D) p-AKT, (E) p-mTOR, and (F) STAT-3 obtained through Western blotting in A549 cells treated with C. aerizusa extract.

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PMC11700247

Working model: time line and schematic representation of in vivo A20 tumor–bearing mice treated with RT followed by CART-19 cell injection.

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PMC7334607

Experimental time points (x axis) represent which step in the drug cycle the replicates have just recovered from.

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PMC6222635

The morphology changes in HeLa cells after treatment with F1 and F3 at a concentration of 400 μg/mL for 24 and 48 h was observed.

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PMC9429973

As shown in Fig K, EBV+ B cells exhibited a wider and more distribution in RR-AITL (Fig L).

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PMC9429973

The booster dose increased SARS-CoV-2 spike-specific T cells in both MMD and MMR reaching the 100% of responder patients with an increased percentage of IL-2+CD4+ T cells compared to full vaccination.

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PMC11794588

Its oxidative stress-inducing properties align with its role in liver cancer treatment.

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PMC11568601

There have been many attempts to target ER stress-associated proteins, including IRE1.

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PMC7305184

In this test the sensitive parental cells are compared to the surviving daughter resistant cells by viability assays.

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PMC10170482

We used the human hepatoblastoma HepG2 cell line (American Type Culture Collection, ATCC, Manassas, VA, USA) and human hepatocellular carcinoma cell line Alexander (PLC/PRF/5, ATCC, Manassas, VA, USA) in this study.

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PMC11344246

In total this gave us 820 edges involving 659 vertices (unique human proteins).

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PMC11359735

Metabolic labeling of P. berghei sporozoites with [H]-palmitic acid and [H]-ethanolamine.

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PMC11706297

In an attempt to find effective, selective, and targeted anticancer agents, we synthesized new naphthalene-linked pyrazoline–thiazole hybrids and screened their anticancer activity against A549 and MCF-7 cell lines.

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PMC9429973

ASCT was performed in only 4 cases (3 after RC1 and 1 after relapse).

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PMC11763111

Deleting class I of human leukocyte antigen (HLA-I) and class II of human leukocyte antigen (HLA-II) can prevent rejection by allogeneic T cells; however, natural killer (NK) cell rejection due to the loss of self-recognition remains unresolved.

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PMC11188874

Data were further processed using Skyline v22.2.0.255.

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PMC10093184

Analysis revealed that the genetic background of COS3600/COS3600B, COS4074, and COS4288 cell lines came from three different animals.

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PMC11297139

Scale bar: 5 μm.

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PMC11023271

We examined the protein contents of fractions from the 100KD filters on SDS-PAGE and found that the predominant protein band in the >100K fraction corresponded to bovine serum albumin (BSA) (Fig 5A).

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PMC7171147

a Real-time PCR of FASN in A2780cis-scrambled and A2780cis-shCOL11A1 and in ES2 cells co-cultured with CAF-scrambled or CAF-shCOL11A1.

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PMC11680562

Subsequently, a 10 mL solution of 0.2 M Cu(NO3)2 3H₂O was gradually added dropwise to the extract.

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PMC9429973

Due to the selectivity to asparagine depletion, we then investigated whether SOD2 inhibition mediates a broader amino acid starvation response.

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PMC10213179

The ATOP aptamer or the SCR control aptamer were incubated on cells for 1 h and the internalized aptamer RNA recovered after a stringent high-salt wash (0.5M NaCl) was assessed by qRT-PCR.

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PMC11694066

Cisplatin was used as the positive control.

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PMC11024707

To the best of our knowledge, there is no study comparing the individuals diagnosed with ASD to their non-diagnosed siblings In this study, mi-RNAs that were consistently shown to be associated with ASD in the previous research, –are thought to be closely associated with ASD pathogenesis– were investigated and it is as...

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PMC11745600

The C96Y mutation in Ins2 reported in Akita mice, which is inherited as an autosomal dominant trait, is known to cause hyperglycemia and severe diabetes in homozygous and heterozygous mice.

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PMC6642070

We scanned the ENO3 promoter (−2000 to +100) and found 3 putative p53RRE sites with >90% identity (Fig. 5a).

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PMC9429973

Its overexpression restores cell proliferation control by stabilizing p53 activity, and DNA damage repair by rescuing the H3K36me3 mark.

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PMC11754432

In addition to 15-LOX, ML351 has been reported to inhibit ALOX5 , therefore Western analysis of lipoxygenase and cyclooxygenase enzymes was performed (Fig. S4C).

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PMC11562028

It may be due to the fact that after the Re-CDs entered the cells, a part of them reacted with the cell substances causing their structure to be disrupted, and remaining were excreted from the cells through metabolism, resulting in a gradual decrease of the intracellular fluorescence intensity.

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PMC9429973

Bleeding was the most frequent AE, occurring in 36.6% of patients, with a median time to event of 24 months and predominantly in patients assuming concomitant antiplatelet or anticoagulant drugs.

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PMC11629143

CpG methylation at the CMV promoter in a CHO‐K1 cell line was measured at week 0 and week 10 of culture.

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PMC10919056

Subsequently, an in-depth analysis was conducted to explore the clinical value of the GRPS in assessing ccRCC prognosis, as well as its influence on the tumor mutational burden (TMB) and the tumor microenvironment (TME).

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PMC11544122

We also provide evidence that some receptors do not require SNX9 and SNX18 nor β-arrestins for endocytosis, suggesting additional modes for GPCR endocytosis.

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PMC11703992

A volume of 20 µL of the sample should be added to each well designated for electrophoretic loading.

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PMC10047551

The inverse correlation between PD-L1 mRNA expression and DNA methylation could reflect an active function of the methylation of these positions in driving the transcriptional repression of PD-L1 and/or the fact that methylation is a passenger event for a given PD-L1 expression level.

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PMC9429973

From the LOTIS-2 trial primary data cut (April 6, 2020), overall response rate was 48.3% and median overall survival (OS) was 9.9 months.

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PMC11681005

Differential epigenomic reprogramming in bladder cancer (BLCA) related to androgen receptor (AR). (

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PMC11718109

Scale bars, 10 μm.

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PMC9777812

Cytoskeletal structure of the cultured BMECs was evaluated with cytokeratin 18 immunofluorescence and DAPI dying.

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PMC9596868

PA-1, A2780 and OVCAR3 cells were seeded at required densities in cell culture dishes.

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PMC6835428

Moreover, recent evidence connects E2F1 over-expression with reduced drug sensitivity .

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PMC11763111

Following priming, PBMCs were stained with antibodies specific for T cells, B cells, NK cells, DC, and macrophages.

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PMC5443223

The cell cycle was analyzed using flow cytometry using 488 nm excitation and green emission.

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PMC10158546

Indeed, amyloid seeding activity within VV2 inoculum was approximately 2 logs lower compared to the other isolates (supplementary figure S5), explaining the inefficient seeding activity in ReN cells after challenge with sCJD VV2.

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PMC11721277

The use of radiopharmaceuticals for the treatment and diagnosis of oncological diseases allows for establishment of a diagnosis at an early stage and for carrying out adequate treatment more effectively .

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PMC8592717

PCA effectively suppressed palmitic acid (PA)-induced ROS generation and reversed the PA-impaired proliferation of neural stem/progenitor cells (NSPCs) .

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PMC10900886

This resulted in 11% ± 2 EV-D68/A, 27% ± 8 EV-D68/B2, and 14% ± 6 EV-D68/A2 VP1 cells (Fig. 2C).

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PMC11670407

h Representative TEM images of mitochondria in U2OS cells; the black arrows indicate mitochondria (scale bars: 5 μm and 500 nm).

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PMC10926885

In summary, our investigation has shown that the expression of NDE1 is significantly elevated in several malignant tumours and is associated with a worse prognosis in numerous cancer types.

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PMC10547921

Several EG5 inhibitors, such as SB-715992 (Ispinesib) (41) and Filanesib (ARRY-520) (42), have already been in clinical trials (Fig. 8A).

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PMC5308810

Plots of relative cell viability versus different drug treatments reveal that CXCR4 cells were intrinsically drug-resistant.

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PMC9878562

Cell migration was calculated as percentage of the input (% migrated cells).

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PMC9429973

Their training would be linked to several factors.

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PMC9429973

This effect was reverted when PRLR was knocked-down using CRISPR-Cas9 technology.

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PMC10545062

The Institutional Animal Care and Use Committee approved this study.

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PMC9268183

The two most quoted botanical families are Asteraceae and Ranunculaceae, and the most frequently reported species is Ranunculus parnassifolius, a high-mountain species, which is widely collected for this purpose.

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PMC9429973

The time to oncological diagnosis had a median of 2 years (IQR 1 and 3).

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PMC9429973

However, a significant correlation was found between high CD 33 values and BLM, TET2 and WRN positivity.

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