OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC6182045	We found that TZ97008 has 84.1% pairwise identity to the LANL clade C consensus amino acid sequence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "that", "TZ97008", "has"...
PMC11574271	In total, 5637 cells were stimulated with MSP for 24 h, and J82-oeRON cells were treated with RON inhibitor BMS-777607 for 24 h. G Western blot analysis was performed to assess the phosphorylation status of RON.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11026382	a Sequencing-based growth rate measurements for DHFR F31V in three TYMS backgrounds: R166Q (red), Q33S (cyan), and WT (black).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	Compound 25, which still showed the highest rate of clearance of any of the compounds tested in dog, possessed a similar clearance as a fraction of hepatic blood flow in both mouse and dog.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11243198	The results from both of the Hh-responsive assays showed BAS 07019774 and Z27610715 were the most active (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", ...
PMC11590870	In previous work, Moringa oleifera leaf peptides (MOPHs) with antioxidant potential were generated and identified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "previous", "work", ",", "Moringa...
PMC8913139	For example, miR-1225-5p has been reported to be downregulated and act as a tumor inhibitor in GBM by targeting IRS1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC10523483	In cisplatin-treated cells, knockout of H1.2 decreased nuclear NRF2 levels, hindered GCLC transcription, and down-regulated GSH content (Fig. 7 E–G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8658661	Other signs of an HB nature include the corresponding parameters of the Wnt/β-catenin signaling pathway and dysregulation of cell growth and survival pathways such as fetal and embryonal HB , a characteristic deletion of the third exon of the CTNNB1 gene, which is identical to that described in epithelial type HB, as w...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9856122	An herbal formulation of COVIDEX also contains BBR (NCT05228626) targeting SARS-CoV-2 in a clinical trial sponsored by Makerere University in Uganda.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", ...
PMC9429973	In 35% of patients the diagnosis was not defined yet.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "35", "%", "of", "patients", "the", "diagnosis", "was", "not", "defined", ...
PMC11247842	In addition to rs109848760 and rs208358909 being lead SNPs based on MTAG multi-trait meta-analysis for, respectively, CM and SCS, these two SNPs showed an enriched localization in liver-active elements, and the latter lead SNP, for SCS, showed a trans-eQTL effect in liver on BTA18 (gene ANKRD27) in another study .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9581083	The original recipe consists of Nepeta, Fangfeng, Bupleurum, Poria, Platycodon, Chuanxiong, Qianghuo, Duhuo, Citrus aurantium, Licorice, Ginger, and other medicinal materials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11617590	Therefore, in the subsequent experiments, the maximum concentration of SFN was set at 100 μM for 24 h. The staining method using Annexin V and PI can detect and quantify apoptotic and necrotic cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10495912	In this study, HepG2 cell survival, reactive oxygen species (ROS) production, cell membrane integrity, and changes of superoxide dismutase (SOD)/ catalase (CAT) activity were evaluated following incubation of HepG2 cells with 31 μM hydrogen peroxide and different concentrations of TQ (18.5, 37 and 75 μM).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301931	Statistical significance was defined as p < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "defined", "as", "p", "<", "0.05", "." ] } ]
PMC10196713	First-line chemotherapy is a combination of carboplatin and paclitaxel (3), and the response to platinum agents contributes the most to therapeutic efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11699465	The immunocomplexes pulled down were further used for immunoblotting detection or MS analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "immunocomplexes", "pulled", "down", "were", "further", "used", "for"...
PMC7987994	Probably, the serum should be added after extraction for the successful cell cultivation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Probably", ",", "the", "serum", "should", "be", "added", "after"...
PMC6312945	However, most studies tend to examien hepatitis C virus (HCV) on the relationship between miR-345 and viral replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "m...
PMC9429973	The historical precedent demonstrating similar clinical outcomes among patients with HR-MDS and AML, particularly low blast count AML (Estey 2021), supports further development of the combination of tamibarotene plus aza in the HR-MDS population, with the opportunity to improve upon the clinical outcomes of standard of...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213179	C and D) Quantification of the migration assay in Boyden chambers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "and", "D", ")", "Quantification", "of", "the", "migration", "assay", ...
PMC9000591	The inhibition of DPPH and ABTS radicals was determined based on the discoloration of the final solution with the C. speciosa fraction treatments and evaluated as the decreased percentage of absorbance in a comparison with the negative control (MeOH) at 517 nm and 734 nm, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	However, in the case of oxidative stress, the cysteine thiols of Keap1 react with various oxidative and electrophilic molecules, leading to conformational changes of the Keap1 molecule and disruption of the interactions between Nrf2 and Keap1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The reported incidence ranges around 9-17% at 15 years after transplantation and they are responsible for 5-10% of late deaths.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Survival intervals of both groups of patients were comparable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "intervals", "of", "both", "groups", "of", "patients", "were", "comparable", "." ] } ]
PMC11782780	Pearson correlation analysis was conducted between EBF3 and these 11 DEmiRNAs, revealing a notable negative correlation of hsa-miR-301b-3p with EBF3 (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11344246	It is reported to have direct CDK1 enzyme inhibition (Ki of 35 nM) and a modest cell activity of 9 μM (for complete inhibition of cell cycle at HCT116 and HeLa cancer cell lines) (41).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612794	However, as in the case of CENP-C/Dsn1 cells, substantial growth defects were not observed in CENP-C/CENP-T cells (Figure S6F), indicating that CENP-C cells are still viable even when the interaction between CENP-T phospho-sites and Mis12C is impaired.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	Cancer cells were grown on a Lab-Tek Chamber slide (Sigma Chemicals, St. Louis, MO, USA) overnight at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Image: Summary/Conclusion: In this 12-week Phase 2a study, vamifeport had a favorable safety and tolerability profile and showed promising target engagement and pharmacodynamic effects on serum iron and TSAT levels versus placebo in adults with NTDT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	e Effects of the intraperitoneal administration of exendin 9–39 (50 mg/kg) or BCTC (5 mg/kg) on body temperature (mean ± S.E.M., n = 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11119602	Structural studies support the notion that TG2-L only adopts an ‘open’ structure and becomes enzymically active under conditions where the intracellular GTP levels drop and/or those of calcium rise, e.g., as occurs when cells become severely stressed or undergo apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	Again, we found that metabolic and signaling pathways were significantly enriched in transcripts differentially regulated by pHi in our RNA-Seq dataset, with Notch1 being the most significantly enriched signaling pathway and glycolysis being the most significantly enriched metabolic pathway (Fig. S3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11361748	These findings are consistent with the PLA data but do not conclusively inform on the pool of K17 that interacts with RACK1 and regulates PKCα.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Methods: A systematic search was performed of the Embase and MEDLINE databases to identify trials related to use of 3 combination iron chelation therapies (DFP+DFO, DFX+DFO, or DFP+DFX) in patients with thalassemia syndromes or sickle cell disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6160470	P-glycoprotein (P-gp) belongs to the ABC transporter superfamily and is encoded by ABCB1, also known as multidrug resistance 1 (MDR1) gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10850553	Enzymatic cleavage of C5 into C5a by Plasmin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enzymatic", "cleavage", "of", "C5", "into", "C5a", "by", "Plasmin", "." ] } ]
PMC11265931	The TUNEL assay was also applied in order to detect apoptotic DNA fragmentation, which is commonly used to identify and quantify apoptotic cells, as well as to detect excessive DNA breakdown in cells (Loo, 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In a global phase I/II trial (NCT03395210) of heavily pretreated patients with long-standing disease, the Bruton tyrosine kinase inhibitor rilzabrutinib showed a rapid and durable platelet count increase and was well tolerated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574029	Data are presented as the mean ± SEM of three independent experiments, p < 0.05, p < 0.01, p < 0.001, **p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	In a follow-up study, it was shown that the invasive cancer cells resulted in phenotypically aggressive tumors that resulted when peptides got embedded and started replicating the natural ECM sites for example the collagen and laminin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Assays were performed in Tris-HCl (20 mmol/L, pH 7.6), 5 mmol/L MgCl2, 2 mmol/L ATP, 1 mmol/L DTT, and 10% glycerol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Moreover, 84.6% of IGLV3-21 cases carried non-stereotyped immunoglobulin genes while the remaining stereotyped IGLV3-21 cases were subset #2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11397654	Treatment using the complex was the most effective and significantly improved the survival rate compared to PBS, MTX, and 36 treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatme...
PMC8567602	Similarly, synovial sarcoma tumors demonstrated strong coprecipitation of SMARCB1 with PBRM1 and DPF2 and the reciprocal coprecipitations, albeit with low levels of SMARCB1 present in the input (Fig. 4D and E; Supplementary Fig. S4A and S4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092418	Effects of tyrosine kinase inhibitors (TKIs) on cell signaling on brain tumor cell line A172 in the presence or absence of ligands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC7338939	and R(u(t)) are calculated for both IV and IT injections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "and", "R(u(t", ")", ")", "are", "calculated", "for", "both", "IV", "and", ...
PMC9429973	N. TRABELSI, I. Kraiem, S. Menif, S. Abbes Institut Pasteur de Tunis, Tunis, Tunisia Background: Band 3 is the most abundant transmembrane protein in the erythrocyte, which is encoded by the SLC4A1 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10538569	Taken together, our results suggest that using GPI-scFv-based MAVIs that can effectively restrict both HIV-1 cis- and trans-infection may be a promising approach to achieve a functional cure for HIV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707832	Investigations extending beyond α-mannosidosis have unveiled notable insights into the potential role of MAN2B1 in inflammatory conditions, particularly in macrophage infection and activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11562028	The cells were then placed under a fluorescence inverted microscope and photographed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "placed", "under", "a", "fluorescence", "inverted...
PMC9143157	Since 2002, a combination of gemcitabine plus docetaxel was widely used as a first-line option for locally advanced or metastatic leiomyosarcoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "200...
PMC9429973	Lymphopenia at diagnosis is an additional, inexpensive and easy value to predict relapse or refractory disease in DLBCL with low IPI score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lymphop...
PMC9429973	These drugs may allow for use of less chemotherapy and improve remission durations and overall survival (OS) in older pts with newly diagnosed B-ALL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11680049	The localization of terpenoids was determined using NADH reagent .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "localization", "of", "terpenoids", "was", "determined", "using", "NADH", "reagent", "." ] } ]
PMC9429973	This is the first-in-human study of autologous HBG1/2 promoter-modified CD34+ HSPCs (RM-001) in TDT and both patients were treated successfully without SAE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6364197	Collagen, a major extracellular matrix (ECM) component, is coated to scaffold to make cell adhere better and as a ligand of DDR1 (11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At baseline, the gender ratio, paraprotein isotype, ISS and R-ISS stage were comparable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "baseline", ",", "the", "gender", "ratio", ...
PMC9429973	Methods: In this monocentric retrospective study, we included consecutive adult patients (≥18 years of age) who were diagnosed with non-M3 AML between 2010 and 2020.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The incidence of adverse events was high (75%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "incidence", "of", "adverse", "events", "was", "high", "(", "75", "%", ")...
PMC11521786	Following a five-dose treatment scheme ( Figure 6A ), statistically significant differences in tumor growth were observed between mice treated with Mv-HER3-induced PAbs and those treated with PAbs purified from nonimmunized rabbits (239 mm ± 65.7 mm vs. 568.1 mm ± 187 mm, p < 0.0001) ( Figure 6B ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Edge widths correlate with the associated substrate site “phosphosignal”, and edge colors indicate the analysis on which the kinase–substrate relationship was based (coral: PSP, cornflowerblue: NWK, forestgreen: both).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	Additionally, treatment with CATR combined with cisplatin increased C-C3 expression in the 143B-EFHD1 group compared to treatment with cisplatin alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ...
PMC11711063	All antibodies used are listed in Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "antibodies", "used", "are", "listed", "in", "Table", "S1", "." ] } ]
PMC11628309	MPP+ exposure increases lysosomal cholesterol levels and stimulates α-synuclein aggregation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MPP+", "exposure", "increases", "lysosomal", "cholesterol", "levels", "and", "stimulates", "α-synuclei...
PMC11699178	P < 0.01, ***P < 0.001 Exploring the molecular mechanisms of Dioscorea nipponica Makino extract on inhibiting the proliferation, migration, invasion capabilities, and angiogenesis of ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5415764	Similar to the P-gp inhibition results, the level of cytotoxicity among free P+T, P/LPN+T, and P/iRGD LPN+T was comparable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "t...
PMC11490153	The highest percentages of apoptotic cells were observed in MDA-MB-231 and A-375 cells treated with citral-AlgNPs (84 ± 5%) and C. citratus-AlgNPs (92 ± 5%), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8584319	MAPKs are serine/threonine protein kinases that activate multiple cellular signaling pathways such as gene expression and programmed cell death through sequential phosphorylation of different molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6468656	Moreover, ghrelin was also observed to induce cell migration by triggering the activation of GHSR/CaMKII/AMPK/NFκB signaling pathway in glioma cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC11766174	Progress has been made in understanding the molecular pathogenesis of HIV and has since led to the development of combination antiretroviral therapy (cART).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Anti-teclistamab Abs were not detected in any pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-teclistamab", "Abs", "were", "not", "detected", "in", "any", "pts", "." ] } ]
PMC9412887	The average particle size of ANCs was approximately 30 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "particle", "size", "of", "ANCs", "was", "approximately", "30", "nm", "."...
PMC2196094	The nucleotide sequence is deposited in GenBank under the accession number U67914.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "nucleotide", "sequence", "is", "deposited", "in", "GenBank", "under"...
PMC2196094	The PCR product was loaded on a 1% low melting point agarose gel, and the DNA from a broad band of ∼500 bp in size was isolated and cloned into a plasmid vector.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	Dendrograms are generated in accordance with hierarchical clustering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dendrograms", "are", "generated", "in", "accordance", "with", "hierarchical", "clustering", "." ] } ]
PMC11723947	With their binding partners, which include the corepressor TRIM28 and the lysine methyltransferases SETDB1 and SUV39H1, they are critically involved in CD4 and CD8 T cell programming in response to activating and polarizing signals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628904	Image showing method of quantification for burn depth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", "showing", "method", "of", "quantification", "for", "burn", "depth", "." ] } ]
PMC11462673	As depicted in Fig. 3B, the fluorescence signal intensity of mice in the LDB1 knockdown group demonstrated a substantial reduction in comparison to the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	DIO2 is localized in the ER, unlike other types of deiodinases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DIO2", "is", "localized", "in", "the", "ER", ",", "unlike", "other", "type...
PMC2614416	Five scan events are recorded for each data acquisition cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Five", "scan", "events", "are", "recorded", "for", "each", "data", "acquisition", "cycle", ...
PMC11721064	A and B IF staining (A) and quantification of CK12 + cells (B) showed that Stattic treatment significantly decreased the population of CK12 + cells (CK12: p < 0.001) (scale bar = 50 μm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8632470	The result obtained in our study is comparable with the previously reported result given by Kwon and coworkers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "result", "obtained", "in", "our...
PMC9429973	S. Di Folca, V. Marafioti, S. barbato, S. Avilia, F. Grimaldi, A. Severino, M. Picardi, L. Luciano, G. Battipaglia, F. Pane Ematologia, AOU Federico II, napoli, Italy Background: Combination of carmustine, etoposide, cytarabine, melphalan (BEAM) is a commonly used regimen for autologous stem cell transplantation (auto-...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	We expanded the life span of HDF by expression of human telomerase reverse transcriptase (hTERT; HDF-T).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "expanded", "the", "life", ...
PMC10847511	To our knowledge, there are currently no data on such HR functional assays across multiple cancer cell lines, but such data may shed light on this issue in the future.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672881	The RNAseq data and metabolomic pathway analysis provide complementary insights into the effects of thymoquinone (TQ) and curcumin (CU) on A375 cell lines, revealing a comprehensive mechanism of action against melanoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC11765988	Pathophysiological causation is considered possible by Ishihara et al., but cross-reactivity between Borrelia and other agents suspected to trigger the development of sarcoidosis (molecular mimicry) was not excluded .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222635	The C-NMR signals for DWDOP1 and FWDOP1 were also almost the same.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "C-NMR", "signals", "for", "DWDOP1", "and", "FWDOP1", "were", "also", ...
PMC11285179	These include the hypoxia-inducible factor-1α (HIF-1α) signaling pathway under low oxygen conditions, interaction with vascular endothelial growth factor (VEGF), involvement of anti-inflammatory factors and growth factors, cell–cell interactions, as well as the nuclear factor-κB (NF-κB) signaling pathway and hormonal r...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	After collection, the samples were assessed using a UV spectrophotometer at 266 nm wavelength to quantify the released drug accurately.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "collection", ...
PMC9429973	Our interpretation on these findings is that JAK2V617F is per se a strong risk factor for unusual venous thrombosis while CALR mutation must be enriched for additional non-driver alterations, needing a second hit to drive to thrombosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10571053	FINs inhibit P-gp and ABCG2 transport activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FINs", "inhibit", "P-gp", "and", "ABCG2", "transport", "activity", "." ] } ]
PMC7723249	Epithelial cells have asymmetric plasma membranes containing distinct apical and basolateral domains with differences in the expression/distribution of cellular proteins (including the viral receptors), which affect viral entry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	In 2019, Zhang et al. reported the first human clinical trial involving CD4 CAR-T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "2019", ",", "Zhang", "et", "al.", "reporte...
PMC6222635	The FWDOP1 C-NMR spectrum showed signals at δ102.48, 100.11, 78.43, 76.49, 75.00, 73.86, 72.74, 71.40, 69.93, 60.45, 23.17, and 20.53.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Non CR or progression at +100 day and early relapse (< 12 months) had a very negative impact on OS (median of 9 months: Non CR/progression p-value < 0.001/ HR 3, 3 (CI 1.9-6); early relapse p-value <0.001/HR 8.7 (CI 4.8-16.4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	TFRC was measured by qPCR and IB in Bel-7404 cells with or without TRIB2 knocked out (A) and in SK-Hep1 cells with or without TRIB2 overexpressed (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...
PMC11703992	Apart from eQTL, we also conducted MR analysis on protein and metabolite level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apart", "from", "eQTL", ",", "we", "also", "conducted", "MR", ...

PMC6182045

We found that TZ97008 has 84.1% pairwise identity to the LANL clade C consensus amino acid sequence.

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PMC11574271

In total, 5637 cells were stimulated with MSP for 24 h, and J82-oeRON cells were treated with RON inhibitor BMS-777607 for 24 h. G Western blot analysis was performed to assess the phosphorylation status of RON.

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PMC11026382

a Sequencing-based growth rate measurements for DHFR F31V in three TYMS backgrounds: R166Q (red), Q33S (cyan), and WT (black).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11345828

Compound 25, which still showed the highest rate of clearance of any of the compounds tested in dog, possessed a similar clearance as a fraction of hepatic blood flow in both mouse and dog.

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PMC11243198

The results from both of the Hh-responsive assays showed BAS 07019774 and Z27610715 were the most active (Table 1).

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PMC11590870

In previous work, Moringa oleifera leaf peptides (MOPHs) with antioxidant potential were generated and identified.

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PMC8913139

For example, miR-1225-5p has been reported to be downregulated and act as a tumor inhibitor in GBM by targeting IRS1 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...

PMC10523483

In cisplatin-treated cells, knockout of H1.2 decreased nuclear NRF2 levels, hindered GCLC transcription, and down-regulated GSH content (Fig. 7 E–G).

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PMC8658661

Other signs of an HB nature include the corresponding parameters of the Wnt/β-catenin signaling pathway and dysregulation of cell growth and survival pathways such as fetal and embryonal HB , a characteristic deletion of the third exon of the CTNNB1 gene, which is identical to that described in epithelial type HB, as w...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9856122

An herbal formulation of COVIDEX also contains BBR (NCT05228626) targeting SARS-CoV-2 in a clinical trial sponsored by Makerere University in Uganda.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", ...

PMC9429973

In 35% of patients the diagnosis was not defined yet.

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PMC11247842

In addition to rs109848760 and rs208358909 being lead SNPs based on MTAG multi-trait meta-analysis for, respectively, CM and SCS, these two SNPs showed an enriched localization in liver-active elements, and the latter lead SNP, for SCS, showed a trans-eQTL effect in liver on BTA18 (gene ANKRD27) in another study .

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PMC9581083

The original recipe consists of Nepeta, Fangfeng, Bupleurum, Poria, Platycodon, Chuanxiong, Qianghuo, Duhuo, Citrus aurantium, Licorice, Ginger, and other medicinal materials.

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PMC11617590

Therefore, in the subsequent experiments, the maximum concentration of SFN was set at 100 μM for 24 h. The staining method using Annexin V and PI can detect and quantify apoptotic and necrotic cells .

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PMC10495912

In this study, HepG2 cell survival, reactive oxygen species (ROS) production, cell membrane integrity, and changes of superoxide dismutase (SOD)/ catalase (CAT) activity were evaluated following incubation of HepG2 cells with 31 μM hydrogen peroxide and different concentrations of TQ (18.5, 37 and 75 μM).

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PMC11301931

Statistical significance was defined as p < 0.05.

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PMC10196713

First-line chemotherapy is a combination of carboplatin and paclitaxel (3), and the response to platinum agents contributes the most to therapeutic efficacy.

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PMC11699465

The immunocomplexes pulled down were further used for immunoblotting detection or MS analysis.

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PMC7987994

Probably, the serum should be added after extraction for the successful cell cultivation.

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PMC6312945

However, most studies tend to examien hepatitis C virus (HCV) on the relationship between miR-345 and viral replication.

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PMC9429973

The historical precedent demonstrating similar clinical outcomes among patients with HR-MDS and AML, particularly low blast count AML (Estey 2021), supports further development of the combination of tamibarotene plus aza in the HR-MDS population, with the opportunity to improve upon the clinical outcomes of standard of...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10213179

C and D) Quantification of the migration assay in Boyden chambers.

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PMC9000591

The inhibition of DPPH and ABTS radicals was determined based on the discoloration of the final solution with the C. speciosa fraction treatments and evaluated as the decreased percentage of absorbance in a comparison with the negative control (MeOH) at 517 nm and 734 nm, respectively.

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PMC11507371

However, in the case of oxidative stress, the cysteine thiols of Keap1 react with various oxidative and electrophilic molecules, leading to conformational changes of the Keap1 molecule and disruption of the interactions between Nrf2 and Keap1.

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PMC9429973

The reported incidence ranges around 9-17% at 15 years after transplantation and they are responsible for 5-10% of late deaths.

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PMC9429973

Survival intervals of both groups of patients were comparable.

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PMC11782780

Pearson correlation analysis was conducted between EBF3 and these 11 DEmiRNAs, revealing a notable negative correlation of hsa-miR-301b-3p with EBF3 (Fig. 4B).

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PMC11344246

It is reported to have direct CDK1 enzyme inhibition (Ki of 35 nM) and a modest cell activity of 9 μM (for complete inhibition of cell cycle at HCT116 and HeLa cancer cell lines) (41).

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PMC11612794

However, as in the case of CENP-C/Dsn1 cells, substantial growth defects were not observed in CENP-C/CENP-T cells (Figure S6F), indicating that CENP-C cells are still viable even when the interaction between CENP-T phospho-sites and Mis12C is impaired.

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PMC11406030

Cancer cells were grown on a Lab-Tek Chamber slide (Sigma Chemicals, St. Louis, MO, USA) overnight at 37°C.

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PMC9429973

Image: Summary/Conclusion: In this 12-week Phase 2a study, vamifeport had a favorable safety and tolerability profile and showed promising target engagement and pharmacodynamic effects on serum iron and TSAT levels versus placebo in adults with NTDT.

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PMC11612315

e Effects of the intraperitoneal administration of exendin 9–39 (50 mg/kg) or BCTC (5 mg/kg) on body temperature (mean ± S.E.M., n = 5).

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PMC11119602

Structural studies support the notion that TG2-L only adopts an ‘open’ structure and becomes enzymically active under conditions where the intracellular GTP levels drop and/or those of calcium rise, e.g., as occurs when cells become severely stressed or undergo apoptosis.

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PMC11489351

Again, we found that metabolic and signaling pathways were significantly enriched in transcripts differentially regulated by pHi in our RNA-Seq dataset, with Notch1 being the most significantly enriched signaling pathway and glycolysis being the most significantly enriched metabolic pathway (Fig. S3C).

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PMC11361748

These findings are consistent with the PLA data but do not conclusively inform on the pool of K17 that interacts with RACK1 and regulates PKCα.

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PMC9429973

Methods: A systematic search was performed of the Embase and MEDLINE databases to identify trials related to use of 3 combination iron chelation therapies (DFP+DFO, DFX+DFO, or DFP+DFX) in patients with thalassemia syndromes or sickle cell disease.

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PMC6160470

P-glycoprotein (P-gp) belongs to the ABC transporter superfamily and is encoded by ABCB1, also known as multidrug resistance 1 (MDR1) gene.

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PMC10850553

Enzymatic cleavage of C5 into C5a by Plasmin.

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PMC11265931

The TUNEL assay was also applied in order to detect apoptotic DNA fragmentation, which is commonly used to identify and quantify apoptotic cells, as well as to detect excessive DNA breakdown in cells (Loo, 2011).

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PMC9429973

In a global phase I/II trial (NCT03395210) of heavily pretreated patients with long-standing disease, the Bruton tyrosine kinase inhibitor rilzabrutinib showed a rapid and durable platelet count increase and was well tolerated.

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PMC11574029

Data are presented as the mean ± SEM of three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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PMC8557138

In a follow-up study, it was shown that the invasive cancer cells resulted in phenotypically aggressive tumors that resulted when peptides got embedded and started replicating the natural ECM sites for example the collagen and laminin.

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PMC11188874

Assays were performed in Tris-HCl (20 mmol/L, pH 7.6), 5 mmol/L MgCl2, 2 mmol/L ATP, 1 mmol/L DTT, and 10% glycerol.

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PMC9429973

Moreover, 84.6% of IGLV3-21 cases carried non-stereotyped immunoglobulin genes while the remaining stereotyped IGLV3-21 cases were subset #2.

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PMC11397654

Treatment using the complex was the most effective and significantly improved the survival rate compared to PBS, MTX, and 36 treatments.

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PMC8567602

Similarly, synovial sarcoma tumors demonstrated strong coprecipitation of SMARCB1 with PBRM1 and DPF2 and the reciprocal coprecipitations, albeit with low levels of SMARCB1 present in the input (Fig. 4D and E; Supplementary Fig. S4A and S4B).

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PMC11092418

Effects of tyrosine kinase inhibitors (TKIs) on cell signaling on brain tumor cell line A172 in the presence or absence of ligands.

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PMC7338939

and R(u(t)) are calculated for both IV and IT injections.

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PMC9429973

N. TRABELSI, I. Kraiem, S. Menif, S. Abbes Institut Pasteur de Tunis, Tunis, Tunisia Background: Band 3 is the most abundant transmembrane protein in the erythrocyte, which is encoded by the SLC4A1 gene.

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PMC10538569

Taken together, our results suggest that using GPI-scFv-based MAVIs that can effectively restrict both HIV-1 cis- and trans-infection may be a promising approach to achieve a functional cure for HIV.

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PMC11707832

Investigations extending beyond α-mannosidosis have unveiled notable insights into the potential role of MAN2B1 in inflammatory conditions, particularly in macrophage infection and activation.

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PMC11562028

The cells were then placed under a fluorescence inverted microscope and photographed.

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PMC9143157

Since 2002, a combination of gemcitabine plus docetaxel was widely used as a first-line option for locally advanced or metastatic leiomyosarcoma .

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PMC9429973

Lymphopenia at diagnosis is an additional, inexpensive and easy value to predict relapse or refractory disease in DLBCL with low IPI score.

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PMC9429973

These drugs may allow for use of less chemotherapy and improve remission durations and overall survival (OS) in older pts with newly diagnosed B-ALL.

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PMC11680049

The localization of terpenoids was determined using NADH reagent .

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PMC9429973

This is the first-in-human study of autologous HBG1/2 promoter-modified CD34+ HSPCs (RM-001) in TDT and both patients were treated successfully without SAE.

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PMC6364197

Collagen, a major extracellular matrix (ECM) component, is coated to scaffold to make cell adhere better and as a ligand of DDR1 (11).

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PMC9429973

At baseline, the gender ratio, paraprotein isotype, ISS and R-ISS stage were comparable.

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PMC9429973

Methods: In this monocentric retrospective study, we included consecutive adult patients (≥18 years of age) who were diagnosed with non-M3 AML between 2010 and 2020.

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PMC9429973

The incidence of adverse events was high (75%).

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PMC11521786

Following a five-dose treatment scheme ( Figure 6A ), statistically significant differences in tumor growth were observed between mice treated with Mv-HER3-induced PAbs and those treated with PAbs purified from nonimmunized rabbits (239 mm ± 65.7 mm vs. 568.1 mm ± 187 mm, p < 0.0001) ( Figure 6B ).

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PMC6461034

Edge widths correlate with the associated substrate site “phosphosignal”, and edge colors indicate the analysis on which the kinase–substrate relationship was based (coral: PSP, cornflowerblue: NWK, forestgreen: both).

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PMC11127909

Additionally, treatment with CATR combined with cisplatin increased C-C3 expression in the 143B-EFHD1 group compared to treatment with cisplatin alone.

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PMC11711063

All antibodies used are listed in Table S1.

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PMC11628309

MPP+ exposure increases lysosomal cholesterol levels and stimulates α-synuclein aggregation.

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PMC11699178

P < 0.01, ***P < 0.001 Exploring the molecular mechanisms of Dioscorea nipponica Makino extract on inhibiting the proliferation, migration, invasion capabilities, and angiogenesis of ovarian cancer cells.

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PMC5415764

Similar to the P-gp inhibition results, the level of cytotoxicity among free P+T, P/LPN+T, and P/iRGD LPN+T was comparable.

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PMC11490153

The highest percentages of apoptotic cells were observed in MDA-MB-231 and A-375 cells treated with citral-AlgNPs (84 ± 5%) and C. citratus-AlgNPs (92 ± 5%), respectively.

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PMC8584319

MAPKs are serine/threonine protein kinases that activate multiple cellular signaling pathways such as gene expression and programmed cell death through sequential phosphorylation of different molecules.

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PMC6468656

Moreover, ghrelin was also observed to induce cell migration by triggering the activation of GHSR/CaMKII/AMPK/NFκB signaling pathway in glioma cells .

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PMC11766174

Progress has been made in understanding the molecular pathogenesis of HIV and has since led to the development of combination antiretroviral therapy (cART).

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PMC9429973

Anti-teclistamab Abs were not detected in any pts.

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PMC9412887

The average particle size of ANCs was approximately 30 nm.

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PMC2196094

The nucleotide sequence is deposited in GenBank under the accession number U67914.)

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PMC2196094

The PCR product was loaded on a 1% low melting point agarose gel, and the DNA from a broad band of ∼500 bp in size was isolated and cloned into a plasmid vector.

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PMC10582049

Dendrograms are generated in accordance with hierarchical clustering.

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PMC11723947

With their binding partners, which include the corepressor TRIM28 and the lysine methyltransferases SETDB1 and SUV39H1, they are critically involved in CD4 and CD8 T cell programming in response to activating and polarizing signals.

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PMC11628904

Image showing method of quantification for burn depth.

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PMC11462673

As depicted in Fig. 3B, the fluorescence signal intensity of mice in the LDB1 knockdown group demonstrated a substantial reduction in comparison to the control group.

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PMC9917080

DIO2 is localized in the ER, unlike other types of deiodinases.

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PMC2614416

Five scan events are recorded for each data acquisition cycle.

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PMC11721064

A and B IF staining (A) and quantification of CK12 + cells (B) showed that Stattic treatment significantly decreased the population of CK12 + cells (CK12: p < 0.001) (scale bar = 50 μm).

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PMC8632470

The result obtained in our study is comparable with the previously reported result given by Kwon and coworkers.

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PMC9429973

S. Di Folca, V. Marafioti, S. barbato, S. Avilia, F. Grimaldi, A. Severino, M. Picardi, L. Luciano, G. Battipaglia, F. Pane Ematologia, AOU Federico II, napoli, Italy Background: Combination of carmustine, etoposide, cytarabine, melphalan (BEAM) is a commonly used regimen for autologous stem cell transplantation (auto-...

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PMC10114490

We expanded the life span of HDF by expression of human telomerase reverse transcriptase (hTERT; HDF-T).

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PMC10847511

To our knowledge, there are currently no data on such HR functional assays across multiple cancer cell lines, but such data may shed light on this issue in the future.

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PMC11672881

The RNAseq data and metabolomic pathway analysis provide complementary insights into the effects of thymoquinone (TQ) and curcumin (CU) on A375 cell lines, revealing a comprehensive mechanism of action against melanoma cells.

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PMC11765988

Pathophysiological causation is considered possible by Ishihara et al., but cross-reactivity between Borrelia and other agents suspected to trigger the development of sarcoidosis (molecular mimicry) was not excluded .

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PMC6222635

The C-NMR signals for DWDOP1 and FWDOP1 were also almost the same.

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PMC11285179

These include the hypoxia-inducible factor-1α (HIF-1α) signaling pathway under low oxygen conditions, interaction with vascular endothelial growth factor (VEGF), involvement of anti-inflammatory factors and growth factors, cell–cell interactions, as well as the nuclear factor-κB (NF-κB) signaling pathway and hormonal r...

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PMC11680562

After collection, the samples were assessed using a UV spectrophotometer at 266 nm wavelength to quantify the released drug accurately.

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PMC9429973

Our interpretation on these findings is that JAK2V617F is per se a strong risk factor for unusual venous thrombosis while CALR mutation must be enriched for additional non-driver alterations, needing a second hit to drive to thrombosis.

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PMC10571053

FINs inhibit P-gp and ABCG2 transport activity.

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PMC7723249

Epithelial cells have asymmetric plasma membranes containing distinct apical and basolateral domains with differences in the expression/distribution of cellular proteins (including the viral receptors), which affect viral entry.

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PMC11604015

In 2019, Zhang et al. reported the first human clinical trial involving CD4 CAR-T cells.

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PMC6222635

The FWDOP1 C-NMR spectrum showed signals at δ102.48, 100.11, 78.43, 76.49, 75.00, 73.86, 72.74, 71.40, 69.93, 60.45, 23.17, and 20.53.

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PMC9429973

Non CR or progression at +100 day and early relapse (< 12 months) had a very negative impact on OS (median of 9 months: Non CR/progression p-value < 0.001/ HR 3, 3 (CI 1.9-6); early relapse p-value <0.001/HR 8.7 (CI 4.8-16.4).

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PMC8316344

TFRC was measured by qPCR and IB in Bel-7404 cells with or without TRIB2 knocked out (A) and in SK-Hep1 cells with or without TRIB2 overexpressed (B).

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PMC11703992

Apart from eQTL, we also conducted MR analysis on protein and metabolite level.

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