PMCID string | Sentences string | ner list |
|---|---|---|
PMC9429973 | Methods: Transplant-ineligible patients with NDMM received 28-day cycles of Rd (R 25 mg PO on Days 1-21; d 40 mg PO QW) ± DARA (16 mg/kg IV QW in Cycles 1-2, Q2W in Cycles 3-6, and Q4W thereafter) until disease progression or unacceptable toxicity. | [
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PMC3019555 | We treated parental 1A9 and 1A9/PTX10 cells with TX and assessed the polysome association profile of HIF-1α as described in Fig. 1. | [
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PMC11711345 | A few data of ALDH1A1 to calculate correlation. | [
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PMC9429973 | The overall response rate (ORR) was 87.8%. | [
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PMC10197932 | Lymphocytes were also stained with CD8+ activation marker CD69 Monoclonal Antibody (FN50), PE, eBioscience, CD137 (4-1BB) Monoclonal Antibody (4B4 (4B4-1)), PE, eBioscience™ and its isotype control Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience. | [
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PMC11228511 | Of note, cGAS-mCherry was often found in nuclear blebs (Fig. 6C and Movie S1), suggesting that blebs formed at a NM rupture site. | [
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PMC11755519 | However, exosomes of malignant cell lines were more potent in complement activation than exosomes derived from non-malignant HCV-29 cells. | [
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PMC11335267 | Although no differences in the expression of lipolytic or lipogenic genes were found between Alx3-deficient and control mice fed with SCD, a significant increase in the expression of Pck1 in the adipose tissue of mutant animals was observed. | [
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PMC11314247 | A total of 30 μg of protein was separated via 10% SDS PAGE and transferred onto a polyvinylidene difluoride membrane (cat. | [
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PMC9429973 | H. Fernandez Leyva Haematology, NHS, Licoln, United Kingdom Background: Despite the introduction of robust detection programs into clinical practice, alloimmunisation remains a problem, particularly in the context of increased transfusion requirements and RhD pregnancy-induced alloimmunisation. | [
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PMC11248911 | GROMACS 2020.2 software was used to carry out 100 ns MD simulation for the complexes. | [
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PMC11535726 | In addition, K.bulbosapicalis exhibits cylindrical to ovoid or obclavate conidia with 8–13 septa and often consist of bulbous structures at the apex and/or the third or fourth cell, as well as a spherical hyaline mucilaginous sheath. | [
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PMC11676674 | In Italy, Greece, Spain, and Turkey, various Cistus species are utilized as antispasmodic and anti-inflammatory remedies, as well as for general treatment of various skin conditions . | [
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PMC10840195 | Relative Twist (B), β-catenin (C), GSK3β (D), TCF4 (E), Snail (F), and E-cadherin (G) expression to β-actin presented separately. | [
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PMC10048572 | One can speculate that this approach could be applied for the analysis of primary patient tumor cell culture to obtain information concerning the evolutionary potential of the tumor cells that may be useful for the therapy selection. | [
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PMC11627060 | Further investigation is warranted to determine the optimal treatment strategy. | [
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PMC11247842 | Methods for the meta-analyses were selected to properly account for the multi-breed structure of the GWAS data. | [
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PMC9429973 | Patients with an HCT-CI score ≥ 3 were considered to have a high HCT-CI score. | [
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PMC11190238 | In a recent updated guideline for EMT research, the official academic society for the EMT field, The EMT International Association (TEMTIA), recommended that EMT status cannot be assessed based solely on one or a small number of molecular markers and these molecular markers together with EMT driving transcription facto... | [
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PMC11612794 | Middle: The transparent surface model of Mis12C, except for the basic motif of Dsn1, is overlaid on a cartoon model. | [
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PMC9429973 | The proportion of patients who used tocilizumab and corticosteroids for CRS were 35.57% (p<0.001) and 12.69% (p<0.01) lower, respectively, in patients infused with tisa-cel (Figure 1C). | [
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PMC10040136 | After 21 days of continuous culture, differentiated MSC cells are ready for assay. | [
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PMC9429973 | Aims: To understand the key factors affecting BT HSC function it is essential to gain novel insight into BT pathophysiology. | [
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PMC11188874 | The cells are rank ordered according to their MHC-I presentation. | [
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PMC11791264 | Each bar represents the mean ± SD (n = 3). | [
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PMC9429973 | A high rate of major complications, mainly infectious, was observed after treatment with ATG. | [
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PMC5925824 | Luminescence was measured in a plate reader and data was analyzed using GraphPad Prism software . | [
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PMC10545062 | Our refined algorithm, SCC+, improved upon its predecessor by layering additional physiologic inputs to closely approximate clinical inputs that are commonly used to guide resuscitation, as well as the addition of vasopressin to augment NE titration. | [
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PMC7351993 | f Theoretical estimation of the throughput-purity relation at various flow speed values together with our experimental verification (orange dots). | [
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PMC11612794 | CENP-T is shown as a cartoon and models are color-coded as indicated in the figure. | [
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PMC6379402 | The Barabàsi–Albert scale-free model (SF). | [
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PMC9611901 | Elastin is found in the papillary layer and is removed when the leather is processed. | [
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PMC11644761 | These results suggest that pterostilbene may offer neuroprotective advantages for differentiated neuronal-like cells. | [
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PMC8922418 | Currently, the primary treatment for HIV-1/AIDS is combined antiretroviral therapy (cART), which is a combination of multiple drugs that effectively inhibit the functions of various viral proteins during HIV-1 replication. | [
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PMC5925824 | The highlighted circles correspond to differentially expressed genes (DEG) or cytokines that display fold change > 1.7 (black solid vertical line) and p value < 0.05 (horizontal dotted line). | [
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PMC9964635 | HNMR (500 MHz, DMSO) δ 10.27 (s, 1H), 7.54 (d, 2H, J = 10.0 Hz), 7.32–7.29 (t, 2H, J = 5.0 & 10.0 Hz), 7.10–7.02 (m, 5H), 4.31–4.29 (q, 1H), 4.01 (s, 2H), 3.29 (s, 3H), 2.39(d, 2H, J = 5.0 Hz), 1.79–1.76 (m, 1H), 1.59 (d, J = 5.0 Hz, 3H), 0.85 (d, J = 10.0 Hz, 6H). | [
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PMC9429973 | Overall, 11 patients (22%) developed GVHD after DLIs. | [
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PMC11545737 | Infections with Y. pseudotuberculosis and Y. enterocolitica are widespread throughout the world, both causing gastroenteritis, while Y. pseudotuberculosis can also cause mesenteric lymphadenitis . | [
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PMC9599726 | Cells were washed with BD Perm/Wash buffer (1x), pelleted, resuspended in PBS/FBS 2%, and analyzed by flow cytometry. | [
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PMC2191123 | This cDNA corresponds to the transcript of the tyrosinase gene. | [
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PMC9822769 | Depending on its direction (along or against the electrochemical gradient), carrier-mediated transport can be passive or active, with the latter transport dependent on the ATP or ion gradient. | [
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PMC11697703 | See also Figure S1. | [
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PMC11621565 | The blots were cut prior to hybridisation with antibodies due to technical reasons to ensure they fit the incubation boxes. | [
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PMC7053076 | In the HL-60/5FU cells, relative RelA, RelB, NF-κB1, NF-κB2 and c-Rel mRNA expression levels were 1.1–4.4-fold higher than in the parental HL-60 cells (Table 2). | [
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PMC9429973 | AE mitigation strategies include prophylactic and symptomatic use of anti-nausea/vomiting and anti-diarrheal Tx, thiamine supplementation, FEDR dosing modifications, and administration of FEDR with food. | [
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PMC11549062 | Statistical analysis was performed using GraphPad Prism version 9.00 software (GraphPad). | [
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PMC11013014 | In fact, microsomal glutathione transferase 1 (mGST1) and glutathione transferase pi (GSTpi) are often overexpressed in tumour cells and confer resistance against a number of cytostatic drugs, such as cisplatin and doxorubicin (DOX) . | [
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PMC11748363 | To measure the viability CellTiter 96 AQueous One Solution Cell Proliferation Assay (CellTiter 96; PROMEGA, Fitchburg, USA) was used, and the results were expressed as inhibitory concentration which reduces viability of the cell population to 50% from the maximum viability (IC50) and calculated by nonlinear regression ... | [
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PMC11741906 | To evaluate the clinical significance of the identified miRNAs in ovarian cancer patients, survival analyses were performed using data for patients diagnosed with ovarian cancer available in the KMplot database . | [
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PMC10114490 | In conclusion, implementation of polycistronic inducible vectors in iHEP reprogramming requires a fibroblast cell line resistant to senescence without neoplastic transformation. | [
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PMC11763126 | Similarly, Wang et al. conducted peptidomics on serum samples from ovarian cancer patients and identified the significantly downregulated ZYX36-58 peptide, which demonstrated the ability to inhibit the invasion and migration of ovarian cancer cells . | [
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PMC11188874 | The mass spectrometer was operated using a custom data-dependent method, with mass spectrometry (MS) performed in the Orbitrap at 60,000 FWHM resolution and sequential MS-MS performed using high-resolution CID and EThcD in the Orbitrap at 15,000 FWHM resolution. | [
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PMC10142392 | When cabazitaxel was loaded into the micelles, a drug content of 14.4% and an encapsulation efficiency of 85% were obtained. | [
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PMC11116779 | The graph represents the mean percentage ± SD of four experiments. | [
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PMC10165258 | Subsequent systematic imaging and image analysis resulted in relevant time-dependent viability information. | [
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PMC9895440 | Minimally 415’000 (most samples 600’000) T cells were sorted into cold FACS buffer, then centrifuged at 500 g for 8 min, and washed by centrifugation with cold PBS. | [
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PMC11686380 | Mice embryos were harvested by cesarean section and anesthetized on ice directly for 5 to 10 min to block nerve conduction and reduce pain. | [
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PMC10577955 | The molecular mechanism underlying anti-apoptotic effects was determined by analyzing Let-7 miRNA and miRNA-21 expression, the mRNA gene expression level of Bax, CASP-8, CD95, Bcl2, KRAS, VEGF, Cyclin D1 using qRT-PCR. | [
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PMC11698348 | Cells were harvested 48-hours post-transfection and used for further analyses. | [
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PMC9429973 | Among the causes of death, the most common were lymphoma progression (46%) and severe COVID-19 (47%). | [
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PMC3995603 | The mice were divided into untreated (normal; 200 μL of 70% EtOH/mouse/day), D. farinae-sensitized (control; 70% EtOH), D. farinae-sensitized plus Protopic® ointment-treated (Protopic; 50 mg/mouse/day) and D. farinae-sensitized plus AC extract-treated (AC; 10 mg/mouse/day) groups. | [
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PMC9429973 | According to receiver operating characteristic (ROC) curve analysis, the cut-off value of the model was 0.921 (0.851-0.968,P<0.001). | [
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PMC8336407 | However, when extract was applied in a higher (2.5 mg/mL) concentration, the effect was partially suppressed. | [
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PMC11267830 | c Comparison of fluorescence values between the two groups of mice, which served as an indicator of the extent of leukemia burden in the mice. | [
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PMC11583690 | ∗, ∗∗, and ∗∗∗ indicate p < 0.05, <0.01, and <0.001, respectively (Student t-test).Fig. | [
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PMC11694109 | The approach allows for a detailed analysis of T-cell phenotypes with a relatively limited analysis of additional subsets including B cells, macrophages, and dendritic cells. | [
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PMC11697189 | The pRRophetic R package was applied to explore the drug response in different risk groups. | [
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PMC10914904 | RIG-I and MDA5 can trigger the nuclear translocation of transcription factors such as interferon regulatory factor 3 (IRF3), IRF7, and nuclear factor-kB (NF-kB). | [
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PMC9024365 | The quantification of mean area of clusters shows an increase in puncta size when SD4 is co-expressed with GluA1, but no significant difference when co-expressed with the chimera expressing the M1-3, S2, M4, and CT domains of GluA1 (Figure 3G). | [
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PMC11756907 | Graphene nanoflakes constitute a carrier platform with unique biological and biophysical properties, which enable the regulated and selective distribution of the associated chemotherapeutic agent, thus increasing the effectiveness of treatment and minimising the side effects. | [
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PMC8633974 | In aggregate, we conclude that the high efficacy of TatDE CRISPR-Cas9 therapy against numerous HIV-1 strains results from disrupting five viral exons simultaneously. | [
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PMC10253973 | Karaoun et al. prepared Ru(II) complexes with econazole for use as a cell marker and factor in PACT. | [
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PMC11803918 | +) means light irradiation, Xe lamp, 650 nm, 6.4 mW/cm, 12 min. | [
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PMC11673902 | Many studies have shown that acoustic-based cell sorting has great potential for maintaining cell viability, high purity, and high recovery . | [
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PMC11738017 | Physicians should claim only the credit commensurate with the extent of their participation in the activity. | [
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PMC10854447 | Found: C, 62.67; H, 4.89; N, 19.51. | [
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PMC11371747 | Previously we also observed in patients that 5FU induced increased TS protein and enzyme activity levels, but not TS mRNA, while LV treatment prevented the increase in TS levels (Peters et al., 2002). | [
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PMC11218145 | As shown in Fig. 5, the addition of FOH, but not GGOH, completely abolished the cytotoxic effects of TB, significantly restoring the viability of the tested cell lines. | [
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PMC9220170 | Thus, SELENOM-KD and SELENOT-KD, in the absence of external stimuli on A-172 human glioblastoma cells, did not affect the proliferative activity of cells, their transformation into normal cells, migration, and the formation of cell colonies. | [
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PMC11802929 | Exhaustion: TIGIT, PDCD1. | [
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PMC11266100 | Murine 4T1 (ATCC-CRL-2539), a mammary gland tumor cell line of BALB/c origin and Chinese Hamster Ovary CHO-K1 (ATCC-CCL-61) cell lines were grown in RPMI 1640 medium supplemented with glutamine, 100 U/mL of penicillin, 100 mg/mL of streptomycin, and 10% of fetal bovine serum (FBS). | [
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PMC11772585 | Our findings highlight the significant role of ATF4 in preventing mitochondrial depolarization and decreasing mitochondrial mass, as demonstrated by JC-1 and mitoTraker assays in cSCC cells lacking METTL1. | [
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PMC7823217 | Evolution of cell-culture models from simple 2D to complex 3D bio-printed models. | [
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PMC9250505 | Importantly, the synergism between NPB and PARP inhibition was independent of BRCA, P53, PI3K, PTEN, or RAS mutational status. | [
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PMC5415764 | Our study aimed to demonstrate that the targeted LPN system delivering a combination of an anticancer drug and P-gp inhibitor in a temporal drug release manner could effectively overcome tumor drug resistance. | [
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PMC11063646 | The absence of any significant changes in these peak values suggests that there is no chemical interaction occurring during the formulation process, as depicted in Table 3 and Fig. 1.Table 3IR stretching values of specific functional groups. | [
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PMC9429973 | M. K. Leabman, G. Hernandez, C. M. Ng, J. Tang, D. Pandya, K. C. Hart, K. Li, P. R. Hinton, J. So, I. Qazi, C. Y. Cheah, W. S. Kim, E. Budde, A. K. Gopal, T. Manley, C. H. Takimoto, A. M. Sinclair, S. F. Carroll, B. A. Keyt, M. F. Kotturi IGM Biosciences, Inc., Mountain View, United States of America; Linear Clinical R... | [
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11422150 | The therapeutic effects of stem cells are attributed to their pleiotropic, anti-inflammatory, and neurotrophic effects (Lovell-Badge, 2001; Dang et al., 2015). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC9429973 | By incorporating index-event procalcitonin levels with the score, the discriminatory capacity for severe infection events was improved. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"By",
"incorporating",
"index-event",
"procal... |
PMC11453018 | Subsequent comparison between the two approaches revealed significant overlaps of approximately one-fourth of the differentially expressed genes (DEGs), indicating a shared transcriptional response to both EWS-FLI1 knockdown and iP300w treatment (Fig. 3D). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11377827 | To understand how USP43 may facilitate a HIF-1 transcriptional response, we examined if USP43 associated with HIF-1α in hypoxia by incubating HeLa cells in 21 or 1% oxygen for 6 h and immunoprecipitating endogenous USP43 or HIF-1α. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
... |
PMC11342785 | Scale bars represent 10 μm. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Scale",
"bars",
"represent",
"10",
"μm",
"."
]
}
] |
PMC9429973 | Therapeutically: Treatment based on immuno-chemotherapy with RCHOP (Rituximab- Cyclophosphamide- Doxorubicin- Oncovin- Prednisone) was the most used in first line (73% of cases), with an eradication treatment of Hp in 74% of cases, 10 patients required intensification by autograft, 21patients Were operated, and radioth... | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC9429973 | Due to infection developing, broad-spectrum antibiotics were prescribed. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Due",
"to",
"infection",
"developing",
",",
"broad-spectrum",
"antibiotics",
"were",
"prescribed",
"."
... |
PMC11351758 | The human mtDNA is a double-membrane circular molecule of 16,569 bp and it critically encodes 13 polypeptides of the mitochondrial respiratory chain for oxidative phosphorylation, 22 tRNAs, and two small and large subunits of rRNA for protein synthesis. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC9817179 | COPASI numerically simulates the four states in the kinetic model utilizing the starting concentrations and rate conditions. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"COPASI",
"numerically",
"simulates",
"the",
"four... |
PMC11026382 | Control coefficients vary with starting enzyme velocity (purple and dark blue arrows, background A) and can change with genetic background (violet and light blue arrows, background B). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11733919 | Indeed, the activation of NF-κB upon 24 h of stimulation with 30 μg/mL MNP@CD26@17D was also observed in senescent skin cancer cells that were accompanied by ferroptosis induction (this study). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11732635 | The vital signs, routine blood measures, and cytokine levels were consistently monitored. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"vital",
"signs",
",",
"routine",
"blood",
"measures",
","... |
PMC9429973 | Patients with a poor prognosis also showed a higher thrombin-peak (352.9 vs 310.6 nM; P=0.038), with an even more notable difference in the presence of thrombomodulin (308.6 vs 197.9 nM; P=0.006). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
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