OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11803918	Human melanoma cells A375 were seeded in a six-well plate (800 cells per well) and treated with Vγδ-T exosomes, hybrid exosomes, or Ce6-loaded liposomes with or without light irradiation (Xe lamp, 650 nm, 6.4 mW/cm, 12 min).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11768281	Ganley et al. proposed mRNA-based vaccines as a promising solution, as they can enable the expression of both whole genes and proteins, potentially offering a wide array of epitopes and increased population coverage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742864	While immunotherapy and targeted therapies have dramatically improved lung cancer treatment, the five 5-year survival rates are still unsatisfied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "immunotherapy", "an...
PMC3765139	Two genes were outstandingly upregulated, i.e., matrix GIa protein (MGP) and prominin 1 (PROM1, CD133).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "genes...
PMC9429973	P. Richter-Pechanska, J. Kunz, T. Rausch, B. Erarslan-Uysal, B. Bornhauser, V. Frismantas, Y. Assenov, M. Zimmermann, M. Happich, C. von Knebel-Doeberitz, N. von Neuhoff, R. Koehler, M. Stanulla, M. Schrappe, G. Cario, G. Escherich, R. Kischner-Schwabe, C. Eckert, S. Avigad, S. Pfister, M. Muckenthaler, J.-P. Bourquin,...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253553	The phosphoinositide 3 kinase (PI3K)/AKT/mechanistic Target Of Rapamycin (mTOR) pathway promotes cell growth, cell survival, proliferation, and tumor growth .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	This study has implications for the development of therapies targeting downstream effectors of NF-kB–mediated survival pathway to overcome treatment failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "stud...
PMC11349530	Many tumor-produced factors are cytokines, but not all of them - for example, adenosine and kynurenines are not usually considered cytokines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", ...
PMC7504302	In conclusion, this study showed that RNAi screens could be harnessed for the functional interrogation of genes on a large scale and help uncover new genes and signaling pathways with therapeutic implications in MPM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The secondary endpoint was complete response ratio (CR) and adverse events (AE).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "secondary", "endpoint", "was", "complete", "res...
PMC9878278	In selected experiments, cells were treated with different recombinant proteins or dsRNA mimic poly I:C (InvivoGen) 24 h before infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9220170	According to the real-time PCR results shown in Figure 5b, expression levels of the ATF-4, XBP1s, and ATF-6 did not change significantly during SELENOM-KD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8708099	no. 555244).	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "no.", "555244", ")", "." ] } ]
PMC11767582	Finally, analogue 3r, that shares substitution pattern on the B-ring with the reference natural product CA-4, was previously described to have an IC50 of 35 nM for the leukemia cancer cell line K562 (Figure 2, R = H, R = OH) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6617630	Several studies have shown the role of BCL-2 in cancer cell survival and drug resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "studies", "have", "shown", "the", "role", "of", ...
PMC11730320	The cells next undergo positive and negative selection, where interaction with peptide-MHC complexes triggers the enrichment of those that are potentially reactive to foreign antigens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11799978	Supernatants were collected and protein concentrations were measured using bicinchoninic acid (BCA assay, Epizyme).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supernatants", "were", "collected", "and", "prote...
PMC9429973	Aims: We conducted a phase 2 study with DVd regimen in patients with MM who received 1 prior line of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...
PMC9429973	Further data will be presented at the meeting including results of multivariate analysis to identify baseline patient factors that correlate with PFS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "d...
PMC2614415	Two proteins known to bind and initiate activation of Aurora-A are TPX2 and Ajuba .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "proteins", "known", "to", "bind", "and", "initiate", "act...
PMC4839679	The upregulated genes were involved in biological processes like cell adhesion (GO:0007155; GO:0007157; GO:0022409) and actin cytoskeleton organization (GO:0030036) indicating a unique role for PBRM1 in the expression of these genes that is not redundant with other tumor suppressor genes commonly mutated in ccRCC (Fig ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9918897	The XN content of the original beer was measured at the University of Chemistry and Technology in Prague.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "XN", "content", "of", "the", ...
PMC3888431	Different assembly methods were applied to construct transcript sequences from the reads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "assembly", "methods", "were", "applied", "to", "construct", "transcript",...
PMC11656657	Additionally, we assessed GM-CSF and IFNγ levels as positive controls (Supplemental Fig. 12D-E).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "we", "assessed", "GM-CSF", "and", "IFN...
PMC11472569	The TMDs provide the specificity for the substrate and the NBDs transfer energy to transport the substrate across the membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TMDs", "provide", ...
PMC10975211	Buforin IIb is a histone-H2A-derived synthetic analog of buforin II that contains an α-helical sequence (3xRLLR) and is altered to improve its selectivity for cancer cells leading to cell death without disrupting the normal cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11577421	Results were considered statistically significant if p < 0.05, with p < 0.05, p < 0.01, p < 0.001, and ** p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9024365	All GluK2/GluA1 chimeras lacked the NT domain of GluA1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "GluK2/GluA1", "chimeras", "lacked", "the", "NT", "domain", "of", "GluA1", "." ] } ]
PMC9684669	These findings suggest that inhibiting CAMK2 could resensitize MDR cells to doxorubicin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "inhibiting", "CAMK2", "could", "resensitize", ...
PMC11467800	In the context of CML pathogenesis, several reports state an increase in angiogenic factors in CML patients that correlate with disease progression; and report that leukaemic cells can stimulate endothelial proliferation and neovascularization in the bone marrow of patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8068766	Heatmaply package (Galili et al., 2017) in R-Bioconductor was used to draw the heat maps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmaply", "package", "(", "Galili", ...
PMC11695623	Although multimodal therapy strategies including targeted therapy, immunotherapy, radiotherapy and non-invasive surgical resection have made great progress in recent decades, the five-year overall survival rate (OS) of lung adenocarcinoma is still about 18%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	Some of the DE TFs upregulated in Mes-like GC (FOXA1, KLF5, etc.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "of", "the", "DE", "TFs", "upregulated", ...
PMC11718109	Scale bars, 10 μm; inset: 2.5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "10", "μm", ";", "inset", ":", "2.5", "μm", "." ] } ]
PMC10495912	It should be noted that cytotoxicity was measured as the concentration that inhibits the growth of 50% of cells (IC50).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC11025866	HH514-16 human Burkitt lymphoma cells were cultured in RPMI 1640 + glutamine supplemented with 8% FBS, penicillin (50 U/mL), streptomycin (50 U/mL), and amphotericin B (1 μg/mL).	[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11756907	The selective anticancer effect of the designed complexes is a promising solution for innovative oncological therapies for skin cancer in epidermal or subcutaneous administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9014716	(Bar plot): The differential expressions of 5 screened miRNAs (arranging from high level to low level). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "(", "Bar", "plot"...
PMC11547972	The Western blot data did not show homogenous additive or synergistic effects in regard to nearly all investigated cell cycle and apoptosis related proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11711345	Reviews on the in vitro cytotoxicity of p-cymene are found in the literature but include the ruthenium complexes of this compound .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reviews", "on", "...
PMC9516447	For example, while the inhibitors decreased HRAS and NRAS protein levels in A427, H460, and HCT116 cells, only modest effects were observed for LS180, PANC-1, and CFPAC-1 cells (Supp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O"...
PMC10878518	The high type of benign group showed almost similar expression levels of CAR and hTERT with the low type of intermediate and malignant group (Fig 5A and 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11122631	Additionally, most of the predicted Log Kp values for skin permeation of compounds were located in a similar range (−6.55 to −5.26), but only one predicted Log Kp value of compound 1 was −7.04.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470381	Optional: Gamma adjustment can be performed to control brightness and contrast of the images to aid the intensity thresholding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Optional", ":", "Gamma", ...
PMC11714165	Importantly, DN‐F nanoparticles also suppress bone destruction in an osteosarcoma model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "DN‐F", "nanoparticles", "also", "suppress", "bone", "destruction",...
PMC11696576	Two or three samples were each measured in technical triplicates to give the final % recovery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "or", "three", "samples", "were", "each", ...
PMC11727907	In addition, the metabolic changes induced by IGF-1 appear to be modulated by Klotho.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", "metabolic", "changes", "induc...
PMC11745600	All male and female homozygous mice exhibited persistent severe hyperglycemia associated with β-cell depletion as early as 4 wk of age and exhibited normal insulin sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	TANITA-SC-240MA device was used to measure body composition by BIA method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TANITA-SC-240MA", "device", "was", "used", "to", "measure", "body", "composition", "by", ...
PMC10823017	This type of cancer stems from the cell lining of the small tubules that usually have either a genetic mutation of a hereditary VHL (Von Hippel-Lindau) or a sporadic mutation in other genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757131	Regarding de novo fatty acid synthesis, the addition of 3-HIB did not affect the expression levels of the key proteins involved in this process, DGAT and ACC, relative to the control group (p > 0.05) (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638288	The extracellular region contains residues 22 to 258 and is characterized by two cysteine-bridged Ig-like N-terminal C2-type domains called D1 (distal membrane domain) and D2 (proximal membrane domain), which span residues 1–94 and 101–188, respectively, and are arranged at an 85° angle to each other.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367146	September 25, 2023) was deposited to the herbarium of SOA University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "September", "25", ",", "2023", ")", "was", "deposited", "to", "the", ...
PMC9429973	Six of 8 (75%) Ph- pts responded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Six", "of", "8", "(", "75", "%", ")", "Ph-", "pts", "responded", "." ] } ]
PMC11727145	The scanner microscope Olympus VS200 (Olympus Corporation, Tokyo, Japan) was used to perform imaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scanner", "microscope", "Olympus", ...
PMC9429973	Characteristics of 639 NGS-annotated SMF.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Characteristics", "of", "639", "NGS-annotated", "SMF", "." ] } ]
PMC7090062	In addition, EdU analysis indicated that miR-30a overexpression significantly suppressed the proliferation of IM treated GIST-882/GIST-T1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "addition", ",", "EdU", ...
PMC11240571	When the tumors had grown to about 5 mm in diameter, the mice were irradiated with 12 Gy, and exosomes were isolated from the blood of each mouse 1 to 5 days after irradiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10761571	Finally, the DLS size and zeta-potential of Fe3O4@Glu-Gingerol were determined by a HORIBA Scientific SZ-100 Zeta sizer (Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "t...
PMC2193049	After a 24-h incubation at 37°C, supernatants were collected and the TNF-α content was determined in a functional assay using WEHI-164 clone 13 cells (22) as described (23).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11512230	Ewing sarcoma (ES) is an aggressive tumor of mesenchymal origin that accounts for 10% to 15% of all bone sarcomas, according to various data and classifications .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10490530	Further, the assay developed is compatible with the standard set of luminescence measurement equipment available and, therefore, can be widely used for many suitable applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We confirmed the reliability prognostic efficacy of NLR and LMR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "confirmed", "the", "reliability", "prognostic", "efficacy", "of", "NLR", "and", "LMR", ...
PMC9424261	Representative images of IB are shown in the figure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "IB", "are", "shown", "in", "the", "figure", "." ] } ]
PMC11742431	In contrast, A375, a PD‐L1 negative cell, had no pro‐apoptotic capacity with KVN and K14N treatment.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "A...
PMC11525028	ASNS is the enzyme responsible for Asn biosynthesis (Figure 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ASNS", "is", "the", "enzyme", "responsible", "for", "Asn", "biosynthesis", "(", ...
PMC7709199	The model was refined to an R factor of 0.189 and an R free of 0.217, and its stereochemistry was validated using the MolProbity web service (Chen et al., 2010 ▸), indicating that there were no residues in the disallowed regions of the Ramachandran plot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Intravenous injection of adeno-associated virus (AAV)-TBG-Mecp2 (Greig et al., 2018) reinforced the levels of Mecp2 in hepatocytes compared to empty vector (EV) control cells (Figure 2E and F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10878518	The expression levels of CAR and hTERT in the malignant and intermediate group and the benign group were evaluated using the ATM, as reported previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9910796	The possible protein topology was predicted using TMHMM 2.0 at https://services.healthtech.dtu.dk/service.php?TMHMM-2.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "possible", "protein", "topology", "was", "predicted", "using", "TMHMM", "2.0", ...
PMC9429973	The effect on apoptosis was quantified by AnnexinV/7-AAD staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "on", "apoptosis", "was", "quantified", "by", "AnnexinV/7-AAD", "staining", "." ] } ]
PMC9581083	In vitro cellular assays and in vivo animal studies are required to confirm these predicted mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vitro", "cellular", "assays", "and", "in", ...
PMC9920575	In both pathways, apoptosis is carried out by caspases (cysteine aspartyl-specific proteases), which can function as initiators or executors that cleave target proteins, eventually leading to the death of the cell .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7685376	Short interfering RNAs (siRNAs) were synthesized by GenePharma (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Short", "interfering", "RNAs", "(", "siRNAs", ")", "were", ...
PMC11674146	Genetic mutations have been shown to partly activate inflammatory pathways and modulate the upstream or downstream targets of pathways in lymphoma (Shi et al., 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The majority of the patients had limited or intermediate stage of disease: Ann Arbor stage I/II 51.4%, stage III/IV 48.6%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11745823	In the current diagnostic categories of gliomas, there are usually some landmark molecular markers: 1p/19q coding deletion, mutation and MGMT promoter methylation, among others.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756514	Neoglycoproteins were obtained from Dextra: fucose-BSA (Fuc-BSA) (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neoglycoproteins", "were", "obtained", "from", "Dextra", ":", "fucose-BSA", "(", ...
PMC11634027	Both Ds-210 and Ds-150 intensities are included in the quantification. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "Ds-210", "and", "Ds-150", "intensities", "are", "included", "in", "the", "qua...
PMC6650823	Molecular hybridization is an approach in rational drug design where new chemical entities are obtained by combining two or more pharmacophoric moieties into a single molecule .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11271278	These results indicate that the enhancers involved in hijacking are already active in cancer cells without the translocation and are cancer-type specific.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "res...
PMC9429973	Grade ≥3 treatment-related AEs occurred in 2 (7%) patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grade", "≥3", "treatment-related", "AEs", "occurred", "in", "2", "(", "7", ...
PMC9429973	Image: Summary/Conclusion: This is the first NMA to compare the efficacy of zanubrutinib with all commonly utilized first-line treatment for TN CLL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11335267	p < 0.05, p < 0.01 and *p < 0.001, two-way ANOVA (A, C and E-N) or Student’s t-test (B, P-Q) Altered response of Alx3-deficient mice to feeding with a high fat diet A) Body weight curves of Alx3-deficient and wild type mice fed with standard chow (SCD) or high-fat (HFD) diets (8–10 animals per group).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476222	In-depth ganglioside isomer characterization is useful in many applications; however, it does require additional instrumentation, analysis time, and sample preparation compared to our method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8984067	Then, 2 mg anti-EpCAM-UCNPs-Ce6 was added to 5 mL ethanol and dispersed uniformly via ultrasonication to form the solution of nanoparticles, and its absorbance at 404 nm was determined through UV-Vis spectrophotometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	For this purpose, we generated a TRAF7-KO cell line from NIH3T3 cells using the CRISPR-Cas9 genome editing (Fig. 4g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	After the first treatment cycle, 93% of evaluable pts (14/15) had <1% of multiple myeloma cells in bone marrow based on flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11593084	Furthermore, the recognition mode of H2Mab-214 was solved by X-ray crystallography .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "recognition", "mode", "of", "H2Mab-214", "was", "solv...
PMC7802142	However, no change was seen upon treatment with 293-NV when compared to PBS (Fig. 3c, d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "no", "...
PMC9917080	, fetal bovine serum (10099141); Selenum nanoparticles and sorafenib-doped selenium nanoparticles (SeSo) (courtesy of Dr. SV Gudkov, Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9119314	The controls were included for the background fluorescence (0% viability; parasites exposed to a supralethal 10 μM chloroquine concentration) and 100% growth (parasites in drug-free wells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741906	Previous studies identified cisplatin as an activator of MAPK pathway in many cancer cells, but this stimulation either prevents or interferes with the induction of cisplatin-induced apoptosis , which makes the role of this pathway needs further studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Keratinocytes transfected with ALOX15B siRNA for 72 h alone (A–D) or followed by 30 min pre-treatment with 2 µM PD168393 or vehicle (DMSO), then combined with cocktail treatment of 50 ng/ml IL-17A, TNFα and 10 ng/ml IFNγ for 30 min (E, F) or IFNγ alone or 6 h (F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7081114	The Kaplan-Meier method was used to assess prognosis significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Kaplan-Meier", "method", "was", "used", "to", "assess", "prognosis", "significance", "." ] } ]
PMC9429973	CR rate in patient with CK was 60%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CR", "rate", "in", "patient", "with", "CK", "was", "60", "%", "." ] } ]
PMC11686380	pCAG-Myc-GAP43 or pCAG-Myc-GAP43R (0.2 µg each) was co-transfected into COS7 cells with pSuper-shLuc (Control) or pSuper-mGAP43#1 (1.5 µg each).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11650848	The mQTL rs2747429 resides 21 base pairs downstream from our mQTL (rs365052) and has already been recognised as a mQTL in brain and T-cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC2777936	Results presented are an average of duplicate readings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "presented", "are", "an", "average", "of", "duplicate", "readings", "." ] } ]
PMC11726183	TOF HRMS (m/z): [M + H], calcd: 357.1315, found: 357.1315. %	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TOF", "HRMS", "(", "m/z", "...

PMC11803918

Human melanoma cells A375 were seeded in a six-well plate (800 cells per well) and treated with Vγδ-T exosomes, hybrid exosomes, or Ce6-loaded liposomes with or without light irradiation (Xe lamp, 650 nm, 6.4 mW/cm, 12 min).

[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11768281

Ganley et al. proposed mRNA-based vaccines as a promising solution, as they can enable the expression of both whole genes and proteins, potentially offering a wide array of epitopes and increased population coverage .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742864

While immunotherapy and targeted therapies have dramatically improved lung cancer treatment, the five 5-year survival rates are still unsatisfied.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "immunotherapy", "an...

PMC3765139

Two genes were outstandingly upregulated, i.e., matrix GIa protein (MGP) and prominin 1 (PROM1, CD133).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "genes...

PMC9429973

P. Richter-Pechanska, J. Kunz, T. Rausch, B. Erarslan-Uysal, B. Bornhauser, V. Frismantas, Y. Assenov, M. Zimmermann, M. Happich, C. von Knebel-Doeberitz, N. von Neuhoff, R. Koehler, M. Stanulla, M. Schrappe, G. Cario, G. Escherich, R. Kischner-Schwabe, C. Eckert, S. Avigad, S. Pfister, M. Muckenthaler, J.-P. Bourquin,...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10253553

The phosphoinositide 3 kinase (PI3K)/AKT/mechanistic Target Of Rapamycin (mTOR) pathway promotes cell growth, cell survival, proliferation, and tumor growth .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

This study has implications for the development of therapies targeting downstream effectors of NF-kB–mediated survival pathway to overcome treatment failure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "stud...

PMC11349530

Many tumor-produced factors are cytokines, but not all of them - for example, adenosine and kynurenines are not usually considered cytokines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", ...

PMC7504302

In conclusion, this study showed that RNAi screens could be harnessed for the functional interrogation of genes on a large scale and help uncover new genes and signaling pathways with therapeutic implications in MPM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The secondary endpoint was complete response ratio (CR) and adverse events (AE).

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PMC9878278

In selected experiments, cells were treated with different recombinant proteins or dsRNA mimic poly I:C (InvivoGen) 24 h before infection.

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PMC9220170

According to the real-time PCR results shown in Figure 5b, expression levels of the ATF-4, XBP1s, and ATF-6 did not change significantly during SELENOM-KD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8708099

no. 555244).

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "no.", "555244", ")", "." ] } ]

PMC11767582

Finally, analogue 3r, that shares substitution pattern on the B-ring with the reference natural product CA-4, was previously described to have an IC50 of 35 nM for the leukemia cancer cell line K562 (Figure 2, R = H, R = OH) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6617630

Several studies have shown the role of BCL-2 in cancer cell survival and drug resistance .

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PMC11730320

The cells next undergo positive and negative selection, where interaction with peptide-MHC complexes triggers the enrichment of those that are potentially reactive to foreign antigens.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11799978

Supernatants were collected and protein concentrations were measured using bicinchoninic acid (BCA assay, Epizyme).

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PMC9429973

Aims: We conducted a phase 2 study with DVd regimen in patients with MM who received 1 prior line of therapy.

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PMC9429973

Further data will be presented at the meeting including results of multivariate analysis to identify baseline patient factors that correlate with PFS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "d...

PMC2614415

Two proteins known to bind and initiate activation of Aurora-A are TPX2 and Ajuba .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "proteins", "known", "to", "bind", "and", "initiate", "act...

PMC4839679

The upregulated genes were involved in biological processes like cell adhesion (GO:0007155; GO:0007157; GO:0022409) and actin cytoskeleton organization (GO:0030036) indicating a unique role for PBRM1 in the expression of these genes that is not redundant with other tumor suppressor genes commonly mutated in ccRCC (Fig ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9918897

The XN content of the original beer was measured at the University of Chemistry and Technology in Prague.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "XN", "content", "of", "the", ...

PMC3888431

Different assembly methods were applied to construct transcript sequences from the reads.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "assembly", "methods", "were", "applied", "to", "construct", "transcript",...

PMC11656657

Additionally, we assessed GM-CSF and IFNγ levels as positive controls (Supplemental Fig. 12D-E).Fig.

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PMC11472569

The TMDs provide the specificity for the substrate and the NBDs transfer energy to transport the substrate across the membrane.

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PMC10975211

Buforin IIb is a histone-H2A-derived synthetic analog of buforin II that contains an α-helical sequence (3xRLLR) and is altered to improve its selectivity for cancer cells leading to cell death without disrupting the normal cells .

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PMC11577421

Results were considered statistically significant if p < 0.05, with *p < 0.05, **p < 0.01, ***p < 0.001, and **** p < 0.0001.

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PMC9024365

All GluK2/GluA1 chimeras lacked the NT domain of GluA1.

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PMC9684669

These findings suggest that inhibiting CAMK2 could resensitize MDR cells to doxorubicin.

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PMC11467800

In the context of CML pathogenesis, several reports state an increase in angiogenic factors in CML patients that correlate with disease progression; and report that leukaemic cells can stimulate endothelial proliferation and neovascularization in the bone marrow of patients.

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PMC8068766

Heatmaply package (Galili et al., 2017) in R-Bioconductor was used to draw the heat maps.

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PMC11695623

Although multimodal therapy strategies including targeted therapy, immunotherapy, radiotherapy and non-invasive surgical resection have made great progress in recent decades, the five-year overall survival rate (OS) of lung adenocarcinoma is still about 18%.

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PMC11216402

Some of the DE TFs upregulated in Mes-like GC (FOXA1, KLF5, etc.)

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PMC11718109

Scale bars, 10 μm; inset: 2.5 μm.

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PMC10495912

It should be noted that cytotoxicity was measured as the concentration that inhibits the growth of 50% of cells (IC50).

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PMC11025866

HH514-16 human Burkitt lymphoma cells were cultured in RPMI 1640 + glutamine supplemented with 8% FBS, penicillin (50 U/mL), streptomycin (50 U/mL), and amphotericin B (1 μg/mL).

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PMC11756907

The selective anticancer effect of the designed complexes is a promising solution for innovative oncological therapies for skin cancer in epidermal or subcutaneous administration.

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PMC9014716

(Bar plot): The differential expressions of 5 screened miRNAs (arranging from high level to low level). (

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PMC11547972

The Western blot data did not show homogenous additive or synergistic effects in regard to nearly all investigated cell cycle and apoptosis related proteins.

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PMC11711345

Reviews on the in vitro cytotoxicity of p-cymene are found in the literature but include the ruthenium complexes of this compound .

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PMC9516447

For example, while the inhibitors decreased HRAS and NRAS protein levels in A427, H460, and HCT116 cells, only modest effects were observed for LS180, PANC-1, and CFPAC-1 cells (Supp.

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PMC10878518

The high type of benign group showed almost similar expression levels of CAR and hTERT with the low type of intermediate and malignant group (Fig 5A and 5B).

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PMC11122631

Additionally, most of the predicted Log Kp values for skin permeation of compounds were located in a similar range (−6.55 to −5.26), but only one predicted Log Kp value of compound 1 was −7.04.

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PMC11470381

Optional: Gamma adjustment can be performed to control brightness and contrast of the images to aid the intensity thresholding.

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PMC11714165

Importantly, DN‐F nanoparticles also suppress bone destruction in an osteosarcoma model.

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PMC11696576

Two or three samples were each measured in technical triplicates to give the final % recovery.

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PMC11727907

In addition, the metabolic changes induced by IGF-1 appear to be modulated by Klotho.

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PMC11745600

All male and female homozygous mice exhibited persistent severe hyperglycemia associated with β-cell depletion as early as 4 wk of age and exhibited normal insulin sensitivity.

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PMC9429973

TANITA-SC-240MA device was used to measure body composition by BIA method.

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PMC10823017

This type of cancer stems from the cell lining of the small tubules that usually have either a genetic mutation of a hereditary VHL (Von Hippel-Lindau) or a sporadic mutation in other genes.

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PMC11757131

Regarding de novo fatty acid synthesis, the addition of 3-HIB did not affect the expression levels of the key proteins involved in this process, DGAT and ACC, relative to the control group (p > 0.05) (Figure 4).

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PMC11638288

The extracellular region contains residues 22 to 258 and is characterized by two cysteine-bridged Ig-like N-terminal C2-type domains called D1 (distal membrane domain) and D2 (proximal membrane domain), which span residues 1–94 and 101–188, respectively, and are arranged at an 85° angle to each other.

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PMC11367146

September 25, 2023) was deposited to the herbarium of SOA University.

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PMC9429973

Six of 8 (75%) Ph- pts responded.

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PMC11727145

The scanner microscope Olympus VS200 (Olympus Corporation, Tokyo, Japan) was used to perform imaging.

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PMC9429973

Characteristics of 639 NGS-annotated SMF.

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PMC7090062

In addition, EdU analysis indicated that miR-30a overexpression significantly suppressed the proliferation of IM treated GIST-882/GIST-T1 cells.

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PMC11240571

When the tumors had grown to about 5 mm in diameter, the mice were irradiated with 12 Gy, and exosomes were isolated from the blood of each mouse 1 to 5 days after irradiation.

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PMC10761571

Finally, the DLS size and zeta-potential of Fe3O4@Glu-Gingerol were determined by a HORIBA Scientific SZ-100 Zeta sizer (Japan).

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PMC2193049

After a 24-h incubation at 37°C, supernatants were collected and the TNF-α content was determined in a functional assay using WEHI-164 clone 13 cells (22) as described (23).

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PMC11512230

Ewing sarcoma (ES) is an aggressive tumor of mesenchymal origin that accounts for 10% to 15% of all bone sarcomas, according to various data and classifications .

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PMC10490530

Further, the assay developed is compatible with the standard set of luminescence measurement equipment available and, therefore, can be widely used for many suitable applications.

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PMC9429973

We confirmed the reliability prognostic efficacy of NLR and LMR.

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PMC9424261

Representative images of IB are shown in the figure.

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PMC11742431

In contrast, A375, a PD‐L1 negative cell, had no pro‐apoptotic capacity with KVN and K14N treatment.

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PMC11525028

ASNS is the enzyme responsible for Asn biosynthesis (Figure 4B).

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PMC7709199

The model was refined to an R factor of 0.189 and an R free of 0.217, and its stereochemistry was validated using the MolProbity web service (Chen et al., 2010 ▸), indicating that there were no residues in the disallowed regions of the Ramachandran plot.

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PMC11095939

Intravenous injection of adeno-associated virus (AAV)-TBG-Mecp2 (Greig et al., 2018) reinforced the levels of Mecp2 in hepatocytes compared to empty vector (EV) control cells (Figure 2E and F).

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PMC10878518

The expression levels of CAR and hTERT in the malignant and intermediate group and the benign group were evaluated using the ATM, as reported previously .

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PMC9910796

The possible protein topology was predicted using TMHMM 2.0 at https://services.healthtech.dtu.dk/service.php?TMHMM-2.0.

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PMC9429973

The effect on apoptosis was quantified by AnnexinV/7-AAD staining.

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PMC9581083

In vitro cellular assays and in vivo animal studies are required to confirm these predicted mechanisms.

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PMC9920575

In both pathways, apoptosis is carried out by caspases (cysteine aspartyl-specific proteases), which can function as initiators or executors that cleave target proteins, eventually leading to the death of the cell .

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PMC7685376

Short interfering RNAs (siRNAs) were synthesized by GenePharma (Shanghai, China).

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PMC11674146

Genetic mutations have been shown to partly activate inflammatory pathways and modulate the upstream or downstream targets of pathways in lymphoma (Shi et al., 2024).

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PMC9429973

The majority of the patients had limited or intermediate stage of disease: Ann Arbor stage I/II 51.4%, stage III/IV 48.6%, respectively.

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PMC11745823

In the current diagnostic categories of gliomas, there are usually some landmark molecular markers: 1p/19q coding deletion, mutation and MGMT promoter methylation, among others.

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PMC11756514

Neoglycoproteins were obtained from Dextra: fucose-BSA (Fuc-BSA) (cat.

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PMC11634027

Both Ds-210 and Ds-150 intensities are included in the quantification. (

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PMC6650823

Molecular hybridization is an approach in rational drug design where new chemical entities are obtained by combining two or more pharmacophoric moieties into a single molecule .

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PMC11271278

These results indicate that the enhancers involved in hijacking are already active in cancer cells without the translocation and are cancer-type specific.

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PMC9429973

Grade ≥3 treatment-related AEs occurred in 2 (7%) patients.

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PMC9429973

Image: Summary/Conclusion: This is the first NMA to compare the efficacy of zanubrutinib with all commonly utilized first-line treatment for TN CLL.

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PMC11335267

p < 0.05, **p < 0.01 and ***p < 0.001, two-way ANOVA (A, C and E-N) or Student’s t-test (B, P-Q) Altered response of Alx3-deficient mice to feeding with a high fat diet A) Body weight curves of Alx3-deficient and wild type mice fed with standard chow (SCD) or high-fat (HFD) diets (8–10 animals per group).

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PMC11476222

In-depth ganglioside isomer characterization is useful in many applications; however, it does require additional instrumentation, analysis time, and sample preparation compared to our method.

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PMC8984067

Then, 2 mg anti-EpCAM-UCNPs-Ce6 was added to 5 mL ethanol and dispersed uniformly via ultrasonication to form the solution of nanoparticles, and its absorbance at 404 nm was determined through UV-Vis spectrophotometry.

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PMC11461874

For this purpose, we generated a TRAF7-KO cell line from NIH3T3 cells using the CRISPR-Cas9 genome editing (Fig. 4g).

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PMC9429973

After the first treatment cycle, 93% of evaluable pts (14/15) had <1% of multiple myeloma cells in bone marrow based on flow cytometry.

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PMC11593084

Furthermore, the recognition mode of H2Mab-214 was solved by X-ray crystallography .

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PMC7802142

However, no change was seen upon treatment with 293-NV when compared to PBS (Fig. 3c, d).

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PMC9917080

, fetal bovine serum (10099141); Selenum nanoparticles and sorafenib-doped selenium nanoparticles (SeSo) (courtesy of Dr. SV Gudkov, Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia).

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PMC9119314

The controls were included for the background fluorescence (0% viability; parasites exposed to a supralethal 10 μM chloroquine concentration) and 100% growth (parasites in drug-free wells).

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PMC11741906

Previous studies identified cisplatin as an activator of MAPK pathway in many cancer cells, but this stimulation either prevents or interferes with the induction of cisplatin-induced apoptosis , which makes the role of this pathway needs further studies.

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PMC11754432

Keratinocytes transfected with ALOX15B siRNA for 72 h alone (A–D) or followed by 30 min pre-treatment with 2 µM PD168393 or vehicle (DMSO), then combined with cocktail treatment of 50 ng/ml IL-17A, TNFα and 10 ng/ml IFNγ for 30 min (E, F) or IFNγ alone or 6 h (F).

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PMC7081114

The Kaplan-Meier method was used to assess prognosis significance.

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PMC9429973

CR rate in patient with CK was 60%.

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PMC11686380

pCAG-Myc-GAP43 or pCAG-Myc-GAP43R (0.2 µg each) was co-transfected into COS7 cells with pSuper-shLuc (Control) or pSuper-mGAP43#1 (1.5 µg each).

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PMC11650848

The mQTL rs2747429 resides 21 base pairs downstream from our mQTL (rs365052) and has already been recognised as a mQTL in brain and T-cells .

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PMC2777936

Results presented are an average of duplicate readings.

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PMC11726183

TOF HRMS (m/z): [M + H], calcd: 357.1315, found: 357.1315. %

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