OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC3019555	HIF-1α inhibition requires microtubule disruption Ctrl, control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HIF-1α", "inhibition", "requires", "microtubule", "disruption", "Ctrl", ",", "control", "." ] } ]
PMC11748618	We next accessed data on monocyte eQTLs from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort and observed a significant correlation between eQTLs increasing CHD1L expression and decreased HIV spVL (p ≤ 0.0022) (Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11040965	Differentially methylated regions were identified using the Bumphunter method and defined as 300 bp regions marked by multiple probes and with an overall methylation difference between MGUS and MM patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	In contrast, the palmitoylation inhibitor 2-BP markedly exacerbated liver injury in the ischemia-reperfusion model by promoting ferroptosis, although 2-BP alone did not induce liver damage (Supplementary Fig. 11a–f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637284	This simplifies in vivo studies of the TAC OM-IM contact site because interfering with the TAC60-p166 interaction prevents the formation of each individual TAC cable and thus of the whole structure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	Differential interference contrast (DIC), with overlay of Hoechst dye nuclear stain (DAPI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differential", "interference", "contrast", "(", "...
PMC11640247	This variant is situated in the Switch II region, a critical domain for interactions with effector and regulatory proteins in small GTPases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11463018	Currently, these triazolopyridines are further studied in our lab.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "these", "triazolopyridines", "are", "further", "studied", "in", "our", "lab", ...
PMC7192625	Neutrophils were previously found to display high levels of transcriptomic and epigenomic variability, even taking into account genetic differences between individuals, likely due to their role as the immune system’s first responders (45).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	Compared to the control group, the Lipo-IL11 group showed a slight increase in the green fluorescent signal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "to", "the", "control", "gr...
PMC11684269	Mostly, CD8 TRM is fueled by lipids for long-term residence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mostly", ",", "CD8", "TRM", "is", "fueled", "by", "lipids", "for", "long-term", ...
PMC10808409	P-values represented on the graph reflect the statistical significance of various treatments in comparison to untreated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-values", "represented", "on", "the", "graph", ...
PMC7039683	While gapped kmer support vector machine classifier was the top-performing algorithm at the time we began the study, others are available now that may function better in some circumstances (Liu et al., 2017b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	AU: arbitrary units Representative experiments for n = 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AU", ":", "arbitrary", "units", "Representative", "experiments", "for", "n", "=", "3", "."...
PMC9429973	Aims: In this study we aim at better understanding the relative contributions of the light- and feeding cycle to daily changes in sepsis susceptibility and the metabolic requirements of hematopoietic stem cells as the origin of immune cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	EC5 measurements for the MART-reactive TCRs did not reveal a clear relationship between TCR-mem and binding affinity (Figure S6E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EC5", "measurements", ...
PMC9429973	Somatic acquired alterations in patients with inherited myeloid malignancies syndromes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Somatic", "acquired", "alterations", "in", "patients", "with", "inherited", "myeloid", "malignancies",...
PMC11757230	∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 vs. LL cells cultured alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "<", "0.05", ",", "∗∗p", "<", "0.01", ...
PMC11271278	C HiChIP and ChIP-seq signal at chromosomal regions containing CCND1 and the hijacked enhancers in REC1 and ZR751 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "C", "HiChIP", "and", ...
PMC11484188	The present study investigated whether miR-1343-3p regulates ATG7 through its 3'UTR by cloning ATG7 3'UTR into a luciferase vector.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "present", ...
PMC11720107	After thawing, the cells were lysed using lysis buffer (50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol, and 10 mM DTT) at 10 °C for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10965680	Specific consent procedures were not necessary, as we adhered to the National Standard for the Care and Use of Laboratory Animals to ensure the animals’ wellbeing and safety.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711063	Increased fibronectin‐1 levels, a shift in integrin isoforms upon ZG16B exposure and reduced epithelial cell adhesion allow tumor‐promoting mesenchymal cells to migrate into the growing tumor mass. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6642070	Cells with indicated treatments were seeded in XFp cell culture miniplates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "with", "indicated", "treatments", "were", "seeded", "in", "XFp", "cell", "cu...
PMC10253973	However, side effects were noticed when the maximum dose of the drug was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "side", "effects", "were", "noticed", "when"...
PMC11806613	Quantification of protein expressions are shown on top.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "protein", "expressions", "are", "shown", "on", "top", "." ] } ]
PMC11190238	To decipher the role of 3D genome in the regulation of EMT at the single cell resolution, technical breakthroughs are crucial to accelerate discovery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11682525	Cell viability under hypoxic conditions and oxidative stress was assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "under", "hypoxic", "conditions", "and", "oxidative", "stress", "was", "asse...
PMC11694625	The results revealed that both 3b and 3c could effectively trigger concentration dependent apoptosis of MCF-7 cells, which was consistent with that of AO/EB double staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Tumors were engrafted for 7 days (reaching 50–100 mm) before commencing treatment with saline or TEPA (400 mg/kg) for 7 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Here, we report the results of our Phase 1 study evaluating HSP-CAR30 for the treatment of R/R HL and CD30 T-cell non-Hodgkin lymphoma (T-NHL) (NCT04653649).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718817	The total number of untreated macrophages (identified by TgVenus positivity) within the spheroids increased by 115% from 4 h to 18 h (5.55 ± 3.54 at 4 h versus 11.95 ± 5.04 at 18 h, light blue bars), indicating directed migration of macrophages into spheroids over time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705484	Scale bar: 100 µm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "100", "µm", ".", "(" ] } ]
PMC10813895	Among women diagnosed with BC, a significant majority (90%) do not exhibit inherited mutations or have a family history of the disease, underscoring the predominance of sporadic over inherited BC cases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	The observation that VAL-wt, which do not express ACKR3 on the surface, can migrate towards CXCL12 in the presence of cells exposing the receptor on the plasma membrane was intriguing ( Figure 1D ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11703992	E Functional enrichment of DEGs in DDIT4+ / − CD4+ Memory T cells, conducted by metascape.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "Functional", "enrichment", "...
PMC11695623	The cell count after transfection was collected, and 5 × 10 cells were inoculated in the upper chamber with 200 μl serum-free medium, and 750 μl medium containing 20% fetal bovine serum was added to the lower chamber.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11310713	The beads produced secondly with small beads were 800 to 1,000 μm in size and contained 8 to 10 beads, using a 20-gauge needle with 1.5% alginate containing TCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476264	Then, the docking combination with the best docking effect (model No. 1) was selected based on the docking score and confidence score and analyzed using PyMOL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10810426	Interestingly, previous studies have suggested that gammaretroviruses can infect other quiescent cell types, such as neurons .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "previous", "studies", ...
PMC11138140	After the position selection, live rat cardiac cultures were imaged on the Holomonitor M4 for 24 h, with time points taken every 20 min at 37 °C and 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629143	Error bars represent ± SEM, n = 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "±", "SEM", ",", "n", "=", "3", "." ] } ]
PMC9429973	Most popular mobilization regimens are with G-CSF given as a sole treatment or in combination with cyclophosphamide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "popular", "mobilization", "regimens", "ar...
PMC11185260	In our study, we used patient-derived cell lines (BT-12 and CHLA-06) that exhibit features that are more similar to the ATRT-MYC subgroup, with elevated expression of the MYC oncogene and activated MYC target genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11718817	The presence of macrophages increased T cellular motility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "presence", "of", "macrophages", "increased", "T", "cellular", "motility", "." ] } ]
PMC9429973	One or more additional non-driver mutations were present in 3/5 CALR, and in 3/8 JAK2V617Fmutated pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "or", "more", "additional", "non-driver", ...
PMC11347429	Here, we performed transcriptome and genotype analysis in healthy controls and patients exhibiting mild/moderate or severe influenza (ICU patients).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", ...
PMC11609529	The specific MAML2 KO was confirmed via western blot (WB) analysis (bottom). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "specific", "MAML2", "KO", "was", "co...
PMC10976516	Lysis of tumor cells is caused by viral replication and the activation of cell death mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lysis", "of", "tumor", "cells", "is", "caused", ...
PMC11802929	As expected, cytotoxic and EM phenotypes dominate the SARS-Cov-2-specific CD8 T cell response during acute disease, with elevated effector markers such as GZMB, GZMA, and PRF1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9275501	Rhein could increase the accumulation of DOX in SMMC-7721/DOX cells by inhibiting energy metabolism and inducing the opening of mitochondrial permeability transition pore (mPTP), and reverse the drug resistance of SMMC-7721/DOX cells (Wu et al., 2019a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	The cell growth rate was calculated as the cell number over time between passages (seven days).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "growth", "rate", "was",...
PMC11774251	The samples were separated using a 10% SDS-PAGE gel and subsequently transferred to a PVDF membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "were", "separated", "using", ...
PMC10968586	The great majority of ovarian cancers are classified as epithelial belonging to the serous subtype .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "great", "majority", "of", "ovarian", "cancers", "are...
PMC11628309	Notably, there is significant variation in the types of media used for culturing this cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "there", "is", "significant", ...
PMC9429973	Of 16 pts with a BL T-score of ≤–2.5, 1 pt improved to a T-score of >–2.5 to <–1.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "16", ...
PMC11718109	For live imaging, cells were maintained in Live Cell Imaging buffer (Life Technologies) for COS7 cells, while both iNeurons and DA neurons were maintained in CM and NB/B27 media, respectively, in a caged incubator with humidified atmosphere (5% CO2) at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476666	For the analysis of DNA content, A549 were treated for 24 h with 1, 15, and 30 µM of DHS or RSV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11252553	The volunteers were carefully selected and met specific criteria: they were non-smokers, non-alcoholic, not currently taking any medication or supplements, free from any known diseases, and had no history of recent exposure to IR within the last month.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	Similar to the effects on cell viability, combining AVX420 with exogenous AA did not prevent the increased iROS (Fig. S9c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar...
PMC11629461	A growing flask of CHO‐K1 (RRID: CVCL‐0214) cells was from the Chinese Academy of Sciences Shanghai Institute of Life Sciences.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11758416	n = 3 (D) Annexin V staining in L cells pre-incubated with anti-CD3 after incubation with unstimulated or anti-CD3/anti-CD28 stimulated naive (∗∗p ≤ 0.01), memory (∗∗p ≤ 0.01) or TEMRA CD8+ T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10854447	Yield: 0.17 g (67%), white solid, mp: 128–130 °C, Rf: 0.71 (hexane:ethyl acetate, 2:1, v/v).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9545714	Prior to taking the measurement, subjects were acclimatized in an environmental room at 21°C and 50% relative humidity for 20 minutes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9646302	LAPTM5 also mediates cell death in neuroblastoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LAPTM5", "also", "mediates", "cell", "death", "in", "neuroblastoma", "." ] } ]
PMC11388384	Cell culture media were supplemented with conditioned media as required for the experiment and induced to signal for ~18 h. For experiments utilizing hSCUBE1 conditioned media, the total amount of conditioned medium was held constant between conditions by supplementing tissue culture medium with conditioned media from ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10154881	At day 8, immature BMDCs were stimulated with 100 ng/mL LPS (Invitrogen) overnight, followed by 2 h cultivation with 1 μg/mL ova peptide (SIINFEKL, MBL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10944868	Notably, drugs targeting vinca, colchicine, and taxane sites are extensively studied MTAs, historically employed as medicines (Matthew et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588	The consequence of damage to platelet mitochondria and their excessive activation is the induction of cardiovascular and neurodegenerative diseases (Parkinson’s and Alzheimer’s), as well as carbohydrate metabolism disorders (diabetes).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445	Morphological changes which ultimately lead to the death of the larvae were setae and anal ventral brush damage, abdominal alterations and extended necks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11711935	The mechanism by which bFGF promotes melanocyte migration is related to the activation of the PI3K/Akt rac1‐FAK‐JNK and ERK signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanism", ...
PMC10125312	On the other hand, A549 cells appeared to have a membrane that is more resistant to hyperthermia and laser irradiation, with a viability over 90% (Figure 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	In short, functional MCT4 inhibition prevents the extrusion of acidic lactate, which acidifies the cytosol of the MCT4-expressing cancer cell line MDA-MB-231.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", ...
PMC7022782	1.49h (Waine Rasband; NIH, Bethesda, MD, USA) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1.49h", "(", "Waine", "Rasband", ";", "NIH", ",", "Bethesda", ",", ...
PMC9429973	Up to 10/FEB/2022, 43 TDT patients (median age 43.52 range 18.6-57.9 years) were diagnosed with COVID-19, with 1 of them being infected twice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	E UVB skin damage of WT mice and Zbp1 mice was evaluated by scores (n = 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "UVB", "skin", "damage", ...
PMC11190238	Single cell transcriptomic profiling has shown that EMT is not a linear but highly variable process that branches into various trajectories upon induction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single"...
PMC11518994	PAX5 expression was evaluated in CASE B (A), in the wild-type mother (B), control lymphoblastoid cell line (C); only the wild-type PAX5 protein (42 kD) was detected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10654497	Furthermore, individuals with subtype C1 had higher rates of immune checkpoints and human leukocyte antigen (HLA) cell infiltration than patients with subtype C2 (Fig. 5G,H).Figure 5Immune landscape of patients with subtypes C1 and C2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912	In addition, in a study published earlier this year, GSK795 and GSK254 potently inhibited HIV-2ROD replication in MT-2 cells when reverse transcriptase activity was used as the assay endpoint (IC50s, 17 and 2.5 nM, respectively) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC3931643	Nascent protein synthesis was analyzed by measuring the uptake of L-azidohomoalanine (AHA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nascent", "protein", "synthesis", "was", "analyzed", "by", "measuring"...
PMC11574271	Fig. 5RON is identified as a target of hsa-miR-659-3p in bladder cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5RON", "is", "identified", "as", "a", "target", ...
PMC7823217	Hanging drop technique has been utilized previously to create 3D tumors in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hanging", "drop", "technique", "has", "been", "utilized", "previously", "to...
PMC9429973	Grade 3 or 4 TRAEs occurred in 6 patients (20%) and 10% of patients discontinued due to TRAEs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grade", "3",...
PMC11753435	On the basis of the seminal work of Portnoff et al. (8), we recently reprogrammed the specificity of a modular human E3 ubiquitin ligase called CHIP (C terminus of Hsc70-interacting protein) by replacing its natural substrate-binding domain, TPR, with designer “guide” peptide motifs to generate minimal, genetically enc...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9430052	The primary objectives were safety and tolerability, secondary objectives were pharmacokinetics and efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "objectives", "were", "safety", "and", "tolerability"...
PMC11756907	In the course of the research and development, stable derivatives of 2-ME were obtained, which solve the problem mentioned above.36–38 The solution brings a new and surprising effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME, through its complexation with graphene nanoflakes, wh...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	Gradients were held in 32% buffer B for 0.5 min and run from 32% buffer B to 45% buffer B at 0.5–4 min; from 45% buffer B to 52% buffer B at 4–5 min; from 52% buffer B to 58% buffer B at 5–8 min; from 58% buffer B to 66% buffer B at 8–11 min; from 66% buffer B to 70% buffer B at 11–14 min; from 70% buffer B to 75% buff...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628309	This easy access to well-characterized and validated cell models is crucial for ensuring reproducibility and enabling the comparison of results across different laboratories.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC8658661	In addition, due to the low basal activity of CYP proteins (CYP1A2, CYP2B6, and CYP3A4), the cell line can be used in studies of CYP inducers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11587606	Typical images of invasion for CRT0066854 stimulated MCF10A/GFP and MCF10A/RH cells; scale bar 100 μm; bar graphs show the ratio of invasion cells (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	Aedes aegypti and Aedes albopictus are the main vectors that spread the virus to humans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aedes", "aegypti", "and", "Aedes", "albopictus", "are", "th...
PMC10530622	It has been established that renal survival (dialysis-free) is worse for PH1 compared to all others.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "established", "th...
PMC8956657	As expected, the Arg33 bound at the Gly150, Thr155, and Asp192 pocket.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "the", "Arg33", "bound", "at", ...
PMC11763126	PCR analysis revealed that knocking down YTHDF2 significantly increased TRPM3 mRNA levels, whereas overexpressing YTHDF2 significantly decreased TRPM3 mRNA levels (Fig. 7C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11204465	One new compound, O-methylsterigmatocystin (30), was isolated and identified from the secondary metabolites of the fungus Aspergillus flavus . (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", ...
PMC11401358	Statistical analysis of secondary structure in untreated and H2O2-treated (GAGSGA)2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "of", "secondary", "structure", "in", "untreated", "and", "H2O2-t...
PMC11706491	The combination of these markers enables precise identification of each cell cycle phase and determination of the total cycle duration (Fig 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC3164356	Thus, the lack of CMAH expression in the CHO-K1 sample minimizes this response by limiting the conversion of Neu5Ac to Neu5Gc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ...
PMC11629143	These data support a mechanism in which targeted recruitment of dCas9‐p300 to the CMV promoter stimulates acetylation of H3K27 to create a recognition site for BRD4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC3019555

HIF-1α inhibition requires microtubule disruption Ctrl, control.

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PMC11748618

We next accessed data on monocyte eQTLs from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort and observed a significant correlation between eQTLs increasing CHD1L expression and decreased HIV spVL (p ≤ 0.0022) (Fig. 3B).

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PMC11040965

Differentially methylated regions were identified using the Bumphunter method and defined as 300 bp regions marked by multiple probes and with an overall methylation difference between MGUS and MM patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11746948

In contrast, the palmitoylation inhibitor 2-BP markedly exacerbated liver injury in the ischemia-reperfusion model by promoting ferroptosis, although 2-BP alone did not induce liver damage (Supplementary Fig. 11a–f).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11637284

This simplifies in vivo studies of the TAC OM-IM contact site because interfering with the TAC60-p166 interaction prevents the formation of each individual TAC cable and thus of the whole structure.

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PMC11489351

Differential interference contrast (DIC), with overlay of Hoechst dye nuclear stain (DAPI).

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PMC11640247

This variant is situated in the Switch II region, a critical domain for interactions with effector and regulatory proteins in small GTPases.

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PMC11463018

Currently, these triazolopyridines are further studied in our lab.

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PMC7192625

Neutrophils were previously found to display high levels of transcriptomic and epigenomic variability, even taking into account genetic differences between individuals, likely due to their role as the immune system’s first responders (45).

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PMC11783017

Compared to the control group, the Lipo-IL11 group showed a slight increase in the green fluorescent signal.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "to", "the", "control", "gr...

PMC11684269

Mostly, CD8 TRM is fueled by lipids for long-term residence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mostly", ",", "CD8", "TRM", "is", "fueled", "by", "lipids", "for", "long-term", ...

PMC10808409

P-values represented on the graph reflect the statistical significance of various treatments in comparison to untreated cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-values", "represented", "on", "the", "graph", ...

PMC7039683

While gapped kmer support vector machine classifier was the top-performing algorithm at the time we began the study, others are available now that may function better in some circumstances (Liu et al., 2017b).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11599565

AU: arbitrary units Representative experiments for n = 3.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AU", ":", "arbitrary", "units", "Representative", "experiments", "for", "n", "=", "3", "."...

PMC9429973

Aims: In this study we aim at better understanding the relative contributions of the light- and feeding cycle to daily changes in sepsis susceptibility and the metabolic requirements of hematopoietic stem cells as the origin of immune cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11785489

EC5 measurements for the MART-reactive TCRs did not reveal a clear relationship between TCR-mem and binding affinity (Figure S6E).

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PMC9429973

Somatic acquired alterations in patients with inherited myeloid malignancies syndromes.

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PMC11757230

∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 vs. LL cells cultured alone.

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PMC11271278

C HiChIP and ChIP-seq signal at chromosomal regions containing CCND1 and the hijacked enhancers in REC1 and ZR751 cells.

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PMC11484188

The present study investigated whether miR-1343-3p regulates ATG7 through its 3'UTR by cloning ATG7 3'UTR into a luciferase vector.

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PMC11720107

After thawing, the cells were lysed using lysis buffer (50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol, and 10 mM DTT) at 10 °C for 10 min.

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PMC10965680

Specific consent procedures were not necessary, as we adhered to the National Standard for the Care and Use of Laboratory Animals to ensure the animals’ wellbeing and safety.

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PMC11711063

Increased fibronectin‐1 levels, a shift in integrin isoforms upon ZG16B exposure and reduced epithelial cell adhesion allow tumor‐promoting mesenchymal cells to migrate into the growing tumor mass. ,

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PMC6642070

Cells with indicated treatments were seeded in XFp cell culture miniplates.

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PMC10253973

However, side effects were noticed when the maximum dose of the drug was used.

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PMC11806613

Quantification of protein expressions are shown on top.

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PMC11190238

To decipher the role of 3D genome in the regulation of EMT at the single cell resolution, technical breakthroughs are crucial to accelerate discovery.

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PMC11682525

Cell viability under hypoxic conditions and oxidative stress was assessed.

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PMC11694625

The results revealed that both 3b and 3c could effectively trigger concentration dependent apoptosis of MCF-7 cells, which was consistent with that of AO/EB double staining.

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PMC11638255

Tumors were engrafted for 7 days (reaching 50–100 mm) before commencing treatment with saline or TEPA (400 mg/kg) for 7 days.

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PMC9429973

Here, we report the results of our Phase 1 study evaluating HSP-CAR30 for the treatment of R/R HL and CD30 T-cell non-Hodgkin lymphoma (T-NHL) (NCT04653649).

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PMC11718817

The total number of untreated macrophages (identified by TgVenus positivity) within the spheroids increased by 115% from 4 h to 18 h (5.55 ± 3.54 at 4 h versus 11.95 ± 5.04 at 18 h, light blue bars), indicating directed migration of macrophages into spheroids over time.

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PMC11705484

Scale bar: 100 µm. (

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PMC10813895

Among women diagnosed with BC, a significant majority (90%) do not exhibit inherited mutations or have a family history of the disease, underscoring the predominance of sporadic over inherited BC cases .

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PMC9878562

The observation that VAL-wt, which do not express ACKR3 on the surface, can migrate towards CXCL12 in the presence of cells exposing the receptor on the plasma membrane was intriguing ( Figure 1D ).

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PMC11703992

E Functional enrichment of DEGs in DDIT4+ / − CD4+ Memory T cells, conducted by metascape.

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PMC11695623

The cell count after transfection was collected, and 5 × 10 cells were inoculated in the upper chamber with 200 μl serum-free medium, and 750 μl medium containing 20% fetal bovine serum was added to the lower chamber.

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PMC11310713

The beads produced secondly with small beads were 800 to 1,000 μm in size and contained 8 to 10 beads, using a 20-gauge needle with 1.5% alginate containing TCs.

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PMC11476264

Then, the docking combination with the best docking effect (model No. 1) was selected based on the docking score and confidence score and analyzed using PyMOL.

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PMC10810426

Interestingly, previous studies have suggested that gammaretroviruses can infect other quiescent cell types, such as neurons .

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PMC11138140

After the position selection, live rat cardiac cultures were imaged on the Holomonitor M4 for 24 h, with time points taken every 20 min at 37 °C and 5% CO2.

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PMC11629143

Error bars represent ± SEM, n = 3.

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PMC9429973

Most popular mobilization regimens are with G-CSF given as a sole treatment or in combination with cyclophosphamide.

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PMC11185260

In our study, we used patient-derived cell lines (BT-12 and CHLA-06) that exhibit features that are more similar to the ATRT-MYC subgroup, with elevated expression of the MYC oncogene and activated MYC target genes.

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PMC11718817

The presence of macrophages increased T cellular motility.

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PMC9429973

One or more additional non-driver mutations were present in 3/5 CALR, and in 3/8 JAK2V617Fmutated pts.

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PMC11347429

Here, we performed transcriptome and genotype analysis in healthy controls and patients exhibiting mild/moderate or severe influenza (ICU patients).

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PMC11609529

The specific MAML2 KO was confirmed via western blot (WB) analysis (bottom). (

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PMC10976516

Lysis of tumor cells is caused by viral replication and the activation of cell death mechanisms.

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PMC11802929

As expected, cytotoxic and EM phenotypes dominate the SARS-Cov-2-specific CD8 T cell response during acute disease, with elevated effector markers such as GZMB, GZMA, and PRF1.

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PMC9275501

Rhein could increase the accumulation of DOX in SMMC-7721/DOX cells by inhibiting energy metabolism and inducing the opening of mitochondrial permeability transition pore (mPTP), and reverse the drug resistance of SMMC-7721/DOX cells (Wu et al., 2019a).

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PMC8345486

The cell growth rate was calculated as the cell number over time between passages (seven days).

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PMC11774251

The samples were separated using a 10% SDS-PAGE gel and subsequently transferred to a PVDF membrane.

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PMC10968586

The great majority of ovarian cancers are classified as epithelial belonging to the serous subtype .

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PMC11628309

Notably, there is significant variation in the types of media used for culturing this cell line.

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PMC9429973

Of 16 pts with a BL T-score of ≤–2.5, 1 pt improved to a T-score of >–2.5 to <–1.0.

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PMC11718109

For live imaging, cells were maintained in Live Cell Imaging buffer (Life Technologies) for COS7 cells, while both iNeurons and DA neurons were maintained in CM and NB/B27 media, respectively, in a caged incubator with humidified atmosphere (5% CO2) at 37 °C.

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PMC11476666

For the analysis of DNA content, A549 were treated for 24 h with 1, 15, and 30 µM of DHS or RSV.

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PMC11252553

The volunteers were carefully selected and met specific criteria: they were non-smokers, non-alcoholic, not currently taking any medication or supplements, free from any known diseases, and had no history of recent exposure to IR within the last month.

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PMC11696576

Similar to the effects on cell viability, combining AVX420 with exogenous AA did not prevent the increased iROS (Fig. S9c).

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PMC11629461

A growing flask of CHO‐K1 (RRID: CVCL‐0214) cells was from the Chinese Academy of Sciences Shanghai Institute of Life Sciences.

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PMC11758416

n = 3 (D) Annexin V staining in L cells pre-incubated with anti-CD3 after incubation with unstimulated or anti-CD3/anti-CD28 stimulated naive (∗∗p ≤ 0.01), memory (∗∗p ≤ 0.01) or TEMRA CD8+ T cells.

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PMC10854447

Yield: 0.17 g (67%), white solid, mp: 128–130 °C, Rf: 0.71 (hexane:ethyl acetate, 2:1, v/v).

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PMC9545714

Prior to taking the measurement, subjects were acclimatized in an environmental room at 21°C and 50% relative humidity for 20 minutes.

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PMC9646302

LAPTM5 also mediates cell death in neuroblastoma.

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PMC11388384

Cell culture media were supplemented with conditioned media as required for the experiment and induced to signal for ~18 h. For experiments utilizing hSCUBE1 conditioned media, the total amount of conditioned medium was held constant between conditions by supplementing tissue culture medium with conditioned media from ...

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PMC10154881

At day 8, immature BMDCs were stimulated with 100 ng/mL LPS (Invitrogen) overnight, followed by 2 h cultivation with 1 μg/mL ova peptide (SIINFEKL, MBL).

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PMC10944868

Notably, drugs targeting vinca, colchicine, and taxane sites are extensively studied MTAs, historically employed as medicines (Matthew et al., 2021).

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PMC11594588

The consequence of damage to platelet mitochondria and their excessive activation is the induction of cardiovascular and neurodegenerative diseases (Parkinson’s and Alzheimer’s), as well as carbohydrate metabolism disorders (diabetes).

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PMC11155445

Morphological changes which ultimately lead to the death of the larvae were setae and anal ventral brush damage, abdominal alterations and extended necks.

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PMC11711935

The mechanism by which bFGF promotes melanocyte migration is related to the activation of the PI3K/Akt rac1‐FAK‐JNK and ERK signaling pathways.

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PMC10125312

On the other hand, A549 cells appeared to have a membrane that is more resistant to hyperthermia and laser irradiation, with a viability over 90% (Figure 5B).

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PMC9841531

In short, functional MCT4 inhibition prevents the extrusion of acidic lactate, which acidifies the cytosol of the MCT4-expressing cancer cell line MDA-MB-231.

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PMC7022782

1.49h (Waine Rasband; NIH, Bethesda, MD, USA) .

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PMC9429973

Up to 10/FEB/2022, 43 TDT patients (median age 43.52 range 18.6-57.9 years) were diagnosed with COVID-19, with 1 of them being infected twice.

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PMC11762280

E UVB skin damage of WT mice and Zbp1 mice was evaluated by scores (n = 5).

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PMC11190238

Single cell transcriptomic profiling has shown that EMT is not a linear but highly variable process that branches into various trajectories upon induction.

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PMC11518994

PAX5 expression was evaluated in CASE B (A), in the wild-type mother (B), control lymphoblastoid cell line (C); only the wild-type PAX5 protein (42 kD) was detected.

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PMC10654497

Furthermore, individuals with subtype C1 had higher rates of immune checkpoints and human leukocyte antigen (HLA) cell infiltration than patients with subtype C2 (Fig. 5G,H).Figure 5Immune landscape of patients with subtypes C1 and C2. (

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PMC9847912

In addition, in a study published earlier this year, GSK795 and GSK254 potently inhibited HIV-2ROD replication in MT-2 cells when reverse transcriptase activity was used as the assay endpoint (IC50s, 17 and 2.5 nM, respectively) .

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PMC3931643

Nascent protein synthesis was analyzed by measuring the uptake of L-azidohomoalanine (AHA).

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PMC11574271

Fig. 5RON is identified as a target of hsa-miR-659-3p in bladder cancer cells.

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PMC7823217

Hanging drop technique has been utilized previously to create 3D tumors in vitro.

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PMC9429973

Grade 3 or 4 TRAEs occurred in 6 patients (20%) and 10% of patients discontinued due to TRAEs.

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PMC11753435

On the basis of the seminal work of Portnoff et al. (8), we recently reprogrammed the specificity of a modular human E3 ubiquitin ligase called CHIP (C terminus of Hsc70-interacting protein) by replacing its natural substrate-binding domain, TPR, with designer “guide” peptide motifs to generate minimal, genetically enc...

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PMC9430052

The primary objectives were safety and tolerability, secondary objectives were pharmacokinetics and efficacy.

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PMC11756907

In the course of the research and development, stable derivatives of 2-ME were obtained, which solve the problem mentioned above.36–38 The solution brings a new and surprising effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME, through its complexation with graphene nanoflakes, wh...

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PMC11770130

Gradients were held in 32% buffer B for 0.5 min and run from 32% buffer B to 45% buffer B at 0.5–4 min; from 45% buffer B to 52% buffer B at 4–5 min; from 52% buffer B to 58% buffer B at 5–8 min; from 58% buffer B to 66% buffer B at 8–11 min; from 66% buffer B to 70% buffer B at 11–14 min; from 70% buffer B to 75% buff...

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PMC11628309

This easy access to well-characterized and validated cell models is crucial for ensuring reproducibility and enabling the comparison of results across different laboratories.

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PMC8658661

In addition, due to the low basal activity of CYP proteins (CYP1A2, CYP2B6, and CYP3A4), the cell line can be used in studies of CYP inducers .

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PMC11587606

Typical images of invasion for CRT0066854 stimulated MCF10A/GFP and MCF10A/RH cells; scale bar 100 μm; bar graphs show the ratio of invasion cells (n = 3).

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PMC9812014

Aedes aegypti and Aedes albopictus are the main vectors that spread the virus to humans.

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PMC10530622

It has been established that renal survival (dialysis-free) is worse for PH1 compared to all others.

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PMC8956657

As expected, the Arg33 bound at the Gly150, Thr155, and Asp192 pocket.

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PMC11763126

PCR analysis revealed that knocking down YTHDF2 significantly increased TRPM3 mRNA levels, whereas overexpressing YTHDF2 significantly decreased TRPM3 mRNA levels (Fig. 7C).

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PMC11204465

One new compound, O-methylsterigmatocystin (30), was isolated and identified from the secondary metabolites of the fungus Aspergillus flavus . (

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PMC11401358

Statistical analysis of secondary structure in untreated and H2O2-treated (GAGSGA)2. (

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PMC11706491

The combination of these markers enables precise identification of each cell cycle phase and determination of the total cycle duration (Fig 1A).

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PMC3164356

Thus, the lack of CMAH expression in the CHO-K1 sample minimizes this response by limiting the conversion of Neu5Ac to Neu5Gc.

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PMC11629143

These data support a mechanism in which targeted recruitment of dCas9‐p300 to the CMV promoter stimulates acetylation of H3K27 to create a recognition site for BRD4.

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