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PMC11300639
k 786-O cells were treated with indicated chemicals for 24 h. Cells were harvested for immunoprecipitation and western blotting assay.
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PMC11277157
It is evident that already 26 h post-transfection DJ-1 transcripts are strongly suppressed.
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PMC11572213
Our study aimed to investigate the association between TET2-knockdown AML cell line HL-60 cells and glutamine metabolism.
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PMC11615101
The bar graph represents IL-6 mRNA level after knockdown of α-Taxilin and pure protein induction of TNF-α and α-Taxilin along with control groups. (
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PMC10813895
This trend complicates the maintenance of ER+ luminal epithelial cells in primary human mammary epithelial cell cultures over successive passages.
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PMC11775197
Numerous studies have shown a potential association between ncRNAs and cancer development.
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PMC9611901
This is because the cells are grown in a liquid medium, unlike skin cells, which are organised in a very specific tissue.
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PMC10589262
Relative tumor volume was measured at indicated days in vehicle, IM (50 mg/kg), PF (30 mg/kg), bortezomib (Bor, 1 mg/kg), and PF with bortezomib treatment groups.
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PMC10882807
After dewaxed with xylene and gradient of ethanol concentration.
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PMC9429973
The estimand framework guided the design of a clinical study in AML post SCT to conceptualize the assessment of a treatment strategy.
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PMC11740207
Some studies suggest that SCs can evade the HE through AD, enabling them to divide for extended longevity (Morrison and Kimble, 2006).
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PMC11190062
The cells were cultured in RPMI-1640 medium with 20% heat-inactivated fetal calf serum (FCS) during expansion and 10% FCS for experiments.
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PMC10723784
The damage to the DNA will activate ATM/ATR signaling which involves p53 and consequently an increase in the level of p21.
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PMC11332076
TM, transmembrane domain; myc, myc-tag; F, farnesylation signal; F-iIR, farnesylated intracellular domain of IR; F-iIGF1R, farnesylated intracellular domain of IGF1R.B: Cellular localization of IR and IGF1R in Cos-7 and Neuro2A cells transfected with the indicated plasmids.
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PMC11772449
A-F: Knockdown of p38γ can enhance the inhibitory effect of Sora on the proliferation of hepatocellular carcinoma cells.
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PMC9429973
Copanlisib is an intravenous pan-class I PI3K inhibitor with predominant activity against PI3K-α and -δ isoforms, active as single agent in DLBCL with ORR 25% (NCT02391116).
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PMC9429973
It is currently the only approved first-line (1L) treatment for adult patients (pts) with BPDCN in Europe.
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PMC9444294
Two microliters of each sample was mixed with 8 µL of Fast SYBR™ Green Master Mix (Sigma-Aldrich, #4385612, St Louis, MI, USA) and the respective primer pairs, and subsequently run on an ABI ViiA7 qPCR system.
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PMC7823217
Schiele et al. reported successful encapsulation of neural stem cells, pulmonary artery endothelial cells, myoblasts, dermal fibroblasts, breast cancer cells within Matrigel™-based constructs .
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PMC9429973
4.
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PMC9541067
The original article has been corrected
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PMC10530622
This perspective may offer something substantial that helps advance understanding of effective management and draws attention to the novel class of treatments available in clinical practice.
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PMC4277423
To generate pseudotypes with the HIV-1 vector, 4×10 293T packaging cells were co-transfected with 10 µg of HIV-1-luciferase transfer vector and 10 µg of DNA plasmid encoding one of HIV-1 envelopes pDOL, CNE3, CNE11, CNE30 and Yu-2 or control retroviral envelope 10A1 using a calcium phosphate precipitation method .
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PMC11577421
Schematic illustration of albumin-coated NP with interacting heparin molecules. (
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PMC9429973
Increasingly, RWD is being used in support of regulatory decision-making to evaluate outcomes compared to what is observed in clinical trials.
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PMC9429973
Median duration of therapy was 4.2 months (range 0.5–11.9) and median number of cycles reached was 5.0 (range 1.0–11.0).
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PMC11306019
Comparing LT with 2′,4′,6′,3,4-pentahydroxychalcone (PCC), which maintains double bond conjugation, showed PCC´s very weak antagonistic effect (AI = 298) (Figure 4B).
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PMC11743316
NDCDSs use a mixture of at least two chemotherapeutic medicines with differing physicochemical and physiological characteristics .
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PMC10850553
Data represents as mean ± s.e.m (n = 6 in each group).
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PMC11615743
Hoechst 33 342, tetramethylethylenediamine (TEMED), and ammonium persulfate (APS) were purchased from Merck Millipore (Darmstadt, Germany).
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PMC11359735
CSP runs as 2 to 3 bands by SDS-PAGE (27, 28), with the lower band being the product of a proteolytic cleavage event that results in the removal of 10 kDa from the N-terminus (29).
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PMC11155445
Pi-donors, hydrogen interactions of phenyl ring with amino acid ASN62 and pi-sigma interaction of phenyl with LEU198 were also shown by docking studies (141) also showed alkyl and pi-alkyl interactions with amino acids VAL121, HIS119, ALA65 and HIS96.
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PMC11767793
In summary, based on the UV–Vis absorbance, the Au-PEI@NIST was stable in PBS, showed moderate agglomeration without core fusion in DMEM, and had improved stability when FBS was included in DMEM.
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PMC11535726
Schoch et al. (2006) further confirmed the connection between the sexual and asexual morphs of Kirschsteiniothelia, based on both morphology and phylogenetic analysis of SSU, LSU, tef1-α and rpb2.
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PMC7553912
However, intratubular crystals are grown within a very short time period, 3–6 days, compared with the other mouse model using C57BL/6 mice, the high-oxalate/calcium-free diet-fed model, which needs 14 days to grow crystals.
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PMC11011837
The resulting matrix was imported into MetaboAnalyst, where a normalization of the samples was applied with the median.
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PMC11394730
This energy is broken down through metabolic processes such as glycolysis and OXPHOS-mediated cellular respiration.
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PMC11350568
An array of studies have demonstrated that PTK7 (Tyrosine-protein kinase-like 7) plays important roles as a context-dependent signaling switch for the Wnt pathways, Sgc8c was thus selected as the MAPOI targeting aptamer.
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PMC10850553
IA lesions (Aneurysm) or control arterial walls (Superficial temporal artery) were harvested subjected to immunohistochemical analyses.
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PMC11599565
Green arrows denote an upregulation, red arrows a downregulation at the transcriptional level.
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PMC5673955
Counting 5x10 cells at each point was performed by flow cytometry.
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PMC11564322
Similarly, the co-treatment with the c-SRC inhibitor I and the VGVAPG or VVGPGA peptides decreased the AKT kinase protein expression by 60.97 and 32.29%, respectively, compared to the control (Fig. 6G).
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PMC11291697
Statistically significant p-values are expressed as *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001, respectively.
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PMC6163708
To study whether a GLI-responsive promoter-reporter is also affected by HH inhibitors GANT61 and cyclopamine, 12xGLI-luciferase reporter and a reference plasmid were cotransfected in several cell lines that were either variably responsive or nonresponsive to GANT61 in proliferation assays.
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PMC10907726
Total protein was harvested by using RIPA (Biyuntian, China) including protease inhibitors.
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PMC9429973
At Week 48, mean (SEM) ARC CFB was – 57 (21.8) 10/µL (178 [20.7] vs. 121 [15.5] 10/µL), mean (SEM) % PNH RBC/WBC clone size increased from 51.9% (4.4%) to 93% (2.7%), and mean (SEM) LDH CFB was –70.5% (6.18%).
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PMC11676674
In our study, the C. monspeliensis leaf extract at the highest concentration tested (200 μg/mL) significantly increased cytostasis (23.96 ± 0.73%) compared to the negative control cells, indicating an effect of less than 50% cytotoxicity.
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PMC4695073
After routine deparaffinization, rehydration, blocking with hydrogen peroxide, sections were exposed to 10mM citrate buffer (PH 6.0) and heated at 95°C for 25 min in a water bath for antigen retrieval.
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PMC10522430
The treatment with GACP led to elevated levels of caspase-9 and caspase-3 compared to the control group.
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PMC11320834
Therefore, a phase II clinical trial is now underway .
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PMC11509224
This meroditerpene, 26-O-ethylstrongylophorine-14 (214, Figure 16), was isolated from the Caribbean marine sponge Strongylophora strongilata .
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PMC11461874
The cell lysates were immunoblotted using antibodies against DBP.
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PMC10578720
This process played an important role in inducing macrophage M2-like polarization.
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PMC11739504
Moreover, the proportion increased by approximately 2.5 times as ciliogenesis progressed.
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PMC10470467
CHMP7 and ESCRTIII can form a complex to jointly complete the contraction process, shear bud neck, and final membrane shedding (37).
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PMC10788478
LGR6 expression in lung cancer cell lines and surgical specimens was analyzed using quantitative RT‐PCR and immunohistochemistry.
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PMC9429973
The primary objective is complete response rate (CRR).
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PMC11760643
This pathway can be activated via three distinct pathways, which converge to form membrane attack complexes, which cause lysis of target cells .
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PMC11269792
p < 0.05.
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PMC11746948
Image in c, g, i shows representative results from three independent experiments.
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PMC7709199
Together, these examples suggest that the GD cell line can serve as a key option to obtain homogeneous samples of glycoproteins for structural studies, in particular for the improvement of the X-ray diffraction properties of N-glycosylated proteins.
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PMC9878562
Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis.
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PMC9927933
To understand the role of UBE2C/UBE2S E2 conjugating enzymes in the development of lung cancer, we first searched the cBioPortal database (https://www.cbioportal.org), which is generated largely based on The Cancer Genome Atlas (TCGA), to systematically analyze the genetic changes in the UBE2C and UBE2S genes in lung c...
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PMC11721587
This “hit and run” or catalytic mechanism allows one kinase to phosphorylate many substrates to rapidly amplify the signal.
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PMC10940855
Targeted inhibition of EFNB2 reverse signaling suppressed multiple myeloma survival and proliferation in vitro, increased sensitivity to chemotherapy and extinguished multiple myeloma growth in vivo.
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PMC10253973
The molecular docking into the HeLa human cervix carcinoma cell line revealed the potential application of the complexes as anticancer drugs.
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PMC9780037
Although this solution caused cyt c denaturation, at least 90% of cyt c structure and function were recovered after its removal from the protein .
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PMC11126803
Three independent assays were performed in triplicate in the above data.
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PMC7136814
Flow cytometry was performed using an 8-color Stratedigm (San Jose, CA) S1000EX apparatus.
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PMC11470381
Post-nucleofection RPMI medium ReagentFinal concentrationQuantity or VolumeRPMI 164040 mLFetal bovine serum20%10 mLSodium pyruvate (100×)1×500 µLMEM Non-essential amino acid (100×)1×500 µL * Filter final media using a 0.22 µm bottle-top vacuum filter system and store at 4 °C.
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PMC11499381
Detection and quantification of cell surface expression and mVenus fluorescence for CTR-based receptor complexes in transfected Cos7 cells. (
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PMC9429973
A trend towards shorter PFS among pts with CXCR4 genotype [estimated median PFS for 3.9 years (95% CI: 0.8-NR) vs 5.5 years (95% CI 5.3-NR) for pts with CXCR4 genotype, p=0.05, Figure 1B] was observed.
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PMC5600151
On the contrary, it reduced the leakage of drug from formulation .
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PMC8524093
In other words, the rate of C protein production is the determinant step for new virus assembly.
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PMC9370419
CCK-8 solution and culture media (no cells) were added to the blank control.
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PMC10142392
These results suggest that the crystallization properties of these PEG-b-(PHEMA-g-PCL) toothbrush-type copolymers can be easily adjusted depending on the number and length of the PCL segments (Figure 10).
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PMC11644761
So, given that our technique targets CpG islands, we conclude that mitochondrial DNA methylation contributes minimally to our findings, which are predominantly reflective of genomic DNA methylation.
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PMC11340319
The latest Census and city government data was used to determine population demographics for comparison.
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PMC11792888
Protein fractions responsible for the observed effect were identified using HPLC.
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PMC11380454
However, only a minor fraction of tumor cells that express PD-L1 respond to therapy 12.
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PMC10565698
Therefore, it is imperative to identify new biomarkers that may assist in the clinical diagnosis, treatment, and prognosis of LC.
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PMC11752740
Previous studies have highlighted that pistachio hulls contain significantly higher levels of phenolic compounds compared to the seeds, underscoring their importance due to their potent antioxidant properties .
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PMC11767725
For instance, engineered S. epidermidis strains, as described by Bousbaine et al. could be used in topical vaccines that stimulate robust immune responses without the need for systemic interventions.
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PMC11711345
However, the prediction against an NCI-60 tumor cell-line panel based on the Developmental Therapeutics Program’s NCI-60 data demonstrated a lower Pa of cuminaldehyde against MDA-MB-231 (0.20) at both 1 and 10 nM, which is reasonable with our findings (no antiproliferation in vitro).
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PMC11506670
The NRAS antibody used (rabbit α-NRAS polyclonal antibody, Cat.
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PMC9621239
Notably, the MYC protein, encoded by oncogene c-myc, was demonstrated to be a key mediator for the tumour-promoting effect of HBx-T81P/T101P/L123S.
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PMC11790599
The scale bar is 10 μm.
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PMC10907726
Data were expressed as means ± standard deviation (means ± SD).
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PMC11792090
To inhibit TCR expression, we knocked out the TCR-encoding gene TRAC using CRISPR/Cas9 technology, while the levels of HLA molecules were reduced by silencing B2M and HLA-DRA ( Figure 2A ).
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PMC9429973
Table 1) Results: After a median follow up of 27 months, at least one adverse event (AE) occurred in 68.3% patients, leading to treatment discontinuation in 23.3%.
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PMC9429973
BTM-3566 is active against a variety of B-cell malignancies but has the greatest effect in DLBCL, inducing robust therapeutic responses in vitro and in vivo.
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PMC11413393
e Normalized gene counts (DESeq2’s median of ratios normalization) for DNA damage proteins FANCM, BRCA2, RAD51AP1 and FANCD2 in RCC243 and 786-0 cells following 5μM MS023 treatment for 3 days (left, n = 2 technical replicates per cell line), and for RCC243 and 786-0 cells expressing PRMT1 targeting shRNAs treated with ...
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PMC11765243
Titer was considered as the reciprocal of the serum dilution yielding 50% of the maximal optical density.
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PMC11750696
Moreover, both preimmunization murine subjects with GRP78 protein (70) and administration of GRP78 molecules during arthritis progression (71) significantly mitigated the severity of disease along with upsurge of IL-4, IL-5, and IL-10, suggesting a causal role of GPR78 in RA pathology.
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PMC10747160
This Griffithsin-mediated cross-linking could, in turn, allow a single DC-SIGN receptor to capture and deliver clusters of multiple SARS-CoV-2 virions provided to susceptible cells.
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PMC10747160
These cells include following:HEK-293FT (Homo sapiens, embryonic kidney cells—a generous gift from Dr. David Gravano, University of California, Merced);HEK-293T cells expressing Human Angiotensin-converting Enzyme 2/hACE2 (Homo sapiens, embryonic kidney cells—obtained through BEI Resources, NIAID, NIH: Human Embryonic ...
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PMC11173119
Such cell platforms will be valuable for understanding the effects of the mutations on pyrin inflammasome dysfunction in FMF.
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PMC11730320
Patient Vδ2+ cells appear antigen-experienced like normal controls.
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PMC9220170
Application of 10 μM thapsigargin (TG), an inhibitor of the sarco/endoplasmic reticulum Ca ATPase (SERCA), in a calcium-free medium with the addition of 0.5 mM Ca-chelator EGTA, caused an increase in the concentration of cytosolic Ca ([Ca]i) in A-172 cells.
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PMC3203927
This event leads to the cells producing chemical signals (cytokines) for angiogenesis and is quite similar to the response occurring in normal hypoxic tissues where balanced signaling cascades lead to vascular remodeling and angioadaptation until the tissue oxygen concentration is back within its normal range .
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