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PMC11422497
Following a 5-week period, fluorescence imaging was conducted to visualize the subcutaneous xenografts in mice.
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PMC10158546
However, this system requires a steady supply of live animals, specialized equipment and a high level of technical expertise, reducing accessibility to researchers.
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PMC10728200
In summary, a valuable model for predicting recurrence in patients with GIST has been constructed.
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PMC11185260
RT-qPCR analysis of transcriptional expression of genes related to ATRT progression. *
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PMC11731614
Keratinocytes release a diverse population of extracellular vesicles.
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PMC11098378
siRNAs were designed against target sites that were at least 75 nts downstream of the initiation codon of each target gene, were 19 nts in length, and had a GC content of 35–55% .
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PMC9429973
We advocated better post-transplantation strategies to balance the risk of immunosuppression and viral reactivation for haplo-HSCT in AA patients.
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PMC11126803
Three independent assays were performed in triplicate in the above data.
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PMC11342785
The GFP-TPPP FL, GFP-TPPPCORE, and GFP-SynMAPs were mixed with unlabeled GMPCPP-stabilized MTs in the 1xBRB80 buffer for 5 min at room temperature.
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PMC11806818
This sandwich-type electrochemical sensor has a detection limit of 0.0071 ng/mL in the range of 0.01 − 100.0 ng/mL. This dual-signal sandwich-type aptamer biosensor based on nanozymes could provide new insights for clinically effective diagnosis of hepatocellular carcinoma (HCC).
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PMC11244823
All samples from Swiss horses and all but two samples from the Icelandic horses contained detectable levels of antibodies against gG4.
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PMC9429973
ABCB1 efflux activity was observed in a functional study when mitoxantrone accumulation increased as a direct consequence of midostaurin in CD34+ AML and patients with unachieved CR.
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PMC9429973
Moreover, th3 HSCs showed a reduced expression of mitochondrial biogenesis and mitophagy genes, thus suggesting an accumulation of damaged mitochondria.
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PMC9817179
The fact that different phase-separating proteins can have bifurcating behaviors upon fixation is interesting.
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PMC11610461
Specifically, the PSENEN-Notch signaling pathway plays an essential role in maintaining neural stem cells during cortical development (Cheng et al., 2019).
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PMC9261184
Lines represent the mean, and shaded areas represent 5th–95th percentile values across measured data.
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PMC11015054
The 80 patients in the immunohisto‐microarray were divided into high‐ and low‐expression groups.
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PMC10926885
In 11 tumours, we found a substantial correlation between HRD and NDE1, with 10 tumours (GBMLGG, LGG, LUAD, KIPAN, LIHC, MESO, PAAD, BLCA, ACC and KICH) showing a significant positive association and 1 tumour (TGCT) showing a significant negative association (Figure 6E).
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PMC5035325
These five patients illustrate the most frequent classes observed in our study.
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PMC9429973
Summary/Conclusion: Preliminary data from the PEPITE study show that TPO-RA are prescribed in early ITP, including 33% with pITP (18% with ITP 3-<6 m.) and are used in 7% of cases after splenectomy.
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PMC10165258
For all these different configurations, two steps of secondary droplet injection/fusion were performed because each secondary droplet came from a different library, generated in the aforementioned device.
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PMC6181431
However, these drugs are known to cause disease stabilization in most cases, with a 5% objective response rate by standard RECIST criteria.
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PMC9429973
Eight (42.1%) patients had risk organ involvement.
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PMC11463018
White solid, 70.8% yield.
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PMC11515150
It was exhibited that 5D and 12 C specifically bound to CD5-FL 293T cells and CD5-Trunc 293T cells.
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PMC11694066
The resulting 100 μL mix was gently homogenized and quickly transferred into a casting mold and incubated for 1 hour at 4°C to solidify.
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PMC11040965
C Densitometric analysis of the experiment shown in (B).
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PMC11075223
The structures mostly are dehydrated with xylose, glucose or arabinose to form monoglycoside, while disaccharides or trisaccharide glycosides are also present .
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PMC11665555
To determine the number of pathways, the topology analysis was done prioritizing “degree centrality”.
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PMC11742047
Afterwards, the data matrix was filtered by the presence of compounds in the blanks and by coefficient variation (CV), keeping only those signals that showed a coefficient variation of less than 20% in the QCs.
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PMC10798140
Compound 3e exhibited increased activity while maintaining adequate selectivity.
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PMC9429973
Results: A total of 26 eligible patients received CAR19/22 cocktail infusion with a median age of 46 years old (4-75) and a median of 3 prior lines of therapies (2-5 lines).
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PMC10878518
However, OBP-401-mediated GFP expression was not significantly increased in the benign group (Fig 4).
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PMC11730305
Evaluating the percentage of cell apoptosis showed that exposure of liver cancer cells to the NPs resulted in 28.1, and 9.16% of cells undergoing cell necrosis and apoptosis, respectively.
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PMC11621565
Fig. 5QRT-PCR for α-synuclein mRNA performed 48 h after treatment with bacterial compounds (curli CsgA 16 µg/ml, PSMα1 16 µg/ml, LPS 1 µg/ml, 32 µg/ml and 64 µg/ml, rhamnolipid 10 µg/ml, 40 µg/ml and 80 ug/ml) on dopaminergic-differentiated SH-SY5Y cells.
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PMC11257988
Similar OS and PFS among KRAS and KRAS-wtOS(month)46.537.1Cai et al. 1126 (advanced stage)KRAS(G12C) 24NAPemetrexed + platinumPFS(month)15.57NAThe PFS and OS of patients with KRASG12D mutation were inferior to those with KRASG12C mutation or KRASG12V mutation.
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PMC9250505
Cells were incubated with primary antibodies overnight.
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PMC11740399
Annexin V/PI staining (E) supported combination therapy enhances the percentage of cell apoptosis. (
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PMC11656048
One major finding of this study is our elucidation of the mechanism underlying the shikonin on anti-proliferation of OS cells.
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PMC9712534
Thus, TOP2 poisons exhibit anti-proliferating activity and are used for cancer therapy.
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PMC11144200
To assess the effectiveness of RGD-mediated cellular absorption of LPS-RGD-Nb36-DOX, fluorescence microscopy was used.
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PMC11705862
The following complexes were assessed: VAMP2 and SNAP-25 (E with quantification in F), VAMP2 and Syntaxin1 (G with quantification in H), Syntaxin 1 and SNAP-25 (I with quantification in J).
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PMC6771295
Analysis of sirtuin family members crosstalk revealed that SIRT1 has negative effect on SIRT3 and SIRT5 protein levels in bone cells (Figure 2A) and this depends on the type of cellular stress, whereas positive effects were recorded in Mero-14 mesothelioma cells (Figure 2B).
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PMC11401358
To determine the SF antioxidant potential at the molecular level, we performed RNA-seq analysis of three groups of NIH3T3 cells, including the phosphate-buffered saline (PBS) only group, the H2O2 treated group, and both the H2O2 and SF treated groups (named SF group) (Fig. 3B).
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PMC11453018
Principal Component Analysis (PCA) revealed a clear trend: while different ES cell lines clustered together in the control set, they were distinctly separated in the iP300w-treated groups, highlighting the substantial impact of iP300w treatment on cell transcriptomes (Supplementary Fig. 3A, B).
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PMC4485786
Consistent with SCT of human patients with RMS, the immune system failed to reject the allogeneic A204.
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PMC3734024
B cells cultured with IL-5 and CD40L Fb showed higher surface expression of FasL, CD5, and CD1d (Figure 5D and 5E), and were significantly enriched for FasL B cells (Figure 5F).
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PMC8358006
Spearman correlation coefficients.
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PMC9429973
Aims: To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of cevostamab-containing combination regimens (Arm B: cevostamab plus P and dexamethasone [d] [Pd]; Arm C: cevostamab plus Dd) in patients with R/R MM.
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PMC10890055
Also, the availability of Zn in media can differ.
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PMC9429973
MPN patients receiving the BNT162b2 vaccine had higher anti-S IgG and neutralising antibody levels compared with those receiving ChAdOx-1 (p=0.05/p=0.04).
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PMC7171147
e A proposed mechanism underlying COL11A1-induced cisplatin resistance in ovarian cancer.
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PMC11742670
A review by Selvaraj et al. has been made to discuss different algorithms and tools for predicting the target in repurposing a drug.
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PMC10578720
By using a TLR2 agonist and inhibitor, we further confirmed that HBV could downregulate SIRT3 expression by means of the TLR2-NF-κB-PGC-1α axis, which accounts for the hyperacetylation of CS and PDHC in macrophages induced by HBV.
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PMC11087766
DAPI-stained wild-type P. aeruginosa cells infected with wild-type or PicA T367P mutant PhiKZ at 30 mpi with quantification of nuclear area for cells infected with wild-type or PicA T367P mutant PhiKZ imaged.
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PMC10831439
IL-2, TNF-α, sFasL, IFN-γ, granzyme A and granzyme B release by CD19-CAR-iNKT cells on contact with modified Raji-PD-L1 (left) and Raji-PD-L2 cells (right, n=3).
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PMC9429973
At a median follow-up of 27 months, PET-negative vs. PET-positive patients at EOT had a 2-yr OS of 72% vs. 52% [HR 0.58; 95% CI 0.24–1.41), p=0.231] and 2-yr PFS of 55% and 29% [HR 0.45 (95% CI 0.23–0.88), p=0.021] respectively.
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PMC11248911
C NMR (DMSO-d6, δ ppm): 15.80, 46.23, 67.36, 128.22, 128.26, 128.62, 129.41, 131.60, 135.49, 139.26, 140.75, 150.46.
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PMC11001582
Following nucleofection, 100 µl of cell suspension was plated in each well (total of six wells per cuvette) of a glass-bottom or plastic 24-well plate for propidium iodide (PI) and Alamar Blue toxicity and viability experiments, respectively.
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PMC11352877
At the same time, ANG1 is widely expressed by cells, and in the endometrium, it is mainly expressed in the stroma surrounding blood vessels in the secretory phase of the cycle .
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PMC11247842
Such an effort is not frequent in livestock, but there are a few studies, e.g. meta-analysis of cattle stature , milk fat and protein percentage , and feed efficiency , and multi-trait analysis of various production traits and meat quality traits .
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PMC11087055
In amniotes, mitosis is required for PS morphogenesis, and expanding the mass of the PS cells contributes to the maintenance of the polonaise movements (Figure 2).
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PMC8956657
HB number of hydrogen bonds, SB number of salt bridges, NHB number of non-hydrogen bonds generated in PDBsum, BSA buried surface area calculated in PISA.
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PMC11285179
Retinoic acid (RA), also known as vitamin A acid, and its related analogs participate in regulating the gene networks involved in cell growth, differentiation, homeostasis, and apoptosis.
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PMC10114490
Our cells expressed high levels of albumin and alpha-1 antitrypsin (Fig. 4A) and stored glycogen in the cytoplasm (Fig. 4B).
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PMC11638255
Consistent with these results, we observed a marginal increase in migratory capacity towards SK-N-BE(2)-C cells when pre-treated with TEPA, supporting our previous in vivo observations (Fig. 6i).
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PMC11472569
Additionally, factors such as low pH, hypoxia, and increased external pressure can promote EV release.
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PMC11615101
The bar graph showing IL-6 concentration in rat’s plasma sample measured by ELISA, found downregulated in the knockdown group. (
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PMC5810978
These cultures were incubated for 3 days and then frozen and thawed for three cycles.
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PMC11476666
In MP spheroids, both CD44 and SOX2 protein levels were significantly reduced after treatment with both stilbenes in pre- and postformation culture (Figure 8d–f).
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PMC11755467
CEM-SS cells were cultivated in biological triplicates for 3 days in a 96-well plate (seeding density 20,000 cells per well) in 0, 10, 50 150 and 300 µM of Enoxacin, nalidixic acid or the respective volumes of DMSO negative control.
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PMC11657744
In contrast, our study demonstrates that while CEP89 is not required for ciliogenesis in MEFs, it does contribute to ciliary disassembly, pointing to a novel, distinct function of CEP89 in regulating ciliary resorption dynamics.
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PMC11792766
Effect of food simulants and organic solvents on the frequency of binucleated exposed HepG2 (a) and Caco‐2 (b) cell lines as assessed via the in vitro micronucleus assay.
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PMC11715644
We plotted average metrics for cell morphology across samples and found that cell area for WT and +RhoA cells was lower than +ErbB2 (Fig. 5E), further indicating the need for non-cancer cells to get squeezed to enter confinement.
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PMC11310713
All rats were bred and housed in a controlled setting under specific pathogen-free conditions.
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PMC9954564
Single best models were selected from each of the two-marker and three-marker combinations.
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PMC11791203
Sl.
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PMC11206251
On the other hand, Bcl-2 plays a tumor suppressor role in the mitochondrial apoptosis pathway by blocking the pro-apoptotic effect of Bax.
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PMC9429973
According to the established criteria, all subjects were divided into groups with high (+) [≥9% for p16; ≥35% for p53] and low (-) [<9% for p16; <35% for p53] protein expression.
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PMC5363531
Each experiment was performed in duplicate.
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PMC7961460
Results showed peptides that matched for the c10orf118 protein (see Supplementary Figure S1A,B).
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PMC7504302
We further extended the analysis and investigated the mutational status of these genes in the TCGA dataset of 87 MPM cases.
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PMC11730000
The membrane was placed with appropriate primary antibodies anti-mTOR (1:1000 dilution; Cell Signaling, Germany) overnight at 4 °C.
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PMC9429973
No dose-limiting toxicities were observed in any dose group, and all adverse events were reversible after proper management.
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PMC8759873
P < 0.05 was considered to be significant and statistically significant.
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PMC11574029
Data are presented as the mean ± SEM of three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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PMC11650848
Cognitive assessments were administered at ages 3, 7 and 11 years as described in detail elsewhere .
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PMC11674146
PI3Ks constitute a lipid kinase family with the characterization of their capability to phosphorylate inositol 3′-OH group in inositol phospholipids, which can phosphorylate phosphatidylinositol-4,5-bisphosphate (PIP2) for the generation of PIP3 (Fresno Vara et al., 2004; He et al., 2021).
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PMC11678130
5-Fluorouracil (5-FU), a pyrimidine analog and antimetabolite that impedes DNA synthesis, halts cancer cell proliferation, and induces apoptosis, has emerged as a primary choice in combating skin malignancies, being included as an active ingredient in conventional local formulations (e.g., Efudex, Fluoroplex, Carac, Ef...
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PMC11087055
Axes as in Figure 1. (
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PMC9429973
At these time points, patient-reported HRQoL and fatigue were also assessed with the FACT-G and PROMIS-Fatigue questionnaires (via paper copies), respectively.
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PMC9874064
Kun Shang: Data curation, Writing – original draft.
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PMC11747467
Data are presented as the mean ± SD. (
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PMC10048572
Subclones were obtained by limiting dilutions.
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PMC10823017
Subsequently, the supernatant was removed, and the cell pellets were collected.
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PMC11413393
GO biological process and molecular function pathway enrichment analysis of the common list revealed that the majority of identified PRMT1 interactors are proteins involved in RNA metabolism and processing (Fig. 7b).
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PMC9429973
Methods: We performed single-cell RNA sequencing (scRNA-seq) of T cells and hematopoietic stem and progenitor cells (HSPCs) isolated from BM aspirates 100 days post alloSCT of three patients in complete remission (CR) versus three suffering relapse (REL).
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PMC9429973
And extracted from electronic medical records.
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PMC11626627
Moreover, its direct role in regulating tumor cell behavior as a target gene, TWIST1 has been shown to interact with other TFs to modulate gene expression through TF/co-regulator-mediated pathways .
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PMC11755467
To perform chemical probing, as the first step, pre-miR-132 was re-folded (15 pmol in ddH2O) by heating it up at 95 °C for 2 min and snap cooling on ice, again for 2 min.
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