OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	A new treatment with rFVIIa was started.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "new", "treatment", "with", "rFVIIa", "was", "started", "." ] } ]
PMC10079526	P-value * ≤ 0.05.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "P-value", "*", "≤", "0.05", "." ] } ]
PMC9884169	It has been reported that MCT4 mainly affects intracellular ROS levels and oxidative stress .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "reported", "that", "MCT4", "mainly", "affec...
PMC11782508	Notably, specific peaks at δ 0.075 ppm and δ 3.40 ppm were assigned to the side chains of methionine (Met121) and cysteine (Cys112), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Compared with individuals not administered anti-lymphoma treatment or administered less than 3 cycles anti-lymphoma therapy, those who received standardized anti-lymphoma therapy (≥3 cycles) showed improved PFS (p=0.0006) and OS (p<0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	Panel f: Venn diagram showing the number of shared and tissue-specific DEGs (LY3300054 vs human IgG treatment) across various tissue types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11753949	As shown previously, expression of this chimera in COS-7 cells resulted in the formation of elongated inclusions (Figure 5B–D) that were positive for actin - as shown by phalloidin staining (Figure 5D)- and bore a resemblance to those induced in the cell bodies of neurons (Figure 1C) and COS-7 cells (Figure 2A) by syna...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, HSCs decrease their regenerative potential and undergo toward a myeloid-biased fate skewing with age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "HSCs", "decrease", "their", "regenerat...
PMC9895440	transfer of 1 Mio human CD8+ CD28 KO anti-CD19-BBz CAR T cells with or without SNX9 KO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "transfer", "of", "1", "Mio", "human", ...
PMC11740508	As expected, at the SUM149PT IC50 doses, the BRCA1 and BRCA2-targeted M231 cells were more sensitive to talazoparib than M231 cells (Fig. 1B–D) final population sizes: M231 Tala treated were 74% of controls versus M231 ~ 48%, and M231 33%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...
PMC6643347	Recent data indicate that Th17 cells producing interleukin 17 (IL-17) exhibit maximum susceptibility to the HIV infection and are, therefore, prone to rapid depletion .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11618052	0.58 (hexane : ethyl acetate, 1 : 2, v/v).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "0.58", "(", "hexane", ":", "ethyl", "acetate", ",", "1", ":", "...
PMC8357004	In the current study, we reported that 5-Aza-CdR and TSA can inhibit Caco-2 cell growth and induce apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "current", "...
PMC9429973	In this xenogeneic model of GVHD, hemoglobin levels and platelet numbers in blood were both reduced, indicating anemia and thrombocytopenia, respectively, which are two complications associated with aplastic anemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9243326	First, we used non-full-length reads to polish the obtained cluster consensus Unigenes with the Quiver software to produce FL, polished, high-quality consensus sequences (accuracy of ≥99%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9777812	After blocking with 5% skim milk powder solution for 1 h at 37 °C, the membranes were incubated overnight at 4 °C with a murine polyclonal rabbit antibody against CDKN1A, STAT5, p-STAT5, PI3K, AKT1, p-AKT1, mTOR, p-mTOR, and CSN2 (Santa Cruz, CA, USA), and then incubated with the horseradish peroxidase (HRP)-conjugated...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765678	Erastin exhibited hydrogen bonding with S596 and Q141 and hydrophobic interactions with L539 and V534 in BCRP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Erastin", "exhibited", "hydrogen", "bonding", "wi...
PMC9966931	Enzymatic synthesis of the six hybrid molecules was carried out using Novozym 435 as a biocatalyst.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enzymatic", "synthesis", "of", "the", "six", "hybrid",...
PMC9429973	Time to NP was assessed using the Kaplan-Meier estimation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Time", "to", "NP", "was", "assessed", "using", "the", "Kaplan-Meier", "estimation", "." ] } ]
PMC8956657	NLS nuclear localization signal, PDE phosphodiesterase domain, MERS Middle East respiratory syndrome-related coronavirus, IMPα importin alpha, α importin alpha, RLR RIG-I-like receptor, TLR Toll-like receptor, NF-κB Nuclear factor kappa light chain enhancer of activated B cells, IFN interferon, GAPDH Glyceraldehyde 3-p...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508	These findings contribute to our understanding of the role of PAX gene expression in RCC, and they may help guide future studies to improve treatment outcomes for RCC patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8567602	H, Graph of the fraction of tumors by each induction method demonstrating each of the histologic features (TATCre + Smarcb1/fl, n = 11; Myf5Cre;Smarcb1/fl, n = 8; TATCre + hSS2, n = 15; Myf5Cre;hSS2, n = 17; TATCre + hSS2;Smarcb1/fl, n = 13; Myf5Cre;hSS2;Smarcb1/fl, n = 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients were classified by International Myeloma Working Group (IMWG) response criteria as a clinical correlate of therapy response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", "classifi...
PMC11764090	When plants are subjected to cold stress, intracellular JA concentration increases, and JA-lle is transported to the nucleus through the JAZ1 protein, promoting the interaction of JAZ with the E3–ubiquitin ligase–SCF complex and the COI1 receptor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	In this study, we verified for the first time that UVB irradiation simultaneously upregulated indicators of pyroptosis, apoptosis and necroptosis in keratinocytes both in vivo and ex vivo, indicating that PANoptosis may be triggered in UVB-challenged keratinocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Some studies support that the presence of more than 50% and less than 15% of erythroid precursors (EPs) in bone marrow (BM) is a poor prognostic factor in MDS for long-term outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9080589	Differences between two groups were analyzed by Student's t test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differences", "between", "two", "groups", "were", "analyzed", "by", "Student", "'s", ...
PMC11711063	The shift in cell shape induced by ZG16B was reminiscent of a phenotype produced by TGFβ‐treatment, consistent with epithelial‐mesenchymal transition (EMT), and a change in cell–cell adhesion and motility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10506676	2x Master Mix Green (Ampliqon Inc., Denmark), cDNA, primers (at a concentration of 10 pmol), and water made up the final volume of each reaction, which was 15 µL. For the PCR program, a denaturation phase of 95 °C lasting 15 minutes was followed by 40 cycles of 95 °C for 15 seconds and annealing/extension at 62 °C for ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	By univariate analysis, patients with lower Vγ9Vδ2 T cells at diagnosis had significantly lower 5-year OS and RFS (HR = 1.54, 95%CI = 1.03-2.31, p = 0.028 and HR = 1.69, 95%CI = 1.09-2.62, p = 0.015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7724160	Size Exclusion Chromatography (SEC) data for the antibodies produced which allowed for the identification of high and low molecular weight species in the samples (N-Glycan and SEC data was taken on day 14 only).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Age- and sex-matched patients with advanced solid cancers and those with impaired oral intake and/or poor venous access treated with HDC served as controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11139449	GraphPad Prism version 8.0 for Windows (GraphPad Software, USA) was used, and the data were represented as mean ± S.E. The cloning of normal gRNAs in PX459 resulted in a PCR product with a length of 300 bp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502066	Gαs-coupled GPCRs stimulate adenylyl cyclase converting ATP into cyclic adenosine monophosphate (cAMP), whereas Gαi-coupled GPCRs block adenylyl cyclase and the formation of cAMP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11680391	We then constructed a linear regression model to identify factors affecting the dependent variable BTSCC: BTSCC~Agreement construct + herd size The questions for the dairy farmer and herd veterinarian were transformed into the defined constructs, and the allocation of the questions to each construct was carried out bef...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	This study highlights the importance of OTULIN in OS chemoresistance and provides a promising approach for targeting the OTULIN-GPX4 axis to improve the prognosis of OS patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591038	For example, FGF21 lessened tau hyperphosphorylation and oxidative stress in cellular and rat models of AD; its beneficial effects involved the inhibition of the PP2A/MAPKs/HIF-1α pathway (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the expansion phase, up to 14 pts at the selected safe and pharmacologically active dose/s will be enrolled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "expansion", ...
PMC11126803	B, tumor average photons for ccRCC from xenograft mice described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "tumor", "average", "photons", "for", "ccRCC", "from", "xenograft", ...
PMC11650848	Blood DNA methylation was used as a control comparison (grey bar).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blood", "DNA", "methylation", "was", "used", "as", "a", "control", "c...
PMC9429973	Results: We found DAC combined with APR-246 had a synergistic effect on tumor cells with TP53 mutation in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "...
PMC9429973	The manufacturer’s protocol recommends a twice-weekly dosing schedule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "manufacturer", "’s", "protocol", "recommends", "a", "twice-weekly", "dosing", "schedule", "." ] ...
PMC11718809	Most circRNAs act as miRNA sponges, inhibiting miRNAs’ regulatory effects on target genes and thereby influencing target gene expression levels .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "circ...
PMC8750422	Furthermore, GPR87 overexpression promotes cancer cell growth and metastasis by upregulating CD133-positive cancer stem-like cells in liver cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "GPR87", "over...
PMC9436459	In TNF-α-stimulated HeLa cells, kuwanon J 2,4,10"-trimethyl ether (82) and kuwanon R (86) strongly inhibited NF-κB activity with the IC50 values of 4.65 and 7.38 μM, respectively .	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	We further constructed a xenograft tumor model in mice using control and ERBB2 overexpression T24 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "We", "further", "constructed", "a", "xenograft", ...
PMC9429973	Clinical and laboratory data regarding patients with HC under palliative care who have been hospitalized and treated with HDC (BD SAF-T-Intima®, Braun) was collected through the medical chart review.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11751675	The data supporting this article have been included in the main manuscript.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "supporting", "this", "article", "have", "been", "included", "in",...
PMC10174970	In pan-function analysis, the cell line showing the highest genetic correlation to patient tumors was Panc 03.27 for PAAD cell lines from primary lesion sites and Capan-1 for PAAD cell lines from metastatic lesion sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	It is essential that patients referred for HSCT undergo a thorough dental assessment and are deemed “dentally-fit” prior to transplant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", ...
PMC10507284	E–N) The IC50 of AZD0530, nilotinib, erlotinib, lapatinib, AZD6244, PD‐0325901, nutlin‐3, paclitaxel, PD‐0332991, and PLX4720 between low (n = 131) and high (n = 132) TROAP expression subpopulations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8839885	This assay utilizes an antibody that recognizes only the cleaved PARP protein from human origin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "assay", "utilizes", "an", "antibody", "that", "reco...
PMC11429241	On the other hand, the A2780 cell line showed substantial changes in gene expression when it was grown on spheroid scaffolds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", ...
PMC2118063	Expression of IRF4 in B cells is regulated primarily by pathways known to drive lymphocyte activation rather than by IFN, which is the case for most other IRF family members.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8469018	DHODH converts L-dihydroorotate (DHO) to orotate (ORO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DHODH", "converts", "L-dihydroorotate", "(", "DHO", ")", "to", "orotate", "(", "ORO",...
PMC9917080	We have previously shown that the application of selenium nanoparticles, as well as the selenium and sorafenib nanocomplex, caused the generation of Ca responses in HepG2 hepatocellular carcinoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721096	C. arabica possesses various health benefits that prevent cardiovascular disease, type 2 diabetes, Parkinson’s disease, and Alzheimer’s disease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", ...
PMC11611077	The average area and intensity in each clone are shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "area", "and", "intensity", "in", "each", "clone", "...
PMC11706491	High expression levels of fluorescent proteins may impose metabolic burdens on cells or perturb endogenous signaling pathways, leading to unintended effects on cell behavior.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11739484	Additionally, MMPs modulate immune responses within the tumor microenvironment, creating an immunosuppressive milieu that facilitates immune evasion and tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ...
PMC11792888	MRC-5 has helped to determine safe concentration ranges for these drugs and their combination .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MRC-5", "has", "helped", "to", "determine", "safe", "concentration", ...
PMC11641532	Moreover, we conducted both in vitro and in vivo validations to confirm the functional role of HSD3B7 in ccRCC progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC11064533	COG functions/categories were considered significantly upregulated/downregulated if Benjamini-Hochberg corrected P value was equal to or lower than 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COG", "functions/categories", "were", "consi...
PMC9429973	Approximately 880 patients are planned to be randomized at approximately 350 centers in North and South America, Europe, and Asia-Pacific.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", ...
PMC5363531	All experiment was performed at least in duplicate for tree times, each firefly luciferase signal was normalized by renilla luciferase and the normalized values was relativized to pcDNA transfection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	LNP colocalization with the endosomal compartments suggest that the TatDE LNPs travel through the endosomal compartments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LNP", "colocalization", "with", "the", "endosomal", "c...
PMC10380508	The relationship between the expression level of PAX genes and patient survival in different RCC subtypes was analyzed by GEPIA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relationship", "betwe...
PMC11621493	MMAT assays revealed that the enzyme has no strict positional and FA preferences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MMAT", "assays", "revealed", "that", "the", "enzyme", "has", "no", "s...
PMC11635519	Representation of the interactions of the PepA’s N-terminal residue with the receptor binding site in the most representative cluster. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representation", "of", ...
PMC10380508	For the MTT assay, cell transfections/manipulations were performed in duplicate in a 96-well plate format.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "MTT", "assay", ",", "cell", "trans...
PMC11806106	With this cell line, we conducted FRET measurements in a 96-well microtiter plate configuration using a plate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "this", "cell", "line", ...
PMC11678368	and it decreases slightly to 4.22 kcal/mol after ZPE correction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "and", "it", "decreases", "slightly", "to", "4.22", "kcal/mol", "after", "ZPE", "correction", ...
PMC11721064	In contrast, ΔNP63α expression was very faint in the central corneal epithelium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "ΔNP63α", "expression", "was", "very", "faint", ...
PMC9429973	Methods: The primary endpoint of the trial is progression-free survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "The", "primary", "endpoint", "of", "the", "trial", "is", "progression...
PMC11597291	The red blood cells (RBC, erythrocytes) were washed thrice with normal saline and a ratio of 1:20 pure RBC was prepared at a final volume of 2 mL. The nCGO and nCGO-PEG particles were prepared in PBS for concentrations in the range of 0.5 μg/mL to 1000 μg/mL. Then, equal quantities of RBC and particles were mixed with ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11610461	Metformin stimulates PSENEN to bind to the ATP6AP1 subunit and inhibits lysosomal proton pump v-ATPase activity, resulting in the activation of the AMPK pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Among pts who successfully collected ≥2×10/Kg CD34 (n=287, 95%), 34 (12%) required PLX: 23 (68%) due to a CD34/uL count ≤20 after ≥4 days of G-CSF and 11 (32%) to a collection <1×10/Kg after the first apheresis day.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786704	Then all mice were fed normally.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "all", "mice", "were", "fed", "normally", "." ] } ]
PMC11794847	A: Flow cytometry histograms illustrating the increased rate of apoptosis in T cells after the silencing of HVEM, indicating its potential role in T cell survival; B: Western blot analysis confirming T cell apoptosis post-HVEM knockdown; C: Graphical representation of T cell activation markers measured by flow cytometr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	of Hypermutated Clones/Total Clones Sequenced (%)Average G-to-A Mutations/Hypermutated CloneDinucleotide Context of G-to-A MutationsTotal G-to-A MutationsTotal G-to-A Mutations/Total Clones SequencedGGGAGCGTA3G(DK)−52/52 (100%)40.31,85122747862,11640.7+40/60 (66.7%)18.56784461073812.3A33G(DK)−28/55 (50.9%)13.1319163834...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6024716	The previous report by Xiao et al. also showed that improved expression by addition of external polyamines is concentration-dependent up to an optimal concentration, above which higher concentrations have negative effects on the expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782508	Cells treated with the IC₅₀ concentration of purified azurin. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "treated", "with", "the", "IC₅₀", "concentration", "of", "purified", "azurin", ".", ...
PMC5839394	Protein spots were quantified, normalized and inter-gel matched and only differentially expressed proteins with the threshold settings with at least fold change ≥ 1.3 and p-value < 0.01, were considered regulated (Supplementary Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	The upregulation of CHOP remained even after 24 h of TG and PF treatment (Supplementary Fig. S12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "upregulation", "of", "CHOP...
PMC9429973	The tipping values of Ret percentage, ALC and RDW-CV were 0.45%, 1.06×10/L and 11.75%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tippi...
PMC7504302	Three of those MPM cell lines showed very high sensitivity to PD-173074, an FGFR1 and FGFR3 kinase inhibitor (FGFRi).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "of"...
PMC11228511	SMCs expressing GFP with a nuclear localization signal (nls-GFP) have been described previously (21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SMCs", "expressing", "GFP", "with", "a...
PMC10522430	The prevention of NF-κB activation has become a significant focus in the field of cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prevention", "of", "NF-κB", "activation", "has"...
PMC6835428	A drawback of KURAMOCHI, however, is linked to the difficulties of its grafting into xenograft mouse models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "drawback", "of", "KURAMOCHI"...
PMC11201989	The primary cilium is a microtubule-based structure that extends from the apical surface of most eukaryotic cells and functions as a sensory organelle, sensing and transducing environmental cues through ciliary sensory receptors, such as the polycystins .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	Membrane penetration by non-enveloped viruses is diverse and generally not well understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Membrane", "penetration", "by", "non-enveloped", "viruses", "is", "diverse", "and", ...
PMC11033180	The number of synapsin 1 clusters was normalized to β3-tubulin area.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "synapsin", "1", "clusters", "was", "normalized", "to", "β3-tub...
PMC11127909	This effect could maintain mitochondrial function, thereby favoring OS cell survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "could", "maintain", "mitochondrial", "function", ",", "thereby", ...
PMC5673060	Biological function analysis of PazR versus A204 parental cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Biological", "function", "analysis", "of", "PazR", "versus", "A204", "parental", "cells", ".", ...
PMC11634027	Statistical tests for graphs showing wing area, roundness, and relative cross-vein distance were determined by one-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "tests", "for", "gr...
PMC3122064	In the present study, we have used a panel of cisplatin-sensitive and -resistant wild-type p53 expressing TC cell lines to compare cisplatin responses (Table 1) with the cellular localisation of p53 and MDM2, and MDM2-p53 complex formation (Figures 1a–c, Supplementary Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534035	The pathway by which GPER1 influences PAI1 expression has not yet been fully understood and warrants further investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pathway", "by", "which", "GPER1...
PMC11344246	Changes in cell viability for each cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Changes", "in", "cell", "viability", "for", "each", "cell", "line", "." ] } ]
PMC5415764	The P-gp expression of A2780 or A2780/PTX cells after pretreatment with various formulations was detected by flow cytometry analysis (Fig. 4A).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8343815	At passage 3 of the cell culture process, 103 cells were counted by hemocytometer, seeded onto a 96-well plate, and incubated for 12 hours to adhere.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

A new treatment with rFVIIa was started.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "new", "treatment", "with", "rFVIIa", "was", "started", "." ] } ]

PMC10079526

P-value * ≤ 0.05.

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "P-value", "*", "≤", "0.05", "." ] } ]

PMC9884169

It has been reported that MCT4 mainly affects intracellular ROS levels and oxidative stress .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "reported", "that", "MCT4", "mainly", "affec...

PMC11782508

Notably, specific peaks at δ 0.075 ppm and δ 3.40 ppm were assigned to the side chains of methionine (Met121) and cysteine (Cys112), respectively.

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PMC9429973

Compared with individuals not administered anti-lymphoma treatment or administered less than 3 cycles anti-lymphoma therapy, those who received standardized anti-lymphoma therapy (≥3 cycles) showed improved PFS (p=0.0006) and OS (p<0.0001).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5925824

Panel f: Venn diagram showing the number of shared and tissue-specific DEGs (LY3300054 vs human IgG treatment) across various tissue types.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11753949

As shown previously, expression of this chimera in COS-7 cells resulted in the formation of elongated inclusions (Figure 5B–D) that were positive for actin - as shown by phalloidin staining (Figure 5D)- and bore a resemblance to those induced in the cell bodies of neurons (Figure 1C) and COS-7 cells (Figure 2A) by syna...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

However, HSCs decrease their regenerative potential and undergo toward a myeloid-biased fate skewing with age.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "HSCs", "decrease", "their", "regenerat...

PMC9895440

transfer of 1 Mio human CD8+ CD28 KO anti-CD19-BBz CAR T cells with or without SNX9 KO.

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PMC11740508

As expected, at the SUM149PT IC50 doses, the BRCA1 and BRCA2-targeted M231 cells were more sensitive to talazoparib than M231 cells (Fig. 1B–D) final population sizes: M231 Tala treated were 74% of controls versus M231 ~ 48%, and M231 33%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...

PMC6643347

Recent data indicate that Th17 cells producing interleukin 17 (IL-17) exhibit maximum susceptibility to the HIV infection and are, therefore, prone to rapid depletion .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11618052

0.58 (hexane : ethyl acetate, 1 : 2, v/v).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "0.58", "(", "hexane", ":", "ethyl", "acetate", ",", "1", ":", "...

PMC8357004

In the current study, we reported that 5-Aza-CdR and TSA can inhibit Caco-2 cell growth and induce apoptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "current", "...

PMC9429973

In this xenogeneic model of GVHD, hemoglobin levels and platelet numbers in blood were both reduced, indicating anemia and thrombocytopenia, respectively, which are two complications associated with aplastic anemia.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9243326

First, we used non-full-length reads to polish the obtained cluster consensus Unigenes with the Quiver software to produce FL, polished, high-quality consensus sequences (accuracy of ≥99%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9777812

After blocking with 5% skim milk powder solution for 1 h at 37 °C, the membranes were incubated overnight at 4 °C with a murine polyclonal rabbit antibody against CDKN1A, STAT5, p-STAT5, PI3K, AKT1, p-AKT1, mTOR, p-mTOR, and CSN2 (Santa Cruz, CA, USA), and then incubated with the horseradish peroxidase (HRP)-conjugated...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11765678

Erastin exhibited hydrogen bonding with S596 and Q141 and hydrophobic interactions with L539 and V534 in BCRP.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Erastin", "exhibited", "hydrogen", "bonding", "wi...

PMC9966931

Enzymatic synthesis of the six hybrid molecules was carried out using Novozym 435 as a biocatalyst.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enzymatic", "synthesis", "of", "the", "six", "hybrid",...

PMC9429973

Time to NP was assessed using the Kaplan-Meier estimation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Time", "to", "NP", "was", "assessed", "using", "the", "Kaplan-Meier", "estimation", "." ] } ]

PMC8956657

NLS nuclear localization signal, PDE phosphodiesterase domain, MERS Middle East respiratory syndrome-related coronavirus, IMPα importin alpha, α importin alpha, RLR RIG-I-like receptor, TLR Toll-like receptor, NF-κB Nuclear factor kappa light chain enhancer of activated B cells, IFN interferon, GAPDH Glyceraldehyde 3-p...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10380508

These findings contribute to our understanding of the role of PAX gene expression in RCC, and they may help guide future studies to improve treatment outcomes for RCC patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8567602

H, Graph of the fraction of tumors by each induction method demonstrating each of the histologic features (TATCre + Smarcb1/fl, n = 11; Myf5Cre;Smarcb1/fl, n = 8; TATCre + hSS2, n = 15; Myf5Cre;hSS2, n = 17; TATCre + hSS2;Smarcb1/fl, n = 13; Myf5Cre;hSS2;Smarcb1/fl, n = 8).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Patients were classified by International Myeloma Working Group (IMWG) response criteria as a clinical correlate of therapy response.

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PMC11764090

When plants are subjected to cold stress, intracellular JA concentration increases, and JA-lle is transported to the nucleus through the JAZ1 protein, promoting the interaction of JAZ with the E3–ubiquitin ligase–SCF complex and the COI1 receptor .

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PMC11762280

In this study, we verified for the first time that UVB irradiation simultaneously upregulated indicators of pyroptosis, apoptosis and necroptosis in keratinocytes both in vivo and ex vivo, indicating that PANoptosis may be triggered in UVB-challenged keratinocytes.

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PMC9429973

Some studies support that the presence of more than 50% and less than 15% of erythroid precursors (EPs) in bone marrow (BM) is a poor prognostic factor in MDS for long-term outcomes.

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PMC9080589

Differences between two groups were analyzed by Student's t test.

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PMC11711063

The shift in cell shape induced by ZG16B was reminiscent of a phenotype produced by TGFβ‐treatment, consistent with epithelial‐mesenchymal transition (EMT), and a change in cell–cell adhesion and motility.

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PMC10506676

2x Master Mix Green (Ampliqon Inc., Denmark), cDNA, primers (at a concentration of 10 pmol), and water made up the final volume of each reaction, which was 15 µL. For the PCR program, a denaturation phase of 95 °C lasting 15 minutes was followed by 40 cycles of 95 °C for 15 seconds and annealing/extension at 62 °C for ...

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PMC9429973

By univariate analysis, patients with lower Vγ9Vδ2 T cells at diagnosis had significantly lower 5-year OS and RFS (HR = 1.54, 95%CI = 1.03-2.31, p = 0.028 and HR = 1.69, 95%CI = 1.09-2.62, p = 0.015).

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PMC7724160

Size Exclusion Chromatography (SEC) data for the antibodies produced which allowed for the identification of high and low molecular weight species in the samples (N-Glycan and SEC data was taken on day 14 only).

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PMC9429973

Age- and sex-matched patients with advanced solid cancers and those with impaired oral intake and/or poor venous access treated with HDC served as controls.

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PMC11139449

GraphPad Prism version 8.0 for Windows (GraphPad Software, USA) was used, and the data were represented as mean ± S.E. The cloning of normal gRNAs in PX459 resulted in a PCR product with a length of 300 bp.

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PMC11502066

Gαs-coupled GPCRs stimulate adenylyl cyclase converting ATP into cyclic adenosine monophosphate (cAMP), whereas Gαi-coupled GPCRs block adenylyl cyclase and the formation of cAMP.

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PMC11680391

We then constructed a linear regression model to identify factors affecting the dependent variable BTSCC: BTSCC~Agreement construct + herd size The questions for the dairy farmer and herd veterinarian were transformed into the defined constructs, and the allocation of the questions to each construct was carried out bef...

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PMC11670407

This study highlights the importance of OTULIN in OS chemoresistance and provides a promising approach for targeting the OTULIN-GPX4 axis to improve the prognosis of OS patients.

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PMC11591038

For example, FGF21 lessened tau hyperphosphorylation and oxidative stress in cellular and rat models of AD; its beneficial effects involved the inhibition of the PP2A/MAPKs/HIF-1α pathway (Table 2).

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PMC9429973

In the expansion phase, up to 14 pts at the selected safe and pharmacologically active dose/s will be enrolled.

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PMC11126803

B, tumor average photons for ccRCC from xenograft mice described above.

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PMC11650848

Blood DNA methylation was used as a control comparison (grey bar).

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PMC9429973

Results: We found DAC combined with APR-246 had a synergistic effect on tumor cells with TP53 mutation in vitro.

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PMC9429973

The manufacturer’s protocol recommends a twice-weekly dosing schedule.

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PMC11718809

Most circRNAs act as miRNA sponges, inhibiting miRNAs’ regulatory effects on target genes and thereby influencing target gene expression levels .

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PMC8750422

Furthermore, GPR87 overexpression promotes cancer cell growth and metastasis by upregulating CD133-positive cancer stem-like cells in liver cancer .

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PMC9436459

In TNF-α-stimulated HeLa cells, kuwanon J 2,4,10"-trimethyl ether (82) and kuwanon R (86) strongly inhibited NF-κB activity with the IC50 values of 4.65 and 7.38 μM, respectively .

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PMC11747467

We further constructed a xenograft tumor model in mice using control and ERBB2 overexpression T24 cells.

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PMC9429973

Clinical and laboratory data regarding patients with HC under palliative care who have been hospitalized and treated with HDC (BD SAF-T-Intima®, Braun) was collected through the medical chart review.

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PMC11751675

The data supporting this article have been included in the main manuscript.

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PMC10174970

In pan-function analysis, the cell line showing the highest genetic correlation to patient tumors was Panc 03.27 for PAAD cell lines from primary lesion sites and Capan-1 for PAAD cell lines from metastatic lesion sites.

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PMC9429973

It is essential that patients referred for HSCT undergo a thorough dental assessment and are deemed “dentally-fit” prior to transplant.

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PMC10507284

E–N) The IC50 of AZD0530, nilotinib, erlotinib, lapatinib, AZD6244, PD‐0325901, nutlin‐3, paclitaxel, PD‐0332991, and PLX4720 between low (n = 131) and high (n = 132) TROAP expression subpopulations.

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PMC8839885

This assay utilizes an antibody that recognizes only the cleaved PARP protein from human origin.

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PMC11429241

On the other hand, the A2780 cell line showed substantial changes in gene expression when it was grown on spheroid scaffolds.

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PMC2118063

Expression of IRF4 in B cells is regulated primarily by pathways known to drive lymphocyte activation rather than by IFN, which is the case for most other IRF family members.

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PMC8469018

DHODH converts L-dihydroorotate (DHO) to orotate (ORO).

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PMC9917080

We have previously shown that the application of selenium nanoparticles, as well as the selenium and sorafenib nanocomplex, caused the generation of Ca responses in HepG2 hepatocellular carcinoma cells.

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PMC11721096

C. arabica possesses various health benefits that prevent cardiovascular disease, type 2 diabetes, Parkinson’s disease, and Alzheimer’s disease .

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PMC11611077

The average area and intensity in each clone are shown in Table 1.

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PMC11706491

High expression levels of fluorescent proteins may impose metabolic burdens on cells or perturb endogenous signaling pathways, leading to unintended effects on cell behavior.

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PMC11739484

Additionally, MMPs modulate immune responses within the tumor microenvironment, creating an immunosuppressive milieu that facilitates immune evasion and tumor progression.

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PMC11792888

MRC-5 has helped to determine safe concentration ranges for these drugs and their combination .

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PMC11641532

Moreover, we conducted both in vitro and in vivo validations to confirm the functional role of HSD3B7 in ccRCC progression.

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PMC11064533

COG functions/categories were considered significantly upregulated/downregulated if Benjamini-Hochberg corrected P value was equal to or lower than 0.05.

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PMC9429973

Approximately 880 patients are planned to be randomized at approximately 350 centers in North and South America, Europe, and Asia-Pacific.

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PMC5363531

All experiment was performed at least in duplicate for tree times, each firefly luciferase signal was normalized by renilla luciferase and the normalized values was relativized to pcDNA transfection.

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PMC8633974

LNP colocalization with the endosomal compartments suggest that the TatDE LNPs travel through the endosomal compartments.

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PMC10380508

The relationship between the expression level of PAX genes and patient survival in different RCC subtypes was analyzed by GEPIA.

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PMC11621493

MMAT assays revealed that the enzyme has no strict positional and FA preferences.

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PMC11635519

Representation of the interactions of the PepA’s N-terminal residue with the receptor binding site in the most representative cluster. (

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PMC10380508

For the MTT assay, cell transfections/manipulations were performed in duplicate in a 96-well plate format.

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PMC11806106

With this cell line, we conducted FRET measurements in a 96-well microtiter plate configuration using a plate reader.

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PMC11678368

and it decreases slightly to 4.22 kcal/mol after ZPE correction.

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PMC11721064

In contrast, ΔNP63α expression was very faint in the central corneal epithelium.

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PMC9429973

Methods: The primary endpoint of the trial is progression-free survival.

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PMC11597291

The red blood cells (RBC, erythrocytes) were washed thrice with normal saline and a ratio of 1:20 pure RBC was prepared at a final volume of 2 mL. The nCGO and nCGO-PEG particles were prepared in PBS for concentrations in the range of 0.5 μg/mL to 1000 μg/mL. Then, equal quantities of RBC and particles were mixed with ...

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PMC11610461

Metformin stimulates PSENEN to bind to the ATP6AP1 subunit and inhibits lysosomal proton pump v-ATPase activity, resulting in the activation of the AMPK pathway.

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PMC9429973

Among pts who successfully collected ≥2×10/Kg CD34 (n=287, 95%), 34 (12%) required PLX: 23 (68%) due to a CD34/uL count ≤20 after ≥4 days of G-CSF and 11 (32%) to a collection <1×10/Kg after the first apheresis day.

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PMC11786704

Then all mice were fed normally.

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PMC11794847

A: Flow cytometry histograms illustrating the increased rate of apoptosis in T cells after the silencing of HVEM, indicating its potential role in T cell survival; B: Western blot analysis confirming T cell apoptosis post-HVEM knockdown; C: Graphical representation of T cell activation markers measured by flow cytometr...

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PMC6889484

of Hypermutated Clones/Total Clones Sequenced (%)Average G-to-A Mutations/Hypermutated CloneDinucleotide Context of G-to-A MutationsTotal G-to-A MutationsTotal G-to-A Mutations/Total Clones SequencedGGGAGCGTA3G(DK)−52/52 (100%)40.31,85122747862,11640.7+40/60 (66.7%)18.56784461073812.3A33G(DK)−28/55 (50.9%)13.1319163834...

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PMC6024716

The previous report by Xiao et al. also showed that improved expression by addition of external polyamines is concentration-dependent up to an optimal concentration, above which higher concentrations have negative effects on the expression .

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PMC11782508

Cells treated with the IC₅₀ concentration of purified azurin. (

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PMC5839394

Protein spots were quantified, normalized and inter-gel matched and only differentially expressed proteins with the threshold settings with at least fold change ≥ 1.3 and p-value < 0.01, were considered regulated (Supplementary Table 1).

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PMC10589262

The upregulation of CHOP remained even after 24 h of TG and PF treatment (Supplementary Fig. S12).

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PMC9429973

The tipping values of Ret percentage, ALC and RDW-CV were 0.45%, 1.06×10/L and 11.75%, respectively.

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PMC7504302

Three of those MPM cell lines showed very high sensitivity to PD-173074, an FGFR1 and FGFR3 kinase inhibitor (FGFRi).

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PMC11228511

SMCs expressing GFP with a nuclear localization signal (nls-GFP) have been described previously (21).

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PMC10522430

The prevention of NF-κB activation has become a significant focus in the field of cancer treatment.

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PMC6835428

A drawback of KURAMOCHI, however, is linked to the difficulties of its grafting into xenograft mouse models.

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PMC11201989

The primary cilium is a microtubule-based structure that extends from the apical surface of most eukaryotic cells and functions as a sensory organelle, sensing and transducing environmental cues through ciliary sensory receptors, such as the polycystins .

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PMC11543853

Membrane penetration by non-enveloped viruses is diverse and generally not well understood.

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PMC11033180

The number of synapsin 1 clusters was normalized to β3-tubulin area.

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PMC11127909

This effect could maintain mitochondrial function, thereby favoring OS cell survival.

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PMC5673060

Biological function analysis of PazR versus A204 parental cells. (

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PMC11634027

Statistical tests for graphs showing wing area, roundness, and relative cross-vein distance were determined by one-way ANOVA.

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PMC3122064

In the present study, we have used a panel of cisplatin-sensitive and -resistant wild-type p53 expressing TC cell lines to compare cisplatin responses (Table 1) with the cellular localisation of p53 and MDM2, and MDM2-p53 complex formation (Figures 1a–c, Supplementary Figure 1).

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PMC11534035

The pathway by which GPER1 influences PAI1 expression has not yet been fully understood and warrants further investigation.

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PMC11344246

Changes in cell viability for each cell line.

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PMC5415764

The P-gp expression of A2780 or A2780/PTX cells after pretreatment with various formulations was detected by flow cytometry analysis (Fig. 4A).

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PMC8343815

At passage 3 of the cell culture process, 103 cells were counted by hemocytometer, seeded onto a 96-well plate, and incubated for 12 hours to adhere.

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