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PMC10772747
In our study, after conducting an analysis of the potential anticancer compounds through a network pharmacology approach, we proceeded to strengthen the results by conducting cytotoxicity tests on breast cancer cells in vitro.
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PMC9503541
Thus, the main objective of this study was to extract and partially purify the bioactive compounds present in A. muricata leaves through sequential solvent extraction and column chromatography.
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PMC11462929
Hence, we described this distinctive amplification in BCP‐ALL cell lines as “BENC‐CNA.”
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PMC10891340
Cells were collected to extract the mRNA, and the mRNA expression levels of mitochondrial pathway genes Bak, Bcl-xl, PARP, Cytc, Smac and AIF were detected by Q-RT-PCR.
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PMC11676169
As acetylation of KU70 is associated with induction of apoptosis and poor DNA repair, BCAT1 overexpression in T-ALL is cytoprotective, especially following exposure to DNA-damaging agents.
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PMC7887261
POMC encodes a polypeptide hormone precursor that regulating energy metabolism, nicotinic-induced weight loss, and immune reactions.
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PMC11740907
For fluorescence-triggered sorting of cells (FACS), a suitable FL2-A channel was used.
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PMC6379402
In our cancer-specific study, we use the procedure presented above to create tissue-specific networks for four cancer tissues (breast, prostate, lung, and colorectal cancers) and for the four corresponding control tissues (breast glandular cells, prostate glandular cells, lung pneumocytes, and colon glandular cells).
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PMC11726848
The underlying mechanisms here can be (i) p53-dependent senescence based on the activation of AMP-dependent protein kinase, which is associated with mitochondrial dysfunction; (ii) the activation of proteins of the RAS family, leading to glycolysis-biased metabolic switch and the additional activation of the hypoxia fa...
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PMC9429973
Therapy for prior non-MPN cancer were grouped as: therapy implicated in tMN per 2016 WHO criteria (alkylating agents, antimetabolites, topoisomerase inhibitors, antitubulin agents, and ionizing radiation), non-implicated therapies (targeted inhibitors, hormone therapy, other), and surgery/observation alone.
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PMC11093197
Then, cells were washed with PBS and stained with 0.5% crystal violet solution (#031‐04852, Wako) for 30 min.
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PMC11087055
In summary, our study illustrates the relationships between midline morphogenesis, the large-scale cell flow, and an axis-inducing factor in amniote gastrulation.
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PMC10523483
Since three of the four contact sites reside within H1.2 N-terminal domain (SI Appendix, Fig. S10A), we constructed a Flag-H1.2-ΔN plasmid expressing an N(1–35)-deleted H1.2.
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PMC3765139
In addition, IGF-1 and its major corresponding binding protein IGFBP-3 were, respectively, 3.5 and 2.7-fold upregulated in CD133+ D10 cells as compared to the CD133- fraction.
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PMC11766309
After a period of 2 weeks, the cells were treated with methanol to immobilize them and then subjected to staining with crystal violet.
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PMC11641630
The treated cells were collected by centrifugation at 250× g for 10 min, and the pellets were resuspended in DMEM-F12 medium.
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PMC11471176
This equation signifies an impeccable conformity to the observed data.
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PMC10958426
Scatter plot of the stemness score along pseudotime trajectories showed the stemness increase quickly at the early stage. (
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PMC11789597
CAV1 depletion also enhanced the sensitivity to starvation in MM1S cells and further increased the ROS in MM1S cells (Figure 4L,M).
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PMC9429973
The analysis of the other AZA-induced MAPs showed that they resulted preferentially from the activity of the constitutive proteasome (vs the immunoproteasome) and derived preferentially from proteins having less aromatic residues (and therefore more prone to misfolding).
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PMC11286266
These findings align with previous evidence that N-ATF6α suppresses IRE1 signalling (Walter et al., 2018), and highlights the importance of ATF6α/IRE1 crosstalk.
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PMC9960565
In this regard, four metallodendrimers showed enhanced selectivity compared with cisplatin, the monodentate G2.5(COOPt((NH3)2Cl)32, and the bidentateG0.5(COOPt(NH3)2)4, G1.5(COOPt(NH3)2)8, and G3.5(COOPt((NH3)2)32 metallodendrimers.
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PMC11258145
This is of particular importance in the case of curcumin, because its hydrophobic chemical nature causes its molecules to localize within cell membranes.
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PMC9118379
The detailed algorithm for checking the 11 isobaric substitutions is described in Choong et al. We also performed semitryptic cleavage examination to determine whether a variant peptide can be derived from semicleavage or terminal truncation of any wild-type peptide.
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PMC11687167
The objective response rate (ORR) and disease control rate (DCR) were significantly higher in the PCSK9 low-expression group than in the PCSK9 high-expression group (54.4% vs. 34.5% and 94.7% vs. 65.5%, respectively) .
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PMC11632064
Transfer on PVDF membranes was performed using Pierce Western blot transfer buffer (#35040; Thermo Fisher Scientific) and Trans-Blot SD semidry transfer cell (Bio-Rad) at 22 V and 0.2 A for 50 min.
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PMC7185206
Atezolizumab (Genentech) was conjugated with Alexafluor-647 per the manufacturer’s protocol (Invitrogen).
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PMC11655536
C Analysis of NHE1 expression levels in different stages of MM in TCGA datasets.
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PMC9429973
Median progression-free survival (PFS) after first treatment line for all pts in CD5 positive cohort was 25 months (95%CI 13.76-36.24), while median overall survival (OS) was not reached.
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PMC10114490
A Sequence of retrotranscribed SERPINA1 mRNA isolated from diHLC-T corresponding to the region of exon 6 containing the Glu366Lys mutation (PiZZ genotype).
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PMC11412752
Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) is a Gram-negative, facultative intracellular bacterial pathogen that can lead to severe gastroenteritis and systemic inflammation in humans and animals .
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PMC9780037
PEGylation with an excessive number of PEG molecules per cyt c molecule should also be avoided.
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PMC9429973
The nuclear factor erythroid 2–related factor 2, NRF2, is a transcription factor that regulates the expression of several antioxidants and detoxification systems and works as a protective mechanism in normal cells against malignant transformation.
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PMC11707577
After the incubation time, the polyps were washed several times with fresh Hydra solution and the images were acquired with an inverted microscope equipped with a Leica K5C digital microscope camera.
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PMC11634794
Surprisingly, we observed that the expression of LAMP1 remained largely unchanged during starvation.
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PMC5839394
Interestingly, tot-Ag was detected only in mitochondria and nuclei fractions, with a higher concentration in mitochondria with respect to nuclei (Figure 10), suggesting a prominent role of mitochondria in AgNPs-EPS-toxicity.
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PMC11024707
The ethics committee approval for this study was obtained from the Ethics Committee of Necmettin Erbakan University (approval number: 201518027).
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PMC9429973
Methods: We conducted a retrospective study on haematology patients who received rituximab from December 2019 to October 2021 and were diagnosed with COVID-19 pneumonia.
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PMC11792766
Differences were considered to be statistically significant when *p < 0.05; **p < 0.01; ***p < 0.001.
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PMC11419566
People are constantly trying to find innovative therapy to treat a variety of cancers.
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PMC11539788
Zhu et al. reported that RNF19A promoted the ubiquitination of BARD1, leading to the inhibition of homologous recombination (HR)-mediated DNA repair and thereby increasing the therapeutic efficiency of poly-(ADP‒ribose) polymerase inhibitors (PARPis) in breast cancer.
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PMC5330095
Chemical structure of cannabidiol The anti-HBV assay was performed as previously described with modifications to use in real time quantitative polymerase chain reaction (PCR) (TaqMan) to measure extracellular HBV DNA copy number associated with virions released from HepG2 2.2.15 cells.
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PMC11467800
Although there are many reports on the molecular mechanisms involved in cancer cell plasticity—especially under the context of epithelial‐mesenchymal transition (EMT), studies that report intercellular dynamics are relatively less predominant.
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PMC11596967
The DP1 complex has also been leveraged in developing radiation-inactivated whole-cell vaccines against several pathogens, such as poliovirus, methicillin-resistant Staphylococcus aureus, and multidrug-resistant Acinetobacter baumannii, due to its strong antioxidant properties, which stabilize and protect vaccine antig...
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PMC11675244
For instance, while Wnt-5a generally inhibits Wnt signaling, it also enhances invasiveness in melanoma cells .
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PMC11474209
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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PMC11644761
SK-N-BE replicative, differentiated by retinoic acid, and differentiated cells induced to neurodegeneration by using Fsk were treated with pterostilbene 10 μM and 100 μM for 4 and 24 h. Cell treatments were performed in culture medium with 1% fetal bovine serum (FBS).
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PMC8633974
J.H., M.H., B.K., and H.E.G hold a patent on a virus-like particle-based delivery for HIV-1 CRISPR therapeutics (Docket No. 19040PCT; Serial No. PCT/US2020/016126; International Publication No. WO 2020/160418 A1).
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PMC11438317
LP-DACS immunoprecipitation of these mutants revealed that Y237F had the lowest binding to LP-DACS, followed by Y261F, and Y75F (Fig. 3A, B).
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PMC9429973
287,34091–34100.
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PMC9429973
However, the role of bcor mutations in autophagy and MDS progression remains subject to debate.
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PMC9429973
We were able to point out the underlying Stat1-Irg1-itaconate signalling axis, connecting metabolic regulation and immune-phenotype of macrophages.
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PMC11705630
Cells were fixed with 4% PFA, permeabilized with 0.1% TritonX-100 for 10 min.
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PMC11746942
To elucidate the role of S1PR3 in psoriasis pathogenesis, we subjected S1PR3-KO mice to IMQ for 7 days.
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PMC6617630
p < 0.05 value was significant for both the concentrations in all the cell lines tested It has been shown in some cancer cell lines that suppression of MYC with BET inhibitors such as JQ1 reduced programmed cell death ligand 1 (PD-L1) and CD47 expression .
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PMC5833712
KB9520-activated ERβ had an additive effect on growth inhibition in combination with cisplatin and paclitaxel, respectively.
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PMC7504302
By inhibiting CDK4/6 activity, they cause hypophosphorylation and functional activation of pRb (the retinoblastoma tumor suppressor protein), thereby preventing cell cycle progression and proliferation .
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PMC11621565
Data are expressed as the mean ± SEM of four independent experiments carried out in duplicate (for curli CsgA 16 µg/ml and PSMα1 16 µg/ml – three independent experiments carried out in duplicate).
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PMC8735881
In order to confirm the role of the 10E8 part, the inhibitory activity of P41 in two representative constructs (CMI02 and CMI06) was abolished by mutating eight important amino acids in the peptide sequence (P41m in Figure 6(A)).
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PMC11661040
Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were utilized for bioinformatics analysis.
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PMC11718809
The quality and purity of total RNA were evaluated using a nanophotometer spectrophotometer (IMPLEN, Munich, Germany), and integrity was confirmed with a Bioanalyzer 2100 system (Agilent Technologies, Palo Alto, CA, USA) and the RNA Nano 6000 assay kit (Agilent Technologies, Santa Clara, CA, USA).
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PMC11172027
The effect of NALM in both cell lines does not exhibit any effect.
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PMC9429973
Follow-up for progression-free survival will be Q3W until progressive disease, start of new anticancer therapy, withdrawal of consent, end of study, or death.
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PMC11574271
The weight of the tumor is shown in (C).
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PMC11011837
The results are shown in Table 1.
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PMC8193046
The corresponding IC50 values can be found in Table 1.
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PMC11705067
These results highlight that they may serve as possible therapeutic targets against ccRCC.
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PMC9429973
Summary/Conclusion: myTcell is a smartphone app supporting the application of CAR T cells and BiTEs.
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PMC9429973
J. Suttorp, J. L. Lühmann, D. Steinemann, D. Reinhardt, N. von Neuhoff, M. Schneider Clinic of Pediatrics III, University Hospital Essen, Essen; Department of Human Genetics, Hannover Medical School, Hannover, Germany Background: AML is the 2nd most frequently diagnosed blood cancer in children affecting approximately ...
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PMC11590870
The pellet was recovered, dissolved in double-distilled water, and dialyzed with a membrane with a molecular weight cut-off (MWCO) of 2 kDa against double-distilled water at 4 °C.
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PMC10957991
Confocal imaging of fixed samples was conducted with Zeiss LSM 780, Zeiss Cell Observer.
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PMC3931643
Results represent the percentage of cells that are Annexin V positive only and are averaged for 3 different experiments.
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PMC11792888
Next, the synergistic effect of scorpion venom and etoposide on cell death was studied.
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PMC11194678
Time 0 refers to the time point of the photobleaching pulse.
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PMC11290772
This disease is a significant contributor to cancer-related mortality in women, ranking as the fifth leading cause of death.
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PMC11594641
Single cells were expanded and analyzed for the loss of the Rab27A or Rab27B protein by Western blot.
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PMC10495912
Statistical analysis Data are expressed as Mean ± SD from five independent experiments.
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PMC9587298
Anthocyanins present in elderberry extracts but substituted in A-ring with glucose, cyanidin-3,5-glucoside, and cyanidin-3-sambubioside-5-glucoside were not able to trap MGO under our experimental conditions.
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PMC10926885
Methylation has been discovered to control the expression of tumour suppressor or oncogene genes, impacting the development and spread of cancer.
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PMC11088135
The miR-376a-3p mimic significantly increased the expression of miR-376a-3p in U251 cells compared to the mimic control group (Fig. 6A).
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PMC11621493
It is expressed in keratinocytes, where it is strongly upregulated by proinflammatory cytokines.
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PMC10854447
The type, position, and number of halogen atoms had a significant effect on antiproliferative activity of 7a–o, with activity increasing in the order 2,4-di-Cl > 3-Br > 3-Cl > 4-Br > 4-Cl > 4-F. The dihalo derivative was also more active than the mono-halo derivative in 6a–o, but the 4-position is better tolerated than...
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PMC10729469
This novel idea provides a specific immune signature in ameliorating disease due to Treg’s vibrant anti-inflammatory and immunosuppressive activities [28–35].
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PMC6948907
When cells became >80% confluent, 5 × 10 cells (HepG2) were seeded into 96-well plates (Becton-Dickinson) for 24 h in DMEM culture medium before incubation with certain concentrations of GE (0, 10, 25, 50 and 100 μM/lit), which was dissolved in DMSO; DMSO was present at 0.01–0.3% in the medium.
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PMC11519583
Sections of the TA muscles, from either control or Ror2 cKO mice 2 weeks after injection with Ctx (e) or glycerol (f), were stained with anti-laminin antibody (magenta) and DAPI (cyan).
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PMC11047729
Compared to the control group, it decreased the most: 5,16-fold at 24 h .
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PMC11705901
However, rs4686302 is in complete LD with several SNPs such as rs53576, rs237902, rs237900, rs237899, and rs34880121; rs2254298 is in complete LD with rs2254295, rs237889, rs1131148 and other OXTR SNPs, and rs237887 is in complete LD with rs918316, rs4686301, and rs2268491.
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PMC11628904
Scale bars = 50 μm unless otherwise indicated.
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PMC11682525
P&0.01 and ****P&0.001; ns: non-significant.
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PMC11790599
Non-microscopy-based quantitative method for the analysis of macropinocytosis utilizes Flow Activated Cell Sorting (FACS).
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PMC10419319
The disease–gene targets and drug-prediction gene targets were combined through Venny 2.1 software (https://bioinfogp.cnb.csic.es/tools/venny/index.html, accessed on 25 May 2023) to obtain common gene targets.
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PMC9960565
in the dark under a nitrogen atmosphere (Scheme 7).
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PMC11314247
Wawruszak et al. obtained similar results in 2015 when they tested combinations of VPA and cisplatin in other cell lines, including MDA-MB-231 .
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PMC11252033
FTSite uses the hot spots detected by FTMap to identify and rank binding sites, on the basis that the binding site of a protein generally consists of a strong main hot spot plus some other adjacent hot spots (Ngan et al., 2012).
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PMC5311252
The peptides generated from each sample were subsequently individually labeled with tandem mass tag (TMT)-10plex isobaric label reagents (Thermo Fisher Scientific, Cat.
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PMC9587298
On the other hand, quercetin was not able to react with MGO under the same conditions.
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PMC9429973
During the first 3 quarters of 2021/22, new diagnoses had returned to pre-pandemic levels.
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PMC11596967
Treatment with 10 µM Ddes-P3 significantly reduced the presence of JC-1 monomers and decreased the percentage of MMP loss (Figure 4B,C).
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PMC9429973
Clinical and laboratory parameters as well as antibody titers against S1 domain of SARS-CoV-2 were determined in the recipients on days 1–7 and on days 14, 21 and 28.
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PMC11587606
We further found that MCF10A/RH cells in the 3D acinus formation model showed an about 1.5 times increase of p-PKCζ and an about 2 times increase of total PKCζ protein (Fig. 2F), and the PKCζ mRNA levels increased about 1.5 times (Fig. 2G), compared to that in MCF10A/GFP control cells.
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