Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC8303372
This effect persisted throughout the analysis period.
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PMC11697189
The differences of tumor infiltrating immune cells between the two groups were compared by CIBERPORT. (
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PMC11739504
Western blots showing Kat2b and acetylated α-tubulin expression at 0, 6, 12, and 24 h after serum withdrawal.
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PMC11711127
Naturally this relies on the intimate contact achieved through organisation of an IS allowing for the targeted release of membrane lysing proteins such as perforin (159).
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PMC11706491
These analogs, which compete with ATP for the kinase ATP-binding pocket but cannot be processed, enable fine-tuned control of CDK activity .
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PMC11519077
Accordingly, in the present study, the expression level of MCP-1 in the IL-1β-induced Caco-2 cell group was significantly elevated compared to the control group.
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PMC9275501
In vitro experiments showed that (DOX + CUR)-micelles could reduce the DOX efflux rate through the inhibitory effect of CUR on P-gp, significantly increase the uptake of DOX by MCF-7/ADR cells, thereby enhancing the in vitro cytotoxicity of DOX.
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PMC11706776
Functionally, KCNN1 silencing leads to plasma membrane depolarization in a 2D or 3D cell model (Fig. 5A,B).
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PMC11680391
Herd veterinarians who did not return a completed questionnaire within two weeks of the farm visit received a reminder with an invitation to participate.
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PMC11727907
, GAPDH (14C10, cat.
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PMC11806106
The MOR-FRET-Sensors were constructed by using the NEBuilder Hifi DNA assembly kit (New England Biolabs) based on the rat MOR-wt, the sYFP2 from MORsYFP, and the pcDNA3.1+ vector, including a C-terminal mTur2 from EP4-mTur2.
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PMC10522430
The results of GACP exposure over 24, 48, and 72 hours exhibited varying percentages of cell viability.
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PMC7215722
Labeled cells were solubilized for 1 h at 4 °C in lysis buffer (25 mM Tris-HCl, pH 8, 50 mM NaCl, 0.5% Triton X-100, 0.5% sodium deoxycholate) and a mixture of AEBSF, aprotinin, bestatin, E-64, leupeptin and pepstatin A (Sigma Munich, Germany), as described previously .
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PMC9429973
Image: Summary/Conclusion: Our study supports the fact that BL-IPI predicts survival efficiently, however taking our aforementioned results into consideration, we propose that instead of “CNS involvement”, “CNS involvement and bone marrow involvement” or “stage 4 disease” could be added to the score as a risk factor.
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PMC11522251
B–D After silencing HOXB8 in CACO2 and HCT116 cells for 24 h, HOXB8, GAPDH, STAT3, and p-STAT3 protein expression was determined by western blot. *
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PMC11718109
COS7 cells were triple-transfected with untagged synapsin (cyan) and VMAT2-GFP (green) or mCherry-synapsin (magenta) and VMAT2-Flag (cyan) with one of the following proteins as indicated: VAMP2-mCherry (magenta) (A), mCherry-Rab3A (magenta) (B), synaptotagmin 1-mCherry (magenta) (C), mCherry-SCAMP5 (magenta) (D), and S...
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PMC7812570
To measure the inhibitory activity of GPI-m36.4 or GPI-FluIgG03 in transduced TZM-bl cells, a virus at 200 TCID50 was added to cells (1 × 10/well) and incubated for 2 days at 37 °C in 5% CO2.
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PMC9878278
SC and A549 cells cultured in 6-, 24-or 96-well plates were infected with ZIKV MOI of 1 for 1 h at 37°C as described previously (Siemann et al., 2017; Strange et al., 2021).
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PMC9429973
Image: Summary/Conclusion: A system has been developed for multiplex PCR diagnostics of SARS-CoV-2, which makes it possible to eliminate errors leading to false-negative and false-positive results at all stages of analysis.
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PMC9429973
Among the 71 serious AR reported, only 2 were considered as potentially related to iada, corresponding to a differentiation syndrome and a fatal intracranial hemorrhage, previously presented at EHA 2021.
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PMC10988808
G Representative images and bar graphs of wound healing assays of Caki-1 and 786–0 cells after overexpression CCDC25 (**p < 0.01) CCDC25 reduced the proliferation and migration of ccRCC in vitro.
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PMC11085211
Hence, it could be hypothesized that the presence of the pyrogallol moiety is essential for the anticancer activity in GIST, a hypothesis supported once again by the analysis of the active cluster C.2A-60-61.
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PMC11635087
Color online) Ultrastructural analyses of isolated and incorporated chloroplasts in mammalian cells. (
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PMC11509224
Agelamasine A (44, Figure 6) is the first diterpene alkaloid with a rearranged (4→2)-abeo-clerodane skeleton from a marine source, while agelamasine B (45, Figure 6) is a clerodane diterpene alkaloid.
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PMC6461034
IC50 values for the cell lines were obtained from the GDSC website (Iorio et al, 2016) (version 17.3).
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PMC9596868
Points below the isoeffect line indicate synergism and those above the line indicate antagonism. (
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PMC9261184
The experimental design aimed to ensure that there were no unaccounted emission sources by identifying all potential leaks and with regular surveying, but a general disadvantage of bottom-up measurements is that we are unable to confirm the absence of “unknown unknowns”, that is, potential emission sources that were no...
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PMC11218145
The production of mitochondrial reactive oxygen species was analyzed by using the mitochondrial superoxide indicator MitoSox.
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PMC11635087
This suggests that the schyzon chloroplast may remain viable in animal cells for long periods.
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PMC8875242
Similarly, a docking analysis using a mice model of ABCB1a (PDB code: 4M1M, Figure S1) showed large binding contact in an ABCB1a cavity (Figure S2) and binding free energy (Table S3).
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PMC9429973
Pathogenic and likely pathogenic variants were identified in 59 patients (31.2%), including 47 with leukemia predisposing syndromes.
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PMC11727638
They were analyzed using an automated cell counter (Countess II FL; Thermo Fisher Scientific, Waltham, MA, USA).
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PMC10810426
All viruses, including the PM15 mutant, were subjected to reverse transcriptase quantitative PCR (RT-qPCR) with primers located in the env gene and the number of viruses was estimated from the amount of virus-specific RNA, using standard curve analysis (Table 1).
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PMC11568601
Protein concentrations in all samples were adjusted to 1 µg/mL with a loading dose of 15 µg.
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PMC11791203
ADME characteristics of phytochemicals identified by GC-MS from the chloroform extract of H. malabarica.
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PMC11401350
However, both ICOS and PD-1 cannot be chosen for CAR T cell generation in vivo since they are expressed on both CD4 and CD8 T cells which will lead to fratricide, which is the phenomenon we avoid here by targeting CD8 T cells, exclusively.
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PMC11697703
CD1 wild-type time pregnant females were obtained from Charles River.
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PMC9429973
Aims: To identify the adaptive response to arg and trp deprivation at metabolic and transcriptional level in HL.
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PMC9250505
p < 0.05, **p < 0.01, ***p < 0.001.
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PMC11802855
A total volume of 100 µL of the cell suspension was injected in the direction of blood flow.
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PMC8567602
To scale up the quantitative use of this algorithm, we performed gradients in triplicate for each of five human synovial sarcoma cell lines and three control cell lines.
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PMC4277423
TZM.bl cells were obtained from the NIH AIDS Research and Reference Reagent Program (ARRRP, Germantown, MD) and maintained in complete DMEM.
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PMC11515150
Expansion of NK cells with IL-2 combined with IL-15 or without IL-15 for 14 days (n = 3, left panel), and cell viability of NK cells with different concentrations of IL-15 (n = 3, right panel). (
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PMC9429973
Ageing experiments will be continued until an age of 15-18 months to investigate an oncogenic potential of mutant STAT5B in NK cells at a later timepoint.
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PMC11126803
To study the effect of LncRNA-SERB on tumor cells cytology, we tested its expression levels in different ccRCC cells relative to normal proximal tubule epithelial cells.
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PMC7215832
As a reference gene we used ß-actin with the following primer sets: β-actin: Forward: TCACCCACACTGTGCCCATCTACGA β-actin: Reverse: CAGCGGAACCGCTCATTGCCAATGG β-actin: Primer: ATG CCCTCCCCCATGCCATCCTGCGT The PCR reactions for PCFT were performed using the Hs00560565_m1 Assay-on-Demand product (Applied Biosystems, Foster C...
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PMC9046263
The H4 cell line similarly demonstrated significant underexpression of the ERV316A3 (ERV1), HERVE, and HERVL (corrected p = 0.039, 0.025, 0.0019).
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PMC8584666
As a result, the GPI-80 level could be detected using both PE-conjugated anti-GPI-80 antibody (3H9) and FITC-conjugated anti-FLAG antibody.
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PMC10898159
FOXF1 loss results in decreased ETV1 protein, and global loss of ETV1 chromatin binding.
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PMC9250505
Statistical significance was analyzed based on endpoint xenograft volume.
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PMC11742290
Multicolor lineage tracing experiments have shown that LGR5 + stem cells divide symmetrically .
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PMC10606998
The average difference between ROS production by the cells cultured without/with SPIONs after X-ray irradiation is 10%, which indicates a slight increase in the level of ROS due to the combined effect of nanoparticles and irradiation.
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PMC9429973
The 6- and 12-month median (95% CI) OS rates were 63% (42–78) and 49% (28–67), respectively.
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PMC11321678
For example, cancer cells exploit the signaling pathway initiated by neurotransmitters to enhance their growth and spread.
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PMC11078693
Stepwise demonstration of removal of a 25 mm cover glass from a flat bottom 50 mL tube (A) 25 mm cover glass stained purple for visualization purposes at the bottom of a tube. (
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PMC7553912
During the incubation, the sections were exposed to light from a 60-W incandescent lamp at a distance of 15 cm.
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PMC11248911
for C16H13Cl3N2 (339.65): C, 56.58; H, 3.86; N, 8.25.
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PMC9599726
provide only limited benefits .
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PMC11026382
Prior work by ourselves and others indicates that these two enzymes are strongly functionally coupled to each other and less coupled to the remainder of the pathway: they co-evolve with each other in terms of synteny and gene co-occurrence across bacterial species (while far less so with the remainder of the pathway), ...
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PMC11726848
The resulting dose–response ratios were used to calculate the LD50 (the radiation dose permitting 50% living cells) and D37 (the radiation dose permitting 37% living cells) using a four-parameter lognormal distribution model.
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PMC11519583
control: 960 myofibers from three animals (e) and 1061 myofibers from four animals (f), Ror2 cKO: 2779 myofibers from five animals (e) and 1344 myofibers from four animals (f)).
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PMC11521786
Our findings are consistent with and support previous reports, which propose that PAbs induced by cancer vaccines targeting oncogenic receptors promote antigen degradation and interfere with tumor cell growth in vitro and/or tumor progression in vivo.
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PMC9812014
was used in an in vitro study on both the HSV-I and II viral strains in Vero cells.
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PMC11429241
However, a cubic-pore scaffold design is only suitable for finding the right pore size for cell growth rather than mimicking the ECM.
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PMC11568601
was used to lyse 143B cells on ice for 30 min (100 µL per well, 6-well plates).
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PMC11802855
Protein expression, both intracellular and secreted, was assessed using Western blotting (Fig. 4F–I) and ELISA (Fig. 4J–M).Fig.
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PMC11506670
These rely on the evolutionary conservation of the amino acid sequence, the biochemical properties of each residue, and a recorded deleterious effect on known diseases .
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PMC5311252
The mRNAs and proteins quantified in response to miR-372-3p mimics were then stratified into four groups according to the number of algorithms predicting them as targets of miR-372-3p (no predictions, 1–2 predictions, 3–4 predictions and more than 4 predictions).
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PMC11474209
Envision a world where portable optical biosensors could quickly and precisely determine whether local bodies of water have microcystin for environmental scientists and water treatment plant operators.
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PMC6468656
GAPDH was used as endogenous control.
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PMC11787355
To validate target-dependent killing even at relatively low PTPRZ1 expression levels, we generated oligoclonal PTPRZ1 KO lines from D170_44 with two different guide RNAs (Fig. 5i).
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PMC11705862
In addition, in experimental studies, we demonstrated decreased expression of IRIS-1 and 2 in response to hyperglycemia, and a rescuing effect of the two CD59 splice variants on insulin secretion in CD59, IRIS-1 and 2 knockout cells, suggesting a critical role of IRIS-1 and 2 variants in SNARE-dependent release of vesi...
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PMC11437637
Changes in cytokine levels in the tumor microenvironment lead to a Th1-to-Th2 shift, resulting in Th1/Th2 imbalance, which is one of the determinants of tumor development , but reduced tumor burden reduction helps improve this imbalance.
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PMC11472639
James Murray: Supervision, Project administration, Methodology, Investigation.
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PMC11591038
Currently no effective treatment for the deteriorating clinical course of dementia is available, thus contributing substantial economic burdens to the patients’ families and eventually to the whole society .
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PMC11543853
Frames were aligned to compensate for drift and beam-induced motion during image acquisition using the program MotionCor2.
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PMC11457557
eNOS is a protein that catalyzes the synthesis of nitric oxide (NO) from L-arginine and has been linked to the development of DVC.
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PMC10849234
As primary granules are the last granules to be released during a degranulation event and require the strongest stimulus to induce , we decided that primary granule exocytosis was a suitable marker for full degranulation.
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PMC11768927
Olagnier et al. revealed that treatment of VSV-resistant cancer cells with the antioxidant compound sulforaphane stabilized the Nrf2 transcription factor and promoted its nuclear translocation.
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PMC9250505
Previous studies have demonstrated that the proapoptotic BCL-2 family members, Bax and Bid, can promote cell death by inhibiting HR DNA repair independent of apoptosis.
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PMC11012012
They revealed that SLAMF2/CD48 was significantly upregulated in low-risk DLBCL patients whereas IL1RL, PSDM3, and RXFP3 were strongly elevated in high-risk DLBCL patients .
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PMC9872547
Quantitative measurement of E6, E7, P53, and Rb gene expression was performed using the comparative quantification method by real-time RT-PCR in ABI Step One Sequence Detection System (Applied Bio-systems, CA, USA).
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PMC11543885
Import to STRING Database: Import the filtered data into the STRING database search portal.c.
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PMC11656657
For the 143B model of sarcoma (Fig. 3H), CAR.GD2 T-cells exhibited an efficient tumor control after every round of tumor exposure (residual tumor cells at day + 20 was 38.5% ± 14.2% for CAR.GD2 T-cells and 89.9% ± 4.0% for NT T-cells, p = 0.014) (Fig. 3I).
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PMC11680578
We have analyzed the effect of the combinatorial treatment of PTX and RGZ on the distribution of SKOV-3 cells in the different phases of cell cycle.
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PMC2614416
Emili and co-workers performed a comparative proteomics of protein expression patterns in proliferating MCF-7 breast cancer cells and normal human mammary epithelial cells using gel-free shotgun proteomics.
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PMC5034105
The intestinal (Caco-2) cell line was also highly susceptible to ZIKV, which corroborated with the high viral load detected in the intestines of ZIKV-infected mice.
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PMC11568601
Fig. 6Knocking down of IRE1 or inhibiting of ER stress suppresses the 143B cell apoptosis.
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PMC11172027
It remained almost the same as the respective baseline controls.
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PMC11476666
For SOX2, treatment with 30 µM DHS or RSV resulted in a statistically significant reduced expression (p < 0.01) compared to the untreated and DMSO controls (Figure 3b).
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PMC11696576
AVX002 and AVX235 were synthesized by Synthetica AS, Oslo.
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PMC9351137
DAPI (blue), anti-α-tubulin (green), tested CRS (red), and merge.
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PMC11748618
Significance was determined against p ≤ 0.05.
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PMC9275501
Natural drugs are safe and have little side effects (Liu et al., 2020b), which can enhance immunity and improve chemotherapy sensitivity.
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PMC11301242
Of the identified ecDNA genes, 225 were protein-coding, 32 were lncRNAs, with the remainder belonging to other gene types.
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PMC9429973
Among the CML patients, 22 patients (68.75%) were in chronic phase, 3 (9.3%) in accelerated phase and 7 (22.8%) in blast phase with all of them being myeloid blast crisis.
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PMC9429973
In the last years the identification of cytogenetic and molecular biomarkers has improved the AML classification considering prognosis, and allowing a better risk-adapted treatment strategy.
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PMC11721064
Quantitative analysis (D) of p63α + cells percentages revealed that the LN-KS group showed more remarkable p63α + cells populations than the LN-SH group, which indicated KSFM is more sufficient in maintaining the stemness of KPCs(scale bar = 50 μm).
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PMC11705067
The KEGG results revealed that these genes were mainly involved in the process of endocytosis, base excision repair and ether lipid metabolism (Fig. 4J).
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PMC11538390
LD pruning was performed with PLINK (v2.00a2.3LM) with a window size of 1 mb and r = 0.1.
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