OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11678448	The GO enrichment analysis of upregulated DEGs revealed that the biological processes that were significantly enriched primarily included cytokine-mediated signaling pathways and cellular responses to cytokine stimuli (Figure S1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11462929	The top panel indicates amplification regions detected in 38 BCP‐ALL cell lines by the array copy number variation analyses using microarray dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top",...
PMC11697065	To better dissect correlation data according to molecule format (monoclonal and bispecific antibodies) separate analysis was performed (Supplemental Figure 6A-H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Flow cytometry analysis was performed to detect T cell subsets of active ITP mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "analysis", "was", "performed", "to", "detect", ...
PMC11750165	Cell lines were cultured at 37°C in a 5% CO2 incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "were", "cultured", "at", "37", "°", "C", ...
PMC8751435	Effect of CME on lactate dehydrogenase release in A549 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Effect", "of", "CME", "on", "lactate", "dehydrogenase", "release", "in", "A549", "cells...
PMC6600592	Oximes (4A-1, 4B-1, 4C-1 and 4D-1) which R=H showed weaker anti-HBsAg and anti-HBeAg activities, weaker affinities to the selected target protein in docking than those compounds which R=Me and benzyl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9111184	These modifications can be attributed to structural changes in DNA volume or density.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "modifications", "can", "be", "attributed", "to", "structural", "ch...
PMC10079526	LFQ intensities were Log2 transformed, right-sided Student’s t-test was (FDR 0.05 q-value) performed between His10-SUMO2 enriched samples and their parental control counterparts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9917080	Only when cells were treated with 5 μg/mL SeSo, up to 10% of astrocytes were recorded at the early stage of apoptosis (Figure 4C,F; Supplementary Figure S9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: CC-95251 + ritux demonstrated a manageable safety profile and promising efficacy in pts with heavily pretreated CD20+ R/R NHL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion...
PMC10588957	The cell lysate was centrifuged at 12,000 × g at 4°C for 30 min to pellet the debris, and the protein concentration of the supernatant was estimated using a BCA Kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	n = 7–11). (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "7–11", ")", ".", "(" ] } ]
PMC11754432	There are six functional human LOX enzymes, named for the corresponding carbon of arachidonic acid (AA) in which molecular oxygen is inserted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11593713	The activity of GR in the assessed samples was expressed as μmoles of NADPH utilized in 1 min per 1 mg of protein (IU/min/mg protein).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	This study conducted an integrative analysis to identify miRNAs that may link PCOS with UCEC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "conducted", "an", "integrative", "analysis", ...
PMC11429241	Other studies have shown very minimal scaffold coverage with cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "studies", "have", "shown", "very", "minimal", "scaffold", "coverage", "with", "cells", ...
PMC11740907	The material when heated above temperature of glass transition had released the stress that have been generated in the material.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "material", "when", ...
PMC10958426	Pairs are ranked by the interaction difference between normal tissue and tumor tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pairs", "are", "ranked", "by", "the", "interaction", "difference", "between...
PMC9503669	Through these mechanisms, Nef allows HIV-infected cells to avoid immune surveillance by the host, prevents viral superinfection, and enhances viral infectivity and spread.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11343332	In this study, we examined pycnogenol's cytotoxic and pro-apoptotic effects on the breast cancer cell line MCF-7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O" ], "tokens": [ "In", ...
PMC9429973	For severe CRS prediction, 4 patients were divided into two groups based on tumor burden.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "severe", "CRS", "prediction", ",", "4", "...
PMC7759933	Similarly, the expression of CYP1A2 remained constant from day 5 onwards.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "the", "expression", "of", "CYP1A2", "remained", "constant", "f...
PMC11477621	To a solution of 2-acetyl pyrrole (109 mg, 1.00 mmol) in dry DMF (10 mL) was added NaH (44 mg, 60%, dispersion in paraffin liquid, 1.10 mmol) at 0 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11322866	After overexpression of RRM2, we observed a relatively slight decrease in EZH2 protein level but a significant decrease in H3K27me3 level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "ove...
PMC11078693	Work in a dimmed light environment for the remaining steps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Work", "in", "a", "dimmed", "light", "environment", "for", "the", "remaining", "steps", "....
PMC8009078	On the other hand, the binding energy of all molecules was explored after docking through ADV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "the", ...
PMC8735881	Error bars indicate the means ± standard deviations (SD). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "indicate", "the", "means", "±", "standard", "deviations", "(", ...
PMC11604015	Two patients relapsed with CD7-negative malignant cells, which can be explained by preexisting CD7-low or CD7-negative blasts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "patients", "relapsed", "with", ...
PMC11607321	The result contains SHAP values in a multidimensional array with shapes of , where each represents the number of latent dimensions, samples and features, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6468656	Canonical pathway analysis was performed to identify Diseases and Disorders (Figure 1B) and Molecular and Cellular Function (Figure 1C) according to the matched differentially expressed genes in IPA database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8427838	1Identification of moesin as a TMIGD1 binding protein: A Schematic of GST-TMIGD1 cytoplasmic domain and its expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1Identification", "of", "moesin", "as", ...
PMC9429973	R. M. Rifkin, C. L. Costello, R. E. Birhiray, S. Kambhampati, J. Richter, R. Abonour, H. C. Lee, Y. J. Kim, K. Ren, D. M. Stull, D. Cherepanov, K. Bogard, S. J. Noga, S. Girnius Rocky Mountain Cancer Centers/US Oncology Research, Denver; Moores Cancer Center, University of California San Diego, La Jolla; Hematology Onc...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461833	STXBP5 shRNA sh1, STXBP5 sh2, STXBP6 sh1, and STXBP6 sh2 were individually cloned and inserted into the pSuper-puro plasmid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "STXBP5", "sh...
PMC9250505	4NPB synergizes with PARP inhibitors to decrease cell survival in patient-derived EOC organoids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4NPB", "synergizes", "with", "PARP", "inhibitors", "to", "decrease", "cell"...
PMC9429973	Overall, 48 pts (16%) were poor mobilizers: 14 (5%) failed to yield ≥2×10/Kg CD34, while 34 (11%) required rescue with PLX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476222	This highlights the complexity of gangliosides due to variation in the fatty acid chain length.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "highlights", "the", "complexity", "of", "gangliosides", ...
PMC11628904	However, it is clear that a goal of such treatment should be to limit the spread of damage associated with burn wounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC11730320	However, subsequent successful rearrangement of a TCRβ chain, followed by signaling in association with pTCRα, inhibits further γδ rearrangements and silences their expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3995603	Furthermore, treatment with AC reduced the plasma levels of histamine and IgE in D. farinae-sensitized Nc/Nga mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "treatment", "with", ...
PMC9429973	Examining the dynamic changes of the TCR repertoire between diagnosis and week 5 for each patient, we found that patients with allergy had a much less similar clonotypic set between timepoints compared to non-allergic patients (P=0.003, Figure 1E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	H–J) Representative images of H&E staining, immunofluorescence staining of TUNEL and immunohistochemical staining of Ki-67 in tumors. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "–", ...
PMC9221284	It is, therefore, very likely that the translation of Trans1 leads to the formation of c-Myc2 from the AUG initiation codon that is located at exon 2 (Figure 3 and Figure S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: TC consisted of 185 pts, of which 103 (55.7%) were male, and the median age at diagnosis was 47 years (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8708099	To select the appropriate time of incubation with histamine, osthole, and FXF in the experiments, cell viability was assessed using a methyl thiazolyl tetrazolium (MTT) assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	We note that the fixation-induced changes to LLPS appearance can affect the physical characterization of in vivo LLPS systems based on fixed-cell imaging, such as the Gibbs energy of transfer between dilute and concentrated phases (Riback et al., 2020) and how far from the critical concentration a system is (Bracha et ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	To ensure that exendin 20–29 does not interact with GLP-1R, we utilized an acute IPGTT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "ensure", "that", "exendin", "20–29", "does", ...
PMC11528603	The differences between mean values were analyzed by unpaired Student’s t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "differences", "between", "mean", "values", "were", "analyzed", "by", "unp...
PMC11281366	To evaluate the impact of these miRNAs on the levels of CD59 mRNA and surface protein expression levels, we nucleofected either miRNAs-21, -26a or -29a mimics into primary CD4 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	Tumor sizes were measured every other day and recorded for 24 d. NS versus mMSCs-p14, P = 0.023; mMSCs-GFP versus mMSCs-p14, P = 0.047 by one-way ANOVA with Dunnett’s multiple comparisons test (n = 6 animals). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678368	The most stable models of these complexes are shown in Figure 1a and d, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "stable", "models", "of", "these", ...
PMC9429973	R. Thijssen, L. Tian, C. Flensburg, M. A. Anderson, A. Jarratt, H. Peng, I. Majewski, C. Tam, J. Seymour, P. Blombery, M. Ritchie, D. Huang, A. Roberts The Walter and Eliza Hall Institute of Medical Research; Medical Biology, University of Melbourne; Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Ca...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	All patients presented MMR at last follow-up and 92.3% deep MMR (≥MR4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "presented", "MMR", "at", "last", "follow...
PMC11286266	To identify regulators of ATF6α a library of pooled lentiviral single-guide RNAs (sgRNAs) targeting 20,680 predicted protein-coding genes in CHO cells, with ~6 sgRNAs per gene, was used (Ordóñez et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803149	This study demonstrated that aging significantly impairs anti-tumor responses of antigen-specific CD8 T cells in ACT using a mouse model of melanoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "stud...
PMC11514418	It has been confirmed in many in vitro and in vivo studies that APS can enhance immune activity, improve the local hematopoietic environment in the bone marrow, and accelerate stem cell proliferation, thereby inhibiting the occurrence and progression of tumors[19-21].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591038	Besides neurodegeneration, glial activation is one of the early alterations during AD progression, possibly related to the deposition of Aβ resulting in gliosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10203589	Fgfr1-4 has a similar structure with three basic domains: extracellular, membrane and intracellular.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fgfr1", "-", "4", "has", "a", "similar", ...
PMC9672323	The effect of dexamethasone and piroxicam was measured on the IFN-γ levels of T cells in PBMCs alone (a, c), and in co-culture with U-87 (b) (n = 5), and A-172 (d) (n = 4) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	A-F) Wing discs from homozygous ds (A-C) or ds (D-F) stained for Ds:V5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A-F", ")", "Wing", "di...
PMC3931643	1×10 cells were harvested, fixed in 50% ethanol, washed and stained in 0.1 mg/ml propidium iodide (PI)-staining solution (Life Technologies, Grand Island, NY).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540611	We have previously combined two types of systems by modifying gold nanoparticles with cationic carbosilane dendrons .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "previously", "combined", "two", "types",...
PMC7338939	The temporary reduction of tumor growth was observed in both IT and IT + IV groups during 13 days of treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "temporary", ...
PMC9581083	TCM has accumulated much experience in dealing with this sort of disease over the centuries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TCM", "has", "accumulated", "much", "experience", "in", "de...
PMC8777939	Cancer metastasis is the central cause of cancer therapy failure and mortality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "metastasis", "is", "the", "central", "cause", "of", "cancer", "therapy...
PMC11765988	In cases of DISR, the diagnosis is confirmed by the resolution of lesions after discontinuing the treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "cases", "of", "DISR", ",", ...
PMC11736898	No statistically significant differences were observed among any of the normal keratinocyte groups, although the difference between untreated and ketoconazole-treated normal keratinocytes approached statistical significance (p = 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8592717	PAL was reported to inhibit the production of ROS in rat PC12 cells and human SH-SY5Y cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "PAL", "was", "reported", "to", ...
PMC11655536	MM cell were seeded at a density of 5 × 10 /ml in 96-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MM", "cell", "were", "seeded", "at", "a", "density", ...
PMC11574271	Surprisingly, the levels of the HIF-2α protein were strongly correlated with the amount of RON in bladder cancer cells (Fig. 4C, D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Patients with CLL and DLBCL diagnosis within a time interval of 3 months were defined as concurrent RS-DLBCL (concurrent RS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "...
PMC7338939	Moreover, the Gompertz-based mathematical model determined a new drug resistance term in the present study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "Gompertz-based", "mathematical", ...
PMC11672881	Our study highlights the significant role of mitochondrial ROS generation and apoptotic signaling in mediating the anti-tumor effects of the combination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "study", "h...
PMC8524093	Therefore, understanding the potentials and limitations of the state-of-the-art experimental models is imperative to advance in the field.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "understanding", ...
PMC11470999	The cells were pre‐treated with CQ for 2 h, then PF was added for a further 24 h. (I) B16 and A375 cell stably expressing Flag‐CIP2A were transfected with an HA‐tagged ubiquitin expression plasmid (HA‐Ub).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "...
PMC9812014	Berberine can suppress IAV type A/PR/8/34 in the RAW-264.7 cells at over 1 μM, while the IC50 for berberine was 0.01 μM. This alkaloid also suppressed the growth of a separate strain of H1N1 IAV in vitro, with an IC50 of 0.44 μM. Berberine’s mode of action implies that it affects virus protein maturation as well as its...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791478	Short tandem repeat profiling was conducted, whereas for interspecies contamination cytochrome oxidase 1 barcoding was used (ATCC) for intraspecies contamination of human and mouse cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Furthermore, a closer examination of the media compositions used for generating and culturing tumor-derived organoids reveals that nearly all, if not all, contain cytokines and factors that promote neuronal growth in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	These effects might rely on inhibition of lipogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "effects", "might", "rely", "on", "inhibition", "of", "lipogenesis", "." ] } ]
PMC10890307	Instead, only a small amount of glutamine consumption was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Instead", ",", "only", "a", "small", "amount", "of", "glutamine", "consumption", "was...
PMC6803987	After 21 days of treatment with esculetin and 3TC, DHBV DNA levels of each group were lower when compared to the model group (* p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10808409	Cell cycle analysis revealed that Caco-2 cells treatment with IC50 of TPGS mixed micelles formula (O2) (17.1 µg/ml) resulted in cell cycle arrest at the S phase, whereas treatment with IC50 of FA (191 µg/ml) resulted in cell cycle arrest at G2/M phase and raised apoptosis (Table 4 and Fig. 5).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11775197	This, in turn, regulates cancer cell proliferation and metabolism .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ",", "in", "turn", ",", "regulates", "cancer", "cell", "proliferation", "and",...
PMC9429973	In the present study we retrospectively analyzed data from pts with primary ITP aged ≥60 years, who were diagnosed from 1979 to 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	A statistically significant (p<0.005) decrease in PRBC transfused in all 12-weeks’ intervals analyzed compared to baseline was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "statistically", ...
PMC10813895	In the U.S., BC ranks as the most common form of cancer among women .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "U.S.", ",", "BC", "ranks", "as", "the", ...
PMC11711066	Collectively, we found that As‐IV has inhibitory effects on vascular calcification similar to those of E2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "we", "found", "that", ...
PMC11583690	This is attributable to MSN's outer surface, which has numerous hydrophilic -OH groups, as well as uneven particle sizes, which limits DTX's adsorption capacity when compared with BPMO particles that lack -OH groups on the outer surface and are more evenly distributed .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	synMAPs harness a small microtubule-binding domain from oligodendrocytes (TPPP) whose activity we show can be rewired by interaction with unrelated condensate-forming IDR sequences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11774251	The pathogenesis of psoriasis is intricate, characterized by sustained inflammation and uncontrolled keratinocyte proliferation, with interaction involving genetic susceptibility and environmental factors.4,5 Treatments for psoriasis includes topical medications, systemic medications, phototherapy, and biologics.6 Howe...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301095	The patient's history showed in a local outdoor pond swimming in July and August of the same year.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patient", "'s", "history",...
PMC11116779	In the same way, but with a higher magnitude, IL1A, IL1B, IL6, and IL-8/CXCL8 mRNA levels were augmented when the cells were treated with the same concentrations of PS-NPs, and the effect is dose-dependent (Figures 4C–F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	FGF18 protein expression was significantly lower in VM21 and VM24 than in NM (181).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FGF18", "protein", "expression", "was", "significantly", ...
PMC10809689	Acute myeloid leukemia (AML) is the most common type of leukemia in adults and still has the lowest survival rate of all leukemia .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11757131	The addition of 3-HIB increased the expression of proteins related to de novo fatty acid synthesis and transport, resulting in a marked increase in most polyunsaturated fatty acids in the 3-HIB-added group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11438317	Monocytes/macrophages were removed by adherence to plastic overnight at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Monocytes/macrophages", "were", "removed", "by", "adherence", "to", "plastic", "overni...
PMC11387401	SupT1 cells were treated for 48 h with ASOs that specifically target H4C9, RPLP0, or AFF2 mRNA for degradation, before the cells were infected with GFP-tagged NL4.3 HIV-1. (	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9412887	In other words, this distinctive siRNAsome not only possessed an empty aqueous interior that could load hydrophilic agents, but also possessed a thermoresponsive and intracellular reduction-dependent hydrophobic median layer that could load hydrophobic drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352877	The VEGF-A/HIF-1α axis regulates tumor progression , as the hypoxic upregulation of VEGF-A is required to promote the angiogenic phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "VEGF-A/HIF-1α", "axis...
PMC11365983	In brief, after fixation in Dent’s solution, cilia and basal bodies of cells were immunofluorescently labelled using anti-Arl13b and anti-γ-tubulin antibodies respectively (see Supplemental methods for details).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11678448

The GO enrichment analysis of upregulated DEGs revealed that the biological processes that were significantly enriched primarily included cytokine-mediated signaling pathways and cellular responses to cytokine stimuli (Figure S1A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11462929

The top panel indicates amplification regions detected in 38 BCP‐ALL cell lines by the array copy number variation analyses using microarray dataset.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top",...

PMC11697065

To better dissect correlation data according to molecule format (monoclonal and bispecific antibodies) separate analysis was performed (Supplemental Figure 6A-H).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

Flow cytometry analysis was performed to detect T cell subsets of active ITP mice.

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PMC11750165

Cell lines were cultured at 37°C in a 5% CO2 incubator.

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PMC8751435

Effect of CME on lactate dehydrogenase release in A549 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Effect", "of", "CME", "on", "lactate", "dehydrogenase", "release", "in", "A549", "cells...

PMC6600592

Oximes (4A-1, 4B-1, 4C-1 and 4D-1) which R=H showed weaker anti-HBsAg and anti-HBeAg activities, weaker affinities to the selected target protein in docking than those compounds which R=Me and benzyl.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9111184

These modifications can be attributed to structural changes in DNA volume or density.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "modifications", "can", "be", "attributed", "to", "structural", "ch...

PMC10079526

LFQ intensities were Log2 transformed, right-sided Student’s t-test was (FDR 0.05 q-value) performed between His10-SUMO2 enriched samples and their parental control counterparts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9917080

Only when cells were treated with 5 μg/mL SeSo, up to 10% of astrocytes were recorded at the early stage of apoptosis (Figure 4C,F; Supplementary Figure S9).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Summary/Conclusion: CC-95251 + ritux demonstrated a manageable safety profile and promising efficacy in pts with heavily pretreated CD20+ R/R NHL.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion...

PMC10588957

The cell lysate was centrifuged at 12,000 × g at 4°C for 30 min to pellet the debris, and the protein concentration of the supernatant was estimated using a BCA Kit.

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PMC6684588

n = 7–11). (

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "7–11", ")", ".", "(" ] } ]

PMC11754432

There are six functional human LOX enzymes, named for the corresponding carbon of arachidonic acid (AA) in which molecular oxygen is inserted.

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PMC11593713

The activity of GR in the assessed samples was expressed as μmoles of NADPH utilized in 1 min per 1 mg of protein (IU/min/mg protein).

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PMC11806182

This study conducted an integrative analysis to identify miRNAs that may link PCOS with UCEC.

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PMC11429241

Other studies have shown very minimal scaffold coverage with cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "studies", "have", "shown", "very", "minimal", "scaffold", "coverage", "with", "cells", ...

PMC11740907

The material when heated above temperature of glass transition had released the stress that have been generated in the material.

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PMC10958426

Pairs are ranked by the interaction difference between normal tissue and tumor tissue.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pairs", "are", "ranked", "by", "the", "interaction", "difference", "between...

PMC9503669

Through these mechanisms, Nef allows HIV-infected cells to avoid immune surveillance by the host, prevents viral superinfection, and enhances viral infectivity and spread.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11343332

In this study, we examined pycnogenol's cytotoxic and pro-apoptotic effects on the breast cancer cell line MCF-7.

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PMC9429973

For severe CRS prediction, 4 patients were divided into two groups based on tumor burden.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "severe", "CRS", "prediction", ",", "4", "...

PMC7759933

Similarly, the expression of CYP1A2 remained constant from day 5 onwards.

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PMC11477621

To a solution of 2-acetyl pyrrole (109 mg, 1.00 mmol) in dry DMF (10 mL) was added NaH (44 mg, 60%, dispersion in paraffin liquid, 1.10 mmol) at 0 °C.

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PMC11322866

After overexpression of RRM2, we observed a relatively slight decrease in EZH2 protein level but a significant decrease in H3K27me3 level.

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PMC11078693

Work in a dimmed light environment for the remaining steps.

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PMC8009078

On the other hand, the binding energy of all molecules was explored after docking through ADV.

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PMC8735881

Error bars indicate the means ± standard deviations (SD). (

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PMC11604015

Two patients relapsed with CD7-negative malignant cells, which can be explained by preexisting CD7-low or CD7-negative blasts .

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PMC11607321

The result contains SHAP values in a multidimensional array with shapes of , where each represents the number of latent dimensions, samples and features, respectively.

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PMC6468656

Canonical pathway analysis was performed to identify Diseases and Disorders (Figure 1B) and Molecular and Cellular Function (Figure 1C) according to the matched differentially expressed genes in IPA database.

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PMC8427838

1Identification of moesin as a TMIGD1 binding protein: A Schematic of GST-TMIGD1 cytoplasmic domain and its expression.

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PMC9429973

R. M. Rifkin, C. L. Costello, R. E. Birhiray, S. Kambhampati, J. Richter, R. Abonour, H. C. Lee, Y. J. Kim, K. Ren, D. M. Stull, D. Cherepanov, K. Bogard, S. J. Noga, S. Girnius Rocky Mountain Cancer Centers/US Oncology Research, Denver; Moores Cancer Center, University of California San Diego, La Jolla; Hematology Onc...

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PMC11461833

STXBP5 shRNA sh1, STXBP5 sh2, STXBP6 sh1, and STXBP6 sh2 were individually cloned and inserted into the pSuper-puro plasmid.

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PMC9250505

4NPB synergizes with PARP inhibitors to decrease cell survival in patient-derived EOC organoids.

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PMC9429973

Overall, 48 pts (16%) were poor mobilizers: 14 (5%) failed to yield ≥2×10/Kg CD34, while 34 (11%) required rescue with PLX.

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PMC11476222

This highlights the complexity of gangliosides due to variation in the fatty acid chain length.

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PMC11628904

However, it is clear that a goal of such treatment should be to limit the spread of damage associated with burn wounds.

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PMC11730320

However, subsequent successful rearrangement of a TCRβ chain, followed by signaling in association with pTCRα, inhibits further γδ rearrangements and silences their expression.

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PMC3995603

Furthermore, treatment with AC reduced the plasma levels of histamine and IgE in D. farinae-sensitized Nc/Nga mice.

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PMC9429973

Examining the dynamic changes of the TCR repertoire between diagnosis and week 5 for each patient, we found that patients with allergy had a much less similar clonotypic set between timepoints compared to non-allergic patients (P=0.003, Figure 1E).

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PMC11783017

H–J) Representative images of H&E staining, immunofluorescence staining of TUNEL and immunohistochemical staining of Ki-67 in tumors. (

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PMC9221284

It is, therefore, very likely that the translation of Trans1 leads to the formation of c-Myc2 from the AUG initiation codon that is located at exon 2 (Figure 3 and Figure S4).

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PMC9429973

Results: TC consisted of 185 pts, of which 103 (55.7%) were male, and the median age at diagnosis was 47 years (Table 1).

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PMC8708099

To select the appropriate time of incubation with histamine, osthole, and FXF in the experiments, cell viability was assessed using a methyl thiazolyl tetrazolium (MTT) assay.

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PMC9817179

We note that the fixation-induced changes to LLPS appearance can affect the physical characterization of in vivo LLPS systems based on fixed-cell imaging, such as the Gibbs energy of transfer between dilute and concentrated phases (Riback et al., 2020) and how far from the critical concentration a system is (Bracha et ...

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PMC11612315

To ensure that exendin 20–29 does not interact with GLP-1R, we utilized an acute IPGTT.

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PMC11528603

The differences between mean values were analyzed by unpaired Student’s t-test.

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PMC11281366

To evaluate the impact of these miRNAs on the levels of CD59 mRNA and surface protein expression levels, we nucleofected either miRNAs-21, -26a or -29a mimics into primary CD4 T cells.

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PMC11770199

Tumor sizes were measured every other day and recorded for 24 d. NS versus mMSCs-p14, *P = 0.023; mMSCs-GFP versus mMSCs-p14, *P = 0.047 by one-way ANOVA with Dunnett’s multiple comparisons test (n = 6 animals). (

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PMC11678368

The most stable models of these complexes are shown in Figure 1a and d, respectively.

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PMC9429973

R. Thijssen, L. Tian, C. Flensburg, M. A. Anderson, A. Jarratt, H. Peng, I. Majewski, C. Tam, J. Seymour, P. Blombery, M. Ritchie, D. Huang, A. Roberts The Walter and Eliza Hall Institute of Medical Research; Medical Biology, University of Melbourne; Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Ca...

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PMC9429973

All patients presented MMR at last follow-up and 92.3% deep MMR (≥MR4).

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PMC11286266

To identify regulators of ATF6α a library of pooled lentiviral single-guide RNAs (sgRNAs) targeting 20,680 predicted protein-coding genes in CHO cells, with ~6 sgRNAs per gene, was used (Ordóñez et al., 2021).

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PMC11803149

This study demonstrated that aging significantly impairs anti-tumor responses of antigen-specific CD8 T cells in ACT using a mouse model of melanoma.

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PMC11514418

It has been confirmed in many in vitro and in vivo studies that APS can enhance immune activity, improve the local hematopoietic environment in the bone marrow, and accelerate stem cell proliferation, thereby inhibiting the occurrence and progression of tumors[19-21].

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PMC11591038

Besides neurodegeneration, glial activation is one of the early alterations during AD progression, possibly related to the deposition of Aβ resulting in gliosis .

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PMC10203589

Fgfr1-4 has a similar structure with three basic domains: extracellular, membrane and intracellular.

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PMC9672323

The effect of dexamethasone and piroxicam was measured on the IFN-γ levels of T cells in PBMCs alone (a, c), and in co-culture with U-87 (b) (n = 5), and A-172 (d) (n = 4) cells.

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PMC11634027

A-F) Wing discs from homozygous ds (A-C) or ds (D-F) stained for Ds:V5.

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PMC3931643

1×10 cells were harvested, fixed in 50% ethanol, washed and stained in 0.1 mg/ml propidium iodide (PI)-staining solution (Life Technologies, Grand Island, NY).

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PMC8540611

We have previously combined two types of systems by modifying gold nanoparticles with cationic carbosilane dendrons .

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PMC7338939

The temporary reduction of tumor growth was observed in both IT and IT + IV groups during 13 days of treatment.

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PMC9581083

TCM has accumulated much experience in dealing with this sort of disease over the centuries.

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PMC8777939

Cancer metastasis is the central cause of cancer therapy failure and mortality.

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PMC11765988

In cases of DISR, the diagnosis is confirmed by the resolution of lesions after discontinuing the treatment.

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PMC11736898

No statistically significant differences were observed among any of the normal keratinocyte groups, although the difference between untreated and ketoconazole-treated normal keratinocytes approached statistical significance (p = 0.05).

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PMC8592717

PAL was reported to inhibit the production of ROS in rat PC12 cells and human SH-SY5Y cells .

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PMC11655536

MM cell were seeded at a density of 5 × 10 /ml in 96-well plates.

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PMC11574271

Surprisingly, the levels of the HIF-2α protein were strongly correlated with the amount of RON in bladder cancer cells (Fig. 4C, D).

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PMC9429973

Patients with CLL and DLBCL diagnosis within a time interval of 3 months were defined as concurrent RS-DLBCL (concurrent RS).

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PMC7338939

Moreover, the Gompertz-based mathematical model determined a new drug resistance term in the present study.

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PMC11672881

Our study highlights the significant role of mitochondrial ROS generation and apoptotic signaling in mediating the anti-tumor effects of the combination.

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PMC8524093

Therefore, understanding the potentials and limitations of the state-of-the-art experimental models is imperative to advance in the field.

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PMC11470999

The cells were pre‐treated with CQ for 2 h, then PF was added for a further 24 h. (I) B16 and A375 cell stably expressing Flag‐CIP2A were transfected with an HA‐tagged ubiquitin expression plasmid (HA‐Ub).

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PMC9812014

Berberine can suppress IAV type A/PR/8/34 in the RAW-264.7 cells at over 1 μM, while the IC50 for berberine was 0.01 μM. This alkaloid also suppressed the growth of a separate strain of H1N1 IAV in vitro, with an IC50 of 0.44 μM. Berberine’s mode of action implies that it affects virus protein maturation as well as its...

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PMC11791478

Short tandem repeat profiling was conducted, whereas for interspecies contamination cytochrome oxidase 1 barcoding was used (ATCC) for intraspecies contamination of human and mouse cells.

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PMC11599565

Furthermore, a closer examination of the media compositions used for generating and culturing tumor-derived organoids reveals that nearly all, if not all, contain cytokines and factors that promote neuronal growth in vitro.

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PMC10968586

These effects might rely on inhibition of lipogenesis.

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PMC10890307

Instead, only a small amount of glutamine consumption was observed.

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PMC6803987

After 21 days of treatment with esculetin and 3TC, DHBV DNA levels of each group were lower when compared to the model group (* p < 0.05).

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PMC10808409

Cell cycle analysis revealed that Caco-2 cells treatment with IC50 of TPGS mixed micelles formula (O2) (17.1 µg/ml) resulted in cell cycle arrest at the S phase, whereas treatment with IC50 of FA (191 µg/ml) resulted in cell cycle arrest at G2/M phase and raised apoptosis (Table 4 and Fig. 5).

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PMC11775197

This, in turn, regulates cancer cell proliferation and metabolism .

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PMC9429973

In the present study we retrospectively analyzed data from pts with primary ITP aged ≥60 years, who were diagnosed from 1979 to 2021.

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PMC9429973

A statistically significant (p<0.005) decrease in PRBC transfused in all 12-weeks’ intervals analyzed compared to baseline was observed.

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PMC10813895

In the U.S., BC ranks as the most common form of cancer among women .

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PMC11711066

Collectively, we found that As‐IV has inhibitory effects on vascular calcification similar to those of E2.

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PMC11583690

This is attributable to MSN's outer surface, which has numerous hydrophilic -OH groups, as well as uneven particle sizes, which limits DTX's adsorption capacity when compared with BPMO particles that lack -OH groups on the outer surface and are more evenly distributed .

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PMC11342785

synMAPs harness a small microtubule-binding domain from oligodendrocytes (TPPP) whose activity we show can be rewired by interaction with unrelated condensate-forming IDR sequences.

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PMC11774251

The pathogenesis of psoriasis is intricate, characterized by sustained inflammation and uncontrolled keratinocyte proliferation, with interaction involving genetic susceptibility and environmental factors.4,5 Treatments for psoriasis includes topical medications, systemic medications, phototherapy, and biologics.6 Howe...

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PMC11301095

The patient's history showed in a local outdoor pond swimming in July and August of the same year.

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PMC11116779

In the same way, but with a higher magnitude, IL1A, IL1B, IL6, and IL-8/CXCL8 mRNA levels were augmented when the cells were treated with the same concentrations of PS-NPs, and the effect is dose-dependent (Figures 4C–F).

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PMC10203589

FGF18 protein expression was significantly lower in VM21 and VM24 than in NM (181).

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PMC10809689

Acute myeloid leukemia (AML) is the most common type of leukemia in adults and still has the lowest survival rate of all leukemia .

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PMC11757131

The addition of 3-HIB increased the expression of proteins related to de novo fatty acid synthesis and transport, resulting in a marked increase in most polyunsaturated fatty acids in the 3-HIB-added group.

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PMC11438317

Monocytes/macrophages were removed by adherence to plastic overnight at 37 °C.

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PMC11387401

SupT1 cells were treated for 48 h with ASOs that specifically target H4C9, RPLP0, or AFF2 mRNA for degradation, before the cells were infected with GFP-tagged NL4.3 HIV-1. (

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PMC9412887

In other words, this distinctive siRNAsome not only possessed an empty aqueous interior that could load hydrophilic agents, but also possessed a thermoresponsive and intracellular reduction-dependent hydrophobic median layer that could load hydrophobic drugs.

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PMC11352877

The VEGF-A/HIF-1α axis regulates tumor progression , as the hypoxic upregulation of VEGF-A is required to promote the angiogenic phenotype.

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PMC11365983

In brief, after fixation in Dent’s solution, cilia and basal bodies of cells were immunofluorescently labelled using anti-Arl13b and anti-γ-tubulin antibodies respectively (see Supplemental methods for details).

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