OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10237474	CM was filtered using a 0.45-μm membrane and loaded onto an affinity column coupled with a SEC column via the sample pump of AKTA (Cytiva).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	Next, we expanded and stocked three clones until PD30-40 (PD) and one clone (P3G4) until PD110-120 (PD) using a splitting ratio of 1:10 every week.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190062	The figure shows mean ± SEM of three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "figure", "shows", "mean", "±", "SEM", "of", "three", "independent", "experiments", ...
PMC11185260	N = 6/group. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "N", "=", "6/group", ".", "(" ] } ]
PMC11799978	Restoring the pH, using either sodium bicarbonate or disodium hydrogen phosphate, to a homeostatic level in the simulated TME directly activates the self-remodeling features of CAFs by limiting their proliferation and reducing the production of ECMs including TGF-β, collagen I, and α-SMA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706491	OD600 was automatically recorded every 10 min for 48 h using Gen5 software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OD600", "was", "automatically", "recorded", "every", "10", "min", "for", ...
PMC11640247	bin 2) (-) vs. WT, p = 0.84; (-) vs. R66W, p < 0.001; WT vs. R66W, p < 0.001. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	J KEGG pathway analyses were conducted on DEGs following EWS::FLI1 knockdown in ES cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "J", "KEGG", "pathway", "analyses", "were", "conducted", "on...
PMC10994876	Cellular proliferation and apoptosis are interconnected and contrasting evolutionary processes that play crucial roles in the progression and maturation of organisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cellular", "proliferati...
PMC8998437	The stained cells were analyzed using a BD FACSAria III flow cytometer (Becton Dickinson and Company, Franklin Lakes, NJ, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Non-relapse mortality (NRM) was higher in HSCT from UD 10/10, 9/10 and Haplo donors compared with those from MSD (HR= 1.75; 95% CI 1.16-2.63, P= 0.007, HR =2.22; 95% CI 1.29-3.83, P= 0.004 and HR=2.53; 95% CI 1.47-4.34, P=0.0008), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	Representative images of FRAP analysis of EGFP-TOP2B H58Y, H58Y/G180I, and H58Y/L185F. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "FRAP", "analysis", "of", "EGFP-TOP2B...
PMC11566417	The same letters on graphs indicate no statistically significant differences between groups Collectively, our findings show that the CM of immortalized MDECs maintained antimicrobial and pro-migratory potency over longer subpassages when compared to the CM of primary MDECs, and that the immortalization of MDECs did not...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Herein, we compared the TCR repertoire of CD8+ and CD4+ T cells in the bone marrow of patients with high risk MDS and AML and observed that despite the common features of these two disorders, there are significant differences in the TCR repertoire specifically in CD8+ T cells, especially concerning TCR diversity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	In these experiments, which utilized equimolar concentrations of LY3300054 and ipilimumab, IFNγ and IL2 secretion was substantially enhanced in the combination treatment compared to each of the single agents (Fig. 4a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912	Titers (presented as the number of focus-forming units [FFU] per milliliter) were back-calculated on the basis of the dilution of virus that yielded 50 to 200 foci per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241	Therefore, the role of CDH1, CDH2, COL1A1, SMAD3, and TWIST1 in cell–cell adhesion, ECM production, and signaling pathways may be integral to the success of tissue engineering strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Keratinocytes cultured at the air-liquid interphase with the presence of Ca can be used to create a more physiologically relevant 3D skin model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Keratin...
PMC7039683	Last, the Hu_400+ and Zf_467+ pairwise-alignment has more 5 bp-long blocks of perfect identity (five such blocks) relative to all five of the zebrafish controls (average two 5 bp-long blocs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11363012	Iridoids, monoterpene indole alkaloids, and phenylpropanoids all have unstable biosynthetic intermediates in the pathway, but none of these were observed in these scMS experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5941560	Interchromosomal translocations (center)Table 3Gene sets enriched for highly impacted genesGO: CHROMOSOME ORGANIZATION Overlap: 51/1009 p-value= 0.00011 Genes: APBB1, ATXN3, ATXN7, BAZ2A, BCORL1, BRD8, CDC14A, CDCA5, CDYL, CENPT, CLASP1, CREBBP, EHMT1, GATAD2B, GTF2H3, HDAC4, KAT2A, KDM5B, KIF23, KNTC1, MLH3, MSH2, NCA...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11116779	When confluent, cells were detached enzymatically with trypsin-ethylenediamine tetra-acetic acid (Trypsin–EDTA, Sigma-Aldrich) and subcultured into a new cell culture flask.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11748618	Hypermethylated sites were defined as β ≥ 0.7 and hypomethylated as β ≤ 0.3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hypermethylated", "sites", "were", "defined", "as", "β", "≥", "0...
PMC9261184	The facilities onboard the ship with gas-contacting equipment are as follows:LNG cargo containment system and associated pipework above the deck (including vents);the compressor room;the engine room (main and generator engines, GCU, and fuel delivery system);the reliquefaction facility; andthe loading/unloading manifol...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	± stdev is reported for compounds showing >90% inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "±", "stdev", "is", "reported", "for", "compounds", "showing", ">", "90", "%", "...
PMC9429973	Results: Three phase III RCT with total of 1362 patients were included for our analysis (Figure).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Three", "phase", ...
PMC11402217	Western blotting results (F) and the normalized quantitative results (G) of WNT signaling pathway related proteins in 143B cells after XD23 stimulation.(H–J) The immunofluorescence analysis of β-catenin in 143B cells after treated with XD23.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11665584	Less common cell types of the skin (melanocytes, adipocytes, interstitial fibroblasts, Merkel cells, etc.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Less", "common", "cell", ...
PMC11706297	The EGFR TK enzyme system from Promega (Promega V3831) was performed at 10 μM and 1 μM concentrations and the HER2 TK enzyme system from Promega (Promega V9381) was performed at 10 μM concentration as previously described [31,48–50].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	L. Mackintosh, A. Maglitto, C. Rodriguez Seoane, S. A. Mariani, A. G. Rossi, E. Dzierzak Centre For Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom Background: GPR56 (ADGRG1) is a widely expressed adhesion G-coupled protein receptor in humans and mice which is implicated to play a role in both...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11564322	The final concentration of DMSO in the culture medium was always 0.1%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "final", "concentration", "of", "DMSO", "in", "the", "culture", ...
PMC11046454	We next tested the feasibility of using another TME hallmark, low pH, to modulate the cancer-targeting specificity of Apt-CAR (Figure S38).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11306331	Light-based MBP recruitment can be quite potent, even matching the efficacy of 1,6-hexanediol, a broad-spectrum compound widely used for condensate disruption.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Light-b...
PMC10502403	Long-term persistence may boost the clinical development of γδ-T cell products.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Long-term", "persistence", "may", "boost", "the", "clinical", "development", "of", "γδ-T", ...
PMC11612794	Consistent with this result, Mis12C co-immunoprecipitated with CENP-T but not with CENP-T (Figure 1F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistent", "with", "this", "result", ",", ...
PMC9429973	In dose expansion, ~25 patients each will be enrolled in the following cohorts: (1) patients with CLL/SLL who have failed prior BTK inhibitor therapy; (2) patients with mantle cell lymphoma who have failed prior BTK inhibitor therapy; (3) patients with marginal zone lymphoma who have failed prior BTK inhibitor therapy;...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10317042	The human cell lines Hewga-CCS (CCS; RRID:CVCL_0J32), Asra-EPS (epithelioid sarcoma; RRID:CVCL_W949), Yamato-SS (synovial sarcoma; RRID:CVCL_6C44), and Kitra-SRS (CIC-DUX4 sarcoma; RRID:CVCL_YI69) were established in our laboratory.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Our study point out that: 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "Our", "study", "point", "out", "that", ":", ...
PMC11730320	The TaqMan copy number reference assay based on human RNase P was used as an endogenous control for calibration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TaqMan", "copy", "number",...
PMC8414691	It is well known that defective mitosis or cytokinesis can cause chromosomal instability leading to genetically unstable states, hence activating tumorigenic transformation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC11772585	However, further validation is needed to determine the expression and impact of METTL1 on cutaneous basal cell carcinoma, which is the most common skin cancer and is characterized by relatively low levels of malignancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	The payload should also remain stable in the cytoplasm and lysosome without significant degradations under low pH conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "payload", "should", "also", "re...
PMC11541241	The biotrophic phytopathogenic fungus Ustilago maydis infects most of the grasses including barley, maize, wheat, and sugar cane (Brefort et al., 2009; Djamei, 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	We also assessed whether maintenance of cap dependent translation upon mTOR inhibition in VAL cells correlates with protein levels of cap dependent transcripts like MCL-1 and Cyclin D3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	The simultaneous use of T. dioica-facilitated CuO NPs and 5-Fu in a gel formulation (PXFCu gel) presents a hopeful, promising approach for targeted drug administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	To identify genes whose loss of function suppressed MYCN-driven neuroblastoma, we subjected homozygous male TH-MYCN mice to random ENU mutagenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "identify", ...
PMC11750165	Target sequence of sgRNA for genomic editing was designed based on the exon which has start codon of PEX1 (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Target", "se...
PMC8996378	SAR studies on macrocyclic diterpenes emphasized the importance of an aromatic moiety for ABCB1 binding, through electronic and steric interactions (Reis et al., 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10578720	Finally, we used PBMCs collected from patients with chronic HBV infection whose characteristic was showed in Supplemental Table S1, http://links.lww.com/HC9/A642 to further validate the effect of DCA treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Both, serum albumin <3.5 g/dL and a NLR >2.15 were independently associated with worse OS (adjusted, aHR 2.48 [1.26-4.91], p=0.009; and 2.55 [1.21-5.37], p=0.014) and PFS (aHR 1.62 [1.03-2.55], p=0.038; 2.22 [1.45-3.40], p<0.001), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11139449	The knockout of the CASP8AP2 gene in CHO cells was subsequently verified through PCR and sequencing analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "knockout", "of", "the", "CASP8AP2...
PMC9429973	Transfusion avoidance was maintained in 83.6% of patients during SC treatment, and 79.7% achieved stabilized hemoglobin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfusion", "avoidance", "was", ...
PMC11681005	In the hyperDMR sets, MIBC‐hyperDMR group 8 (hyperC8) comprised FOXA1‐bound, H3K27ac/H3K4me3‐high enhancers (Figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "hyperDMR", ...
PMC11477621	C NMR (100 MHz, CDCl3) δ 173.7, (159.0, 156.7), 132.7, 129.4, (128.9, 128.8), (110.0, 109.7), (109.96, 109.94), (105.8, 105.5), (101.0, 100.9), 60.3, 46.6, 34.3, 30.1, 28.8, 26.7, 24.9, 14.4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541241	This situation may indicate rewriting of this pathway in B. graminis f. sp. tritici.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "situation", "may", "indicate", "rewriting", "of", "this", ...
PMC11763111	D The plots present the proportion of lysed UCAR-T cells (n = 3) when autologous primary NK cells and donor UCAR-T cells were co-cultured at different E:T ratios over a 24-h period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	Tumor tissues compared to normal tissues. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "tissues", "compared", "to", "normal", "tissues", ".", "(" ] } ]
PMC9024365	As GluA1/2 heteromers constitute 95% of extrasynaptic AMPAR pool under baseline conditions (Lu et al., 2009), this suggests that SD4 is required to maintain extrasynaptic GluA1/2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	The CAGE data across the LCL panel therefore give us a unique opportunity to both estimate variability in promoter activity and characterize the regulatory features influencing such variability. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Copy number variations (CNVs) of TRAF3 were assessed by a NGS approach and validated by SNP Array 6.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Copy", "number", "variations...
PMC8303372	To verify both the stability of GA during the time and the absence of a strong interaction between GA and NPs an in vitro release study in ethanol (a well-known GA solvent) was performed with the same procedure utilized in PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9268620	Exactly 1.02 g of nordamnacanthal was isolated after the recovery of the major orange band.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exactly", "1.02", "g", "of", "nordamnacanthal", "was", "iso...
PMC10877303	However, among them, Helichrysetin, Herbacetin, and isobavachalcone did not bind with the residues of the active site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "a...
PMC11746948	We overexpressed wild-type GPX4 (GPX4-WT), GPX4-C66S, and GPX4-C75S mutants in A375 cells and observed that 2-BP reduced levels of endogenous GPX4, GPX4-WT, and GPX4-C75S, but not GPX4-C66S (Fig. 3p, q), highlighting C66 as a crucial palmitoylation site for GPX4 stability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9031474	They are 15-carbon compounds derived from the assembly of three isoprenoid units and can be subdivided into acyclic, monocyclic, bicyclic, and tricyclic derivatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11794847	While they can engage in glycolysis, they predominantly depend on lipid oxidation and mitochondrial respiration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "they", "can", "engage", "in", "glycolysis", ...
PMC11047729	Sodium butyrate also shows anti-cancer abilities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sodium", "butyrate", "also", "shows", "anti-cancer", "abilities", "." ] } ]
PMC10198699	In the first scenario, it is assumed that all involved act lawfully, and the hypothetical present-day Henrietta Lacks gives informed consent in writing for the removal of a tissue sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597	Daidzin is a naturally occurring product from Kudzu roots that inhibits aldehyde dehydrogenase‐2, an enzyme crucial to alcohol metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Daidzin", "is", "a", "...
PMC9429973	Summary/Conclusion: We demonstrate that the previously uncharacterized long non-coding RNA LINC01547 has wide-ranging functions in AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "We", "demonstrate", "t...
PMC11473843	The cDNA libraries were evaluated using a Thermo Fisher Scientific Qubit 4.0 fluorometer with the Qubit dsDNA HS Assay Kit (Thermo Fisher Scientific, Q32854 and an Agilent Fragment Analyzer (Agilent) with a HS NGS Fragment Kit (Agilent, DNF-474), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	To understand the mechanisms through which EFNB2 promotes multiple myeloma growth, we performed RNA-seq on multiple myeloma cells treated with sh-RNA-EFNB2 versus multiple myeloma cells treated with sh-Control (Fig. 4A; Supplementary Fig. S4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	Experimental evidence supports a pro-oxidant action of low doses of HT in colorectal cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experimental", "evidence", "supports", "a", "pro-oxidant", "actio...
PMC8750422	After 4 h of incubation, the medium was changed to complete medium, and 48 h following transfection, overexpression was confirmed by western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Z. Miltényi, A. E. Dr Gál, D. Tóthfalusi, Á. Prof Dr Illés Hematology, University of Debrecen, Debrecen, Hungary Background: The majority of patients with myelodysplasia (MDS) are over 70 years of age, so the only curative treatment, allogeneic stem cell transplantation, can be given to only a few patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	CATR, a conformational inhibitor of ANT3, increases chemosensitivity in EFHD1-positive cells when used in combination with cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CATR", ",", "a", "conformational"...
PMC11269933	Furthermore, the MAPK-PK pathway responded to temperature elevation and exhibited inter-species differentiation in two species during reciprocal transplant experiment, indicating its involvement in temperature adaptation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9100622	The observation that EWSR1-FLI1 and EGR2 regulate enzymes of the MVA pathway prompted us to investigate whether Ewing cells’ growth may be dependent upon this pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3765139	The MGP expression in CD133- D10 cells was identified as a calibrator sample and the CD133+ sample expressed n-fold mRNA relative to the calibrator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Summary/Conclusion: We suggested a powerful Integral Transformation Index to distinguish cases of low-grade lymphomas transformation into high-grade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "We", "suggested",...
PMC6190245	The current study explores cytotoxic and apoptogenic properties of F. gummosa, when administered in combination with radiation, in the HeLa cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "token...
PMC11774112	At present, the incidence of most solid tumors is decreasing or remaining the same, but the incidence of MM continues to increase.1 There is no effective treatment for MM (the 5-year survival rate is <15%, and the mean median survival time is only 6 months).2 Surgical resection is the primary therapeutic option for mel...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	The capacity of MSCs to bind to P-selectin in vitro is enhanced by polymer coating with sialyl-Lewis X and chemical conjugation of the MSC cell surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9220170	When studying the effect of SELENOT-KD on the expression patterns of the above genes, it was also important to take into account the conditions of acute ER stress caused by 0.1 μM MSA since this inducer increased mRNA expression in A-172 cells by more than two times .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Proteasome activity was increased in the FLAG-PSMD14 immunoprecipitates that had been treated with HDAC6 inhibitors relative to controls (Fig. 5N).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteasome", ...
PMC11700247	Working model: time line and schematic representation of in vivo A20 tumor–bearing mice treated with RT followed by CART-19 cell injection with or without the STING antagonist H-151.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11337594	A375-Control/CASP3-KO cells were treated with different doses of TER (0, 1.0, 2.0, and 3.0 µg/ml) for 24 h, after which LDH release was determined (n = 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10571053	Control cells (no antibody) are denoted by red curves, isotype control staining is denoted by blue curves, and P-gp staining is denoted by orange curves (ABCG2 top row, P-gp bottom row).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11366496	Dalton et al. reported a convergence between the cell cycle and c‐Myc regarding the regulatory mechanisms that govern pluripotency and reprogramming.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dalton", "et", "a...
PMC10919056	The separated proteins were then transferred onto polyvinylidene fluoride (PVDF) membranes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "separated", "proteins", "were", "then", "transferred", "onto", "poly...
PMC9509578	Zhao et al. demonstrated the co-delivery of curcumin and paclitaxel via core–shell polymeric NPs in human ovarian cancer SKOV3 and SKOV3-TR30 cells and in tumor-bearing xenograft mice to reverse drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "...
PMC10237474	Zoom-in spectrum of (B) from a deconvoluted mass range of 16260 to 16640 Da.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zoom-in", "spectrum", "of", "(", "B", ")", "from...
PMC11597291	To further evaluate the in vitro anticancer activity of the nCGO-PEG/PCT particles, their effect on cellular apoptosis was investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "evaluate", ...
PMC11653533	Since a binding affinity of −9 kcal/mol generally indicates strong interaction with a receptor, these findings suggest that moretenol may exert significant antimicrobial effects against both Gram-positive and Gram-negative bacteria (Hasnat et al., 2023, Taher et al., 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	The increased sensitivity of CRC0254 relative to CRC0177 may be explained by BMS‐754807‐mediated inhibition of MET, which was inferred to have a high activity in CRC0254 but less so in CRC0177 (see panel A).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10006224	p < 2e−16.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "<", "2e−16", "." ] } ]
PMC11023271	The concentration of LPA in serum is typically around 10 μM , so 10 μM LPA was added onto serum-starved HaCaT and A431 monolayers and found to down-regulate RIPK4 mRNA (Fig 6A and 6B, left panels) to a similar extent as serum or BSA (Fig 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "...
PMC9429973	Thirteen patients were enrolled from March 2021 to January 2022, with a median follow-up of 7.0 (1.5-10.5) months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thirtee...
PMC11487720	The dye was decanted, and the total cells and trypan blue-positive cells were counted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dye", "was", "decanted", ",", "and", "the", "t...
PMC4270159	1 µM PLX4032 + no ligand.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "µM", "PLX4032", "+", "no", "ligand", "." ] } ]

PMC10237474

CM was filtered using a 0.45-μm membrane and loaded onto an affinity column coupled with a SEC column via the sample pump of AKTA (Cytiva).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10114490

Next, we expanded and stocked three clones until PD30-40 (PD) and one clone (P3G4) until PD110-120 (PD) using a splitting ratio of 1:10 every week.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11190062

The figure shows mean ± SEM of three independent experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "figure", "shows", "mean", "±", "SEM", "of", "three", "independent", "experiments", ...

PMC11185260

N = 6/group. (

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "N", "=", "6/group", ".", "(" ] } ]

PMC11799978

Restoring the pH, using either sodium bicarbonate or disodium hydrogen phosphate, to a homeostatic level in the simulated TME directly activates the self-remodeling features of CAFs by limiting their proliferation and reducing the production of ECMs including TGF-β, collagen I, and α-SMA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11706491

OD600 was automatically recorded every 10 min for 48 h using Gen5 software.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OD600", "was", "automatically", "recorded", "every", "10", "min", "for", ...

PMC11640247

bin 2) (-) vs. WT, p = 0.84; (-) vs. R66W, p < 0.001; WT vs. R66W, p < 0.001. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11453018

J KEGG pathway analyses were conducted on DEGs following EWS::FLI1 knockdown in ES cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "J", "KEGG", "pathway", "analyses", "were", "conducted", "on...

PMC10994876

Cellular proliferation and apoptosis are interconnected and contrasting evolutionary processes that play crucial roles in the progression and maturation of organisms.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cellular", "proliferati...

PMC8998437

The stained cells were analyzed using a BD FACSAria III flow cytometer (Becton Dickinson and Company, Franklin Lakes, NJ, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9429973

Non-relapse mortality (NRM) was higher in HSCT from UD 10/10, 9/10 and Haplo donors compared with those from MSD (HR= 1.75; 95% CI 1.16-2.63, P= 0.007, HR =2.22; 95% CI 1.29-3.83, P= 0.004 and HR=2.53; 95% CI 1.47-4.34, P=0.0008), respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9712534

Representative images of FRAP analysis of EGFP-TOP2B H58Y, H58Y/G180I, and H58Y/L185F. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "FRAP", "analysis", "of", "EGFP-TOP2B...

PMC11566417

The same letters on graphs indicate no statistically significant differences between groups Collectively, our findings show that the CM of immortalized MDECs maintained antimicrobial and pro-migratory potency over longer subpassages when compared to the CM of primary MDECs, and that the immortalization of MDECs did not...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Herein, we compared the TCR repertoire of CD8+ and CD4+ T cells in the bone marrow of patients with high risk MDS and AML and observed that despite the common features of these two disorders, there are significant differences in the TCR repertoire specifically in CD8+ T cells, especially concerning TCR diversity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5925824

In these experiments, which utilized equimolar concentrations of LY3300054 and ipilimumab, IFNγ and IL2 secretion was substantially enhanced in the combination treatment compared to each of the single agents (Fig. 4a).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9847912

Titers (presented as the number of focus-forming units [FFU] per milliliter) were back-calculated on the basis of the dilution of virus that yielded 50 to 200 foci per well.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11429241

Therefore, the role of CDH1, CDH2, COL1A1, SMAD3, and TWIST1 in cell–cell adhesion, ECM production, and signaling pathways may be integral to the success of tissue engineering strategies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11754432

Keratinocytes cultured at the air-liquid interphase with the presence of Ca can be used to create a more physiologically relevant 3D skin model.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Keratin...

PMC7039683

Last, the Hu_400+ and Zf_467+ pairwise-alignment has more 5 bp-long blocks of perfect identity (five such blocks) relative to all five of the zebrafish controls (average two 5 bp-long blocs).

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PMC11363012

Iridoids, monoterpene indole alkaloids, and phenylpropanoids all have unstable biosynthetic intermediates in the pathway, but none of these were observed in these scMS experiments.

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PMC5941560

Interchromosomal translocations (center)Table 3Gene sets enriched for highly impacted genesGO: CHROMOSOME ORGANIZATION Overlap: 51/1009 p-value= 0.00011 Genes: APBB1, ATXN3, ATXN7, BAZ2A, BCORL1, BRD8, CDC14A, CDCA5, CDYL, CENPT, CLASP1, CREBBP, EHMT1, GATAD2B, GTF2H3, HDAC4, KAT2A, KDM5B, KIF23, KNTC1, MLH3, MSH2, NCA...

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PMC11116779

When confluent, cells were detached enzymatically with trypsin-ethylenediamine tetra-acetic acid (Trypsin–EDTA, Sigma-Aldrich) and subcultured into a new cell culture flask.

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PMC11748618

Hypermethylated sites were defined as β ≥ 0.7 and hypomethylated as β ≤ 0.3.

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PMC9261184

The facilities onboard the ship with gas-contacting equipment are as follows:LNG cargo containment system and associated pipework above the deck (including vents);the compressor room;the engine room (main and generator engines, GCU, and fuel delivery system);the reliquefaction facility; andthe loading/unloading manifol...

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PMC11696576

± stdev is reported for compounds showing >90% inhibition.

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PMC9429973

Results: Three phase III RCT with total of 1362 patients were included for our analysis (Figure).

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PMC11402217

Western blotting results (F) and the normalized quantitative results (G) of WNT signaling pathway related proteins in 143B cells after XD23 stimulation.(H–J) The immunofluorescence analysis of β-catenin in 143B cells after treated with XD23.

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PMC11665584

Less common cell types of the skin (melanocytes, adipocytes, interstitial fibroblasts, Merkel cells, etc.)

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PMC11706297

The EGFR TK enzyme system from Promega (Promega V3831) was performed at 10 μM and 1 μM concentrations and the HER2 TK enzyme system from Promega (Promega V9381) was performed at 10 μM concentration as previously described [31,48–50].

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PMC9429973

L. Mackintosh, A. Maglitto, C. Rodriguez Seoane, S. A. Mariani, A. G. Rossi, E. Dzierzak Centre For Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom Background: GPR56 (ADGRG1) is a widely expressed adhesion G-coupled protein receptor in humans and mice which is implicated to play a role in both...

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PMC11564322

The final concentration of DMSO in the culture medium was always 0.1%.

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PMC11046454

We next tested the feasibility of using another TME hallmark, low pH, to modulate the cancer-targeting specificity of Apt-CAR (Figure S38).

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PMC11306331

Light-based MBP recruitment can be quite potent, even matching the efficacy of 1,6-hexanediol, a broad-spectrum compound widely used for condensate disruption.

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PMC10502403

Long-term persistence may boost the clinical development of γδ-T cell products.

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PMC11612794

Consistent with this result, Mis12C co-immunoprecipitated with CENP-T but not with CENP-T (Figure 1F).

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PMC9429973

In dose expansion, ~25 patients each will be enrolled in the following cohorts: (1) patients with CLL/SLL who have failed prior BTK inhibitor therapy; (2) patients with mantle cell lymphoma who have failed prior BTK inhibitor therapy; (3) patients with marginal zone lymphoma who have failed prior BTK inhibitor therapy;...

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PMC10317042

The human cell lines Hewga-CCS (CCS; RRID:CVCL_0J32), Asra-EPS (epithelioid sarcoma; RRID:CVCL_W949), Yamato-SS (synovial sarcoma; RRID:CVCL_6C44), and Kitra-SRS (CIC-DUX4 sarcoma; RRID:CVCL_YI69) were established in our laboratory.

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PMC9429973

Image: Summary/Conclusion: Our study point out that: 1.

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PMC11730320

The TaqMan copy number reference assay based on human RNase P was used as an endogenous control for calibration.

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PMC8414691

It is well known that defective mitosis or cytokinesis can cause chromosomal instability leading to genetically unstable states, hence activating tumorigenic transformation .

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PMC11772585

However, further validation is needed to determine the expression and impact of METTL1 on cutaneous basal cell carcinoma, which is the most common skin cancer and is characterized by relatively low levels of malignancy.

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PMC10547921

The payload should also remain stable in the cytoplasm and lysosome without significant degradations under low pH conditions.

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PMC11541241

The biotrophic phytopathogenic fungus Ustilago maydis infects most of the grasses including barley, maize, wheat, and sugar cane (Brefort et al., 2009; Djamei, 2023).

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PMC3931643

We also assessed whether maintenance of cap dependent translation upon mTOR inhibition in VAL cells correlates with protein levels of cap dependent transcripts like MCL-1 and Cyclin D3.

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PMC11680562

The simultaneous use of T. dioica-facilitated CuO NPs and 5-Fu in a gel formulation (PXFCu gel) presents a hopeful, promising approach for targeted drug administration.

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PMC11473750

To identify genes whose loss of function suppressed MYCN-driven neuroblastoma, we subjected homozygous male TH-MYCN mice to random ENU mutagenesis.

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PMC11750165

Target sequence of sgRNA for genomic editing was designed based on the exon which has start codon of PEX1 (A).

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PMC8996378

SAR studies on macrocyclic diterpenes emphasized the importance of an aromatic moiety for ABCB1 binding, through electronic and steric interactions (Reis et al., 2013).

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PMC10578720

Finally, we used PBMCs collected from patients with chronic HBV infection whose characteristic was showed in Supplemental Table S1, http://links.lww.com/HC9/A642 to further validate the effect of DCA treatment.

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PMC9429973

Both, serum albumin <3.5 g/dL and a NLR >2.15 were independently associated with worse OS (adjusted, aHR 2.48 [1.26-4.91], p=0.009; and 2.55 [1.21-5.37], p=0.014) and PFS (aHR 1.62 [1.03-2.55], p=0.038; 2.22 [1.45-3.40], p<0.001), respectively.

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PMC11139449

The knockout of the CASP8AP2 gene in CHO cells was subsequently verified through PCR and sequencing analysis.

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PMC9429973

Transfusion avoidance was maintained in 83.6% of patients during SC treatment, and 79.7% achieved stabilized hemoglobin.

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PMC11681005

In the hyperDMR sets, MIBC‐hyperDMR group 8 (hyperC8) comprised FOXA1‐bound, H3K27ac/H3K4me3‐high enhancers (Figure 1C).

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PMC11477621

C NMR (100 MHz, CDCl3) δ 173.7, (159.0, 156.7), 132.7, 129.4, (128.9, 128.8), (110.0, 109.7), (109.96, 109.94), (105.8, 105.5), (101.0, 100.9), 60.3, 46.6, 34.3, 30.1, 28.8, 26.7, 24.9, 14.4.

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PMC11541241

This situation may indicate rewriting of this pathway in B. graminis f. sp. tritici.

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PMC11763111

D The plots present the proportion of lysed UCAR-T cells (n = 3) when autologous primary NK cells and donor UCAR-T cells were co-cultured at different E:T ratios over a 24-h period.

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PMC11525028

Tumor tissues compared to normal tissues. (

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PMC9024365

As GluA1/2 heteromers constitute 95% of extrasynaptic AMPAR pool under baseline conditions (Lu et al., 2009), this suggests that SD4 is required to maintain extrasynaptic GluA1/2.

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PMC9844987

The CAGE data across the LCL panel therefore give us a unique opportunity to both estimate variability in promoter activity and characterize the regulatory features influencing such variability. (

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PMC9429973

Copy number variations (CNVs) of TRAF3 were assessed by a NGS approach and validated by SNP Array 6.0.

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PMC8303372

To verify both the stability of GA during the time and the absence of a strong interaction between GA and NPs an in vitro release study in ethanol (a well-known GA solvent) was performed with the same procedure utilized in PBS.

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PMC9268620

Exactly 1.02 g of nordamnacanthal was isolated after the recovery of the major orange band.

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PMC10877303

However, among them, Helichrysetin, Herbacetin, and isobavachalcone did not bind with the residues of the active site.

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PMC11746948

We overexpressed wild-type GPX4 (GPX4-WT), GPX4-C66S, and GPX4-C75S mutants in A375 cells and observed that 2-BP reduced levels of endogenous GPX4, GPX4-WT, and GPX4-C75S, but not GPX4-C66S (Fig. 3p, q), highlighting C66 as a crucial palmitoylation site for GPX4 stability.

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PMC9031474

They are 15-carbon compounds derived from the assembly of three isoprenoid units and can be subdivided into acyclic, monocyclic, bicyclic, and tricyclic derivatives.

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PMC11794847

While they can engage in glycolysis, they predominantly depend on lipid oxidation and mitochondrial respiration.

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PMC11047729

Sodium butyrate also shows anti-cancer abilities.

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PMC10198699

In the first scenario, it is assumed that all involved act lawfully, and the hypothetical present-day Henrietta Lacks gives informed consent in writing for the removal of a tissue sample.

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PMC11789597

Daidzin is a naturally occurring product from Kudzu roots that inhibits aldehyde dehydrogenase‐2, an enzyme crucial to alcohol metabolism.

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PMC9429973

Summary/Conclusion: We demonstrate that the previously uncharacterized long non-coding RNA LINC01547 has wide-ranging functions in AML.

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PMC11473843

The cDNA libraries were evaluated using a Thermo Fisher Scientific Qubit 4.0 fluorometer with the Qubit dsDNA HS Assay Kit (Thermo Fisher Scientific, Q32854 and an Agilent Fragment Analyzer (Agilent) with a HS NGS Fragment Kit (Agilent, DNF-474), respectively.

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PMC10940855

To understand the mechanisms through which EFNB2 promotes multiple myeloma growth, we performed RNA-seq on multiple myeloma cells treated with sh-RNA-EFNB2 versus multiple myeloma cells treated with sh-Control (Fig. 4A; Supplementary Fig. S4A).

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PMC10968586

Experimental evidence supports a pro-oxidant action of low doses of HT in colorectal cancer cells.

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PMC8750422

After 4 h of incubation, the medium was changed to complete medium, and 48 h following transfection, overexpression was confirmed by western blotting.

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PMC9429973

Z. Miltényi, A. E. Dr Gál, D. Tóthfalusi, Á. Prof Dr Illés Hematology, University of Debrecen, Debrecen, Hungary Background: The majority of patients with myelodysplasia (MDS) are over 70 years of age, so the only curative treatment, allogeneic stem cell transplantation, can be given to only a few patients.

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PMC11127909

CATR, a conformational inhibitor of ANT3, increases chemosensitivity in EFHD1-positive cells when used in combination with cisplatin.

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PMC11269933

Furthermore, the MAPK-PK pathway responded to temperature elevation and exhibited inter-species differentiation in two species during reciprocal transplant experiment, indicating its involvement in temperature adaptation.

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PMC9100622

The observation that EWSR1-FLI1 and EGR2 regulate enzymes of the MVA pathway prompted us to investigate whether Ewing cells’ growth may be dependent upon this pathway.

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PMC3765139

The MGP expression in CD133- D10 cells was identified as a calibrator sample and the CD133+ sample expressed n-fold mRNA relative to the calibrator.

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PMC9429973

Summary/Conclusion: We suggested a powerful Integral Transformation Index to distinguish cases of low-grade lymphomas transformation into high-grade.

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PMC6190245

The current study explores cytotoxic and apoptogenic properties of F. gummosa, when administered in combination with radiation, in the HeLa cell line.

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PMC11774112

At present, the incidence of most solid tumors is decreasing or remaining the same, but the incidence of MM continues to increase.1 There is no effective treatment for MM (the 5-year survival rate is <15%, and the mean median survival time is only 6 months).2 Surgical resection is the primary therapeutic option for mel...

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PMC10976516

The capacity of MSCs to bind to P-selectin in vitro is enhanced by polymer coating with sialyl-Lewis X and chemical conjugation of the MSC cell surface.

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PMC9220170

When studying the effect of SELENOT-KD on the expression patterns of the above genes, it was also important to take into account the conditions of acute ER stress caused by 0.1 μM MSA since this inducer increased mRNA expression in A-172 cells by more than two times .

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PMC11188874

Proteasome activity was increased in the FLAG-PSMD14 immunoprecipitates that had been treated with HDAC6 inhibitors relative to controls (Fig. 5N).

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PMC11700247

Working model: time line and schematic representation of in vivo A20 tumor–bearing mice treated with RT followed by CART-19 cell injection with or without the STING antagonist H-151.

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PMC11337594

A375-Control/CASP3-KO cells were treated with different doses of TER (0, 1.0, 2.0, and 3.0 µg/ml) for 24 h, after which LDH release was determined (n = 4).

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PMC10571053

Control cells (no antibody) are denoted by red curves, isotype control staining is denoted by blue curves, and P-gp staining is denoted by orange curves (ABCG2 top row, P-gp bottom row).

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PMC11366496

Dalton et al. reported a convergence between the cell cycle and c‐Myc regarding the regulatory mechanisms that govern pluripotency and reprogramming.

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PMC10919056

The separated proteins were then transferred onto polyvinylidene fluoride (PVDF) membranes.

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PMC9509578

Zhao et al. demonstrated the co-delivery of curcumin and paclitaxel via core–shell polymeric NPs in human ovarian cancer SKOV3 and SKOV3-TR30 cells and in tumor-bearing xenograft mice to reverse drug resistance.

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PMC10237474

Zoom-in spectrum of (B) from a deconvoluted mass range of 16260 to 16640 Da.

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PMC11597291

To further evaluate the in vitro anticancer activity of the nCGO-PEG/PCT particles, their effect on cellular apoptosis was investigated.

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PMC11653533

Since a binding affinity of −9 kcal/mol generally indicates strong interaction with a receptor, these findings suggest that moretenol may exert significant antimicrobial effects against both Gram-positive and Gram-negative bacteria (Hasnat et al., 2023, Taher et al., 2024).

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PMC6461034

The increased sensitivity of CRC0254 relative to CRC0177 may be explained by BMS‐754807‐mediated inhibition of MET, which was inferred to have a high activity in CRC0254 but less so in CRC0177 (see panel A).

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PMC10006224

p < 2e−16.

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PMC11023271

The concentration of LPA in serum is typically around 10 μM , so 10 μM LPA was added onto serum-starved HaCaT and A431 monolayers and found to down-regulate RIPK4 mRNA (Fig 6A and 6B, left panels) to a similar extent as serum or BSA (Fig 5).

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PMC9429973

Thirteen patients were enrolled from March 2021 to January 2022, with a median follow-up of 7.0 (1.5-10.5) months.

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PMC11487720

The dye was decanted, and the total cells and trypan blue-positive cells were counted.

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PMC4270159

1 µM PLX4032 + no ligand.

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