OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10454535	The tubes were incubated in the dark for 15 min at room temperature on a benchtop shaker.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tubes", "were", "incubated", "in", "...
PMC11363012	The cells were then collected in 96-well plates compatible with the autosampler of an UHPLC-HRMS system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "collected", "in", ...
PMC9429973	Subsequently, CEBPE takes over and directs sequential promotor-driven cell cycle exit by (i) launching a MYC – MAD switch leading to inhibition of G1/S gene expression, (ii) repression of E2F-meditated G2/M gene expression, and (iii) up-regulation of Cdk1/2/4inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673128	In this work, we provided preclinical evidence supporting the efficacy of combining TKIs with anti-CD47 mAb in both blood and solid ALK-positive cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9727330	Hany Khalil designed the research plan, supervised overall research, provided and interpreted data and wrote the manuscript.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hany", "Khalil", "designed", "the...
PMC9712534	Subsequent studies have demonstrated that these missense mutations in the catalytic domain lead to a significant decrease in the catalytic activity of TOP2B.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequ...
PMC11228511	Human lamin A formed a meshwork with uniform gaps of ~0.085 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "lamin", "A", "formed", "a", "meshwork", "with", "uniform", "gaps", ...
PMC11342785	Nearly identical results were observed using untagged constructs and DIC microscopy to visualize these droplets (Figs. 1C and S1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nearly", "identical", ...
PMC11726183	We then performed the docking studies using the XP-docking protocol (extra precision) with all other default parameters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "performed", "the", ...
PMC10933092	The ceRNA network (Figure 8C) was constructed via Cytoscape 3.9.1, and included 15 lncRNAs (seven upregulated and eight downregulated; sh-TRMT61A 5637 cells vs. sh-NC 5637 cells), 8 mRNAs (four upregulated and four downregulated; sh-TRMT61A 5637 cells vs. sh-NC 5637 cells), and 118 miRNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7215832	Results: RX-3117 treatment decreased total DNA-cytosine-methylation in A549 non-small cell lung cancer (NSCLC) cells, and induced protein expression of MGMT, p16 and E-cadherin in A549 and SW1573 NSCLC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11138140	A two-dimensional increase in surface area due to cell spreading is not indicative of a three-dimensional increase in cell volume.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "two-dimensional", "incr...
PMC11787651	The dashed line denotes a fold change of 2 in either direction, whereas the horizontal line indicates the significance threshold (p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11190238	Plasticity and fluidity of cell fate determination or EMT execution is thus dictated by the balance between different regulatory circuits governing the genome architecture, epigenetic modifications, transcription, translation, and post-translational modifications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727638	After leaving it to stand at 15 °C for 5 min, the Cell Domes formed on the glass plate were immersed in the medium containing 4000 U/mL catalase (from bovine liver; Fujifilm Wako Chemical).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The most common co-mutations were NPM1 (53%, 8/15), DNMT3A (27%, 4/15), IDH1 (20%, 3/15) and IDH2 (20%, 3/15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9351137	Moreover, INO80, Pontin, Reptin, and Tip60 chromatin remodelers were shown to relocate to the mitotic apparatus and suggested to play direct roles in cell division in human cells [24–29].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267036	Research has revealed that the STAT1/RIG-I axis plays a significant part in anti-tumor processes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "has", "revealed", "that", "the", "STAT1/RIG-I", "axis", ...
PMC10218459	CPP treatment was carried out indirectly by transferring 200 µL of the full medium into the wells of a 24-well plate and treating each well with CPP for 5 s, 10 s, and 20 s. Then, 100 µL of the treated medium was added to the cells in the 96-well plates, followed by the addition of 100 µL of warm complete medium contai...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679892	The quantity and quality of the obtained RNAs were determined using Nanodrop.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quantity", "and", "quality", "of", "the", "obtained", "RNAs", "were", ...
PMC9429973	Pathology and Tumor Biology, Kyoto University, Kyoto; Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo; Department of Technology Development, Kazusa DNA Research Institute, Chiba; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Backgr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	Hence, we chose the most representative sequences of SF to explore its antioxidant mechanism: one was an octapeptide GAGVGAGY from the region containing amorphous sequences, and the other was a dodecapeptide GAGSGAGAGSGA (labelled (GAGSGA)2) from the region with repetitive sequences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055443	Following the activation of innate immunity, B-cell mediated immune responses occur, and different antibodies from various isotypes are induced against V. cholerae LPS or other specific antigens such as cholera toxin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	According to the latest studies, secreted paracrine substances may mediate some of the therapeutic actions of MSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "latest", "st...
PMC11611077	Charge density α.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Charge", "density", "α", "." ] } ]
PMC11407042	We describe the steps for the preparation of the A549 cell line and P. aeruginosa strains, cell seeding, bacterial culture, infection, and cytotoxicity assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8623816	The quality and concentration of purified dsRNAs were detected by using electrophoresis on 1.0% agarose gels and stored at −80 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11794847	Because the tail vein engraftment method was unsuccessful in CMT-64 cells, LLC cell was used for the tail vein injection mouse model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens"...
PMC11761919	This limits the functional probiotics that reach the target intestinal sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "limits", "the", "functional", "probiotics", "that", "reach", "the", "target", ...
PMC11564405	In our study, we collected 140 patients with primary NSCLC to verify the RILPL2 expression and its prognostic value, the relationship between RILPL2 expression and CD4, CD8T cell infiltration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	Of all compounds shown in Table 2, the top four were selected as candidates for further investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "all", "compounds", "shown", "in"...
PMC11726848	Apoptosis is an immunogenic and tolerogenic type of cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptosis", "is", "an", "immunogenic", "and", "tolerogenic", "type", "of", "cell", "death", ...
PMC11574029	The CHIP assays revealed that NOTCH3 binds to the SPP1 promoter in T24 and 5637 cells, with more significant binding at Region1; however, this binding was absent in the negative control. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Thrombosis (VTE or arterial) in patients not started on alternative anticoagulant defined as thrombosis from sending HIT till 90 days after discharge or death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10547921	Jinliang Yang's team conjugated cryptophycin-55, a prodrug of cryptophycin-52 (CR55, which can be reincarnated into cryptophycin-52 under physiological conditions), with trastuzumab.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	We found that the DHPE-biotin signals were generally reduced in all subcellular regions following the methanol or acetone treatment (Fig. 1B and C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11772585	Data are shown as mean ± SEM. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "±", "SEM", ".", "*" ] } ]
PMC11297139	Surprisingly, ARID1A showed increased expression in Ewing’s sarcoma patient tissue resulting in visible nuclear foci, while normal bone tissue exhibited much lower punctate pattern throughout the nucleus (Fig. 3c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Co-variates significantly associated with MMR and MR in multi-variable analyses in the training dataset were used to develop a predictive scoring system based on standardized regression coefficients (beta [β]) and the model tested in the validation dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11781181	Recently, another programmed necrosis modality known as ferroptosis has been described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "another", "programmed", "necrosis", "modality", "known", "as", ...
PMC10758402	Once the tumors reached a volume of approximately 100 mm after 11 days, the mice received injections of HSV (1 x 10 pfu) directly intratumorally, either once, twice, thrice, or six times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	Such circRNAs are competitive endogenous RNAs (ceRNAs), mainly located in the cytoplasm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "circRNAs", "are", "competitive", "endogenous", "RNAs", ...
PMC11622247	We commenced our study by preparing DNA FIT probes (Fig. 2) targeting the CDR3 regions of T cell receptor (TCR) mRNA in the CCRF-CEM T cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720107	Our findings showed the health-promoting and anticancer properties of garlic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "showed", "the", "health-promoting", "and", "anticancer", "properties", "of", ...
PMC11615101	The graph showing fold change of IL-6 mRNA expression in different treated groups. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graph", "showing", "fold", "change", "of", "IL-6", "mRNA"...
PMC11190062	Increased BCL2 and BCL2L1 in response to TLR activation may make the MM cells less prone to apoptosis in general, but this was not explored in the current study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604830	This discrepancy may be attributable to the broader signal for this sample, which can be associated with the shorter T2 value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "disc...
PMC9454178	C Representative scanned images of GIST samples with low or high CDK7 protein expression, as determined by IHC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Representative", "scanned", ...
PMC11754094	Human T cells were isolated from the peripheral blood mononuclear cells (PBMCs) of two healthy donors (ASAN04 and ASAN-68) using a magnetic-activated cell sorting (MACS) system and then stimulated by anti-CD3/CD28 beads before introduction of Cas9-sgRNA ribonucleoprotein (RNP) complexes by electroporation (Fig. 2g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10652261	C NMR (75 MHz, DMSO-d6) δ (ppm): 42.92 (CH2), 44.32 (CH3), 46.29 (2CH2), 53.10 (2CH2), 61.76 (CH), 98.93 (C), 113.10 (2CH), 116.77 (2CH), 120.55 (CH), 125.75 (CH), 126.97 (2CH), 127.91 (C), 128.16 (CH), 133.74 (2CH), 134.53 (2C), 147.05 (C), 148.19 (C), 154.58 (C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Existing approaches to add clonal resolution to droplet-based single-cell RNAseq data use qualitative information available from calls of individual mitochondrial or genomic single nucleotide variants as well as copy number variants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	Fast overall fixation rate compared with protein–protein interaction dynamics decreases the fixation artifact. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fast", "overall", "fixation", "rate", "compared", "wit...
PMC11190238	EMT occurs in both physiological conditions such as gastrulation and wound healing and pathological conditions such as tissue fibrosis and cancer progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EMT", "occur...
PMC11773391	Therefore, we propose that inhibiting this chemoresistance mechanism can be achieved through the combination of chemotherapy and ERK inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", ...
PMC9429973	Median follow-up duration for TFR patients was 27 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow-up", "duration", "for", "TFR", "patients", "was", "27", "months", "." ] } ]
PMC11394730	As mentioned above, malignant cells supply their demand for glucose by overexpressing transporters such as GLUT1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "mentioned", "above", ",", "malignant", ...
PMC11591052	Here, we have demonstrated that 20E increased the expression of a number of enzymes that are involved in glycolysis and one-carbon metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ...
PMC9429973	M. D’Agostino, S. Bringhen, R. Ria, F. Ciceri, A. P. Falcone, M. Michieli, M. Grasso, F. Pane, M. Quaresima, F. Cattel, M. Mirabile, F. Fioritoni, M. T. Petrucci, V. Cotugno, A. Capra, S. Pezzatti, M. L. Mosca Siez, M. Cantonetti, G. Margiotta Casaluci, P. Bertazzoni, R. Floris, M. Offidani, G. Pietrantuono, A. Evangel...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Briefly, after 48 h of phenylalanine deprivation, MM cells (1 × 10 cells) were fixed with 70% ethanol overnight and then incubated with an RNase/PI staining solution for 30 to 60 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: A total of 133 patients were randomized with 68 receiving PLASMA with a median age of 68 years (range 36-95) or CONTROL (n=65, of which n=10 (15.4%) crossed over at day 10) with a median age of 70 years (range 38-90).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11285179	Abnormal differentiation of stromal cells is an essential characteristic of malignant tumors and is correlated with abnormal metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Abnormal", "differentiation", "of", "stromal...
PMC9910796	Samples were examined in a Jeol JEM-1010 electron or a Jeol 1400Flash microscope operating at 80 and 100 kV, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "were", ...
PMC9599726	Their observations are in line with our data which demonstrate that RSL3 induced ferroptosis through important lipid peroxidation in the imatinib-sensitive and -resistant human GIST cells, GIST882 cells, and GIST48 cells, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	CSF (drawn into tube with no fixative agent and processed within 2 hours) was concentrated by centrifugation and incubated with combination of antibodies (CD20/CD10/CD45/CD34/CD19/CD3/Syto41 in BCP ALL and CD4/CD99/CD5/CD3/CD7/CD16 + 56/CD8/CD45/Syto41 in T ALL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9386809	The synthesized complex solution was prepared in different concentrations viz.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "synthesized", "complex", "solution", "was", "prepared", "in", "different", "concentr...
PMC11767725	Dysbiosis amplifies inflammation through PRRs on keratinocytes, including TLRs (TLR2, TLR4) and NOD-like receptors, creating a feedback loop that sustains inflammation and further disrupts the microbiome .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936	Future studies aim to extend the time course examined following receptor repression and to overexpress the receptors to see if JNK activation increases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future"...
PMC11472639	We used cryopreserved cells, rather than fresh whole blood, because we sought to decide on an NK-cell panel after determining the results of plasma cell mobilisation and ADCC assay results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	Black bar equals 100 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Black", "bar", "equals", "100", "μm", "." ] } ]
PMC11088135	p < 0.01 vs. mimic control group MiR-376a-3p is a direct target of lncRNA NUTM2A-AS1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.01", "vs.", "mimic", "control", "group", ...
PMC11544122	FLAG-CXCR4, FLAG-AT1AR, FLAG- FLAG-B2AR, and FLAG-CXCR5 have been previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FLAG-CXCR4", ",", "FLAG-AT1AR", ",", "FLAG-", "FLAG-B2AR", ",", "and", ...
PMC11322866	The images were analyzed using Fiji ImageJ 2.1.0 software (National Institute of Health, Bethesda, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "images", "were", "analyzed...
PMC9351137	Using immunofluorescence microscopy (IFM), we investigated the subcellular localization of seven endogenous subunits of the SRCAP and p400/Tip60 chromatin remodeling complexes during cell division in fixed HeLa cells: CFDP1 (SRCAP complex), MRG15, p400 and Tip60 (p400/Tip60 complex), BAF53a, GAS41, and YL1 (both comple...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11186948	Acetylation assessment was carried out according to AlphaLISA Cellular Detection Kit protocols for Acetylated-Histone H3 Lysine 27 (H3K27ac) (AL720, PerkinElmer) and unmodified Histone H3 Lysine 4 (H3K4) (AL719, PerkinElmer), used for normalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	COVID-19-related 30-day mortality was reduced from 9% to 4% between series A and B. However, this difference was not significant on MVA (OR 0.36; CI95% 0.10-1.09; p=0.084).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352311	It can predict the targets of natural products or their components in diseases, construct interaction networks of these targets, and ultimately reveal the potential therapeutic mechanisms of natural products .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806818	The CEM aptamer “HS-sgc8c” was modified on the surface of the gold electrode by Au-S bonding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CEM", "aptamer", "“", "HS-sgc8c...
PMC11536589	Mechanismly, the β-catenin/Tcf4 complex played a crucial role in promoting the production of MGST1, which led to prevent ferroptosis in KRAS inhibitor-resistant PDAC in both in vitro and in vivo models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11462673	Employing short hairpin RNA (shRNA) techniques, we delineated the functional impact of LDB1 in T-ALL cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Employing", "short", "hairpi...
PMC8270637	Furthermore, we found that TGF-β1 upregulated the expression of PD-1 and CTLA-4 in a concentration-dependent manner ( Figure 1 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", ...
PMC11701801	Thus, SMARCA4/SMARCA2-deficient and SS18–SSX fusion cancer cells depend on the expression of KREMEN2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "SMARCA4/SMARCA2-deficient", "and", "SS18–SSX", "fusion", ...
PMC8524093	CHIKF is a complex disease resultant from the infection of a plethora of cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHIKF", "is", "a", "complex", "disease", "resultant", "from...
PMC11531744	Representative images of the wound healing assay. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "the", "wound", "healing", "assay", ".", "(" ] } ]
PMC11687167	Wu et al. showed that NFATc is the direct target of p38 MAPK and that its overall effect is significant .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wu", "et", "al.", "sho...
PMC9429973	At first interim restaging, five patients had an abscopal response (ARR 56%, 95%CI 16.9-74.9%) by central response assessment and 56% achieved a PR (ORR 56%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	The coordination geometry around the Co(III) center is described, by DFT methods, as a typical piano-stool structure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "coordination", "geome...
PMC10975211	A specific anticancer effect of a buforin IIb and anionic peptide (a derived magainin sequence) conjugate, bonded via a matrix metalloproteinase (MMP) cleavable linker, was obtained and investigated by Jang et al. (2011) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742290	Genetic polymorphisms and mutations in the LGR5 gene among individuals can alter the function of the LGR5 gene or its expression levels, leading to diverse biological outcomes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, significant outcome differences were observed among CR patients (76,3%), subdivided in those who achieved ALC in all TPs vs others.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11539788	The remaining cell extracts were precleared with 20 µl of Protein A/G magnetic beads for 4 h. After centrifugation at 4 °C for 10 min, the supernatants were transferred to a new tube and incubated with the target antibody or anti-rabbit IgG with gentle rotation at 4 °C overnight for protein pull-down.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	Considering that reductions of XPO1 protein levels can significantly influence its overall functionality, we propose that this mechanism may be implicated in the anti-myeloma effects of SEL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8567602	Anti-FLAG purification of SMARCD1 and associated CBAF subcomplexes from cells coexpressing SMARCB1 identified the position of the SMARCB1 band in SDS-PAGE gels, and revealed its loss when omitted from the expression system (Fig. 6E and F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	Then, an aqueous solution of KCN 4 N (3.00 mmol, 195 mg) in water (0.75 mL) was added dropwise, and the reaction mixture was left stirring for 16 h. After the completion of the reaction, CH2Cl2 (5 mL) was added and the organic layer was washed with brine (10 mL), dried over Na2SO4, and concentrated under reduced pressu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791432	The gender distribution showed the majority of patients were males, accounting for 57 % and 63 % of the two datasets, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7553912	Our initial hypothesis was therefore that OSM might inhibit kidney stone formation through decreases in M1 type of renal macrophages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "initial", "hypothesis...
PMC9398137	The level of MCL1 expression and MCL1 occupational status impact sensitivity to S63845 in DLBCL and Burkitt lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "level", "of", "MCL1", "expressi...
PMC6364197	no. A07751), CD8-PE (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "A07751", ")", ",", "CD8-PE", "(", "cat", "." ] } ]
PMC11786704	Masson's trichrome staining showed a significant increase in collagen fiber production in the PC capsule-treated group, suggesting its advantage in promoting wound reconstruction (Fig. 4G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	Suzuki coupling of indole 39 with 4,6-dimethylpyrimidyl boronic acid (40) affords compound 41, followed by indole N-alkylation with the sulfinate 42.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4112127	The cell lines were then either treated with 5 μM of the DNA methylation inhibitor 5-Aza-2’-deoxycytidine (5-Aza-dC) or mock treated with DMSO for 5 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10454535

The tubes were incubated in the dark for 15 min at room temperature on a benchtop shaker.

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PMC11363012

The cells were then collected in 96-well plates compatible with the autosampler of an UHPLC-HRMS system.

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PMC9429973

Subsequently, CEBPE takes over and directs sequential promotor-driven cell cycle exit by (i) launching a MYC – MAD switch leading to inhibition of G1/S gene expression, (ii) repression of E2F-meditated G2/M gene expression, and (iii) up-regulation of Cdk1/2/4inhibitors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11673128

In this work, we provided preclinical evidence supporting the efficacy of combining TKIs with anti-CD47 mAb in both blood and solid ALK-positive cancers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9727330

Hany Khalil designed the research plan, supervised overall research, provided and interpreted data and wrote the manuscript.

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PMC9712534

Subsequent studies have demonstrated that these missense mutations in the catalytic domain lead to a significant decrease in the catalytic activity of TOP2B.

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PMC11228511

Human lamin A formed a meshwork with uniform gaps of ~0.085 µm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "lamin", "A", "formed", "a", "meshwork", "with", "uniform", "gaps", ...

PMC11342785

Nearly identical results were observed using untagged constructs and DIC microscopy to visualize these droplets (Figs. 1C and S1A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nearly", "identical", ...

PMC11726183

We then performed the docking studies using the XP-docking protocol (extra precision) with all other default parameters.

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PMC10933092

The ceRNA network (Figure 8C) was constructed via Cytoscape 3.9.1, and included 15 lncRNAs (seven upregulated and eight downregulated; sh-TRMT61A 5637 cells vs. sh-NC 5637 cells), 8 mRNAs (four upregulated and four downregulated; sh-TRMT61A 5637 cells vs. sh-NC 5637 cells), and 118 miRNAs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7215832

Results: RX-3117 treatment decreased total DNA-cytosine-methylation in A549 non-small cell lung cancer (NSCLC) cells, and induced protein expression of MGMT, p16 and E-cadherin in A549 and SW1573 NSCLC cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11138140

A two-dimensional increase in surface area due to cell spreading is not indicative of a three-dimensional increase in cell volume.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "two-dimensional", "incr...

PMC11787651

The dashed line denotes a fold change of 2 in either direction, whereas the horizontal line indicates the significance threshold (p < 0.05).

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PMC11190238

Plasticity and fluidity of cell fate determination or EMT execution is thus dictated by the balance between different regulatory circuits governing the genome architecture, epigenetic modifications, transcription, translation, and post-translational modifications.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11727638

After leaving it to stand at 15 °C for 5 min, the Cell Domes formed on the glass plate were immersed in the medium containing 4000 U/mL catalase (from bovine liver; Fujifilm Wako Chemical).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The most common co-mutations were NPM1 (53%, 8/15), DNMT3A (27%, 4/15), IDH1 (20%, 3/15) and IDH2 (20%, 3/15).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9351137

Moreover, INO80, Pontin, Reptin, and Tip60 chromatin remodelers were shown to relocate to the mitotic apparatus and suggested to play direct roles in cell division in human cells [24–29].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11267036

Research has revealed that the STAT1/RIG-I axis plays a significant part in anti-tumor processes .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "has", "revealed", "that", "the", "STAT1/RIG-I", "axis", ...

PMC10218459

CPP treatment was carried out indirectly by transferring 200 µL of the full medium into the wells of a 24-well plate and treating each well with CPP for 5 s, 10 s, and 20 s. Then, 100 µL of the treated medium was added to the cells in the 96-well plates, followed by the addition of 100 µL of warm complete medium contai...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11679892

The quantity and quality of the obtained RNAs were determined using Nanodrop.

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PMC9429973

Pathology and Tumor Biology, Kyoto University, Kyoto; Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo; Department of Technology Development, Kazusa DNA Research Institute, Chiba; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Backgr...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11401358

Hence, we chose the most representative sequences of SF to explore its antioxidant mechanism: one was an octapeptide GAGVGAGY from the region containing amorphous sequences, and the other was a dodecapeptide GAGSGAGAGSGA (labelled (GAGSGA)2) from the region with repetitive sequences.

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PMC11055443

Following the activation of innate immunity, B-cell mediated immune responses occur, and different antibodies from various isotypes are induced against V. cholerae LPS or other specific antigens such as cholera toxin.

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PMC11519077

According to the latest studies, secreted paracrine substances may mediate some of the therapeutic actions of MSCs.

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PMC11611077

Charge density α.

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PMC11407042

We describe the steps for the preparation of the A549 cell line and P. aeruginosa strains, cell seeding, bacterial culture, infection, and cytotoxicity assay.

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PMC8623816

The quality and concentration of purified dsRNAs were detected by using electrophoresis on 1.0% agarose gels and stored at −80 °C.

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PMC11794847

Because the tail vein engraftment method was unsuccessful in CMT-64 cells, LLC cell was used for the tail vein injection mouse model.

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PMC11761919

This limits the functional probiotics that reach the target intestinal sites.

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PMC11564405

In our study, we collected 140 patients with primary NSCLC to verify the RILPL2 expression and its prognostic value, the relationship between RILPL2 expression and CD4, CD8T cell infiltration.

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PMC11594074

Of all compounds shown in Table 2, the top four were selected as candidates for further investigation.

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PMC11726848

Apoptosis is an immunogenic and tolerogenic type of cell death .

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PMC11574029

The CHIP assays revealed that NOTCH3 binds to the SPP1 promoter in T24 and 5637 cells, with more significant binding at Region1; however, this binding was absent in the negative control. (

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PMC9429973

Thrombosis (VTE or arterial) in patients not started on alternative anticoagulant defined as thrombosis from sending HIT till 90 days after discharge or death.

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PMC10547921

Jinliang Yang's team conjugated cryptophycin-55, a prodrug of cryptophycin-52 (CR55, which can be reincarnated into cryptophycin-52 under physiological conditions), with trastuzumab.

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PMC11786767

We found that the DHPE-biotin signals were generally reduced in all subcellular regions following the methanol or acetone treatment (Fig. 1B and C).

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PMC11772585

Data are shown as mean ± SEM. *

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PMC11297139

Surprisingly, ARID1A showed increased expression in Ewing’s sarcoma patient tissue resulting in visible nuclear foci, while normal bone tissue exhibited much lower punctate pattern throughout the nucleus (Fig. 3c).

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PMC9429973

Co-variates significantly associated with MMR and MR in multi-variable analyses in the training dataset were used to develop a predictive scoring system based on standardized regression coefficients (beta [β]) and the model tested in the validation dataset.

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PMC11781181

Recently, another programmed necrosis modality known as ferroptosis has been described.

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PMC10758402

Once the tumors reached a volume of approximately 100 mm after 11 days, the mice received injections of HSV (1 x 10 pfu) directly intratumorally, either once, twice, thrice, or six times.

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PMC10565698

Such circRNAs are competitive endogenous RNAs (ceRNAs), mainly located in the cytoplasm.

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PMC11622247

We commenced our study by preparing DNA FIT probes (Fig. 2) targeting the CDR3 regions of T cell receptor (TCR) mRNA in the CCRF-CEM T cell line.

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PMC11720107

Our findings showed the health-promoting and anticancer properties of garlic.

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PMC11615101

The graph showing fold change of IL-6 mRNA expression in different treated groups. (

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PMC11190062

Increased BCL2 and BCL2L1 in response to TLR activation may make the MM cells less prone to apoptosis in general, but this was not explored in the current study.

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PMC11604830

This discrepancy may be attributable to the broader signal for this sample, which can be associated with the shorter T2 value.

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PMC9454178

C Representative scanned images of GIST samples with low or high CDK7 protein expression, as determined by IHC.

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PMC11754094

Human T cells were isolated from the peripheral blood mononuclear cells (PBMCs) of two healthy donors (ASAN04 and ASAN-68) using a magnetic-activated cell sorting (MACS) system and then stimulated by anti-CD3/CD28 beads before introduction of Cas9-sgRNA ribonucleoprotein (RNP) complexes by electroporation (Fig. 2g).

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PMC10652261

C NMR (75 MHz, DMSO-d6) δ (ppm): 42.92 (CH2), 44.32 (CH3), 46.29 (2CH2), 53.10 (2CH2), 61.76 (CH), 98.93 (C), 113.10 (2CH), 116.77 (2CH), 120.55 (CH), 125.75 (CH), 126.97 (2CH), 127.91 (C), 128.16 (CH), 133.74 (2CH), 134.53 (2C), 147.05 (C), 148.19 (C), 154.58 (C).

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PMC9429973

Existing approaches to add clonal resolution to droplet-based single-cell RNAseq data use qualitative information available from calls of individual mitochondrial or genomic single nucleotide variants as well as copy number variants.

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PMC9817179

Fast overall fixation rate compared with protein–protein interaction dynamics decreases the fixation artifact. (

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PMC11190238

EMT occurs in both physiological conditions such as gastrulation and wound healing and pathological conditions such as tissue fibrosis and cancer progression.

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PMC11773391

Therefore, we propose that inhibiting this chemoresistance mechanism can be achieved through the combination of chemotherapy and ERK inhibitors.

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PMC9429973

Median follow-up duration for TFR patients was 27 months.

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PMC11394730

As mentioned above, malignant cells supply their demand for glucose by overexpressing transporters such as GLUT1 .

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PMC11591052

Here, we have demonstrated that 20E increased the expression of a number of enzymes that are involved in glycolysis and one-carbon metabolism.

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PMC9429973

M. D’Agostino, S. Bringhen, R. Ria, F. Ciceri, A. P. Falcone, M. Michieli, M. Grasso, F. Pane, M. Quaresima, F. Cattel, M. Mirabile, F. Fioritoni, M. T. Petrucci, V. Cotugno, A. Capra, S. Pezzatti, M. L. Mosca Siez, M. Cantonetti, G. Margiotta Casaluci, P. Bertazzoni, R. Floris, M. Offidani, G. Pietrantuono, A. Evangel...

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PMC11365427

Briefly, after 48 h of phenylalanine deprivation, MM cells (1 × 10 cells) were fixed with 70% ethanol overnight and then incubated with an RNase/PI staining solution for 30 to 60 min.

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PMC9429973

Results: A total of 133 patients were randomized with 68 receiving PLASMA with a median age of 68 years (range 36-95) or CONTROL (n=65, of which n=10 (15.4%) crossed over at day 10) with a median age of 70 years (range 38-90).

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PMC11285179

Abnormal differentiation of stromal cells is an essential characteristic of malignant tumors and is correlated with abnormal metabolism.

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PMC9910796

Samples were examined in a Jeol JEM-1010 electron or a Jeol 1400Flash microscope operating at 80 and 100 kV, respectively.

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PMC9599726

Their observations are in line with our data which demonstrate that RSL3 induced ferroptosis through important lipid peroxidation in the imatinib-sensitive and -resistant human GIST cells, GIST882 cells, and GIST48 cells, respectively.

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PMC9429973

CSF (drawn into tube with no fixative agent and processed within 2 hours) was concentrated by centrifugation and incubated with combination of antibodies (CD20/CD10/CD45/CD34/CD19/CD3/Syto41 in BCP ALL and CD4/CD99/CD5/CD3/CD7/CD16 + 56/CD8/CD45/Syto41 in T ALL).

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PMC9386809

The synthesized complex solution was prepared in different concentrations viz.,

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PMC11767725

Dysbiosis amplifies inflammation through PRRs on keratinocytes, including TLRs (TLR2, TLR4) and NOD-like receptors, creating a feedback loop that sustains inflammation and further disrupts the microbiome .

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PMC2777936

Future studies aim to extend the time course examined following receptor repression and to overexpress the receptors to see if JNK activation increases.

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PMC11472639

We used cryopreserved cells, rather than fresh whole blood, because we sought to decide on an NK-cell panel after determining the results of plasma cell mobilisation and ADCC assay results.

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PMC10114490

Black bar equals 100 μm.

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PMC11088135

p < 0.01 vs. mimic control group MiR-376a-3p is a direct target of lncRNA NUTM2A-AS1.

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PMC11544122

FLAG-CXCR4, FLAG-AT1AR, FLAG- FLAG-B2AR, and FLAG-CXCR5 have been previously described.

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PMC11322866

The images were analyzed using Fiji ImageJ 2.1.0 software (National Institute of Health, Bethesda, USA).

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PMC9351137

Using immunofluorescence microscopy (IFM), we investigated the subcellular localization of seven endogenous subunits of the SRCAP and p400/Tip60 chromatin remodeling complexes during cell division in fixed HeLa cells: CFDP1 (SRCAP complex), MRG15, p400 and Tip60 (p400/Tip60 complex), BAF53a, GAS41, and YL1 (both comple...

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PMC11186948

Acetylation assessment was carried out according to AlphaLISA Cellular Detection Kit protocols for Acetylated-Histone H3 Lysine 27 (H3K27ac) (AL720, PerkinElmer) and unmodified Histone H3 Lysine 4 (H3K4) (AL719, PerkinElmer), used for normalization.

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PMC9429973

COVID-19-related 30-day mortality was reduced from 9% to 4% between series A and B. However, this difference was not significant on MVA (OR 0.36; CI95% 0.10-1.09; p=0.084).

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PMC11352311

It can predict the targets of natural products or their components in diseases, construct interaction networks of these targets, and ultimately reveal the potential therapeutic mechanisms of natural products .

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PMC11806818

The CEM aptamer “HS-sgc8c” was modified on the surface of the gold electrode by Au-S bonding.

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PMC11536589

Mechanismly, the β-catenin/Tcf4 complex played a crucial role in promoting the production of MGST1, which led to prevent ferroptosis in KRAS inhibitor-resistant PDAC in both in vitro and in vivo models.

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PMC11462673

Employing short hairpin RNA (shRNA) techniques, we delineated the functional impact of LDB1 in T-ALL cell lines.

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PMC8270637

Furthermore, we found that TGF-β1 upregulated the expression of PD-1 and CTLA-4 in a concentration-dependent manner ( Figure 1 ).

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PMC11701801

Thus, SMARCA4/SMARCA2-deficient and SS18–SSX fusion cancer cells depend on the expression of KREMEN2.

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PMC8524093

CHIKF is a complex disease resultant from the infection of a plethora of cell types.

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PMC11531744

Representative images of the wound healing assay. (

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PMC11687167

Wu et al. showed that NFATc is the direct target of p38 MAPK and that its overall effect is significant .

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PMC9429973

At first interim restaging, five patients had an abscopal response (ARR 56%, 95%CI 16.9-74.9%) by central response assessment and 56% achieved a PR (ORR 56%).

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PMC10988555

The coordination geometry around the Co(III) center is described, by DFT methods, as a typical piano-stool structure.

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PMC10975211

A specific anticancer effect of a buforin IIb and anionic peptide (a derived magainin sequence) conjugate, bonded via a matrix metalloproteinase (MMP) cleavable linker, was obtained and investigated by Jang et al. (2011) .

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PMC11742290

Genetic polymorphisms and mutations in the LGR5 gene among individuals can alter the function of the LGR5 gene or its expression levels, leading to diverse biological outcomes .

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PMC9429973

However, significant outcome differences were observed among CR patients (76,3%), subdivided in those who achieved ALC in all TPs vs others.

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PMC11539788

The remaining cell extracts were precleared with 20 µl of Protein A/G magnetic beads for 4 h. After centrifugation at 4 °C for 10 min, the supernatants were transferred to a new tube and incubated with the target antibody or anti-rabbit IgG with gentle rotation at 4 °C overnight for protein pull-down.

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PMC11731161

Considering that reductions of XPO1 protein levels can significantly influence its overall functionality, we propose that this mechanism may be implicated in the anti-myeloma effects of SEL.

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PMC8567602

Anti-FLAG purification of SMARCD1 and associated CBAF subcomplexes from cells coexpressing SMARCB1 identified the position of the SMARCB1 band in SDS-PAGE gels, and revealed its loss when omitted from the expression system (Fig. 6E and F).

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PMC11696576

Then, an aqueous solution of KCN 4 N (3.00 mmol, 195 mg) in water (0.75 mL) was added dropwise, and the reaction mixture was left stirring for 16 h. After the completion of the reaction, CH2Cl2 (5 mL) was added and the organic layer was washed with brine (10 mL), dried over Na2SO4, and concentrated under reduced pressu...

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PMC11791432

The gender distribution showed the majority of patients were males, accounting for 57 % and 63 % of the two datasets, respectively.

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PMC7553912

Our initial hypothesis was therefore that OSM might inhibit kidney stone formation through decreases in M1 type of renal macrophages.

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PMC9398137

The level of MCL1 expression and MCL1 occupational status impact sensitivity to S63845 in DLBCL and Burkitt lymphoma.

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PMC6364197

no. A07751), CD8-PE (cat.

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PMC11786704

Masson's trichrome staining showed a significant increase in collagen fiber production in the PC capsule-treated group, suggesting its advantage in promoting wound reconstruction (Fig. 4G).

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PMC11345828

Suzuki coupling of indole 39 with 4,6-dimethylpyrimidyl boronic acid (40) affords compound 41, followed by indole N-alkylation with the sulfinate 42.

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PMC4112127

The cell lines were then either treated with 5 μM of the DNA methylation inhibitor 5-Aza-2’-deoxycytidine (5-Aza-dC) or mock treated with DMSO for 5 days.

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