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OTAR3088
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BioData-CellLine_annotated

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PMC11574029
After 24 h of incubation at 37 °C, chambers were washed with PBS and fixed with 4% paraformaldehyde for about 30 min.
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PMC6268318
The data were updated in April 2011, using biological activity of the Combretum species as search term.
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PMC9841531
MCT1 inhibition prevents lactate and pyruvate influx into aerobic cells, which forces the cells to use glucose for energy supply.
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PMC11746948
We further verified this interaction via co-immunoprecipitation and immunostaining assays (Fig. 5b, c).
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PMC9398137
We downregulated MCL1 (shMCL1) in U2932 cell line having high baseline MCL1 expression and overexpressed the MCL1 (MCL1) in HBL-1 cell line having low baseline MCL1 expression.
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PMC11703992
If an SNP contained eQTL information for more than one gene, the causal effect on the disease might be driven by different genes, and the colocalization analysis was further adopted to identify the shared or distinct genetic variants of GCA and eQTLs.
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PMC10999934
The significance of biosynthetic pathways in the development of chemoresistance is readily apparent.
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PMC10890055
The temperature of the cooling medium was maintained between 30 and 50 °C.
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PMC2777936
NT2/D1 cells were individually infected with lentiviral shRNAs for FZD5, FZD7, or a control shRNA.
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PMC11435360
CD4 cells were reduced in the BBN PAG group (p < 0.05) but preserved in all other BBN groups compared to the BBN saline group (Figure 4I).
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PMC8143558
Saponins are identified by their ability to rupture erythrocytes or form colloidal solutions that can produce a stable lather when they are shaken in the presence of water .
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PMC11791478
Following another wash, horseradish peroxidase substrate (SuperSignal ELISA Pico Chemiluminescent substrate, Thermo Fisher Scientific) was added, and luminescence was measured using a plate reader spectrophotometer.
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PMC11087766
P. aeruginosa strain PA01 K2733 cells expressing the indicated sfGFP-tagged PhiPA3 nuclear protein infected with either PhiPA3 or PhiKZ.
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PMC5308810
Cells (5x10) were cultured to >80% confluency in 12-well plates.
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PMC10538569
RLU in HIV-1 pseudotyped AD8, Bru-3, Yu2, CNE3, CNE11, Con B, Con C or JRFL-captured iDCs alone were included for the comparison. (
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PMC10114490
Fig. 5Robust induction of the hepatocyte program in iHDF-T. iHDF-T maintain inducibility after more than 80 population doubling without losing hepatic phenotype in diHLC-T. A Volcano plot of all genes expressed in PD and PD diHLC-T (three replicates each) by RNAseq.
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PMC11515150
no significance). (
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PMC11697065
Stable pools and clonal cell lines were collected by centrifugation, fixed in 70 % methanol, and stored at −20 °C before further processing.
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PMC9681981
Bacterial contact with the Caco-2 cells induces a significant effect on the mean expression of the ε-toxin gene (etx) (P<0.05).
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PMC2363604
In contrast the ECM from HUVEC cells contained large amounts of CD55 despite expressing low levels of CD55 on their cell surface.
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PMC9429973
A final analysis of the effect of neonatal screening for SCD will follow after completion of data collection in all participating centers in the Netherlands.
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PMC10114490
Cell viability was determined by propidium iodide exclusion in the main object.
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PMC9220170
In addition, the important role of SELENOT in brain ontogenesis has been repeatedly shown: for example, a knockout line of mice in which SELENOT was specifically destroyed in nerve cells was characterized by a decrease in the volumes of various brain structures .
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PMC9429973
Impact on ED was higher in MF as compared to PV and ET.
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PMC11127909
The fluorescence of the cytosolic dye was quenched by adding 1 mM CoCl2 (Macklin; #C804815) and incubating at 37 °C for another 30 min.
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PMC11755624
These findings suggest that the molecule could be involved in the pathogenesis of psoriasis.
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PMC7709199
The conditioned medium was harvested five days post-transfection, centrifuged for 10 min at 6000g and filtered through a 0.22 µm filter.
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PMC10006224
Co-depletion of NIPBL and CTCF further reduced the presence of cohesin-STAG2 genome-wide while cohesin-STAG1 was maintained at CTCF sites (Supplementary Fig. 5c–e).Fig.
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PMC11655498
The expression of EBV lytic genes determines the progression of a lytic cycle (Figure 2A and Table 2).
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PMC11594806
Sarcomas are highly diverse tumors, leading to various mechanisms of drug resistance.
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PMC9635307
NheI and NotI restriction sites were generated at the 5′ and 3′ ends, respectively, of the Ceacam1-2L cDNA (kindly provided by Dr. Nicole Beauchemin, McGill University, Montreal, Canada), by PCR utilizing the following primers: 5′CTAGCTAGCTAGGAGACATGGAGCTGGC3′ and 5′ATAGTTTAGCGGCCGCTCACTTCTTTTTTACTTCT3’.
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PMC3122064
Therefore, it is tempting to speculate that the Nutlin-3-induced release of the negative feedback on p53 by MDM2 further shifts the balance towards transcribing pro-apoptotic genes, for instance involved in the Fas death receptor pathway.
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PMC6650823
Such a design strategy is opening a promising avenue to develop multi-targeting hybrid systems as new delivery tools with superior therapeutic effects for glioma treatment .
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PMC9926039
It is also reported that high expression of TLR4 in lung cancer tissues had a meaningful relationship with the malignancy of lung cancer.
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PMC11730305
The FT-IR for Ellagic acid shows absorption peaks in 500 to 1300 cm due to C-O, C-H, and C = O bonds, respectively.
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PMC11754784
All human blood analyzed in this study were collected with informed consent from a healthy volunteer (female, 28-year-old) and approved protocols that complied with all relevant ethical regulations at Renji Hospital, School of Medicine, Shanghai Jiao Tong University.
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PMC11768927
These data suggest that optimizing the use of chemotherapeutic drugs in combination with VSV may be strain/mutation-dependent.
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PMC10040136
Created with BioRender.com Proposed model of MSC-induced GIST resistance.
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PMC10957991
Z1 inverted microscope and Zeiss Plan Apo 10x/0.45, WD 2 mm (Air) objective.
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PMC9429973
W. Luo, C. Li, M. Du, F. Zhou, Y. Zhang, L. Tang, J. Wu, H. Jiang, Q. Wei, C. Lu, H. Kou, H. Mei, Y. Hu Institute of Hematology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease; Department of Pediatrics, Wu...
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PMC11713609
P-values were calculated using unpaired, two-tailed Student's t-test.
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PMC11697703
Sections were mounted using Vectashield with DAPI.
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PMC6114978
Protein of interest and Ponceau S loading control values were acquired, densities were inverted and background values were subtracted.
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PMC11739484
Moreover, current therapeutic strategies, including broad-spectrum MMP inhibitors like marimastat and selective inhibitors targeting specific MMPs, have shown limited success in clinical trials due to issues such as lack of specificity, off-target effects, and toxicity.
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PMC11472569
The intercellular transfer of ABCB1 via EVs has been supported by extensive experimental evidence.
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PMC10936243
It’s not donated; it’s purchased, because we need more regular supplies.
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PMC9429973
Of patients 18–40 years, 36.7%, 30.6%, and 16.3% experienced ≥1 treatment-related, RBC transfusion,or ICT complication, respectively, compared with 58.6%, 48.7%, and 28.3% of those >40 years.
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PMC11240052
Correlation expression of circ-0008285 between tissues and cell lines (R= 0.43, P<0.001)).
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PMC9429973
CAR-T cells had expanded in all patients, with no increase in the levels of IL-6, IL-8 and IFN-r in peripheral blood in 2 weeks after infusion.
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PMC11354239
In fact, the mechanism of response to rituximab is complex.
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PMC11672617
In our research, we have presented a study of the ROS ions level when investigating the effect of hybrid molecules and ionic compounds to gain a deeper understanding of the processes occurring in the mitochondria of Jurkat cells, including the processes of oxidation and phosphorylation on mitochondrial membranes (Figur...
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PMC11519583
The fluorescence in situ hybridization was conducted using the QuantGene ViewRNA in situ hybridization cell kit (Affymetric, Santa Clara) with an Ror2 mRNA probe designed by Affymetrics for hybridization to mouse Ror2 mRNA, in accordance with the manufacturer’s instructions.
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PMC9325715
UV–ViS study of Fe-bLTF complexes: (A) spectra of native bLTF and Fe-bLTF complexes; (B) the solutions of Fe-bLTF complex on the right and unmodified bLTF on the left; (C) spectra of Fe-bLTF complexes after Fe desorption in phosphate buffer pH 6.8 and 0.1 M hydrochloric acid; (D) Fe-bLTF complex solutions after 2 h des...
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PMC10743717
it was continuously covered by the related journals not making the necessary corrections.
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PMC9739791
The cytotoxicity of the Pt(IV) prodrug 28 was evaluated on malignant cell lines HeLa and MCF-7, and on normal lung epithelial cell line HPL1D (Table 9).
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PMC8864075
TWIST1 promotes EMT and metastasis through serine phosphorylation of p38, c-Jun N-terminal kinase (JNK), and Erk1/2 (Jun et al., 2011).
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PMC8973085
Found: C, 65.43; H, 5.09; N, 8.79.
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PMC9096373
All patients were divided into 2 groups based on whether they were above or below the cut-off value.
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PMC9429973
In BOOSTER samples, MMR patients retained significantly lower anti-spike-IgG-Abs levels compared to MMD patients.
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PMC9596868
Interestingly, we observed that quercetin shows best synergism with DNA damaging chemotherapeutic agents.
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PMC11530949
Using a Shimadzu-UV 1800 UV-Vis spectrometer and distilled water as a reference, the absorption spectra of the synthesized sample (Ag-doped CuO NPs) were obtained in the region of 200-800 nm (33, 34).
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PMC9220170
Next, using a plate reader, the optical density of solutions was measured in each test well at OD = 570 nm and background values at OD = 670 nm.
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PMC9429973
Aims: To characterize the active chromatin regulatory landscape of 4 major stereotyped subsets as compared to IGHV status-matched non-stereotyped CLLs.
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PMC9429973
This result confirmed the decreased suppressive ability of Tregs in absence of the two transcription factors, explaining the observed delay in CLL progression in cKO mice.
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PMC11704834
In the last decade, while significant effort has been made to determine the cell death pathways and apoptotic effectors impacted by EGFR-TKIs, knowledge on the transcriptional and epigenetic machineries downstream of EGFR remains limited.
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PMC9429973
Methods: A total of 38 children, adolescents and young adults with the diagnosis of ALL were included in the study.
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PMC9684669
Unfortunately, terfenadine has been linked to cardiac death in at least 125 and 14 cases in the United States and United Kingdom, respectively (55), and the Food and Drug Administration (FDA) recommended its removal from the market in 1997 due to its pro-arrhythmic risk for long QT-related Torsades de Pointes (TdPs) (5...
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PMC9429973
We used the following search terms: liver, cirrhosis, and lymphoma.
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PMC11670407
Therefore, exploring new targets to reverse chemotherapy resistance to improve the prognosis of OS patients is important.
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PMC11759543
Pretreatment with Ac-LEHD-CMK slightly reversed the cleavage of caspase 9 but didn't reverse the cleavage of caspase 3 and PARP proteins and didn't affect the phosphorylation of H2AX in both cell lines (Fig. 6B).
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PMC11545737
Disruption of BBB was found to be dependent on activation of non-canonical inflammasome and not on TLR4 cytokines induction, although the LBP-CD14-TLR4 axis is necessary for LPS internalization.
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PMC11785489
We have shown this with respect to endogenous TCR sequences recognizing a self-antigen (MART-1) and engineered TCR sequences recognizing a viral antigen (pp65).
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PMC11740573
Anti-microbial treatment combined with anti-inflammatory therapy could be useful in the treatment of this condition.
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PMC11658074
Compared with those in the UVB group, histological analysis via HE, Masson, Sirius Red, SA-β-gal, and in situ dihydroethidium red fluorescence staining (Fig. 2f) revealed that the AT-EV group had a thinner epidermis, a thicker dermis, increased collagen levels, fewer senescent cells, and lower ROS levels (Fig. 2g-k).
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PMC11461874
Data are presented as mean ± SEM (n = 4) by setting the mean of control cells to 1.
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PMC4485786
On day 7, the cytokines were removed and the cells were trypsinized, counted, and reseeded at 2 × 10 cells/9.6 cm.
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PMC9429973
Of whom, 774 (0.2%) had a comorbid arterial embolism.
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PMC11441402
If the automated imaging system described in this paper is to be utilized more frequently in research, validation against other methods will be valuable.
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PMC11638255
Coring sites were chosen at random with areas exhibiting necrosis excluded prior by an experienced histopathologist using a hematoxylin-eosin stain.
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PMC11747949
We also analyzed CXCL8 receptors' CXCR1 and CXCR2 changes on 143B cells and PBMCs when they were grown as mono‐culture or in coculture.
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PMC9429973
A. Le Floch, K. Nagashima, D. Birchard, H. Pan, C. Korgaonkar, T. Norton, L. Perlee, A. Murphy, M. Sleeman, J. Orengo Inflammation and Immune Diseases; Regeneron, Tarrytown, United States of America Background: The common γ chain cytokine receptor (γc; IL2RG) family of cytokines includes interleukin 2 (IL2), IL4, IL7, ...
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PMC9436459
Gu et al. demonstrated that sanggenon C (130) exerted direct cytoprotective effects against hypoxia injury in cardiac cells via signaling mechanisms involving the activation of AMPK and concomitant inhibition of target of rapamycin (mTOR) and forkhead box O3a (FOXO3a) .
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PMC9429973
Moreover, patients were analyzed for complete blood count, BCR-ABL1 in peripheral blood by RQ-PCR and bone marrow examination.
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PMC11089031
The fluorescence signal was collected at 72 ℃ at temperature cycles stage and consecutive collected at melting curve stage.
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PMC9429973
Although leading to an initial response, especially in pts with skin-only GVHD, studies have suggested that it may not be an effective option since it does not prolong OS (5.5 months) and it is associated with high mortality rates due to infection.
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PMC11025866
Alternatively, inhibitors of EBV lytic reactivation may up- or down-regulate cellular genes that establish a repressive environment in the cells.
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PMC11515150
After overnight coculture with target cells at different E: T ratios, relative to spontaneous cytotoxicity of NT-NK cells, 12 C CAR-NK cells exerted specific recognition and remarkable elimination against multiple CD5 malignant cells even though the proportion of CD5 positivity on Jeko-1 cells was about 55% (Fig. 4a, F...
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PMC9118379
Because the examinations at the PSM level greatly affect the ultimate outcomes of verification, researchers can select performing specific examinations or adopting a “voting” strategy to determine reliable variant PSMs as passing at least k (say, k = 2 or 3) out of five examinations depending on their stringency requir...
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PMC10988555
H NMR [(CD3)2CO, Me4Si, 400.13 MHz] δ/ppm: 10.08 [d, 1, H1]; 9.58 [d, 1, H10]; 8.99 [d, 1, H3, JHH = 8.33 Hz]; 8.35 [d, 1, H8, JHH = 8.23 Hz]; 8.07 [m, 1, H2]; 7.80 [m, 1, H9]; 7.57 [m, 3, Hpara(PPh3)]; 7.40 [m, 6, Hmeta(PPh3)]; 7.18 [m, 6, Hortho(PPh3)]; 7.02 [s, 1, H6]; 6.68 [s, 5, HCp]; 6.50 [s, 2, H13].
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PMC11751675
Thus, many SLs exert multifaceted biological activities including anti-microbial, anti-fungal, anti-viral, anxiolytic, anti-tumor, anti-malarial, anti-trypanosomal, anti-diabetic, analgesic, and anti-inflammatory activities, as well as fragrances in the cosmetic industry.
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PMC11144382
NFIX proteins are predominantly located within the nucleus as determined by the overlap of the signal (teal colour) from the green fluorescent Flag tag on the NFIX protein and the blue DAPI stained nuclei.
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PMC9352806
In our study, the saponin content in the stocking solution dissolved by ethanol was 54.60 μg/mL ginsenoside Rg1 equivalent detected by vanillin–acetic acid method (Lin et al., 2020).
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PMC11271278
We used WGS data from primary human tumors in PCAWG to support our conclusions about the presence of complex rearrangements involving multiple oncogenes but the functional validation of enhancer hijacking in primary human tumors requires further development of 3D genomics assays and analysis methods that account for th...
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PMC11721096
Furthermore, the CHO@hTYR can be reused up to five times, as illustrated in the Supplementary Data (Figure S5).
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PMC9429973
Aims: To determine incidence of VTE after MBL/CLL diagnosis and compare it to age- and sex-matched VTE incidence in the general population.
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PMC9429973
The OS was not reached and PFS was 13 months [median follow-up time 22 months (0-157)] and this results was similar in the patient aged <70 and ≥70 years (OS not reached in both groups, PFS was 12 and 13 months in patient aged <70 years and ≥70 years, respectively) Summary/Conclusion: Real-life studies evaluating elder...
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PMC9429973
We found a strong correlation between CNS involvement (at the time of disease onset or in relapse/progression) and having ITI score at least 1 point (from 1 to 4), (p=0,008).
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PMC11548041
The aptamer-functionalized MNVs can thus be utilized as vehicles to deliver therapeutic cargo in an EpCAM-targeted fashion.
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PMC11695623
The absorbance at 450 nm was measured.
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PMC11745823
However, the survival period of patients who have glioma, especially GBM, has not been significantly prolonged.
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