PMCID string | Sentences string | ner list |
|---|---|---|
PMC5716223 | Nonetheless, we and others demonstrated that the transient NFκB activation plays a role during L6C5 and C2C12 “in vitro” differentiation , or during growth factors-promoted survival and/or differentiation of myogenic cells . | [
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PMC9429973 | The mean disease duration was 4.0 (4.5) years, and the mean length of follow-up was 2.8 (1.4) years. | [
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PMC11700165 | However, the linker-B region is 40 amino acids shorter in ITK-SYK. | [
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PMC11082662 | Considering the stimulation of carcinoma cell metabolism by ATP consumption (21) and the ability of SMPDL3B to hydrolyze ATP in promoting the proliferation of carcinoma cells, we believe this may constitute another crucial mechanism through which SMPDL3B promotes the emergence and progression of ovarian carcinoma. | [
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PMC11740508 | Primer sequences are shown in the following chart. | [
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PMC11676670 | We believe that our cell line represents the HGSOC subtype, which is known for widespread genomic alterations marked by prominent copy number changes, and we showed that 42% of the genome is affected in OVAR79. | [
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PMC9895440 | Trest displayed highest expression of clusters 4 and 6, which include the transcripts TNF and IL7R. | [
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PMC11789597 | Untargeted metabolomics analysis was also performed to further determine the impact of CAV1 inhibition on cell metabolism. | [
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PMC11802929 | For quantitative comparison of peptides in Fig. 2, we calculated the average value for each property for anchor residues and TCR-exposing residues. | [
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PMC8956657 | A cartoon representation is shown below highlighting the hydrogen bonds (see Supplementary Table 12 for a full list of hydrogen bond interactions). | [
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PMC11180402 | K-L) The invasion abilities of 5637 (vector) and 5637 (miR-129 Inhibitor) cells, with or without ISO treatment, were assessed using the Transwell assay (K), and the relative invasion ability was plotted in (L). ( | [
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PMC11269933 | T337 (corresponding to HmPKM2 T328) plays a crucial role in the formation of the hydrogen-bonding network and activation of water molecules, thus playing an important role in the protonation of the enol pyruvate’s ethylene carbon atom. | [
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PMC11392912 | All groups except HC were given a collagen dose of 1 µg/g of the body weight of the rat and also miRNA 1ng/gm of the body weight of the rat . | [
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PMC11481779 | Applying those variants to the reference creates a personalised genome of an individual. | [
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PMC11707577 | Accordingly, the interest in 3D cellular models has raised in recent years, highlighting diverse responses to PDT between 2D and 3D cell models. | [
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PMC11629143 | p < 0.05, **p < 0.01, ***p < 0.001, n.s. | [
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PMC9429973 | Therefore, approximately 30% of patients still require blood transfusion. | [
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PMC2118063 | It is expressed constitutively in macrophages, B cells, and some DCs and at low levels in resting T cells and granulocytes. | [
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PMC9429973 | Image: Summary/Conclusion: Collectively, our presented study accurately distinguished leukemic cells from normal T cells in T-ALL at a single-cell resolution. | [
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PMC11297139 | In vitro droplet-formation assay was performed as previously described. | [
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PMC11803918 | Quantification results of ROS generation in A375 cells after different treatments with or without light irradiation, measured by flow cytometry (n = 4, Xe lamp, 650 nm, 6.4 mW/cm, 12 min). ( | [
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PMC9429973 | T-cell engraftment followed from week 4 to 6. | [
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PMC11413393 | Samples were loaded into a Bio-Rad CFX96 real-time PCR detection system following the manufacturer’s protocol. | [
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PMC11585254 | Adjusted P values are shown. | [
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PMC11402217 | Immunohistochemistry of tibial and pulmonary OS samples showed marked DKK1 suppression in the XD23-treated group compared to the Model groups (Figures 6D and 6E), while β-catenin levels were sustained in the Model and high-dose XD23 groups (Figures 6D and 6F). | [
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PMC11075223 | In order to make Cimicifugae Rhizoma play a better role in clinic, different original plants should be distinguished in terms of plant traits, types and contents of components, pharmacological activities as well as genes . | [
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PMC11715644 | Hoechst 33 258 (1 : 50; Thermo Fisher), the primary antibody of P120 (1 : 600, (D7S2M) XP; Cell Signaling Tech., | [
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PMC11240052 | Bioinformatics (Target scan, circ intractome) and luciferase reporter analyses were used to predict target genes. | [
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PMC9429973 | HCL pts have outcomes that are comparable to those in the published literature. | [
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PMC11615743 | For the L‐DNA system, L‐DNA containing Sgc8‐T1 (500 nM) and TC01‐T2 (500 nM) (and Sgc4f‐S‐T3 for the triple aptamer‐based logic device) was first incubated with 5 × 10 CCRF‐CEM (or Ramos, K562, Jurkat) cells for 30 min at 4 °C in 100 µL of binding buffer. | [
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PMC10114490 | Mitochondrial membrane potential and reactive oxygen alteration was equivalent in most concentrations except at the lowest compound concentration, 1 µM, where PD was more sensitive. | [
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PMC11743975 | We then measured the ATP levels in these cells treated with different concentrations of niclosamide at different incubation times. | [
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PMC11300085 | More importantly, RhoA/ROCK1-EMT-mediated SK-OV-3 cell invasion is orchestrated by CMKLR1 upregulation after chemerin treatment (50 ng/mL). | [
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PMC11774747 | The durability of responses varied, with some patients achieving long-term remission. | [
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PMC11472569 | Ifergan et al. suggest that mitoxantrone resistance may result from its entrapment within the vesicular lumen of EVs mediated by overexpressed ABCG2 on the EV membrane. | [
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PMC10957991 | Immunofluorescence stainings were performed to detect morphology of the cells within the cultures. | [
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PMC9429973 | Since metformin is an FDA-approved drug, we assessed the metformin-induced apoptosis, in combination with AraC or VEN in 64 primary AML samples ex vivo. | [
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PMC11271800 | About 14% of GIST patients initially develop resistance to imatinib, and about 50% develop resistance after 2 years of treatment. | [
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PMC5600151 | The treatment of these animals with these multifunctional nanosystems caused almost complete inhibition of tumor growth . | [
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PMC11066331 | We investigated the TUSC3 gene previously, and prepared several well-characterized cellular models, therefore, for this study we chose the TUSC3-silenced SKOV3 ovarian cancer cell line. | [
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PMC11574271 | E The invasion ability was evaluated by trans-well assay. ( | [
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PMC11629192 | The sample size was small without relapsed anti-NMDAR encephalitis patients, and the follow-up time was not long enough. | [
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PMC9918897 | Mice were procured, fed, followed-up on, and euthanized under appropriate and standard conditions. | [
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PMC11738017 | The supplier information for reagents and antibodies used in this study are listed in supplemental Table 2. | [
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PMC11777207 | These findings are consistent with the idea that the PD-L1 extracellular interactions with CD80 are important for the regulation of DC migration necessary following DC activation. | [
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... |
PMC9429973 | Gene set enrichment analysis (GSEA) showed deep transcriptome rearrangements in KMH2 and HDMYZ cell lines upon arg deprivation, involving upregulation of genes required for the unfolded protein response p53 pathway and networks and proteosome degradation, with a minimal effect on metabolism features, except the upregul... | [
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PMC9817179 | We define the moment that PFA is added as time zero () and introduce two fixed states of POI, which are (POI cross-linked to proteins within puncta) with a fixation rate of and (POI cross-linked to proteins outside puncta) with a fixation rate of . | [
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PMC11711871 | After 24 h, the cells were harvested, and the extracts were prepared and assayed for firefly and Renilla luciferase activities via a dual luciferase reporter assay kit (Promega). | [
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PMC11762280 | E Representative images of MPO, MMP9, F4/80, CD4, and CD8 immunohistochemical staining in control mice and 430 mJ/cm UVB-irradiated mice at 72 h. The statistic of average optical densities of MPO, MMP9, F4/80, CD4, and CD8 positive staining were analyzed (n = 4). | [
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PMC5673955 | RrA showed a dose‐dependent cytotoxic effect for both Jurkat and CD4 cells (Fig. 1). | [
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PMC11519583 | g Fluorescence intensity of SPiDER-βGal in MPs treated with the indicated siRNAs was monitored by flow cytometric analysis (n = 3). | [
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PMC11679892 | TOS levels increased in neuroblastoma cells treated with P. sidoides extract (p < 0.01). | [
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PMC6114978 | 5-azacytidine (AZA) at 5 μM did not cause an increase in expression of MST1. | [
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PMC11486946 | We next evaluated the effects of the hit compounds on EGFR-dependent cellular viability by utilizing various cell types that express EGFR because they are expected to depend on EGFR signaling for their survival: A431 and HeLa cells, which express endogenous EGFR, and EGFR-transfected Ba/F3 cells. | [
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PMC9429973 | We reported 3 cases of acute renal failure due to hemolysis as a consequence of acute tubular necrosis after procedure. | [
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... |
PMC9429973 | The study of IT in children is difficult due to the heterogeneity of the patients and the rarity of each disease. | [
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PMC9429973 | In the DREAMM-2 study, belamaf showed deep responses with a manageable safety profile in patients with relapsed/refractory multiple myeloma (RRMM). | [
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PMC2944824 | To determine if the early stages of the ER stress response was affected by Hr expression, levels of the protein chaperone GRP78 and the transcription factor CHOP were examined in COS cells treated with tunicamycin. | [
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PMC9429973 | Arms B and C are planned; patients will receive treatment until disease progression or unacceptable toxicity. | [
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PMC9429973 | Image: Summary/Conclusion: Despite short follow-up, this is the largest report on brexu-cel use in the real-world setting. | [
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PMC10748106 | Briefly, cells were cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum, and seeded in a 96-well microtiter plate at a cellular density of 5000 cells/mL, and placed in an incubator (5% CO2 and 37 °C) for 5 h. Afterward, different concentrations of pure iridoids (0.04128, 0.2064, 1.032, 5.16, 25.8, and... | [
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... |
PMC11806818 | Zhang et al. proposed a sensitive and selective colorimetric/photothermal dual-mode method for the detection of MCF-7 cell exosomes by using TMB-loaded graphene quantum dot nanodopes (TMB-GQDzymes) encapsulated in DNA nanoflowers (DFs) as probes combined with the rolling circle amplification (RCA) self-assembly effect. | [
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... |
PMC11222184 | Administration of XL-888 in SH-SY5Y cells resulted in a decrease in CASP9 expression while increasing APAF1 and CASP2 gene expression. | [
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... |
PMC11684821 | Expression of MR1*01 as a single chain (sc) β2M-MR1 protein in the MR1-KO cancer cells restored killing by MC.27.759S (Figure 2A). | [
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... |
PMC11407042 | CRITICAL: Complete digestion of cell-cell adhesion is critical. | [
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PMC10243817 | We therefore retained our interest in epithelial cell TGF-βR3. | [
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PMC7338939 | However, the changes were not significant (P > 0.05). | [
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PMC9388315 | Cinnamomum cassia confirmed by an herbalist was used. | [
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PMC11442172 | Finally, the development of the more complex CoC models requires interdisciplinary knowledge, ranging from biology to microfluidic chip engineering. | [
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PMC11357960 | The majority of patients with lung cancer exhibit drug resistance after anti-PD-1 immunotherapy, leading to shortened patient survival time. | [
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... |
PMC11317131 | A key feature of IntePACE is the tethering of the generation of phage progeny to successful recombination of att sites. | [
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... |
PMC11626627 | Protein expression of TWIST1 was detected using Western blotting in 786-O cells transfected with miR-204–3p inhibitor compared to NC and miR-204–3p mimic compared to NC. | [
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PMC11748335 | The supernatant was combined with 4uL of 5 M NaCl and incubated at 65 °C for 14–16 h. 1uL of RNase (Thermos Scientific, #EN0531) was added to samples and incubated at 37 °C for 30 min, followed by 4uL 0.5 M EDTA pH 8.0 with 8uL of 1 M Tris pH 7.0, and 1uL of Proteinase K (10 mg/mL) (Invitrogen, #100005393) at 45 °C for... | [
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... |
PMC10253973 | An excited compound activates oxygen or biomolecules and generates O2, which contributes to the death of cancer cells. | [
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PMC10728200 | Compared to the DMSO group, tumor growth was inhibited in both the IM and RSL3 groups, with the most significant inhibition observed in the IM combined with RSL3 group (Fig. 6C and S7). | [
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PMC11659734 | Since aneugenicity is a thresholded mechanism, identifying such an effect has a significant impact on risk assessment of the selected compounds. | [
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PMC11594074 | In accordance with this, studies have found that agents increasing ß-actin prevalence can be considered useful anticancer agents Furthermore, a larger population of cells in the G0/G1 cell cycle phase were arrested upon treatment, as opposed to in untreated control cells. | [
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PMC3931643 | In this study we have identified a human DLBCL line whose resistance to asTORi can be attributed in part to a low ratio of 4EBP/eIF4E expression. | [
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... |
PMC4443654 | Acc., | [
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"O",
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}
] |
PMC10502403 | PTA-treated NGMCs functioned as antigen-presenting cells, and the possibility of mutual cytotoxicity could not be ruled out (Figure S4C). | [
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"tokens": [
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... |
PMC7039683 | Tracks: SNPs: OFC-risk-associated SNPs. | [
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PMC11768927 | Moreover, Surendran et al. demonstrated that adipocytes in the TME can contribute to the tumor’s resistance to VSV and that blocking fatty acid uptake by cancer cells resensitized the tumor to VSV. | [
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PMC8316344 | Also, whether such function is via E3 remains unclear. | [
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... |
PMC11394112 | BL signals in U2932-Luc cells were observed from the second-week post-injection in both NSG-IL6 and NSG-IL6/SGM3 mice (Figure 1A,B). | [
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PMC10812665 | This change may contribute to cell pathology. | [
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PMC11643361 | Ruthenium complexes demonstrate selective toxicity by disrupting mitochondrial calcium homeostasis, a unique mechanism that may afford specificity to cancer cells. | [
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PMC11371747 | Previously we also demonstrated that a high expression of FPGS is important for the modulation of 5FU by LV (Van Triest et al., 1999). | [
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... |
PMC11484188 | However, no miRNA is currently considered a definitive diagnostic or prognostic marker for MM in clinical practice, nor has any been used in clinical trials for patients with MM. | [
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PMC11786767 | COS-7 cells were transfected with Ki67-miR or Ctrl-miR plasmids and then stained with biotin-DHPE, Ki-67 antibody, and DAPI for TT-ExM. An LSM980 microscope with an AiryScan2 detector was used to acquire images of the cells in prometaphase. | [
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"O",
"O",
... |
PMC9429973 | These patients had MPN (n=1), AML (n=1), AML in remission (n=1) and CMML (n=1), respectively. | [
{
"tags": [
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"O",
"O"
... |
PMC9429973 | The majority of patients treated with Ven-Obi still have not required a second line of CLL therapy. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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PMC11206502 | However, the same authors did not report DRAM1’s role in starvation and mTOR-mediated autophagy . | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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PMC9221284 | The soluble protein fraction was recovered after centrifugation at 13,000 rpm at 4 °C for 15 min. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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],
"tokens": [
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PMC11507371 | Intriguingly, A431 cells show significantly divergent IKKβ expression relative to their non-malignant counterparts post CAP treatment, implying the absence of Keap1-mediated IKKβ suppression. | [
{
"tags": [
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],... |
PMC10808409 | To our knowledge this is the first report to evaluate the beneficial effect of TPGS mixed micelles formula in Caco-2 human colorectal cancer cell line. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O"
],... |
PMC11783017 | Xiaojun Ma: Writing – review & editing, Supervision, Resources, Project administration, Funding acquisition, Conceptualization. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
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"O",
"O",
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"tokens": [
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"... |
PMC6803987 | Fifty ducks (serum viral load 10–10 copies/L) infected with DHBV were randomly divided into five groups by FQ-PCR: high-, middle- and low-dose groups of esculetin (80, 40, 20 mg/kg), 3TC group (20 mg/kg) and model control group (saline). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
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"O",
"O",
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"O",
"O",
... |
PMC9429973 | Nevertheless, the prognostic value of D5PS in the interim evaluation in FL (PETINT) is not well stablished. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
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],
"tokens": [
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",",
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... |
PMC10907726 | The expression of autophagy substrate p62 was notably reduced in DATS group compared to NC group, suggesting that DATS could induce autophagy in OS cells. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O"
... |
PMC11095939 | Real-time PCR to measure mRNA levels of Mecp2. ( | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
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"PCR",
"to",
"measure",
"mRNA",
"levels",
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".",
"("
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}
] |
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