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PMC11489351
In addition to the transcriptional regulation of LDHA, we also found a novel role for pHi in regulating the expression of pyruvate dehydrogenase kinase 1 (PDK1), which phosphorylates the E1 subunit of PDH to negatively regulate activity and reduce the conversion of pyruvate to AcCoA. PDK1 expression is upregulated at high pHi and downregulated at low pHi compared to control MCF10A (Fig. 5B, Table S3).
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PMC11449273
Beta-actin was used as loading control. (
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PMC11680562
The effective dispersion of all gel constituents is apparent, as shown by the lack of polymer agglomerations.
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PMC8358006
The purified ChIP DNA samples and their input DNA were diluted for library construction using Ultra II DNA Library Prep Kit (#E7645, NEB).
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PMC11740207
Recent research has demonstrated methods for differentiating human SCs into PGLCs, which mimic the behavior of PGCs during embryogenesis, particularly when cultured with specific signals such as bone morphogenetic protein 4 (BMP4) and Nodal protein (NODAL) (Shamblott et al., 1998).
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PMC11754291
This assay evaluated primary human keratinocyte viability in a 12-well plate format, with distinct plates for both sham and treated groups across different light exposures.
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PMC11354225
In our results, EGCG reduces available iron through its chelating action, which correlates with the generation of ROS mentioned earlier and influences the PPIX formation pathway.
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PMC11655498
The functions of Zta and Rta can be targeted through interactions with specific factors, whether or not post-translational modifications (PTMs) are involved.
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PMC9512971
The proportions of patients negative for SARS-CoV-2 and the distribution of disease severity were compared between the two groups using the Mantel–Haenszel test stratified by the randomization factors.
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PMC11469524
S2 Table) and a missing link in ERK-> p90RSK in HBL-1 cells.
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PMC11732523
The World Health Organization (WHO) has emphasized the importance of sustained surveillance and response efforts as the virus continued to evolve.
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PMC11271278
E Circos plot: layer 1=chromosome, 2 = CNV, 3=enhancers (gray) and super-enhancers (black), 4 = HAPI TSS, 5=ecDNA segments, center=E-P loops (black) and WGS-predicted translocations (red) in COLO320DM cells.
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PMC11777207
Experimental KikGR scheme for (B) to (P). (
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PMC9429973
Based on these findings, we tested the effect of JAK2 inhibition on cell growth of EPOR/JAK2-amplified AEL cells in in vitro culture and xenograft model.
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PMC9429973
2 patients had a refractory disease (12,5%).
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PMC10698968
Recently, some research groups generated 3D models, using the above-mentioned cell lines grown in ultra-low attachment plates or seeded on collagen scaffolds [19, 21, 23–25].
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PMC11185260
After confirming the tumor in the cerebellum by MRI, treatment was initiated and tumor growth was monitored (Figure 7A).
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PMC11711345
Fourier transform infrared spectrophotometry (FTIR, 4000-400 cm-1) was conducted at 1%w/w in spectroscopic grade KBr in an IRAffinity–1S spectrometer (Shimadzu) at room temperature.
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PMC9429973
57% of patients were female and 43% male and the age of SVT onset was 49 years or less in 70% of patients.
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PMC11281366
Control lentiviruses were also produced using the lentiCRISPR v2 without the single guide RNA (sgRNA).
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PMC11727062
Monomers derived from hot herbs, including Zingiberis Rhizoma, Evodia Rutaecarpa, and Deer Blood, are resistant to the development of melanoma (Figure 5).
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PMC10719213
These results are in line with previous data indicating that 10 nM cladribine would be too high, because of significant cytotoxicity already after 2 days in cultured ex vivo human lymphocytes We obtained blood samples from eight patients with relapsing MS and four controls.
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PMC11703992
DDIT4 and ARHGAP15 were identified as critical genes.
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PMC11764090
The AtCRLK1–AtMEKK1/2–AtMPK4/6 cascade enhances cold tolerance by counteracting the AtMPK3/6 pathway .
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PMC11509309
The statistical significance of differences between experimental groups was calculated by one-way analysis of variance test followed by Dunnett’s post hoc test.
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PMC11549612
BOLA2 has been closely associated with hepatocellular carcinoma tumor growth and progression.
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PMC10667689
Furthermore, there are two more recent studies on T cells and macrophages revealing that TIM-3 has a direct role in controlling glucose metabolism.
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PMC11655498
KLF4 and BLIMP1 are two differentiation-dependent transcription factors that synergistically induce EBV lytic replication.
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PMC11701801
We show that treatment with CBP/p300 dual inhibitors causes synthetic lethality in cBAF-deficient cancers such as SMARCA4/SMARCA2-deficient and SS18–SSX fusion cancers.
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PMC11138140
Cardiomyocyte hypertrophy—an increase in the size of individual heart muscle cells—is a hallmark feature of many cardiovascular diseases that may arise from a number of pathological conditions including hypertension, myocardial infarction, and valve dysfunction.
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PMC11063646
4In-vitro drug release pattern from optimized nanoemulgel ANG 12.Table 8Release kinetics of andrographolide from optimized nanoemulgel ANG 12.In-vitro Drug release kinetics of ANG 12Kinetic equationR valuesZero orderY = 3.5252x + 13.719R = 0.95521st order kineticsY = 0.0465x − 2.067R = 0.9326HiguchiY = 0.0507-x0.272R = 0.9918Korsmeyer-PeppasY = 1.455x + 0.256R = 0.7945Hixson-CrowellY = 0.1077x + 0.085R = 0.9818 In-vitro drug release pattern from optimized nanoemulgel ANG 12.
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PMC11473843
Whereas introduction of FAK, FAK, FAK, FAK and FAK allowed a similar proliferation of HBEC3-FAK KO cells in presence or absence of mutKRAS, FAK and FAK evidenced impaired proliferation only in the presence of mutKRAS (Figs. 1G,H and EV1G–J).
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PMC11546117
Stock solutions were stored at −20 °C for a maximum of 6 months.
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PMC10850553
At 1 h after the administration of the Thy-1.1 antibody, animals were sacrificed as described above, and the bilateral kidneys were harvested.
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PMC9429973
Hence, most studies of NPM1c have focused on a potential cytoplasmic role.
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PMC11350568
To further validate the unique multifunctionality of the AptG-1-TfR1 TMPDS, we expanded our study to A549 cells (lung cancer cell line, moderate expression levels of PTK7 and CD71, as shown in Figure 5a,b), MDA-MB-231 (triple-negative breast cancer cell line, moderate expression levels of PTK7 and CD71, as shown in Figure S5a), and MV-4–11 (acute myeloid leukemia cell line, lowest expression levels of PTK7 and CD71, Figure 5a,b).
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PMC9429973
All analyses were performed using R version 4.1.1.
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PMC9545474
To test if NAC would have the same effect on the anticancer activity of complexes 6 and 8, A2780 and A2780cisR cells were co‐incubated with a large excess of NAC (5 mM) for 30 minutes before the treatment of cells with the complexes at IC50 concentrations.
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PMC11547972
Once metastasized, RCC is difficult to treat.
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PMC9429973
In addition, their genetics are significantly different from non-IgD MM: IgD MM patients have more complex karyotypes, amplification of 1q21 and t (11;14), while less deletion of 13q and HRCA.
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PMC9436459
Subsequently, methylation of S16 and S17 obtained the previously reported mulberrofuran C heptamethyl ether (6a) and the permethylation product of chalcomoracin (5), chalcomoracin heptamethyl ether (5a), respectively, which assisted to confirm the stereochemistry of the exo and endo adducts.
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PMC11730000
When the cells were harvested for the comet assay, a cell viability test was conducted.
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PMC10840195
According to the GEPIA database, patients with high Twist expression have shorter OS (C) and PFS (D) times than those with low Twist expression Twist is the key protein in the EMT and Wnt signalling pathway interaction.
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PMC11087766
This leads to degradation of both phage and host cellular RNA, cell dormancy, and phage restriction (40) (Fig. 3A).
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PMC11754436
At present, research on NPEPPS is limited and, to the best of our knowledge, there is no research report on NPEPPS in human tumors.
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PMC11674891
Elevated FNDC4 expression is linked to poor survival in hepatocellular carcinoma, where it promotes migration and invasion via the PI3K/Akt signaling pathway .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Elevated", "FNDC4", "expression", "is", "linked", "to", "poor", "survival", "in", "hepatocellular", "carcinoma", ",", "where", "it", "promotes", "migration", "and", "invasion", "via", "the", "PI3K/Akt", "signaling", "pathway", "." ] } ]
PMC11763111
In humanized mouse models, anti-CD38 universal CAR-T cells demonstrated potent antitumor efficacy.
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PMC5673955
For further calculations mean telomere length was considered actual if the intra‐experimental coefficient of variation was not higher than 2%.
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PMC11610461
To explore the molecular mechanisms of PSENEN action in KIRC, we conducted GO and KEGG analyses which uncovered that some enriched pathways were associated with inflammatory response and immune regulation, such as humoral immune response, immunoglobulin complexes, complement and coagulation cascade reactions, and neutrophil extracellular trap formation.
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PMC11640247
Tissues were collected at P0 and P7 for further analysis.
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PMC11185260
All experiments were performed in accordance with the approved GUACUC protocols of the Georgetown University.
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PMC11737091
DBF4 expression in the GSE53757 dataset (72 cancerous tissues and 72 paracancerous tissues) and (E) GSE36895 dataset (29 cancerous tissues and 23 paracancerous tissues) (F-H) Increased expression of DBF4 was detected in the subgroups of higher individual cancer stage, gender, and age. *,
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PMC11787651
To date, the most effective and accurate way to study histone modifications and epigenetic aberrations is with mass spectrometry (MS).
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PMC9429973
Twenty-seven pts died including 19 pts due to disease progression.
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PMC10808409
The absence of the endothermic peak of FA in the DSC thermogram of TPGS mixed micelles (O2) confirms that FA was encapsulated inside the micellar core and that it has been converted from the crystalline state to the amorphous state.
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PMC11795610
All the results indicated that myricetin could promote the keratinocyte differentiation induced by Ca.
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PMC9429973
Prominent among these were significant changes in signaling pathways of the TGFβ ligand family.
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PMC11499955
High rate constant values k were found in all cases: between 85 and 325 M s depending on the antibody (Fig. 3 and S6†).
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PMC7887261
STAU2 is a double-stranded RNA-binding protein and a major regulator of mRNA transport, decay, and translation.
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PMC11629192
Following the fourth OFA dose, the patient showed gradual improvement, including reduction in dyskinesias and dystonia, resolution of agitation, and the restoration of nighttime sleep and ability to engage in simple communication.
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PMC11409031
Through the application of the LOOCV framework on the TCGA-OV dataset, we tested 113 different predictive models and computed the C-index for each.
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PMC11543853
Seven to sixty minutes post-infection, enterovirus particles were both in membrane-bound vesicles and cytoplasm, indicating that enterovirus cell entry was a continuous and unsynchronized process.
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PMC9429973
She had a minimal response to IVIG only.
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PMC11380454
; ARA-C (cytosine β-D-arabinoside) (Sigma); LY294002 (Calbiochem; Dermstadtt, Germany); XTT cell proliferation kit (Biological Industries); anti-pAkt, anti-Akt, anti-pNFκB, and anti-NFκB antibodies (Cell Signaling Technology, MA, USA); anti-CD49d and anti-CD49e antibodies (Serotec, NC, USA); Alexa Fluor 488-conjugated anti-mouse IL-10 antibody (BioLegend, San Diego, CA, USA); lipofectamine (Invitrogen, Carlsbad, CA); PE-conjugated anti-CD8a monoclonal antibody (eBioscience, San Diego, CA, USA); PE-conjugated anti-human PD-L1 antibody (eBioscience); PE-conjugated anti-mouse PD-L1 antibody (Cell Signaling Technology); anti-PD-1 neutralizing antibodies (rat isotype; clone RPMI-14) and isotype control immunoglobulin (rat IgG2a) (Bioxell; Lebanon, In.
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PMC11672881
Moreover, the connection between tryptophan metabolism and apoptosis has been highlighted, suggesting that the combination treatment may induce oxidative stress and promote apoptotic processes in cancer cells .
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PMC11095939
WB of Mecp2, pRb, Cyclin D1, Cyclin E1, Cyclin A1, and Cyclin B1 in quiescent 3T3 cells upon CIL.
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PMC10123657
By analyzing results from alternate injections of samples from the OP9 and CCRF-CEM cells grown in monoculture, it was determined that contaminant peptides led to less than seven valid identifications of proteins from one species in the samples of the other, none of which were considered for further analysis or included in the Supplementary Table S1.
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PMC9429973
Aims: To evaluate the efficacy and safety of M monotherapy (mono) retreatment in pts with R/R NHL from an ongoing Phase I/II study (NCT02500407).
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PMC9368503
A permutation-based FDR threshold of 0.05 and artificial within-group variance of 0.1 were applied in Perseus to identify significant differentially regulated proteins .
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PMC11095939
We then asked whether the expression pattern of Mecp2 during the quiescence-proliferation transition is universal in cells.
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PMC10568263
The Rct-value of antiHSP70/EN-LC/Au@MnO2/MoO3/SPE was increased to 1.74 kΩ when the anti-HSP70 was immobilized on the electrode surface.
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PMC9429973
Aims: To correlate non-quantitative metabolomics data obtained from dried blood spots (DBS), one of the inputs for GenoMED4all, to quantitative measurement of 2,3-DPG.
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PMC6102174
Romero et al. reported that artemisinin (21) showed inhibition on HBsAg secretion with an IC50 value of 55 μM .
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PMC9429973
The absolute number of CAR-T cells in the PBS post infusion was higher in patients treated with axi-cel (across days 1 to 15).
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PMC9856122
Anti-HCV and PI-3 (para-influenza) activity of norsanguinarine displayed moderate action against HCV and PI-3 with minimum inhibitory concentration (MIC) range from 16 to 32 µg/mL .
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PMC10545062
The intervention boluses in response to hypotension graphed from start of bolus to 4 minutes after end of bolus sequence.
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PMC11406030
Values of p < 0.05 were considered statistically significant for all analyses.
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PMC11628309
The presence of Fe (II) makes the dopaminergic BE (2)-M17 cells more susceptible to DNA when α-synuclein is overexpressed, and this effect is even more toxic when the mutant A53T form of α-synuclein is overexpressed (Martin et al., 2003).
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PMC10218459
These preclinical in vitro data indicate that the use of CPP can enhance the efficacy of common cytostatic chemotherapeutics, and thus support the translation of CPP as an anti-tumor therapy in clinical routine.
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PMC11643361
While cobalt complexes 63–64 predominantly initiated cancer cell death through necrosis, complex 65 demonstrated the ability to induce apoptosis.
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PMC6835428
CD117, also known as c-kit, is a receptor tyrosine kinase devoted to the promotion of cell survival, metabolism, and differentiation.
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PMC8735881
TZM-bl cells expressing GPI-scFvs were used as a target and cocultured with CEMss-CCR5 donor cells that were preinfected with the HIV-1 isolates RHPA.c/2635 (D), THRO.c/2626 (E) and MJ4 (F). %
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PMC11730000
The generation of ROS due to DOX administration was quantified by analyzing DHE fluorescence, with an illustrative example provided in Figure 3A.
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PMC11281366
Infections were performed via spinoculation (centrifugation at 1200× g at 22 °C for 2 h).
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PMC11721295
Mechanistically, we show that fibroblasts are a key signaling hub, mediating interactions between epithelial cells and macrophages, and thus, potentially mediating the immunosuppressive status of tumors.
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PMC11525293
Cell extracts were prepared and analyzed by WB with anti-ACE2 and anti-p63 Abs, and parallel samples were used for ACE2 mRNA level evaluation by qRT-PCR; mRNA levels were normalized using GAPDH as housekeeping gene.
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PMC11740508
Clinical studies suggest that PARPi have toxicities often requiring dose reduction to ineffective concentrations.
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PMC11612626
Pretreatment of E.G7-Ova-GFP-Luc cells with compound A also extended mouse survival compared with that of mice injected with E.G7-Ova-GFP-Luc cells treated with vehicle alone (Supplementary Fig. S7G).
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PMC11277157
Notably, cell lines exhibit intrinsic capacity to cope with oxidative stress, with neuronal-like cells being more sensitive than other cells’ origins .
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PMC10253973
These complexes were more active in comparison to the 3D model of MCF-7 nodular cells at lower concentrations of compounds (Figure 9) .
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PMC5311252
Further, these results were confirmed for miR-372 in several NSCLC models stably expressing miR-372.
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PMC6461034
Data from the above web resources are used to annotate all rows in order to prioritize rows that link the same phosphosite to the same gene.
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PMC10994876
Additionally, it significantly contributes in augmenting viability, size, and proliferation.
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PMC7192625
On the contrary, using the distance-preserving randomizations leads to expected ChAs values that can be positive and high, so that only ChAs values outside of these random ranges can be considered significant (Supplementary Figure S1C).
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PMC11321678
We found overexpression of EOMES in Group 3/4 MB cells led to increased expression of LHX2 (Figure S8G, Supporting Information, p < 0.0001).
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PMC11632064
Densitometric analysis of three independent cytokine arrays performed in MeWo cells treated with RSK inhibitors for 72 h. (J) Modulation of transcripts associated with phenotype switching from RNA-seq analyses performed on MeWo cells treated with BI-D1870 for 72 h compared to DMSO.
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PMC11767582
for C17H17BrN3O4 [M+H]: 406.0397, found: 406.0379.
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PMC8526701
A GIST-882 cells were treated with GSK602 combined with imatinib at indicated concentration for 48 h. Cell viability was analyzed by MTT.
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PMC11699178
The results were visualized using a heatmap, with correlation coefficients ranging between -1 and 1, indicating the strength and direction of the correlation.
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PMC10882807
qRT-PCR analyzed the expression of hsa_circ_0005397 in cell lines. (*
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